Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin binding

MYO18B CTTN MAP1A HCLS1 KLHL4

7.89e-04479315GO:0003779
GeneOntologyBiologicalProcesspositive regulation of smooth muscle contraction

CTTN F2R KIT

2.12e-0536313GO:0045987
DomainARHGEF5_35

ARHGEF35 ARHGEF5

2.84e-062322PF15441
DomainARHGEF5/35_N

ARHGEF35 ARHGEF5

2.84e-062322IPR029212
DomainCORTACTIN

CTTN HCLS1

2.84e-062322PS51090
DomainHS1_rep

CTTN HCLS1

2.84e-062322PF02218
DomainHs1_Cortactin

CTTN HCLS1

2.84e-062322IPR003134
DomainDUF1220

NBPF4 NBPF6

1.02e-049322SM01148
DomainNBPF

NBPF4 NBPF6

1.55e-0411322PS51316
DomainDUF1220

NBPF4 NBPF6

1.55e-0411322PF06758
DomainNBPF_dom

NBPF4 NBPF6

1.55e-0411322IPR010630
DomainSH3_1

PRMT2 CTTN ARHGEF5 HCLS1

1.70e-04164324PF00018
DomainSH3_9

PRMT2 CTTN ARHGEF5

3.19e-0478323PF14604
DomainSH3

PRMT2 CTTN ARHGEF5 HCLS1

4.85e-04216324PS50002
DomainSH3

PRMT2 CTTN ARHGEF5 HCLS1

4.85e-04216324SM00326
DomainSH3_domain

PRMT2 CTTN ARHGEF5 HCLS1

5.20e-04220324IPR001452
PathwayBIOCARTA_EXTRINSIC_PATHWAY

F2R F5

1.79e-0413222M4470
PathwayBIOCARTA_EXTRINSIC_PATHWAY

F2R F5

1.79e-0413222MM1395
PathwayREACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION

F2R F5

5.27e-0422222M17879
PathwayREACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION

F2R F5

5.27e-0422222MM14558
PathwayBIOCARTA_INTRINSIC_PATHWAY

F2R F5

5.77e-0423222M15997
PathwayBIOCARTA_INTRINSIC_PATHWAY

F2R F5

5.77e-0423222MM1427
PathwayREACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS

MELTF CHGB F5

8.23e-04120223MM14982
PathwayREACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS

MELTF CHGB F5

9.05e-04124223M27285
Pubmed

Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain.

CTTN HCLS1

9.84e-07235215710041
Pubmed

A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.

NBPF4 NBPF6 NBPF5P

1.23e-062135316079250
Pubmed

The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin.

CTTN HCLS1

2.95e-06335225739456
Pubmed

Hematopoietic lineage cell-specific protein-1 (HS1) regulates PAR-mediated ERK activation and thromboxane generation in platelets.

F2R HCLS1

2.95e-06335219012179
Pubmed

A role for thrombin receptor signaling in endothelial cells during embryonic development.

F2R F5

2.95e-06335211533492
Pubmed

Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.

CTTN ARHGEF5 HCLS1

3.01e-062835318067320
Pubmed

Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.

CTTN HCLS1

5.90e-06435211689006
Pubmed

Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability.

F2R F5

9.82e-06535219687358
Pubmed

Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions.

CCL3L1 KIT

9.82e-06535215650768
Pubmed

Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation.

CCL3L1 KIT

1.47e-05635214981116
Pubmed

A critical role for mast cells and mast cell-derived IL-6 in TLR2-mediated inhibition of tumor growth.

CCL3L1 KIT

2.74e-05835221041732
Pubmed

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.

F2R KIT

2.74e-05835237995657
Pubmed

Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion.

ADAM2 KIT

6.45e-05123528786143
Pubmed

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

PHF14 CTTN MAP1A HCLS1

7.76e-0522635431452512
Pubmed

Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.

CTTN HCLS1

1.02e-04153529630982
Pubmed

A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex.

CHGB MAP1A

3.93e-04293528617512
Pubmed

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

CTTN HCLS1

4.20e-043035212522270
Pubmed

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

CTTN F2R KIT HCLS1

5.14e-0437135425241761
Pubmed

Early embryonic expression of murine coagulation system components.

F2R F5

5.41e-043435211154109
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

PEX5 CNKSR2 MAP1A ARHGEF5

8.91e-0443035435044719
Pubmed

Gender differences in genetic risk profiles for cardiovascular disease.

F2R F5

9.90e-044635218974842
Cytoband1p13.3

NBPF4 NBPF6 NBPF5P

2.05e-05693531p13.3
CytobandEnsembl 112 genes in cytogenetic band chr1p13

NBPF4 NBPF6 NBPF5P

5.62e-04211353chr1p13
Cytoband7q35

ARHGEF35 ARHGEF5

8.17e-04553527q35
CytobandEnsembl 112 genes in cytogenetic band chr7q35

ARHGEF35 ARHGEF5

1.17e-0366352chr7q35
GeneFamilyNeuroblastoma breakpoint family

NBPF4 NBPF6 NBPF5P

2.36e-0623213662
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF35 ARHGEF5

2.64e-0366212722
ToppCellBAL-Control-Myeloid-MoAM-MoAM5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCL3L1 MELTF F5 RIC3

1.37e-0518735459d28f4ee1d463ae20abb8d7e7399b504d80698a
ToppCellControl-Myeloid-MoAM5|Control / Disease group,lineage and cell class （2021.01.30）

CCL3L1 MELTF F5 RIC3

1.37e-051873548769341be67382cea2a590d962f4def7c39de883
ToppCellBAL-Control-Myeloid-MoAM-MoAM5-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCL3L1 MELTF F5 RIC3

1.37e-0518735425adf648c05c21534b4913254e73d43fc5f64e06
ToppCellBAL-Control-Myeloid-MoAM-MoAM5|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CCL3L1 MELTF F5 RIC3

1.37e-051873543b0cfa9e5ea5e7d6dda689c328b9b5110b43ee1d
ToppCellBAL-Control-Myeloid-MoAM-MoAM5-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CCL3L1 MELTF F5 RIC3

1.37e-051873540d589de12108230ced5b60229564f4a181e2f172
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_2|Classical_Monocyte / Disease condition and Cell class

CCL3L1 CTTN MAP1A F2R

1.55e-05193354add29b6abdfa49c7f0a0f49841a588d03e3bdb48
ToppCellFibroblasts-DKK3+_Fibroblasts|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

CNKSR2 MAP1A F5 NRK

1.65e-0519635424d64b67aa9b0e8215ad06f9101c1314b3483620
Diseasecalcium measurement

MELTF MYO18B MAP1A F2R HCLS1

6.23e-04628335EFO_0004838
DiseaseSmall cell carcinoma of lung

MYO18B KIT

1.67e-0354332C0149925

Protein segments in the cluster

PeptideGeneStartEntry
KHVDEYDPEDTWQDE

PRMT2

86

P55345
WKQDREDDFDWNPAD

EGFL6

411

Q8IUX8
WRTEDYSSDEQPESE

ADAM2

716

Q99965
QEDEDPSYKWREEHR

ARHGEF5

41

Q12774
QEDEDPSYKWREEHR

ARHGEF35

41

A5YM69
QDVARDYSNPKWDET

NBPF4

306

Q96M43
EEKSEPQDFQEADSW

MAP1A

1016

P78559
TDKWEDYPKSENESN

KIT

356

P10721
PARWAEEYLEQSEEK

PEX5

156

P50542
DFTQEEWRQLDPDEK

PMS2P3

16

Q13401
SYPEQEETTKEEWSQ

RIC3

326

Q7Z5B4
YDSEDDNDWRPTVVK

PHF14

206

O94880
TVESYDAQRNEWKEE

KLHL4

686

Q9C0H6
RNPNDKYEPFWEDEE

F2R

46

P25116
WEDEEKNESGLTEYR

F2R

56

P25116
PLQEKRSWEQTYEEE

EFCAB5

696

A4FU69
EDSPVLTQDRDWEAY

DNAJC9

86

Q8WXX5
TYRVDDIDWKQNPED

PIWIL3

331

Q7Z3Z3
QSEESWDEEDKRNYP

CHGB

376

P05060
WDEEDKRNYPSLELD

CHGB

381

P05060
RSVDEVNYWDKQDHP

BCKDHA

346

P12694
QKSVGWRYSDEEEDL

NRK

76

Q7Z2Y5
NSEPWAAELRSEDYE

MELTF

586

P08582
YEDDSPEWFKEDNAV

F5

1686

P12259
WDTDPDFVNDISEKE

HCLS1

21

P14317
QDVARDYSNPKWDET

NBPF5P

306

Q86XG9
QDVARDYSNPKWDET

NBPF6

306

Q5VWK0
EEWPKSEYSELDEDE

POLR2C

201

P19387
DPSEEWVQKYVSDLE

CCL3L1

76

P16619
QDYWSESDKEEADTP

CNKSR2

681

Q8WXI2
DDENSENNWRNEYPE

SLC7A6OS

241

Q96CW6
ENNWRNEYPEEESSD

SLC7A6OS

246

Q96CW6
QDYTWEDNSDEKIRI

VPS35L

806

Q7Z3J2
DWETDPDFVNDVSEK

CTTN

21

Q14247
YESESPENQTEKERW

RASGEF1C

441

Q8N431
DSDQAPEDRWYEAEK

MYO18B

501

Q8IUG5
KASERWQPDTEEEYE

SF3A3

466

Q12874
DWENPTEREDDSDKY

AGL

66

P35573