Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	2.21e-12	37	83	8	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	2.79e-12	38	83	8	GO:0070001
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 CPEB3 ERVK-7 ERVK-10	2.12e-08	21	83	5	GO:0035613
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	8.96e-08	11	83	4	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	2.69e-07	14	83	4	GO:0003964
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 FURIN ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 MMP15 CAPN15	1.63e-06	430	83	11	GO:0004175
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.65e-05	37	83	4	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.84e-05	38	83	4	GO:0034061
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10	3.96e-05	46	83	4	GO:0016893
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 ZGLP1 ERVK-8 MYRIP ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 MORC2 MMP15 CXXC1	7.44e-05	891	83	13	GO:0008270
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 FURIN ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 MMP15 CAPN15	8.11e-05	654	83	11	GO:0008233
GeneOntologyMolecularFunction	structural molecule activity	ERVK-6 ERVK-8 DNM3 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 POM121C MOBP CLDN2	3.03e-04	891	83	12	GO:0005198
GeneOntologyMolecularFunction	SH3 domain binding	MAPK15 WAS EFS SYNJ2 NCKIPSD	3.26e-04	143	83	5	GO:0017124
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	3.29e-04	79	83	4	GO:0004521
GeneOntologyMolecularFunction	transition metal ion binding	XYLT2 ERVK-6 ZGLP1 ERVK-8 MYRIP ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 MORC2 MMP15 CXXC1	3.63e-04	1189	83	14	GO:0046914
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	2.50e-03	136	83	4	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	2.50e-03	136	83	4	GO:0004519
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.54e-07	13	81	4	GO:0015074
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 SH3PXD2A ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.04e-06	85	81	6	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 SH3PXD2A ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.04e-06	85	81	6	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 SH3PXD2A ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.36e-06	89	81	6	GO:0006949
GeneOntologyBiologicalProcess	viral process	ERVK-6 FURIN ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 MORC2 PAIP1	1.95e-06	464	81	11	GO:0016032
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 MAPK15 ERVK-8 ERVK-7 ERVK-10	1.88e-05	83	81	5	GO:0006278
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7 ERVK-10	3.77e-05	48	81	4	GO:0000731
GeneOntologyBiologicalProcess	DNA-templated DNA replication	ERVK-6 WIZ ERVK-8 ERVK-7 ERVK-10 MCM10	7.21e-05	178	81	6	GO:0006261
GeneOntologyBiologicalProcess	DNA replication	ERVK-6 MAPK15 WIZ ERVK-8 ERVK-7 ERVK-10 MCM10	2.26e-04	312	81	7	GO:0006260
Domain	SH3	ARHGAP32 EFS SH3PXD2A NCKIPSD TNK2 MYO15A PPP1R13L DNMBP	1.28e-06	216	69	8	SM00326
Domain	SH3	ARHGAP32 EFS SH3PXD2A NCKIPSD TNK2 MYO15A PPP1R13L DNMBP	1.28e-06	216	69	8	PS50002
Domain	SH3_domain	ARHGAP32 EFS SH3PXD2A NCKIPSD TNK2 MYO15A PPP1R13L DNMBP	1.47e-06	220	69	8	IPR001452
Domain	SH3_1	ARHGAP32 EFS SH3PXD2A NCKIPSD TNK2 PPP1R13L DNMBP	2.42e-06	164	69	7	PF00018
Domain	SH3_9	ARHGAP32 EFS TNK2 PPP1R13L DNMBP	1.02e-05	78	69	5	PF14604
Domain	CRIB	WAS PAK4 TNK2	5.26e-05	20	69	3	PS50108
Domain	CRIB_dom	WAS PAK4 TNK2	6.12e-05	21	69	3	IPR000095
Domain	WASP_C	WAS PAK4	2.79e-04	7	69	2	IPR011026
Domain	FYVE_2	MYRIP MOBP	7.24e-04	11	69	2	PF02318
Domain	-	WAS PAK4	8.67e-04	12	69	2	3.90.810.10
Domain	PBD	WAS PAK4	1.56e-03	16	69	2	SM00285
Domain	PBD	WAS PAK4	1.76e-03	17	69	2	PF00786
Domain	Znf_FYVE_PHD	TAF3 MYRIP CXXC1 MOBP	2.14e-03	147	69	4	IPR011011
Domain	SANT_dom	NCOR2 RCOR3	4.13e-03	26	69	2	IPR017884
Domain	SANT	NCOR2 RCOR3	4.78e-03	28	69	2	PS51293
Domain	MAGE	MAGED1 MAGED4	6.99e-03	34	69	2	SM01373
Domain	Myb_DNA-binding	NCOR2 RCOR3	7.40e-03	35	69	2	PF00249
Domain	MAGE	MAGED1 MAGED4	7.81e-03	36	69	2	PS50838
Domain	MAGE	MAGED1 MAGED4	7.81e-03	36	69	2	PF01454
Domain	MHD_dom	MAGED1 MAGED4	7.81e-03	36	69	2	IPR002190
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10 ERVK-24	3.17e-11	4	84	4	10469592
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	5.69e-11	12	84	5	14557543
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	7.74e-11	94	84	8	21542922
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-7 ERVK-21	1.58e-10	5	84	4	12629516
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19 ERVK-10	5.43e-08	4	84	3	7983737
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TRPM4 NCOR2 TBKBP1 ZNF48 WIZ CELSR3 BICRA FURIN AKNA TNK2 MBD6 POM121C DNMBP PLEKHG5 KIFC2	5.89e-08	1105	84	15	35748872
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9 ERVK-10 ERVK-24	9.44e-08	18	84	4	18664271
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	CELSR3 EFS SYNJ2 BICRA NCKIPSD MYRIP DNM3 KIFC2 GABBR1	1.07e-07	329	84	9	17474147
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	SLAIN2 IRF2BP1 SYNJ2 KATNB1 FAM83G SRRM2	2.60e-07	108	84	6	19531213
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	2.70e-07	6	84	3	15063128
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	1.61e-06	10	84	3	12970426
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	ARHGAP32 SYNJ2 PAK4 MARK2 SRRM2	5.05e-06	102	84	5	15778465
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SLAIN2 CELSR3 SYNJ2 RNF44 PAK4 AKNA HHIPL1 DNMBP PLEKHG5	5.45e-06	529	84	9	14621295
Pubmed	Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.	WAS TNK2	5.76e-06	2	84	2	16257963
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	5.76e-06	2	84	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	5.76e-06	2	84	2	9460924
Pubmed	Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.	SH3PXD2A NCKIPSD MYO15A DNMBP	6.70e-06	50	84	4	19807924
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SLAIN2 FSIP2 ARHGAP32 SYNJ2 SH3PXD2A PAK4 NCKIPSD FAM83G MARK2 SRRM2 DNMBP	7.20e-06	861	84	11	36931259
Pubmed	A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK.	WAS TNK2	1.73e-05	3	84	2	28539360
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	1.73e-05	3	84	2	10516026
Pubmed	Analysis of PPARGC1B, RUNX3 and TBKBP1 polymorphisms in Chinese Han patients with ankylosing spondylitis: a case-control study.	PPARGC1B TBKBP1	1.73e-05	3	84	2	23637848
Pubmed	Analysis of clinical indexes and RUNX3, TBKBP1, PPARGC1B polymorphisms in Chinese Han patients with ankylosing spondylitis.	PPARGC1B TBKBP1	1.73e-05	3	84	2	25494292
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	1.73e-05	3	84	2	9971820
Pubmed	Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors.	ROBO4 WAS	1.73e-05	3	84	2	18948384
Pubmed	Interaction network of human early embryonic transcription factors.	NCOR2 TAF3 TBKBP1 WIZ BICRA MBD6 POM121C	2.34e-05	351	84	7	38297188
Pubmed	A human MAP kinase interactome.	ARHGAP32 WAS SYNJ2 BICRA PAK4 SREBF2 TNK2 POM121C	2.36e-05	486	84	8	20936779
Pubmed	CPEB2-eEF2 interaction impedes HIF-1α RNA translation.	CPEB3 GABBR1 CAPN15	2.65e-05	24	84	3	22157746
Pubmed	Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.	WAS TNK2	3.45e-05	4	84	2	10360579
Pubmed	GLTSCR1, ATM, PPP1R13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population.	BICRA PPP1R13L	3.45e-05	4	84	2	30128886
Pubmed	Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct.	ARHGAP32 TNK2	3.45e-05	4	84	2	18477472
Pubmed	Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.	WAS TNK2	3.45e-05	4	84	2	36178070
Pubmed	Human transcription factor protein interaction networks.	NCOR2 ARHGAP32 TAF3 MAGED1 WIZ IRF2BP1 BICRA RCOR3 MBD6 MORC2 SRRM2 POM121C CXXC1	3.73e-05	1429	84	13	35140242
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TRPM4 NCOR2 MAGED1 EFS KATNB1 NCKIPSD SMO POM121C GABBR1	4.78e-05	697	84	9	28298427
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	NCOR2 IRF2BP1 RCOR3	5.26e-05	30	84	3	26593974
Pubmed	Structure of Cdc42 bound to the GTPase binding domain of PAK.	WAS TNK2	5.74e-05	5	84	2	10802735
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	5.74e-05	5	84	2	11401426
Pubmed	Residues in Cdc42 that specify binding to individual CRIB effector proteins.	WAS TNK2	5.74e-05	5	84	2	10684602
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NCOR2 ARHGAP32 MAGED1 BICRA TNK2 POM121C PAIP1	8.40e-05	430	84	7	35044719
Pubmed	Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion.	WAS NCKIPSD	8.59e-05	6	84	2	14559906
Pubmed	Novel interaction partners of the CD2BP2-GYF domain.	MAGED1 AKNA	1.60e-04	8	84	2	16000308
Pubmed	Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.	NCOR2 WIZ RCOR3	1.79e-04	45	84	3	21258344
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TRPM4 NCOR2 PPARGC1B TBKBP1 SYNJ2 SH3PXD2A BICRA SREBF2 MYRIP TNK2 RCOR3 TMEM181	2.37e-04	1489	84	12	28611215
Pubmed	Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.	SH3PXD2A NCKIPSD DNMBP	3.43e-04	56	84	3	22745667
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SLAIN2 NCOR2 TAF3 WIZ BICRA HRES1 RCOR3 C16orf96 SRRM2 POM121C	3.57e-04	1116	84	10	31753913
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MAGED1 WIZ SYNJ2 SH3PXD2A PAK4 C16orf96 MORC2 DNMBP	3.68e-04	724	84	8	36232890
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	SLAIN2 ARHGAP32 MAGED1 SH3PXD2A PAK4 DNM3 PPP1R13L DNMBP PLEKHG5	3.70e-04	916	84	9	32203420
Pubmed	Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).	MAGED1 MAGED4	3.75e-04	12	84	2	22544753
Pubmed	Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid.	PPARGC1B SREBF2	4.42e-04	13	84	2	32266253
Pubmed	Cdc42 activation by endothelin regulates neural crest cell migration in the cardiac outflow tract.	WAS TNK2	4.42e-04	13	84	2	31219639
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	NCOR2 MAGED1 BICRA MCM10	5.16e-04	152	84	4	38360978
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	SLAIN2 WIZ IRF2BP1 PAK4 KATNB1 MARK2 MCM10 POM121C CXXC1	7.29e-04	1007	84	9	34597346
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	TBKBP1 MAGED1 SH3PXD2A PAK4 NCKIPSD MARK2	7.52e-04	446	84	6	24255178
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	DNMBP PLEKHG5	8.60e-04	18	84	2	12799088
Pubmed	Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.	WIZ EGR4	9.60e-04	19	84	2	30385546
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	NCOR2 ARHGAP32 MARK2 POM121C	9.70e-04	180	84	4	35198878
Pubmed	Bioinformatics and cellular signaling.	WAS EFS SREBF2 BANK1	1.01e-03	182	84	4	15102471
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	SLAIN2 ARHGAP32 TBKBP1 SYNJ2 KATNB1 FAM83G DNMBP PAIP1	1.07e-03	853	84	8	28718761
Pubmed	Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene.	SLAIN2 MARK2	1.29e-03	22	84	2	22305495
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	SH3PXD2A CPEB3 MARK2 SRRM2 GABBR1	1.56e-03	347	84	5	17114649
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	NCOR2 MAPK15 TBKBP1 SH3PXD2A PAK4 DNM3 TNK2 MARK2	1.61e-03	910	84	8	36736316
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ARHGAP32 TBKBP1 PLEKHG5	1.91e-03	101	84	3	9872452
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	SLAIN2 SH3PXD2A DNM3	2.02e-03	103	84	3	21706016
Pubmed	An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.	BICRA SRRM2	2.24e-03	29	84	2	19279220
Pubmed	The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.	SRRM2 POM121C	2.24e-03	29	84	2	17577209
Interaction	HNF4A interactions	NCOR2 PPARGC1B TAF3 WIZ IRF2BP1 BICRA SREBF2 RCOR3 MORC2 CXXC1	1.06e-07	275	78	10	int:HNF4A
Interaction	B4GALT2 interactions	NCOR2 ARHGAP32 MAGED1 PPP1R13L POM121C DNMBP	6.78e-06	119	78	6	int:B4GALT2
Interaction	NCK2 interactions	KIAA0408 ARHGAP32 WAS EFS NCKIPSD TNK2 MBD6 INCA1	7.84e-06	262	78	8	int:NCK2
Interaction	MAPRE3 interactions	SLAIN2 SYNJ2 FAM161B MARK2 MCM10 PPP1R13L DNMBP	3.06e-05	230	78	7	int:MAPRE3
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_4\|356C / Donor, Lineage, Cell class and subclass (all cells)	FSIP2 CELSR3 FAM83G INCA1 PLEKHG5	6.07e-06	153	75	5	cda759ab83a271974651fe4faa21ed4f7ecbb3ae
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZGLP1 SH3PXD2A KCTD14 AKNA BANK1	8.76e-06	165	75	5	22293c6b55f44636440cd737efb786ff5de3373d
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2A SREBF2 FAM83G MCM10 CLDN2	1.13e-05	174	75	5	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; HL60; HT_HG-U133A	XYLT2 ARHGAP32 CELSR3 SH3PXD2A PAK4 DNM3 BANK1	3.64e-06	192	76	7	2703_DN
Drug	Cesead Opaque Primer	ROBO4 ARHGAP32	3.29e-05	3	76	2	CID000135071
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	ARHGAP32 SYNJ2 MCM10 DNMBP CXXC1 CAPN15	4.08e-05	189	76	6	1651_DN
Drug	Dinoprost trometamol [38362-01-5]; Up 200; 8.4uM; PC3; HT_HG-U133A	TBKBP1 WAS CELSR3 SYNJ2 KCTD14 DNM3	4.72e-05	194	76	6	6308_UP
Drug	Debrisoquin sulfate [581-88-4]; Up 200; 9uM; MCF7; HT_HG-U133A	NCOR2 IRF2BP1 SYNJ2 MARK2 MORC2 SRRM2	5.00e-05	196	76	6	5288_UP
Drug	Naphazoline hydrochloride [550-99-2]; Up 200; 16.2uM; PC3; HG-U133A	ROBO4 IRF2BP1 EGR4 BICRA SREBF2 CAPN15	5.00e-05	196	76	6	1886_UP
Drug	Hesperidin [520-26-3]; Down 200; 6.6uM; HL60; HT_HG-U133A	SYNJ2 FURIN PAK4 SREBF2 TNK2 CAPN15	5.00e-05	196	76	6	1294_DN
Drug	Meclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A	XYLT2 TRPM4 IRF2BP1 FURIN SRRM2 CAPN15	5.14e-05	197	76	6	5244_DN
Drug	2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A	XYLT2 TRPM4 BICRA NCKIPSD MARK2 CAPN15	5.14e-05	197	76	6	6974_DN
Drug	Ketotifen fumarate [34580-14-8]; Down 200; 9.4uM; MCF7; HT_HG-U133A	WIZ IRF2BP1 SYNJ2 SREBF2 PPP1R13L MMP15	5.29e-05	198	76	6	7199_DN
Drug	Spironolactone [52-01-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	WIZ IRF2BP1 SYNJ2 FURIN KATNB1 SRRM2	5.29e-05	198	76	6	2226_DN
Drug	Sulfinpyrazone [57-96-5]; Up 200; 9.8uM; MCF7; HT_HG-U133A	NCOR2 WIZ IRF2BP1 SREBF2 MMP15 CXXC1	5.29e-05	198	76	6	6230_UP
Drug	Isoxsuprine hydrochloride [579-56-6]; Up 200; 11.8uM; HL60; HG-U133A	XYLT2 NCOR2 WAS EFS BICRA FURIN	5.29e-05	198	76	6	1985_UP
Drug	Nicergoline; Down 200; 8.2uM; MCF7; HT_HG-U133A	TRPM4 WIZ IRF2BP1 MARK2 MMP15 CXXC1	5.44e-05	199	76	6	2220_DN
Drug	Proadifen hydrochloride [62-68-0]; Down 200; 10.2uM; MCF7; HT_HG-U133A	WIZ IRF2BP1 SREBF2 RCOR3 MARK2 CAPN15	5.59e-05	200	76	6	7165_DN
Disease	Alzheimer disease, polygenic risk score	FSIP2 NCKIPSD SREBF2 CHSY3 PPP1R13L PAIP1 GABBR1	7.27e-04	586	75	7	EFO_0030082, MONDO_0004975
Disease	testosterone measurement	NCOR2 IRF2BP1 SH3PXD2A AKNA DNM3 C16orf96 HHIPL1 MYO15A DNMBP BANK1	1.41e-03	1275	75	10	EFO_0004908
Disease	visual epilepsy (biomarker_via_orthology)	SREBF2 SMO GABBR1	1.58e-03	90	75	3	DOID:11832 (biomarker_via_orthology)
Disease	aspartate aminotransferase measurement	NCOR2 AKNA MYO15A MMP15 POM121C DNMBP BANK1 GABBR1	2.08e-03	904	75	8	EFO_0004736
Disease	diastolic blood pressure, unipolar depression	FURIN BANK1	2.65e-03	30	75	2	EFO_0003761, EFO_0006336
Disease	aspartate aminotransferase to alanine aminotransferase ratio	AKNA DNM3 DNMBP KIFC2	3.25e-03	239	75	4	EFO_0010934
Disease	hepatocyte growth factor-like protein measurement	CELSR3 NCKIPSD	4.22e-03	38	75	2	EFO_0008154
Disease	non-melanoma skin carcinoma	PPARGC1B TAF3 MYO15A GABBR1	4.69e-03	265	75	4	EFO_0009260

Protein segments in the cluster

Peptide	Gene	Start	Entry
FIINRPPAPTPRPTS	BANK1	606	Q8NDB2
PRLRNPLERPSPPAQ	CCDC187	556	A0A096LP49
PSRPAPLPPSAQQRT	DNMBP	641	Q6XZF7
QSPTRALPRPLHPTP	TNK2	606	Q07912
IRPANSMPPRLNPRP	RCOR3	456	Q9P2K3
RSRREVPPQLQPPVP	CAPN15	246	O75808
NLTAPRPRTIPAPEP	CFAP99	191	D6REC4
TARPVLPRPPTISNP	NCOR2	1091	Q9Y618
QHPPLPPPSTLQGRR	MBD6	331	Q96DN6
PQTPRRSRPRAPAPV	MBD6	381	Q96DN6
NLRPSPNLRPSPNSR	MAGED1	441	Q9Y5V3
APRPPMAPRSQIPSR	MAGED4	386	Q96JG8
APTPRPARPTQQPGS	HHIPL1	636	Q96JK4
ARRPPAPQPAPRTLS	MYO15A	641	Q9UKN7
QLPSRTPVQGPRPRP	MAPK15	376	Q8TD08
QLRSRRHPPTPPEPS	GABBR1	921	Q9UBS5
QPTQPLPTVTPRRPG	MMP15	311	P51511
PLAQPLPNPSAPLRR	KATNB1	321	Q9BVA0
NSPRSGRPFPPINVP	FSIP2	981	Q5CZC0
SRRSPPPSPTTQRRP	DNM3	766	Q9UQ16
SRRPELPRPRSQAPP	KCNH4	846	Q9UQ05
LPRPRSQAPPTGTRP	KCNH4	851	Q9UQ05
RNETPPVPPPRSTSR	KIAA0408	261	Q6ZU52
NIPRPQTQPPSGSRP	FAM161B	141	Q96MY7
PRPPSRSQAQTPPRS	HRES1	21	P13985
VPSSSRQPPAQPPRT	MCM10	596	Q7L590
SPPPARPQAQRARPR	EGR4	81	Q05215
LPPSRRNSNSNPPLP	GPR101	376	Q96P66
LQRTHRTNRPLPPPP	ARHGAP32	1296	A7KAX9
RTNRPLPPPPSQRSA	ARHGAP32	1301	A7KAX9
PGFLQPPPLRQPRTT	PAIP1	51	Q9H074
VIRNAPSRPPSLPTP	MORC2	621	Q9Y6X9
SLPTPRPASQPRKAP	MORC2	631	Q9Y6X9
RPAPRSTPPSQPTHR	POM121C	156	A8CG34
PPAPRSPVTRAQPIT	ODAPH	51	Q17RF5
PPTRRLNPMAPPSRQ	ERVK-10	246	P87889
PPTRRLNPTAPPSRR	ERVK-19	246	Q9YNA8
PPTRRLNPTAPPSRQ	ERVK-21	246	P62683
PPTRRLNPTAPPSRQ	ERVK-24	246	P63145
PPTRRLNPTAPPSRQ	ERVK-6	246	Q7LDI9
PPTRRLNPTAPPSRQ	ERVK-7	246	P63130
PPTRRLNPTAPPSRQ	ERVK-8	246	P62685
PPTRRLNPTAPPSRQ	ERVK-9	246	P63126
PPTRRLNPTAPPSRQ	HERVK_113	246	P62684
SLPRPRRPLPTQQQP	CXXC1	231	Q9P0U4
GVLRPTQPQPSRAPP	C16orf96	411	A6NNT2
PPQQRRSPASPSQAP	CPEB3	186	Q8NE35
SSRESPPQQQPPRLP	FURIN	681	P09958
SPLNPQPRPTRQGRP	AKNA	316	Q7Z591
AQLLARSPPPPHRPR	EFS	281	O43281
PRPSTAPQRVPVASP	MARK2	556	Q7KZI7
QPLATRSSPRPGQPP	CLDN2	201	P57739
PQRQLSRDPLLPSRP	CELSR3	3176	Q9NYQ7
SRPPSRPQSVSRPPS	BICRA	801	Q9NZM4
RTQPLQPLPPLPSNR	C4orf54	1381	D6RIA3
PSSPQPRGAPRQRPI	PPP1R13L	356	Q8WUF5
LQGTQPAPRVRPPSP	KIFC2	141	Q96AC6
PPRAPSRNLAPTPRR	IRF2BP1	366	Q8IU81
PPGPRSPQREPQRVS	PAK4	286	O96013
SRSPPPRLPSQSLRP	INCA1	21	Q0VD86
PTPPPRRQLSAPHIT	FAM83G	641	A6ND36
PQTPVRPETPNRTPS	TAF3	331	Q5VWG9
RLPPERPQPQVLASP	RELL2	221	Q8NC24
PPRRSRSSSSPPPKQ	SRRM2	811	Q9UQ35
RFSPSPRNSPRPSPK	SLAIN2	341	Q9P270
PRNSPRPSPKQSPRN	SLAIN2	346	Q9P270
SPSRSLSVPNRPRPP	SYNJ2	1091	O15056
PRSRPRPPKDSQASP	PPARGC1B	371	Q86YN6
QPRSPPRSERQPRSP	MOBP	106	Q13875
QPRSPPRSERQPRSP	MOBP	116	Q13875
VRPVPSLVPRPPQTS	WIZ	1571	O95785
SQTPLPQSPRPRRPT	KCTD14	16	Q9BQ13
RAVRPRSPSPPRQTP	PROB1	386	E7EW31
PSSQIPPQPRRAAPT	NCKIPSD	166	Q9NZQ3
PPTRRLNPTAPPSRQ	ERVK-9	246	P63128
RPSPQVPAVRRLPPQ	ROBO4	596	Q8WZ75
PQSRPRQEQSPPPAR	CHSY3	66	Q70JA7
SPPPSPRLRRRTPVQ	PLEKHG5	851	O94827
QPPRPVVPRRQPSRA	ZNF48	246	Q96MX3
AAPERSPQPRLPPSR	TYMSOS	76	Q8TAI1
PPPRSRPARQQPDPQ	TMEM181	56	Q9P2C4
RAQISSPNLRTRPPP	SH3PXD2A	416	Q5TCZ1
PPARDERLPSQQPPS	RNF44	46	Q7L0R7
ERLPSQQPPSRPPHL	RNF44	51	Q7L0R7
VPTTPRATPILQPRP	SREBF2	121	Q12772
RQSGDRRQLPPPPTP	WAS	151	P42768
RRQLPPPPTPANEER	WAS	156	P42768
PAPSTIPRLPQLPRQ	SMO	696	Q99835
ARPATAQPPRSLLPP	nan	41	Q8IYB0
VPPPRNSRAPPRLTV	TAPR1	151	Q14CZ0
APRLQPSRTSPQAPR	PVRIG	201	Q6DKI7
RSPVPPCPSPQQRRS	TBKBP1	371	A7MCY6
PQRRSPVPPSCQSPS	TBKBP1	396	A7MCY6
PVPPSCQSPSPQRRS	TBKBP1	401	A7MCY6
CQSPSPQRRSPVPPS	TBKBP1	406	A7MCY6
RRLQPPGTPSAPPQR	ZGLP1	111	P0C6A0
PGTPSAPPQRRPRKQ	ZGLP1	116	P0C6A0
SRQRASRRVPPAPPP	XYLT2	101	Q9H1B5
QLCRRPRSPQPSSPA	TRPM4	1091	Q8TD43
CPRSRALPRNPQPQP	MYRIP	411	Q8NFW9