Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	G8	PKHD1L1 CEMIP	3.24e-05	4	44	2	PF10162
Domain	G8_domain	PKHD1L1 CEMIP	3.24e-05	4	44	2	IPR019316
Domain	G8	PKHD1L1 CEMIP	3.24e-05	4	44	2	PS51484
Domain	G8	PKHD1L1 CEMIP	3.24e-05	4	44	2	SM01225
Domain	WxxW_domain	MUC5B CEMIP	8.09e-05	6	44	2	IPR025155
Domain	Mucin2_WxxW	MUC5B CEMIP	8.09e-05	6	44	2	PF13330
Domain	Pectin_lyase_fold/virulence	PKHD1L1 CEMIP	1.51e-04	8	44	2	IPR011050
Domain	IQ	MYO3A CAMTA1 MYO5A	6.23e-04	71	44	3	PF00612
Domain	IQ	MYO3A CAMTA1 MYO5A	9.16e-04	81	44	3	SM00015
Domain	Cupredoxin	EFNA3 PKHD1L1	1.22e-03	22	44	2	IPR008972
Domain	IQ_motif_EF-hand-BS	MYO3A CAMTA1 MYO5A	1.24e-03	90	44	3	IPR000048
Domain	IQ	MYO3A CAMTA1 MYO5A	1.37e-03	93	44	3	PS50096
Domain	TIG	CAMTA1 PKHD1L1	2.42e-03	31	44	2	PF01833
Domain	IPT	CAMTA1 PKHD1L1	2.57e-03	32	44	2	IPR002909
Domain	Myosin_head_motor_dom	MYO3A MYO5A	3.61e-03	38	44	2	IPR001609
Domain	MYOSIN_MOTOR	MYO3A MYO5A	3.61e-03	38	44	2	PS51456
Domain	Myosin_head	MYO3A MYO5A	3.61e-03	38	44	2	PF00063
Domain	MYSc	MYO3A MYO5A	3.61e-03	38	44	2	SM00242
Domain	p53-like_TF_DNA-bd	NRK STAT2	6.93e-03	53	44	2	IPR008967
Pubmed	Aldosterone induces renal fibrosis by promoting HDAC1 expression, deacetylating H3K9 and inhibiting klotho transcription.	KL HDAC1	1.64e-06	2	45	2	30592280
Pubmed	Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1.	STAT2 HDAC1	1.64e-06	2	45	2	14645718
Pubmed	Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection.	IL2RA STAT2	1.64e-06	2	45	2	23986597
Pubmed	Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.	DCAF1 UBR2 STUB1	2.65e-06	21	45	3	22190037
Pubmed	Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome.	IFNGR1 IL2RA	4.91e-06	3	45	2	27085137
Pubmed	Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains.	NCOA2 HDAC1	4.91e-06	3	45	2	16649994
Pubmed	Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort.	IFNGR1 IL2RA	4.91e-06	3	45	2	16491350
Pubmed	Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells.	IFNGR1 KL	4.91e-06	3	45	2	37213666
Pubmed	Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells.	IL2RA HDAC1	4.91e-06	3	45	2	15713622
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	DCAF1 DHX33 DNAJC7 ATRX CEBPZ HDAC1	5.73e-06	349	45	6	25665578
Pubmed	STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.	IFNGR1 STAT2	9.81e-06	4	45	2	21379341
Pubmed	Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling.	IFNGR1 STUB1	9.81e-06	4	45	2	35395848
Pubmed	Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus.	IFNGR1 STAT2	9.81e-06	4	45	2	22496215
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	NCOA2 ZDBF2 LZTS2 STUB1 DNAJC7 ATRX STAT2	9.91e-06	588	45	7	38580884
Pubmed	A protein interaction landscape of breast cancer.	DCAF1 UBR2 MUC5B LZTS2 STUB1 DNAJC7 MYO5A	1.61e-05	634	45	7	34591612
Pubmed	High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.	IFNGR1 STAT2	1.63e-05	5	45	2	17846149
Pubmed	Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection.	IFNGR1 STAT2	1.63e-05	5	45	2	32094187
Pubmed	Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells.	NCOA2 HDAC1	1.63e-05	5	45	2	16645043
Pubmed	Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus.	STAT2 HDAC1	1.63e-05	5	45	2	25812002
Pubmed	Regulation of MHC Class I Expression in Lung Epithelial Cells during Inflammation.	IFNGR1 STAT2	2.45e-05	6	45	2	35173036
Pubmed	HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages.	DCAF1 HDAC1	2.45e-05	6	45	2	26679995
Pubmed	CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation.	RNF41 STUB1	3.42e-05	7	45	2	31754404
Pubmed	Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP.	STUB1 NRK	3.42e-05	7	45	2	32162334
Pubmed	Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail.	DCAF1 HDAC1	4.56e-05	8	45	2	22184063
Pubmed	Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.	APPL2 HDAC1	4.56e-05	8	45	2	19433865
Pubmed	APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.	APPL2 HDAC1	5.86e-05	9	45	2	15016378
Pubmed	HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.	DCAF1 HDAC1	5.86e-05	9	45	2	24116224
Pubmed	SATB1 targets chromatin remodelling to regulate genes over long distances.	IL2RA HDAC1	5.86e-05	9	45	2	12374985
Pubmed	BAL1/ARTD9 represses the anti-proliferative and pro-apoptotic IFNγ-STAT1-IRF1-p53 axis in diffuse large B-cell lymphoma.	IFNGR1 STAT2	5.86e-05	9	45	2	23487038
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	DCAF1 UBR2	5.86e-05	9	45	2	17855541
Pubmed	Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX.	ATRX HDAC1	5.86e-05	9	45	2	29084956
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	NCOA2 MASTL PIGW FAM216A CAMTA1 CUBN ATRX TUT7	6.71e-05	1084	45	8	11544199
Pubmed	14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.	DCAF1 UBR2 HDAC1	8.75e-05	66	45	3	23472066
Pubmed	Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation.	NCOA2 HDAC1	8.94e-05	11	45	2	16109736
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DCAF1 SCFD1 LZTS2 STUB1 DNAJC7 ATRX MYO5A CEBPZ C1orf43	1.03e-04	1487	45	9	33957083
Pubmed	Identification of novel oocyte and granulosa cell markers.	NCOA2 CAMTA1	1.27e-04	13	45	2	19539053
Pubmed	Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones.	STUB1 DNAJC7	1.27e-04	13	45	2	15189447
Pubmed	Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.	IFNGR1 IL2RA	1.47e-04	14	45	2	17152005
Pubmed	Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors.	STUB1 DNAJC7	1.70e-04	15	45	2	20661446
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	SCFD1 STUB1 TAMM41 MYO5A CEBPZ C1orf43 HDAC1	1.73e-04	925	45	7	28986522
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	MASTL MYO3A LZTS2 CUBN IL2RA	1.95e-04	415	45	5	16385451
Pubmed	Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.	ATRX HDAC1	2.20e-04	17	45	2	14519686
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	STUB1 ATRX MYO5A DAGLA	2.28e-04	231	45	4	16452087
Pubmed	Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.	ATRX HDAC1	2.47e-04	18	45	2	14645126
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	UBR2 STUB1	3.72e-04	22	45	2	24981174
Pubmed	CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.	DCAF1 STUB1 DNAJC7	3.76e-04	108	45	3	30166453
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	RNF41 LZTS2 SH3GLB1 APPL2 STUB1	3.91e-04	483	45	5	27107014
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	RNF41 SCFD1 STUB1 MYO5A CEBPZ TUT7	4.04e-04	754	45	6	33060197
Pubmed	High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density.	KL CALCR	4.07e-04	23	45	2	20654748
Pubmed	Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction.	STUB1 DNAJC7	4.82e-04	25	45	2	27483141
Pubmed	Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.	UBR2 APPL2 CEBPZ	4.87e-04	118	45	3	24453475
Pubmed	Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs.	CUBN IL2RA	5.63e-04	27	45	2	21510876
Pubmed	ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.	SCFD1 STUB1 DNAJC7 C1orf43	6.04e-04	299	45	4	37931956
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	RNF41 STUB1	6.06e-04	28	45	2	35474067
Pubmed	FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system.	FGF14 KL	6.50e-04	29	45	2	21876757
Pubmed	Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.	STUB1 DNAJC7	6.96e-04	30	45	2	25864199
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NCOA2 LZTS2 DNAJC7 CEBPZ HDAC1	6.98e-04	549	45	5	38280479
Pubmed	rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.	DHX33 SH3GLB1 MYO5A	8.34e-04	142	45	3	30217970
Pubmed	The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.	DCAF1 STUB1 DNAJC7 HDAC1	1.08e-03	350	45	4	26549023
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	RNF41 LZTS2 STUB1 DNAJC7 TAMM41	1.09e-03	606	45	5	36538041
Pubmed	Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.	ATRX STAT2	1.12e-03	38	45	2	28218735
Pubmed	A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.	RNF41 DHX33 STUB1 DNAJC7	1.24e-03	363	45	4	25036637
GeneFamily	SH2 domain containing	GRB14 STAT2	1.37e-02	101	32	2	741
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	STUB1 DNAJC7	1.76e-02	115	32	2	769
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	IFNGR1 IL2RA CLEC12A	3.19e-02	394	32	3	471
Disease	Hypercalcemia	KL CALCR	1.68e-04	13	44	2	C0020437
Disease	Milk-Alkali Syndrome	KL CALCR	1.68e-04	13	44	2	C0026141
Disease	Nystagmus	ATP10B FGF14	4.48e-04	21	44	2	HP_0000639
Disease	response to methotrexate, drug-induced liver injury	MYO3A FGF14	6.90e-04	26	44	2	EFO_0004228, GO_0031427
Disease	Hematopoetic Myelodysplasia	ATRX HDAC1	8.60e-04	29	44	2	C2713368

Protein segments in the cluster

Peptide	Gene	Start	Entry
AAVIQRCYRKYKQYA	CAMTA1	1551	Q9Y6Y1
AQYKCYDRMQQLPAY	CALCR	51	P30988
LYYSLQSANNVYLVM	MASTL	96	Q96GX5
NLNMTGYYRVNYDKL	LVRN	651	Q6Q4G3
YAQMYIQAYKTSNLR	CEMIP	1001	Q8WUJ3
RMVVYYLYKNVCYVN	ATP10B	1111	O94823
YMQNCPKSQRYAYVV	MUC5B	691	Q9HC84
CLYYLSYNQDAMERV	DCAF1	416	Q9Y4B6
IRYQKQLQHNYIQMY	LZTS2	611	Q9BRK4
YNLTQDMKYLYRACK	LANCL1	336	O43813
MAQTQGTRRKVCYYY	HDAC1	1	Q13547
IVTRLYCRQGYYLQM	FGF14	71	Q92915
VRIINCNVKYAYEYL	DNAH12	1206	Q6ZR08
YQRNTLQISYMVCQK	PATE3	56	B3GLJ2
YPKQYDNNMNCTYVI	CUBN	2936	O60494
AVRMTSIQCKLYQYY	ATRX	1836	P46100
TQGNQSCYNYLYRMK	C1orf43	91	Q9BWL3
SCYNYLYRMKALDAI	C1orf43	96	Q9BWL3
YVLYMVSRNGYRTCN	EFNA3	86	P52797
VYYTNRALCYLKMQQ	STUB1	61	Q9UNE7
VVYTELLYTNKCYMR	DHX33	666	Q9H6R0
YYCALNALQYRKQMA	APPL2	181	Q8NEU8
QMVYYQCVQGYRALH	IL2RA	146	P01589
TYIKAYLRRAQCYMD	DNAJC7	326	Q99615
KNSQEMLRYKEVCYY	DAGLA	281	Q9Y4D2
LRVYYMQNYINEALK	KL	886	Q9UEF7
AIRLLKYGMQLYQNY	GRB14	336	Q14449
KRYLCSIAKIYNANY	FAM216A	111	Q8WUB2
QMNRRYYENYVAKRI	RNF41	266	Q9H4P4
KAQYYAICFLNQMAL	CEBPZ	436	Q03701
TCYIRVYNVYVRMNG	IFNGR1	166	P15260
YMSYQAYIRILAKIQ	NRK	1366	Q7Z2Y5
CYYQEKVNLQERRKY	STAT2	676	P52630
TYYAQCYQYMLDLQK	SH3GLB1	236	Q9Y371
NLYMFSNCLIVYVLY	PIGW	481	Q7Z7B1
DLNNMYCGYINRLYV	CLEC12A	221	Q5QGZ9
YLRYNQEELMNKSVY	NCOA2	146	Q15596
CMAFQKAYYNLETRY	THAP9	631	Q9H5L6
MQKRQGYCSYCRVQY	ZDBF2	1	Q9HCK1
RMCQDLRNQLYESYY	SCFD1	101	Q8WVM8
SCSLYQYRLIYNMEK	PKHD1L1	541	Q86WI1
YYNSLIMCNGRLIKY	TAMM41	96	Q96BW9
YAYTLMVLYFLQQRN	TUT7	1171	Q5VYS8
NQIYYYHNVKCRREM	UBR2	676	Q8IWV8
MIQSYYQRYTEERNC	MYO3A	1236	Q8NEV4
MQRYVRGYQARCYAK	MYO5A	796	Q9Y4I1