Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Elevated diastolic blood pressure	AGT STOX1 ADD1	2.23e-05	13	23	3	HP:0005117
HumanPheno	Elevated systolic blood pressure	AGT STOX1 ADD1	2.83e-05	14	23	3	HP:0004421
Domain	Ribosomal_L3	RPL3 RPL3L	5.42e-05	3	80	2	IPR000597
Domain	RIBOSOMAL_L3	RPL3 RPL3L	5.42e-05	3	80	2	PS00474
Domain	Ribosomal_L3	RPL3 RPL3L	5.42e-05	3	80	2	PF00297
Domain	Ribosomal_L3_CS	RPL3 RPL3L	5.42e-05	3	80	2	IPR019926
Domain	Hydantoinase/dihydroPyrase	DPYSL4 CRMP1	2.69e-04	6	80	2	IPR011778
Domain	-	DPYSL4 CRMP1	4.99e-04	8	80	2	2.30.40.10
Domain	Amidohydro_1	DPYSL4 CRMP1	7.97e-04	10	80	2	PF01979
Domain	Metal-dep_hydrolase_composite	DPYSL4 CRMP1	7.97e-04	10	80	2	IPR011059
Domain	Amidohydro-rel	DPYSL4 CRMP1	9.72e-04	11	80	2	IPR006680
Domain	-	SYDE2 UNC13C PLA2G4D NEDD4	3.76e-03	148	80	4	2.60.40.150
Domain	Metal_Hydrolase	DPYSL4 CRMP1	4.70e-03	24	80	2	IPR032466
Pubmed	Combined analysis of polymorphisms in angiotensinogen and adducin genes and their effects on hypertension in a Japanese sample: The Shigaraki Study.	AGT ADD1	5.76e-06	2	84	2	16392768
Pubmed	A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region.	RPL3 RPL3L	5.76e-06	2	84	2	8921388
Pubmed	The influence of the alpha-adducin G460W polymorphism and angiotensinogen M235T polymorphism on antihypertensive medication and blood pressure.	AGT ADD1	5.76e-06	2	84	2	16724011
Pubmed	RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function.	RPL3 RPL3L	5.76e-06	2	84	2	37080962
Pubmed	Both angiotensinogen M235T and alpha-adducin G460W polymorphisms are associated with hypertension in the Japanese population.	AGT ADD1	5.76e-06	2	84	2	17215849
Pubmed	Expression of Muscle-Specific Ribosomal Protein L3-Like Impairs Myotube Growth.	RPL3 RPL3L	5.76e-06	2	84	2	26684695
Pubmed	Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.	RPL3 RPL3L	5.76e-06	2	84	2	36882085
Pubmed	Renal haemodynamics are not related to genotypes in offspring of parents with essential hypertension.	AGT ADD1	1.73e-05	3	84	2	17083073
Pubmed	CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis.	POLR1A NMD3	1.73e-05	3	84	2	23782956
Pubmed	Arterial properties in relation to genetic variation in alpha-adducin and the renin-angiotensin system in a White population.	AGT ADD1	1.73e-05	3	84	2	18800139
Pubmed	YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.	EIF3A EIF2AK2	1.73e-05	3	84	2	35708211
Pubmed	Gene polymorphisms of adducin GLY460TRP, ACE I/D, AND AGT M235T in pediatric hypertension patients.	AGT ADD1	1.73e-05	3	84	2	25262176
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PMS1 WDR11 SIK2 TFIP11 ANKZF1 RPL3 RHOT1 ZXDB CEMIP	2.79e-05	650	84	9	38777146
Pubmed	Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study.	AGT ADD1	3.45e-05	4	84	2	19057513
Pubmed	[Study on the association of predisposing genes with essential hypertension among Kazakhs ethnic group in Xinjiang].	AGT ADD1	3.45e-05	4	84	2	19103106
Pubmed	The Ulip family phosphoproteins--common and specific properties.	DPYSL4 CRMP1	3.45e-05	4	84	2	9652388
Pubmed	Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.	DPYSL4 CRMP1	3.45e-05	4	84	2	25358863
Pubmed	Genetic polymorphisms and the risk of accelerated renal function decline in women.	AGT ADD1	3.45e-05	4	84	2	19274077
Pubmed	Analysis of renin-angiotensin aldosterone system gene polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects.	AGT ADD1	3.45e-05	4	84	2	19243623
Pubmed	D(2) dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence.	AGT ADD1	3.45e-05	4	84	2	11918988
Pubmed	Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system.	DPYSL4 CRMP1	3.45e-05	4	84	2	10664068
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	TULP4 WDR11 UBR4 NAV2 SEMA6A	3.60e-05	153	84	5	10718198
Pubmed	Blood pressure-related genes and the progression of IgA nephropathy.	AGT ADD1	5.74e-05	5	84	2	19729965
Pubmed	Variation in Renin-Angiotensin system and salt-sensitivity genes and the risk of diabetes mellitus associated with the use of thiazide diuretics.	AGT ADD1	5.74e-05	5	84	2	19247266
Pubmed	Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex.	NINL CDC20	5.74e-05	5	84	2	17403670
Pubmed	Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection.	AGT ADD1	5.74e-05	5	84	2	18679149
Pubmed	Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population.	AGT ADD1	5.74e-05	5	84	2	20667857
Pubmed	A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.	DPYSL4 CRMP1	5.74e-05	5	84	2	8973361
Pubmed	Interactions between five candidate genes and antihypertensive drug therapy on blood pressure.	AGT ADD1	5.74e-05	5	84	2	16314886
Pubmed	The contribution of six polymorphisms to cardiovascular risk in a Dutch high-risk primary care population: the HIPPOCRATES project.	AGT ADD1	8.59e-05	6	84	2	19242491
Pubmed	Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.	KCNQ5 AGT	8.59e-05	6	84	2	24838176
Pubmed	Sex-specific effect of the alpha-adducin (G460W) and AGTR1 (A1166C) polymorphism on carotid intima-media thickness.	AGT ADD1	8.59e-05	6	84	2	19620885
Pubmed	The association between arterial stiffness and the angiotensin II type 1 receptor (A1166C) polymorphism is influenced by the use of cardiovascular medication.	AGT ADD1	8.59e-05	6	84	2	19145770
Pubmed	The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age.	AGT ADD1	8.59e-05	6	84	2	19779330
Pubmed	Genetic determinants of nonmodulating hypertension.	AGT ADD1	8.59e-05	6	84	2	14530292
Pubmed	Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family.	DPYSL4 CRMP1	8.59e-05	6	84	2	10956643
Pubmed	Association study of eight candidate genes with renin status in mild-to-moderate hypertension in patients of African ancestry.	AGT ADD1	1.20e-04	7	84	2	11447495
Pubmed	Angiotensin converting enzyme DD genotype is associated with hypertensive crisis.	AGT ADD1	1.20e-04	7	84	2	12394950
Pubmed	Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.	PBRM1 L3MBTL2 TFIP11	1.46e-04	42	84	3	35705031
Pubmed	CRMP-2 binds to tubulin heterodimers to promote microtubule assembly.	DPYSL4 CRMP1	1.60e-04	8	84	2	12134159
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RGL1 USF3 TULP4 WDR11 TBC1D12 EIF3A SLX4	1.95e-04	493	84	7	15368895
Pubmed	Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia.	AGT ADD1	2.05e-04	9	84	2	18413308
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	RGL1 PBRM1 DCAF4L2 TULP4 SYDE2 ANKZF1	2.54e-04	363	84	6	14691545
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TRPM6 LARGE2 PEG3 HJURP PIGW BBS4 TFIP11 ZNF726 SLX4 CRMP1	2.84e-04	1084	84	10	11544199
Pubmed	Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population.	AGT ADD1	3.13e-04	11	84	2	19779464
Pubmed	Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.	AGT ADD1	3.13e-04	11	84	2	20577119
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	JPH1 RYR3	3.75e-04	12	84	2	19095005
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	JPH1 RHBDF2 DTNB NAV2 SEMA6A PARP14 ARHGEF26	4.62e-04	569	84	7	30639242
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF43 ZNF726	5.93e-04	15	84	2	15885501
Pubmed	Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia.	AGT ADD1	5.93e-04	15	84	2	19166692
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	USF3 TULP4 UBR4 HJURP BLZF1 NEDD4	6.22e-04	430	84	6	35044719
Pubmed	The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.	AGT ADD1	6.77e-04	16	84	2	15824464
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PBRM1 POLR1A TBC1D12 CDC20 RPL3 SLX4	7.01e-04	440	84	6	34244565
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	PMS1 CDC20 RPL3 SLX4	7.34e-04	167	84	4	25659891
Pubmed	PEG3 control on the mammalian MSL complex.	HOXC4 PEG3	8.60e-04	18	84	2	28609438
Pubmed	Cloning of ARE-containing genes by AU-motif-directed display.	APOL6 EIF3A	8.60e-04	18	84	2	9828130
Pubmed	Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.	HOXC4 CDC20 ANKZF1 CPED1 RPL3L	8.80e-04	305	84	5	21244100
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HOXC4 USF3 POLR1A KCNQ5 RHBDF2 TULP4 WDR11 DTNB NFASC SEMA6A ARHGEF26	9.01e-04	1489	84	11	28611215
Pubmed	Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.	HOXC4 USF3 CPED1	9.41e-04	79	84	3	22504420
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	PBRM1 ARID4B INTS7 UBR4 RPL3 KRIT1	1.04e-03	475	84	6	31040226
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZFP69 ZNF726	1.06e-03	20	84	2	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZFP69 ZNF726	1.06e-03	20	84	2	2542606
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	UBR4 APOL6 EIF3A RPL3 CRMP1	1.12e-03	322	84	5	26514267
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FAM117A KCNQ5 SYDE2 HJURP SIK2 NAV2 CDC20 NEDD4	1.14e-03	861	84	8	36931259
Pubmed	The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression.	EIF3A EIF2AK2	1.17e-03	21	84	2	35232816
Pubmed	Novel interaction partners of Bardet-Biedl syndrome proteins.	BBS4 EIF3A	1.17e-03	21	84	2	18000879
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PBRM1 POLR1A UBR4 TFIP11 ALDH4A1 EIF3A EIF2AK2 RPL3 ADD1 NMD3	1.28e-03	1318	84	10	30463901
Pubmed	Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.	SHE NRROS	1.41e-03	23	84	2	22535667
Pubmed	CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism.	TFIP11 ANKZF1 EIF2AK2 ADD1	1.46e-03	201	84	4	34917906
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	POLR1A L3MBTL2 WDR11 UBR4 TFIP11 EIF3A CDC20 EIF2AK2 RPL3 NMD3	1.56e-03	1353	84	10	29467282
Pubmed	Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism.	ADD1 CRMP1	1.67e-03	25	84	2	11110696
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	DCAF4L2 WDR11 EIF3A	1.80e-03	99	84	3	34161765
Pubmed	The LIFEdb database in 2006.	L3MBTL2 INTS7 ZNF43 TFIP11 CPED1 C3orf20 RHOT1	1.81e-03	720	84	7	16381901
Pubmed	From ORFeome to biology: a functional genomics pipeline.	L3MBTL2 INTS7 ZNF43 TFIP11 CPED1 C3orf20 RHOT1	1.84e-03	722	84	7	15489336
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	JPH1 PBRM1 L3MBTL2 HJURP TFIP11 EIF3A CDC20 SLX4 ZNF124	1.88e-03	1155	84	9	20360068
Pubmed	Defining the membrane proteome of NK cells.	WDR11 UBR4 EIF3A PARP14 ANKZF1 EIF2AK2 RPL3L RHOT1 NMD3	2.03e-03	1168	84	9	19946888
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SYDE2 UBR4 PIGW NFASC EIF3A STOX1 PARP14	2.05e-03	736	84	7	29676528
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF43 ZNF726	2.24e-03	29	84	2	14563677
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	L3MBTL2 INTS7 SIK2 TFIP11 CPED1 C3orf20 RHOT1	2.27e-03	750	84	7	11230166
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PBRM1 UBR4 DPYSL4 NFASC ARHGEF26 ADD1 CRMP1 NEDD4	2.29e-03	963	84	8	28671696
Cytoband	10q26	WDR11 DPYSL4 EIF3A	1.02e-05	23	84	3	10q26
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	ZNF138 PBRM1 ARID4B WDR11 ZNF43 EIF3A SNAPC1 BLZF1 KRIT1 NMD3 CENPQ	6.99e-06	656	83	11	M18979
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HJURP SHE CDC20 ZFP69 CRMP1 CENPQ	1.10e-06	180	83	6	b35a8c6169f4b548b912af005e92ae7c6596f376
ToppCell	critical-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RGL1 APOL6 PARP14 CPED1 EIF2AK2 ZXDB	1.38e-06	187	83	6	72e4aec49ea0c5fe6cee2a1a46369dbc90cd3fad
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	POLR1A RHBDF2 L3MBTL2 MS4A14 CENPQ	1.71e-05	171	83	5	26b34dc069cc15b75a0c13cb8c5d81e074788160
ToppCell	10x_5'_v1-Neoplastic-Stem-like-OPC-like\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MEIG1 HJURP NFASC SEMA6A CDC20	1.91e-05	175	83	5	cc596907ea1a64ab7b5a8c7d4ad12e6ee59bfed9
ToppCell	10x_5'_v1-Neoplastic-Stem-like\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MEIG1 HJURP NFASC SEMA6A CDC20	1.91e-05	175	83	5	a8400e7e47379901dcab5f2e364c3ff17765b4b9
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JPH1 TRPM6 LARGE2 ARHGEF26 SLX4	1.91e-05	175	83	5	711ace94fa9a763c6ae48171a690953f25deebe4
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PMS1 GPR22 DTNB ABCC12 UNC13C	1.91e-05	175	83	5	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	10x_5'_v1-Neoplastic-Stem-like-OPC-like-OPC-like\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MEIG1 HJURP NFASC SEMA6A CDC20	1.91e-05	175	83	5	8a3abf40146ae3459d97cdf865c1c8f6b92ac639
ToppCell	10x_5'_v1-Neoplastic-Stem-like-OPC-like-OPC-like-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MEIG1 HJURP NFASC SEMA6A CDC20	1.91e-05	175	83	5	378d2b79edac91fc74eee0fb42bb29dd9b07c36f
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HJURP SHE CDC20 ZFP69 CENPQ	1.96e-05	176	83	5	8385435074cc5235b7af7424974f609388fc2cff
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 PCSK6 APOL6 NINL CEMIP	2.19e-05	180	83	5	0b653b1b653b40f3b8711d1312029a4a8a4961db
ToppCell	PBMC-Mild-cDC_9\|Mild / Compartment, Disease Groups and Clusters	RGL1 POLR1A PIGW CDC20 CENPQ	2.43e-05	184	83	5	2e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|lymph-node_spleen / Manually curated celltypes from each tissue	POLR1A HJURP STOX1 NRROS CDC20	2.56e-05	186	83	5	17eec1efad1f5e9ced1eb6bc9eb5dd7ded789c61
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA6A PARP14 EIF2AK2 CRMP1 NEDD4	2.62e-05	187	83	5	f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF43 HJURP UNC13C CDC20 ZNF726	2.62e-05	187	83	5	057569c9437219ecc396aa6e673b1178a2273837
ToppCell	COVID-19-Myeloid-MoAM1,_IL1R2\|Myeloid / Condition, Lineage and Cell class	RGL1 RHBDF2 PARP14 EIF2AK2 CEMIP	2.98e-05	192	83	5	be9d5685fa03563322f147a4b38ed31e4da59487
ToppCell	NS-critical-d_07-13-Myeloid-Monocyte-derived_Macrophage\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RGL1 APOL6 PARP14 CPED1 EIF2AK2	3.05e-05	193	83	5	0dd83b21e164147abfd511a927615c40a28781a2
ToppCell	critical-Myeloid-Monocyte-derived_Macrophage\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RGL1 APOL6 PARP14 CPED1 EIF2AK2	3.13e-05	194	83	5	e36d1fd141bdcbd9ed66a33de6cdfde77189a0c1
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HJURP SHE NRROS CDC20 CENPQ	3.21e-05	195	83	5	eca24039bde02f4677f1f89a373f501c649ec2a5
ToppCell	Bronchus_Control_(B.)-Endothelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	DPYSL4 NFASC SEMA6A BAALC-AS2 CRMP1	3.45e-05	198	83	5	feac39036b5c0ab97b524cc366286942d136d42f
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRPM6 KCNQ5 ABCA13 RPL3 CEMIP	3.45e-05	198	83	5	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRPM6 KCNQ5 ABCA13 RPL3 CEMIP	3.53e-05	199	83	5	94a7867e800df352731796de8c24cba133c29622
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	LARGE2 APOL6 NAV2 ALDH4A1 ARHGEF26	3.62e-05	200	83	5	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AGT ABCC12 ALDH4A1 STOX1 RYR3	3.62e-05	200	83	5	7a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NRROS PARP14 EIF2AK2 CRMP1 NEDD4	3.62e-05	200	83	5	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ARID4B APOL6 EIF3A PARP14 EIF2AK2	3.62e-05	200	83	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK6 NFASC SEMA6A ADD1 NEDD4	3.62e-05	200	83	5	f0c338877e39226a90c4effe12f6501d33542a73
ToppCell	COVID-19_Mild-Neu_1\|World / 5 Neutrophil clusters in COVID-19 patients	LARGE2 USF3 UNC13C CPED1	8.80e-05	125	83	4	e58c208b4355252ceabe04a468dd19a1f436182c
Disease	asparaginase-induced acute pancreatitis	CDC20 C3orf20	2.58e-04	9	80	2	EFO_1001507
Disease	Essential hypertension	AGT ADD1	3.22e-04	10	80	2	cv:C0085580
Disease	Essential hypertension, genetic	AGT ADD1	3.22e-04	10	80	2	cv:CN305331
Disease	HYPERTENSION, ESSENTIAL	AGT ADD1	3.22e-04	10	80	2	145500
Disease	Essential Hypertension	AGT ADD1	4.71e-04	12	80	2	C0085580
Disease	Pre-Eclampsia	AGT STOX1	8.50e-04	16	80	2	C0032914
Disease	axial length measurement	LARGE2 KCNQ5 ZC3H11B	1.21e-03	77	80	3	EFO_0005318
Disease	severe acute respiratory syndrome, COVID-19	DTNB PCSK6 NFASC UNC13C EIF2AK2 CRMP1	1.37e-03	447	80	6	EFO_0000694, MONDO_0100096
Disease	smoking behavior, BMI-adjusted waist-hip ratio	HOXC4 PBRM1 ZC3H11B	1.67e-03	86	80	3	EFO_0004318, EFO_0007788
Disease	Intrahepatic Cholangiocarcinoma	PBRM1 PEG3	1.93e-03	24	80	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	PBRM1 PEG3	1.93e-03	24	80	2	C3805278
Disease	pre-eclampsia (is_implicated_in)	AGT STOX1	2.09e-03	25	80	2	DOID:10591 (is_implicated_in)
Disease	Cholangiocarcinoma	PBRM1 PEG3	2.26e-03	26	80	2	C0206698
Disease	cortex volume change measurement, age at assessment	AGT UNC13C	2.62e-03	28	80	2	EFO_0008007, EFO_0021500
Disease	temporal lobe epilepsy (biomarker_via_orthology)	AGT ADD1	3.21e-03	31	80	2	DOID:3328 (biomarker_via_orthology)
Disease	biological sex	DPYSL4 NFASC SEMA6A ADD1	3.58e-03	230	80	4	PATO_0000047
Disease	refractive error, self reported educational attainment	KCNQ5 RHOT1	3.85e-03	34	80	2	EFO_0004784, MONDO_0004892

Protein segments in the cluster

Peptide	Gene	Start	Entry
TKELKSVVHSAPGWK	TBC1D12	331	O60347
PVKRTWHRHLKDKLT	C2orf16	1521	Q68DN1
HKSRTIPANWKTELK	ARID4B	256	Q4LE39
WTKPVKDPKSKHQTT	BBS4	436	Q96RK4
STRSELRKKWNHLKP	ADAL	336	Q6DHV7
TPTKKEHQKAWALNL	CDC20	106	Q12834
SKKSSWIQEERHLGK	LINC01551	81	Q86U37
KHGKTAASKRKTWQP	CENPQ	61	Q7L2Z9
STSSHLLKTVKPRVW	CPED1	226	A4D0V7
MSLKSWHPQSKTKRV	BAALC-AS2	1	P0C853
TLSKEWKHLKEGART	APOL6	251	Q9BWW8
WGSTDHRKEISKLKQ	FAM117A	146	Q9C073
SSLWTNHLKSLKRDP	ABCA13	771	Q86UQ4
KKWLEHARSSPSLTI	ALDH4A1	401	P30038
HKPLRSTWSQLSAVK	ARHGEF26	411	Q96DR7
QKKLSWTFLNKTLHP	CEMIP	156	Q8WUJ3
PWKDKNCTSRLDAHK	AGT	156	P01019
QIHKLDPSWKERKVT	HJURP	366	Q8NCD3
WSRRDKKENKHLAPT	RGL1	261	Q9NZL6
LKLLANKTPHTWSRE	INTS7	276	Q9NVH2
EASDLKVIHWNSPKK	LARGE2	331	Q8N3Y3
SKEQESRLPSHWLKS	PBRM1	1641	Q86U86
RAKLKFSTSEKLHWP	KIAA0895	51	Q8NCT3
HNTKTTTWEDPRLKI	NEDD4	861	P46934
SRKHHSLQSPWKKAV	BLZF1	41	Q9H2G9
PKSKLLRWTTNKKHH	IP6K2	106	Q9UHH9
PTKKAKVLHKAAWSA	L3MBTL2	136	Q969R5
KSVSIATWKPHLKAL	KCNQ5	386	Q9NR82
VHKPSANKWSPSKSV	JPH1	581	Q9HDC5
RKKVQIHSWDPSSLA	DCAF4L2	56	Q8NA75
KTSRPAHLKASDWKV	PCSK6	451	P29122
NKHSIDKVTSRWIPL	RHOT1	86	Q8IXI2
KIIPKTLTWHSAKRE	LY75	1116	O60449
PVTKLKSKAPHWTNR	KRIT1	586	O00522
HLSATKPKKSWAPNL	PEG3	6	Q9GZU2
QRLTKSKVDIPAHWS	PARP14	1596	Q460N5
KHDPSLKLTVSWLKD	NFASC	546	O94856
IWNPKATKIISAKTH	DPYSL4	411	O14531
LTVWKKSPEKNERHT	EIF2AK2	536	P19525
KSKKHRTWQKIHEPI	EIF3A	36	Q14152
SPQTHWKTVREERKK	ANKZF1	361	Q9H8Y5
HPLSRDSKITSWKKQ	C3orf20	886	Q8ND61
WKKDHRLPNTKVRSA	HOXC4	211	P09017
SWKSPAKKLSHAISK	DTNB	291	O60941
QIKDWLSPKRHSVDK	MS4A14	536	Q96JA4
IHNSWIDPKRNKKIT	GPR22	401	Q99680
PTSAWNLAQKHKLKT	PMS1	656	P54277
IWDPDKLKTITAKSH	CRMP1	411	Q14194
KPLLQVIKSRCHWSS	NRROS	676	Q86YC3
GESWKQHIKDKTRSL	PLA2G4D	546	Q86XP0
VKPKSVSHAKKWSEE	MEIG1	6	Q5JSS6
HKPLNSITVSKKRNW	SYDE2	276	Q5VT97
AIKKWQSKHPNTLLR	POLR1A	1071	O95602
VTSRWHTKKLPRKTH	RPL3	231	P39023
VTSRWHTKKLPRKTH	RPL3L	231	Q92901
AATKPWRSKSLSVKH	NAV2	376	Q8IVL1
PSKRLTIAQIKEHKW	SIK2	256	Q9H0K1
LESSTRVKPSKAWSH	NINL	271	Q9Y2I6
LTWEHEASRKSTPKK	ABCC12	441	Q96J65
WKLIQSPVTNKKHSE	PIGW	411	Q7Z7B1
KKQRVTKWQASEPAH	SLX4	121	Q8IY92
WHKDRKNPSLKSKTN	SNAPC1	226	Q16533
PKSKTKWTKEDGHRT	ADD1	466	P35611
LSDDWAAKKSPKISR	TULP4	521	Q9NRJ4
KKHLQDVDTWKSRCP	ZXDB	536	P98169
TFNWSTNLSKPKKIH	ZNF138	146	P52744
RKHSTCKKLPHSWSN	TRPM6	1241	Q9BX84
PKSWHSRLSIDLSDK	UNC13C	776	Q8NB66
QPLRSKKAVWHKLLS	RYR3	3466	Q15413
LWRSLSRKEKPKTEH	STOX1	316	Q6ZVD7
TLRTVKHDSKWLKEP	SEMA6A	206	Q9H2E6
IQKKSGKWHTLTDLR	ERVK-10	76	P10266
PTIHWKGNLKNSKVS	USF3	121	Q68DE3
WHLTKQLPTKSSQKV	ZC3H11B	606	A0A1B0GTU1
KAFNWPSTLTKHKRI	ZNF43	321	P17038
STLWKHKKTHTGEKP	ZNF124	331	Q15973
KAFIWPSTLTKHKRI	ZNF726	376	A6NNF4
PPKTKRASDKHIQWL	SH2D4B	56	Q5SQS7
KKEHNSSVPWSSLEK	TCHHL1	766	Q5QJ38
LEWSPSHNLKSLRKK	WDR11	616	Q9BZH6
HRQKSWTQKILKPAL	SHE	361	Q5VZ18
RWHKAKKVQLTPGQT	UBR4	3611	Q5T4S7
RLKKSQPRTWAAHTT	RHBDF2	56	Q6PJF5
RSKLSSALQKWHPSD	TFIP11	571	Q9UBB9
TEASTWVKLQHPKKA	ZFP69	11	Q49AA0
NTWSRKHLKLSPKSP	LIPK	121	Q5VXJ0
VWTEPHSKRLKVKLT	NMD3	101	Q96D46