Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein antigen binding

SIRPB1 SIRPG

1.51e-0416232GO:1990405
GeneOntologyMolecularFunctionprotein binding involved in heterotypic cell-cell adhesion

SIRPB1 SIRPG

1.92e-0418232GO:0086080
GeneOntologyMolecularFunctionSH3 domain binding

SIRPB1 SOS1 SIRPG

5.73e-04143233GO:0017124
GeneOntologyMolecularFunctionprotein tyrosine kinase binding

SIRPB1 SOCS5 SIRPG

6.46e-04149233GO:1990782
GeneOntologyMolecularFunctionepidermal growth factor receptor binding

SOCS5 SOS1

1.01e-0341232GO:0005154
GeneOntologyMolecularFunctioncell-cell adhesion mediator activity

SIRPB1 SIRPG

2.23e-0361232GO:0098632
GeneOntologyMolecularFunctionprotein phosphorylated amino acid binding

SIRPB1 SIRPG

2.84e-0369232GO:0045309
GeneOntologyMolecularFunctioncell adhesion mediator activity

SIRPB1 SIRPG

3.43e-0376232GO:0098631
GeneOntologyMolecularFunctionphosphoprotein binding

SIRPB1 SIRPG

7.95e-03117232GO:0051219
GeneOntologyBiologicalProcessnegative regulation of I-kappaB phosphorylation

SIRPB1 SIRPG

7.13e-064232GO:1903720
GeneOntologyBiologicalProcessnegative regulation of chemokine production

SIRPB1 SOCS5 SIRPG

9.96e-0638233GO:0032682
GeneOntologyBiologicalProcessnegative regulation of macrophage inflammatory protein 1 alpha production

SIRPB1 SIRPG

1.19e-055232GO:0071641
GeneOntologyBiologicalProcessnegative regulation of type I interferon production

TRIM27 SIRPB1 SIRPG

2.89e-0554233GO:0032480
GeneOntologyBiologicalProcessregulation of macrophage inflammatory protein 1 alpha production

SIRPB1 SIRPG

3.32e-058232GO:0071640
GeneOntologyBiologicalProcessnegative regulation of chemokine (C-C motif) ligand 5 production

SIRPB1 SIRPG

4.26e-059232GO:0071650
GeneOntologyBiologicalProcessmacrophage inflammatory protein-1 alpha production

SIRPB1 SIRPG

4.26e-059232GO:0071608
GeneOntologyBiologicalProcessnegative regulation of protein phosphorylation

PWP1 TRIM27 SIRPB1 SOCS5 SIRPG

4.97e-05375235GO:0001933
GeneOntologyBiologicalProcessregulation of I-kappaB phosphorylation

SIRPB1 SIRPG

5.32e-0510232GO:1903719
GeneOntologyBiologicalProcessnegative regulation of phosphorylation

PWP1 TRIM27 SIRPB1 SOCS5 SIRPG

6.83e-05401235GO:0042326
GeneOntologyBiologicalProcesscellular response to interleukin-12

SIRPB1 SIRPG

9.21e-0513232GO:0071349
GeneOntologyBiologicalProcessmonocyte extravasation

SIRPB1 SIRPG

9.21e-0513232GO:0035696
GeneOntologyBiologicalProcessnegative regulation of interleukin-6 production

SIRPB1 SOCS5 SIRPG

9.41e-0580233GO:0032715
GeneOntologyBiologicalProcessregulation of chemokine (C-C motif) ligand 5 production

SIRPB1 SIRPG

1.24e-0415232GO:0071649
GeneOntologyBiologicalProcessnegative regulation of tumor necrosis factor production

TRIM27 SIRPB1 SIRPG

1.38e-0491233GO:0032720
GeneOntologyBiologicalProcesschemokine (C-C motif) ligand 5 production

SIRPB1 SIRPG

1.41e-0416232GO:0071609
GeneOntologyBiologicalProcessresponse to interleukin-12

SIRPB1 SIRPG

1.41e-0416232GO:0070671
GeneOntologyBiologicalProcessnegative regulation of tumor necrosis factor superfamily cytokine production

TRIM27 SIRPB1 SIRPG

1.47e-0493233GO:1903556
GeneOntologyBiologicalProcessnegative regulation of phosphate metabolic process

PWP1 TRIM27 SIRPB1 SOCS5 SIRPG

1.56e-04478235GO:0045936
GeneOntologyBiologicalProcessnegative regulation of phosphorus metabolic process

PWP1 TRIM27 SIRPB1 SOCS5 SIRPG

1.59e-04480235GO:0010563
GeneOntologyBiologicalProcessnegative regulation of protein modification process

PWP1 TRIM27 SIRPB1 SOCS5 SIRPG

2.15e-04512235GO:0031400
GeneOntologyBiologicalProcessnegative regulation of interferon-beta production

SIRPB1 SIRPG

2.23e-0420232GO:0032688
GeneOntologyBiologicalProcessI-kappaB phosphorylation

SIRPB1 SIRPG

2.71e-0422232GO:0007252
GeneOntologyBiologicalProcessnegative regulation of nitric oxide metabolic process

SIRPB1 SIRPG

3.51e-0425232GO:1904406
GeneOntologyBiologicalProcessnegative regulation of nitric oxide biosynthetic process

SIRPB1 SIRPG

3.51e-0425232GO:0045019
GeneOntologyBiologicalProcessregulation of chemokine production

SIRPB1 SOCS5 SIRPG

3.52e-04125233GO:0032642
GeneOntologyBiologicalProcesschemokine production

SIRPB1 SOCS5 SIRPG

4.41e-04135233GO:0032602
GeneOntologyBiologicalProcessregulation of type I interferon production

TRIM27 SIRPB1 SIRPG

5.01e-04141233GO:0032479
GeneOntologyBiologicalProcesstype I interferon production

TRIM27 SIRPB1 SIRPG

5.44e-04145233GO:0032606
GeneOntologyBiologicalProcessnegative regulation of phagocytosis

SIRPB1 SIRPG

6.15e-0433232GO:0050765
GeneOntologyBiologicalProcessregulation of type II interferon production

TRIM27 SIRPB1 SIRPG

6.60e-04155233GO:0032649
GeneOntologyBiologicalProcesstype II interferon production

TRIM27 SIRPB1 SIRPG

8.48e-04169233GO:0032609
GeneOntologyBiologicalProcessnegative regulation of multicellular organismal process

TRIM27 LPIN1 F11 CASZ1 SIRPB1 SOCS5 SIRPG

8.79e-041488237GO:0051241
GeneOntologyBiologicalProcessphagocytosis, recognition

SIRPB1 SIRPG

9.97e-0442232GO:0006910
GeneOntologyBiologicalProcessnegative regulation of cytokine production involved in inflammatory response

SIRPB1 SIRPG

1.04e-0343232GO:1900016
GeneOntologyBiologicalProcessnegative regulation of JNK cascade

SIRPB1 SIRPG

1.04e-0343232GO:0046329
GeneOntologyBiologicalProcesshematopoietic progenitor cell differentiation

SIRPB1 SOS1 SIRPG

1.32e-03197233GO:0002244
GeneOntologyBiologicalProcessnegative regulation of cytokine production

TRIM27 SIRPB1 SOCS5 SIRPG

1.36e-03444234GO:0001818
GeneOntologyBiologicalProcessregulation of T cell activation

SIRPB1 SOCS5 SOS1 SIRPG

1.52e-03458234GO:0050863
GeneOntologyBiologicalProcessregulation of interleukin-6 production

SIRPB1 SOCS5 SIRPG

1.63e-03212233GO:0032675
GeneOntologyBiologicalProcessNADP metabolic process

ACACB FDXR

1.77e-0356232GO:0006739
GeneOntologyBiologicalProcessinterleukin-6 production

SIRPB1 SOCS5 SIRPG

1.83e-03221233GO:0032635
GeneOntologyBiologicalProcessregulation of tumor necrosis factor production

TRIM27 SIRPB1 SIRPG

2.06e-03230233GO:0032680
GeneOntologyBiologicalProcessregulation of tumor necrosis factor superfamily cytokine production

TRIM27 SIRPB1 SIRPG

2.21e-03236233GO:1903555
GeneOntologyBiologicalProcessnegative regulation of response to external stimulus

F11 SIRPB1 SOCS5 SIRPG

2.24e-03509234GO:0032102
GeneOntologyBiologicalProcesstumor necrosis factor production

TRIM27 SIRPB1 SIRPG

2.24e-03237233GO:0032640
GeneOntologyBiologicalProcessnegative regulation of inflammatory response

SIRPB1 SOCS5 SIRPG

2.29e-03239233GO:0050728
GeneOntologyBiologicalProcesstumor necrosis factor superfamily cytokine production

TRIM27 SIRPB1 SIRPG

2.40e-03243233GO:0071706
GeneOntologyBiologicalProcessresponse to reactive oxygen species

SESN3 SIRPB1 SIRPG

2.49e-03246233GO:0000302
GeneOntologyBiologicalProcessphagocytosis, engulfment

SIRPB1 SIRPG

2.67e-0369232GO:0006911
GeneOntologyBiologicalProcessinterferon-beta production

SIRPB1 SIRPG

2.98e-0373232GO:0032608
GeneOntologyBiologicalProcessregulation of interferon-beta production

SIRPB1 SIRPG

2.98e-0373232GO:0032648
GeneOntologyBiologicalProcesscellular response to insulin stimulus

SESN3 LPIN1 SOS1

3.27e-03271233GO:0032869
GeneOntologyBiologicalProcessplasma membrane invagination

SIRPB1 SIRPG

3.39e-0378232GO:0099024
GeneOntologyBiologicalProcesscellular response to cytokine stimulus

IL17RE SIRPB1 SOCS5 SOS1 SIRPG

3.72e-03967235GO:0071345
GeneOntologyBiologicalProcesscellular response to hydrogen peroxide

SIRPB1 SIRPG

3.74e-0382232GO:0070301
GeneOntologyBiologicalProcesspositive regulation of T cell activation

SIRPB1 SOCS5 SIRPG

3.96e-03290233GO:0050870
GeneOntologyBiologicalProcesscellular extravasation

SIRPB1 SIRPG

4.01e-0385232GO:0045123
GeneOntologyBiologicalProcessregulation of cytokine production involved in inflammatory response

SIRPB1 SIRPG

4.01e-0385232GO:1900015
GeneOntologyBiologicalProcesscellular response to interleukin-1

SIRPB1 SIRPG

4.01e-0385232GO:0071347
GeneOntologyBiologicalProcessregulation of epidermal growth factor receptor signaling pathway

SOCS5 SOS1

4.11e-0386232GO:0042058
GeneOntologyBiologicalProcessmembrane invagination

SIRPB1 SIRPG

4.20e-0387232GO:0010324
GeneOntologyCellularComponentmitochondrial outer membrane

ACACB LPIN1 NEU4

2.26e-03241233GO:0005741
GeneOntologyCellularComponentorganelle outer membrane

ACACB LPIN1 NEU4

3.42e-03279233GO:0031968
GeneOntologyCellularComponentouter membrane

ACACB LPIN1 NEU4

3.49e-03281233GO:0019867
MousePhenoincreased megakaryocyte cell number

SIRPB1 SOS1 SIRPG

3.42e-0545203MP:0008254
DomainC1-set

SIRPB1 SIRPG

2.00e-0354232PF07654
DomainIGc1

SIRPB1 SIRPG

2.15e-0356232SM00407
DomainIg_C1-set

SIRPB1 SIRPG

2.30e-0358232IPR003597
DomainIGv

SIRPB1 SIRPG

3.81e-0375232SM00406
PathwayREACTOME_SIGNAL_REGULATORY_PROTEIN_FAMILY_INTERACTIONS

SIRPB1 SIRPG

9.55e-0514152MM15011
PathwayREACTOME_SIGNAL_REGULATORY_PROTEIN_FAMILY_INTERACTIONS

SIRPB1 SIRPG

1.26e-0416152M925
Pubmed

SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.

SIRPB1 SIRPG

1.37e-06324236202053
Pubmed

Requirement of SIRPα for protective immunity against Leishmania major.

SIRPB1 SIRPG

1.37e-06324220854790
Pubmed

Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance.

SIRPB1 SIRPG

1.37e-06324233074246
Pubmed

Central nervous system antigen P84 can serve as a substrate for neurite outgrowth.

SIRPB1 SIRPG

1.37e-0632422303162
Pubmed

SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages.

SIRPB1 SIRPG

1.37e-06324216141346
Pubmed

Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes.

SIRPB1 SIRPG

1.37e-06324215034021
Pubmed

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury.

SIRPB1 SIRPG

1.37e-06324231883525
Pubmed

Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression.

SIRPB1 SIRPG

1.37e-06324223504854
Pubmed

Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice.

SIRPB1 SIRPG

1.37e-06324217617577
Pubmed

Resistance to collagen-induced arthritis in SHPS-1 mutant mice.

SIRPB1 SIRPG

1.37e-06324218455510
Pubmed

Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling.

SIRPB1 SIRPG

1.37e-06324226057870
Pubmed

Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen.

SIRPB1 SIRPG

1.37e-06324226222253
Pubmed

Essential roles of SHPS-1 in induction of contact hypersensitivity of skin.

SIRPB1 SIRPG

1.37e-06324218809435
Pubmed

SIRPα signaling regulates podocyte structure and function.

SIRPB1 SIRPG

1.37e-06324223842779
Pubmed

Essential roles of SIRPα in homeostatic regulation of skin dendritic cells.

SIRPB1 SIRPG

1.37e-06324220955735
Pubmed

A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9.

SIRPB1 SIRPG

1.37e-06324217825046
Pubmed

Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function.

SIRPB1 SIRPG

1.37e-06324219223164
Pubmed

SIRPα deficiency accelerates the pathologic process in models of Parkinson disease.

SIRPB1 SIRPG

1.37e-06324231322787
Pubmed

Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages.

SIRPB1 SIRPG

1.37e-06324218233962
Pubmed

BIT, an immune antigen receptor-like molecule in the brain.

SIRPB1 SIRPG

1.37e-0632429271230
Pubmed

Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis.

SIRPB1 SIRPG

1.37e-06324235634325
Pubmed

Gene structure of mouse BIT/SHPS-1.

SIRPB1 SIRPG

1.37e-06324210585853
Pubmed

Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury.

SIRPB1 SIRPG

1.37e-06324223559001
Pubmed

Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.

SIRPB1 SIRPG

1.37e-06324212167615
Pubmed

Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk.

SIRPB1 SIRPG

1.37e-06324231507080
Pubmed

The Rho kinase pathway regulates the migration of dendritic cells through SIRP-α.

SIRPB1 SIRPG

1.37e-06324222391241
Pubmed

The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family.

SIRPB1 SIRPG

1.37e-0632429348339
Pubmed

Targeting SIRP-α protects from type 2-driven allergic airway inflammation.

SIRPB1 SIRPG

1.37e-06324221108471
Pubmed

Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages.

SIRPB1 SIRPG

1.37e-06324216920950
Pubmed

Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the induction of Langerhans cell maturation.

SIRPB1 SIRPG

1.37e-06324217109464
Pubmed

SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress.

SIRPB1 SIRPG

1.37e-06324222671569
Pubmed

Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation.

SIRPB1 SIRPG

1.37e-06324223504624
Pubmed

Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPα inhibitory signaling in mice.

SIRPB1 SIRPG

1.37e-06324223472187
Pubmed

Involvement of signal regulatory protein α, a negative regulator of Toll-like receptor signaling, in impairing the MyD88-independent pathway and intracellular killing of Burkholderia pseudomallei-infected mouse macrophages.

SIRPB1 SIRPG

1.37e-06324222988019
Pubmed

Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain.

SIRPB1 SIRPG

1.37e-06324222468987
Pubmed

Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.

SIRPB1 SIRPG

1.37e-06324235511221
Pubmed

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.

SIRPB1 SIRPG

1.37e-06324234917090
Pubmed

Effect of Serum Deprivation Stress on Signal Induction Regulatory Protein-Alpha (SIRP-Alpha)-Mediated Erythrophagocytosis by Macrophages.

SIRPB1 SIRPG

1.37e-06324230894504
Pubmed

Regulation by Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of alpha-galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells.

SIRPB1 SIRPG

1.37e-06324217475843
Pubmed

Inhibitory regulation of osteoclast bone resorption by signal regulatory protein alpha.

SIRPB1 SIRPG

1.37e-06324219667119
Pubmed

Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes.

SIRPB1 SIRPG

1.37e-06324218635660
Pubmed

SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors.

SIRPB1 SIRPG

1.37e-06324228669759
Pubmed

Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation.

SIRPB1 SIRPG

1.37e-06324229914984
Pubmed

Focal cerebral ischemia upregulates SHP-1 in reactive astrocytes in juvenile mice.

SIRPB1 SIRPG

1.37e-06324212742627
Pubmed

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103(+) CD11b(+) DCs in the intestinal lamina propria.

SIRPB1 SIRPG

1.37e-06324225236797
Pubmed

SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility.

SIRPB1 SIRPG

1.37e-06324211118207
Pubmed

Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs.

SIRPB1 SIRPG

1.37e-06324225818708
Pubmed

SIRPα controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox).

SIRPB1 SIRPG

1.37e-06324223022485
Pubmed

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

SIRPB1 SIRPG

1.37e-06324229158380
Pubmed

Deficiency in SIRP-α cytoplasmic recruitment confers protection from acute kidney injury.

SIRPB1 SIRPG

1.37e-06324231370677
Pubmed

Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.

SIRPB1 SIRPG

1.37e-06324234050181
Pubmed

Lack of non-hematopoietic SIRPα signaling disturbs the splenic marginal zone architecture resulting in accumulation and displacement of marginal zone B cells.

SIRPB1 SIRPG

1.37e-06324225817792
Pubmed

Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.

SIRPB1 SIRPG

1.37e-06324215123722
Pubmed

A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression.

SIRPB1 SIRPG

1.37e-06324230770827
Pubmed

Signal regulatory protein α protects podocytes through promoting autophagic activity.

SIRPB1 SIRPG

1.37e-06324230888336
Pubmed

Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.

SIRPB1 SIRPG

1.37e-06324212134038
Pubmed

Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.

SIRPB1 SIRPG

1.37e-06324238758648
Pubmed

SIRPα+ dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes.

SIRPB1 SIRPG

1.37e-06324231099900
Pubmed

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration.

SIRPB1 SIRPG

1.37e-06324233795678
Pubmed

HSF1 promotes the viability of islet β-cells via upregulating SIRPα expression.

SIRPB1 SIRPG

2.74e-06424232141563
Pubmed

CD47 restricts antiviral function of alveolar macrophages during influenza virus infection.

SIRPB1 SIRPG

2.74e-06424236437873
Pubmed

Enhanced phagocytosis of CD47-deficient red blood cells by splenic macrophages requires SHPS-1.

SIRPB1 SIRPG

2.74e-06424216580635
Pubmed

CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.

SIRPB1 SIRPG

2.74e-06424222042861
Pubmed

SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.

SIRPB1 SIRPG

2.74e-06424235722884
Pubmed

Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling.

SIRPB1 SIRPG

2.74e-06424216697668
Pubmed

SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.

SIRPB1 SIRPG

2.74e-06424235413056
Pubmed

Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B.

SIRPB1 SIRPG

2.74e-06424212446684
Pubmed

Synapse maturation by activity-dependent ectodomain shedding of SIRPα.

SIRPB1 SIRPG

2.74e-06424224036914
Pubmed

An essential role for the association of CD47 to SHPS-1 in skeletal remodeling.

SIRPB1 SIRPG

2.74e-06424221638321
Pubmed

The absence of CD47 promotes nerve fiber growth from cultured ventral mesencephalic dopamine neurons.

SIRPB1 SIRPG

2.74e-06424223049778
Pubmed

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.

SIRPB1 SIRPG

2.74e-06424222976304
Pubmed

Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues.

SIRPB1 SIRPG

2.74e-06424220682853
Pubmed

Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling.

SIRPB1 SIRPG

2.74e-06424223990469
Pubmed

Signal regulatory protein-α protects against cardiac hypertrophy via the disruption of toll-like receptor 4 signaling.

SIRPB1 SIRPG

2.74e-06424224101669
Pubmed

Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.

SIRPB1 SIRPG

2.74e-06424234097709
Pubmed

Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease.

SIRPB1 SIRPG

2.74e-06424223515050
Pubmed

TLR5 mediates CD172α(+) intestinal lamina propria dendritic cell induction of Th17 cells.

SIRPB1 SIRPG

2.74e-06424226907705
Pubmed

Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.

SIRPB1 SIRPG

2.74e-06424238245585
Pubmed

CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.

SIRPB1 SIRPG

2.74e-06424232768386
Pubmed

Dual regulation of SIRPalpha phosphorylation by integrins and CD47.

SIRPB1 SIRPG

2.74e-06424217584740
Pubmed

Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model.

SIRPB1 SIRPG

2.74e-06424237095207
Pubmed

Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels.

SIRPB1 SIRPG

2.74e-06424220299253
Pubmed

Protein tyrosine phosphatase Shp2 positively regulates cold stress-induced tyrosine phosphorylation of SIRPα in neurons.

SIRPB1 SIRPG

2.74e-06424234237430
Pubmed

Down-regulation of platelet surface CD47 expression in Escherichia coli O157:H7 infection-induced thrombocytopenia.

SIRPB1 SIRPG

2.74e-06424219771158
Pubmed

Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ.

SIRPB1 SIRPG

2.74e-06424233028619
Pubmed

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.

SIRPB1 SIRPG

2.74e-06424230308165
Pubmed

Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPα Facilitate Apoptotic Cell Clearance by Macrophages.

SIRPB1 SIRPG

2.74e-06424226085683
Pubmed

High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages.

SIRPB1 SIRPG

2.74e-0642429712903
Pubmed

The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.

SIRPB1 SIRPG

2.74e-06424224269920
Pubmed

Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling.

SIRPB1 SIRPG

2.74e-06424228545141
Pubmed

Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.

SIRPB1 SIRPG

2.74e-0642428810330
Pubmed

Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses.

SIRPB1 SIRPG

2.74e-06424210477552
Pubmed

Target cell CD47 regulates macrophage activation and erythrophagocytosis.

SIRPB1 SIRPG

2.74e-06424216564725
Pubmed

BIT (Bit) maps to mouse chromosome 2.

SIRPB1 SIRPG

2.74e-0642429073522
Pubmed

Signal regulatory protein alpha1 is involved in the inhibitory effect of glucocorticoid receptor on the proliferation of murine macrophage RAW264.7 cell and mouse peritoneal macrophage.

SIRPB1 SIRPG

2.74e-06424218728125
Pubmed

'Clustering' SIRPα into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47.

SIRPB1 SIRPG

2.74e-06424224143245
Pubmed

The SIRPα-CD47 immune checkpoint in NK cells.

SIRPB1 SIRPG

2.74e-06424233416832
Pubmed

Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr.

SIRPB1 SIRPG

2.74e-06424210662797
Pubmed

Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.

SIRPB1 SIRPG

2.74e-06424232294445
Pubmed

Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration.

SIRPB1 SIRPG

2.74e-06424234197341
InteractionSIRPA interactions

TRIM27 SIRPB1 SOS1 SIRPG

5.62e-06100244int:SIRPA
InteractionPLEKHN1 interactions

TRIM27 BRWD3 USP54

3.74e-0555243int:PLEKHN1
Cytoband2p21

SOCS5 SOS1

4.70e-04612422p21
Cytoband20p13

SIRPB1 SIRPG

1.31e-0310224220p13
CytobandEnsembl 112 genes in cytogenetic band chr20p13

SIRPB1 SIRPG

1.89e-03123242chr20p13
CytobandEnsembl 112 genes in cytogenetic band chr3q13

SLC35A5 BBX

5.94e-03221242chr3q13
GeneFamilyCD molecules|V-set domain containing|C1-set domain containing|Signal regulatory proteins

SIRPB1 SIRPG

8.31e-065172747
GeneFamilyC1-set domain containing

SIRPB1 SIRPG

7.01e-0442172591
GeneFamilyAdenosine receptors|V-set domain containing

SIRPB1 SIRPG

1.01e-02163172590
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IL17RE CASZ1 BRWD3 SIRPB1 SOCS5

1.36e-08146245cffa91d76606f74553d81150adbb23b003746316
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

IL17RE CASZ1 BRWD3 SIRPB1 SOCS5

1.72e-08153245e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCellnormal_Pleural_Fluid-T/NK_cells-CD4+_Th|normal_Pleural_Fluid / Location, Cell class and cell subclass

KLHL24 FDXR SIRPG

8.30e-05159243ebd840ac2b07e62086ee7b5bb01c21804a0fdc7b
ToppCellTCGA-Lung-Solid_Tissue_Normal|TCGA-Lung / Sample_Type by Project: Shred V9

F11 SIRPB1 PTPN21

9.43e-05166243a8ebdd3cb7f59b3feeaacda45ce6d40d10db556f
ToppCellTCGA-Lung-Solid_Tissue_Normal-Lung|TCGA-Lung / Sample_Type by Project: Shred V9

F11 SIRPB1 PTPN21

9.43e-05166243c64971c27cb445dffc5a636d4b6a60261b93a2db
ToppCellTCGA-Lung-Solid_Tissue_Normal-Lung-Lung_normal_tissue-6|TCGA-Lung / Sample_Type by Project: Shred V9

F11 SIRPB1 PTPN21

9.43e-05166243188f2575511f418216874aed9118aa6f165252cb
ToppCellTCGA-Lung-Solid_Tissue_Normal-Lung-Lung_normal_tissue|TCGA-Lung / Sample_Type by Project: Shred V9

F11 SIRPB1 PTPN21

9.43e-051662432f3072a7af048f184d33065fdd36153fd563155a
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

NEU4 SLC35A5 PTPN21

9.60e-05167243c0c944eae0514dc8e00d0c2892a0792e157695ec
ToppCellT_cells-TFH-like_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SESN3 SIRPB1 SIRPG

1.16e-04178243e2ae43e5ec31de6197f2cbd6089f944adbf0a163
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

LAMB3 CASZ1 USP54

1.18e-04179243a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellAT1_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

LAMB3 IL17RE PTPN21

1.20e-041802432d52cb5f77dde0e3dccac1333d4ec67ec680fcb2
ToppCellAT1-AT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

IL17RE USP54 PTPN21

1.26e-041832436821dca076318115d360ff426eb1218cfe104063
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

KLHL24 BRWD3 SOS1

1.32e-0418624303db813598b67b1e08f759758a1c2023396921fa
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

ACACB KLHL24 CASZ1

1.34e-0418724378cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

ACACB KLHL24 CASZ1

1.38e-041892435e80c47f63980904c4c1ff02c201b67b456a0974
ToppCelldroplet-Trachea-nan-3m-Epithelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB3 IL17RE CASZ1

1.41e-04190243434de72dde09644efbddcaa643a4a3eaf5f643bf
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMB3 IL17RE CASZ1

1.41e-0419024301e7747547ea1f3049a11a1717565ba71dd52bdc
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACB IL17RE SOCS5

1.41e-041902435cea8298c8336c136ba009630c9e48d4bc832cb2
ToppCelldroplet-Trachea-nan-3m-Epithelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB3 IL17RE CASZ1

1.41e-04190243e647f9a2dcf7f2dffef53c45bbe171416518fd59
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

ACACB KLHL24 CASZ1

1.41e-04190243fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCelldroplet-Trachea-3m-Epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMB3 IL17RE CASZ1

1.41e-041902430114cf48612d78c3ada4d8a05850501fef6892c5
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACB IL17RE SOCS5

1.41e-04190243c247562df3e1aa3173c9f01a74d5831f0764a1b2
ToppCell(09)_Interm._secr.>cil.-(0)_Reference|(09)_Interm._secr.>cil. / shred by cell type by condition

LPIN1 FDXR SIRPG

1.43e-04191243e63432718d62d39165ba8a66e14bb38c93907ffe
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACACB F11 CASZ1

1.43e-04191243963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCellE15.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SESN3 LAMB3 IL17RE

1.43e-04191243402c341b00f98e8215458766b3c219fff8dcb447
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACB IL17RE SOCS5

1.43e-04191243e1ec165ba6578cefd88895e7e183190e79f733a4
ToppCell15-Airway-Epithelial-Secretory_progenitor|Airway / Age, Tissue, Lineage and Cell class

LAMB3 KLHL24 USP54

1.43e-041912439359d8c6b00f8977848986baf3c950157adf4c9a
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACB IL17RE SOCS5

1.43e-04191243297bc79adc5fef211497819b4861b52cd26ac754
ToppCellE15.5-Epithelial-alveolar_epithelial_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SESN3 LAMB3 IL17RE

1.45e-04192243567f4355a01aae1f2eafc16fe86d1538a62030ab
ToppCell(10)_Ciliated-(0)_Reference|(10)_Ciliated / shred by cell type by condition

LPIN1 FDXR SIRPG

1.49e-04194243f9d5bf6baddbd88947e6a740805962109649ed3b
ToppCell(7)_Epithelial-I_(AT1)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

LAMB3 IL17RE PTPN21

1.54e-04196243150554fa06868d29b0608189862eef6505ba757f
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMB3 IL17RE PTPN21

1.54e-041962436856317cd0cdcb88fe54b4ae905d91e13495b1c4
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT1-AT1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMB3 IL17RE PTPN21

1.54e-041962436731fef8c148b6681d6ed38afdf23c8213e0bbbe
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMB3 IL17RE PTPN21

1.56e-04197243e344455e62b3fe94bb242dc0db58d19a1d3878c7
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMB3 IL17RE PTPN21

1.56e-04197243c9c968e223e7814cd8d22975d849a31b7e0af7aa
ToppCellControl_saline-Epithelial_alveolar-AT_2-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

LAMB3 IL17RE USP54

1.56e-0419724344a59dfb889577b3160a5b13ada1276771a00241
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LAMB3 IL17RE USP54

1.56e-041972433d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMB3 IL17RE PTPN21

1.56e-04197243734b8db5bb4917c9ce92ed342fe6c22b64b0d3c5
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_late|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

LAMB3 IL17RE USP54

1.59e-041982431851b7f4198b42c21c934e2fbda39dbd65e2625c
ToppCellControl_saline-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor|Control_saline / Treatment groups by lineage, cell group, cell type

LAMB3 IL17RE USP54

1.59e-04198243030ef63e2fc5b3d601c1a48462d797aa19ee7ff5
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

LAMB3 IL17RE USP54

1.61e-041992431c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCellParenchymal-10x5prime-Epithelial-Epi_alveolar-AT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAMB3 IL17RE PTPN21

1.61e-04199243aca81a879ef9c196bd1885eff4c63ffe6c9682b7
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

LAMB3 IL17RE USP54

1.63e-04200243ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellproximal-Epithelial-Alveolar_Epithelial_Type_1|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LAMB3 IL17RE PTPN21

1.63e-04200243c1345893e6947ccf9b41282d0e4428dbfb8bcc27
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-OPC_related|10w / Sample Type, Dataset, Time_group, and Cell type.

SESN3 CASZ1 BBX

1.63e-042002438f5d98f962ddd8c4658c89ff8a2894de1228562a
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_alveolar-AT1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LAMB3 IL17RE PTPN21

1.63e-042002433d51aebf626dd4656ab4aac8a20d761b8062c42d
ToppCellproximal-Epithelial-Alveolar_Epithelial_Type_1-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LAMB3 IL17RE PTPN21

1.63e-04200243b652bc73adfdeccbdcd74497ab6e2085e5c95e88
ToppCellBiopsy_Control_(H.)-Epithelial-AT1|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

LAMB3 IL17RE PTPN21

1.63e-042002433a9633f5913f12b6865fc777c84f3f3ba795a78d
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

LAMB3 IL17RE USP54

1.63e-04200243eac33be484dc443794e66e473f03e98406c2983e
ToppCellproximal-3-Epithelial-Alveolar_Epithelial_Type_1|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LAMB3 IL17RE PTPN21

1.63e-0420024351f8fc43c069f2c4e75588d28ae6deb5d7ed2c86
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-OPC_related-Oligodendrocyte/OPC|10w / Sample Type, Dataset, Time_group, and Cell type.

SESN3 CASZ1 BBX

1.63e-04200243345f1eac498cc87fd7bf08e7312608b2d6fe1dd7
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / Treatment groups by lineage, cell group, cell type

LAMB3 IL17RE USP54

1.63e-042002432dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-1|TCGA-Breast / Sample_Type by Project: Shred V9

CASZ1 NUDT6

1.64e-03112242518b7ab98b988b23f3d0f0e1f4fe90a7068f9d87
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-dn_T-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SESN3 SIRPG

2.06e-0312624213333101d52300fc45fb9f7ca05cace502c72186
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-dn_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SESN3 SIRPG

2.06e-031262425d13a2a37efd2645d2859f02e5abb36864896bbe
ToppCellControl-Lymphoid_T/NK-dn_T|Control / Disease group, lineage and cell class

SESN3 SIRPG

2.09e-0312724258f47cb079c596a9119d8bf158c1681b28360ac3
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-dn_T-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SESN3 SIRPG

2.09e-03127242d4c6e65a4e4c2c9422bea11b9f78e4beabf04961
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-dn_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SESN3 SIRPG

2.09e-031272424ccda89414f18313269be2f5a1542314b1b10572
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMB3 USP54

2.19e-031302426434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Spindle_Cell-2|TCGA-Uvea / Sample_Type by Project: Shred V9

KLHL24 BBX

2.40e-03136242b460669c13ed43ff3885acd38ce18f75d693738d
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SESN3 BRWD3

2.43e-03137242e9b88ad86b75454a8292a94879c5b665adc42744
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LAMB3 FDXR

2.47e-031382422e46d546ad962aa0fde5b1c18c2a5370a4424e9f
ToppCellfacs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL17RE NEU4

2.57e-031412424aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCellfacs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL17RE NEU4

2.57e-03141242e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCellPBMC-Mild-cDC_7|Mild / Compartment, Disease Groups and Clusters

LPIN1 NEU4

2.61e-0314224258f66f35646f281e64d634e6c26adbd1d4e6c830
ToppCellControl-Epithelial_alveolar-AT_1-AT2_Progenitor|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMB3 USP54

2.61e-0314224294e277f038f4006d99ff50222b0f5cf89bc3d46d
ToppCellfacs-Heart-Unknown-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL17RE NEU4

2.61e-03142242759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCellPND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature_2|PND01-03-samps / Age Group, Lineage, Cell class and subclass

TRIM27 USP54

2.64e-03143242abe6ec0f6956b87f394d537926eb2427fcfad93f
ToppCellIIH-CD8-proli_CD4|IIH / Condition, Cell_class and T cell subcluster

IL17RE USP54

2.75e-031462427fa6e35def3f7cffbee1e1c2f10b523bab678e14
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

NEU4 NUDT6

2.79e-03147242e99197e3c2e9d63153cc55ae62b30b8363c2267e
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

BRWD3 SOS1

2.90e-03150242744050a1b665c6989f37141348af3df7579a73c9
ToppCellfacs-Marrow-Granulocytes-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LPIN1 F11

2.90e-03150242a3a4710820a244116a26204f40e7113a1e7236c5
ToppCellfacs-Marrow-Granulocytes-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LPIN1 F11

2.90e-0315024213dcd519dacf08d5852aa3e029e0a3308de07321
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PTPN21 SIRPG

2.98e-03152242eb7ff36792c3c54ac88cfe976f84016b70b1a1d7
ToppCellBasal_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

SESN3 LAMB3

2.98e-0315224272499e4d2b374ef5f1621c89d94727ecf4bd4d5d
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PTPN21 SIRPG

2.98e-031522426d02b50e9e9ecf820f84a79e46d153a4840a1cfe
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT2_Progenitor|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMB3 USP54

3.02e-03153242e7a074ea8232bacf924be78a244a8507c7e1ebc8
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SESN3 SIRPG

3.02e-031532427518187a5fbf6c0881182dc79bd37c2d49f92b2e
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SESN3 SIRPG

3.02e-0315324293d36723f01c2df39feebf20f3eba5b4fb4cdf59
ToppCellControl-PLT_4|World / Disease Group and Platelet Clusters

KLHL24 CASZ1

3.06e-03154242a2a03c5e6759c45aeeedf1e68ecb5a0112ef9a20
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

USP54 SIRPG

3.10e-03155242335cd798afbaa0a3a3e1dc558a81cfa32da48983
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tregs|GI_small-bowel / Manually curated celltypes from each tissue

SESN3 SIRPG

3.10e-03155242d4ef25965a15eab7679478b9b661e1b4a92f1c59
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Papillary_Adenocarcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

TRIM27 IL17RE

3.10e-0315524257259549d7ad97d9f628b821417be5ddac7dbff7
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

USP54 SIRPG

3.14e-03156242fc8b8aef29d6d1c0f0c1d08280d8aaff8d30535e
ToppCellTCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Testicular_Germ_Cell_Tumor|TCGA-Testes / Sample_Type by Project: Shred V9

LAMB3 IL17RE

3.14e-03156242f9eb18a0f00de211fab36d7d88fcf08276d53dcc
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LPIN1 SIRPG

3.21e-031582421cefb82b9bf79c687a119be568cfc15b14c6e040
ToppCell10x5'-Lung-Lymphocytic_T_CD4-Tregs|Lung / Manually curated celltypes from each tissue

SESN3 SIRPG

3.21e-03158242f433bc189f000efa34e8e09ab32b3fa22bcf64c4
ToppCellCOVID-19_Moderate-MAIT|COVID-19_Moderate / disease group, cell group and cell class

IL17RE SIRPG

3.25e-031592426d08d670c34eb6bb8ad5dad3293b3107c006236d
ToppCellICU-NoSEP-Lymphocyte-T_NK-CD8_TCM|ICU-NoSEP / Disease, Lineage and Cell Type

NEU4 SIRPG

3.29e-03160242a1bf6ed365cbc1ddb57c132a42dbe6485d45f544
ToppCellCOVID-19_Moderate-MAIT|World / disease group, cell group and cell class

IL17RE SIRPG

3.29e-03160242bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IL17RE SIRPG

3.29e-03160242c2b5fadb4bac17fafc08831f6d3f4ff96ada7e70
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PWP1 USP54

3.34e-03161242249c2b97cc25de5053f5048ee354615df49b2081
ToppCell390C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SLC35A5 SOS1

3.38e-03162242fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCellfacs-Lung-Endomucin-24m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUDT6 PTPN21

3.38e-03162242497ae9f86a5e7946d0fde932b35719a382a6b691
ToppCell390C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SLC35A5 SOS1

3.38e-0316224245be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCellfacs-Lung-Endomucin-24m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUDT6 PTPN21

3.38e-031622427b2949eba2b4aea239d96ed82aafab13b07624eb
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SESN3 BRWD3

3.42e-031632424af92b211d12c5b88b65bb746242cd702b545bd0
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

F11 BBX

3.42e-03163242cab65dabeea58141c649e4fec5e0123beb3de1b3
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Adult / Lineage, Cell type, age group and donor

KLHL24 USP54

3.42e-03163242e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SESN3 BRWD3

3.42e-03163242d24774e0aa612322c22fdb3b314aef275fa01d68
Diseasesignal-regulatory protein beta-1 measurement

SIRPB1 SIRPG

1.90e-059222EFO_0802069
Diseasenarcolepsy-cataplexy syndrome

NEU4 SIRPG

8.85e-0459222MONDO_0016158
Diseaseimmature platelet count

SIRPB1 SIRPG

2.82e-03106222EFO_0803544
Diseasewhite matter microstructure measurement

TRIM27 KLHL24 SOS1

2.93e-03390223EFO_0005674
Diseaseimmature platelet fraction

SIRPB1 SIRPG

3.25e-03114222EFO_0009187
Diseaseimmature platelet measurement

SIRPB1 SIRPG

3.53e-03119222EFO_0803541

Protein segments in the cluster

PeptideGeneStartEntry
HKCSHFPDFSYSASS

BBX

401

Q8WY36
CHFADCPFSGTSTHF

CASZ1

1501

Q86V15
PAGSTPSFCHHFSTQ

FDXR

21

P22570
FSPDGNHFACTDSHG

BRWD3

521

Q6RI45
GLHEFADSQFGHCFS

ACACB

691

O00763
FKFSFGNSSHVECPH

IL17RE

341

Q8NFR9
AFFSFFTHCFGHDIP

OR52E6

256

Q96RD3
APAASLGFCFHHAES

NUDT6

106

P53370
SHSSDFPCSDTFSNF

LPIN1

856

Q14693
CRTSPHSFAFYSDDH

NEU4

191

Q8WWR8
AAAHCPFSLSYSFHS

PTPN21

506

Q16825
GHEFFDFSSGSSHAE

KLHL24

36

Q6TFL4
THHPGCLFFTFFSQE

F11

231

P03951
HSETCHFDPAVFAAS

LAMB3

321

Q13751
HRTFSHFSCGSQPAA

CT62

26

P0C5K7
CHTFTFSHATFCGPV

TRIM27

456

P14373
NFSFDAHDPCVFHSS

SOCS5

436

O75159
VCSVFDSDHSSPFHS

SOS1

1101

Q07889
EHTVSFTCESHGFSP

SIRPG

161

Q9P1W8
PEHTVSFTCESHGFS

SIRPB1

161

O00241
NHFSPCHFLASTDDG

PWP1

351

Q13610
HHDAFFSPSNSCLLF

SLC35A5

181

Q9BS91
VSGDTFHSFPHSDFE

SESN3

301

P58005
EFGASSFFHSPASCH

USP54

916

Q70EL1
SFFHSPASCHESHSS

USP54

921

Q70EL1