Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium/calmodulin-dependent protein kinase activity	PHKA2 CAMK1G CAMKV	2.11e-05	27	40	3	GO:0004683
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	MAP3K9 PHKA2 CAMK1G CAMKV PPM1D CSNK1G2	2.42e-04	446	40	6	GO:0004674
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	MAP3K9 PHKA2 CAMK1G CMAS CAMKV PPM1D CSNK1G2 GYS1	4.63e-04	938	40	8	GO:0016772
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	CAPN1 CAPN2	5.22e-04	17	40	2	GO:0004198
GeneOntologyMolecularFunction	protein kinase activity	MAP3K9 PHKA2 CAMK1G CAMKV PPM1D CSNK1G2	1.15e-03	600	40	6	GO:0004672
GeneOntologyMolecularFunction	exopeptidase activity	DPP7 ACE2 ERAP1	1.39e-03	110	40	3	GO:0008238
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme binding	ANKIB1 DCUN1D4	2.36e-03	36	40	2	GO:0031624
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	MAP3K9 PHKA2 CAMK1G CAMKV PPM1D CSNK1G2	2.69e-03	709	40	6	GO:0016773
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme binding	ANKIB1 DCUN1D4	3.20e-03	42	40	2	GO:0044390
GeneOntologyMolecularFunction	structural constituent of muscle	MYOM2 NEXN	3.35e-03	43	40	2	GO:0008307
GeneOntologyMolecularFunction	aminopeptidase activity	DPP7 ERAP1	3.35e-03	43	40	2	GO:0004177
GeneOntologyMolecularFunction	kinase activity	MAP3K9 PHKA2 CAMK1G CAMKV PPM1D CSNK1G2	3.89e-03	764	40	6	GO:0016301
GeneOntologyCellularComponent	calpain complex	CAPN1 CAPN2	2.14e-05	4	40	2	GO:0110158
GeneOntologyCellularComponent	caspase complex	CAPN1 CAPN2	1.59e-04	10	40	2	GO:0008303
Domain	GOLD_2	ACBD3 TMED8	4.47e-06	2	40	2	PF13897
Domain	Calpain_III	CAPN1 CAPN2	2.91e-04	12	40	2	IPR022683
Domain	calpain_III	CAPN1 CAPN2	2.91e-04	12	40	2	SM00720
Domain	C2_III	CAPN1 CAPN2	2.91e-04	12	40	2	IPR033883
Domain	Calpain_domain_III	CAPN1 CAPN2	3.44e-04	13	40	2	IPR022682
Domain	Calpain_III	CAPN1 CAPN2	3.44e-04	13	40	2	PF01067
Domain	Calpain_cysteine_protease	CAPN1 CAPN2	4.00e-04	14	40	2	IPR022684
Domain	CysPc	CAPN1 CAPN2	4.61e-04	15	40	2	SM00230
Domain	CALPAIN_CAT	CAPN1 CAPN2	4.61e-04	15	40	2	PS50203
Domain	Peptidase_C2_calpain_cat	CAPN1 CAPN2	4.61e-04	15	40	2	IPR001300
Domain	EMP24_GP25L	ACBD3 TMED8	4.61e-04	15	40	2	PF01105
Domain	Peptidase_C2	CAPN1 CAPN2	4.61e-04	15	40	2	PF00648
Domain	GOLD_dom	ACBD3 TMED8	7.47e-04	19	40	2	IPR009038
Domain	GOLD	ACBD3 TMED8	7.47e-04	19	40	2	PS50866
Domain	THIOL_PROTEASE_CYS	CAPN1 CAPN2	1.41e-03	26	40	2	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN1 CAPN2	1.52e-03	27	40	2	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN1 CAPN2	1.52e-03	27	40	2	PS00639
Domain	Pept_cys_AS	CAPN1 CAPN2	1.63e-03	28	40	2	IPR000169
Domain	EF-hand_8	CAPN1 CAPN2	2.40e-03	34	40	2	PF13833
Domain	S_TKc	MAP3K9 CAMK1G CAMKV CSNK1G2	7.11e-03	359	40	4	SM00220
Domain	Ig_I-set	MYOM2 ADAMTSL1 NEXN	7.77e-03	190	40	3	IPR013098
Domain	I-set	MYOM2 ADAMTSL1 NEXN	7.77e-03	190	40	3	PF07679
Domain	Pkinase	MAP3K9 CAMK1G CAMKV CSNK1G2	8.73e-03	381	40	4	PF00069
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	CAMK1G CAMKV	9.58e-03	69	40	2	IPR020636
Domain	IG	MYOM2 ADAMTSL1 PTPRU NEXN	1.23e-02	421	40	4	SM00409
Domain	Ig_sub	MYOM2 ADAMTSL1 PTPRU NEXN	1.23e-02	421	40	4	IPR003599
Domain	Ank	ANKIB1 ANKMY1 EHMT2	1.27e-02	228	40	3	PF00023
Pubmed	Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury.	CAPN1 CAPN2	1.29e-06	2	40	2	22140070
Pubmed	[Expression of calpain 1 and calpain 2 during the skin incised wound healing in mice].	CAPN1 CAPN2	1.29e-06	2	40	2	17619446
Pubmed	Calpain 1 and 2 are required for RNA replication of echovirus 1.	CAPN1 CAPN2	1.29e-06	2	40	2	18032503
Pubmed	Calpain-2 participates in the process of calpain-1 inactivation.	CAPN1 CAPN2	1.29e-06	2	40	2	33078830
Pubmed	Cloning of m-calpain 80 kD subunit from the axonal degeneration-resistant WLD(S) mouse mutant.	CAPN1 CAPN2	1.29e-06	2	40	2	9669314
Pubmed	Vitamin D₃ regulation of body fat, cytokines, and calpain gene expression.	CAPN1 CAPN2	1.29e-06	2	40	2	25520983
Pubmed	Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes.	CAPN1 CAPN2	1.29e-06	2	40	2	19505932
Pubmed	Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.	CAPN1 CAPN2	1.29e-06	2	40	2	15471877
Pubmed	m-Calpain is required for preimplantation embryonic development in mice.	CAPN1 CAPN2	1.29e-06	2	40	2	16433929
Pubmed	Calpains are required for invasive and metastatic potentials of human HCC cells.	CAPN1 CAPN2	1.29e-06	2	40	2	23733271
Pubmed	Involvement of calpains in growth factor-mediated migration.	CAPN1 CAPN2	1.29e-06	2	40	2	16971167
Pubmed	Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory.	CAPN1 CAPN2	1.29e-06	2	40	2	29258546
Pubmed	Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice.	CAPN1 CAPN2	1.29e-06	2	40	2	28594313
Pubmed	Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.	CAPN1 CAPN2	1.29e-06	2	40	2	22335024
Pubmed	Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.	CAPN1 CAPN2	1.29e-06	2	40	2	27622212
Pubmed	Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases.	CAPN1 CAPN2	1.29e-06	2	40	2	19781581
Pubmed	Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury.	CAPN1 CAPN2	1.29e-06	2	40	2	27185592
Pubmed	Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.	CAPN1 CAPN2	1.29e-06	2	40	2	22432027
Pubmed	Cerebral calpain in fatal falciparum malaria.	CAPN1 CAPN2	1.29e-06	2	40	2	17359359
Pubmed	Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects.	CAPN1 CAPN2	1.29e-06	2	40	2	30177812
Pubmed	Calpains: markers of tumor aggressiveness?	CAPN1 CAPN2	1.29e-06	2	40	2	20193680
Pubmed	Different expression of calpains in the anterior vaginal wall of women with and without uterovaginal prolapse.	CAPN1 CAPN2	1.29e-06	2	40	2	14980313
Pubmed	Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.	CAPN1 CAPN2	1.29e-06	2	40	2	16723743
Pubmed	Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration.	CAPN1 CAPN2	1.29e-06	2	40	2	24285894
Pubmed	Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus.	CAPN1 CAPN2	1.29e-06	2	40	2	15302874
Pubmed	Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition.	CAPN1 CAPN2	3.87e-06	3	40	2	30177525
Pubmed	The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.	CAPN1 CAPN2	3.87e-06	3	40	2	28924170
Pubmed	Expression and immunolocalization of the calpain-calpastatin system in the human oocyte.	CAPN1 CAPN2	3.87e-06	3	40	2	15950654
Pubmed	Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia.	CAPN1 CAPN2	3.87e-06	3	40	2	19318376
Pubmed	Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice.	CAPN1 CAPN2	3.87e-06	3	40	2	23977256
Pubmed	Abundance of calpain and aggrecan-cleavage products of calpain in degenerated human intervertebral discs.	CAPN1 CAPN2	3.87e-06	3	40	2	21839844
Pubmed	Extracellular Calpain/Calpastatin Balance Is Involved in the Progression of Pulmonary Hypertension.	CAPN1 CAPN2	3.87e-06	3	40	2	26974350
Pubmed	A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling.	CAPN1 CAPN2	3.87e-06	3	40	2	21415394
Pubmed	LOX-1 in macrophage migration in response to ox-LDL and the involvement of calpains.	CAPN1 CAPN2	3.87e-06	3	40	2	26393906
Pubmed	Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.	CAPN1 CAPN2	3.87e-06	3	40	2	24550490
Pubmed	A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.	CAPN1 CAPN2	3.87e-06	3	40	2	28334907
Pubmed	The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.	CAPN1 CAPN2	3.87e-06	3	40	2	18840650
Pubmed	Expression of typical calpains in mouse molar.	CAPN1 CAPN2	3.87e-06	3	40	2	19683220
Pubmed	NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain.	CAPN1 CAPN2	3.87e-06	3	40	2	8954122
Pubmed	The novel benzimidazole derivative, MPTB, induces cell apoptosis in human chondrosarcoma cells.	CAPN1 CAPN2	3.87e-06	3	40	2	21374734
Pubmed	Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains.	CAPN1 CAPN2	3.87e-06	3	40	2	16361262
Pubmed	Neurotoxicity induces cleavage of p35 to p25 by calpain.	CAPN1 CAPN2	3.87e-06	3	40	2	10830966
Pubmed	Utrophin is a calpain substrate in muscle cells.	CAPN1 CAPN2	3.87e-06	3	40	2	16598790
Pubmed	Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli.	CAPN1 CAPN2	3.87e-06	3	40	2	16632474
Pubmed	Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: mechanism of interaction and the role of divalent cations.	CAPN1 CAPN2	3.87e-06	3	40	2	3038169
Pubmed	Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.	CAPN1 CAPN2	3.87e-06	3	40	2	23536090
Pubmed	Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.	CAPN1 CAPN2	7.73e-06	4	40	2	27456359
Pubmed	Inhibition of the ERK1/2-ubiquitous calpains pathway attenuates experimental pulmonary fibrosis in vivo and in vitro.	CAPN1 CAPN2	7.73e-06	4	40	2	32017927
Pubmed	Characterization of the calcium-dependent proteolytic system in a mouse muscle cell line.	CAPN1 CAPN2	7.73e-06	4	40	2	11952156
Pubmed	Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.	CAPN1 CAPN2	7.73e-06	4	40	2	16998475
Pubmed	17-Beta-estradiol increases neuronal excitability through MAP kinase-induced calpain activation.	CAPN1 CAPN2	7.73e-06	4	40	2	19995977
Pubmed	Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens.	CAPN1 CAPN2	7.73e-06	4	40	2	12634108
Pubmed	Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events.	CAPN1 CAPN2	7.73e-06	4	40	2	9407132
Pubmed	Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord.	CAPN1 CAPN2	7.73e-06	4	40	2	8738748
Pubmed	Calpain: novel family members, activation, and physiologic function.	CAPN1 CAPN2	7.73e-06	4	40	2	8561910
Pubmed	Four genes for the calpain family locate on four distinct human chromosomes.	CAPN1 CAPN2	7.73e-06	4	40	2	2209092
Pubmed	Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration.	CAPN1 CAPN2	7.73e-06	4	40	2	35606145
Pubmed	The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway.	CAPN1 CAPN2	7.73e-06	4	40	2	27453531
Pubmed	Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.	CAPN1 CAPN2	7.73e-06	4	40	2	26966280
Pubmed	Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization.	CAPN1 CAPN2	7.73e-06	4	40	2	22555453
Pubmed	Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division.	CAPN1 CAPN2	1.29e-05	5	40	2	10825211
Pubmed	m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis.	CAPN1 CAPN2	1.29e-05	5	40	2	22064597
Pubmed	Calpain translocation during muscle fiber necrosis and regeneration in dystrophin-deficient mice.	CAPN1 CAPN2	1.29e-05	5	40	2	8806430
Pubmed	Calpain II colocalizes with detergent-insoluble rafts on human and Jurkat T-cells.	CAPN1 CAPN2	1.29e-05	5	40	2	12150984
Pubmed	Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1/2, matrix metalloproteinase-2/9, and RhoA overactivation.	CAPN1 CAPN2	1.29e-05	5	40	2	21836084
Pubmed	Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.	CAPN1 CAPN2	1.29e-05	5	40	2	17646163
Pubmed	The calpain, caspase 12, caspase 3 cascade leading to apoptosis is altered in F508del-CFTR expressing cells.	CAPN1 CAPN2	1.29e-05	5	40	2	20041182
Pubmed	Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.	CAPN1 CAPN2	1.29e-05	5	40	2	12000759
Pubmed	Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity.	CAPN1 CAPN2	1.29e-05	5	40	2	17897354
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CAPZB ANKIB1 CRNKL1 CMAS ELP3 TRIP13 NEXN CAPN1 CAPN2	1.83e-05	1353	40	9	29467282
Pubmed	Association of the calpain/calpastatin network with subcellular organelles.	CAPN1 CAPN2	1.93e-05	6	40	2	14559243
Pubmed	N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system.	CAPN1 CAPN2	2.70e-05	7	40	2	16530191
Pubmed	Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes.	CAPN1 CAPN2	2.70e-05	7	40	2	25944670
Pubmed	Structure and physiological function of calpains.	CAPN1 CAPN2	2.70e-05	7	40	2	9396712
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	CAPN1 CAPN2	2.70e-05	7	40	2	20962236
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	CAPZB DPP7 KNTC1 GLA ELP3 TRIP13 ACBD3 CAPN1 CAPN2	3.24e-05	1455	40	9	22863883
Pubmed	Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord.	CAPN1 CAPN2	3.60e-05	8	40	2	9473662
Pubmed	Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.	CAPN1 CAPN2	4.62e-05	9	40	2	10978167
Pubmed	Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.	CAPN1 CAPN2	8.45e-05	12	40	2	21791606
Pubmed	Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouse.	PHKA2 GLA	8.45e-05	12	40	2	2899541
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	CRNKL1 EHMT2 CHD5	2.30e-04	103	40	3	32744500
Pubmed	FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.	CAPN1 CAPN2	3.21e-04	23	40	2	26124079
Pubmed	Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.	PHKA2 NELFCD	3.21e-04	23	40	2	12620389
Pubmed	Defining the membrane proteome of NK cells.	CMAS ERAP1 NELFCD ACBD3 CSNK1G2 GYS1 CHD5	3.34e-04	1168	40	7	19946888
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CAPZB CRYBG1 CRNKL1 CMAS TRIM26 CHD5 CAPN1	5.19e-04	1257	40	7	36526897
Pubmed	The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.	CAPN1 CAPN2	6.26e-04	32	40	2	36278411
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	CAPZB PHKA2 GLA ELP3 TRIP13 CAPN2	6.39e-04	931	40	6	27432908
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	CAPZB DPP7 GLA CMAS TRIP13	6.61e-04	613	40	5	22268729
Pubmed	Calpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination.	CAPN1 CAPN2	6.66e-04	33	40	2	36964131
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	ANKIB1 CHD5 LRP2BP	7.32e-04	153	40	3	10718198
Pubmed	In Vitro Reconstitution and Analysis of SARS-CoV-2/Host Protein-Protein Interactions.	ACE2 GLA	9.79e-04	40	40	2	37483225
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	CAPZB GABRB2 ACE2 UMOD CAPN1 CAPN2	1.01e-03	1016	40	6	19056867
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	CAPZB TRIP13 TRIM26 CAPN2	1.03e-03	390	40	4	17643375
Interaction	TINAGL1 interactions	ACE2 CAMKV TRIP13 CAPN1	1.04e-06	39	40	4	int:TINAGL1
Interaction	GNS interactions	DPP7 GLA ACBD3 CAPN1 CAPN2	7.08e-06	136	40	5	int:GNS
GeneFamily	C2 domain containing\|Calpains	CAPN1 CAPN2	1.91e-04	15	25	2	975
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MYOM2 ADAMTSL1 NEXN	1.38e-03	161	25	3	593
GeneFamily	Ankyrin repeat domain containing	ANKIB1 ANKMY1 EHMT2	4.38e-03	242	25	3	403
GeneFamily	Fibronectin type III domain containing	MYOM2 PTPRU	2.04e-02	160	25	2	555
Coexpression	GSE21670_STAT3_KO_VS_WT_CD4_TCELL_TGFB_TREATED_DN	MAP3K9 KNTC1 ADAMTSL1 ABCA4 TRIP13	1.27e-05	199	40	5	M7443
Coexpression	GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP	ANKIB1 CAMK1G CMAS ACBD3 TRIM26	1.30e-05	200	40	5	M9299
Drug	SNJ-1945	EHMT2 CAPN1 CAPN2	1.09e-06	12	40	3	CID006857712
Drug	p-MeC	GYS1 CAPN1 CAPN2	1.80e-06	14	40	3	CID000451929
Drug	nitridochromium	CRNKL1 ABCA4	3.01e-06	2	40	2	CID000090362
Drug	creatinine	ACE2 UMOD CRNKL1 MYOM2 ABCA4 GLA	1.36e-05	302	40	6	CID000000588
Drug	Triamcinolone [124-94-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A	GABRB2 MAP3K9 PHKA2 TMEM161A ANKMY1	2.26e-05	195	40	5	2241_DN
Drug	e BW	ACE2 ABCA4 CAPN2	3.74e-05	37	40	3	CID000001338
Disease	hereditary spastic paraplegia 76 (implicated_via_orthology)	CAPN1 CAPN2	1.70e-05	5	39	2	DOID:0110821 (implicated_via_orthology)
Disease	sex interaction measurement, ulcerative colitis	EHMT2 TRIM26	2.29e-04	17	39	2	EFO_0000729, EFO_0008343
Disease	Nephritis, Tubulointerstitial	UMOD GLA	3.52e-04	21	39	2	C0041349
Disease	Nephritis, Interstitial	UMOD GLA	4.61e-04	24	39	2	C0027707
Disease	traumatic brain injury (biomarker_via_orthology)	CAPN1 CAPN2	4.61e-04	24	39	2	DOID:0081292 (biomarker_via_orthology)
Disease	Glycogen Storage Disease	PHKA2 GYS1	5.85e-04	27	39	2	C0017919
Disease	sporadic amyotrophic lateral sclerosis	MYOM2 ADAMTSL1 TMEM132E	8.43e-04	140	39	3	EFO_0001357
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN1 CAPN2	1.04e-03	36	39	2	DOID:11723 (implicated_via_orthology)
Disease	hereditary spastic paraplegia (implicated_via_orthology)	CAPN1 CAPN2	1.49e-03	43	39	2	DOID:2476 (implicated_via_orthology)
Disease	Hypertensive disease	ACE2 UMOD ERAP1	2.03e-03	190	39	3	C0020538

Protein segments in the cluster

Peptide	Gene	Start	Entry
CLEWFYEYAGTDDVV	DCUN1D4	106	Q92564
WGLDDVDYLFSEEDY	CHD5	141	Q8TDI0
DPVEDFRYIWGGFAY	ABCA4	596	P78363
DWEYLGFASPEEYAE	ANKIB1	751	Q9P2G1
YYDIDAQTFADWGVD	GLA	151	P06280
EWETVVGDDFSLYYD	EHMT2	261	Q96KQ7
TGEELGFDYGDRFWD	EHMT2	1146	Q96KQ7
SEGFEDFTGGVTEWY	CAPN1	211	P07384
YFEGGVSSVYLWDLD	CAPZB	111	P47756
WFEGEILQDGEDYQY	NEXN	616	Q0ZGT2
LAESELSGWDYEYGF	LHCGR	321	P22888
DEDYYGSAAEWGDEA	NELFCD	11	Q8IXH7
FDRSGFVFDYEYDWA	CSNK1G2	316	P78368
GLQDFDELYDWEYEG	ADAMTSL1	601	Q8N6G6
GYYIVHYEDDGWDSL	ERAP1	606	Q9NZ08
DPYEEWSYSDFFSED	KNTC1	1186	P50748
GQLYFEEGWYEEALE	LRP2BP	66	Q9P2M1
EEGSYLFWEFATDNY	ACBD3	411	Q9H3P7
LFWEFATDNYDIGFG	ACBD3	416	Q9H3P7
ATDNYDIGFGVYFEW	ACBD3	421	Q9H3P7
YGYTTDDIEFYWRGD	GABRB2	181	P47870
GDLWSYDFFSGEFVV	PPM1D	276	O15297
IKEGYYEFESPFWDD	CAMK1G	231	Q96NX5
GYGFKQEYESFFEGW	PTPRU	891	Q92729
IVFGDYTWTEFDEPF	TRIP13	51	Q15645
DDGSDAGWEEYFDYI	CRNKL1	791	Q9BZJ0
AGWEEYFDYIFPEDA	CRNKL1	796	Q9BZJ0
LAGDYEFDSPYWDDI	CAMKV	241	Q8NCB2
DYWRGDYEVNGVDGY	ACE2	201	Q9BYF1
EWGLQEGQDPFFYDY	ANKMY1	141	Q9P2S6
DYVANGGWETFLSYE	ELP3	426	Q9H9T3
YPDLSFWDTEEAYIG	CRYBG1	1186	Q9Y4K1
DEWGDNYFLVGPYTE	GYS1	56	P13807
TEGFEDFTGGIAEWY	CAPN2	201	P17655
IFFYTGNEGDVWAFA	DPP7	71	Q9UHL4
YWTAVFEYEAAGEDE	MAP3K9	56	P80192
FWTYFIIDGVFSGDA	PHKA2	331	P46019
FYVAGRDWDDFGVTE	TMEM132E	146	Q6IEE7
LEYQWFVDFAVYSGG	TMEM161A	101	Q9NX61
DWDGELYENGSFYFA	CMAS	206	Q8NFW8
DEYWRSTEYGEGYAC	UMOD	181	P07911
AGYGDGYDDWETDED	TRIM26	401	Q12899
WEFATDDYDIGFGVY	TMED8	206	Q6PL24
DDYDIGFGVYFDWTP	TMED8	211	Q6PL24
GYFVDFREEDAGEWI	MYOM2	846	P54296