Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	signaling receptor complex adaptor activity	SORBS1 GNB5 GNB4 GNB1 GNB2 NCK2	1.64e-07	54	91	6	GO:0030159
GeneOntologyMolecularFunction	U3 snoRNA binding	BMS1 TBL3 UTP25	1.47e-05	11	91	3	GO:0034511
GeneOntologyMolecularFunction	signaling adaptor activity	SORBS1 GNB5 GNB4 GNB1 GNB2 NCK2	2.75e-05	129	91	6	GO:0035591
GeneOntologyMolecularFunction	snoRNA binding	BMS1 TBL3 UTP25	4.95e-04	34	91	3	GO:0030515
GeneOntologyMolecularFunction	interleukin-1 receptor activity	IL1RAPL2 IL1RAP	5.65e-04	8	91	2	GO:0004908
GeneOntologyCellularComponent	heterotrimeric G-protein complex	GNB5 GNB4 GNB1 GNB2	2.04e-05	35	97	4	GO:0005834
GeneOntologyCellularComponent	GATOR2 complex	SEH1L SZT2 MIOS	2.07e-05	12	97	3	GO:0061700
GeneOntologyCellularComponent	GTPase complex	GNB5 GNB4 GNB1 GNB2	3.87e-05	41	97	4	GO:1905360
GeneOntologyCellularComponent	Seh1-associated complex	SEH1L SZT2 MIOS	5.19e-05	16	97	3	GO:0035859
GeneOntologyCellularComponent	extrinsic component of cytoplasmic side of plasma membrane	GNB5 GNB4 GNB1 GNB2	1.33e-04	56	97	4	GO:0031234
Domain	Guanine_nucleotide-bd_bsu	GNB5 GNB4 GNB1 GNB2	2.87e-09	5	93	4	IPR016346
Domain	-	SEH1L SEMA5A TBL3 WDR11 GNB5 MIOS GNB4 IFT122 SEMA6A DCAF11 GNB1 GNB2	9.68e-08	333	93	12	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEH1L SEMA5A TBL3 WDR11 GNB5 MIOS GNB4 IFT122 SEMA6A DCAF11 GNB1 GNB2	1.03e-07	335	93	12	IPR015943
Domain	Gprotein_B	GNB5 GNB4 GNB1 GNB2	1.18e-07	10	93	4	IPR001632
Domain	G-protein_beta_WD-40_rep	SEH1L TBL3 GNB5 GNB4 DCAF11 GNB1 GNB2	2.17e-07	85	93	7	IPR020472
Domain	NPIP	NPIPB3 NPIPB5 NPIPB2 NPIPB13	5.55e-07	14	93	4	IPR009443
Domain	WD40	SEH1L TBL3 WDR11 GNB5 MIOS GNB4 IFT122 DCAF11 GNB1 GNB2	8.88e-07	268	93	10	SM00320
Domain	WD40_repeat	SEH1L TBL3 WDR11 GNB5 MIOS GNB4 IFT122 DCAF11 GNB1 GNB2	1.02e-06	272	93	10	IPR001680
Domain	WD_REPEATS_1	SEH1L TBL3 WDR11 GNB5 MIOS GNB4 IFT122 DCAF11 GNB1 GNB2	1.24e-06	278	93	10	PS00678
Domain	WD_REPEATS_2	SEH1L TBL3 WDR11 GNB5 MIOS GNB4 IFT122 DCAF11 GNB1 GNB2	1.28e-06	279	93	10	PS50082
Domain	WD_REPEATS_REGION	SEH1L TBL3 WDR11 GNB5 MIOS GNB4 IFT122 DCAF11 GNB1 GNB2	1.28e-06	279	93	10	PS50294
Domain	WD40_repeat_dom	SEH1L TBL3 WDR11 GNB5 MIOS GNB4 IFT122 DCAF11 GNB1 GNB2	2.24e-06	297	93	10	IPR017986
Domain	WD40	SEH1L TBL3 WDR11 GNB5 GNB4 IFT122 DCAF11 GNB1 GNB2	5.75e-06	259	93	9	PF00400
Domain	SOHO	SORBS2 SORBS1	7.33e-05	3	93	2	PS50831
Domain	Sorb	SORBS2 SORBS1	7.33e-05	3	93	2	SM00459
Domain	Relaxin	RLN1 RLN2	7.33e-05	3	93	2	IPR022421
Domain	Sorb	SORBS2 SORBS1	7.33e-05	3	93	2	PF02208
Domain	SoHo_dom	SORBS2 SORBS1	7.33e-05	3	93	2	IPR003127
Domain	WD40_repeat_CS	TBL3 WDR11 GNB5 GNB4 GNB1 GNB2	1.70e-04	164	93	6	IPR019775
Domain	Insulin_family	RLN1 RLN2	3.63e-04	6	93	2	IPR022352
Domain	Insulin_CS	RLN1 RLN2	8.63e-04	9	93	2	IPR022353
Domain	-	RLN1 RLN2	8.63e-04	9	93	2	1.10.100.10
Domain	Insulin	RLN1 RLN2	1.08e-03	10	93	2	PF00049
Domain	INSULIN	RLN1 RLN2	1.08e-03	10	93	2	PS00262
Domain	IL-1_rcpt_fam	IL1RAPL2 IL1RAP	1.31e-03	11	93	2	IPR015621
Domain	Insulin	RLN1 RLN2	1.31e-03	11	93	2	IPR004825
Domain	Insulin-like	RLN1 RLN2	1.31e-03	11	93	2	IPR016179
Domain	IlGF	RLN1 RLN2	1.31e-03	11	93	2	SM00078
Domain	Lipocalin_CS	AMBP LCN6	1.57e-03	12	93	2	IPR022272
Domain	Oxysterol-bd	OSBPL7 OSBPL8	1.57e-03	12	93	2	IPR000648
Domain	Oxysterol-bd_CS	OSBPL7 OSBPL8	1.57e-03	12	93	2	IPR018494
Domain	Oxysterol_BP	OSBPL7 OSBPL8	1.57e-03	12	93	2	PF01237
Domain	OSBP	OSBPL7 OSBPL8	1.57e-03	12	93	2	PS01013
Domain	Sushi	TPO CSMD2 SRPX	2.21e-03	52	93	3	PF00084
Domain	CCP	TPO CSMD2 SRPX	2.47e-03	54	93	3	SM00032
Domain	SUSHI	TPO CSMD2 SRPX	2.74e-03	56	93	3	PS50923
Domain	Sushi_SCR_CCP_dom	TPO CSMD2 SRPX	2.88e-03	57	93	3	IPR000436
Domain	Gal_Oxase/kelch_b-propeller	TBL3 KLHL12 KLHL17	3.18e-03	59	93	3	IPR011043
Domain	LIPOCALIN	AMBP LCN6	3.18e-03	17	93	2	PS00213
Domain	Lipocalin	AMBP LCN6	3.56e-03	18	93	2	IPR002345
Domain	Semaphorin	SEMA5A SEMA6A	4.40e-03	20	93	2	IPR027231
Domain	TIR	IL1RAPL2 IL1RAP	4.84e-03	21	93	2	SM00255
Domain	TIR	IL1RAPL2 IL1RAP	5.31e-03	22	93	2	PF01582
Domain	-	SYNE1 CEP95 UTRN	5.35e-03	71	93	3	1.10.418.10
Domain	Actinin_actin-bd_CS	SYNE1 UTRN	5.80e-03	23	93	2	IPR001589
Domain	Spectrin	SYNE1 UTRN	5.80e-03	23	93	2	PF00435
Domain	-	IL1RAPL2 IL1RAP	5.80e-03	23	93	2	3.40.50.10140
Domain	ACTININ_2	SYNE1 UTRN	5.80e-03	23	93	2	PS00020
Domain	ACTININ_1	SYNE1 UTRN	5.80e-03	23	93	2	PS00019
Domain	CH-domain	SYNE1 CEP95 UTRN	6.23e-03	75	93	3	IPR001715
Domain	TIR	IL1RAPL2 IL1RAP	6.30e-03	24	93	2	PS50104
Domain	TIR_dom	IL1RAPL2 IL1RAP	6.83e-03	25	93	2	IPR000157
Domain	SH3_9	SORBS2 SORBS1 NCK2	6.94e-03	78	93	3	PF14604
Domain	-	KLHL12 KLHL17	7.94e-03	27	93	2	2.130.10.80
Domain	Fibrinogen_C	ITLN2 ANGPTL4	7.94e-03	27	93	2	PF00147
Domain	FBG	ITLN2 ANGPTL4	9.13e-03	29	93	2	SM00186
Domain	Spectrin_repeat	SYNE1 UTRN	9.13e-03	29	93	2	IPR002017
Domain	-	ITLN2 ANGPTL4	9.75e-03	30	93	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	ITLN2 ANGPTL4	9.75e-03	30	93	2	IPR014716
Pathway	REACTOME_GPER1_SIGNALING	FN1 GNB5 GNB4 GNB1 GNB2	2.23e-07	27	72	5	MM15664
Pathway	REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING	GRIK5 GNB5 GNB4 GNB1 GNB2	3.89e-07	30	72	5	M18193
Pathway	KEGG_MEDICUS_REFERENCE_CCR2_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2 IKBKB	4.63e-07	31	72	5	M47540
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2 IKBKB	4.63e-07	31	72	5	M47541
Pathway	REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING	GRIK5 GNB5 GNB4 GNB1 GNB2	5.46e-07	32	72	5	MM15143
Pathway	REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR	GNB5 GNB4 GNB1 GNB2	2.29e-06	19	72	4	MM15021
Pathway	REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR	GNB5 GNB4 GNB1 GNB2	2.29e-06	19	72	4	M926
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_CDC42	GNB5 GNB4 GNB1 GNB2	2.85e-06	20	72	4	MM15572
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_CDC42	GNB5 GNB4 GNB1 GNB2	2.85e-06	20	72	4	M27853
Pathway	REACTOME_GPER1_SIGNALING	FN1 GNB5 GNB4 GNB1 GNB2	3.15e-06	45	72	5	M45008
Pathway	REACTOME_PRESYNAPTIC_FUNCTION_OF_KAINATE_RECEPTORS	GNB5 GNB4 GNB1 GNB2	3.51e-06	21	72	4	M27409
Pathway	REACTOME_PRESYNAPTIC_FUNCTION_OF_KAINATE_RECEPTORS	GNB5 GNB4 GNB1 GNB2	3.51e-06	21	72	4	MM15159
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12	GNB5 GNB4 GNB1 GNB2	4.27e-06	22	72	4	MM15016
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12	GNB5 GNB4 GNB1 GNB2	4.27e-06	22	72	4	M841
Pathway	REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION	GNB5 GNB4 GNB1 GNB2	5.15e-06	23	72	4	MM15033
Pathway	KEGG_MEDICUS_REFERENCE_LPAR_GNB_G_RHO_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	5.15e-06	23	72	4	M47549
Pathway	REACTOME_G_PROTEIN_ACTIVATION	GNB5 GNB4 GNB1 GNB2	6.15e-06	24	72	4	M13115
Pathway	REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR	GNB5 GNB4 GNB1 GNB2	6.15e-06	24	72	4	MM15088
Pathway	REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR	GNB5 GNB4 GNB1 GNB2	6.15e-06	24	72	4	M18308
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_PI3K_AKT_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	6.15e-06	24	72	4	M47460
Pathway	REACTOME_G_PROTEIN_ACTIVATION	GNB5 GNB4 GNB1 GNB2	6.15e-06	24	72	4	MM14794
Pathway	REACTOME_NEURONAL_SYSTEM	SORBS2 KCNH7 GRIK5 IL1RAPL2 GNB5 GNB4 GJA10 GNB1 GNB2 IL1RAP	7.29e-06	335	72	10	MM14503
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1	GNB5 GNB4 GNB1 GNB2	7.30e-06	25	72	4	MM15056
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1	GNB5 GNB4 GNB1 GNB2	7.30e-06	25	72	4	M811
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA	GNB5 GNB4 GNB1 GNB2	7.30e-06	25	72	4	M14301
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	FN1 RLN1 RLN2 GNB5 GNB4 GNB1 GNB2	8.10e-06	143	72	7	MM15055
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA	GNB5 GNB4 GNB1 GNB2	8.59e-06	26	72	4	MM15017
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	8.59e-06	26	72	4	M47561
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	8.59e-06	26	72	4	M47562
Pathway	KEGG_MEDICUS_REFERENCE_CCR5_GNB_G_PLCB_G_PKC_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	8.59e-06	26	72	4	M47557
Pathway	KEGG_MEDICUS_REFERENCE_CXCR_GNB_G_PI3K_AKT_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	8.59e-06	26	72	4	M47456
Pathway	KEGG_MEDICUS_REFERENCE_CXCR_GNB_G_ERK_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	1.00e-05	27	72	4	M47454
Pathway	REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION	GNB5 GNB4 GNB1 GNB2	1.17e-05	28	72	4	M10679
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_PI3K_JNK_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	1.35e-05	29	72	4	M47466
Pathway	REACTOME_ACTIVATION_OF_G_PROTEIN_GATED_POTASSIUM_CHANNELS	GNB5 GNB4 GNB1 GNB2	1.55e-05	30	72	4	MM14542
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	GNB5 GNB4 GNB1 GNB2	1.77e-05	31	72	4	MM15094
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	1.77e-05	31	72	4	M47554
Pathway	KEGG_MEDICUS_REFERENCE_CCR_CXCR_GNB_G_PI3K_RAC_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	1.77e-05	31	72	4	M47455
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_ERK_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	1.77e-05	31	72	4	M47459
Pathway	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS	GNB5 GNB4 GNB1 GNB2	2.02e-05	32	72	4	M861
Pathway	REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING	GNB5 GNB4 GNB1 GNB2	2.02e-05	32	72	4	M14309
Pathway	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS	GNB5 GNB4 GNB1 GNB2	2.02e-05	32	72	4	MM15148
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PI3K_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	2.02e-05	32	72	4	M47962
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	GNB5 GNB4 GNB1 GNB2	2.02e-05	32	72	4	MM14983
Pathway	REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING	GNB5 GNB4 GNB1 GNB2	2.29e-05	33	72	4	MM15027
Pathway	REACTOME_SIGNAL_AMPLIFICATION	GNB5 GNB4 GNB1 GNB2	2.29e-05	33	72	4	MM15020
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	GNB5 GNB4 GNB1 GNB2	2.29e-05	33	72	4	MM15058
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNB_G_RHO_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2	2.29e-05	33	72	4	M47550
Pathway	REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS	GNB5 GNB4 GNB1 GNB2	2.29e-05	33	72	4	MM15066
Pathway	REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS	GNB5 GNB4 GNB1 GNB2	2.29e-05	33	72	4	M10322
Pathway	REACTOME_SIGNAL_AMPLIFICATION	GNB5 GNB4 GNB1 GNB2	2.29e-05	33	72	4	M9379
Pathway	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	GNB5 GNB4 GNB1 GNB2	2.91e-05	35	72	4	M1075
Pathway	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	GNB5 GNB4 GNB1 GNB2	3.26e-05	36	72	4	MM14544
Pathway	REACTOME_COOPERATION_OF_PDCL_PHLP1_AND_TRIC_CCT_IN_G_PROTEIN_BETA_FOLDING	GNB5 GNB4 GNB1 GNB2	4.05e-05	38	72	4	M27656
Pathway	REACTOME_CHAPERONIN_MEDIATED_PROTEIN_FOLDING	GNB5 GNB4 GNB1 GNB2	4.49e-05	39	72	4	MM15003
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	GNB5 GNB4 GNB1 GNB2	4.97e-05	40	72	4	MM15115
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	GNB5 GNB4 GNB1 GNB2	6.05e-05	42	72	4	M791
Pathway	REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION	GNB5 GNB4 GNB1 GNB2	6.64e-05	43	72	4	M29837
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	GNB5 GNB4 GNB1 GNB2	6.64e-05	43	72	4	M933
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	GNB5 GNB4 GNB1 GNB2	6.64e-05	43	72	4	M954
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	GNB5 GNB4 GNB1 GNB2	7.28e-05	44	72	4	MM15709
Pathway	REACTOME_CA2_PATHWAY	GNB5 GNB4 GNB1 GNB2	7.96e-05	45	72	4	MM15040
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	GNB5 GNB4 GNB1 GNB2	1.03e-04	48	72	4	M10775
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	PTCH1 GNB5 GNB4 GNB1 GNB2	1.16e-04	94	72	5	M797
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	GNB5 GNB4 GNB1 GNB2	1.41e-04	52	72	4	M920
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNH7 GNB5 GNB4 GNB1 GNB2	1.42e-04	98	72	5	MM14545
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	FN1 RLN2 GNB5 GNB4 GNB1 GNB2	1.48e-04	157	72	6	M4904
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNH7 GNB5 GNB4 GNB1 GNB2	1.79e-04	103	72	5	M1073
Pathway	REACTOME_NEURONAL_SYSTEM	KCNH7 GRIK5 IL1RAPL2 GNB5 GNB4 GJA10 GNB1 GNB2 IL1RAP	2.34e-04	411	72	9	M735
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	GNB5 GNB4 GNB1 GNB2	2.46e-04	60	72	4	MM15708
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	GNB5 GNB4 GNB1 GNB2	2.46e-04	60	72	4	MM14964
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	GNB5 GNB4 GNB1 GNB2	2.46e-04	60	72	4	M976
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	GNB5 GNB4 GNB1 GNB2	2.62e-04	61	72	4	MM15071
Pathway	REACTOME_CA2_PATHWAY	GNB5 GNB4 GNB1 GNB2	2.79e-04	62	72	4	M27321
Pathway	WP_RAS_SIGNALING	FLT3 GNB5 GNB4 GNB1 GNB2 IKBKB	3.49e-04	184	72	6	M39764
Pathway	REACTOME_OPIOID_SIGNALLING	GNB5 GNB4 GNB1 GNB2	4.69e-04	71	72	4	MM14491
Pathway	REACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING	GNB5 GNB4 GNB1 GNB2	4.69e-04	71	72	4	MM15590
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	GNB5 GNB4 GNB1 GNB2	4.95e-04	72	72	4	MM14631
Pathway	REACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING	GNB5 GNB4 GNB1 GNB2	5.78e-04	75	72	4	M27874
Pathway	REACTOME_PLATELET_HOMEOSTASIS	GNB5 GNB4 GNB1 GNB2	6.08e-04	76	72	4	MM15051
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	GNB4 GNB1 GNB2	6.24e-04	33	72	3	M11575
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	GNB5 GNB4 GNB1 GNB2	6.39e-04	77	72	4	MM15044
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	GNB5 GNB4 GNB1 GNB2	6.71e-04	78	72	4	M1921
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	GNB5 GNB4 GNB1 GNB2	7.38e-04	80	72	4	M800
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	GRIK5 GNB5 GNB4 GNB1 GNB2	8.38e-04	144	72	5	MM14501
Pathway	REACTOME_PLATELET_HOMEOSTASIS	GNB5 GNB4 GNB1 GNB2	9.69e-04	86	72	4	M916
Pathway	REACTOME_RELAXIN_RECEPTORS	RLN1 RLN2	1.13e-03	10	72	2	MM15111
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	RLN1 RLN2 GNB5 GNB4 GNB1	1.13e-03	154	72	5	MM15974
Pathway	REACTOME_OPIOID_SIGNALLING	GNB5 GNB4 GNB1 GNB2	1.15e-03	90	72	4	M6467
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	RLN1 GNB5 GNB4 GNB1 GNB2	1.20e-03	156	72	5	M39475
Pathway	WP_CHEMOKINE_SIGNALING	GNB5 GNB4 GNB1 GNB2 IKBKB	1.54e-03	165	72	5	M39400
Pathway	REACTOME_PROTEIN_FOLDING	GNB5 GNB4 GNB1 GNB2	1.57e-03	98	72	4	M776
Pathway	WP_PI3KAKT_SIGNALING	FLT3 FN1 GNB5 GNB4 GNB1 GNB2 IKBKB	1.69e-03	339	72	7	M39736
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	GNB5 GNB4 GNB1 GNB2	2.25e-03	108	72	4	M17034
Pathway	KEGG_CHEMOKINE_SIGNALING_PATHWAY	GNB5 GNB4 GNB1 GNB2 IKBKB	2.72e-03	188	72	5	M4844
Pathway	REACTOME_AMINO_ACIDS_REGULATE_MTORC1	SEH1L SZT2 MIOS	2.77e-03	55	72	3	M29825
Pathway	REACTOME_AMINO_ACIDS_REGULATE_MTORC1	SEH1L SZT2 MIOS	2.92e-03	56	72	3	MM15667
Pathway	REACTOME_RRNA_MODIFICATION_IN_THE_NUCLEUS_AND_CYTOSOL	BMS1 TBL3 UTP25	3.55e-03	60	72	3	M27613
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	GNB5 GNB4 GNB1 GNB2	3.59e-03	123	72	4	MM14988
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	GRIK5 GNB5 GNB4 GNB1 GNB2	3.94e-03	205	72	5	M752
Pubmed	Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits.	GNB5 GNB4 GNB1 GNB2	1.00e-09	6	101	4	16884933
Pubmed	Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.	GNB5 GNB4 GNB1 GNB2	8.35e-09	9	101	4	10339615
Pubmed	Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.	GNB5 GNB4 GNB1 GNB2	1.39e-08	10	101	4	28334111
Pubmed	Expression of olfactory receptors, G-proteins and AxCAMs during the development and maturation of olfactory sensory neurons in the mouse.	GNB5 GNB4 GNB1 GNB2	1.39e-08	10	101	4	9733924
Pubmed	The G protein subunit gene families.	GNB5 GNB4 GNB1 GNB2	2.18e-08	11	101	4	10644457
Pubmed	Specificities of Gβγ subunits for the SNARE complex before and after stimulation of α2a-adrenergic receptors.	GNB5 GNB4 GNB1 GNB2	2.18e-08	11	101	4	34932372
Pubmed	A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation.	GNB5 GNB4 GNB1 GNB2	2.18e-08	11	101	4	25982117
Pubmed	Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice.	GNB5 GNB4 GNB1 GNB2	3.26e-08	12	101	4	20186915
Pubmed	Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers.	GNB5 GNB4 GNB1 GNB2	3.26e-08	12	101	4	16301321
Pubmed	Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families.	GNB5 GNB4 GNB1 GNB2	3.26e-08	12	101	4	8636150
Pubmed	Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.	GNB4 GNB1 GNB2	9.49e-08	4	101	3	1543505
Pubmed	The role of G protein beta subunits in the release of ATP from human erythrocytes.	GNB4 GNB1 GNB2	9.49e-08	4	101	3	12512701
Pubmed	Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.	GNB5 GNB4 GNB1 GNB2	1.55e-07	17	101	4	19376773
Pubmed	Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.	GNB4 GNB1 GNB2	4.72e-07	6	101	3	16371464
Pubmed	G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development.	GNB5 GNB4 GNB1 GNB2	1.30e-06	28	101	4	8858601
Pubmed	A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.	GNB5 GNB1 GNB2	1.32e-06	8	101	3	9789084
Pubmed	Gβγ interacts with mTOR and promotes its activation.	GNB5 GNB1 GNB2	1.32e-06	8	101	3	24462769
Pubmed	The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8.	GNB4 GNB1 GNB2	1.32e-06	8	101	3	2328987
Pubmed	Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit.	FN1 GNB1 GNB2	1.97e-06	9	101	3	16498633
Pubmed	Human Multisubunit E3 Ubiquitin Ligase Required for Heterotrimeric G-Protein β-Subunit Ubiquitination and Downstream Signaling.	GNB4 GNB1 GNB2	5.13e-06	12	101	3	34342229
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SYNE1 DHX38 BMS1 MAP3K20 TMEM214 FOXJ3 TBL3 UTP25 WDR11 ELAPOR1 OSBPL8 MIOS UQCRC1 UTRN KIF22 NOL8	6.47e-06	1497	101	16	31527615
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	FN1 CEP350 OSBPL8 GNB1 UTRN NOL8	7.36e-06	159	101	6	30581152
Pubmed	Two human relaxin genes are on chromosome 9.	RLN1 RLN2	8.35e-06	2	101	2	6548703
Pubmed	Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones.	RLN1 RLN2	8.35e-06	2	101	2	6548702
Pubmed	Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.	GNB1 GNB2	8.35e-06	2	101	2	20525682
Pubmed	Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species.	RLN1 RLN2	8.35e-06	2	101	2	8735594
Pubmed	Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer.	RLN1 RLN2	8.35e-06	2	101	2	26499396
Pubmed	Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination.	RLN1 RLN2	8.35e-06	2	101	2	2040595
Pubmed	RNAi-mediated knockdown of relaxin decreases in vitro proliferation and invasiveness of osteosarcoma MG-63 cells by inhibition of MMP-9.	RLN1 RLN2	8.35e-06	2	101	2	23661525
Pubmed	Structural characterization by mass spectrometry of native and recombinant human relaxin.	RLN1 RLN2	8.35e-06	2	101	2	2076464
Pubmed	Relaxin promotes prostate cancer progression.	RLN1 RLN2	8.35e-06	2	101	2	17363522
Pubmed	Relaxin, insulin and diabetes: an intriguing connection.	RLN1 RLN2	8.35e-06	2	101	2	22698078
Pubmed	Isolation and analysis of the 3'-untranslated regions of the human relaxin H1 and H2 genes.	RLN1 RLN2	8.35e-06	2	101	2	10750025
Pubmed	Human seminal relaxin is a product of the same gene as human luteal relaxin.	RLN1 RLN2	8.35e-06	2	101	2	1572287
Pubmed	Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping.	RLN1 RLN2	8.35e-06	2	101	2	10601981
Pubmed	Serum relaxin levels in benign hypermobility syndrome.	RLN1 RLN2	8.35e-06	2	101	2	25322737
Pubmed	The relaxin peptide family--structure, function and clinical applications.	RLN1 RLN2	8.35e-06	2	101	2	20858209
Pubmed	Expression of the human relaxin H1 gene in the decidua, trophoblast, and prostate.	RLN1 RLN2	8.35e-06	2	101	2	2005217
Pubmed	Relaxin: structures, functions, promises, and nonevolution.	RLN1 RLN2	8.35e-06	2	101	2	7958621
Pubmed	Ggamma subunit-selective G protein beta 5 mutant defines regulators of G protein signaling protein binding requirement for nuclear localization.	GNB5 GNB1	8.35e-06	2	101	2	12551930
Pubmed	X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.	RLN1 RLN2	8.35e-06	2	101	2	1656049
Pubmed	Serum relaxin as a diagnostic and prognostic marker in patients with epithelial ovarian cancer.	RLN1 RLN2	8.35e-06	2	101	2	29060928
Pubmed	Relaxin gene expression in human reproductive tissues by in situ hybridization.	RLN1 RLN2	8.35e-06	2	101	2	7829601
Pubmed	Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.	GNB4 GNB1 GNB2	1.05e-05	15	101	3	12486123
Pubmed	SZT2 dictates GATOR control of mTORC1 signalling.	SEH1L SZT2 MIOS	1.30e-05	16	101	3	28199315
Pubmed	Relaxin regulates collagen overproduction associated with experimental progressive renal fibrosis.	RLN1 RLN2	2.50e-05	3	101	2	15956704
Pubmed	The relaxin gene-knockout mouse: a model of progressive fibrosis.	RLN1 RLN2	2.50e-05	3	101	2	15956703
Pubmed	Investigating the role of relaxin in the regulation of airway fibrosis in animal models of acute and chronic allergic airway disease.	RLN1 RLN2	2.50e-05	3	101	2	15956707
Pubmed	Abnormal extracellular matrix remodelling in the cervix of pregnant relaxin-deficient mice is not associated with reduced matrix metalloproteinase expression or activity.	RLN1 RLN2	2.50e-05	3	101	2	29533760
Pubmed	Isolation and characterization of fibronectin-alpha 1-microglobulin complex in rat plasma.	AMBP FN1	2.50e-05	3	101	2	7519849
Pubmed	Human medullary thyroid carcinoma: a source and potential target for relaxin-like hormones.	RLN1 RLN2	2.50e-05	3	101	2	15956746
Pubmed	Relaxin treatment reduces angiotensin II-induced vasoconstriction in pregnancy and protects against endothelial dysfunction†.	RLN1 RLN2	2.50e-05	3	101	2	28379296
Pubmed	Relaxin: new peptides, receptors and novel actions.	RLN1 RLN2	2.50e-05	3	101	2	12826326
Pubmed	Relaxin regulates myofibroblast contractility and protects against lung fibrosis.	RLN1 RLN2	2.50e-05	3	101	2	21983071
Pubmed	Relaxin-1-deficient mice develop an age-related progression of renal fibrosis.	RLN1 RLN2	2.50e-05	3	101	2	15149318
Pubmed	The relaxin gene knockout mouse: a model of progressive scleroderma.	RLN1 RLN2	2.50e-05	3	101	2	16185267
Pubmed	G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13).	GNB5 GNB2	2.50e-05	3	101	2	11675383
Pubmed	Mechanisms of relaxin action in the reproductive tract: studies in the relaxin-deficient (Rlx-/-) mouse.	RLN1 RLN2	2.50e-05	3	101	2	15956691
Pubmed	Reversal by relaxin of altered ileal spontaneous contractions in dystrophic (mdx) mice through a nitric oxide-mediated mechanism.	RLN1 RLN2	2.50e-05	3	101	2	17522128
Pubmed	The INSL4 gene maps close to WI-5527 at 9p24.1-->p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome.	RLN1 RLN2	2.50e-05	3	101	2	9730618
Pubmed	Site-related Effects of Relaxin in the Gastrointestinal Tract Through Nitric Oxide Signalling: An Updated Report.	RLN1 RLN2	2.50e-05	3	101	2	28606038
Pubmed	Mouse relaxin: synthesis and biological activity of the first relaxin with an unusual crosslinking pattern.	RLN1 RLN2	2.50e-05	3	101	2	8216305
Pubmed	Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.	RLN1 RLN2	2.50e-05	3	101	2	15155573
Pubmed	Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.	GNB1 GNB2	2.50e-05	3	101	2	25485910
Pubmed	Mice without a functional relaxin gene are unable to deliver milk to their pups.	RLN1 RLN2	2.50e-05	3	101	2	9886856
Pubmed	Relaxin 2 is functional at the ocular surface and promotes corneal wound healing.	RLN1 RLN2	2.50e-05	3	101	2	23111608
Pubmed	Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis.	RLN1 RLN2	2.50e-05	3	101	2	12424226
Pubmed	Selective association of G protein beta(4) with gamma(5) and gamma(12) subunits in bovine tissues.	GNB4 GNB2	2.50e-05	3	101	2	10409705
Pubmed	The mouse relaxin gene: nucleotide sequence and expression.	RLN1 RLN2	2.50e-05	3	101	2	8452637
Pubmed	[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2].	SORBS2 SORBS1	2.50e-05	3	101	2	12510380
Pubmed	Polymorphisms in the promoter region of relaxin-2 and preterm birth: involvement of relaxin in the etiology of preterm birth.	RLN1 RLN2	2.50e-05	3	101	2	20023247
Pubmed	Skeletal myoblasts overexpressing relaxin improve differentiation and communication of primary murine cardiomyocyte cell cultures.	RLN1 RLN2	2.50e-05	3	101	2	19465027
Pubmed	Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes.	GNB1 GNB2	2.50e-05	3	101	2	11913780
Pubmed	Normal mammary gland growth and lactation capacity in pregnant relaxin-deficient mice.	RLN1 RLN2	2.50e-05	3	101	2	19383261
Pubmed	Anti-atherosclerotic effects of serelaxin in apolipoprotein E-deficient mice.	RLN1 RLN2	2.50e-05	3	101	2	27341752
Pubmed	Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis.	RLN1 RLN2	2.50e-05	3	101	2	17991721
Pubmed	Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis.	RLN1 RLN2	2.50e-05	3	101	2	17095590
Pubmed	Evidence of proteinuria, but no other characteristics of pre-eclampsia, in relaxin-deficient mice.	RLN1 RLN2	2.50e-05	3	101	2	27489037
Pubmed	Increased superoxide production and altered nitric oxide-mediated relaxation in the aorta of young but not old male relaxin-deficient mice.	RLN1 RLN2	2.50e-05	3	101	2	25957220
Pubmed	Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease.	RLN1 RLN2	2.50e-05	3	101	2	16254028
Pubmed	A vasoactive role for endogenous relaxin in mesenteric arteries of male mice.	RLN1 RLN2	2.50e-05	3	101	2	25243460
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	2.50e-05	3	101	2	11948212
Pubmed	The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs.	RLN1 RLN2	2.50e-05	3	101	2	16935837
Pubmed	Relaxin reverses airway remodeling and airway dysfunction in allergic airways disease.	RLN1 RLN2	2.50e-05	3	101	2	19213838
Pubmed	Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin.	RLN1 RLN2	2.50e-05	3	101	2	17425335
Pubmed	Relaxin is a key mediator of prostate growth and male reproductive tract development.	RLN1 RLN2	2.50e-05	3	101	2	12861045
Pubmed	Relaxin deficiency attenuates pregnancy-induced adaptation of the mesenteric artery to angiotensin II in mice.	RLN1 RLN2	2.50e-05	3	101	2	26936785
Pubmed	Enhanced uterine artery stiffness in aged pregnant relaxin mutant mice is reversed with exogenous relaxin treatment.	RLN1 RLN2	2.50e-05	3	101	2	23718984
Pubmed	Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.	RLN1 RLN2	2.50e-05	3	101	2	27488261
Pubmed	G protein beta gamma subunits. Simplified purification and properties of novel isoforms.	GNB1 GNB2	2.50e-05	3	101	2	8308009
Pubmed	Relaxin Deficiency Leads to Uterine Artery Dysfunction During Pregnancy in Mice.	RLN1 RLN2	2.50e-05	3	101	2	29623045
Pubmed	Physical fitness, serum relaxin and duration of gestation.	RLN1 RLN2	2.50e-05	3	101	2	26272327
Pubmed	Cardiomyocyte-specific RXFP1 overexpression protects against pressure overload-induced cardiac dysfunction independently of relaxin.	RLN1 RLN2	2.50e-05	3	101	2	38768763
Pubmed	Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype.	RLN1 RLN2	2.50e-05	3	101	2	12566112
Pubmed	Relaxin plays an important role in the regulation of airway structure and function.	RLN1 RLN2	2.50e-05	3	101	2	17584966
Pubmed	Collagen studies in late pregnant relaxin null mice.	RLN1 RLN2	2.50e-05	3	101	2	10952910
Pubmed	Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal transition via the Wnt/β-catenin signaling pathway.	RLN1 RLN2	2.50e-05	3	101	2	35311469
Pubmed	Molecular remodeling of members of the relaxin family during primate evolution.	RLN1 RLN2	2.50e-05	3	101	2	11230540
Pubmed	KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.	SEH1L SZT2 MIOS	2.61e-05	20	101	3	28199306
Pubmed	Integral and associated lysosomal membrane proteins.	WDR11 MIOS GNB4 GNB1 GNB2	3.46e-05	126	101	5	17897319
Interaction	SEMA6A interactions	SORBS2 SORBS1 PTCH1 RLN1 SEMA6A NCK2	5.12e-07	63	95	6	int:SEMA6A
Interaction	RGS6 interactions	GNB5 GNB4 GNB1 GNB2	1.35e-06	18	95	4	int:RGS6
Interaction	GNG7 interactions	GNB5 GNB4 GNB1 GNB2	2.12e-06	20	95	4	int:GNG7
Interaction	GNG3 interactions	GNB5 GNB4 GNB1 GNB2	4.58e-06	24	95	4	int:GNG3
Interaction	GNG4 interactions	GNB5 GNB4 GNB1 GNB2	5.43e-06	25	95	4	int:GNG4
Interaction	GNGT1 interactions	GNB5 GNB4 GNB1 GNB2	6.40e-06	26	95	4	int:GNGT1
Interaction	GNGT2 interactions	GNB4 GNB1 GNB2	2.16e-05	12	95	3	int:GNGT2
Interaction	GNG13 interactions	GNB5 GNB4 GNB1 GNB2	4.11e-05	41	95	4	int:GNG13
Interaction	GNG11 interactions	GNB4 GNB1 GNB2	6.58e-05	17	95	3	int:GNG11
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	7.60e-05	37	101	3	16p12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB4 NPIPB3 NPIPB5 KATNIP	5.85e-04	172	101	4	chr16p12
Cytoband	2p25	TPO KLF11	7.17e-04	18	101	2	2p25
Cytoband	16p11.2	NPIPB12 NPIPB11 NPIPB13 KIF22	8.65e-04	191	101	4	16p11.2
Cytoband	2q24.2	KCNH7 MAP3K20	1.08e-03	22	101	2	2q24.2
Cytoband	13q12	FLT3 GPR12	1.28e-03	24	101	2	13q12
Cytoband	2q34	FN1 CRYGB	1.75e-03	28	101	2	2q34
Cytoband	17q23.3	CEP95 SCN4A	2.00e-03	30	101	2	17q23.3
Cytoband	9p24.1	RLN1 RLN2	2.57e-03	34	101	2	9p24.1
Cytoband	Ensembl 112 genes in cytogenetic band chr16p11	NPIPB12 NPIPB11 NPIPB13 KIF22	3.39e-03	278	101	4	chr16p11
GeneFamily	WD repeat domain containing	SEH1L TBL3 WDR11 GNB5 GNB4 IFT122 DCAF11 GNB1 GNB2	5.74e-07	262	68	9	362
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL10RA IL1RAPL2 IL1RAP	5.26e-04	42	68	3	602
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL7 OSBPL8	8.98e-04	12	68	2	670
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	TPO CSMD2 SRPX	1.29e-03	57	68	3	1179
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL1RAPL2 IL1RAP	1.42e-03	15	68	2	1296
GeneFamily	Lipocalins	AMBP LCN6	2.29e-03	19	68	2	631
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA5A SEMA6A	2.53e-03	20	68	2	736
GeneFamily	Fibrinogen C domain containing	ITLN2 ANGPTL4	3.95e-03	25	68	2	554
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KCNH7 GRIK5 CSMD2 ELAPOR1 RIMS2	4.17e-05	169	101	5	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SORBS2 MAP3K20 GRIK5 SCN4A COX4I2	5.20e-05	177	101	5	d731400997afea379f47ae8aa0f82802962b0861
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	SEH1L GATAD2A NPIPB11 ADCK1 WDR11	5.34e-05	178	101	5	536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCHIP1 ANGPTL4 GNB4 COX4I2 NCK2	5.48e-05	179	101	5	f5bb4d3a27d56698473219970e764084096cc582
ToppCell	facs-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCHIP1 PTCH1 ANGPTL4 COX4I2 NCK2	5.48e-05	179	101	5	7078022e60faa86444f2a2c6eb9f767cc66b5cfa
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCHIP1 ANGPTL4 GNB4 COX4I2 NCK2	5.48e-05	179	101	5	fa03ec3cc0132f977b4cb28e7b23789732375183
ToppCell	facs-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCHIP1 PTCH1 ANGPTL4 COX4I2 NCK2	5.48e-05	179	101	5	d4a975d8ffa5e77fb5c0ec05bf9c8f843c77ce07
ToppCell	droplet-Limb_Muscle-Pre-Sort\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 MAP3K20 SORBS1 COX4I2 GNB1	5.63e-05	180	101	5	af2bafcd1b2082629de3ea336711add01565c4c4
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCHIP1 ANGPTL4 GNB4 COX4I2 NCK2	5.63e-05	180	101	5	f6a05b3751b01e74b2de8440801b0eb2e723c199
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCHIP1 ANGPTL4 GNB4 COX4I2 NCK2	5.63e-05	180	101	5	dfc75ae4395ff46fbec2c54915d98ead5a1ba1a1
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 MAP3K20 SORBS1 COX4I2 GNB1	5.63e-05	180	101	5	f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SORBS2 MAP3K20 PP2D1 ANGPTL4 COX4I2	5.93e-05	182	101	5	97bb07478f56a937b490fba121ee603db64134a1
ToppCell	droplet-Tongue-nan-24m-Myeloid-Langerhans_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL10RA FLT3 DNAH2 ALPK2 GSG1	5.93e-05	182	101	5	0f06309318c064f0ebdb12a46226b90032290137
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 MAP3K20 SORBS1 PTCH1 NLRP5	5.93e-05	182	101	5	728a2152c166551ac229370c0900fe2bc426ea9b
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SORBS2 MAP3K20 PP2D1 ANGPTL4 COX4I2	5.93e-05	182	101	5	1c1a687f728341c209b048b6715bcddd0ac20069
ToppCell	facs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 MAP3K20 SEMA5A LHFPL5 COX4I2	6.09e-05	183	101	5	8d45dff06a199b1369576657f7f9dc0249c5f841
ToppCell	facs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 MAP3K20 SEMA5A LHFPL5 COX4I2	6.09e-05	183	101	5	421265fa15d5a028cb567bb0904e670473ef102b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CSMD2 IL1RAPL2 ELAPOR1 IL1RAP UTRN	6.41e-05	185	101	5	5a0340c25196453f19e424d346efbf66d2c53ac3
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	SORBS2 FN1 SEMA5A GNB4 KIF22	7.27e-05	190	101	5	d2afa08ad868acc6fce308ec21b0bf93591d4010
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMBP KCNH7 ELAPOR1 RIMS2 GSG1	7.64e-05	192	101	5	5692bd57093852d442400383850f416c497dcc7d
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NPIPB4 NPIPB3 NPIPB5 CD163L1 UTRN	7.82e-05	193	101	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NPIPB4 ENPP3 SYNE1 NPIPB5 UTRN	7.82e-05	193	101	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FN1 DYNLT3 CD163L1 COX4I2 MICOS10	8.02e-05	194	101	5	b8aa48d7774e4da3351ee2177eb694fcfec7cbc3
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 MAP3K20 SORBS1 GNB4 COX4I2	8.02e-05	194	101	5	b8a130ffae68ffe550bf335460a1ec1035cf8d8d
ToppCell	facs-Brain_Non-Myeloid\|facs / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 SYNE1 SORBS1 SEMA6A UTRN	8.62e-05	197	101	5	a1f7eec1aca03432caa8fe817ff6d24b29d4062d
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NPIPB4 ENPP3 SYNE1 NPIPB5 UTRN	8.62e-05	197	101	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 SYNE1 MAP3K20 SORBS1 UTRN	8.62e-05	197	101	5	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FN1 SYNE1 SEMA5A PTCH1 SRPX	9.04e-05	199	101	5	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SYNE1 MAP3K20 ADAMTS13 PTCH1 GNB5	9.04e-05	199	101	5	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	Sepsis-URO-Lymphocyte-T/NK-CD8+_Tcm\|URO / Disease, condition lineage and cell class	SEMA5A RLN2 ELAPOR1 RIMS2 NCK2	9.04e-05	199	101	5	eb085f9f2c837494548c26bb61e8b74516539e23
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SORBS2 SEMA5A CSMD2 RIMS2 IL1RAP	9.25e-05	200	101	5	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SORBS2 SEMA5A CSMD2 RIMS2 IL1RAP	9.25e-05	200	101	5	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SORBS2 SEMA5A CSMD2 RIMS2 IL1RAP	9.25e-05	200	101	5	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SORBS2 SEMA5A CSMD2 RIMS2 IL1RAP	9.25e-05	200	101	5	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SORBS2 SEMA5A CSMD2 RIMS2 IL1RAP	9.25e-05	200	101	5	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SORBS2 SEMA5A CSMD2 RIMS2 IL1RAP	9.25e-05	200	101	5	961858738ce35db8760c8c2e136f8369bc444ccf
Disease	calcium oxalate nephrolithiasis (biomarker_via_orthology)	AMBP FN1	3.01e-05	3	94	2	DOID:0080652 (biomarker_via_orthology)
Disease	Acute lymphoid leukemia	FLT3 GNB1	2.78e-04	8	94	2	cv:C0023449
Disease	LEUKEMIA, ACUTE LYMPHOBLASTIC	FLT3 GNB1	2.78e-04	8	94	2	613065
Disease	worry measurement	KLF11 PTCH1 UTP25 SCAI	1.51e-03	154	94	4	EFO_0009589
Disease	anorectal malformation	CSMD2 KLHL17	1.66e-03	19	94	2	MONDO_0019938
Disease	autoimmune disease	TPO FLT3 KCNH7 NEURL4	2.31e-03	173	94	4	EFO_0005140

Protein segments in the cluster

Peptide	Gene	Start	Entry
TIKQGSRCDRWMVLG	UMODL1-AS1	101	Q8N2C9
MTSTRWRKGVCEETS	AMBP	81	P02760
CMLTARSWDSVNRGI	ADCK1	386	Q86TW2
CKMTSDGGWTVIQRR	ANGPTL4	216	Q9BY76
SLMGDCARWELSEKR	ARSL	176	P51690
VGSRVRECMANGLWS	CSMD2	2691	Q7Z408
RECMANGLWSGSEVR	CSMD2	2696	Q7Z408
MQSRAWGKVEVRPSC	CXorf49;	286	A8MYA2
SGMSQCWETAADKRV	ALPK2	506	Q86TB3
DVACRRIAWGKFMNS	ALDH3A1	226	P30838
CRDSEGSMRESGVWI	GJA10	406	Q969M2
RSFRSGMWLSCEETV	GSG1	91	Q2KHT4
VMGWNCLRDESTCSV	GPR12	176	P47775
GTIWLDDMRCKGNES	CD163L1	1306	Q9NR16
MNSIRDCFVTGKWED	BMS1	751	Q14692
WMECSVSCGDGIQRR	ADAMTS13	1081	Q76LX8
SARKALCNWVRMAAA	NPIPB3	206	Q92617
RAQIAICGMSTWSKR	RLN2	41	P04090
ICGMSTWSKRSLSQE	RLN2	46	P04090
MDWCKDKRRIVSSSQ	GNB5	111	O14775
SARKALCNWVRMAAA	NPIPB12	206	F8W0I5
CRWREEKSGAIMCEN	GATAD2A	426	Q86YP4
SNVWDGDRECSGMKL	MINDY3	231	Q9H8M7
CLSFSGVKEREWQME	IFT122	456	Q9HBG6
SRVTVMEKCSDGWWR	NCK2	136	O43639
SLTTQTCGAWEMKER	IKBKB	6	O14920
SERCDDWGLDTMRQI	IL1RAP	21	Q9NPH3
CKDITDMRSWERENA	KCNH7	986	Q9NS40
MDGQTLRKAERSWSC	KATNIP	1	O60303
GDGWLKSFQRSRRMC	ATXN8OS	86	P0DMR3
CQPNADDSRWMKTTE	ELAPOR1	211	Q6UXG2
GWDSSEVRRMCGEQT	LHFPL5	151	Q8TAF8
SETAERLGRGCMWDV	BNIPL	156	Q7Z465
LTSNMWRVRESSCLA	ECPAS	1171	Q5VYK3
MKASSGRCGLVRWLQ	PCDHGB2	1	Q9Y5G2
VRGMDSCSLEIANWR	KIF22	66	Q14807
CDSITGMNLEAWRET	TPO	721	P07202
GGDDAICKVWDRRTM	DCAF11	326	Q8TEB1
CDQSVMDLIKRNSGW	LCN6	81	P62502
SARKALCNWVRMAAA	NPIPB5	206	A8MRT5
ASIKLWDVRDSMCRQ	GNB2	206	P62879
ASSKLWDIRDGMCRQ	GNB4	206	Q9HAV0
SRSNKGMWSKEECIS	IL10RA	211	Q13651
FCRMAVEGVWNRKSV	NLRP5	531	P59047
SWEARTTNLRMDCRK	NOL8	1141	Q76FK4
SARKALCNWVRMAAA	NPIPB4	206	C9JG80
WMRLCTSATESEVAR	UQCRC1	376	P31930
SARKALCNWVRMAAA	NPIPB11	206	E5RHQ5
RATSESDGRCWMDAL	OSBPL8	246	Q9BZF1
GGRVSLRSNKVMWVC	RIMS2	151	Q9UQ26
IMQSCWAFDSRKRPS	FLT3	921	P36888
SWEVVTSMGTQRCDA	KLHL12	546	Q53G59
TNKWVAASCMFTRRS	KLHL17	601	Q6TDP4
ASAKLWDVREGMCRQ	GNB1	206	P62873
ITMKNCARAWRELSE	LINC00473	81	A8K010
ESTRIWMCNKFRCGE	ENPP3	91	O14638
SEGRRDNMKWCGTTQ	FN1	436	P02751
DMLKESCRIASSVNW	FOXJ3	461	Q9UPW0
AKWQRLAMEGSTCLD	CYP4F8	176	P98187
AGKTIREWMRENCCN	FAM172A	331	Q8WUF8
WMIGSREERNIRSCD	CEP350	166	Q5VT06
WKRVSFGRCSLSSEM	CEP95	151	Q96GE4
SRCNSIRVESGCWMI	CRYGB	31	P07316
DSSADCQWLDTLRMR	MAP3K20	566	Q9NYL2
DMRGKCTVGDRWSSQ	ITLN2	101	Q8WWU7
DGTCTVRWENRTMNC	DYNLT3	91	P51808
LVCMSSWGQRSQKGD	KLF11	51	O14901
VRSLNMSWRENCEAS	GRIK5	281	Q16478
WRNRCMDLSGISKQL	DNAH2	281	Q9P225
WREACDTGSSRMDRK	DYNAP	16	Q8N1N2
SGNDKECCNDMTVWR	RNASE11	91	Q8TAA1
MTVWRKVSEANGSCK	RNASE11	101	Q8TAA1
RMATCSSDQSVKVWD	SEH1L	26	Q96EE3
NRRSNEWKTVMGCVF	COX4I2	96	Q96KJ9
TWMVSSCEVRRDGQL	NEURL4	1006	Q96JN8
RTETMRSCTVEAVRW	CROT	451	Q9UKG9
RSCTVEAVRWCQSMQ	CROT	456	Q9UKG9
SARKALCNWVRMAAA	NPIPB13	206	A6NJU9
KRTSRMWCTQSFAKD	OSBPL7	246	Q9BZF2
MSESELGRKWDRCLA	MICOS10	1	Q5TGZ0
RRSFWDMLSKTECGD	SZT2	2441	Q5T011
CNMLRATNRGEEATW	UTP25	701	Q68CQ4
SESLRTVNMTWNKIC	UTRN	2161	P46939
KSECESLMHTGQVRW	SCN4A	1206	P35499
QMRCKELENAVGSWT	SYNE1	7711	Q8NF91
RAQIAICGMSTWSKR	RLN1	41	P04808
ICGMSTWSKRSLSQE	RLN1	46	P04808
MERSGQRVTTWDCDQ	SCHIP1	1	P0DPB3
MVSKRNSVDGCIDWS	IL1RAPL2	21	Q9NP60
TMLRWDCSKSQGAVG	PTCH1	456	Q13635
ERTVTCMDNKAWSGR	SRPX	156	P78539
MEKCDDGWFVGTSRR	SORBS2	1071	O94875
DTWTTFMKARLNCSR	SEMA5A	266	Q13591
AKILNMSSGRCWSSD	HIBADH	241	P31937
DNKTWAESERNCSGM	CLEC4D	101	Q8WXI8
DEKNSLWREMCSTLR	MIOS	566	Q9NXC5
FASCAKDQSVRIWRM	TBL3	391	Q12788
RNLNMETTRTRCWKD	TRIM51	156	Q9BSJ1
TWKSRQADVDTCRMK	SEMA6A	96	Q9H2E6
MEKCDDGWFVGTSRR	SORBS1	1261	Q9BX66
ACRGEVTWDCMKTQL	TMEM214	646	Q6NUQ4
GLSSMRRGLWEKCQE	SCAI	491	Q8N9R8
RMSLASCGTDWDIVR	DHX38	1056	Q92620
MTHDKSWRRCSISGS	TPRXL	1	Q17RH7
SARKALCNWVRMAAA	NPIPB2	221	A6NJ64
CSMSGRAWVSREELE	nan	256	A6NJR5
MIWELKSAVCNRNSR	WDR11	381	Q9BZH6
VGICEDRNSTWKADM	PP2D1	171	A8MPX8
ADMCTNARRVVRKSW	NACC1	461	Q96RE7