Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 OR2Z1

3.67e-0843115317GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR8H2 OR8H3 OR8J3 OR2T27 PDGFRB OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 ADGRV1 OR2T11 AR OR51J1 OR4D2 OR51E2 CELSR3 OR1A1 OR1E3 OR10K2 LGR6 OR2Z1

1.08e-0688415322GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR8H2 OR8H3 OR8J3 OR2T27 PDGFRB OR4D9 OR4D1 OR1A2 OR4D11 GRIN1 OR2T12 ADGRV1 OR2T11 AR OR51J1 OR4D2 OR51E2 TGFBR3 PTK2B BMPR2 CELSR3 OR1A1 PTCH2 OR1E3 OR10K2 LGR6 OR2Z1 MERTK

1.28e-06135315328GO:0004888
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

CTU2 RNGTT ERN1 PDGFRB SPEG GNPTAB TERT POLR3A SGK3 TGFBR3 PTK2B PARP10 BMPR2 NEK5 PIK3CA DSTYK POLL PRKCQ MERTK PIGO

3.32e-0593815320GO:0016772
GeneOntologyBiologicalProcesssensory perception of smell

OR8H2 OR8H3 OR8J3 OR2T27 OBP2B OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 OR2Z1

8.44e-0946515018GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 PLCB2 OR2Z1

1.61e-0848515018GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 OR2Z1

1.77e-0843215017GO:0050911
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR8H2 OR8H3 OR8J3 OR2T27 OBP2B OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 PLCB2 OR2Z1

1.81e-0854715019GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 ADGRV1 OR2T11 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 PLCB2 OR2Z1

4.84e-0858215019GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 PLCB2 OR2Z1

5.23e-0852415018GO:0009593
GeneOntologyBiologicalProcesssensory perception

OR8H2 OR8H3 OR8J3 OR2T27 OBP2B PDE6B OR4D9 OR4D1 OR1A2 OR4D11 GRIN1 OR2T12 ADGRV1 OR2T11 OR51J1 OR4D2 RNF170 OR51E2 OR1A1 OR1E3 SLC17A8 OR10K2 PLCB2 TRPM1 OLFM2 OR2Z1

5.81e-08107215026GO:0007600
GeneOntologyBiologicalProcessdetection of stimulus

OR8H2 OR8H3 OR8J3 OR2T27 PDE6B OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 ADGRV1 OR2T11 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 PLCB2 OR2Z1

2.98e-0772215020GO:0051606
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR8H2 OR8H3 OR8J3 OR2T27 PDGFRB OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 ADGRV1 OR2T11 AR OR51J1 OR4D2 OR51E2 PTK2B CELSR3 OR1A1 OR1E3 OR10K2 RGS17 PLCB2 PLCB4 TRPM1 LGR6 OR2Z1

2.66e-06139515027GO:0007186
GeneOntologyCellularComponentpole plasm

PIWIL1 MOV10L1 HELZ TDRD6

5.40e-05291514GO:0045495
GeneOntologyCellularComponentgerm plasm

PIWIL1 MOV10L1 HELZ TDRD6

5.40e-05291514GO:0060293
GeneOntologyCellularComponentP granule

PIWIL1 MOV10L1 HELZ TDRD6

5.40e-05291514GO:0043186
GeneOntologyCellularComponentionotropic glutamate receptor complex

GRIN1 PTK2B DLG3 OLFM2

3.10e-04451514GO:0008328
GeneOntologyCellularComponentneurotransmitter receptor complex

GRIN1 PTK2B DLG3 OLFM2

4.65e-04501514GO:0098878
DomainOlfact_rcpt

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR4D2 OR51E2 OR1A1 OR10K2 OR2Z1

5.09e-0739314715IPR000725
Domain7tm_1

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR4D2 OR51E2 OR1A1 OR10K2 LGR6 OR2Z1

8.81e-0567714716PF00001
DomainG_PROTEIN_RECEP_F1_1

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR4D2 OR51E2 OR1A1 OR10K2 LGR6 OR2Z1

1.01e-0468514716PS00237
DomainG_PROTEIN_RECEP_F1_2

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR4D2 OR51E2 OR1A1 OR10K2 LGR6 OR2Z1

1.12e-0469114716PS50262
DomainGPCR_Rhodpsn

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR4D2 OR51E2 OR1A1 OR10K2 LGR6 OR2Z1

1.14e-0469214716IPR000276
DomainGPCR_Rhodpsn_7TM

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR4D2 OR51E2 OR1A1 OR10K2 OR2Z1

2.65e-0467014715IPR017452
PathwayREACTOME_SENSORY_PERCEPTION

OR8H2 OR8H3 OR8J3 OR2T27 PDE6B OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 SLC17A8 OR10K2 PLCB2 PRKCQ OR2Z1

2.81e-0863611321M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 OR2Z1

3.44e-0841711317M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR4D2 OR51E2 OR1A1 OR10K2 OR2Z1

4.83e-0738911315M14091
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR8H2 OR8H3 OR8J3 OR4D1 OR1A2 OR4D11 OR2T12 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 OR2Z1

3.93e-103401531411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR8H2 OR8H3 OR8J3 OR4D1 OR1A2 OR4D11 OR2T12 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 OR2Z1

3.93e-103401531411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR8H2 OR8H3 OR8J3 OR4D1 OR1A2 OR4D11 OR2T12 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 OR2Z1

4.41e-103431531432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR8H2 OR8H3 OR8J3 OR4D1 OR1A2 OR4D11 OR2T12 OR51J1 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 OR2Z1

4.93e-103461531414611657
Pubmed

The human olfactory receptor gene family.

OR8H2 OR8H3 OR8J3 OR2T27 OR4D9 OR4D1 OR1A2 OR4D11 OR2T12 OR2T11 OR4D2 OR51E2 OR1A1 OR1E3 OR10K2 OR2Z1

2.55e-095411531614983052
Pubmed

Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.

OR2T27 OR4D1 OR2T12 OR2T11 OR4D2 OR1A1

5.32e-0846153632126975
Pubmed

Olfactory receptors and signalling elements in the Grueneberg ganglion.

OR8H2 OR8H3 OR4D1 OR1E3

8.20e-0717153416805845
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PDGFRB GNPTAB CEP290 USP25 CHD9 TUBGCP5 ME3 FAN1 CEP350 CYRIA CELSR3 EHMT2 ZNF451 RTRAF CCDC15 MRPL38 MERTK CRTAP BRWD1

4.05e-0612851531935914814
Pubmed

Mouse-human orthology relationships in an olfactory receptor gene cluster.

OR1A2 OR1A1 OR1E3

4.60e-068153311170746
Pubmed

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.

MPP3 PDE6B PDGFRB GNPTAB CEP290 PIK3CA PRKCQ MERTK

9.66e-06233153832290105
Pubmed

Inhibition of telomerase potentiates enzalutamide efficiency of androgen-sensitive human prostate cancer cells.

TERT AR

1.92e-052153229332354
Pubmed

Phosphatidylinositol-3-kinase regulates PKCtheta activity in cytotoxic T cells.

PIK3CA PRKCQ

1.92e-052153215829307
Pubmed

Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.

PTGIS BMPR2

1.92e-052153224605778
Pubmed

Translational attenuation and retinal degeneration in mice with an active integrated stress response.

PDE6B CEP290

1.92e-052153229706649
Pubmed

piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis.

PIWIL1 TDRD6

1.92e-052153238491008
Pubmed

Identification of two new mutations in the GPR98 and the PDE6B genes segregating in a Tunisian family.

PDE6B ADGRV1

1.92e-052153218854872
Pubmed

Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.

OR1A2 OR1A1

1.92e-052153217601748
Pubmed

Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells.

OR51E2 PTK2B

1.92e-052153225219547
Pubmed

A novel nonsense mutation in CEP290 induces exon skipping and leads to a relatively mild retinal phenotype.

CEP290 MERTK

1.92e-052153220130272
Pubmed

Mutations in the telomerase reverse transcriptase promoter and PIK3CA gene are common events in penile squamous cell carcinoma of Italian and Ugandan patients.

TERT PIK3CA

1.92e-052153235253909
Pubmed

Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase.

PDGFRB TGM1

1.92e-052153219386600
Pubmed

Mutational profiling of poorly differentiated and anaplastic thyroid carcinoma by the use of targeted next-generation sequencing.

TERT PIK3CA

1.92e-052153231230400
Pubmed

Wild-type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development.

TERT AR

1.92e-052153217991730
Pubmed

High frequency of PIK3CA and TERT promoter mutations in fibromatosis-like spindle cell carcinomas.

TERT PIK3CA

1.92e-052153233952589
Pubmed

Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.

PDE6B DYSF

1.92e-052153224655396
Pubmed

Olfactory receptor 43 reduces hepatic lipid accumulation and adiposity in mice.

OR1A2 OR1A1

1.92e-052153230639733
Pubmed

A Natural Occurring Mouse Model with Adgrv1 Mutation of Usher Syndrome 2C and Characterization of its Recombinant Inbred Strains.

PDE6B ADGRV1

1.92e-052153229961073
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR8J3 OR1A2 OR1A1 OR1E3 OR2Z1

1.95e-0574153515081110
Pubmed

Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.

PDGFRB ARX GLI1 PTCH2

2.12e-0537153426697723
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

B4GALT7 PROCR GNPTAB TMEM214 GLB1L2 PLBD2 RNF170 THEM6 BMPR2 CELSR3 ALG9 UTP20 EDEM1 AKAP1 PIGO DSE CRTAP

2.35e-0512011531735696571
Pubmed

A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.

TRAPPC11 PIWIL1 NPRL3 AKAP1

2.91e-0540153420308539
Pubmed

Mouse model resources for vision research.

PDE6B CEP290 TRPM1 MERTK

3.21e-0541153421052544
Pubmed

The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing.

PIWIL1 MOV10L1 TDRD6

3.65e-0515153325762440
Pubmed

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

OR1A2 OR1A1 OR1E3

4.48e-0516153310673334
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR8J3 OR4D1 OR1A2 OR4D11 OR4D2 OR1A1 OR2Z1

5.55e-05219153712213199
Pubmed

A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability.

PDE6B AR

5.75e-053153222736030
Pubmed

Functional role of SGK3 in PI3K/Pten driven liver tumor development.

SGK3 PIK3CA

5.75e-053153230975125
Pubmed

Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1.

ABHD2 TRPM1

5.75e-053153228813576
Pubmed

The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.

PTK2B PIK3CA

5.75e-053153220308428
Pubmed

ErbB-2 via PYK2 upregulates the adhesive ability of androgen receptor-positive human prostate cancer cells.

AR PTK2B

5.75e-053153217563746
Pubmed

Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains.

AR PIK3CA

5.75e-053153217635910
Pubmed

TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice.

PIWIL1 MOV10L1

5.75e-053153229317670
Pubmed

Suppression of survival signalling pathways by the phosphatase PHLPP.

PIK3CA PHLPP1

5.75e-053153222340730
Pubmed

Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer.

AR PIK3CA

5.75e-053153226506516
Pubmed

Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator.

AR PTK2B

5.75e-053153211856738
Pubmed

An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth.

AR CYP7B1

5.75e-053153212370428
Pubmed

MIWI prevents aneuploidy during meiosis by cleaving excess satellite RNA.

PIWIL1 MOV10L1

5.75e-053153232677148
Pubmed

Loss of androgen signaling in mesenchymal sonic hedgehog responsive cells diminishes prostate development, growth, and regeneration.

AR GLI1

5.75e-053153231929563
Pubmed

Human telomerase reverse transcriptase (hTERT) synergistic with Sp1 upregulate Gli1 expression and increase gastric cancer invasion and metastasis.

TERT GLI1

5.75e-053153234601664
Pubmed

Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism.

TERT PIK3CA

5.75e-053153223624506
Pubmed

SAP102 mediates synaptic clearance of NMDA receptors.

GRIN1 DLG3

5.75e-053153223103165
Pubmed

PYK2 via S6K1 regulates the function of androgen receptors and the growth of prostate cancer cells.

AR PTK2B

5.75e-053153227492635
Pubmed

[THE SOMATIC MUTATIONS AND ABERRANT METHYLATION AS POTENTIAL GENETIC MARKERS OF URINARY BLADDER CANCER].

TERT PIK3CA

5.75e-053153227455559
Pubmed

Retrotransposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germline.

PIWIL1 MOV10L1

5.75e-053153225480952
Pubmed

GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor.

AR GLI1

5.75e-053153221172305
Pubmed

Prognostic value of androgen receptor and FOXA1 co-expression in non-metastatic triple negative breast cancer and correlation with other biomarkers.

AR PIK3CA

5.75e-053153229880907
Pubmed

Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis.

GLI1 PTCH2 PRKCQ

9.01e-0520153320637749
Pubmed

Essential roles of G9a in cell proliferation and differentiation during tooth development.

EHMT2 GLI1 PTCH2

9.01e-0520153328527696
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

PDE6B PLCB2 PLCB4

1.05e-0421153330270038
Pubmed

Silencing of ST6GalNAc I suppresses the proliferation, migration and invasion of hepatocarcinoma cells through PI3K/AKT/NF-κB pathway.

ST6GALNAC1 PIK3CA

1.15e-044153227235117
Pubmed

SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.

SGK3 PIK3CA

1.15e-044153225458846
Pubmed

Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain.

PLCB2 PLCB4

1.15e-04415329753089
Pubmed

Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina.

PDE6B PRKCQ

1.15e-044153216503160
Pubmed

Trpm1: Novel function at the intersection of light and pain response in the iris.

PDE6B TRPM1

1.15e-044153234954202
Pubmed

Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis.

AR GLI1

1.15e-044153227760825
Pubmed

Quantification of Oxygen Consumption in Retina Ex Vivo Demonstrates Limited Reserve Capacity of Photoreceptor Mitochondria.

PDE6B CEP290

1.15e-044153226747773
Pubmed

Monosodium urate activates Src/Pyk2/PI3 kinase and cathepsin dependent unconventional protein secretion from human primary macrophages.

PTK2B PIK3CA

1.15e-044153223292187
Pubmed

Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.

PDE6B TRPM1

1.15e-044153222211741
Pubmed

Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis.

PIWIL1 MOV10L1

1.15e-044153230590800
Pubmed

Binding to the platelet-derived growth factor receptor transiently activates the p85alpha-p110alpha phosphoinositide 3-kinase complex in vivo.

PDGFRB PIK3CA

1.15e-04415328702949
Pubmed

Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates.

PDGFRB PIK3CA

1.15e-044153212933652
Pubmed

Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations.

PDE6B MERTK

1.15e-044153218925574
Pubmed

Stromal androgen and hedgehog signaling regulates stem cell niches in pubertal prostate development.

AR GLI1

1.15e-044153234427305
Pubmed

Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.

PLCB2 PLCB4

1.15e-04415329305844
Pubmed

Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation.

PLCB2 PLCB4

1.15e-044153215174099
Pubmed

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.

AR EHMT2

1.15e-044153226751641
Pubmed

Prognostic value of PIK3CA mutation status, PTEN and androgen receptor expression for metastasis-free survival in HER2-positive breast cancer patients treated with trastuzumab in adjuvant setting.

AR PIK3CA

1.15e-044153226247526
Pubmed

Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, θ.

PDE6B PRKCQ

1.15e-044153226978024
Pubmed

Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.

PDE6B ADGRV1

1.15e-044153237127773
Pubmed

Phospholipase C-β1 potentiates glucose-stimulated insulin secretion.

PLCB2 PLCB4

1.15e-044153231268747
Pubmed

Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102.

PTK2B DLG3

1.15e-044153212576483
Pubmed

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.

PIWIL1 MOV10L1

1.15e-044153220534472
Pubmed

Gli1 promotes colorectal cancer metastasis in a Foxm1-dependent manner by activating EMT and PI3K-AKT signaling.

PIK3CA GLI1

1.15e-044153227863385
Pubmed

PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq.

PLCB2 PLCB4

1.15e-044153223006664
Pubmed

The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.

OR1A2 OR1A1 OR1E3

1.39e-0423153310706615
Pubmed

Cascade diversification directs generation of neuronal diversity in the hypothalamus.

ARX OTP GLI1

1.58e-0424153333887179
Pubmed

Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.

PDE6B CYP4A11 GLI1

1.58e-042415337873878
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

PLCB2 PLCB4 PRKCQ

1.58e-0424153310843712
Pubmed

A Large-scale genetic association study of esophageal adenocarcinoma risk.

PDGFRB TERT PTGIS ABCB4 TYMS EHMT2 PIK3CA RGS17

1.73e-04351153820453000
Pubmed

Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback.

GLI1 PTCH2

1.91e-045153234353359
Pubmed

Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population.

PDGFRB PTK2B

1.91e-045153238732165
Pubmed

Reduced NMDA receptor tyrosine phosphorylation in PTPalpha-deficient mouse synaptosomes is accompanied by inhibition of four src family kinases and Pyk2: an upstream role for PTPalpha in NMDA receptor regulation.

GRIN1 PTK2B

1.91e-045153216899073
Pubmed

Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis.

AR GLI1

1.91e-045153236323713
Pubmed

Platelet-derived growth factor receptor-α is essential for cardiac fibroblast survival.

PDGFRB GLI1

1.91e-045153231125253
Pubmed

Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene.

GDAP1 MRPS33

1.91e-045153210217254
Pubmed

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.

ABCB4 CYP7B1

1.91e-045153228604703
Pubmed

cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus.

MPP3 DLG3

1.91e-04515329838122
Pubmed

Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD-95.

GRIN1 DLG3

1.91e-045153215255944
Pubmed

Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.

CELSR3 GLI1 PTCH2

2.01e-0426153337228654
Pubmed

Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.

PLCB2 PLCB4 PRKCQ

2.26e-0427153320336759
Cytoband11q12.1

OR8H2 OR8H3 OR8J3 OR4D9 OR4D11

2.15e-04161153511q12.1
CytobandEnsembl 112 genes in cytogenetic band chr17q22

OR4D1 CA10 OR4D2 AKAP1

2.22e-04881534chr17q22
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MPP3 ERN1 ESRP1 ADGRV1 PRKCQ AKAP1 ACSL5

3.60e-061861527e83718fabb057100835d3357df407f283d23fe16
ToppCell343B-Lymphocytic-ILC-ILC-1|343B / Donor, Lineage, Cell class and subclass (all cells)

KLHL6 CTU2 PGGHG VPS50 NADSYN1 DSTYK PRKCQ

3.86e-0618815278f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MPP3 ERN1 ESRP1 ADGRV1 RGS17 PRKCQ AKAP1

3.86e-0618815274bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KLHL6 ERN1 TERT TMC3 PTK2B CYRIA MERTK

5.25e-061971527749e0e332644543cbdf2ee38c2b301ce0a019a7f
DrugPivampicillin [33817-20-8]; Down 200; 8.6uM; MCF7; HT_HG-U133A

MPP3 ABHD2 CEP290 GLB1L2 HMG20B VPS13D SSH3 DSTYK DLG3 EDEM1

7.78e-07196151105465_DN
Diseaseretinal degeneration (implicated_via_orthology)

PDE6B CEP290 PLCB4 MERTK

1.99e-05331444DOID:8466 (implicated_via_orthology)
Diseaseviral hepatitis (is_marker_for)

TERT STAT4

7.07e-0531442DOID:1884 (is_marker_for)
DiseaseMalignant neoplasm of breast

CTU2 DYSF TERT AR STAT4 SGK3 TYMS BMPR2 PIK3CA GLI1 UTP20 FGD5 LGR6 FASTKD3 DOP1A

2.54e-04107414415C0006142
DiseasePigmented Basal Cell Carcinoma

TERT PIK3CA PTCH2

3.41e-04281443C1368275
DiseaseHyperphosphatasia-intellectual disability syndrome

PGAP3 PIGO

3.50e-0461442cv:C1855923
Diseaseprimary ciliary dyskinesia (is_implicated_in)

DNAH7 BRWD1

3.50e-0461442DOID:9562 (is_implicated_in)
DiseaseCarcinoma, Basal Cell

TERT PIK3CA PTCH2

3.79e-04291443C4721806
DiseaseCHARGE syndrome (implicated_via_orthology)

CHD9 SEMA3E

4.89e-0471442DOID:0050834 (implicated_via_orthology)
DiseaseHyperphosphatasia with Mental Retardation

PGAP3 PIGO

4.89e-0471442C1855923
Diseasemean reticulocyte volume

RTTN TERT ME3 ABCB4 CEP350 TYMS CYRIA PIK3CA ALG9 NPRL3 PIGO MYO16

5.70e-0479914412EFO_0010701
DiseaseUnilateral agenesis of kidney

GREB1L DSTYK

6.50e-0481442C0266294
Diseasecystic fibrosis (implicated_via_orthology)

ABCB4 EDEM1

8.33e-0491442DOID:1485 (implicated_via_orthology)
Diseaseidiopathic pulmonary fibrosis (is_implicated_in)

TERT EHMT2

8.33e-0491442DOID:0050156 (is_implicated_in)
Diseasenon-syndromic X-linked intellectual disability (implicated_via_orthology)

ARX DLG3

8.33e-0491442DOID:0050776 (implicated_via_orthology)
DiseaseLiver carcinoma

CYP4A11 TERT AR STAT4 ABCB4 TYMS CELSR3 PIK3CA GLI1

8.93e-045071449C2239176
Diseaseprimary biliary cholangitis (is_implicated_in)

STAT4 ABCB4

1.04e-03101442DOID:12236 (is_implicated_in)
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

CYP4A11 PIK3CA

1.26e-03111442DOID:0110861 (biomarker_via_orthology)
DiseaseGastric Adenocarcinoma

ERN1 PDGFRB SPEG

1.39e-03451443C0278701
DiseaseNight blindness, congenital stationary, type 1

PDE6B TRPM1

1.51e-03121442C3501847
DiseaseNight Blindness, Congenital Stationary, Type 1A

PDE6B TRPM1

1.51e-03121442C3495587
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)

PDE6B TRPM1

1.51e-03121442C1864877
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B

PDE6B TRPM1

1.51e-03121442C1850362
DiseaseX-Linked Csnb

PDE6B TRPM1

1.51e-03121442C3711543
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A

PDE6B TRPM1

1.51e-03121442C1848172
Diseasedisks large homolog 3 measurement

MPP3 DLG3

1.51e-03121442EFO_0802472
Diseasesevere acute respiratory syndrome, COVID-19

MXRA5 GDAP1 CCDC148 ZFYVE28 TGFBR3 RGS17 TRPM1 OR2Z1

1.63e-034471448EFO_0000694, MONDO_0100096
Diseaseantibody measurement

C12orf56 ZFYVE28 NEK5

1.78e-03491443EFO_0004556
DiseaseCone-rod synaptic disorder, congenital nonprogressive

PDE6B TRPM1

1.78e-03131442C4041558
Diseasetyrosine-protein kinase receptor Tie-1, soluble measurement

OBP2B NPRL3

1.78e-03131442EFO_0008312
Diseasehepatocellular carcinoma (is_implicated_in)

ERN1 TERT STAT4 TYMS PIK3CA

1.99e-031811445DOID:684 (is_implicated_in)
Diseaseinflammatory biomarker measurement, YKL40 measurement

ZFYVE28 PHLPP1 MYO16

2.00e-03511443EFO_0004869, EFO_0004872
DiseaseAutosomal recessive limb-girdle muscular dystrophy

TRAPPC11 DYSF

2.07e-03141442cv:C2931907
Disease5-methyluridine (ribothymidine) measurement

CPT1B SEMA3E

2.07e-03141442EFO_0020013
Diseasesystemic lupus erythematosus, COVID-19

OBP2B STAT4 MICB

2.89e-03581443MONDO_0007915, MONDO_0100096
DiseaseNight blindness, congenital stationary

PDE6B TRPM1

3.07e-03171442C0339535
Diseasealpha-L-iduronidase measurement

PDE6B GNPTAB

3.07e-03171442EFO_0020139
Diseaseandrostenedione measurement, estrone measurement

OR4D1 OR4D2

3.44e-03181442EFO_0007970, EFO_0007972
DiseaseAPOE carrier status, dementia

OR4D1 OR4D2 NADSYN1

3.49e-03621443EFO_0007659, MONDO_0001627
DiseaseDisorder of eye

PDE6B CEP290 ADGRV1 TRPM1 MERTK

3.92e-032121445C0015397
Diseasevenous thromboembolism, fibrinogen measurement

PROCR CHD9 PARP10

4.34e-03671443EFO_0004286, EFO_0004623
DiseaseMammary Carcinoma, Human

CTU2 TERT AR TYMS BMPR2 PIK3CA FGD5 LGR6

4.36e-035251448C4704874
DiseaseMammary Neoplasms, Human

CTU2 TERT AR TYMS BMPR2 PIK3CA FGD5 LGR6

4.36e-035251448C1257931
DiseaseMammary Neoplasms

CTU2 TERT AR TYMS BMPR2 PIK3CA FGD5 LGR6

4.46e-035271448C1458155

Protein segments in the cluster

PeptideGeneStartEntry
QRLHMLQISYFRDPY

PROCR

26

Q9UNN8
YSMHFDPEAIRDLIL

BRINP3

671

Q76B58
PTFHALRSLDQQMYL

AKAP1

731

Q92667
RRTLYLDMLQRYFPH

CCDC148

281

Q8NFR7
LDMLQRYFPHKSRHD

CCDC148

286

Q8NFR7
HRIYVPLMLVNAADD

ABHD2

331

P08910
PLTSLMEYLLQRFHV

ALG9

326

Q9H6U8
MHRAFKRANDPVNYL

GVINP1

2046

Q7Z2Y8
MNDEHTERRYLLFFL

ADGRV1

6001

Q8WXG9
QHRRMLTPAFHYDIL

CYP4A11

141

Q02928
FLFFRVLLLRMSPQH

DOP1A

2221

Q5JWR5
MLHQDLRFPRIAFFS

EHMT2

1126

Q96KQ7
LARLLYHTYPLRMTN

ANKRD61

331

A6NGH8
RRMPSLSTFYLLDHN

CBY3

96

A6NI87
GLKHYSDFLERMPRE

POLL

376

Q9UGP5
NIILAMISEPYNHRF

ESRP1

186

Q6NXG1
HISMLDYNPRERALY

OLFM2

416

O95897
LQIYTLMHRDSFPRF

RGS17

176

Q9UGC6
EDMSELFRPFHTLLR

ZFYVE28

251

Q9HCC9
HTPMYFLLRNLAILD

OR4D11

56

Q8NGI4
RLDLQLHTPMYFFLT

OR8H2

51

Q8N162
HFTLRFDELKMRNPA

CYRIA

136

Q9H0Q0
HTPMYFLLRNLAVLD

OR4D2

56

P58180
ADIRLHNPMYFLLAN

OR1A2

51

Q9Y585
HRLHRPMYFLLSQLS

OR2T12

51

Q8NG77
ELFHSIRMDNPFYPR

PRKCQ

586

Q04759
EVFPLLQEARMYHLS

KLHL6

286

Q8WZ60
NYRSHEALLMLPSRL

MOV10L1

971

Q9BXT6
EALLMLPSRLFYHRE

MOV10L1

976

Q9BXT6
HVSNLEFPFRKDLRM

RNGTT

321

O60942
EFPFRKDLRMHLSNT

RNGTT

326

O60942
QFELPREYRNRFLHM

GNPTAB

1181

Q3T906
MEYLSNRNFLHRDLA

MERTK

711

Q12866
MTLALNRISHIPDYA

LGR6

191

Q9HBX8
NDRLRSEMNAPYHKE

MYO16

1211

Q9Y6X6
LLMDFLNEFYAHPRL

KCNT1

366

Q5JUK3
EELLVFVPHMRRFLS

B4GALT7

106

Q9UBV7
QFMYRHSRPVFDLLD

EFCAB9

101

A8MZ26
HPRYRAENIMFLELD

KIF3C

701

O14782
AHIYATRLIQMRPFL

POLD2

51

P49005
SMFGDRRELILHYFL

EFHC2

241

Q5JST6
FIVRTERSLHAPMYL

OR51E2

46

Q9H255
LFLIRVDSRLHTPMY

OR2Z1

46

Q8NG97
VIRTDIALHQPMYLF

OR51J1

51

Q9H342
FSRFHEEILPMFDRL

PDE6B

786

P35913
YYAQLDMLRRRAHKP

NEK5

361

Q6P3R8
YDLRDMPANHQTFLR

FAM214A

976

Q32MH5
RHLFLMNDVLLYTYP

FGD5

1131

Q6ZNL6
VQHYRELLDSLPMDA

GDAP1

121

Q8TB36
NPEDLRMFARLLHYF

NPRL3

506

Q12980
MHLRSPITRAAYLFI

DSE

651

Q9UL01
LMPAQHYLLRARYAS

GLI1

581

P08151
VHDPLLAINFARMYL

TUBGCP5

641

Q96RT8
LPLHMLNNILYRFSD

FBXO25

231

Q8TCJ0
AAAEPHSLRYNLMVL

MICB

21

Q29980
APDLVFNEYRMHKSR

AR

766

P10275
LMFHPEAARAILEYR

PGGHG

311

Q32M88
IDSRLHTPMYFLLSQ

OR2T27

51

Q8NH04
HTPMYFLLSQLSLRD

OR2T27

56

Q8NH04
VDSRLQNPMYFFLRH

OR8J3

51

Q8NGG0
TLSEMRHYQRLPDYV

GREB1L

541

Q9C091
RMLYRVALLYDAHRP

HELZ

291

P42694
FLYAAQPELLRFRMT

NBAS

821

A2RRP1
LEFHYMRSLPKHERL

DSTYK

696

Q6XUX3
VDLRDLNSPHSRAMY

PIK3CA

151

P42336
RLDLQLHTPMYFFLT

OR8H3

51

Q8N146
HLFMLFERQPLIDSY

ABCB4

1006

P21439
HTPMYFLLRNLSILD

OR4D9

56

Q8NGE8
RKLMYLQELPRRDHY

OBP2B

96

Q9NPH6
RTDYHILRDPELSFM

CHD9

1981

Q3L8U1
RFPHLLAHTYRAMEL

ERN1

936

O75460
LENDILYMRAHQALP

CEP290

1996

O15078
FPRDELMPLESAYRH

CRTAP

36

O75718
RLLGDMRFLQSLHEY

DNAH7

2741

Q8WXX0
IYRVPLMEHDNIARF

BMPR2

246

Q13873
FQNMSRELYRDLALH

CEP350

361

Q5VT06
AISYLPLAHMFERIV

ACSL5

301

Q9ULC5
RYSPIPRHMLAEEDF

DLG3

366

Q92796
DQMFFHTDYRPLIRD

BRWD1

556

Q9NSI6
LYMAHDLAVRLLPAF

EDEM1

261

Q92611
YVLLHLFNRMRPHED

MARCHF11

371

A6NNE9
LARFKPMQRHLFLYE

MCF2

716

P10911
LRDMASFHERPIIFA

ME3

426

Q16798
HYPDVFTREELAMRL

ARX

351

Q96QS3
YYLLRHPEAMAAVRD

CYP7B1

306

O75881
VDLYFDHLMSRVVPL

GLB1L2

171

Q8IW92
LELRRFFKDMPHNAL

PTK2B

181

Q14289
DNRPEFTMKEYHLRL

CELSR3

751

Q9NYQ7
ELLLVHRFAPYEMLL

B3GNT6

351

Q6ZMB0
PMTYSHRLEEIRLHF

CA10

121

Q9NS85
ELYNHPDVRAFLQMD

SGK3

106

Q96BR1
MLRVFILYAENVHTP

DYSF

1

O75923
PMRDHTLKEVAFYNR

CTU2

306

Q2VPK5
LSLYELHRTPQEAIM

RING1

16

Q06587
IRLLSSRHPMLYSFQ

CPT1B

156

Q92523
HTPMYFLLRNLALID

OR4D1

56

Q15615
VTDFLLDMPYHIRSI

PDGFRB

261

P09619
VTHMLNPFIYSLRNR

OR1E3

281

Q8WZA6
IQVDSRLHTPMYFLL

OR2T11

46

Q8NH01
EPGAMRFLQLYHEDL

PARP10

451

Q53GL7
THYPDIFMREELALR

OTP

126

Q5XKR4
LNHFRSRQPIYMSLA

PGAP3

46

Q96FM1
MRALFHYNPREDRAI

MPP3

231

Q13368
SDVRLHNPMYFLLAN

OR1A1

51

Q9P1Q5
LDRALHIPMYFFLAI

OR10K2

51

Q6IF99
DFYMARLHGAIERDP

HMG20B

281

Q9P0W2
QYHIDYNPLMEARRL

PIWIL1

131

Q96J94
VPRYDLNRHLDEMCA

FAN1

51

Q9Y2M0
LMQTLRFLGLYRDEH

MRPS33

61

Q9Y291
RAHLFLLLMVRVNPY

RTL1

406

A6NKG5
MFRRKLTALDYHNPA

RTRAF

1

Q9Y224
MYLRNRLNFHRDPGF

RTTN

261

Q86VV8
VVQLARDLQMDFYPH

UTP20

111

O75691
AFDLIAALEMYHPRT

TMC3

376

Q7Z5M5
AALEMYHPRTTLRFQ

TMC3

381

Q7Z5M5
PALRSIRLKMNAFYD

TDRD6

476

O60522
LDRLELYQEMDHPLA

PLCB4

306

Q15147
PSDLDLLLHMNNARY

THEM6

56

Q8WUY1
IFLMERIFDVQLPHY

PTGIS

101

Q16647
YRLSDFQMHRALAAL

FASTKD3

11

Q14CZ7
LLMSPRQLYEHFRGD

PTCH2

321

Q9Y6C5
QMFSLAHRPVRLAEF

MICU2

336

Q8IYU8
AADAMSRLARLAPVY

POLR3A

676

O14802
DLPTLLRHAFREMFS

RNF170

176

Q96K19
QEAFREALHMDRYLL

ST6GALNAC1

476

Q9NSC7
EALHMDRYLLLHPDF

ST6GALNAC1

481

Q9NSC7
DAQEILHSRFPMPRY

SEC23A

691

Q15436
ISRDDYPAVLMHLNA

SLC6A18

341

Q96N87
THILNMAREIDNFYP

SSH3

356

Q8TE77
AEQRILRMNFHEDPY

CCDC15

816

Q0P6D6
EFRYFIHMPALQKRL

C12orf56

586

Q8IXR9
DMNALLDRFHNYILP

TMEM240

26

Q5SV17
NYHRTRLDELRMFLE

VPS50

451

Q96JG6
LPDLDYLRTMTHIVF

ZNF451

876

Q9Y4E5
HLERVYADIPFLLMT

TRAPPC11

901

Q7Z392
SVTYIFHQLLDMREP

MRPL38

326

Q96DV4
RIMSLHEAYITPRYL

SPEG

3021

Q15772
ERRAQPPSYMHIFLA

SLC25A45

91

Q8N413
SELRHMPYVDLRLKF

TMEM181

481

Q9P2C4
FYDDNFPMEIRHLLA

STAT4

21

Q14765
SPFAITYLDRLLLMH

TMEM214

291

Q6NUQ4
HRNLPFMRELRYLFA

USP25

216

Q9UHP3
MQARYSLRDEFPLLT

TYMS

61

P04818
QSGYLLKHEFMRRPD

PLCB2

651

Q00722
NMQHFLTIPRLEELY

TRPM1

486

Q7Z4N2
KFQRYQLIMTFHDRP

TRPM1

1091

Q7Z4N2
LAPAHRNLYREVMLE

ZFP69B

91

Q9UJL9
PHRYEREEAFMALNL

USP24

1816

Q9UPU5
MRLRDAPQHFYAALL

PIGO

996

Q8TEQ8
VFDRHMASTYLRPVL

PHLPP1

206

O60346
AIRFARSHPLMYQAI

SEMA3E

401

O15041
YDELIVRRGQPFHML

TGM1

136

P22735
VRLMRYNDFLHDPLS

PLBD2

476

Q8NHP8
LTDLQPYMRQFVAHL

TERT

766

O14746
SYTMAPVANRFHLRL

TGFBR3

341

Q03167
VNHLDIAPRYASILM

SLC17A8

436

Q8NDX2
EFMRPYDLQDPRIHT

VPS13D

2261

Q5THJ4
FRDYVLHMPTLRELL

L1TD1

846

Q5T7N2
RHLYLAENMVRTLPA

MXRA5

186

Q9NR99
RHTEEYFLPRMIQDL

NADSYN1

136

Q6IA69
HVVAVMLYLLDRFSP

GRIN1

571

Q05586