Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR1 ITPR2 ITPR3

1.48e-083503GO:0005220
GeneOntologyMolecularFunctionoxalate transmembrane transporter activity

SLC26A3 SLC26A2 SLC26A6

1.75e-0610503GO:0019531
GeneOntologyMolecularFunctionsecondary active sulfate transmembrane transporter activity

SLC26A3 SLC26A2 SLC26A6

2.40e-0611503GO:0008271
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR1 ITPR2 ITPR3

5.27e-0614503GO:0070679
GeneOntologyMolecularFunctionsulfate transmembrane transporter activity

SLC26A3 SLC26A2 SLC26A6

8.09e-0616503GO:0015116
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

ITPR1 ITPR2 ITPR3

1.17e-0518503GO:0015278
GeneOntologyMolecularFunctiondicarboxylic acid transmembrane transporter activity

SLC26A3 SLC26A2 SLC26A6

6.32e-0531503GO:0005310
GeneOntologyMolecularFunctionligand-gated calcium channel activity

ITPR1 ITPR2 ITPR3

6.32e-0531503GO:0099604
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

SLC26A3 SLC26A2 SLC26A6

6.96e-0532503GO:0015106
GeneOntologyMolecularFunctionsolute:inorganic anion antiporter activity

SLC26A3 SLC26A2 SLC26A6

6.96e-0532503GO:0005452
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

ITPR1 ITPR2 ITPR3

7.64e-0533503GO:0005217
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 MEF2A

4.61e-04560507GO:0001228
GeneOntologyMolecularFunctionchloride:bicarbonate antiporter activity

SLC26A3 SLC26A6

4.71e-0413502GO:0140900
GeneOntologyMolecularFunctionbicarbonate:monoatomic anion antiporter activity

SLC26A3 SLC26A6

4.71e-0413502GO:0140829
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

SLC26A3 SLC26A2 SLC26A6

4.80e-0461503GO:1901682
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 MEF2A

4.92e-04566507GO:0001216
GeneOntologyMolecularFunctionalcohol binding

ITPR1 ITPR2 ITPR3

2.13e-03102503GO:0043178
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC26A3 PIEZO2 SLC26A2 SLC26A6 ITPR1 ITPR2 ITPR3

3.42e-03793507GO:0015075
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC26A3 SLC26A2 SLC26A6

3.79e-03125503GO:0015108
GeneOntologyMolecularFunctioncalcium channel activity

ITPR1 ITPR2 ITPR3

4.14e-03129503GO:0005262
GeneOntologyMolecularFunctionantiporter activity

SLC26A3 SLC26A2 SLC26A6

4.99e-03138503GO:0015297
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

ITPR1 ITPR2 ITPR3

5.20e-03140503GO:0099094
GeneOntologyMolecularFunctionmonoatomic ion channel activity

PIEZO2 SLC26A6 ITPR1 ITPR2 ITPR3

5.69e-03459505GO:0005216
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC26A3 SLC26A2 SLC26A6

6.41e-03151503GO:0008509
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

ITPR1 ITPR2 ITPR3

6.41e-03151503GO:0015085
GeneOntologyMolecularFunctiontransporter inhibitor activity

HAMP ITPR1

7.24e-0351502GO:0141110
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF33 PRAMEF10

8.38e-0355502GO:0042974
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC26A3 SLC26A2 SLC26A6

9.01e-03171503GO:0015103
GeneOntologyMolecularFunctiongated channel activity

PIEZO2 ITPR1 ITPR2 ITPR3

9.67e-03334504GO:0022836
GeneOntologyMolecularFunctionchannel activity

PIEZO2 SLC26A6 ITPR1 ITPR2 ITPR3

9.87e-03525505GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

PIEZO2 SLC26A6 ITPR1 ITPR2 ITPR3

9.95e-03526505GO:0022803
GeneOntologyBiologicalProcesscellular response to cAMP

SLC26A3 SLC26A6 ITPR1 ITPR2 ITPR3

1.79e-0753505GO:0071320
GeneOntologyBiologicalProcessoxalate transport

SLC26A3 SLC26A2 SLC26A6

2.90e-0612503GO:0019532
GeneOntologyBiologicalProcessresponse to cAMP

SLC26A3 SLC26A6 ITPR1 ITPR2 ITPR3

3.71e-0697505GO:0051591
GeneOntologyBiologicalProcesssulfate transmembrane transport

SLC26A3 SLC26A2 SLC26A6

7.34e-0616503GO:1902358
GeneOntologyBiologicalProcessresponse to organophosphorus

SLC26A3 SLC26A6 ITPR1 ITPR2 ITPR3

2.38e-05142505GO:0046683
GeneOntologyBiologicalProcessendocardium formation

SOX17 SOX18

3.44e-054502GO:0060214
GeneOntologyBiologicalProcessresponse to purine-containing compound

SLC26A3 SLC26A6 ITPR1 ITPR2 ITPR3

5.03e-05166505GO:0014074
GeneOntologyBiologicalProcessendocardial cell differentiation

SOX17 SOX18

8.59e-056502GO:0060956
GeneOntologyBiologicalProcessbicarbonate transport

SLC26A3 SLC26A2 SLC26A6

1.07e-0438503GO:0015701
GeneOntologyBiologicalProcessendocardium morphogenesis

SOX17 SOX18

1.20e-047502GO:0003160
GeneOntologyBiologicalProcessstem cell fate specification

SOX17 SOX18

1.20e-047502GO:0048866
GeneOntologyBiologicalProcesscardiac endothelial cell differentiation

SOX17 SOX18

1.60e-048502GO:0003348
GeneOntologyBiologicalProcessintracellular pH elevation

SLC26A3 SLC26A6

1.60e-048502GO:0051454
GeneOntologyBiologicalProcessnoradrenergic neuron differentiation

SOX4 SOX11

3.12e-0411502GO:0003357
GeneOntologyBiologicalProcessstem cell fate commitment

SOX17 SOX18

3.12e-0411502GO:0048865
GeneOntologyBiologicalProcessepithelial fluid transport

SLC26A6 ITPR1

3.74e-0412502GO:0042045
GeneOntologyBiologicalProcesspositive regulation of gamma-delta T cell differentiation

SOX4 SOX13

3.74e-0412502GO:0045588
GeneOntologyBiologicalProcessendocardium development

SOX17 SOX18

4.42e-0413502GO:0003157
GeneOntologyBiologicalProcesspositive regulation of gamma-delta T cell activation

SOX4 SOX13

5.14e-0414502GO:0046645
GeneOntologyBiologicalProcesssulfur compound transport

SLC26A3 SLC26A2 SLC26A6

5.27e-0465503GO:0072348
GeneOntologyBiologicalProcessdetermination of left/right symmetry

DPCD SOX17 SOX18 DNAH11

5.27e-04154504GO:0007368
GeneOntologyBiologicalProcessregulation of gamma-delta T cell differentiation

SOX4 SOX13

5.93e-0415502GO:0045586
GeneOntologyBiologicalProcessleft/right pattern formation

DPCD SOX17 SOX18 DNAH11

6.37e-04162504GO:0060972
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

SLC26A3 HAMP SLC26A6 INPP4B ITPR1 ITPR2 ITPR3

6.39e-04611507GO:0030003
GeneOntologyBiologicalProcessdetermination of bilateral symmetry

DPCD SOX17 SOX18 DNAH11

6.83e-04165504GO:0009855
GeneOntologyBiologicalProcessspecification of symmetry

DPCD SOX17 SOX18 DNAH11

6.83e-04165504GO:0009799
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

SLC26A3 HAMP SLC26A6 INPP4B ITPR1 ITPR2 ITPR3

7.10e-04622507GO:0006873
GeneOntologyBiologicalProcessregulation of gamma-delta T cell activation

SOX4 SOX13

7.65e-0417502GO:0046643
GeneOntologyBiologicalProcessintracellular chemical homeostasis

SOX4 SLC26A3 HAMP SLC26A6 INPP4B ITPR1 ITPR2 ITPR3

1.05e-03866508GO:0055082
GeneOntologyBiologicalProcessheart morphogenesis

SOX4 SOX11 SOX17 SOX18 DNAH11

1.06e-03321505GO:0003007
GeneOntologyBiologicalProcessgamma-delta T cell differentiation

SOX4 SOX13

1.06e-0320502GO:0042492
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR1 ITPR2 ITPR3

1.07e-069503GO:0031095
GeneOntologyCellularComponentplatelet dense tubular network

ITPR1 ITPR2 ITPR3

2.10e-0611503GO:0031094
DomainHMG_box

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 SOX13

4.83e-1153467PF00505
DomainHMG_BOX_2

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 SOX13

5.54e-1154467PS50118
DomainHMG

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 SOX13

5.54e-1154467SM00398
DomainZnF_C2HC

XRN2 FAM90A14 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10

6.33e-1155467SM00343
Domain-

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 SOX13

6.33e-11554671.10.30.10
DomainZnf_CCHC

XRN2 FAM90A14 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10

6.33e-1155467IPR001878
DomainHMG_box_dom

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 SOX13

2.13e-1065467IPR009071
DomainSox7/17/18_central

SOX7 SOX17 SOX18

1.40e-083463IPR033392
DomainInsP3_rcpt-bd

ITPR1 ITPR2 ITPR3

1.40e-083463IPR000493
DomainSox17_18_mid

SOX7 SOX17 SOX18

1.40e-083463PF12067
DomainSox_C

SOX7 SOX17 SOX18

1.40e-083463IPR021934
DomainSOX_C

SOX7 SOX17 SOX18

1.40e-083463PS51516
DomainRIH_assoc

ITPR1 ITPR2 ITPR3

2.78e-076463PF08454
DomainRIH_assoc-dom

ITPR1 ITPR2 ITPR3

2.78e-076463IPR013662
DomainRYDR_ITPR

ITPR1 ITPR2 ITPR3

2.78e-076463PF01365
DomainRIH_dom

ITPR1 ITPR2 ITPR3

2.78e-076463IPR000699
DomainIns145_P3_rcpt

ITPR1 ITPR2 ITPR3

2.78e-076463IPR014821
DomainRyanodine_recept-rel

ITPR1 ITPR2 ITPR3

2.78e-076463IPR015925
DomainIns145_P3_rec

ITPR1 ITPR2 ITPR3

2.78e-076463PF08709
Domain-

ITPR1 ITPR2 ITPR3

2.78e-0764631.25.10.30
DomainS04_transporter_CS

SLC26A3 SLC26A2 SLC26A6

4.86e-077463IPR018045
DomainMIR

ITPR1 ITPR2 ITPR3

1.66e-0610463PS50919
DomainMIR

ITPR1 ITPR2 ITPR3

1.66e-0610463PF02815
DomainMIR

ITPR1 ITPR2 ITPR3

1.66e-0610463SM00472
DomainMIR_motif

ITPR1 ITPR2 ITPR3

1.66e-0610463IPR016093
DomainSLC26A

SLC26A3 SLC26A2 SLC26A6

1.66e-0610463PS01130
DomainSTAS

SLC26A3 SLC26A2 SLC26A6

2.28e-0611463PS50801
DomainSLC26A/SulP_fam

SLC26A3 SLC26A2 SLC26A6

2.28e-0611463IPR001902
DomainSTAS_dom

SLC26A3 SLC26A2 SLC26A6

2.28e-0611463IPR002645
Domain-

SLC26A3 SLC26A2 SLC26A6

2.28e-06114633.30.750.24
DomainSLC26A/SulP_dom

SLC26A3 SLC26A2 SLC26A6

2.28e-0611463IPR011547
DomainSulfate_transp

SLC26A3 SLC26A2 SLC26A6

2.28e-0611463PF00916
DomainSTAS

SLC26A3 SLC26A2 SLC26A6

2.28e-0611463PF01740
DomainFA58C

EDIL3 F8

1.21e-0321462SM00231
DomainFA58C_3

EDIL3 F8

1.21e-0321462PS50022
DomainFA58C_1

EDIL3 F8

1.21e-0321462PS01285
DomainFA58C_2

EDIL3 F8

1.21e-0321462PS01286
DomainF5_F8_type_C

EDIL3 F8

1.58e-0324462PF00754
DomainFA58C

EDIL3 F8

1.58e-0324462IPR000421
DomainIon_trans_dom

ITPR1 ITPR2 ITPR3

2.78e-03114463IPR005821
DomainIon_trans

ITPR1 ITPR2 ITPR3

2.78e-03114463PF00520
DomainGDS_CDC24_CS

ARHGEF1 NGEF

4.15e-0339462IPR001331
DomainPH

CNKSR1 CDC42BPA ARHGEF1 NGEF

4.80e-03278464SM00233
DomainPH_DOMAIN

CNKSR1 CDC42BPA ARHGEF1 NGEF

4.86e-03279464PS50003
DomainPH_domain

CNKSR1 CDC42BPA ARHGEF1 NGEF

4.92e-03280464IPR001849
Domain-

C2CD4C SNRNP200 INPP4B

5.77e-031484632.60.40.150
DomainC2_dom

C2CD4C SNRNP200 INPP4B

7.65e-03164463IPR000008
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

SOX3 SOX4 SOX7 SOX17 SOX13

1.15e-0832345MM14975
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

SOX3 SOX4 SOX7 SOX17 SOX13

4.79e-0842345M27272
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.28e-075343M49000
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

2.55e-076343M47960
PathwayREACTOME_SIGNALING_BY_WNT

SOX3 SOX4 SOX7 SOX17 SOX13 ITPR1 ITPR2 ITPR3

8.84e-07330348M7847
PathwayREACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS

SLC26A3 SLC26A2 SLC26A6

1.07e-069343M27344
PathwayREACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS

SLC26A3 SLC26A2 SLC26A6

1.07e-069343MM15084
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.07e-069343M47852
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.52e-0610343M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

2.09e-0611343M49033
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR1 ITPR2 ITPR3

2.09e-0611343M27466
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

3.61e-0613343M47696
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

3.61e-0613343M47751
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

3.61e-0613343M47656
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2 ITPR3

3.61e-0613343MM14553
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2 ITPR3

7.03e-0616343M26945
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

ITPR1 ITPR2 ITPR3

1.21e-0519343M27423
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.21e-0519343M47760
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.21e-0519343M47733
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.42e-0520343M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.66e-0521343M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.91e-0522343M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.91e-0522343M47675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

2.20e-0523343M47676
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2 ITPR3

2.84e-0525343MM14511
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

INPP4B ITPR1 ITPR2 ITPR3

3.20e-0576344M9052
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

SOX3 SOX4 SOX7 SOX17 SOX13

3.55e-05158345MM14791
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2 ITPR3

3.60e-0527343M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

3.60e-0527343MM15053
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

4.03e-0528343M924
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2 ITPR3

6.06e-0532343MM14983
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

ITPR1 ITPR2 ITPR3

8.67e-0536343M1315
PathwayWP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION

ITPR1 ITPR2 ITPR3

8.67e-0536343M39831
PathwayREACTOME_DAG_AND_IP3_SIGNALING

ITPR1 ITPR2 ITPR3

1.28e-0441343M512
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2 ITPR3

1.38e-0442343M791
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

ITPR1 ITPR2 ITPR3

1.59e-0444343M39845
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

ARHGEF1 ITPR1 ITPR2 ITPR3

1.61e-04115344M9387
PathwaySIG_CHEMOTAXIS

ITPR1 ITPR2 ITPR3

1.70e-0445343M5193
PathwaySIG_BCR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.81e-0446343M8626
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

SOX3 SOX4 SOX7 SOX17 SOX13

2.22e-04233345M27099
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

2.33e-0450343M47951
PathwayREACTOME_SIGNALING_BY_WNT

SOX3 SOX4 SOX7 SOX17 SOX13

2.50e-04239345MM14756
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

ITPR1 ITPR2 ITPR3

2.77e-0453343MM15716
PathwayREACTOME_ION_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

2.92e-0454343M27460
PathwayREACTOME_ION_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

2.92e-0454343MM15202
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

ITPR1 ITPR2 ITPR3

2.92e-0454343M26911
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

3.09e-0455343M47952
PathwayREACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION

SERPINA4 F8 ITPR1 ITPR2 ITPR3

3.75e-04261345M1077
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

ITPR1 ITPR2 ITPR3

4.19e-0461343MM15071
PathwayREACTOME_CA2_PATHWAY

ITPR1 ITPR2 ITPR3

4.40e-0462343M27321
PathwayKEGG_LONG_TERM_POTENTIATION

ITPR1 ITPR2 ITPR3

6.28e-0470343M3115
PathwayKEGG_LONG_TERM_DEPRESSION

ITPR1 ITPR2 ITPR3

6.28e-0470343M8232
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

ITPR1 ITPR2 ITPR3

6.82e-0472343MM14631
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

ITPR1 ITPR2 ITPR3

7.39e-0474343M48080
PathwayWP_ALZHEIMERS_DISEASE

ITPR1 ITPR2 ITPR3

7.39e-0474343MM15962
PathwayREACTOME_PLATELET_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

7.99e-0476343MM15051
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

ITPR1 ITPR2 ITPR3

8.62e-0478343M1921
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

ITPR1 ITPR2 ITPR3

9.97e-0482343M27110
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

ITPR1 ITPR2 ITPR3

1.14e-0386343M27206
PathwayREACTOME_PLATELET_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

1.14e-0386343M916
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

ITPR1 ITPR2 ITPR3

1.14e-0386343M601
PathwayWP_GDNFRET_SIGNALING_AXIS

SOX11 SOX17

1.27e-0322342MM15887
PathwayKEGG_GAP_JUNCTION

ITPR1 ITPR2 ITPR3

1.30e-0390343M4013
PathwayREACTOME_OPIOID_SIGNALLING

ITPR1 ITPR2 ITPR3

1.30e-0390343M6467
PathwayWP_GDNFRET_SIGNALING_AXIS

SOX11 SOX17

1.38e-0323342M39814
PathwayREACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS

ITPR1 ITPR2 ITPR3

1.52e-0395343M29842
PathwayREACTOME_CLEC7A_DECTIN_1_SIGNALING

ITPR1 ITPR2 ITPR3

1.77e-03100343M27467
PathwayKEGG_GNRH_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.82e-03101343M1979
PathwayREACTOME_CARDIAC_CONDUCTION

ITPR1 ITPR2 ITPR3

1.92e-03103343MM15196
PathwayREACTOME_SIGNALING_BY_VEGF

ITPR1 ITPR2 ITPR3

2.09e-03106343M27077
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

ITPR1 ITPR2 ITPR3

2.20e-03108343M17034
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC26A3 SLC26A2 SLC26A6

2.20e-03108343M823
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC26A3 SLC26A2 SLC26A6

2.26e-03109343MM15074
PathwayKEGG_OOCYTE_MEIOSIS

ITPR1 ITPR2 ITPR3

2.50e-03113343M16817
PathwayREACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION

F8 ITPR1 ITPR2 ITPR3

3.26e-03257344MM15454
PathwayREACTOME_CARDIAC_CONDUCTION

ITPR1 ITPR2 ITPR3

3.72e-03130343M27454
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

ITPR1 ITPR2 ITPR3

3.80e-03131343MM15717
PathwayREACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION

ITPR1 ITPR2 ITPR3

4.05e-03134343M29840
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

ITPR1 ITPR2 ITPR3

4.58e-03140343M27484
PathwayREACTOME_RHOA_GTPASE_CYCLE

ARHGEF1 NGEF DIAPH3

4.76e-03142343MM15576
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

ITPR1 ITPR2 ITPR3

4.86e-03143343M27107
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

ITPR1 ITPR2 ITPR3

5.15e-03146343M27288
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

ITPR1 ITPR2 ITPR3

5.25e-03147343MM15854
PathwayREACTOME_RHOA_GTPASE_CYCLE

ARHGEF1 NGEF DIAPH3

5.45e-03149343M41805
PathwayPID_RHOA_REG_PATHWAY

ARHGEF1 NGEF

5.47e-0346342M68
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

ITPR1 ITPR2 ITPR3

5.65e-03151343M39329
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

ITPR1 ITPR2 ITPR3

5.97e-03154343MM15974
PathwayREACTOME_CDC42_GTPASE_CYCLE

CDC42BPA NGEF DIAPH3

6.08e-03155343M41808
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

ITPR1 ITPR2 ITPR3

6.19e-03156343M39475
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

ARHGEF1 NGEF

6.94e-0352342MM14743
PathwayREACTOME_MUSCLE_CONTRACTION

ITPR1 ITPR2 ITPR3

7.22e-03165343MM15026
PathwayKEGG_ALZHEIMERS_DISEASE

ITPR1 ITPR2 ITPR3

7.34e-03166343M16024
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

ITPR1 ITPR2 ITPR3

7.34e-03166343M608
PathwayREACTOME_RHOJ_GTPASE_CYCLE

CDC42BPA DIAPH3

7.74e-0355342M41815
PathwayREACTOME_RAC1_GTPASE_CYCLE

CDC42BPA NGEF DIAPH3

8.48e-03175343MM15599
PathwayREACTOME_RHOQ_GTPASE_CYCLE

CDC42BPA DIAPH3

8.58e-0358342MM15602
PathwayREACTOME_RHOQ_GTPASE_CYCLE

CDC42BPA DIAPH3

8.86e-0359342M41812
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

ARHGEF1 NGEF

8.86e-0359342M11215
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

8.89e-03178343M2890
PathwayREACTOME_RAC1_GTPASE_CYCLE

CDC42BPA NGEF DIAPH3

9.73e-03184343M41809
Pubmed

Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.

FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10

1.49e-2525531117684299
Pubmed

Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.

FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A16 FAM90A10

3.09e-2323531018602769
Pubmed

Spatio-temporal expression of Sox genes in murine palatogenesis.

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 SOX13

2.43e-161753727241892
Pubmed

Expression of Sox genes in tooth development.

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 SOX13

3.97e-161853726864488
Pubmed

Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.

FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 DIAPH3 HAMP FAM90A7 FAM90A9 FAM90A8 FAM90A10

1.17e-15164531122967998
Pubmed

Expression of Sox transcription factors in the developing mouse pancreas.

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 SOX13

1.44e-152153712815626
Pubmed

Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.

SOX3 SOX4 SOX11 SOX17 SOX18 SOX13

1.59e-141353612194848
Pubmed

Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.

SOX4 SOX11 SOX7 SOX17 SOX18 SOX13

2.78e-14145368921394
Pubmed

Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.

SOX4 SOX11 SOX17 SOX18 SOX13

8.49e-13953512100890
Pubmed

Seven new members of the Sox gene family expressed during mouse development.

SOX3 SOX4 SOX11 SOX7 SOX13

8.63e-12135358441686
Pubmed

Differential isoform expression and alternative splicing in sex determination in mice.

SOX3 SOX4 SOX11 SOX7 SOX13

2.01e-111553530871468
Pubmed

A conserved family of genes related to the testis determining gene, SRY.

SOX3 SOX4 SOX7 SOX18

3.35e-1085341614875
Pubmed

A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings.

SOX3 SOX4 SOX11 SOX7 SOX17

3.51e-102553519369396
Pubmed

From head to toes: the multiple facets of Sox proteins.

SOX3 SOX4 SOX11 SOX13

1.00e-091053410037800
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR1 ITPR2 ITPR3

3.34e-09353310874040
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR1 ITPR2 ITPR3

3.34e-0935339808793
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR1 ITPR2 ITPR3

3.34e-09353320395455
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR1 ITPR2 ITPR3

3.34e-09353317437169
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR1 ITPR2 ITPR3

3.34e-09353318194433
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR1 ITPR2 ITPR3

3.34e-09353318547250
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR1 ITPR2 ITPR3

3.34e-09353336350267
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR1 ITPR2 ITPR3

3.34e-09353327777977
Pubmed

The versatility and universality of calcium signalling.

ITPR1 ITPR2 ITPR3

3.34e-09353311413485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

3.34e-09353326009177
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR1 ITPR2 ITPR3

3.34e-09353317581770
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR1 ITPR2 ITPR3

3.34e-09353318241669
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR1 ITPR2 ITPR3

3.34e-0935331693919
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR1 ITPR2 ITPR3

3.34e-09353319068129
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR1 ITPR2 ITPR3

3.34e-09353323955339
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR1 ITPR2 ITPR3

3.34e-09353331979185
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR1 ITPR2 ITPR3

3.34e-09353324904548
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

3.34e-09353317327232
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR1 ITPR2 ITPR3

3.34e-09353316014380
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR1 ITPR2 ITPR3

3.34e-09353317890015
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR1 ITPR2 ITPR3

3.34e-09353323983250
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR1 ITPR2 ITPR3

3.34e-0935339858485
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR1 ITPR2 ITPR3

3.34e-09353320427533
Pubmed

Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.

SOX7 SOX17 SOX18 EDIL3

6.48e-091553426630461
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR1 ITPR2 ITPR3

1.34e-08453325215520
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR1 ITPR2 ITPR3

1.34e-08453321424589
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR1 ITPR2 ITPR3

1.34e-08453328615414
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR1 ITPR2 ITPR3

1.34e-08453310828023
Pubmed

Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos.

SOX7 SOX17 SOX18

1.34e-08453317610846
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR1 ITPR2 ITPR3

1.34e-08453328419336
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

1.34e-08453311163362
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR1 ITPR2 ITPR3

1.34e-08453335494252
Pubmed

SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development.

SOX7 SOX17 SOX18

1.34e-08453328619820
Pubmed

Molecular evolution of Sry and Sox gene.

SOX3 SOX4 SOX18 SOX13

2.29e-082053411404013
Pubmed

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.

SOX4 SOX11 SOX7 SOX13

2.82e-082153416306355
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR1 ITPR2 ITPR3

3.33e-08553321568942
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

ITPR1 ITPR2 ITPR3

6.66e-08653323463619
Pubmed

Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.

ITPR1 ITPR2 ITPR3

6.66e-08653321762810
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

ITPR1 ITPR2 ITPR3

6.66e-08653320519450
Pubmed

Sox gene expression during neuronal development.

SOX3 SOX4 SOX11

6.66e-0865337821514
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

ITPR1 ITPR2 ITPR3

6.66e-08653325966694
Pubmed

Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice.

SOX7 SOX17 SOX18

6.66e-08653319515696
Pubmed

Sox17 is essential for proper formation of the marginal zone of extraembryonic endoderm adjacent to a developing mouse placental disk.

SOX7 SOX17 SOX18

6.66e-08653329635272
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

ITPR1 ITPR2 ITPR3

6.66e-08653316844763
Pubmed

Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger.

SLC26A3 SLC26A2 SLC26A6

6.66e-08653311087667
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

ITPR1 ITPR2 ITPR3

1.16e-07753311860456
Pubmed

SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development.

SOX7 SOX17 SOX18

1.16e-07753328577909
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

ITPR1 ITPR2 ITPR3

1.16e-07753322495310
Pubmed

Physiological roles and regulation of mammalian sulfate transporters.

SLC26A3 SLC26A2 SLC26A6

2.79e-07953311581495
Pubmed

Placental, renal, and ileal sulfate transporter gene expression in mouse gestation.

SLC26A3 SLC26A2 SLC26A6

2.79e-07953322674389
Pubmed

A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse.

SOX7 SOX17 EDIL3

2.79e-07953330530745
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

ITPR1 ITPR2 ITPR3

2.79e-07953325737585
Pubmed

N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins.

SLC26A3 SLC26A2 SLC26A6

3.98e-071053324647542
Pubmed

The expression of Sox17 identifies and regulates haemogenic endothelium.

SOX7 SOX17 SOX18

5.47e-071153323604320
Pubmed

The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.

SOX7 SOX17 EDIL3

5.47e-071153321146513
Pubmed

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.

ITPR1 ITPR2 ITPR3

5.47e-071153327514653
Pubmed

Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.

SOX3 SOX4 SOX11

7.28e-071253311071752
Pubmed

Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice.

SOX7 SOX17 SOX18

7.28e-071253316895970
Pubmed

Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.

SOX4 SOX11 SOX13

7.28e-07125337590241
Pubmed

Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.

SOX7 SOX17 SOX18

9.45e-071353322962592
Pubmed

Deciphering the Sox-Oct partner code by quantitative cooperativity measurements.

SOX4 SOX17 SOX18

9.45e-071353322344693
Pubmed

Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.

ITPR1 ITPR2 ITPR3

1.20e-061453334630045
Pubmed

Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types.

SOX7 SOX17 SOX18

1.50e-061553328512199
Pubmed

SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity.

SOX7 SOX17 SOX18

1.50e-061553329882512
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

ITPR1 ITPR2 ITPR3

1.50e-061553328578927
Pubmed

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

ITPR2 ITPR3

2.28e-0625329065779
Pubmed

Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.

ITPR2 ITPR3

2.28e-06253217496801
Pubmed

Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.

ITPR1 ITPR3

2.28e-0625328663526
Pubmed

Induction of enteric oxalate secretion by Oxalobacter formigenes in mice does not require the presence of either apical oxalate transport proteins Slc26A3 or Slc26A6.

SLC26A3 SLC26A6

2.28e-06253231201468
Pubmed

Differential expression of SOX4 and SOX11 in medulloblastoma.

SOX4 SOX11

2.28e-06253212125983
Pubmed

Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6.

SLC26A3 SLC26A6

2.28e-06253216606687
Pubmed

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.

ITPR1 ITPR3

2.28e-06253215890645
Pubmed

Sulfate secretion and chloride absorption are mediated by the anion exchanger DRA (Slc26a3) in the mouse cecum.

SLC26A3 SLC26A6

2.28e-06253223660504
Pubmed

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

ITPR2 ITPR3

2.28e-06253224901844
Pubmed

SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.

SOX4 SOX11

2.28e-06253222378879
Pubmed

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

ITPR2 ITPR3

2.28e-06253233854148
Pubmed

Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis.

SLC26A3 SLC26A6

2.28e-06253228526688
Pubmed

An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.

ITPR1 ITPR2

2.28e-06253218708078
Pubmed

Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.

ITPR1 ITPR2

2.28e-06253215201137
Pubmed

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

ITPR2 ITPR3

2.28e-06253219528657
Pubmed

Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse.

SLC26A3 SLC26A6

2.28e-06253230118583
Pubmed

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

ITPR2 ITPR3

2.28e-0625328063813
Pubmed

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

2.28e-0625328081734
Pubmed

Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.

ITPR1 ITPR2

2.28e-06253223582047
Pubmed

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

ITPR1 ITPR3

2.28e-0625321374893
Pubmed

Involvement of Cl(-)/HCO3(-) exchanger SLC26A3 and SLC26A6 in preimplantation embryo cleavage.

SLC26A3 SLC26A6

2.28e-06253227346053
InteractionIRAG1 interactions

ITPR1 ITPR2 ITPR3

2.80e-0614413int:IRAG1
InteractionTESPA1 interactions

ITPR1 ITPR2 ITPR3

4.30e-0616413int:TESPA1
InteractionTRPC4 interactions

ITPR1 ITPR2 ITPR3

1.35e-0523413int:TRPC4
InteractionRASEF interactions

ITPR1 ITPR2 ITPR3

1.74e-0525413int:RASEF
InteractionTRPC1 interactions

ITPR1 ITPR2 ITPR3

2.75e-0529413int:TRPC1
InteractionBBOX1 interactions

ITPR1 ITPR2 ITPR3

2.75e-0529413int:BBOX1
InteractionTRPC2 interactions

ITPR1 ITPR3

4.02e-055412int:TRPC2
InteractionRHOA interactions

CNKSR1 GANAB CDC42BPA ARHGEF1 NGEF DIAPH3 SLC26A6 ITPR1 ITPR2 ITPR3

1.10e-0411994110int:RHOA
InteractionSOX11 interactions

SOX11 SOX13

1.12e-048412int:SOX11
InteractionTAFA4 interactions

ITPR1 ITPR2 ITPR3

1.91e-0455413int:TAFA4
InteractionDUSP26 interactions

GANAB SNRNP200 ITPR3

2.35e-0459413int:DUSP26
InteractionRHOB interactions

CNKSR1 GANAB CDC42BPA SLC26A2 ARHGEF1 DIAPH3 C2CD4C SLC26A6

2.48e-04840418int:RHOB
InteractionPXMP2 interactions

GANAB SLC26A6 ITPR1 ITPR2 ITPR3

2.53e-04281415int:PXMP2
InteractionCABP2 interactions

ITPR1 ITPR2 ITPR3

2.59e-0461413int:CABP2
InteractionBANK1 interactions

ITPR1 ITPR2

2.63e-0412412int:BANK1
InteractionSOX5 interactions

SOX11 SOX7 XRN2 SOX13

3.23e-04162414int:SOX5
CytobandEnsembl 112 genes in cytogenetic band chr8p23

SOX7 DLGAP2 FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10

7.86e-192345313chr8p23
Cytoband8p23.1

FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10

2.84e-1715453118p23.1
Cytoband1p36.21

PRAMEF33 PRAMEF10

2.44e-03635321p36.21
GeneFamilySRY-boxes

SOX3 SOX4 SOX11 SOX7 SOX17 SOX18 SOX13

2.62e-1619267757
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR2 ITPR3

2.64e-093263297
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

C2CD4C INPP4B

1.22e-0336262823
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF1 NGEF

4.03e-0366262722
GeneFamilySolute carriers

SLC26A3 SLC26A2 SLC26A6

1.85e-02395263752
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR3

2.77e-02181262694
CoexpressionAtlaskidney_e15.5_SmlBldVes_Tie2_k-means-cluster#4_top-relative-expression-ranked_500

SOX7 SOX17 SOX18 F8 INPP4B

3.14e-05190415gudmap_kidney_e15.5_SmlBldVes_Tie2_k4_500
CoexpressionAtlasdev gonad_e11.5_M_ReproVasc_Flk_k-means-cluster#3_top-relative-expression-ranked_500

SOX7 PIEZO2 SOX17 SOX18 INPP4B

7.17e-05226415gudmap_dev gonad_e11.5_M_ReproVasc_Flk_k3_500
CoexpressionAtlasdev gonad_e11.5_F_ReproVasc_Flk_k-means-cluster#4_top-relative-expression-ranked_500

SOX7 PIEZO2 SOX17 SOX18 INPP4B

7.63e-05229415gudmap_dev gonad_e11.5_F_ReproVasc_Flk_k4_500
CoexpressionAtlaskidney_e15.5_SmlBldVes_Tie2_top-relative-expression-ranked_500

SOX7 PIEZO2 SOX17 SOX18 F8 INPP4B

1.32e-04413416gudmap_kidney_e15.5_SmlBldVes_Tie2_500
CoexpressionAtlasdev gonad_e12.5_F_DevVasOvary_Flk_top-relative-expression-ranked_500

SOX7 PIEZO2 SOX17 SOX18 EDIL3 INPP4B

1.35e-04415416gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_500
CoexpressionAtlaskidney_e15.5_SmlBldVes_Tie2_k-means-cluster#4_top-relative-expression-ranked_1000

SOX7 SOX17 SOX18 F8 INPP4B

2.19e-04287415gudmap_kidney_e15.5_SmlBldVes_Tie2_k4_1000
CoexpressionAtlasdev gonad_e12.5_M_DevVasTestis_Flk_k-means-cluster#2_top-relative-expression-ranked_500

SOX7 PIEZO2 SOX17 SOX18 INPP4B

2.61e-04298415gudmap_dev gonad_e12.5_M_gudmap_devVasTestis_Flk_k2_500
CoexpressionAtlaskidney_adult_RenMedVasc_Tie2_k-means-cluster#2_top-relative-expression-ranked_1000

SOX7 SOX17 SOX18 MEF2A F8

3.22e-04312415gudmap_kidney_adult_RenMedVasc_Tie2_k2_1000
CoexpressionAtlasdev gonad_e12.5_F_DevVasOvary_Flk_top-relative-expression-ranked_200

SOX7 PIEZO2 SOX17 SOX18

3.64e-04176414gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_200
CoexpressionAtlasdev gonad_e13.5_F_DevVascOvary_Flk_top-relative-expression-ranked_200

SOX7 PIEZO2 SOX17 SOX18

3.88e-04179414gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_200
CoexpressionAtlasdev gonad_e11.5_M_ReproVasc_Flk_k-means-cluster#4_top-relative-expression-ranked_1000

SOX7 PIEZO2 SOX17 SOX18 EDIL3 INPP4B

4.28e-04514416gudmap_dev gonad_e11.5_M_ReproVasc_Flk_k4_1000
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SOX11 SOX7 PIEZO2 SOX17 SOX18 EDIL3 SOX13

4.33e-101814379cd5e5c285c2b628db9d59709af053defd7c0aff
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)|368C / Donor, Lineage, Cell class and subclass (all cells)

SOX7 SOX17 SOX18 C2CD4C F8 ITPR1

1.61e-0817343622200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)-|368C / Donor, Lineage, Cell class and subclass (all cells)

SOX7 SOX17 SOX18 C2CD4C F8 ITPR1

1.61e-08173436ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCellPND07-28-samps-Endothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SOX11 SOX7 PIEZO2 SOX17 SOX18 SOX13

2.72e-08189436eb2f8c8a90e5e9f6697a2d13274c94f40e1973e4
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SOX11 SOX7 PIEZO2 SOX17 SOX18 SOX13

2.72e-08189436d4a25d59d88325d3b20f4287e9b1160c82961a96
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial|PND01-03-samps / Age Group, Lineage, Cell class and subclass

SOX11 SOX7 PIEZO2 SOX17 SOX18 EDIL3

2.81e-081904365130fb325f80f591b9b36beacb8072c4472304f2
ToppCellPND01-03-samps-Endothelial|PND01-03-samps / Age Group, Lineage, Cell class and subclass

SOX11 SOX7 PIEZO2 SOX17 SOX18 EDIL3

2.81e-081904361357bd4527399d7013ee33272bda7453f472999a
ToppCellfacs-Aorta-Heart-3m-Endothelial-aorta_endothelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 SOX18 EDIL3 MEF2A F8 INPP4B

3.27e-081954363969b8d5fcec8ef1831531a781f7bbcebab5a4ba
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SOX7 SOX17 SOX18 C2CD4C F8 ITPR1

3.69e-08199436fff88d2bba262583bb726900ae01e44954b72eb9
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SOX7 SOX17 SOX18 C2CD4C F8 ITPR1

3.80e-08200436e90ca26643f8496bdd6672c327da9855490d1aa8
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Thalamus / BrainAtlas - Mouse McCarroll V32

SOX7 SOX17 SOX18 HAMP ITPR3

1.84e-0713343529b0c2c682c6b97823e7d8d8ba1f5114044b30ba
ToppCellfacs-Aorta|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX17 SOX18 EDIL3 F8 DNAH11

7.38e-071764350b3491451be02c18a16cdb875645be47eb867a7f
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 SOX7 SOX17 SOX18 ITPR3

7.38e-0717643527e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 SOX7 SOX17 SOX18 ITPR3

7.38e-07176435d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Proliferative_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

SOX7 PIEZO2 SOX17 SOX18 EDIL3

8.03e-07179435d24513a404c9b1d37dd47aa1cdb5713b64b88f89
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial|E18.5-samps / Age Group, Lineage, Cell class and subclass

SOX7 PIEZO2 SOX17 SOX18 EDIL3

8.71e-071824357af3b2029b7f55b923d5a4b764d4292f4ea48599
ToppCellE18.5-samps-Endothelial|E18.5-samps / Age Group, Lineage, Cell class and subclass

SOX7 PIEZO2 SOX17 SOX18 EDIL3

8.71e-07182435e2d799e6e7526176a6fe6515b8fbe4d83d3a3ea1
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 CDC42BPA SOX17 SOX18 ITPR3

1.08e-06190435d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOX11 SOX7 PIEZO2 SOX17 SOX18

1.10e-0619143538fe60a8570f3c6eb8e8f8646f90d505dfd7d647
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

SOX7 PIEZO2 SOX17 SOX18 EDIL3

1.10e-0619143544c596984c6196f6014e0e405dbe5560841e54ff
ToppCell10x5'v1-week_12-13-Endothelial-stroma-tip_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SOX11 SOX7 PIEZO2 SOX17 SOX18

1.10e-06191435cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOX11 SOX7 PIEZO2 SOX17 SOX18

1.10e-061914350e6cd2628a5cebd35e960e4eb3b52ddc9358031c
ToppCell(4)_Endothelial_cells-(41)_EC-arteriolar|World / Cell class and subclass of bone marrow stroma cells in homeostatis

SOX11 SOX7 SOX17 SOX18 SOX13

1.10e-06191435718c83046668a7c33bd8319b45c56f8edb34cfe7
ToppCellE16.5-samps-Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

SOX7 PIEZO2 SOX17 SOX18 EDIL3

1.10e-06191435e7521d4d24f016d4e531cd492a7a69604f0c9e6f
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 CDC42BPA SOX17 SOX18 ITPR3

1.13e-06192435285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SOX7 PIEZO2 SOX17 SOX18

1.13e-061924354fc98f30f8e738816cd93101fbe8ac40889e302a
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SOX7 PIEZO2 SOX17 SOX18

1.13e-06192435be75783d9578974b662e1cb13bd3442a921fd50a
ToppCelldroplet-Lung-3m-Endothelial-capillary_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOX11 SOX7 SOX17 SOX18 EDIL3

1.16e-061934351b6317b740cad2439f08b9e9895426d861e7a161
ToppCelldroplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOX11 SOX7 SOX17 SOX18 EDIL3

1.16e-06193435f5861cfa4401b476229a7c61cd64abad79a4bbfc
ToppCellfacs-Kidney-nan-3m-Endothelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX7 PIEZO2 SOX17 SOX18 F8

1.19e-061944355fa2dfca32cca4abfda0af90b83f2b2a826f9b6e
ToppCellfacs-Kidney-nan-3m-Endothelial-fenestrated_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX7 PIEZO2 SOX17 SOX18 F8

1.19e-0619443504df35246287815bdd28adaf885bdb98cf49524e
ToppCellfacs-Kidney-nan-3m-Endothelial-Pecam____fenestrated_capillary_endothelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX7 PIEZO2 SOX17 SOX18 F8

1.19e-0619443590928d6c96c6304ae35dcc0275f7889de93da100
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX7 PIEZO2 SOX17 SOX18 EDIL3

1.19e-0619443546e36817fd1ed27af8013375214c38c9a9271640
ToppCellPND03-Endothelial-Endothelial_blood-vessel|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX7 PIEZO2 SOX17 SOX18 EDIL3

1.19e-06194435f93f5148b136819d87faef89707dbaba07d6c2b5
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SOX7 CDC42BPA SOX17 SOX18 F8

1.22e-06195435023e3c97dd3696d74f002ff8da0c04d876c82aef
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SOX7 SOX17 SOX18 SOX13

1.22e-06195435e5f14f6015ea5e6fa065f906ad22157e3de15c68
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SOX7 SOX17 SOX18 SOX13

1.22e-061954355b84fd5be31386eb1d6048bbf28626032361842e
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX7 CDC42BPA SOX17 SOX18 SOX13

1.22e-06195435b0979c1b5e4576468b8fe4e9027650859e598b34
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SOX7 SOX17 SOX18 SOX13

1.22e-0619543552b2bbf12e5f86c493f6634697aeb23a68cc916d
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DLGAP2 PIEZO2 SOX18 C2CD4C F8

1.25e-0619643509a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DLGAP2 PIEZO2 SOX18 C2CD4C F8

1.25e-06196435e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCellfacs-Lung-ENDOMUCIN|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SOX7 SOX17 SOX18 SOX13

1.25e-0619643569f03546c42c942ab8ac8746167c8d44d574b4c6
ToppCellPND03-Endothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX7 PIEZO2 SOX17 SOX18 EDIL3

1.25e-06196435a529681d822a95dd1980b7b1c71dc61aaf0baecd
ToppCellfacs-Lung-ENDOMUCIN-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SOX7 SOX17 SOX18 SOX13

1.25e-06196435f6df26ab9eebae893768a4f70a064ce9f60da93c
ToppCellTracheal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DLGAP2 PIEZO2 SOX18 C2CD4C F8

1.32e-06198435306e28d31fd587409a12dcccc6b2abd7dc9c2e0a
ToppCellTracheal-10x5prime-Endothelial-Endothelia_lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DLGAP2 PIEZO2 SOX18 C2CD4C F8

1.32e-0619843505429f18e1d74880c1835568c86177f661b3477a
ToppCellfacs-Lung-18m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOX7 ARHGEF1 SOX17 SOX18 SOX13

1.35e-06199435c11e0044d3cc37f6bb26df033ad4448b419addfc
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_capillary|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SOX7 SLC26A2 SOX17 SOX18 MEF2A

1.35e-06199435772b3f60b83e29b958e1e70dadfd9f058ed4cb7c
ToppCellParenchyma_COVID-19-Endothelial-TX-Capillary|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

SOX7 SLC26A2 SOX17 SOX18 F8

1.39e-062004356c0498a5868891e8e22c03469d00669b20249b1a
ToppCellParenchyma_COVID-19-Endothelial-TX-Artery|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

SOX7 SOX17 SOX18 SOX13 F8

1.39e-0620043534b279804475ea58fbb052b96f44128c082627a9
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Capillary|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SOX7 SLC26A2 SOX17 SOX18 F8

1.39e-06200435e9913511a129bb3cee85e7ebf565b951dab91542
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Artery|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SOX7 SOX17 SOX18 SOX13 F8

1.39e-062004358552cc7a439449b30b59760c3e8667217b9852b5
ToppCell10x5'v1-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SOX11 SOX7 PIEZO2 SOX17 SOX18

1.39e-0620043577ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCellParenchymal-10x3prime_v2-Endothelial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SOX7 SOX17 SOX18 MEF2A F8

1.39e-062004353b07cf1a4dff2e868f52382681a2030c1248caed
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Capillary-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SOX7 SLC26A2 SOX17 SOX18 F8

1.39e-062004357020045b933cb104fb99b79524cb0d4734b8636d
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_vascular|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SOX7 SOX17 SOX18 MEF2A F8

1.39e-0620043530dc7ffef2052ee8610cdca952ca12f240bcec50
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Artery-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SOX7 SOX17 SOX18 SOX13 F8

1.39e-0620043545c08f1befe78553bbadcc2fcffb6138306638f3
ToppCellStriatum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)|Striatum / BrainAtlas - Mouse McCarroll V32

CNKSR1 SOX17 SOX18 ITPR3

2.55e-06994340d5684978f34258d4eb4941eb6c60393a9bc84ed
ToppCellStriatum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)--|Striatum / BrainAtlas - Mouse McCarroll V32

CNKSR1 SOX17 SOX18 ITPR3

2.55e-06994341244f50bb66eea555a284ff5c35ac755d1e9080d
ToppCellStriatum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)-|Striatum / BrainAtlas - Mouse McCarroll V32

CNKSR1 SOX17 SOX18 ITPR3

2.55e-06994340c27df8ecc1956b056930da9ab1c96df7fb9f7b5
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_STALK|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SOX7 SOX17 SOX18 ITPR3

7.76e-06131434308ddb7fe113eac5dbeb9cb0b688d9e09275ce5e
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SOX7 SOX17 SOX18 ITPR3

7.99e-0613243406e7337de35bd7120655a22b6020604ad004c4e1
ToppCellStriatum-Endothelial-ENDOTHELIAL_STALK|Striatum / BrainAtlas - Mouse McCarroll V32

SOX7 SOX17 SOX18 ITPR3

9.26e-06137434d37f425b13bc046baa1f8619b98a16b936f88ff6
ToppCellStriatum-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Striatum / BrainAtlas - Mouse McCarroll V32

SOX7 SOX17 SOX18 ITPR3

9.26e-06137434306b11b3b9e5fd562d845fb5eaa4ac982864efce
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SOX3 SOX4 DIAPH3 ITPR2

1.32e-0515043470ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK|Thalamus / BrainAtlas - Mouse McCarroll V32

SOX7 SOX17 SOX18 ITPR3

1.51e-05155434fe6c4aba0e98cda84bf178aeac2e9fa834477f22
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX7 PIEZO2 DPCD SOX18

1.54e-051564341928c86deb3bcd01db4ae76919a351066aadb39a
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SOX7 SOX17 SOX18 ITPR3

1.71e-0516043404714d0b9bad4c11fa193ed168e2d84a4df39e2e
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

SOX17 SOX18 SOX13 F8

2.07e-051684348c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCellEndothelial-B-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

DLGAP2 PIEZO2 SOX18 F8

2.11e-051694348889c9e8af1ab0b093d57b69abd80b59b3461be9
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX7 SOX17 SOX18 F8

2.21e-05171434b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCellE12.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SOX7 SOX17 SOX18 EDIL3

2.27e-05172434ba99688e9f46671deccf824b1e77c6db0742d7df
ToppCellE12.5-Endothelial-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SOX7 SOX17 SOX18 EDIL3

2.27e-051724342136170f6e1204734cec7dbf7b32e7d5179b92b5
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DLGAP2 PIEZO2 C2CD4C F8

2.32e-051734347dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SOX7 SOX17 DIAPH3

2.37e-051744349d5dcd46cf346c381dea68ada6665f7fb68114a3
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SOX7 SOX17 DIAPH3

2.37e-0517443453cec5c666c45278a71c21dd9c62a052a97e0fdf
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX7 SOX17 SOX18 ITPR3

2.37e-0517443442735f6a8e5ec36dd3d35aceea6d37cf3eaa1871
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX17 SOX18 F8 ITPR2

2.37e-0517443418ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCell368C-Endothelial_cells-Endothelial-D|368C / Donor, Lineage, Cell class and subclass (all cells)

SOX7 SOX17 SOX18 F8

2.42e-05175434c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCell368C-Endothelial_cells-Endothelial-D-|368C / Donor, Lineage, Cell class and subclass (all cells)

SOX7 SOX17 SOX18 F8

2.42e-05175434ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 SOX7 SOX17 C2CD4C

2.48e-0517643477516048aefbe1f48e825052756df0c310c1c486
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 SOX7 SOX17 C2CD4C

2.48e-0517643496779273b94345250cf53ba671203345b43d9e00
ToppCellmetastatic_Lymph_Node-Endothelial_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

DLGAP2 PIEZO2 SOX17 SOX18

2.53e-0517743471bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SOX11 SOX7 SOX18 SOX13

2.53e-051774346da88c358b3a2e47fa3472217a38b6b00ad7b280
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX7 SOX17 SOX18 C2CD4C

2.59e-05178434360d7a987f91d6d721487a921824057ec31a7332
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D231|Adult / Lineage, Cell type, age group and donor

DLGAP2 PIEZO2 C2CD4C F8

2.59e-05178434c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CDC42BPA SOX17 SOX13 F8

2.65e-051794342a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell368C-Endothelial_cells-Endothelial-E|368C / Donor, Lineage, Cell class and subclass (all cells)

SOX7 SOX17 SOX18 F8

2.71e-051804348ab16a0b9053bffc07b569a4f9e71749f56dde7e
ToppCell368C-Endothelial_cells-Endothelial-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

SOX7 SOX17 SOX18 F8

2.71e-05180434394cd465b88429b70eebb2957480dffcbc51cfe7
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX7 SOX17 SOX18 F8

2.77e-051814342e15c46e8260bb04d8264478c19a707221996026
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX17 SOX18 SOX13 ITPR1

2.77e-051814340ba91575fe8851788cebc4cf5a6d76680bf586c5
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX7 SOX17 SOX18 F8

2.83e-051824340639011cdd1c437ea8b7230896a4e6e5d7244ac2
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SOX7 PIEZO2 SOX18 C2CD4C

2.83e-05182434997d37ca2af661c92a56add888762724dfccc890
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 SOX17 SOX18 ITPR3

2.89e-051834343427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCellEndothelial-A-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

SOX7 SOX17 SOX18 F8

2.89e-051834342c3f2c25c38f0598b4787d2ec335efe00fdc9751
ToppCell3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX7 SOX17 SOX18 C2CD4C

2.95e-05184434842473fa415575441b595073a994b6d621169776
ToppCell3'-Child09-12-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX11 PIEZO2 SOX18 F8

3.01e-051854349de1db2ce9e44956b1214daf6e1e161334679c88
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO2 EDIL3 SOX13 INPP4B

3.01e-0518543451dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell3'-Child09-12-SmallIntestine-Endothelial-lymphatic_endothelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX11 PIEZO2 SOX18 F8

3.01e-0518543418f5d9438c76e37988a7d17aa2a080af6bedbfc4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO2 EDIL3 SOX13 INPP4B

3.01e-05185434a8c02cec3c414f3a0da9f2d6d28ce563b0030705
Drugadenophostin A

ITPR2 ITPR3

3.48e-062432ctd:C085029
DrugIsocaffeine

ITPR1 ITPR3

3.48e-062432CID000001326
Drugadenophostin B

ITPR1 ITPR3

3.48e-062432CID000656722
Drugbenzene 1,2,4-trisphosphate

ITPR1 ITPR3

3.48e-062432CID000192376
Drug5-deoxy-5-fluoro-myo-inositol

ITPR1 ITPR3

1.04e-053432CID000195110
DrugCHEBI:697555

ITPR1 ITPR3

2.09e-054432CID009578246
DrugAC1Q7BER

ITPR1 ITPR3

5.20e-056432CID000005702
DrugTE 5

SOX7 SOX17 SOX18

6.36e-0541433CID003083341
Drug3-F-InsP3

ITPR1 ITPR3

7.27e-057432CID003035756
DrugBr2BAPTA

ITPR1 ITPR3

7.27e-057432CID003081001
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

ITPR1 ITPR3

7.27e-057432CID009547999
Drug9 mM of H

ITPR1 ITPR3

9.69e-058432CID000130464
Drugbasic copper carbonate

ITPR1 ITPR3

9.69e-058432CID000025503
DrugNs 004

ITPR1 ITPR3

9.69e-058432CID000162750
DrugF2 g

ITPR1 ITPR3

9.69e-058432CID006857713
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR1 ITPR2 ITPR3

5.03e-0712403DOID:1441 (implicated_via_orthology)
DiseaseAnoxic Encephalopathy

ITPR1 ITPR2

1.79e-062402C0003132
DiseaseBrain Hypoxia

ITPR1 ITPR2

1.79e-062402C1527348
DiseaseAnoxia of brain

ITPR1 ITPR2

1.79e-062402C0995195
DiseaseHypoxic Brain Damage

ITPR1 ITPR2

1.79e-062402C1140716
DiseaseCoffin-Siris syndrome

SOX4 SOX11

1.38e-0413402C0265338

Protein segments in the cluster

PeptideGeneStartEntry
MRRFEALKLMVQAWP

PRAMEF33

46

A0A0G2JMD5
DFRSKRLMGMTPWEQ

ARHGEF1

156

Q92888
HLSPQAELDFWMMRR

DNAH11

271

Q96DT5
QRLRLNDWKMMESPE

DLGAP2

966

Q9P1A6
MRRLNWLKIRPHEMT

DIAPH3

646

Q9NSV4
MRKTNMWFLERLRGS

C2CD4C

1

Q8TF44
MMARRDPKSWAKRLV

FAM90A10

1

A6NDY2
MRHGMEKIWRPNRVF

RAB40C

176

Q96S21
RSMKWSARAMIPRQR

PGBD4

71

Q96DM1
MMARRDPKSWAKRLV

FAM90A7

1

A6NKC0
QMIVEKNLDWFPRMR

ITPR2

2616

Q14571
KNLDWFPRMRAMSLV

ITPR2

2621

Q14571
NKNLDWFPRMRAMSL

ITPR3

2596

Q14573
MMARRDPKSWAKRLV

FAM90A23

1

A8MXZ1
KRLREMSPLWEMVQD

NFS1

431

Q9Y697
KERNLDWFPRMRAMS

ITPR1

2676

Q14643
FPTSDNKWMRIREQM

INPP4B

241

O15327
MMARRDPKSWAKRLV

FAM90A22

1

A8MWA6
MMARRDPTSWAKRLV

FAM90A14

1

P0C7W9
MQDRDAASARAWPKM

F8

236

P00451
MMARRDPKSWAKRLV

FAM90A17

1

P0DV74
DRESPSVKRMRMDAW

MEF2A

491

Q02078
MMARRDPKSWAKRLV

FAM90A16

1

P0DV73
MMARRDPKSWAKRLV

FAM90A19

1

P0DV76
MMARRDPKSWAKRLV

FAM90A8

1

A6NJQ4
FRTLNMDMFTWEPRK

EDIL3

341

O43854
MDMFTWEPRKARLDK

EDIL3

346

O43854
PIFMRKDTKMSFQWR

DPCD

91

Q9BVM2
QSADFMPRWQMLRVL

COQ8B

181

Q96D53
MMARRDPTSWAKRLV

FAM90A20P

1

A6NIJ5
MMARRDPTSWAKRLV

FAM90A5P

1

A8MXJ8
MMARRDPTSWAKRLV

FAM90A24P

1

P0C7X0
RPMNAFMVWSKIERR

SOX11

51

P35716
SRIRRPMNAFMVWAK

SOX17

66

Q9H6I2
PMNAFMVWAKDERKR

SOX17

71

Q9H6I2
SESRIRRPMNAFMVW

SOX7

41

Q9BT81
RRPMNAFMVWAKDER

SOX7

46

Q9BT81
RPMNAFMVWSQIERR

SOX4

61

Q06945
QDRVKRPMNAFMVWS

SOX3

136

P41225
MLRQLSDMRSLWKAN

SLC26A6

456

Q9BXS9
EMLMRWNNLLRKRNF

SERPINA4

296

P29622
MMARRDPKSWAKRLV

FAM90A12P

1

A8MX19
PRWMRVRRSSECMKD

GANAB

811

Q14697
MMARRDPKSWAKRLV

FAM90A9

1

A6NNJ1
MMARRDPTSWAKRLV

FAM90A13P

1

P0C7W8
QSEMKRWMTSLAPNR

NGEF

586

Q8N5V2
MLMQFAEIGRLWRKD

SLC26A3

451

P40879
SLGTRATDMPWKMRR

CDC42BPA

856

Q5VT25
ATDMPWKMRRFAKLD

CDC42BPA

861

Q5VT25
MMARRDPTSWAKRLV

FAM90A15P

1

P0C7V4
RDMVGWPRKNMVREL

CNKSR1

256

Q969H4
RELPSLAKNWVMRML

GTF2H4

46

Q92759
RPMNAFMVWAKDERR

SOX13

426

Q9UN79
NMRWDFSFAIKTRML

nan

106

Q6ZUT4
RKFRDLPKMWSISRM

SLC26A2

496

P50443
KLRSAPRAFAWMMGD

VPS18

276

Q9P253
IPKLMSNMRPQDSWR

XRN2

856

Q9H0D6
WMIRNRRKYAMISSP

PIEZO2

531

Q9H5I5
MRRFEALKLMVQAWP

PRAMEF10

46

O60809
RMWQSMCPLRQFRKL

SNRNP200

1121

O75643
RAPRLWKVRAMMIFN

TMEM253

86

P0C7T8
DESRIRRPMNAFMVW

SOX18

81

P35713
RRPMNAFMVWAKDER

SOX18

86

P35713
MEWRRSYGRAPKMIH

TRAPPC10

46

P48553
MMARRDPKSWAKRLV

FAM90A18

1

P0DV75
DRAGARASWMPMFQR

HAMP

41

P81172