Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontelomerase RNA binding

SMG7 SNRPD3

4.80e-0425262GO:0070034
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

SRCAP CHD5

1.06e-0337262GO:0140658
GeneOntologyMolecularFunctionamino acid binding

CAD TAT

4.05e-0373262GO:0016597
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

RAG1 SRCAP CHD5

4.64e-03262263GO:0140097
GeneOntologyMolecularFunctionhistone binding

RAG1 SRCAP CHD5

4.79e-03265263GO:0042393
DomainSNF2_N

SRCAP CHD5

8.32e-0432252PF00176
DomainSNF2_N

SRCAP CHD5

8.32e-0432252IPR000330
DomainZinc_finger_PHD-type_CS

INTS12 CHD5

3.40e-0365252IPR019786
DomainPHD

INTS12 CHD5

4.50e-0375252PF00628
DomainZnf_PHD-finger

INTS12 CHD5

4.98e-0379252IPR019787
DomainPHD

INTS12 CHD5

6.27e-0389252SM00249
DomainZnf_PHD

INTS12 CHD5

6.55e-0391252IPR001965
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

CCP110 CAD INTS12 SMG7 SRCAP UCHL1

3.93e-0658826638580884
Pubmed

Human transcription factor protein interaction networks.

WBP11 CAD INTS12 SMG7 GTPBP1 SRCAP ZHX1 CHD5

6.42e-06142926835140242
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

WBP11 URB1 CAD SRCAP SNRPD3 UCHL1 AHNAK

7.57e-06102426724711643
Pubmed

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

WBP11 CAD SMG7 SRCAP SNRPD3

2.01e-0545726532968282
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

OSBPL8 URB1 SMG7 CHD5

2.28e-0522526412168954
Pubmed

Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation.

RAG1 UCHL1

2.41e-051026231042473
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

WBP11 C9orf43 GPR171 INTS12 SRCAP AHNAK CHD5

6.82e-05144226735575683
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

URB1 SEC31A SMG7 GTPBP1 AHNAK

1.76e-0472426536232890
Pubmed

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

CAD HOOK2 ERVK-21 AHNAK

1.77e-0438226437249651
Pubmed

Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.

CCP110 CAD

1.86e-042726235709258
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

WBP11 SEC31A SNRPD3 AHNAK

2.09e-0439926435987950
Pubmed

Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.

CCP110 SMG7

3.72e-043826236674791
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

CCP110 WBP11 C9orf43 AHNAK

3.86e-0446926427634302
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

URB1 CAD SEC31A SRCAP SNRPD3 AHNAK

4.04e-04135326629467282
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

OSBPL8 WBP11 GTPBP1 SNRPD3 UCHL1 AHNAK

4.33e-04137126636244648
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

CAD SEC31A SNRPD3 AHNAK

4.69e-0449426426831064
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

OSBPL8 GTPBP1 SNRPD3 AHNAK

4.84e-0449826436634849
Pubmed

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

CAD GTPBP1

4.99e-044426226471122
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

OSBPL8 WBP11 CAD SEC31A SNRPD3 AHNAK

5.12e-04141526628515276
Pubmed

Aire's partners in the molecular control of immunological tolerance.

RAG1 SNRPD3

5.22e-044526220085707
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

URB1 CAD SEC31A GTPBP1 SNRPD3 UCHL1

5.32e-04142526630948266
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

OSBPL8 URB1 CAD HOOK2 SNRPD3 AHNAK

5.62e-04144026630833792
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

SMG7 SRCAP SNRPD3 UCHL1 AHNAK

5.68e-0493426533916271
Pubmed

New insights on the functional role of URG7 in the cellular response to ER stress.

SEC31A SNRPD3

5.69e-044726229704455
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

OSBPL8 SEC31A GTPBP1 UCHL1 AHNAK

6.20e-0495226538569033
Pubmed

High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays.

CCP110 AHNAK

6.44e-045026229560723
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

CAD SMG7 SRCAP AHNAK

6.97e-0454926438280479
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

CCP110 CAD AHNAK

6.97e-0423426336243803
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

CAD SNRPD3 AHNAK

7.06e-0423526330258100
InteractionFBXO42 interactions

CCP110 CAD INTS12 SMG7 UCHL1

1.45e-05259255int:FBXO42
InteractionATG12 interactions

WBP11 CAD SMG7 SRCAP SNRPD3

2.76e-05296255int:ATG12
GeneFamilyPHD finger proteins

INTS12 CHD5

1.57e-039012288
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PCDH11X WBP11

6.16e-03181122694
CoexpressionMARSON_BOUND_BY_FOXP3_STIMULATED

OSBPL8 WBP11 GPR171 CAD HOOK2 INTS12 SMG7 GTPBP1

2.22e-061024248M1742
CoexpressionMARSON_BOUND_BY_FOXP3_STIMULATED

OSBPL8 WBP11 GPR171 CAD HOOK2 INTS12 SMG7 GTPBP1

3.12e-061072248MM1031
CoexpressionGSE21063_3H_VS_16H_ANTI_IGM_STIM_NFATC1_KOBCELL_UP

OSBPL8 URB1 SRCAP AHNAK

3.04e-05199244M8255
CoexpressionGSE25890_CTRL_VS_IL33_IL7_TREATED_NUOCYTES_DN

OSBPL8 CCP110 URB1 AHNAK

3.10e-05200244M7356
Diseasemean reticulocyte volume

CAD HOOK2 GTPBP1 C1orf105

3.13e-03799234EFO_0010701
DiseaseColorectal Carcinoma

PCDH11X CAD CHD5

1.67e-02702233C0009402

Protein segments in the cluster

PeptideGeneStartEntry
LIAKKNPKIPMSKMM

CHD5

171

Q8TDI0
PMNSKPQQIKMQSTK

GTPBP1

581

O00178
FKMPEMNIKVPKISM

AHNAK

806

Q09666
NLKMPKMKMPKFSVS

AHNAK

3471

Q09666
FKMPEMNIKAPKISM

AHNAK

3861

Q09666
RKKMNLKPIMRMNGN

RAG1

841

P15918
KMNKMVTSEQMKLPS

ERVK-21

26

P61571
MKRMAQKTQKPPQKP

INTS12

216

Q96CB8
DNMKVKPNPNKTMIS

TAT

61

P17735
KARMVMQTMEPKQRP

HOOK2

606

Q96ED9
NKLKPGQMEMLKLTM

NXF5

96

Q9H1B4
MVPNMMIPIKDIKEK

GPR171

146

O14626
TPNPENRQMIMMKKK

PCDH11X

856

Q9BZA7
MVSVPKMKHKPTRQQ

OSBPL8

776

Q9BZF1
PEMKIKLAMMKKNLP

C9orf43

231

Q8TAL5
KMLRQMDKMKSPRVA

CCP110

896

O43303
KMNKMVTSEQMKLPS

ERVK-21

26

P61565
QPPVMQQQPLEKKMK

SMG7

836

Q92540
KMKVNRMLQPVPKQE

SRCAP

991

Q6ZRS2
MKMLKDKNKPVMPAR

URB1

2011

O60287
CQEMKMVQPRTMKIP

C1orf105

86

O95561
GMKMKLNPQNSEVMP

MIPEP

341

Q99797
TPIMKMMKNKVENKR

ZHX1

181

Q9UKY1
RHSQKKVPMMPKEMV

TEX13C

481

A0A0J9YWL9
MLKNAPMLKSMKNKN

SNRPD3

76

P62318
KKKMVVMHPMPRVNE

CAD

2176

P27708
KKNMKELTPLQAMML

WBP11

321

Q9Y2W2
LNRVPKKKKMPENFM

SEC31A

1001

O94979
MQLKPMEINPEMLNK

UCHL1

1

P09936