Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	PIN_4	SWT1 SMG5 DIS3	6.88e-07	4	105	3	PF13638
Domain	Guanine_nucleotide-bd_bsu	GNB1 GNB2 GNB3	1.71e-06	5	105	3	IPR016346
Domain	PIN_dom	SWT1 SMG5 DIS3	3.41e-06	6	105	3	IPR002716
Domain	PINc	SWT1 SMG5 DIS3	3.41e-06	6	105	3	SM00670
Domain	WD40_repeat_dom	KNTC1 LRRK2 LRRK1 WDR76 DMXL1 TAF5 GNB1 GNB2 GNB3 DCAF7	6.77e-06	297	105	10	IPR017986
Domain	Gprotein_B	GNB1 GNB2 GNB3	2.01e-05	10	105	3	IPR001632
Domain	COR	LRRK2 LRRK1	3.13e-05	2	105	2	IPR032171
Domain	COR	LRRK2 LRRK1	3.13e-05	2	105	2	PF16095
Domain	EGF_3	MASP1 LRP1B TMEFF2 FBN1 MALRD1 UMODL1 FBN3 SORL1	5.45e-05	235	105	8	PS50026
Domain	EGF-like_dom	MASP1 LRP1B TMEFF2 FBN1 MALRD1 UMODL1 FBN3 SORL1	8.17e-05	249	105	8	IPR000742
Domain	Requiem/DPF_N_dom	DPF2 DPF3	9.36e-05	3	105	2	IPR025750
Domain	Requiem_N	DPF2 DPF3	9.36e-05	3	105	2	PF14051
Domain	FBN	FBN1 FBN3	9.36e-05	3	105	2	IPR011398
Domain	EGF-like_CS	MASP1 LRP1B TMEFF2 FBN1 MALRD1 UMODL1 FBN3 SORL1	1.13e-04	261	105	8	IPR013032
Domain	EGF_CA	MASP1 LRP1B FBN1 UMODL1 FBN3	1.24e-04	86	105	5	PF07645
Domain	EGF_2	MASP1 LRP1B TMEFF2 FBN1 MALRD1 UMODL1 FBN3 SORL1	1.26e-04	265	105	8	PS01186
Domain	WD40	LRRK2 WDR76 DMXL1 TAF5 GNB1 GNB2 GNB3 DCAF7	1.36e-04	268	105	8	SM00320
Domain	WD40_repeat	LRRK2 WDR76 DMXL1 TAF5 GNB1 GNB2 GNB3 DCAF7	1.50e-04	272	105	8	IPR001680
Domain	ROC_dom	LRRK2 LRRK1	1.86e-04	4	105	2	IPR020859
Domain	ROC	LRRK2 LRRK1	1.86e-04	4	105	2	PS51424
Domain	EGF_Ca-bd_CS	MASP1 LRP1B FBN1 UMODL1 FBN3	2.18e-04	97	105	5	IPR018097
Domain	EGF_CA	MASP1 LRP1B FBN1 UMODL1 FBN3	2.40e-04	99	105	5	PS01187
Domain	ASX_HYDROXYL	MASP1 LRP1B FBN1 UMODL1 FBN3	2.52e-04	100	105	5	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	MASP1 LRP1B FBN1 UMODL1 FBN3	3.30e-04	106	105	5	IPR000152
Domain	EGF	LRP1B TMEFF2 FBN1 MALRD1 UMODL1 FBN3 SORL1	3.65e-04	235	105	7	SM00181
Domain	cEGF	LRP1B FBN1 FBN3	4.09e-04	26	105	3	PF12662
Domain	cEGF	LRP1B FBN1 FBN3	4.09e-04	26	105	3	IPR026823
Domain	-	LRRK2 WDR76 DMXL1 TAF5 GNB1 GNB2 GNB3 DCAF7	5.84e-04	333	105	8	2.130.10.10
Domain	EGF_1	MASP1 LRP1B TMEFF2 FBN1 MALRD1 UMODL1 FBN3	5.95e-04	255	105	7	PS00022
Domain	WD40/YVTN_repeat-like_dom	LRRK2 WDR76 DMXL1 TAF5 GNB1 GNB2 GNB3 DCAF7	6.08e-04	335	105	8	IPR015943
Domain	EGF_CA	MASP1 LRP1B FBN1 UMODL1 FBN3	6.28e-04	122	105	5	SM00179
Domain	TB	FBN1 FBN3	6.45e-04	7	105	2	PF00683
Domain	WD40	WDR76 DMXL1 TAF5 GNB1 GNB2 GNB3 DCAF7	6.52e-04	259	105	7	PF00400
Domain	EGF-like_Ca-bd_dom	MASP1 LRP1B FBN1 UMODL1 FBN3	6.76e-04	124	105	5	IPR001881
Domain	-	FBN1 FBN3	8.57e-04	8	105	2	3.90.290.10
Domain	WD_REPEATS_1	WDR76 DMXL1 TAF5 GNB1 GNB2 GNB3 DCAF7	9.87e-04	278	105	7	PS00678
Domain	WD_REPEATS_2	WDR76 DMXL1 TAF5 GNB1 GNB2 GNB3 DCAF7	1.01e-03	279	105	7	PS50082
Domain	WD_REPEATS_REGION	WDR76 DMXL1 TAF5 GNB1 GNB2 GNB3 DCAF7	1.01e-03	279	105	7	PS50294
Domain	TB_dom	FBN1 FBN3	1.10e-03	9	105	2	IPR017878
Domain	TB	FBN1 FBN3	1.10e-03	9	105	2	PS51364
Domain	G-protein_beta_WD-40_rep	TAF5 GNB1 GNB2 GNB3	1.35e-03	85	105	4	IPR020472
Domain	LDLR_class-A_CS	LRP1B MALRD1 SORL1	1.47e-03	40	105	3	IPR023415
Domain	Growth_fac_rcpt_	LRP1B IGF1R FBN1 UMODL1 FBN3	1.88e-03	156	105	5	IPR009030
Domain	-	SWT1 DIS3	1.99e-03	12	105	2	3.40.50.1010
Domain	Ldl_recept_a	LRP1B MALRD1 SORL1	2.06e-03	45	105	3	PF00057
Domain	-	LRP1B MALRD1 SORL1	2.20e-03	46	105	3	4.10.400.10
Domain	WD40_repeat_CS	TAF5 GNB1 GNB2 GNB3 DCAF7	2.34e-03	164	105	5	IPR019775
Domain	MIRO-like	LRRK2 LRRK1	2.35e-03	13	105	2	IPR013684
Domain	Roc	LRRK2 LRRK1	2.35e-03	13	105	2	PF08477
Domain	LDLRA_1	LRP1B MALRD1 SORL1	2.49e-03	48	105	3	PS01209
Domain	LDrepeatLR_classA_rpt	LRP1B MALRD1 SORL1	2.64e-03	49	105	3	IPR002172
Domain	LDLa	LRP1B MALRD1 SORL1	2.64e-03	49	105	3	SM00192
Domain	LDLRA_2	LRP1B MALRD1 SORL1	2.64e-03	49	105	3	PS50068
Domain	PIN_domain-like	SWT1 DIS3	2.73e-03	14	105	2	IPR029060
Domain	Ldl_recept_b	LRP1B SORL1	2.73e-03	14	105	2	PF00058
Domain	LDLRB	LRP1B SORL1	2.73e-03	14	105	2	PS51120
Domain	ARM-type_fold	CAND2 LRRK2 INTS1 CLTC LTN1 ZER1 USP35	3.04e-03	339	105	7	IPR016024
Domain	LY	LRP1B SORL1	3.13e-03	15	105	2	SM00135
Domain	LDLR_classB_rpt	LRP1B SORL1	3.13e-03	15	105	2	IPR000033
Domain	G_crystallin-rel	ADAMTS2 CRYGD	4.52e-03	18	105	2	IPR011024
Domain	EGF	LRP1B TMEFF2 MALRD1 FBN3	5.59e-03	126	105	4	PF00008
Pathway	WP_RAS_SIGNALING	PLA2G4E RASGRP1 IGF1R GNB1 GNB2 GNB3 PLCE1	4.15e-05	184	72	7	M39764
Pathway	REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR	GNB1 GNB2 GNB3	1.17e-04	19	72	3	MM15021
Pathway	REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR	GNB1 GNB2 GNB3	1.17e-04	19	72	3	M926
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_CDC42	GNB1 GNB2 GNB3	1.37e-04	20	72	3	MM15572
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_CDC42	GNB1 GNB2 GNB3	1.37e-04	20	72	3	M27853
Pathway	REACTOME_PRESYNAPTIC_FUNCTION_OF_KAINATE_RECEPTORS	GNB1 GNB2 GNB3	1.59e-04	21	72	3	M27409
Pathway	REACTOME_PRESYNAPTIC_FUNCTION_OF_KAINATE_RECEPTORS	GNB1 GNB2 GNB3	1.59e-04	21	72	3	MM15159
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12	GNB1 GNB2 GNB3	1.83e-04	22	72	3	MM15016
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12	GNB1 GNB2 GNB3	1.83e-04	22	72	3	M841
Pathway	REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION	GNB1 GNB2 GNB3	2.10e-04	23	72	3	MM15033
Pathway	KEGG_MEDICUS_REFERENCE_LPAR_GNB_G_RHO_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	2.10e-04	23	72	3	M47549
Pathway	REACTOME_G_PROTEIN_ACTIVATION	GNB1 GNB2 GNB3	2.39e-04	24	72	3	M13115
Pathway	REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR	GNB1 GNB2 GNB3	2.39e-04	24	72	3	MM15088
Pathway	REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR	GNB1 GNB2 GNB3	2.39e-04	24	72	3	M18308
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_PI3K_AKT_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	2.39e-04	24	72	3	M47460
Pathway	REACTOME_G_PROTEIN_ACTIVATION	GNB1 GNB2 GNB3	2.39e-04	24	72	3	MM14794
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1	GNB1 GNB2 GNB3	2.71e-04	25	72	3	MM15056
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1	GNB1 GNB2 GNB3	2.71e-04	25	72	3	M811
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA	GNB1 GNB2 GNB3	2.71e-04	25	72	3	M14301
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA	GNB1 GNB2 GNB3	3.05e-04	26	72	3	MM15017
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	3.05e-04	26	72	3	M47561
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	3.05e-04	26	72	3	M47562
Pathway	KEGG_MEDICUS_REFERENCE_CCR5_GNB_G_PLCB_G_PKC_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	3.05e-04	26	72	3	M47557
Pathway	KEGG_MEDICUS_REFERENCE_CXCR_GNB_G_PI3K_AKT_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	3.05e-04	26	72	3	M47456
Pathway	KEGG_MEDICUS_REFERENCE_CXCR_GNB_G_ERK_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	3.42e-04	27	72	3	M47454
Pathway	REACTOME_GPER1_SIGNALING	GNB1 GNB2 GNB3	3.42e-04	27	72	3	MM15664
Pathway	REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION	GNB1 GNB2 GNB3	3.82e-04	28	72	3	M10679
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_PI3K_JNK_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	4.24e-04	29	72	3	M47466
Pathway	REACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING	IGF1R GNB1 GNB2 GNB3	4.69e-04	71	72	4	MM15590
Pathway	REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING	GNB1 GNB2 GNB3	4.70e-04	30	72	3	M18193
Pathway	REACTOME_ACTIVATION_OF_G_PROTEIN_GATED_POTASSIUM_CHANNELS	GNB1 GNB2 GNB3	4.70e-04	30	72	3	MM14542
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	GNB1 GNB2 GNB3	5.18e-04	31	72	3	MM15094
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	5.18e-04	31	72	3	M47554
Pathway	KEGG_MEDICUS_REFERENCE_CCR_CXCR_GNB_G_PI3K_RAC_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	5.18e-04	31	72	3	M47455
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_ERK_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	5.18e-04	31	72	3	M47459
Pathway	KEGG_MEDICUS_REFERENCE_CCR2_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	5.18e-04	31	72	3	M47540
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	5.18e-04	31	72	3	M47541
Pathway	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS	GNB1 GNB2 GNB3	5.70e-04	32	72	3	M861
Pathway	REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING	GNB1 GNB2 GNB3	5.70e-04	32	72	3	M14309
Pathway	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS	GNB1 GNB2 GNB3	5.70e-04	32	72	3	MM15148
Pathway	REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING	GNB1 GNB2 GNB3	5.70e-04	32	72	3	MM15143
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PI3K_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	5.70e-04	32	72	3	M47962
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	GNB1 GNB2 GNB3	5.70e-04	32	72	3	MM14983
Pathway	REACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING	IGF1R GNB1 GNB2 GNB3	5.78e-04	75	72	4	M27874
Pathway	REACTOME_PLATELET_HOMEOSTASIS	GNB1 GNB2 GNB3 ATP2A1	6.08e-04	76	72	4	MM15051
Pathway	REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING	GNB1 GNB2 GNB3	6.24e-04	33	72	3	MM15027
Pathway	REACTOME_SIGNAL_AMPLIFICATION	GNB1 GNB2 GNB3	6.24e-04	33	72	3	MM15020
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	GNB1 GNB2 GNB3	6.24e-04	33	72	3	MM15058
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNB_G_RHO_SIGNALING_PATHWAY	GNB1 GNB2 GNB3	6.24e-04	33	72	3	M47550
Pathway	REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS	GNB1 GNB2 GNB3	6.24e-04	33	72	3	MM15066
Pathway	REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS	GNB1 GNB2 GNB3	6.24e-04	33	72	3	M10322
Pathway	REACTOME_SIGNAL_AMPLIFICATION	GNB1 GNB2 GNB3	6.24e-04	33	72	3	M9379
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	GNB1 GNB2 GNB3	6.24e-04	33	72	3	M11575
Pathway	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	GNB1 GNB2 GNB3	7.44e-04	35	72	3	M1075
Pathway	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	GNB1 GNB2 GNB3	8.08e-04	36	72	3	MM14544
Pathway	REACTOME_COOPERATION_OF_PDCL_PHLP1_AND_TRIC_CCT_IN_G_PROTEIN_BETA_FOLDING	GNB1 GNB2 GNB3	9.48e-04	38	72	3	M27656
Pathway	REACTOME_PLATELET_HOMEOSTASIS	GNB1 GNB2 GNB3 ATP2A1	9.69e-04	86	72	4	M916
Pathway	REACTOME_CHAPERONIN_MEDIATED_PROTEIN_FOLDING	GNB1 GNB2 GNB3	1.02e-03	39	72	3	MM15003
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	GNB1 GNB2 GNB3	1.10e-03	40	72	3	MM15115
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	GNB1 GNB2 GNB3	1.27e-03	42	72	3	M791
Pathway	REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION	GNB1 GNB2 GNB3	1.36e-03	43	72	3	M29837
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	GNB1 GNB2 GNB3	1.36e-03	43	72	3	M933
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	GNB1 GNB2 GNB3	1.36e-03	43	72	3	M954
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	GNB1 GNB2 GNB3	1.46e-03	44	72	3	MM15709
Pathway	REACTOME_CA2_PATHWAY	GNB1 GNB2 GNB3	1.55e-03	45	72	3	MM15040
Pathway	REACTOME_GPER1_SIGNALING	GNB1 GNB2 GNB3	1.55e-03	45	72	3	M45008
Pathway	REACTOME_PROTEIN_FOLDING	GNB1 GNB2 GNB3 DCAF7	1.57e-03	98	72	4	M776
Pathway	REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION	GNB1 GNB3	1.64e-03	12	72	2	MM15036
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	GNB1 GNB2 GNB3	1.87e-03	48	72	3	M10775
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	GNB1 GNB2 GNB3	2.36e-03	52	72	3	M920
Pathway	KEGG_ONE_CARBON_POOL_BY_FOLATE	SHMT2 FTCD	3.33e-03	17	72	2	M12039
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	GNB1 GNB2 GNB3	3.55e-03	60	72	3	MM15708
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	GNB1 GNB2 GNB3	3.55e-03	60	72	3	MM14964
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	GNB1 GNB2 GNB3	3.55e-03	60	72	3	M976
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	CLTC GNB1 GNB2 GNB3	3.59e-03	123	72	4	MM14988
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	GNB1 GNB2 GNB3	3.72e-03	61	72	3	MM15071
Pathway	REACTOME_CA2_PATHWAY	GNB1 GNB2 GNB3	3.89e-03	62	72	3	M27321
Pubmed	Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes.	GNB1 GNB2 GNB3	2.75e-08	3	106	3	11913780
Pubmed	Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.	GNB1 GNB2 GNB3	1.10e-07	4	106	3	1543505
Pubmed	The role of G protein beta subunits in the release of ATP from human erythrocytes.	GNB1 GNB2 GNB3	1.10e-07	4	106	3	12512701
Pubmed	The cationic region of Rhes mediates its interactions with specific Gbeta subunits.	GNB1 GNB2 GNB3	1.10e-07	4	106	3	19255495
Pubmed	Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits.	GNB1 GNB2 GNB3	5.47e-07	6	106	3	16884933
Pubmed	A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.	GNB1 GNB2 GNB3	1.52e-06	8	106	3	9789084
Pubmed	Gβγ interacts with mTOR and promotes its activation.	GNB1 GNB2 GNB3	1.52e-06	8	106	3	24462769
Pubmed	The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8.	GNB1 GNB2 GNB3	1.52e-06	8	106	3	2328987
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MYT1L SPTBN2 PEG3 ADGRB3 SESN3 SMG5 FTCD LRP1B CBR3 CCDC85A STAT6 KANSL2 FBN1 CLTC GNB1 ARHGAP21	1.78e-06	1285	106	16	35914814
Pubmed	Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.	GNB1 GNB2 GNB3	2.28e-06	9	106	3	10339615
Pubmed	Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.	GNB1 GNB2 GNB3	3.25e-06	10	106	3	28334111
Pubmed	Expression of olfactory receptors, G-proteins and AxCAMs during the development and maturation of olfactory sensory neurons in the mouse.	GNB1 GNB2 GNB3	3.25e-06	10	106	3	9733924
Pubmed	The G protein subunit gene families.	GNB1 GNB2 GNB3	4.46e-06	11	106	3	10644457
Pubmed	A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation.	GNB1 GNB2 GNB3	4.46e-06	11	106	3	25982117
Pubmed	Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice.	GNB1 GNB2 GNB3	5.93e-06	12	106	3	20186915
Pubmed	Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers.	GNB1 GNB2 GNB3	5.93e-06	12	106	3	16301321
Pubmed	Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families.	GNB1 GNB2 GNB3	5.93e-06	12	106	3	8636150
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	MYT1L ADGRB3 SMG5 DIS3 FBXL7 TLN1 CACNA1G	6.12e-06	225	106	7	12168954
Pubmed	Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.	LRRK2 LRRK1	9.20e-06	2	106	2	18272292
Pubmed	Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.	GNB1 GNB2	9.20e-06	2	106	2	20525682
Pubmed	Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice.	LRRK2 LRRK1	9.20e-06	2	106	2	35534227
Pubmed	Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.	LRRK2 LRRK1	9.20e-06	2	106	2	17394548
Pubmed	Insulin-like growth factor-1 receptor expression masks the antiinflammatory and glucose uptake capacity of insulin in vascular smooth muscle cells.	LEPR IGF1R	9.20e-06	2	106	2	19122171
Pubmed	Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions?	LRRK2 LRRK1	9.20e-06	2	106	2	22988872
Pubmed	Genetic Analysis of LRRK1 and LRRK2 Variants in Essential Tremor Patients.	LRRK2 LRRK1	9.20e-06	2	106	2	29812962
Pubmed	Dynamic and redundant regulation of LRRK2 and LRRK1 expression.	LRRK2 LRRK1	9.20e-06	2	106	2	18045479
Pubmed	Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease.	LRRK2 LRRK1	9.20e-06	2	106	2	20144646
Pubmed	Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease.	LRRK2 LRRK1	9.20e-06	2	106	2	17225181
Pubmed	Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway.	LRRK2 LRRK1	9.20e-06	2	106	2	17324517
Pubmed	Cerd4, third member of the d4 gene family: expression and organization of genomic locus.	DPF2 DPF3	9.20e-06	2	106	2	11845289
Pubmed	Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.	FBN1 FBN3	9.20e-06	2	106	2	15221638
Pubmed	Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man.	GNB1 GNB3	9.20e-06	2	106	2	1979057
Pubmed	Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.	LRRK2 LRRK1	9.20e-06	2	106	2	33459343
Pubmed	Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.	LRRK2 LRRK1	9.20e-06	2	106	2	29056298
Pubmed	IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice.	LEPR IGF1R	9.20e-06	2	106	2	29430464
Pubmed	Expression of leucine-rich-repeat-kinase 2 (LRRK2) during embryonic development.	LRRK2 LRRK1	9.20e-06	2	106	2	20403420
Pubmed	Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C.	GNB1 GNB2 GNB3	9.77e-06	14	106	3	19168127
Pubmed	Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.	GNB1 GNB2 GNB3	1.22e-05	15	106	3	12486123
Pubmed	Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.	GNB1 GNB2 GNB3	1.81e-05	17	106	3	19376773
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	CTTNBP2 CAND2 PEG3 ZNF407 TLN1 CLTC ATP2A1 ARHGAP21 PLCE1	2.23e-05	497	106	9	23414517
Pubmed	Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.	DPF2 DPF3	2.76e-05	3	106	2	18765789
Pubmed	The d4 gene family in the human genome.	DPF2 DPF3	2.76e-05	3	106	2	8812431
Pubmed	Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.	GNB1 GNB2	2.76e-05	3	106	2	25485910
Pubmed	Defective STAT signaling by the leptin receptor in diabetic mice.	LEPR STAT6	2.76e-05	3	106	2	8692797
Pubmed	Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue.	LEPR MUC5AC	2.76e-05	3	106	2	20422702
Pubmed	LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.	LRRK2 CLTC	2.76e-05	3	106	2	29735704
Pubmed	Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.	LRRK2 LRRK1	2.76e-05	3	106	2	22952686
Pubmed	Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment.	LRRK2 LRRK1	2.76e-05	3	106	2	19712061
Pubmed	Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.	STAT6 PLCE1	2.76e-05	3	106	2	27322543
Pubmed	G protein beta gamma subunits. Simplified purification and properties of novel isoforms.	GNB1 GNB2	2.76e-05	3	106	2	8308009
Pubmed	Elevation of LncRNA ENST00000453774.1 Prevents Renal Fibrosis by Upregulating FBN1, IGF1R, and KLF7.	IGF1R FBN1	2.76e-05	3	106	2	34614499
Pubmed	Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.	LRRK2 LEPR	2.76e-05	3	106	2	22357653
Pubmed	ETAA1 acts at stalled replication forks to maintain genome integrity.	HELB FANCD2 ATRIP	3.52e-05	21	106	3	27723720
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CAND2 ADGRB3 SMG5 LRRK1 KBTBD2 DIS3 FBXL7 CACNA1G ARHGAP20	3.62e-05	529	106	9	14621295
Pubmed	Protein phosphatase 1α interacting proteins in the human brain.	PPP1R3D CLTC KCTD20 SORL1	5.39e-05	67	106	4	22321011
Pubmed	Mdm2-mediated ubiquitination of PKCβII in the nucleus mediates clathrin-mediated endocytic activity.	CLTC GNB1	5.50e-05	4	106	2	31634457
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN3	5.50e-05	4	106	2	25034023
Pubmed	Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.	BACH2 STAT6	5.50e-05	4	106	2	27581382
Pubmed	A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice.	STAT6 FBN1	5.50e-05	4	106	2	10486156
Pubmed	Interleukin-13 induces mucin 5AC production involving STAT6/SPDEF in human airway epithelial cells.	STAT6 MUC5AC	5.50e-05	4	106	2	21275604
Pubmed	Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.	LRRK2 LRRK1	5.50e-05	4	106	2	23526378
Pubmed	Fine mapping of the autosomal recessive polycystic kidney disease locus (PKHD1) and the genes MUT, RDS, CSNK2 beta, and GSTA1 at 6p21.1-p12.	PKHD1 MMUT	5.50e-05	4	106	2	9503014
Pubmed	Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.	GNB1 GNB3	5.50e-05	4	106	2	25093805
Pubmed	Asprosin is a centrally acting orexigenic hormone.	LEPR FBN1	5.50e-05	4	106	2	29106398
Pubmed	G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus.	GNB1 GNB2	5.50e-05	4	106	2	15955845
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	AHCTF1 SPTBN2 PEG3 SHMT2 WDR76 DNTTIP1 CDK13 TLN1 CLTC GNB1 MUC5AC HSPA14 ZNF574 DCAF7	7.33e-05	1371	106	14	36244648
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	CTTNBP2 ADAMTS2 ZSWIM5 BACH2 LRRK2 SHMT2 WDR76 DMXL1 IGF1R LTN1 USP35 HSPA14 FBN3	8.50e-05	1215	106	13	15146197
Pubmed	G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development.	GNB1 GNB2 GNB3	8.53e-05	28	106	3	8858601
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SPTBN2 INTS1 AMER3 FBXL7 TLN1 CLTC PKHD1 LRRC7 ARHGAP20 FBN3	8.70e-05	736	106	10	29676528
Pubmed	Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma.	GNB1 GNB3	9.15e-05	5	106	2	8550614
Pubmed	Localization of the gene for a third G protein beta-subunit to mouse chromosome 6 near Raf-1.	GNB1 GNB3	9.15e-05	5	106	2	1572642
Pubmed	Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.	BACH2 RASGRP1	9.15e-05	5	106	2	18840781
Pubmed	Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.	ITGA9 LEPR	9.15e-05	5	106	2	37224018
Pubmed	Molecular basis for recognition of Gly/N-degrons by CRL2ZYG11B and CRL2ZER1.	GIMAP5 ZER1	9.15e-05	5	106	2	34214466
Pubmed	Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.	RASGRP1 PLCE1	9.15e-05	5	106	2	18172297
Pubmed	Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.	GNB1 GNB2	9.15e-05	5	106	2	7649993
Pubmed	A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson's Research.	LRRK2 LRRK1	9.15e-05	5	106	2	24046356
Pubmed	Reduced oxidative capacity in macrophages results in systemic insulin resistance.	LEPR STAT6	9.15e-05	5	106	2	29674655
Pubmed	Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.	ZSWIM5 SPTBN2 LRRK2 CBR3 CDK13	9.66e-05	149	106	5	22664934
Pubmed	Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse.	DPF2 SCML2 DPF3	1.05e-04	30	106	3	31043422
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	INTS1 LRRC7 USP35 ARHGAP20 ARHGAP21	1.09e-04	153	106	5	10718198
Pubmed	Glucagon and regulation of glucose metabolism.	GNB1 GNB2 GNB3	1.16e-04	31	106	3	12626323
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MYT1L CAND2 AHCTF1 PEG3 SHMT2 ITGA9 DIS3 STAT6 SCML2 CLTC LTN1 ARHGAP21	1.18e-04	1084	106	12	11544199
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	CTTNBP2 SPTBN2 ADGRB3 LRRC7 GNB1 GNB2	1.24e-04	251	106	6	27507650
Pubmed	The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.	SPTBN2 GNB1 GNB3	1.28e-04	32	106	3	23704327
Pubmed	Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.	GNB1 GNB2	1.37e-04	6	106	2	16371464
Pubmed	ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway.	FANCD2 ATRIP	1.37e-04	6	106	2	22258451
Pubmed	Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.	LRRK2 LRRK1	1.37e-04	6	106	2	23675505
Pubmed	Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization.	IGF1R CLTC	1.37e-04	6	106	2	18286479
Pubmed	Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.	GNB1 GNB2	1.37e-04	6	106	2	7665596
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	GNB1 GNB2	1.37e-04	6	106	2	9238069
Pubmed	Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.	GNB1 GNB3	1.91e-04	7	106	2	10570481
Pubmed	Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.	MYT1L SWT1 FBXL7	2.15e-04	38	106	3	28218735
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	LRRK1 WDR76 LRRC7	2.50e-04	40	106	3	25011449
Pubmed	Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study.	LEPR IGF1R	2.55e-04	8	106	2	18249219
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZSWIM5 PEG3 TLN1 CLTC LRRC7 ARHGAP21 PLCE1	2.57e-04	407	106	7	12693553
Pubmed	LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.	LRRK2 LRRK1	3.27e-04	9	106	2	22899650
Pubmed	Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.	KBTBD2 LEPR	3.27e-04	9	106	2	27708159
Pubmed	Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo.	TLN1 CLTC	3.27e-04	9	106	2	22976293
Pubmed	Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit.	GNB1 GNB2	3.27e-04	9	106	2	16498633
GeneFamily	WD repeat domain containing	WDR76 DMXL1 TAF5 GNB1 GNB2 GNB3 DCAF7	8.93e-05	262	73	7	362
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	DPF2 ZNF441 DMXL1 FANCD2 RASGRP1 LYG1 PLCE1	2.62e-07	179	107	7	5be883d7d0be3180bb9844e4a757f0dd247294e4
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPTBN2 PEG3 CYTL1 C17orf113 CRYGD FBN1	1.00e-06	137	107	6	6d90da42dcc06aa895f920218055068f3c76d57d
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	KNTC1 FAM200A VMO1 CLCN4 LTN1 MUC5AC	3.39e-06	169	107	6	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KNTC1 ADAMTS2 PEG3 FANCD2 FBN1 CACNA1G	3.39e-06	169	107	6	335619507857383c3b0b507cdf05d786ed59e585
ToppCell	mild_COVID-19-HSPC\|World / disease group, cell group and cell class (v2)	MCMDC2 CYTL1 ITGA9 CRYGD CLIP3 FBN1	3.51e-06	170	107	6	85c476e0bc496445e868a88849960598d97bdea2
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RAB9B MASP1 CTTNBP2 CLIP3 SCML2 FBN1	5.03e-06	181	107	6	b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCell	COVID-19_Moderate-HSPC\|World / disease group, cell group and cell class	SPTBN2 CYTL1 ITGA9 CRYGD CLIP3 FBN1	5.53e-06	184	107	6	ccc93babe1fcdeb66b78e1d8414357877a7c45bd
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	MASP1 CTTNBP2 ADAMTS2 LEPR FBN1 FBXL7	5.71e-06	185	107	6	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYT1L RAB9B SPTBN2 PEG3 AMER3 LRRC7	5.89e-06	186	107	6	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	Healthy-HSPC\|World / disease group, cell group and cell class	SPTBN2 CYTL1 ITGA9 CRYGD FBN1 ATP2A1	6.07e-06	187	107	6	8cd9e5499e5c2b2321ecbcf780df37fe0f165ac9
ToppCell	facs-Skin-nan-18m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 ITGA9 LEPR FBN1 CACNA1G ARHGAP20	6.45e-06	189	107	6	29287525120be2953b76881ba3cfc4379c265e7a
ToppCell	facs-Skin-nan-18m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 ITGA9 LEPR FBN1 CACNA1G ARHGAP20	6.45e-06	189	107	6	7150dad9a92a715487c2d8130fa01b752ea69663
ToppCell	facs-Skin-nan-18m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 ITGA9 LEPR FBN1 CACNA1G ARHGAP20	6.45e-06	189	107	6	6e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 ITGA9 LEPR CCDC85A FBN1 FBXL7	7.27e-06	193	107	6	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	CTTNBP2 ADAMTS2 BACH2 ADGRB3 FBN1 ARHGAP20	7.27e-06	193	107	6	acad568621ed677031797b8c2e34dafea798d681
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CTTNBP2 ADAMTS2 BACH2 ADGRB3 FBN1 ARHGAP20	7.49e-06	194	107	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	(1)_T_cells-(1)_T_CD4_naive\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	GIMAP5 BACH2 SESN3 HELB IGF1R SORL1	7.71e-06	195	107	6	d3fa551bc6f5ee5890af1040415e61ecd5d46201
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SPRY3 ADAMTS2 SCML2 GNB3 MUC5AC	2.02e-05	137	107	5	25b5370b63644351efddb8749ef174beca0581cd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 M1AP UMODL1 RERGL FBN3	2.56e-05	144	107	5	cc11cce43d1af8ac63140d05faf215ae9a10cde1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 MYLK2 TMEFF2 LRRC7 PLCE1	3.53e-05	154	107	5	30cb4bb297fa815adb829f3b5cafca56fcbcb810
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 MYLK2 TMEFF2 LRRC7 PLCE1	3.53e-05	154	107	5	ade094e2947761a0a34daa8fcff3e9ea8437e4a5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 MYLK2 TMEFF2 LRRC7 PLCE1	3.53e-05	154	107	5	42bd8f88fd075a2d4edde394785decad88a2660a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 MYLK2 TMEFF2 LRRC7 PLCE1	3.53e-05	154	107	5	6425d9861148586466febd6eceae1b1f9b9a14c1
ToppCell	droplet-Liver-HEPATOCYTES-1m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCMDC2 DPF2 ITGA9 RASGRP1 UMODL1	3.87e-05	157	107	5	b527e88382c8d21188a0f222b3302523e8816dfc
ToppCell	COVID_non-vent-Myeloid-Monocytic-SC_&_Eosinophil\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	3.99e-05	158	107	5	0d4fe87fc7901dd5f9c004e91708a03cafdb4ad9
ToppCell	10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-HSC/MPP\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CYTL1 CRYGD ARHGAP20 ATP2A1 HSD17B8	4.50e-05	162	107	5	e73c644ce1db34f1d390878954e86fa0b3a455a1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 ITGA9 WDR76 CCDC85A FBXL7	4.91e-05	165	107	5	6a621b300442c52adfc15b61d3a6d3a3cb00099f
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	ADGRB3 CYTL1 CRYGD FBN1 MALRD1	4.91e-05	165	107	5	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	NS-critical-d_0-4-Epithelial-unknown_epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KNTC1 ZNF555 BACH2 FBXL7 SHOC1	5.05e-05	166	107	5	dd02bbe4af609c6348dc92417254f4740f2900a8
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_Erythro-Mega\|bone_marrow / Manually curated celltypes from each tissue	CYTL1 ITGA9 CRYGD FBN1 MALRD1	5.05e-05	166	107	5	a853005a5587d42daecdf2e23a93109919021a4f
ToppCell	mild_COVID-19-HSPC\|mild_COVID-19 / disease group, cell group and cell class (v2)	MCMDC2 CYTL1 CRYGD CLIP3 FBN1	5.35e-05	168	107	5	90b33962adb77d8326dee403712118398b4d1315
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-cDC1\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRRK2 LRRK1 VMO1 CLCN4 ARHGAP20	5.50e-05	169	107	5	da3485d77bb7876fad4f166f6099e681b27457ae
ToppCell	3'_v3-blood-Hematopoietic_progenitors-HSC-MPP\|blood / Manually curated celltypes from each tissue	CYTL1 ITGA9 CRYGD CLIP3 SCML2	5.65e-05	170	107	5	1443d7fccc81088dd42dcbb9361e269872542274
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	KNTC1 ADAMTS2 ITGA9 VMO1 MUC5AC	5.98e-05	172	107	5	f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	CTTNBP2 CCDC85A MYO3A FBXL7 PLCE1	5.98e-05	172	107	5	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	severe_COVID-19-HSPC\|severe_COVID-19 / disease group, cell group and cell class (v2)	CYTL1 ITGA9 CRYGD CLIP3 FBN1	6.31e-05	174	107	5	6d35bacf073537b272ff821e604c899fb9ce6a7c
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_MEMP\|lymph-node_spleen / Manually curated celltypes from each tissue	SPTBN2 CYTL1 CRYGD FBN1 MALRD1	6.66e-05	176	107	5	23a8ec42ebd42c539865a12d09773af90f3f8848
ToppCell	3'_v3-blood-Hematopoietic_progenitors\|blood / Manually curated celltypes from each tissue	CYTL1 ITGA9 CRYGD CLIP3 SCML2	6.84e-05	177	107	5	22c77077951889e63489abfabf90900655655c82
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CTTNBP2 BACH2 ADGRB3 FBXL7 GNB3	6.84e-05	177	107	5	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	severe_COVID-19-HSPC\|World / disease group, cell group and cell class (v2)	CYTL1 ITGA9 CRYGD CLIP3 FBN1	6.84e-05	177	107	5	289f6aed6f054b04b01659434d8c8b467d1bf5dd
ToppCell	COVID-19_Mild-Hematopoietic_SC-HSPC\|COVID-19_Mild / Disease group, lineage and cell class	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.22e-05	179	107	5	19fcf48f5e02e4cb2b328efb4502f337e1282f72
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.22e-05	179	107	5	4bb2debfc9e9f258cd38e797ef160bd440aad6af
ToppCell	PBMC-Mild-Hematopoietic-HSPC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.22e-05	179	107	5	2f690f933bf6b99abeb31766e0b22bdbe36c1ba0
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.22e-05	179	107	5	3e2c937369b8190fd5d5a31689d029e6e89fb5e2
ToppCell	COVID-19_Mild-Hematopoietic_SC\|COVID-19_Mild / Disease group, lineage and cell class	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.22e-05	179	107	5	50a073166e34bcfa52a62c4dafb3aef724e0fa8e
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BACH2 ADGRB3 ITGA9 FBN1 FBXL7	7.41e-05	180	107	5	01f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAND2 SHMT2 LEPR M1AP SCML2	7.61e-05	181	107	5	274c0b768925cd5804483303f8c5ebd17a534c41
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.61e-05	181	107	5	e7f7b519c2a01c15f26df11ec9b434c0d1630c7a
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.61e-05	181	107	5	54a19cf6a3b752e2391feb8b316bebee0e602d17
ToppCell	PBMC-Mild-Hematopoietic-HSPC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.61e-05	181	107	5	5b84625b1d3737708001b64f6da9360330d39a27
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.81e-05	182	107	5	6497eeafb2b137e70261ec0314782831892a940d
ToppCell	Control-Hematopoietic_SC-HSPC\|Control / Disease group, lineage and cell class	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.81e-05	182	107	5	14e347c0e6444410f1948851407bb18c706569f4
ToppCell	Control-Hematopoietic_SC\|Control / Disease group, lineage and cell class	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.81e-05	182	107	5	43243c6bae2ac7fa3fd1f193a17f61ee4d938ea9
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.81e-05	182	107	5	d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCell	PBMC-Control-Hematopoietic-HSPC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.81e-05	182	107	5	bd1626261803324084fafca2f6665b50854e7fae
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.81e-05	182	107	5	2a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCell	PBMC-Control-Hematopoietic-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.81e-05	182	107	5	918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	7.81e-05	182	107	5	0d9b8c900da8cbae9cde72aecd4026b1ac2bbd67
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	CTTNBP2 ECT2L TMEFF2 FBXL7 HSPA14	7.81e-05	182	107	5	ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCell	PBMC-Severe-Hematopoietic-HSPC-HSPC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CYTL1 ITGA9 CRYGD FBN1 MALRD1	8.22e-05	184	107	5	51d0447699e3b8f01abbde83f26b748bc9f3c723
ToppCell	PBMC-Severe-Hematopoietic-HSPC-HSPC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CYTL1 ITGA9 CRYGD FBN1 MALRD1	8.22e-05	184	107	5	f7b0bb45a9055ab34e98b251217f6ec38c75ca22
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SESN3 HELB RASGRP1 IGF1R SORL1	8.22e-05	184	107	5	5350b58aa9979631228835d11eb45ddf81d08bff
ToppCell	PBMC-Severe-Hematopoietic-HSPC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CYTL1 ITGA9 CRYGD FBN1 MALRD1	8.22e-05	184	107	5	26edbf84216538b80f1ffcc079ee6e385a71fbf9
ToppCell	facs-Skin-nan-24m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 LEPR CLIP3 FBN1 ARHGAP20	8.43e-05	185	107	5	8433a337625ff8398520e223ef92bf9bb0beb14c
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 ZNF407 DIS3 CMTR2 ZNF574	8.43e-05	185	107	5	efcfbf5a48b3ea9a425183e5c2eec6a9585415a0
ToppCell	facs-Skin-nan-24m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 LEPR CLIP3 FBN1 ARHGAP20	8.43e-05	185	107	5	049d793d043d5d434f143025de49dd210d18756c
ToppCell	facs-Skin-nan-24m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 LEPR CLIP3 FBN1 ARHGAP20	8.43e-05	185	107	5	63200c42565eea596f9b00728e70e544b8d50a7f
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 ZNF407 DIS3 CMTR2 ZNF574	8.43e-05	185	107	5	642088ace9230d38b0579853c54ff4dd8b5d5df4
ToppCell	COVID-19_Moderate-HSPC\|COVID-19_Moderate / disease group, cell group and cell class	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	8.43e-05	185	107	5	cacc6ab5f26f6c803894567fb838ea06eaa7efe5
ToppCell	343B-Fibroblasts-Fibroblast-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	SESN3 ITGA9 FBN1 USP35 ARHGAP20	8.65e-05	186	107	5	1bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CTTNBP2 LRRK2 RASGRP1 PKHD1 LYG1	8.65e-05	186	107	5	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADAMTS2 LRRK2 LRP1B TLN1 PKHD1	8.65e-05	186	107	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	343B-Fibroblasts-Fibroblast-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	SESN3 ITGA9 FBN1 USP35 ARHGAP20	8.65e-05	186	107	5	59db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	CTTNBP2 ADGRB3 CYTL1 ARHGAP20 FBN3	8.87e-05	187	107	5	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	Pericytes-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	RAB9B CAND2 BACH2 CLIP3 RERGL	8.87e-05	187	107	5	35f25780d113f60bf4c13749013c09612ee4ff41
ToppCell	normal-na-Hematopoietic-progenitor_cell\|normal / PBMC cell types (v2) per disease, treatment status, and sex	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	9.09e-05	188	107	5	013162466a3334b6967c0cb670c8577d809b1396
ToppCell	normal-na-Hematopoietic-progenitor_cell-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	9.09e-05	188	107	5	be25371e6459504b5f0c9ece3a0fe8f80c7824ca
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 M1AP RASGRP1 SHOC1 FBN3	9.09e-05	188	107	5	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BACH2 HELB TG RASGRP1 SORL1	9.32e-05	189	107	5	df30478b288084a1bd48f660409dcc784040897c
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	BACH2 ADGRB3 ITGA9 FBN1 FBXL7	9.32e-05	189	107	5	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	COVID-19_Severe-HSPC\|World / disease group, cell group and cell class	CYTL1 ITGA9 CRYGD FBN1 MALRD1	9.32e-05	189	107	5	555c0b13f1508b9e3712b36d77144e73e828bc76
ToppCell	Healthy-HSPC\|Healthy / disease group, cell group and cell class	SPTBN2 CYTL1 ITGA9 CRYGD FBN1	9.32e-05	189	107	5	214b225effc40ca1b83dd8052f2a7b80b65d4938
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 PEG3 LEPR CLIP3 FBN1	9.80e-05	191	107	5	4b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CASR LRP1B LEPR SYT16 PKHD1	9.80e-05	191	107	5	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 PEG3 LEPR CLIP3 FBN1	9.80e-05	191	107	5	75d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	LRRK2 TMEFF2 MALRD1 PKHD1 FBN3	9.80e-05	191	107	5	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	droplet-Kidney-nan-3m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 TMEFF2 CLIP3 FBN1 ARHGAP20	9.80e-05	191	107	5	d1205aab0937f2becfcd239610e9b78fb8a0c886
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 TMEFF2 CLIP3 FBN1 ARHGAP20	1.00e-04	192	107	5	853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LRRK2 TMEFF2 MALRD1 PKHD1 FBN3	1.00e-04	192	107	5	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CFuPNs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	CTTNBP2 BACH2 ADGRB3 CLCN4 ARHGAP20	1.00e-04	192	107	5	a8841ebd879f1c344ab4246fdef77044170f644d
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 TMEFF2 CLIP3 FBN1 ARHGAP20	1.00e-04	192	107	5	d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 TMEFF2 CLIP3 FBN1 ARHGAP20	1.00e-04	192	107	5	49281626ecad0456fdbded2378b7028d7b589686
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	BACH2 SESN3 MCMDC2 IGF1R SORL1	1.03e-04	193	107	5	4e78ddc96d8e403a21c4a303b1f26512d2ac91e8
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MYT1L BACH2 CLIP3 MYO3A ZER1	1.03e-04	193	107	5	088c8b1e968f5356502347eaabdc6b1b1d4befd0
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-22\|World / Primary Cells by Cluster	MASP1 CTTNBP2 LRRC7 ARHGAP21 SORL1	1.03e-04	193	107	5	3b927d4b8ecb21a408424ef91a23746c21741f49
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 CYTL1 ITGA9 CCDC85A FBXL7	1.03e-04	193	107	5	287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Basophilic_Erythroblast\|World / Lineage, cell class and subclass	CYTL1 LEPR CRYGD FBN1 GNB3	1.05e-04	194	107	5	f054d78429364622d402ce1d9bf6ad13a1a1bf7e
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTS2 ADGRB3 FBN1 ARHGAP20 PLCE1	1.05e-04	194	107	5	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS2 ADGRB3 FBN1 LRRC7 ARHGAP20	1.05e-04	194	107	5	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	GIMAP5 BACH2 SESN3 MCMDC2 IGF1R	1.05e-04	194	107	5	a7bfc535546d3c1a4e0cbcfeb7da816b34303350
Drug	Orlistat; Up 200; 10uM; MCF7; HT_HG-U133A	FTCD LEPR TBC1D17 FBN1 CLCN4 CDK13 ZER1 ATP2A1	3.69e-06	195	106	8	6415_UP
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN3	3.47e-05	3	101	2	DOID:65 (implicated_via_orthology)
Disease	cortical thickness	CTTNBP2 ADAMTS2 SPTBN2 TG IGF1R FBN1 FBXL7 MALRD1 UMODL1 PKHD1 USP35 ARHGAP21 PLCE1	1.10e-04	1113	101	13	EFO_0004840
Disease	osteopetrosis (implicated_via_orthology)	LRRK1 CLCN4	2.41e-04	7	101	2	DOID:13533 (implicated_via_orthology)
Disease	descending aortic diameter	MASP1 STAT6 FBN1 PLCE1	2.42e-04	88	101	4	EFO_0021788
Disease	Alzheimer disease	DMXL1 FANCD2 FBXL7 RERGL PKHD1 CACNA1G ARHGAP20 SORL1	2.67e-04	485	101	8	MONDO_0004975
Disease	Developmental delay (disorder)	SPTBN2 IGF1R GNB1	2.78e-04	37	101	3	C0424605
Disease	waist-hip ratio	KNTC1 CAND2 ADAMTS2 ZNF407 CYTL1 KBTBD2 ITGA9 MYLK2 IGF1R ALG9 ATP2A1 ARHGAP21 PLCE1	2.83e-04	1226	101	13	EFO_0004343
Disease	corpus callosum volume measurement	CTTNBP2 TG FBXL7 TLN1	3.94e-04	100	101	4	EFO_0010299
Disease	central corneal thickness	MASP1 ADAMTS2 ZNF407 LRRK1 FBN1 DPF3	6.92e-04	309	101	6	EFO_0005213
Disease	lung adenocarcinoma, family history of lung cancer	FBXL7 MALRD1 RERGL	7.19e-04	51	101	3	EFO_0000571, EFO_0006953
Disease	cesarean section, intelligence	BACH2 MYLK2	7.49e-04	12	101	2	EFO_0004337, EFO_0009636
Disease	idiopathic osteonecrosis of the femoral head	SPRY3 CTTNBP2 UMODL1	7.62e-04	52	101	3	EFO_1001930
Disease	prostate carcinoma (is_implicated_in)	STAT6 CDK13	8.83e-04	13	101	2	DOID:10286 (is_implicated_in)
Disease	lysophosphatidylcholine 15:0 measurement	LRP1B PKHD1	1.03e-03	14	101	2	EFO_0020941
Disease	adverse effect, response to xenobiotic stimulus	LRP1B TMEFF2 FBXL7	1.10e-03	59	101	3	EFO_0009658, GO_0009410
Disease	Global developmental delay	SPTBN2 INTS1 IGF1R GNB1	1.15e-03	133	101	4	C0557874
Disease	serum gamma-glutamyl transferase measurement	ZSWIM5 ITGA9 VMO1 IGF1R TLN1 RP1L1 PKHD1 ZER1 ARHGAP21 PLCE1	1.17e-03	914	101	10	EFO_0004532
Disease	quinate measurement	LRRK2 LEPR	1.18e-03	15	101	2	EFO_0021167
Disease	Graves' disease (is_marker_for)	TG IGF1R	1.18e-03	15	101	2	DOID:12361 (is_marker_for)
Disease	risk-taking behaviour	MYT1L BACH2 TMEFF2 IGF1R RP1L1 CACNA1G ATP2A1 CMTR2 SORL1	1.25e-03	764	101	9	EFO_0008579
Disease	Inborn Errors of Metabolism	LEPR MMUT	1.53e-03	17	101	2	C0025521
Disease	renal fibrosis (implicated_via_orthology)	LEPR STAT6	1.53e-03	17	101	2	DOID:0050855 (implicated_via_orthology)
Disease	platelet crit	BACH2 LRRK2 ZNF407 LEPR MYLK2 IGF1R CDK13 TLN1 PLCE1 SORL1	1.58e-03	952	101	10	EFO_0007985
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	LRRK2 VMO1 LRP1B MYO3A	1.70e-03	148	101	4	C0279702
Disease	glaucoma	CTTNBP2 LRP1B PKHD1 PLCE1	1.97e-03	154	101	4	MONDO_0005041
Disease	Paroxysmal atrial fibrillation	CAND2 IGF1R DPF3 SORL1	2.06e-03	156	101	4	C0235480
Disease	prostate cancer (is_marker_for)	TMEFF2 STAT6 IGF1R CDK13	2.06e-03	156	101	4	DOID:10283 (is_marker_for)
Disease	familial atrial fibrillation	CAND2 IGF1R DPF3 SORL1	2.06e-03	156	101	4	C3468561
Disease	Persistent atrial fibrillation	CAND2 IGF1R DPF3 SORL1	2.06e-03	156	101	4	C2585653
Disease	behavioural disinhibition measurement	MASP1 CTTNBP2 ADGRB3	2.20e-03	75	101	3	EFO_0006946
Disease	Atrial Fibrillation	CAND2 IGF1R DPF3 SORL1	2.26e-03	160	101	4	C0004238
Disease	Ovarian Serous Adenocarcinoma	LRRK2 MYO3A	2.80e-03	23	101	2	C1335177
Disease	Immunologic Deficiency Syndromes	LEPR RASGRP1	2.80e-03	23	101	2	C0021051
Disease	sudden cardiac arrest	TMEFF2 PKHD1 PLCE1	2.93e-03	83	101	3	EFO_0004278

Protein segments in the cluster

Peptide	Gene	Start	Entry
EELNACSGRELCANL	UMODL1	271	Q5DID0
CRALCEDVASLQSFD	AMER3	231	Q8N944
ELLDNFSCLSQEVCR	BACH2	701	Q9BYV9
CLCDRLSTFAILAQQ	ADGRB3	851	O60242
CAALLSNISDCDETF	ALG9	71	Q9H6U8
DSLNLDEFCNCSEHI	CASR	121	P41180
IDSCIQSFDADGNLC	RASGRP1	66	O95267
FSELCSLTECLQDEQ	CMTR2	556	Q8IYT2
QLRADDCFCASRKLD	BTBD11	546	A6QL63
AQLHCCDEEISFSLR	ECT2L	791	Q008S8
LFNDCGALESSQLCD	CLCN4	401	P51793
DLDECTSRQHNCQFL	FBN3	2446	Q75N90
EVIALQRTCDFCSDA	DMXL1	2066	Q9Y485
RCTAEQALQCEFLRD	CDK13	986	Q14004
DDFVEDLLCCLNLNS	FAM200A	166	Q8TCP9
RLECLLNNNKNSDFC	DCAF7	106	P61962
ICALCNDSSLDFNEA	ATP2A1	416	O14983
DFQLCSRQDCPDSLA	ADAMTS2	606	O95450
DRCSALLELQRFNLC	C17orf113	146	A0A1B0GUU1
DCCLLTFSVDDRQSF	RAB9B	81	Q9NP90
RQCRGLELIASENFC	SHMT2	66	P34897
VNLADCLCNEDLESR	LTN1	746	O94822
GNICRADEFLCNNSL	LRP1B	3671	Q9NZR2
DICTNLCEALQNFFS	M1AP	36	Q8TC57
ATIRNDFLCNLCASS	MCMDC2	176	Q4G0Z9
DFLCNLCASSLQEDR	MCMDC2	181	Q4G0Z9
EECCRNLAFSLALRS	INTS1	2096	Q8N201
GNLSLLEEFDCSCNE	LRRC7	296	Q96NW7
RDLLEEACDQCASQL	LRRK1	71	Q38SD2
LCGTSENDDQLLFCD	DPF3	321	Q92784
CINFDFNTIRCQDLS	KCTD20	206	Q7Z5Y7
KDCLQNSLCEAEDRF	KRT38	341	O76015
CVDRDFCANILSAES	IGF1R	276	P08069
GQALCLTAREEDCFQ	MYLK2	241	Q9H1R3
ENCVRLLSFADLFSC	KBTBD2	131	Q8IY47
ANELRDIDALSQKCC	LRRK2	991	Q5S007
FRSEQDRNCSLCADN	LEPR	91	P48357
CSTFQLDCDAVLQLF	KNTC1	1451	P50748
LSCCRFLDDNQIITS	GNB2	146	P62879
LSCCRFLDDNNIVTS	GNB3	146	P16520
CRQDLCFCEDTDLLS	MUC5AC	291	P98088
CLANLASRCGLQDDF	MSLNL	96	Q96KJ4
FCRRDLVFLLDDCNA	CYTL1	106	Q9NRR1
CDVCGQLFNDRLSLA	PEG3	1566	Q9GZU2
ANTDNCSLKDLVREC	GIMAP5	166	Q96F15
RNECKLSDQRAALSC	PLA2G4E	491	Q3MJ16
FERNCRSEDCAADLQ	ITGA9	616	Q13797
RFDATDEELRLCQAC	MALRD1	256	Q5VYJ5
TEDCSCLQDRFRFNE	CRYGD	106	P07320
DIACDSQRCRILQAF	CACNA1G	106	O43497
LSCCRFLDDNQIVTS	GNB1	146	P62873
SDDLECENTICALNI	CTTNBP2	986	Q8WZ74
SDTGLECLALNCFNL	FBXL7	416	Q9UJT9
TCTDLDECSENLNLC	FBN1	1401	P35555
AARCLLEQVQACFSR	HSD17B8	81	Q92506
DNQELRDLCCFLDDD	CCDC85A	101	Q96PX6
SQDLSCDFCNDVLAR	LYG1	171	Q8N1E2
TDNRTCRVECSDNLF	MASP1	176	P48740
LQCLRAFENCSEDLQ	CBR3	141	O75828
RCLAFVDDVRCSNQS	KANSL2	301	Q9H9L4
LLVDLCLDDLSCNQN	AHCTF1	166	Q8WYP5
LAENTSCDFLPRFQC	ATRIP	571	Q8WXE1
DIASENSISRLLFCC	CLIP3	521	Q96DZ5
FCNLDDDELRESCLQ	CAND2	266	O75155
FIAFRRQDCDLINDC	HELB	741	Q8NG08
QELARCGNLACRSDL	FTCD	466	O95954
DEDSFRNCLLSCERL	FANCD2	106	Q9BXW9
FDCNVSRARFELLCS	HSPA14	291	Q0VDF9
CDTRENASDISCFQL	ARHGAP20	566	Q9P2F6
ECSLDCHRAELSQLF	TAF5	226	Q15542
ICDLDTQFRCQESGT	SORL1	1116	Q92673
LALENRCQFCELSAA	RERGL	141	Q9H628
RCQFCELSAAEQSLE	RERGL	146	Q9H628
SLCQSVLEDFNLCLF	SMG5	311	Q9UPR3
LEVDHFSCCNSDLQD	SYT16	86	Q17RD7
DRENDLFLCDTNTCK	TMEFF2	61	Q9UIK5
FCTLSENLILDDCGN	PLCE1	201	Q9P212
ASDSQCQAFCLLEAA	SHOC1	586	Q5VXU9
LGDDTALNDARLFCC	VMO1	186	Q7Z5L0
NFDLINCVAIRTCSD	PKHD1	2476	P08F94
CSFVILCTDDRNLRN	SWT1	501	Q5T5J6
SNLCSLKCDVDRLAF	DIS3	546	Q9Y2L1
NQRCLCSAESLLDYG	SPRY3	171	O43610
CDLELINVCNENSLF	CLTC	926	Q00610
LLCDFLDSQDSGSLC	TBC1D17	476	Q9HA65
CLFLTLTEACRLNDD	ZSWIM5	611	Q9P217
CKECASFSSLENLQR	ZNF441	171	Q8N8Z8
ALCTDFCLRNLDGTL	ZER1	11	Q7Z7L7
ERLCESNDQCGEALS	ZNF555	111	Q8NEP9
DANRAELFAQSCCAL	SPTBN2	1381	O15020
FLNARACACATNEDE	RP1L1	1261	Q8IWN7
EACRSCLEQAKLLFS	DNTTIP1	116	Q9H147
LRFLENFCHSLQCDN	SCML2	446	Q9UQR0
LISVNNFCVCDLAND	SESN3	226	P58005
CETAIAALNSCLRDL	TLN1	1661	Q9Y490
DAFCCNLASALLSDT	STAT6	46	P42226
LCCLNVSSREEAFTD	USP35	581	Q9P2H5
TQELFCSACDQLFLS	ZNF574	306	Q6ZN55
DELERSFDCCGLFNL	TSPAN31	121	Q12999
AINSDLCCSSQDLEF	PPP1R3D	136	O95685
NICGTSENDDQLLFC	DPF2	331	Q92785
SENDDQLLFCDDCDR	DPF2	336	Q92785
ADCNLRIFDSSCISS	WDR76	516	Q9H967
QCCSFISLDEINLRD	ZNF407	591	Q9C0G0
ASSDAICRDFLRNVC	ZC3H10	36	Q96K80
LTTSDCECLFQAEDR	ARHGAP21	1011	Q5T5U3
SNFSAVRDLCLSECS	TG	2121	P01266
ECKQCDQAFSRLSSL	ZNF669	391	Q96BR6
ALENCASLLCIRADE	MYO3A	631	Q8NEV4
DQALAERCLAALTEC	MMUT	526	P22033
EVCLSSLECLRNQCF	MYT1L	321	Q9UL68