Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate phosphatase activity

MTMR1 OCRL PIKFYVE MTM1

7.94e-06161674GO:0106018
GeneOntologyMolecularFunctionhelicase activity

EIF4A3 DDX42 SRCAP DICER1 DDX27 DQX1 EIF4A1 ASCC3

5.62e-051581678GO:0004386
GeneOntologyMolecularFunctionATP-dependent activity

APPBP2 ATP7B EIF4A3 KIF1B DDX42 DNAH2 SRCAP DICER1 DDX27 DQX1 EIF4A1 ABCB11 KIFC3 ASCC3 MYO15A DNAH6

5.98e-0561416716GO:0140657
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate phosphatase activity

MTMR1 OCRL PIKFYVE MTM1

7.13e-05271674GO:0034593
GeneOntologyMolecularFunctionphosphatidylinositol phosphate phosphatase activity

MTMR1 OCRL PIKFYVE MTM1

1.09e-04301674GO:0052866
GeneOntologyMolecularFunctionsuccinate-CoA ligase (ADP-forming) activity

SUCLG2 SUCLA2

2.07e-0431672GO:0004775
GeneOntologyMolecularFunctionsuccinate-CoA ligase activity

SUCLG2 SUCLA2

2.07e-0431672GO:0004774
GeneOntologyMolecularFunctionprotein serine kinase activity

RIPK1 KALRN CDK12 RIPK4 LRRK1 GSK3A GSK3B PIKFYVE STK38L DCLK1 SBK3

2.49e-0436316711GO:0106310
GeneOntologyMolecularFunctionmicrotubule motor activity

APPBP2 KIF1B DNAH2 KIFC3 DNAH6

3.01e-04701675GO:0003777
GeneOntologyMolecularFunctionATP hydrolysis activity

ATP7B EIF4A3 KIF1B DDX42 DNAH2 SRCAP DDX27 DQX1 EIF4A1 ABCB11 ASCC3 DNAH6

3.48e-0444116712GO:0016887
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH2 KIFC3 DNAH6

4.27e-04181673GO:0008569
GeneOntologyMolecularFunctioncytoskeletal motor activity

APPBP2 KIF1B DNAH2 KIFC3 MYO15A DNAH6

4.76e-041181676GO:0003774
GeneOntologyMolecularFunctionkinase activity

EPHA6 RIPK1 KALRN CDK12 RIPK4 LRRK1 PRAG1 GSK3A GSK3B PIKFYVE PALS1 PIK3R6 PIK3CD STK38L DCLK1 SBK3

6.96e-0476416716GO:0016301
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

EPHA6 RIPK1 KALRN CDK12 RIPK4 LRRK1 PRAG1 GSK3A GSK3B PIKFYVE PIK3R6 PIK3CD STK38L DCLK1 SBK3

9.25e-0470916715GO:0016773
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

OCRL PIKFYVE

1.02e-0361672GO:0043813
GeneOntologyMolecularFunctionnetrin receptor activity

UNC5B DCC

1.02e-0361672GO:0005042
GeneOntologyMolecularFunctionphosphatidylinositol kinase activity

PIKFYVE PIK3R6 PIK3CD

1.30e-03261673GO:0052742
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

RIPK1 KALRN CDK12 RIPK4 LRRK1 GSK3A GSK3B PIKFYVE STK38L DCLK1 SBK3

1.36e-0344616711GO:0004674
GeneOntologyMolecularFunction1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity

PIK3R6 PIK3CD

1.42e-0371672GO:0046934
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH2 HOOK3 DNAH6

1.61e-03281673GO:0051959
GeneOntologyMolecularFunctionprotein kinase activity

EPHA6 RIPK1 KALRN CDK12 RIPK4 LRRK1 PRAG1 GSK3A GSK3B PIKFYVE STK38L DCLK1 SBK3

1.64e-0360016713GO:0004672
GeneOntologyBiologicalProcessphosphatidylinositol biosynthetic process

MTMR1 OCRL EFR3A PIKFYVE VAC14 PIK3CD PIK3R2 MTM1

1.12e-051321658GO:0006661
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex, class I

PIK3R6 PIK3CD PIK3R2

4.13e-0591683GO:0097651
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex, class IA

PIK3R6 PIK3CD PIK3R2

4.13e-0591683GO:0005943
GeneOntologyCellularComponentsuccinate-CoA ligase complex

SUCLG2 SUCLA2

1.92e-0431682GO:0042709
DomainATP-grasp_succ-CoA_synth-type

ACLY SUCLG2 SUCLA2

6.53e-0731633IPR013650
DomainSucc-CoA_synthase_bsu_CS

ACLY SUCLG2 SUCLA2

6.53e-0731633IPR017866
DomainATP-grasp_2

ACLY SUCLG2 SUCLA2

6.53e-0731633PF08442
DomainSUCCINYL_COA_LIG_3

ACLY SUCLG2 SUCLA2

6.53e-0731633PS01217
DomainCoA_ligase

ACLY SUCLG2 SUCLA2

2.59e-0641633IPR005811
DomainSuccinyl-CoA_synth-like

ACLY SUCLG2 SUCLA2

2.59e-0641633IPR016102
DomainLigase_CoA

ACLY SUCLG2 SUCLA2

2.59e-0641633PF00549
Domain-

ACLY SUCLG2 SUCLA2

2.59e-06416333.40.50.261
DomainHelicase_C

EIF4A3 DDX42 SRCAP DICER1 DDX27 DQX1 EIF4A1 ASCC3

4.76e-061081638IPR001650
DomainHELICASE_CTER

EIF4A3 DDX42 SRCAP DICER1 DDX27 DQX1 EIF4A1 ASCC3

5.10e-061091638PS51194
DomainHELICASE_ATP_BIND_1

EIF4A3 DDX42 SRCAP DICER1 DDX27 DQX1 EIF4A1 ASCC3

5.10e-061091638PS51192
DomainDEXDc

EIF4A3 DDX42 SRCAP DICER1 DDX27 DQX1 EIF4A1 ASCC3

5.10e-061091638SM00487
DomainHelicase_ATP-bd

EIF4A3 DDX42 SRCAP DICER1 DDX27 DQX1 EIF4A1 ASCC3

5.46e-061101638IPR014001
DomainDEAD/DEAH_box_helicase_dom

EIF4A3 DDX42 DICER1 DDX27 EIF4A1 ASCC3

4.23e-05731636IPR011545
DomainDEAD

EIF4A3 DDX42 DICER1 DDX27 EIF4A1 ASCC3

4.23e-05731636PF00270
DomainHelicase_C

EIF4A3 DDX42 SRCAP DICER1 DDX27 EIF4A1 ASCC3

4.25e-051071637PF00271
DomainHELICc

EIF4A3 DDX42 SRCAP DICER1 DDX27 EIF4A1 ASCC3

4.25e-051071637SM00490
DomainP-loop_NTPase

MTG1 NLRP12 EIF4A3 KIF1B DDX42 DNAH2 LRRK1 SRCAP DICER1 DDX27 PALS1 GSPT2 DQX1 EIF4A1 ABCB11 DLG3 KIFC3 ASCC3 MYO15A DNAH6

5.13e-0584816320IPR027417
DomainSucc_CoA_synthase_bsu

SUCLG2 SUCLA2

7.57e-0521632IPR005809
Domain-

MTG1 NLRP12 EIF4A3 DDX42 DNAH2 LRRK1 SRCAP DICER1 DDX27 PALS1 GSPT2 DQX1 EIF4A1 ABCB11 DLG3 ASCC3 MYO15A DNAH6

9.36e-05746163183.40.50.300
DomainDEAD_ATP_HELICASE

EIF4A3 DDX42 DDX27 EIF4A1

1.46e-04311634PS00039
Domain-

UNC45A EFR3A VAC14 IPO9 ARVCF UTP20 RIPOR1 HECTD1 GCN1

1.48e-0422216391.25.10.10
DomainRNA-helicase_DEAD-box_CS

EIF4A3 DDX42 DDX27 EIF4A1

1.88e-04331634IPR000629
DomainARM-type_fold

USP34 UNC45A EFR3A VAC14 IPO9 ARVCF PIK3CD UTP20 RIPOR1 HECTD1 GCN1

1.98e-0433916311IPR016024
DomainQ_MOTIF

EIF4A3 DDX42 DDX27 EIF4A1

2.95e-04371634PS51195
DomainRNA_helicase_DEAD_Q_motif

EIF4A3 DDX42 DDX27 EIF4A1

2.95e-04371634IPR014014
DomainrSAM_horseshoe

RSAD1 CDK5RAP1

4.49e-0441632IPR023404
DomainPIN_4

SWT1 SMG5

4.49e-0441632PF13638
Domain-

RSAD1 CDK5RAP1

4.49e-04416323.80.30.20
Domain-

ACLY SUCLG2 SUCLA2

4.84e-041816333.30.470.20
DomainPkinase

RIPK1 KALRN CDK12 RIPK4 LRRK1 PRAG1 GSK3A GSK3B STK38L DCLK1 SBK3

5.32e-0438116311PF00069
DomainARM-like

UNC45A EFR3A VAC14 IPO9 ARVCF UTP20 RIPOR1 HECTD1 GCN1

6.23e-042701639IPR011989
DomainLaminin_domII

LAMA3 LAMA4

7.44e-0451632IPR010307
DomainLaminin_aI

LAMA3 LAMA4

7.44e-0451632IPR009254
DomainLaminin_I

LAMA3 LAMA4

7.44e-0451632PF06008
DomainLaminin_II

LAMA3 LAMA4

7.44e-0451632PF06009
DomainKinase-like_dom

EPHA6 RIPK1 KALRN CDK12 RIPK4 LRRK1 PRAG1 GSK3A GSK3B PIK3CD STK38L DCLK1 SBK3

9.60e-0454216313IPR011009
DomainPIN_dom

SWT1 SMG5

1.11e-0361632IPR002716
DomainPINc

SWT1 SMG5

1.11e-0361632SM00670
DomainSer/Thr_kinase_AS

RIPK1 KALRN CDK12 RIPK4 LRRK1 GSK3A GSK3B STK38L DCLK1 SBK3

1.19e-0335716310IPR008271
DomainProt_kinase_dom

EPHA6 RIPK1 KALRN CDK12 RIPK4 LRRK1 PRAG1 GSK3A GSK3B STK38L DCLK1 SBK3

1.24e-0348916312IPR000719
DomainS_TKc

RIPK1 KALRN CDK12 LRRK1 PRAG1 GSK3A GSK3B STK38L DCLK1 SBK3

1.24e-0335916310SM00220
DomainPROTEIN_KINASE_ST

RIPK1 KALRN CDK12 RIPK4 LRRK1 GSK3A GSK3B STK38L DCLK1 SBK3

1.32e-0336216310PS00108
DomainPROTEIN_KINASE_DOM

EPHA6 RIPK1 KALRN CDK12 RIPK4 LRRK1 PRAG1 GSK3A GSK3B STK38L DCLK1 SBK3

1.33e-0349316312PS50011
DomainElp3

RSAD1 CDK5RAP1

1.54e-0371632SM00729
DomainElp3/MiaB/NifB

RSAD1 CDK5RAP1

1.54e-0371632IPR006638
DomainLRR

NLRP12 LINGO2 LRRK1 NXF5 LRRC61 RXFP1 PHLPP2

1.95e-032011637PS51450
PathwayREACTOME_PI_METABOLISM

MTMR1 OCRL PIKFYVE VAC14 PIK3R6 PIK3CD PIK3R2 MTM1

2.63e-07771198MM14590
PathwayREACTOME_PI_METABOLISM

MTMR1 OCRL PIKFYVE VAC14 PIK3R6 PIK3CD PIK3R2 MTM1

5.19e-07841198M676
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE

MTMR1 OCRL PIK3R6 PIK3CD PIK3R2 MTM1

3.74e-06501196MM14641
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE

MTMR1 OCRL PIK3R6 PIK3CD PIK3R2 MTM1

5.29e-06531196M662
PathwayWP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY

MTMR1 OCRL PIKFYVE PIK3CD MTM1

4.10e-05461195M48317
PathwayWP_PHOSPHOINOSITIDES_METABOLISM

MTMR1 OCRL PIKFYVE PIK3CD MTM1

5.58e-05491195M40046
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE

PIKFYVE VAC14 MTM1

6.74e-05101193MM14644
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE

PIKFYVE VAC14 MTM1

9.21e-05111193M655
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE

PIKFYVE VAC14 MTM1

2.48e-04151193MM14643
PathwayREACTOME_PHOSPHOLIPID_METABOLISM

MTMR1 OCRL PIKFYVE VAC14 PIK3R6 PIK3CD PIK3R2 MTM1

2.54e-041961198MM14591
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE

PIKFYVE VAC14 MTM1

3.03e-04161193M639
PathwayREACTOME_LATE_SARS_COV_2_INFECTION_EVENTS

ANO1 GSK3A GSK3B GOLGA7 FURIN

3.08e-04701195M46438
PathwayREACTOME_PHOSPHOLIPID_METABOLISM

MTMR1 OCRL PIKFYVE VAC14 PIK3R6 PIK3CD PIK3R2 MTM1

4.18e-042111198M649
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE

OCRL PIKFYVE VAC14

4.36e-04181193M645
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE

OCRL PIKFYVE VAC14

4.36e-04181193MM14642
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

USP34 KDM5B KALRN CORO2A EIF4A3 KIF1B PFDN2 SMG5 RIPK4 DDX27 GSK3A YARS1 GMCL1 AP2M1 EIF4A1 MTM1 FBXO7 IFT122 KIFC3 GFPT2 CCDC24 FLOT1 NEUROD6 HECTD1 DCLK1

3.74e-0912851692535914814
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

DNAJB1 EPPK1 ACAT2 CORO2A CDK12 ACLY MATR3 DDX42 MTMR1 PFDN2 UNC45A TFG TUBA4A YARS1 PALS1 VAC14 AP2M1 IPO9 EIF4A1 ASCC3 STK38L GCN1

4.68e-0811491692235446349
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

CNNM2 PCDHA9 DYM MTMR1 PCDHA7 LINGO2 DCC EFR3A AP2M1 ARVCF RIPOR1 FLOT1 VCAM1

1.07e-074051691338187761
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

USP34 EPPK1 KALRN CDK12 SMG5 LRRK1 SRCAP PRAG1 RYR1 HIRA PIKFYVE VAC14 ARVCF PIK3CD PCNX4 FURIN RIPOR1 KIFC3 DNMBP HECTD1 GCN1

1.10e-0711051692135748872
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

EPPK1 EIF4A3 ACLY MATR3 DDX42 SRCAP TFG DICER1 DDX27 TUBA4A NCBP3 HOOK3 SMPDL3B EIF4A1 SYNE2 UTP20 ASCC3 FLOT1 GCN1 NUP160

1.46e-0710241692024711643
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

DNAJB1 APPBP2 CNNM2 DYM ATP7B RIPK1 SUCLA2 TFG DICER1 DDX27 AP2M1 GOLGA7 CDK5RAP2 UTP20 ASCC3 HECTD1 GCN1

1.85e-077541691733060197
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

EIF4A3 ACLY MATR3 KIF1B PFDN2 UNC45A DDX27 TUBA4A GSK3A GSK3B PALS1 AP2M1 IPO9 GSPT2 SMPDL3B ARVCF PIK3R2 EIF4A1 ASCC3 FLOT1 HECTD1 GCN1

1.92e-0712471692227684187
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

PDXDC1 EPPK1 ACAT2 ACLY MATR3 KIF1B PFDN2 LRRK1 UNC45A DDX27 GSK3A GSK3B YARS1 VAC14 IPO9 CDK2AP1 EIF4A1 DLG3 ACOT2 STK38L GCN1 NUP160

3.15e-0712841692217353931
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

GPR155 DNAJB1 KALRN ACLY ADGRV1 SUCLA2 RYR1 PALS1 AP2M1 SMPDL3B P2RX4 FAM151A GOLGA7 ABCB11 CDK5RAP2 RIPOR1 KIFC3 MYO15A FLOT1

5.89e-0710161691919056867
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

CORO2A DICER1 PIKFYVE SYNE2 DNMBP STK38L PHLPP2

7.08e-07102169710231032
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

ADAMTS19 RSAD1 CYP20A1 DDX42 CDH23 SMYD5 RIPK4 DDX27 GSK3A HIRA BPGM ARVCF COG6 PIK3R2 FBXO7 SLX4IP CDK5RAP2 DLG3 MYO15A CCDC24 DCLK1

7.40e-0712421692130973865
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

PDXDC1 DNAJB1 ACLY DNAH2 OCRL UNC45A NDUFA6 NR2F1 GSK3A GSK3B VAC14 LMF2 IPO9 EIF4A1 UTP20 ASCC3 HECTD1 GCN1

8.76e-079421691831073040
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

USP34 CDK12 EIF4A3 MATR3 SMG5 LRRK1 ADGRV1 NPEPL1 DICER1 EFR3A CASKIN2 CDK5RAP2 DNMBP

2.14e-065291691314621295
Pubmed

PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex.

GSK3A GSK3B NEUROD6

2.23e-066169327170189
Pubmed

Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.

SWT1 LINGO2 ADGRV1 DCC CDK5RAP2

2.38e-0644169520200978
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DNAJB1 UNC5B DDX42 MTMR1 UNC45A NDUFA6 SUCLA2 DICER1 DDX27 NCBP3 EFR3A CASKIN2 PIK3R2 SYNE2 CDK5RAP1 CDK5RAP2 COL14A1 LRRC61 IFT122 WDR41 ASCC3 FLOT1

3.51e-0614871692233957083
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

PDXDC1 EPPK1 EIF4A3 ACLY SMYD5 UNC45A NDUFA6 NPEPL1 TFG TUBA4A GSK3A GSK3B YARS1 AP2M1 LMF2 EIF4A1 SYNE2 FLOT1 HECTD1 NUP160

5.52e-0612971692033545068
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

PDXDC1 USP34 DNAJB1 CNNM2 ACLY MATR3 MTMR1 UNC45A DICER1 DDX27 DLGAP3 AP2M1 MTM1 ASCC3 HECTD1 GCN1 NUP160

5.96e-069741691728675297
Pubmed

Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.

ACLY SUCLG2 SUCLA2 GSK3A GSK3B BPGM

6.47e-0693169627215380
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

PDXDC1 ACAT2 CDK12 EIF4A3 ACLY CYP20A1 UNC45A SUCLG2 SUCLA2 TUBA4A GSK3A YARS1 IPO9 EIF4A1 FLOT1 GCN1

6.65e-068781691637223481
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

USP34 DNAJB1 DYM CORO2A UNC45A SUCLG2 SUCLA2 UBN2 DICER1 DDX27 HIRA NCBP3 AP2M1 IPO9 HOOK3 COG6 EIF4A1 SYNE2 ASCC3 FLOT1 GCN1

7.42e-0614401692130833792
Pubmed

MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling.

GSK3A GSK3B NEUROD6

9.27e-069169325224226
Pubmed

Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.

FOXM1 GSK3A GSK3B

9.27e-069169326912724
Pubmed

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

DNAJB1 EPHA6 EIF4A3 ACLY MATR3 SUCLG2 SUCLA2 TUBA4A AP2M1 EIF4A1 RIPOR1 FLOT1 GCN1 NUP160 DCLK1

9.78e-068031691536517590
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ACAT2 EIF4A3 ACLY MATR3 OCRL UNC45A SRCAP SUCLG2 DDX27 TUBA4A GSK3B HIRA AP2M1 IPO9 ARVCF EIF4A1 UTP20 ASCC3 GCN1 NUP160

1.02e-0513531692029467282
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

MBLAC2 DYM EPHA6 KIF1B FRMPD2 LAMA3 ADGRV1 SUCLA2 UBN2 PLEKHG4B SMPDL3B FAM120C PCNX4 NAXD CDK5RAP1 SLX4IP RIPOR1 IFT122 IGSF9B STK38L HECTD1

1.23e-0514891692128611215
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

DNAJB1 EIF4A3 MATR3 OCRL UNC45A SUCLG2 SUCLA2 YARS1 IPO9 HECTD1 GCN1 NUP160

1.30e-055341691235032548
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

USP18 CORO2A ADAM21 CDK12 EIF4A3 DNAH2 GSK3A GSK3B BPGM EIF4A1 FURIN MTM1 GFPT2 STK38L

1.46e-057301691434857952
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

USP34 CDK12 SMG5 ADGRV1 DICER1 SYNE2 STK38L GCN1

1.55e-05225169812168954
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

APPBP2 EPPK1 RIPK1 ACAT2 UNC5B KIF1B LAMA4 NPEPL1 DICER1 TUBA4A RYR1 NCBP3 SMPDL3B CDK2AP1 GOLGA7 FURIN NAXD WDR41 ABHD16A

1.88e-0512931691915342556
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP34 EPPK1 ACLY DDX42 DICER1 DDX27 EIF4A1 SYNE2 UTP20 ASCC3 HECTD1 GCN1 NUP160

2.03e-056531691322586326
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

FOXM1 EPPK1 NUP210L EIF4A3 DNAH2 UNC45A ZFP37 YARS1 SLC9A2 PCNX4 SYNE2 RIPOR1 TASOR NUP160

2.09e-057541691435906200
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

KALRN CORO2A ACLY MATR3 KIF1B HAPLN2 MTMR1 NDUFA6 SUCLA2 TUBA4A GSK3B YARS1 DLGAP3 AP2M1 ARVCF FAM120C DLG3 FLOT1 DNAH6 DCLK1

2.28e-0514311692037142655
Pubmed

Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3.

GSK3A GSK3B

2.35e-052169224523925
Pubmed

Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation.

GSK3A GSK3B

2.35e-052169216912034
Pubmed

Loss of glycogen synthase kinase 3 isoforms during murine oocyte growth induces offspring cardiac dysfunction.

GSK3A GSK3B

2.35e-052169225833158
Pubmed

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.

GSK3A GSK3B

2.35e-052169222065737
Pubmed

Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue.

GSK3A GSK3B

2.35e-052169216757548
Pubmed

Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development.

GSK3A GSK3B

2.35e-052169219064989
Pubmed

Mouse germ cell-less as an essential component for nuclear integrity.

GMCL1 GMCL2

2.35e-052169212556490
Pubmed

ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes.

PIKFYVE VAC14

2.35e-052169217475247
Pubmed

The role of glycogen synthase kinase 3 in the early stages of Alzheimers' disease.

GSK3A GSK3B

2.35e-052169218955053
Pubmed

Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response.

GSK3A GSK3B

2.35e-052169218500637
Pubmed

A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity.

PIKFYVE VAC14

2.35e-052169215542851
Pubmed

Glycogen synthase kinase-3β inhibits tubular regeneration in acute kidney injury by a FoxM1-dependent mechanism.

FOXM1 GSK3B

2.35e-052169232813289
Pubmed

Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells.

GSK3A GSK3B

2.35e-052169225833708
Pubmed

Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability.

GSK3A GSK3B

2.35e-052169227841351
Pubmed

Role of PKB/SGK-dependent phosphorylation of GSK-3α/β in vascular calcification during cholecalciferol overload in mice.

GSK3A GSK3B

2.35e-052169230119888
Pubmed

MicroRNA function is required for neurite outgrowth of mature neurons in the mouse postnatal cerebral cortex.

DICER1 NEUROD6

2.35e-052169224062642
Pubmed

Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

GSK3A GSK3B

2.35e-052169223606540
Pubmed

Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus.

GSK3A GSK3B

2.35e-052169225724980
Pubmed

Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3.

GSK3A GSK3B

2.35e-052169217548347
Pubmed

Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells.

GSK3A GSK3B

2.35e-052169219858210
Pubmed

Cyclic AMP and glycogen synthase kinase 3 form a regulatory loop in spermatozoa.

GSK3A GSK3B

2.35e-052169229574946
Pubmed

Glycogen synthase kinase 3: more than a namesake.

GSK3A GSK3B

2.35e-052169219366350
Pubmed

Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice.

GSK3A GSK3B

2.35e-052169221502951
Pubmed

Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances.

GSK3A GSK3B

2.35e-052169220357757
Pubmed

Differential regulation of STAT family members by glycogen synthase kinase-3.

GSK3A GSK3B

2.35e-052169218550525
Pubmed

Glycogen synthase kinase 3 in chronic rhinosinusitis: two faces of a single enzyme in one disease.

GSK3A GSK3B

2.35e-052169223352529
Pubmed

Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine.

GSK3A GSK3B

2.35e-052169227284979
Pubmed

Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication.

GSK3A GSK3B

2.35e-052169219106108
Pubmed

Glycogen synthase kinase-3 regulates inflammatory tolerance in astrocytes.

GSK3A GSK3B

2.35e-052169220553816
Pubmed

Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation.

GSK3A GSK3B

2.35e-052169225808536
Pubmed

Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity.

GSK3A GSK3B

2.35e-052169228630333
Pubmed

Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?

GSK3A GSK3B

2.35e-052169214550568
Pubmed

GSK3 inhibitor-BIO regulates proliferation of immortalized pancreatic mesenchymal stem cells (iPMSCs).

GSK3A GSK3B

2.35e-052169222384031
Pubmed

Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes.

GSK3A GSK3B

2.35e-05216929809441
Pubmed

Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload.

GSK3A GSK3B

2.35e-052169219106302
Pubmed

Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleus.

GSK3A GSK3B

2.35e-052169228244152
Pubmed

Cloning of the LamA3 gene encoding the alpha 3 chain of the adhesive ligand epiligrin. Expression in wound repair.

LAMA3 LAMA4

2.35e-05216928077230
Pubmed

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.

GSK3A GSK3B

2.35e-052169216176184
Pubmed

Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase 3.

GSK3A GSK3B

2.35e-052169222986169
Pubmed

Varicella-zoster virus requires a functional PI3K/Akt/GSK-3alpha/beta signaling cascade for efficient replication.

GSK3A GSK3B

2.35e-052169216934436
Pubmed

Myocardial stress remodelling after regional infarction is independent of glycogen synthase kinase-3 inactivation.

GSK3A GSK3B

2.35e-052169220696171
Pubmed

Identification of a novel human member of the DEAD box protein family.

DDX42 DICER1

2.35e-052169210727850
Pubmed

Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3.

GSK3A GSK3B

2.35e-052169220552232
Pubmed

GSK-3 parameters in lymphocytes of schizophrenic patients.

GSK3A GSK3B

2.35e-052169212379450
Pubmed

Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells.

GMCL1 GMCL2

2.35e-052169210448096
Pubmed

Pivotal roles of glycogen synthase-3 in hepatocellular carcinoma.

GSK3A GSK3B

2.35e-052169228619606
Pubmed

Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis.

GSK3A GSK3B

2.35e-052169231607568
Pubmed

Glycogen synthase kinase-3 overexpression replicates electroretinogram anomalies of offspring at high genetic risk for schizophrenia and bipolar disorder.

GSK3A GSK3B

2.35e-052169224138923
Pubmed

Elevated O-GlcNAcylation stabilizes FOXM1 by its reduced degradation through GSK-3β inactivation in a human gastric carcinoma cell line, MKN45 cells.

FOXM1 GSK3B

2.35e-052169229196265
Pubmed

GSK3β, but not GSK3α, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mammalian target of rapamycin complex1.

GSK3A GSK3B

2.35e-052169224397546
Pubmed

Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3.

GSK3A GSK3B

2.35e-052169225788881
Pubmed

PKB/SGK-dependent GSK3-phosphorylation in the regulation of LPS-induced Ca2+ increase in mouse dendritic cells.

GSK3A GSK3B

2.35e-052169223817039
Pubmed

AKT/SGK-sensitive phosphorylation of GSK3 in the regulation of L-selectin and perforin expression as well as activation induced cell death of T-lymphocytes.

GSK3A GSK3B

2.35e-052169222814108
Pubmed

GSK3β isoform-selective regulation of depression, memory and hippocampal cell proliferation.

GSK3A GSK3B

2.35e-052169226749572
Pubmed

Pathobiology and Therapeutic Relevance of GSK-3 in Chronic Hematological Malignancies.

GSK3A GSK3B

2.35e-052169235681507
Pubmed

An Association Study Between Genetic Polymorphisms in Functional Regions of Five Genes and the Risk of Schizophrenia.

DCC GSK3B

2.35e-052169227055860
Pubmed

Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations.

SUCLG2 SUCLA2

2.35e-052169227496549
Pubmed

Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart.

GSK3A GSK3B

2.35e-052169220299330
Pubmed

Dynamic range of GSK3α not GSK3β is essential for bidirectional synaptic plasticity at hippocampal CA3-CA1 synapses.

GSK3A GSK3B

2.35e-052169225208523
Pubmed

Promotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination.

GSK3A GSK3B

2.35e-052169227053198
Pubmed

C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells.

C1QTNF8 RXFP1

2.35e-052169224014093
Pubmed

Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain.

GSK3A GSK3B

2.35e-052169220831597
Pubmed

Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway.

GSK3A GSK3B

2.35e-052169229642012
Pubmed

Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression.

GSK3A GSK3B

2.35e-052169221325041
Pubmed

GSK3: A potential target and pending issues for treatment of Alzheimer's disease.

GSK3A GSK3B

2.35e-052169238946682
Pubmed

Loss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects.

FBXO7 NEUROD6

2.35e-052169237753846
Pubmed

Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells.

GSK3A GSK3B

2.35e-052169225561726
GeneFamilyDEAD-box helicases

EIF4A3 DDX42 DDX27 EIF4A1

1.01e-04421054499
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

KALRN UNC5B LINGO2 DCC IGSF9B VCAM1

3.54e-041611056593
GeneFamilyPhosphoinositide phosphatases

MTMR1 OCRL MTM1

8.35e-043210531079
GeneFamilyX-linked mental retardation|RNA helicases

DICER1 ASCC3

1.78e-031110521168
GeneFamilyLaminin subunits

LAMA3 LAMA4

2.12e-03121052626
GeneFamilyFibronectin type III domain containing

EPHA6 KALRN DCC COL14A1 IGSF9B

2.42e-031601055555
GeneFamilyMyotubularins|Phosphoinositide phosphatases

MTMR1 MTM1

3.34e-03151052903
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

WSB1 APPBP2 RSAD1 CDK12 MATR3 DDX42 MTMR1 OCRL DICER1 DDX27 NCBP3 EFR3A GSPT2 CDK2AP1 C7orf25 MTM1 SYNE2 CDK5RAP1 ASCC3 FLOT1 TASOR NUP160

1.22e-05121516922M41122
CoexpressionKIM_WT1_TARGETS_8HR_UP

WSB1 DNAJB1 MTMR1 DICER1 TUBA4A PIK3CD RIPOR1 GFPT2

1.34e-051671698M8857
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUP210L UNC5B ANO1 LAMA4 LINGO2 NR2F1 ELOVL3

4.50e-061721707073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA3 LAMA4 LINGO2 ADGRV1 DCC PRAG1 COL14A1

7.25e-06185170710da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN LINGO2 LRRK1 OTOGL NEUROD6 DNAH6 SEC14L5

8.05e-06188170750c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NUP210L ANO1 DQX1 FAM151A NXF5 CYP4F22 ITIH6

9.55e-061931707315840bc48899f3a36d57b19197509de19716e3d
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

USP34 KDM5B KIF1B ADGRV1 GSK3B EFR3A HECTD1

9.55e-061931707abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

WSB1 KALRN LAMA4 NR2F1 LURAP1L COL14A1 VCAM1

1.09e-05197170731a1852911bda38543916585fda34255fd62a134
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA3 LAMA4 NR2F1 FAM151A ABCB11 COL14A1 VCAM1

1.17e-0519917070cdbedf09ec72734b86ddab3fec562e066afed92
ToppCellNeuronal-Excitatory-eC(RORB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

FRMPD2 LAMA4 CCDC168 LRRK1 DCC OTOGL NEUROD6

1.20e-0520017078c803a0ce25e140b46036f6aabefc5502601f408
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP18 LURAP1L FAM151A ABCB11 DCLK1 VCAM1

3.14e-051571706c779a53b2c67d566f5d417e753cd17196a6bfd1c
ToppCelldroplet-Heart-nan-18m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXM1 CORO2A RYR1 BPGM RXFP1 DNAH6

3.74e-0516217067f425a3983325a5a3ea33f812b15aa010cc55de0
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 CASR PRAG1 COL14A1 HECTD1 DNAH6

3.74e-051621706373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDM5B ADGRV1 SMPDL3B DQX1 MTM1 LRRC61

4.01e-051641706b77995958c938e10a526118f75d78cee72e0b207
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_and_Lobular_Carcinoma-5|TCGA-Breast / Sample_Type by Project: Shred V9

GPR155 EPHA6 EIF4A3 RYR1 PIK3R2

4.29e-051011705f4db710b2510cdbee26dd5c3b581c85fe6f0be00
ToppCellControl-B_intermediate-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MATR3 PRAG1 PCNX4 NAXD PDXDC2P GCN1

4.43e-051671706948504367ecf58144d9dd74d2ec531358fc4b309
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD2 CCDC168 DCC OTOGL RXFP1 NEUROD6

4.58e-0516817061d58731a481ecac84c15affa84f8041dd67d944c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD2 CCDC168 DCC OTOGL RXFP1 NEUROD6

5.06e-0517117069d5cabd71a901a00eb16c4d151189296f1b3bf6f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD2 LRRK1 OTOGL RXFP1 NEUROD6 DNAH6

5.06e-0517117066a489a75eeab2a2d48d604682e93599c20a945fe
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PHACTR2 FRMPD2 LRRK1 RXFP1 NEUROD6 DNAH6

5.40e-0517317065aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CASR RIPK4 XKR7 SLC9A2 CCDC24 SEC14L5

5.57e-0517417063503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD2 CCDC168 DCC OTOGL RXFP1 NEUROD6

5.57e-051741706df5664da3b93c233509781429a9c6d7edf1b8944
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD2 LINGO2 CCDC168 LRRK1 DCC OTOGL

5.57e-051741706b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PHACTR2 LRRK1 OTOGL RXFP1 NEUROD6 DNAH6

5.57e-0517417062947e5906b172d149412fa4e77476fce4ea695d2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD2 CCDC168 DCC OTOGL RXFP1 NEUROD6

5.75e-051751706d4827b4dfad07f11cbdd47fbed287af1afb9b1b8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD2 CCDC168 LRRK1 DCC PRAG1 OTOGL

5.94e-05176170640993c41c1017b53039a337174fc56632b278609
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA4 LRRK1 DCC IGSF9B RXFP1 NEUROD6

6.32e-051781706731e1e8eff2c4018c75dfc66632a316010a09a9a
ToppCellRSV-Healthy-0|RSV / Virus stimulation, Condition and Cluster

PDXDC1 USP34 USP18 SYNE2 NUP160 ABHD16A

6.72e-051801706974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PHACTR2 EPHA6 LRRK1 COL14A1 RXFP1 DNAH6

6.72e-0518017068923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA3 LAMA4 LINGO2 DCC PRAG1 CDK2AP1

6.72e-0518017065391d23817f5cc88a0871ddb98968897c839f464
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-nan|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 ANO1 LAMA3 P2RX4 STK38L PHLPP2

6.72e-051801706a0faed4cf23f6d5e6e8f6b0284cea8a5bd0680a0
ToppCellRSV-Healthy-0|Healthy / Virus stimulation, Condition and Cluster

PDXDC1 USP34 USP18 SYNE2 NUP160 ABHD16A

6.72e-051801706703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA4 LINGO2 LRRK1 DCC RXFP1 NEUROD6

6.93e-0518117066e8c5460021d3999daec58e3d6661a6fa998fd16
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KALRN UNC5B LAMA3 CASKIN2 C7orf25 VCAM1

6.93e-051811706136b0c60680068838d184d32aa99d7bea8718dbc
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 CASR PRAG1 COL14A1 HECTD1 DNAH6

7.15e-051821706a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA4 LINGO2 LRRK1 DCC RXFP1 NEUROD6

7.37e-051831706274076a0978bce2bd53a1732045f18ef0f2d9985
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 RIPK4 PLEKHG4B SYNE2 KIFC3 DCLK1

7.59e-05184170642ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellBrain_organoid-organoid_Kanton_Nature|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.

ACAT2 DCC NR2F1 GSK3B NCBP3 SYNE2

7.82e-051851706857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN RXFP1 NEUROD6 DNAH6 DCLK1 SEC14L5

8.06e-05186170684ba666237c18189d7e7556bd92dd953af733c00
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 LAMA4 CASR PRAG1 LURAP1L COL14A1

8.30e-05187170687b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 YARS1 P2RX4 FURIN ASCC3 STK38L

8.30e-051871706ab109aa51beae3df474c15002e70361f328cadad
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 LAMA4 CASR PRAG1 LURAP1L COL14A1

8.30e-05187170642a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 LAMA4 CASR PRAG1 LURAP1L COL14A1

8.30e-05187170664afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WSB1 LAMA3 CASR LINGO2 COL14A1 HECTD1

8.30e-05187170677886f99c229610abd28c4c370d2c7d1536c9782
ToppCellfacs-Large_Intestine-Distal-18m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 YARS1 P2RX4 FURIN ASCC3 STK38L

8.30e-051871706a4c408fc941d2e8a811a26aa916c0b3e3341163a
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

CNNM2 KALRN ANO1 LAMA3 COL14A1 STK38L

8.54e-05188170634e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

CNNM2 KALRN ANO1 LAMA3 COL14A1 STK38L

8.80e-0518917066b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CORO2A LAMA3 RIPK4 ADGRV1 PLEKHG4B SMPDL3B

9.06e-051901706625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN LINGO2 RXFP1 DNAH6 DCLK1 SEC14L5

9.06e-05190170649e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS19 LAMA4 LURAP1L COL14A1 GFPT2 DCLK1

9.32e-0519117065271198116343c07202649889057e5774d7fdde3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KALRN UNC5B ANO1 LAMA4 NR2F1 DCLK1

9.32e-051911706107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KALRN UNC5B ANO1 LAMA4 NR2F1 DCLK1

9.32e-051911706bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS19 ANO1 LURAP1L COL14A1 GFPT2 DCLK1

9.59e-0519217064ed5040594ba2d0639f0990697504ecef872ca70
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS19 ANO1 LURAP1L COL14A1 GFPT2 DCLK1

9.59e-051921706d4f5d6653564c2c5d0f5f7c932d89cb1b1412844
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

CES1P1 PHACTR2 ANO1 LAMA4 NR2F1 KIFC3

9.59e-05192170662904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP18 LAMA3 NR2F1 ABCB11 DCLK1 VCAM1

9.87e-051931706c5bd0ed6f57459e54d2463318e8d9b1879718e63
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CORO2A LAMA3 RIPK4 ADGRV1 SMPDL3B CCDC24

1.02e-041941706413112ee8df7407fd418d57c2ff11aad3a6ec259
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRAT LAMA4 COL14A1 GFPT2 DCLK1 VCAM1

1.02e-041941706ca1f24070424b44b7a442e4fca761ebfbe24b063
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KALRN LAMA4 DCC NR2F1 LURAP1L COL14A1

1.02e-041941706a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP18 LAMA3 NR2F1 ABCB11 DCLK1 VCAM1

1.02e-041941706c45e9d09b5cd6973de6c3f1713b3bf36fa4bfe57
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MUC16 ADGRV1 OTOGL COL14A1 ITIH6 MYO15A

1.04e-041951706d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MUC16 ADGRV1 OTOGL COL14A1 ITIH6 MYO15A

1.04e-04195170619853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KALRN ANO1 LAMA4 COL14A1 RXFP1 DCLK1

1.07e-0419617061522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KALRN ANO1 LAMA4 COL14A1 RXFP1 DCLK1

1.07e-0419617061c8294014713684b50885e638668f2ce75f357f0
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 ANO1 LAMA3 RIPK4 TUBA4A DCLK1

1.10e-041971706f4dad4423384a2a25e064c849ffccf2811573be0
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KALRN ANO1 LAMA4 COL14A1 IGSF9B STK38L

1.10e-041971706bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

KALRN LAMA4 NR2F1 COL14A1 GFPT2 DCLK1

1.10e-041971706f1c8936986123a3151140c374fcd62d6705c530b
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP18 LAMA3 LURAP1L ABCB11 DCLK1 VCAM1

1.10e-0419717065fbbc570a4e77c703f569a4f85ce2d8af67d6297
ToppCellfacs-Diaphragm-Limb_Muscle-3m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WSB1 PHACTR2 RIPK1 MATR3 GSK3B EIF4A1

1.10e-041971706b0e2ea81308bce289cb7cbea0e27de1d01afeed2
ToppCellCOVID-19-lung-Fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

LAMA4 CDH23 NR2F1 LURAP1L COL14A1 GFPT2

1.14e-0419817063ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMA4 NR2F1 COL14A1 GFPT2 DCLK1 VCAM1

1.14e-041981706c66097ae9ba0b50561083c423565665958ef0bb8
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ACAT2 NR2F1 LURAP1L COL14A1 GFPT2 VCAM1

1.17e-04199170638ed3bc7daa993d9edcf3e7834597ebb06dd24f8
ToppCell356C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|356C / Donor, Lineage, Cell class and subclass (all cells)

LAMA4 NR2F1 COL14A1 GFPT2 DCLK1 VCAM1

1.17e-041991706675f7c56b03a7918e2d9ca99440df6f27ad8e838
ToppCellBronchial-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Mucous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ATP7B ANO1 MUC16 SLC22A17 OTOGL ITIH6

1.17e-041991706eb2d1b7e875c5bf833e7a80b43282e12893c34e9
ToppCell356C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|356C / Donor, Lineage, Cell class and subclass (all cells)

LAMA4 NR2F1 COL14A1 GFPT2 DCLK1 VCAM1

1.17e-04199170697d74985018816754d11a55b9fb689690ecb1374
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

FOXM1 ACLY CDH23 DCC SYNE2 NEUROD6

1.20e-0420017067c495030e6566b81d97b5516d1972e335ce5ed8c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ZMYND15 UNC5B DNAH2 CDH23 LRRK1 LURAP1L

1.20e-042001706aafe594c88710f8c53d59667cdac5035e08f5511
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

LAMA3 PALS1 DLGAP3 UBXN11 PCNX4 KIFC3

1.20e-042001706eac33be484dc443794e66e473f03e98406c2983e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ZMYND15 UNC5B DNAH2 CDH23 LRRK1 LURAP1L

1.20e-042001706a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMA4 NR2F1 COL14A1 GFPT2 DCLK1 VCAM1

1.20e-042001706d64895354218ebd0217011bae0967a6883bbd1cd
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Pax6|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PHACTR2 EPHA6 LINGO2 COL14A1 RXFP1

1.42e-04130170560e28d452d0e2af768459ba8dbe998117c94a251
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LRAT HAPLN2 FAM151A SEC14L5

1.49e-04701704b159435487b90331d2d276f182fc8aedf88d612c
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Il33_(Il33)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LRAT HAPLN2 FAM151A SEC14L5

1.49e-047017047e09547b73789d789c3c464689f7998445830238
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LRAT HAPLN2 FAM151A SEC14L5

1.49e-04701704b486f7fe68743e3385809cfd64512da2f31074df
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Il33_(Il33)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LRAT HAPLN2 FAM151A SEC14L5

1.49e-047017048ee9c9c78eec9dc0cec364ee7c9bc6f34d37de76
DrugZSTK474

GSK3A GSK3B PIKFYVE PIK3CD PIK3R2

1.19e-07171685CID011647372
Drug2-deoxy-D-glucose; Down 200; 10000uM; MCF7; HG-U133A

SRCAP GSK3A VAC14 LMF2 ARVCF CASKIN2 RIPOR1 LRRC61 STK38L NEUROD6

1.87e-0619416810344_DN
DrugPI-103

GSK3A GSK3B PIKFYVE PIK3CD PIK3R2

3.53e-06321685CID009884685
Diseaseheterogeneous nuclear ribonucleoprotein a/b measurement

NLRP12 GMCL2

1.87e-0441662EFO_0020441
Diseasestathmin-3 measurement

NLRP12 TUBA4A

3.11e-0451662EFO_0802088
Diseasegeneral transcription factor II-I measurement

NLRP12 PHACTR2

3.11e-0451662EFO_0801623
DiseaseCharcot-Marie-Tooth disease (implicated_via_orthology)

MTMR1 YARS1 MTM1

3.24e-04241663DOID:10595 (implicated_via_orthology)
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

EPPK1 GCNT4 CDK2AP1 ABCB11 ELOVL3 CDK5RAP2 DNMBP

4.27e-042391667EFO_0010934
Diseasestromal membrane-associated protein 1 measurement

NLRP12 UNC45A

4.65e-0461662EFO_0802094
Diseasefructose-1,6-bisphosphatase 1 measurement

NLRP12 PCNX4

4.65e-0461662EFO_0801606
DiseaseCholestasis of pregnancy

ABCB11 VCAM1

8.61e-0481662C0268318
Diseasesialic acid-binding Ig-like lectin 12 measurement

NLRP12 KALRN

8.61e-0481662EFO_0802066
Disease22q11 partial monosomy syndrome

HIRA ARVCF

1.10e-0391662C3266101
Diseasecentronuclear myopathy X-linked (implicated_via_orthology)

MTMR1 MTM1

1.10e-0391662DOID:0111225 (implicated_via_orthology)
Diseaseegg allergy measurement

ABCB11 ITIH6

1.10e-0391662EFO_0007018
DiseaseNonsyndromic Deafness

CDH23 ADGRV1 OTOGL MYO15A

1.15e-03811664C3711374
DiseaseAsymmetric crying face association

HIRA ARVCF

1.37e-03101662C0431406
Disease22q11 Deletion Syndrome

HIRA ARVCF

1.37e-03101662C2936346
Diseaselean body mass

PDXDC1 ANO1 LINGO2 ADGRV1 IPO9 SLX4IP TASOR NUP160

1.43e-033791668EFO_0004995
Diseaseanti-SARS-CoV-2 IgG measurement, response to COVID-19 vaccine

PHACTR2 SUCLG2

1.67e-03111662EFO_0803358, EFO_0803362
DiseaseLymphoma, Lymphocytic, Intermediate

GSK3B PIK3CD

1.67e-03111662C0751958
Diseasenucleus accumbens volume change measurement

MUC16 NEUROD6

1.67e-03111662EFO_0021493
Diseasealcohol consumption measurement

CDK12 CYP20A1 DNAH2 LINGO2 ADGRV1 DCC SUCLG2 DLGAP3 IPO9 ELOVL3 CDK5RAP2 IGSF9B MYO15A NUP160 DCLK1 PHLPP2

1.79e-03124216616EFO_0007878
Diseasemean platelet volume

KALRN CDK12 NUP210L KIF1B MTMR1 CASR SRCAP GMCL2 SYNE2 DLG3 RIPOR1 STK38L TASOR SEC14L5

1.94e-03102016614EFO_0004584
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

HOOK3 SYNE2

2.00e-03121662DOID:11726 (implicated_via_orthology)
Diseasefolic acid measurement

TUBA4A MYO15A NEUROD6

2.22e-03461663EFO_0005111
DiseaseAutosomal Dominant Myotubular Myopathy

RYR1 MTM1

2.36e-03131662C3661489
DiseaseCentronuclear myopathy

RYR1 MTM1

2.36e-03131662C0175709
DiseaseX-linked centronuclear myopathy

RYR1 MTM1

2.36e-03131662C0410203
DiseaseMyopathy, Centronuclear, 1

RYR1 MTM1

2.36e-03131662C4551952
DiseaseX-24588 measurement

ACOT2 DNMBP

2.36e-03131662EFO_0800898
DiseaseCongenital Structural Myopathy

RYR1 MTM1

2.36e-03131662C0752282
DiseaseMyopathy, Centronuclear, Autosomal Dominant

RYR1 MTM1

2.74e-03141662C1834558
DiseaseTubular Aggregate Myopathy

RYR1 MTM1

2.74e-03141662C0410207
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

FOXM1 NR2F1 PIK3CD ACOT2

2.97e-031051664DOID:9352 (implicated_via_orthology)
Diseaseattention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, schizophrenia, major depressive disorder

CNNM2 DCC FURIN

2.99e-03511663EFO_0003756, EFO_0003888, MONDO_0002009, MONDO_0004985, MONDO_0005090
DiseaseAutosomal Recessive Centronuclear Myopathy

RYR1 MTM1

3.15e-03151662C3645536
DiseaseDiGeorge Syndrome

HIRA ARVCF

3.58e-03161662C0012236
DiseaseCONOTRUNCAL ANOMALY FACE SYNDROME

HIRA ARVCF

3.58e-03161662C0795907
DiseaseMalignant lymphoma, lymphocytic, intermediate differentiation, diffuse

GSK3B PIK3CD

3.58e-03161662C0334634
DiseaseShprintzen syndrome

HIRA ARVCF

3.58e-03161662C0220704
Diseaseasthma

CDK12 MUC16 CASR PRAG1 PIKFYVE PLEKHG4B SLC9A2 COG6 FURIN CDK5RAP2 TASOR

3.62e-0375116611MONDO_0004979
Disease1-Methylhistidine measurement

CDK12 OTOGL

4.05e-03171662EFO_0021543
DiseaseC-X-C motif chemokine 16 measurement

ZMYND15 CDH23

4.54e-03181662EFO_0010911
DiseaseCongenital Fiber Type Disproportion

RYR1 MTM1

4.54e-03181662C0546264
Diseaseneuroticism measurement, cognitive function measurement

PCDHA9 KALRN NUP210L PCDHA7 DCC VAC14 FURIN IGSF9B ASCC3

4.91e-035661669EFO_0007660, EFO_0008354
Diseaseevent free survival time, urinary bladder cancer

DCC DCLK1

5.05e-03191662EFO_0000482, MONDO_0001187
Diseaseaspartate aminotransferase measurement

KALRN DNAH2 OCRL GCNT4 PRAG1 IPO9 ABCB11 WDR41 MYO15A DNMBP GCN1 NUP160

5.26e-0390416612EFO_0004736
Diseaseangina pectoris

PHACTR2 CNNM2 IPO9 FURIN

5.52e-031251664EFO_0003913
Diseaseunipolar depression, bipolar disorder, schizophrenia

ADAMTS19 NCBP3

5.59e-03201662EFO_0003761, MONDO_0004985, MONDO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
GFPITAIREIKILRQ

CDK12

766

Q9NYV4
IRATVRKERGLPVLV

ARVCF

701

O00192
RKERGLPVLVELLQS

ARVCF

706

O00192
EVVIPLKVISRGRSA

ADAM21

41

Q9UKJ8
EIIGPRDIIKIIEEI

ATP7B

611

P35670
LEPLIKEIVRRNITG

CASR

276

P41180
PVLLIRRTKDEIITT

ABHD16A

421

O95870
FKPGEREIVITLLAR

ADGRV1

831

Q8WXG9
REIVITLLARLDGIP

ADGRV1

836

Q8WXG9
RAIVRDPKILLLDEA

ABCB11

1231

O95342
VKRDVRTPLAVELEV

ACOT2

156

P49753
VEIVTIPSLKEGERL

DNMBP

56

Q6XZF7
ITAGLPVKVVVDVLR

APPBP2

236

Q92624
LGLKVLPVIKRTDRE

DICER1

1586

Q9UPY3
RVKIVINEIPDRVRG

CDH23

2956

Q9H251
LDGRTIPVVFKDVIR

DNAJB1

276

P25685
RVLVLVPTRELGIQV

DDX27

291

Q96GQ7
LRGIRIIPDVADLKI

EFR3A

496

Q14156
SRPDLLKVVRELLLG

CDK5RAP2

791

Q96SN8
RDDVLIKPSRVVAIL

GMCL1

171

Q96IK5
LLTDPIERGLRVIEI

GOLGA7

111

Q7Z5G4
ILDVPLGVISRVEKI

MTMR1

146

Q13613
PLGLVLRKLLDREET

PCDHA9

191

Q9Y5H5
DTPRIVLIRSRKVGL

P2RX4

16

Q99571
VRLVGKTPIETLIRD

NR2F1

391

P10589
EVLVIPAGARRIKVV

ADAMTS19

806

Q8TE59
DVKPLAEVGLRLVRL

CES1P1

261

Q9UKY3
PLGLVLRKLLDREET

PCDHA7

191

Q9UN72
LVKITDILRTRLEPV

MUC16

5076

Q8WXI7
LTVITREGKPRAVIV

DCC

951

P43146
EAISLIDLEVLRPKR

IFT122

1106

Q9HBG6
ILLQLKRRRTEEGPT

MATR3

141

P43243
GKSLVLVRVLVVPAE

LAMA3

1196

Q16787
SKVEPGELRETLILI

HAPLN2

71

Q9GZV7
RELLPGLKVIDGERV

LRRC61

151

Q9BV99
RGRVIAVLKARELTP

LRRK1

1941

Q38SD2
VLETVRIRKEGFPVR

MYO15A

1821

Q9UKN7
LKKRERVQIPVGIII

GPR155

471

Q7Z3F1
VRELVVGRIRNKPEV

KIF1B

1311

O60333
IVERLTKLIREVFPD

SMPDL3B

111

Q92485
PIRILVKRDELTLEG

EIF4A3

236

P38919
DFIRPKLVTIIRSGV

DCLK1

181

O15075
EKLARDILIDPIRVV

DDX42

446

Q86XP3
LKIRLKGIEEEEILP

GSPT2

491

Q8IYD1
AKVTGEVLDILTRLP

FLOT1

391

O75955
PIRILVKKEELTLEG

EIF4A1

231

P60842
VLAPRIESVETGLKL

MTG1

206

Q9BT17
GVLVERTVKEVLPAL

PFDN2

76

Q9UHV9
KIGIVRRILLTLVSP

PCNX4

441

Q63HM2
KLLRLDGRELSAPVI

NXF5

241

Q9H1B4
KELGIIPTIIRDEEL

NPEPL1

206

Q8NDH3
KDDIERGRLPLLLVA

PDXDC1

226

Q6P996
KDDIERGRLPLLLVA

PDXDC2P

226

Q6P474
PRVVDLLVIKGKIEL

NDUFA6

76

P56556
IDLRIPVPRVKLIDL

KALRN

2811

O60229
ELEIVPVRRSLKELI

NCBP3

46

Q53F19
GILEVSKARDIPVVI

NAXD

166

Q8IW45
RLILGVIVKVASIRV

LRAT

96

O95237
RRLIAIPEGIPIETK

LINGO2

46

Q7L985
DLVRKLGEKILPEII

GCN1

1951

Q92616
GRVPVLDTLIELVTR

KDM5B

1031

Q9UGL1
PLVREVGRTKLEVKV

AP2M1

291

Q96CW1
ELRRPVAVRAKDIGI

ANO1

771

Q5XXA6
SREELIRRGVLKELP

PHACTR2

71

O75167
ERIAPEVLRGKTILI

BPGM

171

P07738
AEIVTPEIREKLIRL

HOOK3

456

Q86VS8
IVLSILRIRSPEGRK

OR8J3

221

Q8NGG0
IVEVVSKRVGIPAAR

CASKIN2

341

Q8WXE0
LEKLPGDLRVVVVTD

DQX1

191

Q8TE96
IVRIEKARDIPLGAT

PALS1

256

Q8N3R9
PLLVKLVEAIERTGL

PIK3R2

126

O00459
EGVCRPLKVRIEQVI

COG6

351

Q9Y2V7
RIVDVRPTLVLVEKT

PIKFYVE

741

Q9Y2I7
IRLGLPVLLEELKET

DNAH6

3116

Q9C0G6
RKLIAVLESIERLPL

HECTD1

966

Q9ULT8
IIAGREPKETLREVL

TTC26

511

A0AVF1
EIIKVLGTPTREQIR

GSK3A

331

P49840
EIIRGLRSLPELIKE

GFPT2

506

O94808
PLEIGKSLEIRRRDI

GCNT4

81

Q9P109
ERVLEIIKQGVVALP

DYM

601

Q7RTS9
IELGDTAFIILRKRP

ELOVL3

126

Q9HB03
LLRQLTEEGKVRRPI

FAM151A

156

Q8WW52
GLVVLPLELKLRIFR

FBXO7

331

Q9Y3I1
PGERERATVLIKRIN

C7orf25

321

Q9BPX7
RRGIPKVIVVITDGR

COL14A1

1131

Q05707
IAEPGREIVRVTLKR

FRMPD2

766

Q68DX3
IIDILTEPKDIGKRL

FURIN

451

P09958
DRKIRVIDPRAGTVL

CORO2A

201

Q92828
LIIKTIPGREELRSL

DLGAP3

611

O95886
RRRLPVEVPSVILKE

FAM120C

681

Q9NX05
LVEIIKVLGTPTREQ

GSK3B

266

P49841
LLAIIEELGKEIRPT

CDK2AP1

66

O14519
EALKEAGPVVRLVVR

DLG3

201

Q92796
LPRVRPTIDIEILKG

C1QTNF8

56

P60827
LPDLRDIELKLGRKV

LURAP1L

6

Q8IV03
SRKRVLVVADVVVPG

MBLAC1

216

A4D2B0
IELVDRGLVEKVLPG

MBLAC2

216

Q68D91
RPGQLVKRLSIEVTV

ITIH6

166

Q6UXX5
RVRIAPKVLLAEEGI

FOXM1

416

Q08050
KIVIRELLPNGLRES

IPO9

106

Q96P70
VKIEGREGRILPKRI

CCDC168

4886

Q8NDH2
GKIDRFIIPRETLVL

CYP20A1

351

Q6UW02
LRKRELLKELLPVIG

HIRA

981

P54198
AQLLGIVVRKERPEL

DNAH2

3516

Q9P225
LRVDAPRLLRKIAGV

SEC14L5

61

O43304
QERGLPELLVKRVVA

SBK3

131

P0C264
ILRSLVPLEDLVGII

RYR1

2456

P21817
VPLRERREVKRILGE

CCDC24

16

Q8N4L8
VRRKPELILRTENGL

CYP4F22

506

Q6NT55
PLVAVERLRKVELGT

FADS6

181

Q8N9I5
RLARKVEVDSIVVPL

OTOGL

1616

Q3ZCN5
IGEIRVLGVDRVLRK

NUP210L

1711

Q5VU65
RLVKILEVLRELPVP

ARHGAP30

126

Q7Z6I6
RLVIDGLRVLEESLP

LAMA4

1566

Q16363
ILKLNTEIREVGPIE

EPHA6

166

Q9UF33
RKRVPLGRLELLEEV

RSAD1

341

Q9HA92
KRLGTVLPVIEKEID

UTP20

2401

O75691
ERKLLEVRGPFIIRQ

VAC14

541

Q08AM6
GRSRKEVELIIQVTP

VCAM1

586

P19320
EEVIPSRLDIRVGKI

YARS1

361

P54577
IRERPAAIPIEIKSI

STK38L

391

Q9Y2H1
IVIIPRTVIDGLDLL

SMG5

881

Q9UPR3
IILLKPEGDARIETI

SYNE2

2086

Q8WXH0
TKRKLLPEVLRDGEL

SLC22A17

496

Q8WUG5
VLRLLQGKEPVIRLV

LMF2

526

Q9BU23
VGEIAVLRIEGRKIP

SEC11B

66

P0C7V7
VLRIEGRKIPIVHRV

SEC11B

71

P0C7V7
IRVIARVRPVTKEDG

KIFC3

446

Q9BVG8
RDDVLIKPSRVVAIL

GMCL2

171

Q8NEA9
PVLVRILLRELEKAE

PIK3R6

51

Q5UE93
LGLPDLVAVLTRVIE

EPPK1

3216

P58107
VLRKLPGRLVTVVEE

SRCAP

2746

Q6ZRS2
PGRLVTVVEEKELVR

SRCAP

2751

Q6ZRS2
LSVEIDTLRRRPKIG

SWT1

76

Q5T5J6
PLSVKGRIILEIIEG

RIPK1

111

Q13546
VLRLLDVIGLPELVI

NUP160

966

Q12769
VRGVVELLLARKISV

RIPK4

531

P57078
KRPIREVPVTKLIDL

OCRL

691

Q01968
KIPVVVRLQGTRVDD

SUCLA2

401

Q9P2R7
VSLGSDRLVPREIIV

SLX4IP

311

Q5VYV7
LDREKLVLVKPLGDR

TASOR

451

Q9UK61
IIAEGIPEALTRKLI

ACLY

596

P53396
SRRLEPLGIIVKELT

ASCC3

551

Q8N3C0
RVLLKVEVPESGLRV

CYSLTR2

226

Q9NS75
NRRTSGIIEIEIKPL

CNNM2

166

Q9H8M5
PEEVKLRRLEELITI

CDK5RAP1

491

Q96SZ6
RELELKVPLVVRLEG

SUCLG2

381

Q96I99
GLPVLLEKRIEDLRV

UBN2

451

Q6ZU65
LRTEGPVIRIDLPRK

XKR7

516

Q5GH72
LILDVPLGVISRIEK

MTM1

81

Q13496
EIVPVLVSTRKGLIE

ACAT2

201

Q9BWD1
ILPLVGGKIEEVKRR

PHLPP2

196

Q6ZVD8
GITIRPLVEFLDVKR

SLC9A2

476

Q9UBY0
RILIDGTLIIFRVKP

IGSF9B

281

Q9UPX0
LIIKAQLGEDIRRIP

TFG

11

Q92734
IPRKEVRDLGLVVLV

PLEKHG4B

246

Q96PX9
LPVLRLVAREGDRVK

PIK3CD

96

O00329
VRPGKCRTITVLILI

RXFP1

521

Q9HBX9
PVALKEVLELERTLG

UNC5B

721

Q8IZJ1
LLLEADPIKRIRIGE

PRAG1

1306

Q86YV5
RILKRITVPRGADEQ

USP41

81

Q3LFD5
RILKRITVPRGADEQ

USP18

81

Q9UMW8
LEIIEALGKPNRRIR

USP34

1441

Q70CQ2
PRVNEKEIVRLRTIG

WSB1

6

Q9Y6I7
KEIVRLRTIGELLAP

WSB1

11

Q9Y6I7
ISVKAKIRRLEGIPI

ZFAND4

51

Q86XD8
LIRKGETIFVERPLV

SMYD5

41

Q6GMV2
VVLKALRLAPEGRLR

RIPOR1

1081

Q6ZS17
GVQILTKPETVDRRR

ZFP37

6

Q9Y6Q3
RELESLVPRLGVKLA

ZMYND15

276

Q9H091
GAIIVDPARELKVLI

UNC45A

281

Q9H3U1
VGKELIIFRLVAPTE

WDR41

191

Q9HAD4
LLATRVEVPLLGIVV

TMEM25

226

Q86YD3
GKEIIDPVLDRIRKL

TUBA4A

111

P68366
RLPKFVIRQGEVIDI

UBXN11

336

Q5T124
ELIRVPERLLFIIDG

NLRP12

281

P59046
LSEILRIGKRPDLLT

NEUROD6

146

Q96NK8