Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	SLC43A2 PDPN SLC41A2 IGF1R CLCN7 CALHM1 SLC27A1 KCNJ14 SLC26A5 TTYH2 SLC28A2 SLC28A1 XKR8 KCNQ3 DISP2 XKR4 LRG1 MFSD12 GJD4 C2CD2L	1.56e-06	1289	93	20	GO:0005215
GeneOntologyMolecularFunction	cysteine-S-conjugate N-acetyltransferase activity	NAT8B NAT8	2.15e-05	2	93	2	GO:0047198
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GAL CELSR3 HTR6 GALR3 OR5H8 OR4Q3 GPR135 OR5H15 RXFP3 PTGER3 ADGRF1 OR5H1 F2RL1 OR4D2	5.73e-05	884	93	14	GO:0004930
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC43A2 PDPN SLC41A2 CLCN7 CALHM1 SLC27A1 KCNJ14 SLC26A5 TTYH2 SLC28A2 SLC28A1 KCNQ3 DISP2 LRG1 MFSD12 GJD4	1.02e-04	1180	93	16	GO:0022857
GeneOntologyMolecularFunction	nucleoside:sodium symporter activity	SLC28A2 SLC28A1	1.28e-04	4	93	2	GO:0005415
GeneOntologyMolecularFunction	nucleobase:monoatomic cation symporter activity	SLC28A2 SLC28A1	1.28e-04	4	93	2	GO:0015391
GeneOntologyMolecularFunction	pyrimidine- and adenosine-specific:sodium symporter activity	SLC28A2 SLC28A1	1.28e-04	4	93	2	GO:0015389
GeneOntologyMolecularFunction	galanin receptor activity	GAL GALR3	1.28e-04	4	93	2	GO:0004966
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	SLC43A2 SLC27A1 SLC26A5 MFSD12	1.88e-04	61	93	4	GO:1901682
GeneOntologyMolecularFunction	insulin binding	IGF1R C2CD2L	2.13e-04	5	93	2	GO:0043559
GeneOntologyMolecularFunction	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	NAT8B NAT8	3.18e-04	6	93	2	GO:0004468
GeneOntologyMolecularFunction	uridine transmembrane transporter activity	SLC28A2 SLC28A1	3.18e-04	6	93	2	GO:0015213
GeneOntologyMolecularFunction	pyrimidine nucleobase transmembrane transporter activity	SLC28A2 SLC28A1	4.44e-04	7	93	2	GO:0005350
GeneOntologyMolecularFunction	retinoic acid-responsive element binding	RXRB RXRG	4.44e-04	7	93	2	GO:0044323
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	IFNGR2 GAL IGF1R CELSR3 HTR6 GALR3 OR5H8 OR4Q3 GPR135 OR5H15 RXFP3 PTGER3 ADGRF1 OR5H1 F2RL1 OR4D2	4.80e-04	1353	93	16	GO:0004888
GeneOntologyMolecularFunction	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	EDEM2 MAN1B1	5.90e-04	8	93	2	GO:0004571
GeneOntologyMolecularFunction	pyrimidine nucleoside transmembrane transporter activity	SLC28A2 SLC28A1	5.90e-04	8	93	2	GO:0015214
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	PDPN SLC41A2 CLCN7 CALHM1 KCNJ14 SLC26A5 TTYH2 SLC28A2 SLC28A1 KCNQ3 LRG1	7.87e-04	758	93	11	GO:0015318
GeneOntologyMolecularFunction	purine nucleobase transmembrane transporter activity	SLC28A2 SLC28A1	9.42e-04	10	93	2	GO:0005345
GeneOntologyMolecularFunction	nucleoside transmembrane transporter activity	SLC28A2 SLC28A1	9.42e-04	10	93	2	GO:0005337
GeneOntologyMolecularFunction	mannosyl-oligosaccharide mannosidase activity	EDEM2 MAN1B1	9.42e-04	10	93	2	GO:0015924
GeneOntologyMolecularFunction	sulfur amino acid transmembrane transporter activity	SLC43A2 MFSD12	1.15e-03	11	93	2	GO:0000099
GeneOntologyMolecularFunction	nucleobase transmembrane transporter activity	SLC28A2 SLC28A1	1.15e-03	11	93	2	GO:0015205
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CLCN7 CALHM1 KCNJ14 KCNQ3 LRG1	1.62e-03	182	93	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CLCN7 CALHM1 KCNJ14 KCNQ3 LRG1	1.70e-03	184	93	5	GO:0022832
GeneOntologyMolecularFunction	azole transmembrane transporter activity	SLC28A2 SLC28A1	1.88e-03	14	93	2	GO:1901474
GeneOntologyMolecularFunction	peptide hormone binding	IGF1R GALR3 C2CD2L	2.15e-03	55	93	3	GO:0017046
GeneOntologyMolecularFunction	alpha-mannosidase activity	EDEM2 MAN1B1	2.17e-03	15	93	2	GO:0004559
GeneOntologyMolecularFunction	monoacylglycerol lipase activity	LIPE ABHD1	2.47e-03	16	93	2	GO:0047372
GeneOntologyMolecularFunction	mannosidase activity	EDEM2 MAN1B1	2.47e-03	16	93	2	GO:0015923
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC43A2 PDPN SLC27A1 SLC26A5 MFSD12	2.83e-03	207	93	5	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC43A2 PDPN SLC27A1 SLC26A5 MFSD12	2.89e-03	208	93	5	GO:0005342
GeneOntologyMolecularFunction	channel activity	PDPN CLCN7 CALHM1 KCNJ14 TTYH2 KCNQ3 LRG1 GJD4	3.12e-03	525	93	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	PDPN CLCN7 CALHM1 KCNJ14 TTYH2 KCNQ3 LRG1 GJD4	3.16e-03	526	93	8	GO:0022803
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	GAL GALR3 RXFP3 F2RL1	3.48e-03	133	93	4	GO:0008528
GeneOntologyMolecularFunction	endopeptidase activator activity	APH1B APH1A	3.49e-03	19	93	2	GO:0061133
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC41A2 CLCN7 CALHM1 KCNJ14 SLC26A5 TTYH2 SLC28A2 SLC28A1 KCNQ3 LRG1	3.81e-03	793	93	10	GO:0015075
GeneOntologyMolecularFunction	peptide receptor activity	GAL GALR3 RXFP3 F2RL1	4.17e-03	140	93	4	GO:0001653
GeneOntologyMolecularFunction	gated channel activity	CLCN7 CALHM1 KCNJ14 TTYH2 KCNQ3 LRG1	4.72e-03	334	93	6	GO:0022836
GeneOntologyMolecularFunction	phospholipid transporter activity	XKR8 XKR4 C2CD2L	4.99e-03	74	93	3	GO:0005548
GeneOntologyMolecularFunction	phospholipid scramblase activity	XKR8 XKR4	5.09e-03	23	93	2	GO:0017128
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CALHM1 KCNJ14 KCNQ3 LRG1	5.58e-03	152	93	4	GO:0022843
GeneOntologyMolecularFunction	nuclear steroid receptor activity	RXRB RXRG	6.00e-03	25	93	2	GO:0003707
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC41A2 CALHM1 KCNJ14 SLC28A2 SLC28A1 KCNQ3 LRG1	6.02e-03	465	93	7	GO:0046873
GeneOntologyBiologicalProcess	peptidyl-lysine N6-acetylation	NAT8B NAT8	1.97e-05	2	92	2	GO:0018003
GeneOntologyBiologicalProcess	membrane protein intracellular domain proteolysis	APH1B SPPL2A APH1A	3.02e-05	14	92	3	GO:0031293
GeneOntologyBiologicalProcess	regulation of myofibroblast contraction	PDPN PTGER3	5.89e-05	3	92	2	GO:1904328
GeneOntologyBiologicalProcess	organic anion transport	SLC43A2 PDPN HTR6 G6PC3 CALHM1 SLC27A1 SLC26A5 TTYH2 PTGER3 MFSD12	9.96e-05	515	92	10	GO:0015711
GeneOntologyBiologicalProcess	serotonergic neuron axon guidance	VANGL2 CELSR3	1.95e-04	5	92	2	GO:0036515
GeneOntologyBiologicalProcess	mannoprotein catabolic process	EDEM2 MAN1B1	1.95e-04	5	92	2	GO:0006058
GeneOntologyBiologicalProcess	mannoprotein metabolic process	EDEM2 MAN1B1	1.95e-04	5	92	2	GO:0006056
GeneOntologyBiologicalProcess	myofibroblast contraction	PDPN PTGER3	1.95e-04	5	92	2	GO:1990764
GeneOntologyBiologicalProcess	sulfur compound transport	SLC43A2 SLC27A1 SLC26A5 MFSD12	2.04e-04	65	92	4	GO:0072348
GeneOntologyCellularComponent	endoplasmic reticulum membrane	IFNGR2 APH1B NAT8B LMF2 SPPL2A G6PC3 HLA-B APH1A CALHM1 HPN SLC27A1 TMEM86B NAT8 UBAC2 DEGS2 HSD11B2 MAN1B1 C2CD2L	1.35e-05	1293	93	18	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	IFNGR2 APH1B NAT8B LMF2 SPPL2A G6PC3 HLA-B APH1A CALHM1 HPN SLC27A1 TMEM86B NAT8 UBAC2 DEGS2 HSD11B2 MAN1B1 C2CD2L	1.43e-05	1299	93	18	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	IFNGR2 APH1B NAT8B LMF2 SPPL2A G6PC3 HLA-B APH1A CALHM1 HPN SLC27A1 TMEM86B NAT8 UBAC2 DEGS2 HSD11B2 MAN1B1 C2CD2L	1.91e-05	1327	93	18	GO:0042175
GeneOntologyCellularComponent	late recombination nodule	NAT8B NAT8	5.86e-05	3	93	2	GO:0005715
GeneOntologyCellularComponent	recombination nodule	NAT8B NAT8	1.17e-04	4	93	2	GO:0005713
GeneOntologyCellularComponent	gamma-secretase complex	APH1B APH1A	4.05e-04	7	93	2	GO:0070765
Domain	Aph-1	APH1B APH1A	2.25e-05	2	89	2	IPR009294
Domain	Aph-1	APH1B APH1A	2.25e-05	2	89	2	PF06105
Domain	CNT_N_dom	SLC28A2 SLC28A1	6.72e-05	3	89	2	IPR002668
Domain	C_nuclsd_transpt	SLC28A2 SLC28A1	6.72e-05	3	89	2	IPR008276
Domain	CNT_C_dom	SLC28A2 SLC28A1	6.72e-05	3	89	2	IPR011657
Domain	C_nuclsd_transpt_met_bac	SLC28A2 SLC28A1	6.72e-05	3	89	2	IPR018270
Domain	Gate_dom	SLC28A2 SLC28A1	6.72e-05	3	89	2	IPR011642
Domain	Nucleos_tra2_N	SLC28A2 SLC28A1	6.72e-05	3	89	2	PF01773
Domain	Nucleos_tra2_C	SLC28A2 SLC28A1	6.72e-05	3	89	2	PF07662
Domain	Gate	SLC28A2 SLC28A1	6.72e-05	3	89	2	PF07670
Domain	Glyco_hydro_47	EDEM2 MAN1B1	4.64e-04	7	89	2	PF01532
Domain	-	EDEM2 MAN1B1	4.64e-04	7	89	2	1.50.10.50
Domain	Glyco_hydro_47	EDEM2 MAN1B1	6.17e-04	8	89	2	IPR001382
Domain	Retinoid-X_rcpt/HNF4	RXRB RXRG	9.86e-04	10	89	2	IPR000003
Domain	XK_rel	XKR8 XKR4	1.20e-03	11	89	2	IPR018629
Domain	XK-related	XKR8 XKR4	1.20e-03	11	89	2	PF09815
Domain	GPCR_Rhodpsn_7TM	HTR6 GALR3 OR4Q3 GPR135 OR5H15 RXFP3 PTGER3 OR5H1 F2RL1 OR4D2	1.31e-03	670	89	10	IPR017452
Domain	7tm_1	HTR6 GALR3 OR4Q3 GPR135 OR5H15 RXFP3 PTGER3 OR5H1 F2RL1 OR4D2	1.41e-03	677	89	10	PF00001
Domain	G_PROTEIN_RECEP_F1_1	HTR6 GALR3 OR4Q3 GPR135 OR5H15 RXFP3 PTGER3 OR5H1 F2RL1 OR4D2	1.54e-03	685	89	10	PS00237
Domain	G_PROTEIN_RECEP_F1_2	HTR6 GALR3 OR4Q3 GPR135 OR5H15 RXFP3 PTGER3 OR5H1 F2RL1 OR4D2	1.65e-03	691	89	10	PS50262
Domain	GPCR_Rhodpsn	HTR6 GALR3 OR4Q3 GPR135 OR5H15 RXFP3 PTGER3 OR5H1 F2RL1 OR4D2	1.66e-03	692	89	10	IPR000276
Domain	Furin_repeat	FRAS1 IGF1R	3.27e-03	18	89	2	IPR006212
Domain	FU	FRAS1 IGF1R	3.27e-03	18	89	2	SM00261
Domain	VWC_out	FRAS1 MUC5B	3.64e-03	19	89	2	SM00215
Domain	PA	RNF130 SPPL2A	3.64e-03	19	89	2	PF02225
Domain	PA_domain	RNF130 SPPL2A	3.64e-03	19	89	2	IPR003137
Domain	Acetyltransf_1	NAT8B NAT8	5.32e-03	23	89	2	PF00583
Domain	GNAT	NAT8B NAT8	6.27e-03	25	89	2	PS51186
Domain	GNAT_dom	NAT8B NAT8	6.27e-03	25	89	2	IPR000182
Domain	VWC	FRAS1 MUC5B	7.83e-03	28	89	2	PF00093
Domain	EGF_LAM_2	CELSR3 NTN3	8.96e-03	30	89	2	PS50027
Domain	EGF_LAM_1	CELSR3 NTN3	8.96e-03	30	89	2	PS01248
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	SLC43A2 PDPN TPST2 SPPL2A APH1A RUSC1 UBAC2 SFT2D3 MAN1B1 GJD4	2.70e-07	430	94	10	16303743
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	COL4A5 GAL TPST2 ENDOD1 TMEM161A FRAS1 IGF1R LMF2 CELSR3 HLA-B EDEM2 UBAC2 TTC17 OGFOD3 MAN1B1	7.85e-07	1201	94	15	35696571
Pubmed	Physical mapping of the retinoid X receptor B gene in mouse and human.	HLA-B RXRB RXRG	3.11e-06	11	94	3	7806300
Pubmed	The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides.	NAT8B NAT8	7.23e-06	2	94	2	25301944
Pubmed	Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide.	GAL GALR3	7.23e-06	2	94	2	27940914
Pubmed	Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation.	VANGL2 CELSR3	7.23e-06	2	94	2	28057866
Pubmed	Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif.	APH1B APH1A	7.23e-06	2	94	2	16757808
Pubmed	Identification of distinct gamma-secretase complexes with different APH-1 variants.	APH1B APH1A	7.23e-06	2	94	2	15286082
Pubmed	Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development.	RXRB RXRG	7.23e-06	2	94	2	9150186
Pubmed	Immunofluorescent analysis of the spinal cord in dysraphic mice.	VANGL2 NCAM1	7.23e-06	2	94	2	8722511
Pubmed	Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo.	APH1B APH1A	7.23e-06	2	94	2	15665098
Pubmed	Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.	SLC28A2 SLC28A1	7.23e-06	2	94	2	10455109
Pubmed	The role of N-acetyltransferase 8 in mesenchymal stem cell-based therapy for liver ischemia/reperfusion injury in rats.	NAT8B NAT8	7.23e-06	2	94	2	25057902
Pubmed	Prostaglandin I2 upregulates the expression of anterior pharynx-defective-1α and anterior pharynx-defective-1β in amyloid precursor protein/presenilin 1 transgenic mice.	APH1B APH1A	7.23e-06	2	94	2	27240539
Pubmed	Retinoid x receptor gamma control of affective behaviors involves dopaminergic signaling in mice.	RXRB RXRG	7.23e-06	2	94	2	20620876
Pubmed	Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism.	NAT8B NAT8	7.23e-06	2	94	2	33846551
Pubmed	Evidence that the modulatory effect of galanin on inflammatory edema formation is mediated by the galanin receptor 3 in the murine microvasculature.	GAL GALR3	7.23e-06	2	94	2	18679831
Pubmed	Alterations in cranial morphogenesis in the Lp mutant mouse.	VANGL2 NCAM1	7.23e-06	2	94	2	8719347
Pubmed	Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells.	SLC28A2 SLC28A1	7.23e-06	2	94	2	17187757
Pubmed	Association of the HLA-B27 antigen and the CTLA4 gene CT60/rs3087243 polymorphism with ankylosing spondylitis in Algerian population: A case-control study.	HLA-B CTLA4	7.23e-06	2	94	2	29675891
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	COL4A5 TPST2 FRAS1 IGF1R KMT2B CELSR3 CLCN7 C15orf39 DISP2 TEP1 MFSD12 PRRT4 C2CD2L	8.72e-06	1105	94	13	35748872
Pubmed	Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.	APH1B APH1A	2.16e-05	3	94	2	12857757
Pubmed	Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia.	SLC28A2 SLC28A1	2.16e-05	3	94	2	12411296
Pubmed	Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.	APH1B APH1A	2.16e-05	3	94	2	20382452
Pubmed	Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3.	SLC28A2 SLC28A1	2.16e-05	3	94	2	17453413
Pubmed	aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.	APH1B APH1A	2.16e-05	3	94	2	12110170
Pubmed	Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.	RXRB RXRG	2.16e-05	3	94	2	11053444
Pubmed	Analysis of CD28 and CTLA-4 gene polymorphisms in Turkish patients with Behcet's disease.	HLA-B CTLA4	2.16e-05	3	94	2	17284227
Pubmed	Impaired locomotion and dopamine signaling in retinoid receptor mutant mice.	RXRB RXRG	2.16e-05	3	94	2	9452386
Pubmed	Retinoid X receptors: X-ploring their (patho)physiological functions.	RXRB RXRG	2.16e-05	3	94	2	15608692
Pubmed	gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.	APH1B APH1A	2.16e-05	3	94	2	19299585
Pubmed	Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.	NAT8B NAT8	2.16e-05	3	94	2	24556617
Pubmed	Retinoid receptors trigger neuritogenesis in retinal degenerations.	RXRB RXRG	2.16e-05	3	94	2	21940995
Pubmed	Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling.	APH1B APH1A	2.16e-05	3	94	2	24891237
Pubmed	Characterization of deoxyribonucleoside transport mediated by concentrative nucleoside transporters.	SLC28A2 SLC28A1	2.16e-05	3	94	2	33910126
Pubmed	An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression.	RXRB RXRG	2.16e-05	3	94	2	9883728
Pubmed	RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.	RXRB RXRG	2.16e-05	3	94	2	8799145
Pubmed	Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels.	NAT8B NAT8	2.16e-05	3	94	2	19011241
Pubmed	Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.	RXRB RXRG	2.16e-05	3	94	2	7831303
Pubmed	Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine.	SLC28A2 SLC28A1	2.16e-05	3	94	2	10087507
Pubmed	Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.	RXRB RXRG	2.16e-05	3	94	2	1312497
Pubmed	Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies.	RXRB RXRG	2.16e-05	3	94	2	7980510
Pubmed	Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.	RXRB RXRG	2.16e-05	3	94	2	12514092
Pubmed	Chromosomal localization of the human retinoid X receptors.	RXRB RXRG	2.16e-05	3	94	2	8034312
Pubmed	Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney.	APH1B APH1A	2.16e-05	3	94	2	12952904
Pubmed	Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance.	SLC28A2 SLC28A1	2.16e-05	3	94	2	28385889
Pubmed	The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.	RXRB RXRG	2.16e-05	3	94	2	11839661
Pubmed	Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.	APH1B APH1A	2.16e-05	3	94	2	28588032
Pubmed	Multiplexing of receptor occupancy measurements for pharmacodynamic biomarker assessment of biopharmaceuticals.	IGF1R CTLA4	2.16e-05	3	94	2	26332491
Pubmed	Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis.	NAT8B NAT8	2.16e-05	3	94	2	11397015
Pubmed	Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice.	RXRB RXRG	4.32e-05	4	94	2	10079186
Pubmed	The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons.	GAL GALR3	4.32e-05	4	94	2	12533601
Pubmed	Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors.	RXRB RXRG	4.32e-05	4	94	2	33692389
Pubmed	Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.	SLC28A2 SLC28A1	4.32e-05	4	94	2	18635603
Pubmed	By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice.	APH1B APH1A	4.32e-05	4	94	2	26293690
Pubmed	Alcoholism is associated with GALR3 but not two other galanin receptor genes.	GAL GALR3	4.32e-05	4	94	2	17083333
Pubmed	Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation.	NAT8B NAT8	4.32e-05	4	94	2	22267734
Pubmed	Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis.	IGF1R TEP1	4.32e-05	4	94	2	18938767
Pubmed	Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.	RXRB RXRG	4.32e-05	4	94	2	1310259
Pubmed	Differential role of planar cell polarity gene Vangl2 in embryonic and adult mammalian kidneys.	VANGL2 NCAM1	4.32e-05	4	94	2	32203543
Pubmed	Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes.	APH1B APH1A	4.32e-05	4	94	2	15629423
Pubmed	Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.	RXRB RXRG	4.32e-05	4	94	2	26355550
Pubmed	Role of the transporter regulator protein (RS1) in the modulation of concentrative nucleoside transporters (CNTs) in epithelia.	SLC28A2 SLC28A1	4.32e-05	4	94	2	22492015
Pubmed	Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.	RXRB RXRG	4.32e-05	4	94	2	19686701
Pubmed	Brain galanin system genes interact with life stresses in depression-related phenotypes.	GAL GALR3	4.32e-05	4	94	2	24706871
Pubmed	Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.	RXRB RXRG	4.32e-05	4	94	2	9804293
Pubmed	Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse.	APH1B APH1A	4.32e-05	4	94	2	26299962
Pubmed	APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.	APH1B APH1A	7.19e-05	5	94	2	12471034
Pubmed	Developmental expression of murine retinoid X receptor (RXR) genes.	RXRB RXRG	7.19e-05	5	94	2	8199055
Pubmed	Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients.	SLC28A2 SLC28A1	7.19e-05	5	94	2	17926640
Pubmed	Retinoic acid signaling is necessary for the development of the organ of Corti.	RXRB RXRG	7.19e-05	5	94	2	10452855
Pubmed	Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.	APH1B APH1A	7.19e-05	5	94	2	12740439
Pubmed	Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.	GAL GALR3	7.19e-05	5	94	2	24517231
Pubmed	APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development.	APH1B APH1A	7.19e-05	5	94	2	15634781
Pubmed	Planar cell polarity signaling components are a direct target of β-amyloid-associated degeneration of glutamatergic synapses.	VANGL2 CELSR3	7.19e-05	5	94	2	34407949
Pubmed	Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.	APH1B APH1A	7.19e-05	5	94	2	22140537
Pubmed	Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes.	RXRB RXRG	1.08e-04	6	94	2	11328745
Pubmed	Galanin promotes neuronal differentiation from neural progenitor cells in vitro and contributes to the generation of new olfactory neurons in the adult mouse brain.	GAL GALR3	1.08e-04	6	94	2	24726665
Pubmed	Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear.	RXRB RXRG	1.08e-04	6	94	2	9548551
Pubmed	Functional specificity of the two retinoic acid receptor RAR and RXR families in myogenesis.	RXRB RXRG	1.08e-04	6	94	2	9464546
Pubmed	RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells.	RXRB RXRG	1.08e-04	6	94	2	8801169
Pubmed	A decade of molecular biology of retinoic acid receptors.	RXRB RXRG	1.08e-04	6	94	2	8801176
Pubmed	Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma.	RXRB RXRG	1.08e-04	6	94	2	22205725
Pubmed	Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.	APH1B APH1A	1.08e-04	6	94	2	12297508
Pubmed	TGIF inhibits retinoid signaling.	RXRB RXRG	1.08e-04	6	94	2	16428452
Pubmed	APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.	APH1B APH1A	1.08e-04	6	94	2	12763021
Pubmed	A genetic dissection of the retinoid signalling pathway in the mouse.	RXRB RXRG	1.08e-04	6	94	2	10604193
Pubmed	The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains.	RXRB RXRG	1.08e-04	6	94	2	9153406
Pubmed	Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.	APH1B APH1A	1.08e-04	6	94	2	15474363
Pubmed	Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.	RXRB RXRG	1.08e-04	6	94	2	20557428
Pubmed	The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.	RXRB RXRG	1.08e-04	6	94	2	9806918
Pubmed	Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.	RXRB RXRG	1.08e-04	6	94	2	7947324
Pubmed	Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.	APH1B APH1A	1.08e-04	6	94	2	27608597
Pubmed	Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis.	RXRB RXRG	1.08e-04	6	94	2	9075714
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	SLC43A2 TMEM161A HTR6 G6PC3 APH1A TTYH2 RXFP3 F2RL1 MFSD12	1.16e-04	697	94	9	28298427
Pubmed	Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8.	TMEM161A G6PC3 MAN1B1	1.28e-04	36	94	3	38070861
Pubmed	Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.	RXRB RXRG	1.50e-04	7	94	2	9428411
Pubmed	HLA-DRB1*11: a strong risk factor for acquired severe ADAMTS13 deficiency-related idiopathic thrombotic thrombocytopenic purpura in Caucasians.	HLA-B CTLA4	1.50e-04	7	94	2	20141578
Pubmed	Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases.	RXRB RXRG	1.50e-04	7	94	2	15635645
Pubmed	Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression.	RXRB RXRG	1.50e-04	7	94	2	8090775
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5H8 OR5H15 OR5H1	1.91e-04	54	94	3	chr3q11
Cytoband	1q22-q23	VANGL2 RXRG	3.19e-04	13	94	2	1q22-q23
Cytoband	3q12.1	OR5H8 OR5H15	8.49e-04	21	94	2	3q12.1
Cytoband	19p13.3	PEAK3 LRG1 MADCAM1 MFSD12	1.47e-03	237	94	4	19p13.3
GeneFamily	Proline rich transmembrane proteins	PRRT3 PRRT4	6.47e-05	4	60	2	688
GeneFamily	Blood group antigens\|XK related family	XKR8 XKR4	5.84e-04	11	60	2	955
GeneFamily	Solute carriers	SLC43A2 SLC41A2 SLC27A1 SLC26A5 SLC28A2 SLC28A1	1.94e-03	395	60	6	752
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	COL4A5 ENDOD1 TMEM161A ZDHHC24 IGF1R LMF2 SPPL2A KMT2B CLCN7 G6PC3 HLA-B NCAM1 UBAC2 OGFOD3 ABHD1 C2CD2L	2.53e-09	681	94	16	M5314
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	COL4A5 ENDOD1 TMEM161A ZDHHC24 IGF1R LMF2 SPPL2A KMT2B CLCN7 G6PC3 HLA-B NCAM1 UBAC2 OGFOD3 ABHD1 C2CD2L	3.98e-09	703	94	16	MM1055
Coexpression	GSE37532_TREG_VS_TCONV_CD4_TCELL_FROM_VISCERAL_ADIPOSE_TISSUE_UP	COL4A5 CALHM1 PRRT3 MFSD6L ADGRF1 MADCAM1	9.78e-06	136	94	6	M8939
Coexpression	FUJIWARA_PARK2_HEPATOCYTE_PROLIFERATION_UP	NAT8B NAT8 ABHD1	2.42e-05	16	94	3	MM559
Coexpression	IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR	RNF130 TMEM161A SPPL2A G6PC3 HPN C15orf39 XKR8 OGFOD3 PTGER3	4.02e-05	458	94	9	M1606
Coexpression	HE_LIM_SUN_FETAL_LUNG_C7_MID_SCHWANN_CELL	PDPN COL4A5 ENDOD1 HLA-B TTYH2 XKR4 RXRG	5.18e-05	268	94	7	M45796
Coexpression	IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR	RNF130 TMEM161A SPPL2A G6PC3 HPN C15orf39 XKR8 OGFOD3 PTGER3	6.05e-05	483	94	9	MM1012
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EDEM2 MUC5B OGFOD3 CTLA4 F2RL1 MAN1B1	1.89e-06	174	94	6	3f4277763e312b46ebd4401ea4a2f5d4c850c768
ToppCell	droplet-Lung-nan-21m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EDEM2 MUC5B OGFOD3 CTLA4 F2RL1 MAN1B1	1.89e-06	174	94	6	fad66d1a8407574b6a835e0bdb824a53afa58650
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IFNGR2 PDPN APH1B TMEM86B F2RL1 C2CD2L	1.95e-06	175	94	6	711ace94fa9a763c6ae48171a690953f25deebe4
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC43A2 MFSD6L HSD11B2 XKR4 PTGER3 DNASE1L2	2.08e-06	177	94	6	6d89042bda8e244babb68929e84b25edcb545a77
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC43A2 MFSD6L HSD11B2 XKR4 PTGER3 DNASE1L2	2.08e-06	177	94	6	daaccf1249dcf816df4caca695a944f53078291a
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC43A2 MFSD6L HSD11B2 XKR4 PTGER3 DNASE1L2	2.08e-06	177	94	6	338bdda26796bf4e16072878c070212d1006cf57
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC43A2 MFSD6L HSD11B2 XKR4 PTGER3 DNASE1L2	2.08e-06	177	94	6	c5a16f984c836dbf7d0faf061677844167ab612a
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PCDHB5 NCAM1 MFSD6L HSD11B2 XKR4 PTGER3	3.97e-06	198	94	6	62059185afdf66126a6fbc899ce611c47e7a0feb
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAL NCAM1 DISP2 MFSD6L LRG1	1.89e-05	154	94	5	71ffc23a2e02e27cabbdbeaa622e59e9f4a4cd9d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDPN TTYH2 NCAM1 XKR4 RXRG	1.89e-05	154	94	5	30cb4bb297fa815adb829f3b5cafca56fcbcb810
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDPN TTYH2 NCAM1 XKR4 RXRG	1.89e-05	154	94	5	ade094e2947761a0a34daa8fcff3e9ea8437e4a5
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAL NCAM1 DISP2 MFSD6L LRG1	1.89e-05	154	94	5	46155f36d3983f637b55d7525b675c8828f6ab2e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDPN TTYH2 NCAM1 XKR4 RXRG	1.89e-05	154	94	5	42bd8f88fd075a2d4edde394785decad88a2660a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDPN TTYH2 NCAM1 XKR4 RXRG	1.89e-05	154	94	5	6425d9861148586466febd6eceae1b1f9b9a14c1
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC43A2 SLC26A5 HSD11B2 PTGER3 ADGRF1	2.27e-05	160	94	5	86fde32f096eaf9ea3677f57169cdcc0a57bb8dd
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Club_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 MFSD6L MUC5B DEGS2 ADGRF1	2.95e-05	169	94	5	8c96e1baa38ec5e777e627ab9dbce025e771f2c0
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8B SLC28A1 NAT8 RXFP3 DEGS2	2.95e-05	169	94	5	ee27bcfe3f9a295ec5fb0a375d77d1050e5cbaad
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8B SLC28A1 NAT8 RXFP3 DEGS2	2.95e-05	169	94	5	922086f218135b734b7d370b871923e50141edce
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 MFSD6L MUC5B DEGS2 ADGRF1	2.95e-05	169	94	5	86041be5d3aeab5b9269f7912791b944f325a1b4
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF130 ENDOD1 XKR4 TMEM95 RXRG	3.39e-05	174	94	5	667035a11b68745fa8446d6c68214713be42710f
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NAT8B SLC28A2 HSD11B2 LRG1	3.48e-05	87	94	4	cc89f4176b70d4eb5b5bf0ff2319b5f1f9e292c0
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NAT8B SLC28A2 HSD11B2 LRG1	3.48e-05	87	94	4	4274e04fa4aca85c2cefd8c5e03d0fa4a4f15536
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NAT8B SLC28A2 HSD11B2 LRG1	3.48e-05	87	94	4	54cbdf80aae3595eaace20c7cbac763282558213
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NAT8B SLC28A2 HSD11B2 LRG1	3.48e-05	87	94	4	8b1a0bd5d6af32afaca19e9c69f86530bbaa309d
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNJ14 DISP2 F2RL1 LRG1 PRRT4	4.10e-05	181	94	5	cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EDEM2 C15orf39 CTLA4 F2RL1 MAN1B1	4.54e-05	185	94	5	238938a4682b44e88a30b86b13af4feeabe9553d
ToppCell	wk_15-18-Epithelial-PNS-MFNG+_DBH+_neuron\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	GAL CELSR3 KCNJ14 NCAM1 PTGER3	4.66e-05	186	94	5	72f7427d62d65e37bb0bf99229a1b75df081a128
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDPN COL4A5 FRAS1 NCAM1 F2RL1	4.78e-05	187	94	5	806075c2531a7f5c1da38b85ea494a3b4b5e92ec
ToppCell	COVID-19-kidney-CD-PC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL4A5 FRAS1 HSD11B2 PTGER3 ADGRF1	4.91e-05	188	94	5	8f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell	COVID-19-Epithelial-Ionocytes\|COVID-19 / Condition, Lineage and Cell class	VANGL2 NCAM1 MFSD6L PTGER3 ADGRF1	4.91e-05	188	94	5	a581cb9528d0febbf3addbb4f6bc140f91a584e6
ToppCell	critical-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC43A2 NCAM1 MFSD6L HSD11B2 PTGER3	5.16e-05	190	94	5	05a2c3549b68f49081723bf35db14974274419d5
ToppCell	PSB-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NCAM1 MFSD6L HSD11B2 XKR4 PTGER3	5.29e-05	191	94	5	8f4637e801554e2343b974fe7794f01dd2151418
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC43A2 FRAS1 HPN SLC28A1 PTGER3	5.56e-05	193	94	5	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 IGF1R TMEM232 HPN PTGER3	5.56e-05	193	94	5	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 FRAS1 TMEM232 HPN PTGER3	5.98e-05	196	94	5	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SLC41A2 COL4A5 LIPE HPN LRG1	6.12e-05	197	94	5	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	Tracheal-10x5prime-Stromal-Schwann-Schwann_nonmyelinating\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TTYH2 NCAM1 ABHD1 XKR4 RXRG	6.12e-05	197	94	5	e239caae24f40564a24ad909754f5436f767ccdb
ToppCell	Healthy_donor-Non-classical_Monocyte\|Healthy_donor / disease group, cell group and cell class (v2)	IFNGR2 APH1B RNF130 C15orf39 MFSD12	6.27e-05	198	94	5	d4eae333fa100db3ea2d4cbe7a1d6ab14816f0e2
ToppCell	Healthy/Control-Non-classical_Monocyte\|Healthy/Control / Disease group and Cell class	IFNGR2 APH1B RNF130 C15orf39 MFSD12	6.27e-05	198	94	5	0badaf1fa5328d06291c3624d0f63196ffc81527
ToppCell	Kidney-Tubules\|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.	IGF1R HPN HSD11B2 PTGER3 ADGRF1	6.58e-05	200	94	5	0726456906e078244a9cff35aee8c5bce4566fb1
Disease	basal cell carcinoma	HLA-B EDEM2 UBAC2 CTLA4 RXFP3	2.34e-04	189	86	5	EFO_0004193
Disease	N-acetyl-2-aminooctanoate measurement	NAT8B NAT8	5.44e-04	12	86	2	EFO_0800567
Disease	Myasthenia gravis	HLA-B CTLA4	6.41e-04	13	86	2	EFO_0004991
Disease	obesity (biomarker_via_orthology)	LIPE IGF1R SLC27A1 HSD11B2	9.15e-04	147	86	4	DOID:9970 (biomarker_via_orthology)
Disease	sarcoidosis (is_implicated_in)	HLA-B CTLA4	9.81e-04	16	86	2	DOID:11335 (is_implicated_in)
Disease	type 1 diabetes mellitus (is_marker_for)	GAL NCAM1 HSD11B2	1.23e-03	72	86	3	DOID:9744 (is_marker_for)
Disease	myocardial infarction (biomarker_via_orthology)	IGF1R SLC27A1 NCAM1 HSD11B2	1.25e-03	160	86	4	DOID:5844 (biomarker_via_orthology)
Disease	Mood Disorders	GAL HTR6 NCAM1 PFKL	1.50e-03	168	86	4	C0525045
Disease	hepatocellular carcinoma (is_implicated_in)	IGF1R KMT2B CTLA4 TEP1	1.97e-03	181	86	4	DOID:684 (is_implicated_in)
Disease	Behcet Syndrome	HLA-B UBAC2	2.22e-03	24	86	2	C0004943
Disease	Involutional paraphrenia	GAL GALR3	2.41e-03	25	86	2	C1571983
Disease	Psychosis, Involutional	GAL GALR3	2.41e-03	25	86	2	C1571984
Disease	Involutional Depression	GAL GALR3	2.41e-03	25	86	2	C0011574
Disease	Left ventricular mass to end-diastolic volume ratio	IGF1R HLA-B	2.41e-03	25	86	2	EFO_0010556
Disease	AIDS	HLA-B RXRG	2.61e-03	26	86	2	EFO_0000765

Protein segments in the cluster

Peptide	Gene	Start	Entry
SVAFKLLILLLGSWA	VANGL2	151	Q9ULK5
IAGAFFWLVSLLISS	APH1B	36	Q8WW43
LVLGAWSLAALASFL	HTR6	146	P50406
RTLFLLLLLAASAWG	LRG1	21	P02750
AGAQLSLELLFSDWG	NKAPP1	46	Q8N9T2
ALSLLIADVWFIVGA	ADGRF1	631	Q5T601
ALGWSFVLLTTLLAF	CALHM1	186	Q8IU99
AALAVLAAAGWIALS	HSD11B2	56	P80365
ALALAFATLLLGTWN	DISP2	971	A7MBM2
LTFLWNGEDSALLEL	MUC5B	181	Q9HC84
FLAILLLLWEAGSEA	PCDHB5	16	Q9Y5E4
ALLWDAASGSLLQDL	RFWD3	726	Q6PCD5
WFIIASFGLLSALTL	RNF130	386	Q86XS8
LLLGNLAFVDAWISS	OR5H15	61	A6NDH6
LFLGSLAFVDAWLSS	OR5H8	61	P0DN80
SNSGLLDVVWFFLLL	OR4D2	201	P58180
AGFVLTALLLWSSLG	OGFOD3	51	Q6PK18
WSLAGLELVALADAS	KIAA0100	966	Q14667
VWLGLALALAEFAVL	FRAS1	6	Q86XX4
ALWTSSAVLGLLLLA	MADCAM1	321	Q13477
LENLLFSAVLLGWGS	SLC43A2	21	Q8N370
AALLILLWALTTEGD	NCR3LG1	11	Q68D85
VAGAFFWLVSLLLAS	APH1A	36	Q96BI3
VSGDWLLLLETFAIF	KCNQ3	151	O43525
TLFTLGLDLSWSISL	G6PC3	216	Q9BUM1
LWAVSALSFLLGLAD	GJD4	201	Q96KN9
GLSFSLLLWATLNAA	CLCN7	171	P51798
WGSFSLTLIDALDTL	EDEM2	71	Q9BV94
WLALGSLFALAGLLE	ENDOD1	6	O94919
TSLWGLLFLSAALSL	IGF1R	11	P08069
FILSLGSVAFWELLT	MFSD6L	246	Q8IWD5
GLSSSWELQLFLFLL	OR4Q3	16	Q8NH05
ALVSALASGADWLFI	PFKL	216	P17858
AVLLGVWLAVLAFAL	PTGER3	176	P43115
LQLSAALKFLEAWGA	PEAK3	286	Q6ZS72
LLLKLLESAFGWFDA	KMT2B	1496	Q9UMN6
LLLSAALALTETWAG	HLA-B	11	P01889
TWILVLSLSLAGALF	HIDE1	116	A8MVS5
LLLLTAIGAASWAIV	HPN	26	P05981
FSEWFGLGLTLIDAL	MAN1B1	281	Q9UKM7
LAFWLIASLHGDLAA	KCNJ14	106	Q9UNX9
LLLGNLAFVDAWISS	OR5H1	61	A6NKK0
WLSLLAALAHLAAAE	KICS2	51	Q96MD2
WGLLLTAGTLFAALS	NTN3	6	O00634
AAWLLGAAILLAASL	F2RL1	6	P55085
AAVGLVWLLAALFSA	GALR3	141	O60755
ALQLLAGAWLTALGF	GPR135	226	Q8IZ08
ALLAALWALEAAGTA	DNASE1L2	6	Q92874
GWAALLILFAASLLT	C2CD2L	11	O14523
SLLLAAALSASAGLW	GAL	11	P22466
VSLAAGLFLLALSLW	COL4A5	6	P29400
LVQLAADLAIFALWG	DEGS2	191	Q6QHC5
AILGSLFLIASISWL	MARCHF4	241	Q9P2E8
LWSLLLLLGVFAAAA	IFNGR2	6	P38484
DFLLWILAAVSSGLF	CTLA4	161	P16410
LLLVSASWLFGLLAV	CELSR3	2731	Q9NYQ7
SGLLVILAFAAWVAL	MFSD12	346	Q6NUT3
LSWFLFLDALLVISG	MEP1B	6	Q16820
ELTWALALALAAVAA	PRRT3	686	Q5FWE3
RLGASSWLNSFLELS	LIPE	821	Q05469
LWFSSLQEDAGLLSL	RUSC1	611	Q9BVN2
IWALAALASLPSAIF	RXFP3	221	Q9NSD7
LSDSAFDSGRLWLLV	TMEM161A	306	Q9NX61
WDSLLLETGFLAVLV	LMF2	126	Q9BU23
IWLTTFVSSLFLGLD	SLC26A5	471	P58743
ALLFVLGSASLWVLA	PDPN	6	Q86YL7
RKFALLWSLGSALAL	SFT2D3	106	Q587I9
LWSLGSALALAGSAL	SFT2D3	111	Q587I9
LASAGFDRLILLWNV	SNRNP40	81	Q96DI7
SFGDLITLAILAWIS	SLC41A2	321	Q96JW4
LAVLAFINAALSWLG	SLC28A2	431	O43868
LLRAGWNELLIASFS	RXRB	371	P28702
GTWADTFSLLLALAV	ABHD1	11	Q96SE0
FRSLLETAWLNGLAL	C15orf39	1006	Q6ZRI6
DLIWTLFFLGTAVSL	NCAM1	6	P13591
LWEAKILLLSIFGAF	TMEM95	141	Q3KNT9
LILDFLGIAWSDAVL	TPST2	251	O60704
ALEAFSGTLLLSAAW	TMEM235	186	A6NFC5
TLFLTAFDGLLELWD	TEP1	1731	Q99973
AGAASVVSLALLWLL	SLC27A1	6	Q6PCB7
WLDSVLALLVLGEAA	TMEM232	301	C9JQI7
LSLLLSWASLAADGS	TTYH2	251	Q9BSA4
GAALLWGFLLQLTAA	SPPL2A	11	Q8TCT8
AFATAGWLVSLVLLV	TMEM104	36	Q8NE00
GFTAAASLVSLAWAL	XKR4	336	Q5GH76
AAFLSGLLLALSCWG	PRRT4	506	C9JH25
LLRAGWNELLIASFS	RXRG	301	P48443
ALLFTLSDGVLAWDT	TMEM86B	176	Q8N661
FFSLLATAILGAVSW	TMEM168	361	Q9H0V1
WLLSLSALLSVAARG	TTC17	21	Q96AE7
LAVLDFINAALSWLG	SLC28A1	436	O00337
LTALWAAAVGLELAY	ZDHHC24	21	Q6UX98
LSAFSSWEELASLGL	SF3A3	246	Q12874
LLGSWVLSALFDFLL	UBAC2	96	Q8NBM4
ALLGLASVALQLFSW	XKR8	51	Q9H6D3
VSGSWILALVFSLSL	NAT8B	56	Q9UHF3
VSGSWLLALVFSISL	NAT8	56	Q9UHE5