Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 SIX4 ZNF658B ZNF496 ZNF454 ZNF501 PRDM14 ZNF181 ZIC2 ZNF697 ZNF646	9.54e-12	1459	65	24	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF34 ZNF536 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 SIX4 ZNF658B ZNF496 ZNF454 ZNF501 ZNF181 ZIC2 ZNF697 ZNF646	1.77e-10	1244	65	21	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF34 ZNF536 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 SIX4 ZNF658B ZNF496 ZNF454 ZNF501 ZNF181 ZIC2 ZNF697 ZNF646	2.63e-10	1271	65	21	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 SIX4 ZNF658B ZNF496 ZNF454 ZNF181 ZIC2 ZNF697 ZNF646	1.78e-09	1412	65	21	GO:0000981
Domain	-	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 ZNF285 ZNF496 ZNF454 ZNF501 PRDM14 ZNF181 ZIC2 ZNF697 ZNF646	1.30e-17	679	63	23	3.30.160.60
Domain	zf-C2H2	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 ZNF285 ZNF496 ZNF454 ZNF501 PRDM14 ZNF181 ZIC2 ZNF697 ZNF646	2.03e-17	693	63	23	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 ZNF285 ZNF496 ZNF454 ZNF501 PRDM14 ZNF181 ZIC2 ZNF697 ZNF646	2.09e-17	694	63	23	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 ZNF285 ZNF496 ZNF454 ZNF501 PRDM14 ZNF181 ZIC2 ZNF697 ZNF646	2.32e-16	775	63	23	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 ZNF285 ZNF496 ZNF454 ZNF501 PRDM14 ZNF181 ZIC2 ZNF697 ZNF646	2.45e-16	777	63	23	PS00028
Domain	Znf_C2H2-like	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 ZNF285 ZNF496 ZNF454 ZNF501 PRDM14 ZNF181 ZIC2 ZNF697 ZNF646	4.14e-16	796	63	23	IPR015880
Domain	Znf_C2H2	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 ZNF285 ZNF496 ZNF454 ZNF501 PRDM14 ZNF181 ZIC2 ZNF697 ZNF646	5.28e-16	805	63	23	IPR007087
Domain	ZnF_C2H2	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 ZNF285 ZNF496 ZNF454 ZNF501 PRDM14 ZNF181 ZIC2 ZNF697 ZNF646	5.72e-16	808	63	23	SM00355
Domain	KRAB	ZNF10 ZNF34 ZNF473 ZNF658 ZNF792 ZNF607 ZNF813 ZNF578 ZNF470 ZNF285 ZNF496 ZNF454 ZNF181	1.67e-10	358	63	13	PS50805
Domain	KRAB	ZNF10 ZNF34 ZNF473 ZNF658 ZNF792 ZNF607 ZNF813 ZNF578 ZNF470 ZNF285 ZNF496 ZNF454 ZNF181	1.67e-10	358	63	13	PF01352
Domain	KRAB	ZNF10 ZNF34 ZNF473 ZNF658 ZNF792 ZNF607 ZNF813 ZNF578 ZNF470 ZNF285 ZNF496 ZNF454 ZNF181	2.43e-10	369	63	13	SM00349
Domain	KRAB	ZNF10 ZNF34 ZNF473 ZNF658 ZNF792 ZNF607 ZNF813 ZNF578 ZNF470 ZNF285 ZNF496 ZNF454 ZNF181	2.51e-10	370	63	13	IPR001909
Domain	zf-C2H2_6	ZNF10 ZNF473 ZNF658 ZNF792 ZNF607 ZNF813 ZNF578 ZNF501 ZNF181 ZNF646	9.09e-08	314	63	10	PF13912
Domain	LCE	LCE1E LCE1A	1.47e-03	17	63	2	PF14672
Domain	LCE	LCE1E LCE1A	1.47e-03	17	63	2	IPR028205
Domain	SPRR/LCE	LCE1E LCE1A	4.00e-03	28	63	2	IPR026075
Domain	GDS_CDC24_CS	TIAM1 OBSCN	7.66e-03	39	63	2	IPR001331
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF142 ZNF143 ZNF473 RDH11 ZNF658 USP42 CLK1 ZNF813 UGT8 RAB11FIP5 ZNF581 CDC20 ZNF697 ZNF646	4.70e-08	1203	66	14	29180619
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF34 ZNF792 ZNF607 ZNF813 ZNF181 ZNF697	1.28e-06	181	66	6	37372979
Pubmed	Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.	OBSCN OBSL1	1.06e-05	3	66	2	20133654
Pubmed	Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.	OBSCN OBSL1	1.06e-05	3	66	2	31098411
Pubmed	Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.	OBSCN OBSL1	1.06e-05	3	66	2	27989621
Pubmed	Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.	OBSCN OBSL1	1.06e-05	3	66	2	20489725
Pubmed	The NIZP1 KRAB and C2HR domains cross-talk for transcriptional regulation.	ZNF10 ZNF496	2.12e-05	4	66	2	20176155
Pubmed	The molecular basis of the Caskin1 and Mint1 interaction with CASK.	TIAM1 APBA1	2.12e-05	4	66	2	21763699
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	RHOBTB2 CACNA1H CDC20	3.42e-05	33	66	3	19336002
Pubmed	RhoG signals in parallel with Rac1 and Cdc42.	TIAM1 PLD1	2.73e-04	13	66	2	12376551
Pubmed	Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.	ZNF10 ZNF34	3.18e-04	14	66	2	2014798
Pubmed	PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.	FLG PRDM14	3.18e-04	14	66	2	29178343
Pubmed	Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.	SLC39A4 FAM135A	3.67e-04	15	66	2	20970119
Pubmed	Rodent Lce gene clusters; new nomenclature, gene organization, and divergence of human and rodent genes.	LCE1E LCE1A	4.18e-04	16	66	2	17410201
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF142 ZNF143	4.74e-04	17	66	2	7557990
Pubmed	Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.	ZNF536 SFI1	5.32e-04	18	66	2	24939585
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF34 DMXL2 ZNF473 TIAM1 CLK1 APBA1 OBSL1 ABCC5 ZNF181	6.95e-04	1285	66	9	35914814
Pubmed	Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.	LCE1E LCE1A	7.99e-04	22	66	2	15854049
Pubmed	Differentially expressed late constituents of the epidermal cornified envelope.	LCE1E LCE1A	8.75e-04	23	66	2	11698679
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AOC1 ZNF473 CSNK1G3 OBSCN OGDHL PLD1 ZNF496 FAM135A	1.01e-03	1084	66	8	11544199
Pubmed	Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons.	RAB11FIP5 ZIC2	1.21e-03	27	66	2	33760820
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF536 RNF31 OBSL1 RAB11FIP5 PLD1 ANKRD52 ZIC2 ZNF646	1.21e-03	1116	66	8	31753913
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ZNF536 EXD3 ZNF142 ZNF143 RAB11FIP5 ANKRD52	1.33e-03	638	66	6	31182584
Pubmed	A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.	ZNF536 ZNF285	1.70e-03	32	66	2	23049088
Interaction	MDFI interactions	AANAT FBXL18 ZNF607 CSNK1G3 ZNF575 ZNF578 SFI1 ZNF581 LCE1A ZIC2 ZNF646	9.88e-08	430	64	11	int:MDFI
Interaction	KRTAP10-7 interactions	PCED1A ZNF792 CLK1 ZNF575 ZNF578 ZNF581 LCE1E LCE1A ZNF697	3.51e-07	293	64	9	int:KRTAP10-7
Interaction	KRTAP2-3 interactions	ZNF792 ZNF575 ZNF578 ZNF581 LCE1E LCE1A	5.63e-07	95	64	6	int:KRTAP2-3
Interaction	KRTAP2-4 interactions	ZNF792 ZNF575 ZNF578 ZNF581 LCE1E LCE1A	8.08e-07	101	64	6	int:KRTAP2-4
Interaction	KRTAP10-8 interactions	PCED1A ZNF473 ZNF792 ZNF575 ZNF578 ZNF581 LCE1E LCE1A ZNF697	4.68e-06	401	64	9	int:KRTAP10-8
Interaction	RNF4 interactions	ZNF142 ZNF143 ZNF473 RDH11 ZNF658 USP42 ZNF792 CLK1 ZNF813 UGT8 RAB11FIP5 ZNF581 CDC20 LCE1E ZNF697 ZNF646	6.07e-06	1412	64	16	int:RNF4
Interaction	CACNG5 interactions	ZNF142 CSNK1G3 OBSL1 PLD1	8.57e-06	41	64	4	int:CACNG5
Interaction	KRTAP10-9 interactions	ZNF473 ZNF792 ZNF578 ZNF581 LCE1E LCE1A ZNF697	1.11e-05	241	64	7	int:KRTAP10-9
Interaction	KRTAP10-5 interactions	ZNF34 ZNF792 ZNF578 LCE1E LCE1A ZNF697	1.17e-05	160	64	6	int:KRTAP10-5
Interaction	CARD10 interactions	ZNF10 ZNF575 ZNF581 ZNF285 PRDM14	5.20e-05	127	64	5	int:CARD10
Interaction	KRTAP10-10 interactions	ZNF473 CSNK1G3 LCE1E	8.46e-05	27	64	3	int:KRTAP10-10
Interaction	KRTAP9-2 interactions	RNF31 ZNF575 CDC20 LCE1E LCE1A	1.11e-04	149	64	5	int:KRTAP9-2
Interaction	KRTAP10-6 interactions	ZNF792 CLK1 LCE1E LCE1A	1.77e-04	88	64	4	int:KRTAP10-6
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF473 ZNF792 ZNF607 CPT1C ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 ZNF285 ZNF181	1.00e-06	1192	66	11	chr19q13
Cytoband	1q21.3	FLG LCE1E LCE1A	6.57e-04	117	66	3	1q21.3
Cytoband	19q13.11	ZNF792 ZNF181	1.94e-03	45	66	2	19q13.11
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF10 ZNF34 ZNF536 ZNF142 ZNF143 ZNF473 ZNF658 ZNF792 ZNF607 ZNF575 ZNF813 ZNF578 ZNF470 ZNF581 ZNF285 ZNF496 ZNF454 ZNF501 PRDM14 ZNF181 ZIC2 ZNF697 ZNF646	2.91e-19	718	51	23	28
GeneFamily	Late cornified envelope proteins	LCE1E LCE1A	1.16e-03	18	51	2	627
Coexpression	ZWANG_DOWN_BY_2ND_EGF_PULSE	ZNF658 ZNF792 STC2 ZNF470 ZNF454 ZNF181 ZNF646	1.47e-05	321	65	7	M2615
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AANAT ZNF536 ZNF792 NSMAF ZNF646	4.94e-06	167	66	5	b742558ca92985db0a67c88f530bc375f3d3bb98
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-4\|TCGA-Liver / Sample_Type by Project: Shred V9	ZNF792 SOBP ZNF813 SFI1 ZNF496	5.23e-06	169	66	5	0a3ba6b5d6cff9d3d7f56046063cfc3a37ae1156
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 FBXL18 CPT1C ZNF454 ZNF646	7.91e-06	184	66	5	a6dee97ee4ef9d89e11d17339e0dadaea1210ce5
Disease	Peripheral Nervous System Diseases	CPT1C RHOBTB2 CACNA1H	2.13e-04	54	63	3	C4721453
Disease	cognitive function measurement	TNNI3K DMXL2 ZNF536 EXD3 APBA1 UGT8 RAB11FIP5 ABCC5 CACNA1H PRDM14	8.66e-04	1434	63	10	EFO_0008354
Disease	pathological myopia	ZNF536 SOBP ZNF285	1.75e-03	111	63	3	EFO_0004207
Disease	cytotoxicity measurement, response to clozapine	HMCN1 NSMAF	1.76e-03	29	63	2	EFO_0006952, GO_0097338
Disease	renal cell carcinoma	RHOBTB2 PLD1	3.66e-03	42	63	2	EFO_0000681

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSGHIHHHDVRVAEH	CDC20	286	Q12834
HRLALGSRRAHHHHG	ANTXRL	41	A6NF34
RHISHHANALCHFHI	DMXL2	346	Q8TDJ6
HCHTNRGLAAHRHLF	CFAP161	221	Q6P656
SRHHEASSHADISRH	FLG	911	P20930
RHGTRLHTHLIGNIH	AOC1	496	P19801
RSALHHAVHSGHLET	ANKRD52	141	Q8NB46
KHRIHHSTSHRRSHG	CLK1	116	P49759
HHHHQGLSRSELGRR	RAB11FIP5	466	Q9BXF6
HIHSDGHRHRLVLNG	OBSL1	1586	O75147
RGHLFHVSRVLGQHH	MFSD4A	181	Q8N468
CGHASHSLARLLLRH	ASB18	301	Q6ZVZ8
RTLKLHFSPHRGLHH	FAM135A	136	Q9P2D6
ERGTFSHRHHVLHDQ	OGDHL	666	Q9ULD0
QHAHRHLSHLLLTHV	PCED1A	251	Q9H1Q7
NPHHLRAHLAADRHG	CSNK1G3	376	Q9Y6M4
NAAGSAHRHVTLHVH	HMCN1	3971	Q96RW7
GSHHALLLRSAQPHH	OBSCN	4486	Q5VST9
HIHLGHLRLQRTLHS	ABCC5	566	O15440
HLHDSQHVAVFHRGR	CPT1C	326	Q8TCG5
IIRHNGAHHLRAAVH	UGT8	451	Q16880
THRRALPNHLHFHSL	APBA1	141	Q02410
HRANHILHKGSHHER	NSMAF	36	Q92636
GCCLSHHRRHRSHRH	LCE1A	66	Q5T7P2
HHRRHRSHRHRLQSS	LCE1A	71	Q5T7P2
CLSHHRHHRSHRHRP	LCE1E	76	Q5T753
GHSDVRLSAHHHRMR	C2orf81	321	A6NN90
RAGRHTASVHHLVYH	CACNA1H	506	O95180
RADLHHQHSVLHRAL	SFI1	641	A8K8P3
SSLAHHLGRIHFHNL	RDH11	176	Q8TC12
LHRSGGHIAHLHVLA	AANAT	111	Q16613
GHIAHLHVLAVHRAF	AANAT	116	Q16613
FASHAAHDSHVRRSH	PRDM14	526	Q9GZV8
LHRHHLHDADSISSI	PLD1	566	Q13393
RHLNLSAAHHHSSEG	FBXL18	386	Q96ME1
SAAHHHSSEGLGRHL	FBXL18	391	Q96ME1
HHHHGRDFLLRAASF	RHOBTB2	331	Q9BYZ6
LGVGREAHSDHSHRH	SLC39A4	231	Q6P5W5
LHSELLGRHHHAAAA	SIX4	86	Q9UIU6
DHLFHGHPSRAHHLR	RNF31	241	Q96EP0
RCSHHHSRHRSGVEL	USP42	1016	Q9H9J4
AHHLKVHERSHTGDR	ZNF143	251	P52747
QSHLSRHHRLHTGEK	ZNF578	411	Q96N58
FIHQSSLARHHRLHT	ZNF578	436	Q96N58
NVQSHLSRHHRLHTG	ZNF578	521	Q96N58
AIHSACATAVARHHH	TIAM1	541	Q13009
RARLHNVIHRALHAH	SOBP	661	A7XYQ1
RTKLSRAHHGEAGHH	STC2	231	O76061
KLAAHRHTHHATDAR	ZNF575	161	Q86XF7
SQRAHLAHHNRIHTG	ZNF607	431	Q96SK3
HRGSLVNHRHSHRTG	ZNF646	476	O15015
RQSTHLAHHQRIHTG	ZNF470	491	Q6ECI4
STLRSHRGHHCPHLH	nan	16	Q5BKY6
NQKAHLARHHRLHTG	ZNF813	561	Q6ZN06
FAHNSALRAHHRIHT	ZNF658	611	Q5TYW1
HLLSHRRAHAAASGA	ZNF697	331	Q5TEC3
RTSHHLKVHLRIHTG	ZNF536	761	O15090
QRSHLVVHHRIHTGL	ZNF10	416	P21506
FQRHDHLARHRSHFH	ZNF496	531	Q96IT1
LIHHKRVHTGRSAHE	ZNF792	381	Q3KQV3
FIRNIHLAHHHRIHT	ZNF454	281	Q8N9F8
AGLRHHALTHTDRHP	ZNF142	1606	P52746
RASHLARHHSIHLAG	ZNF581	126	Q9P0T4
HTGLHSACYHGHIRL	TNNI3K	341	Q59H18
RRSSSLHNHHRVHTG	ZNF285	326	Q96NJ3
RHSSALLRHQRLHAG	ZNF501	256	Q96CX3
SHRSSLLQHHRIHTG	ZNF181	471	Q2M3W8
NSSRLIHHQRLHHGE	ZNF34	486	Q8IZ26
SFARHHHHSAAAAAA	ZIC2	16	O95409
HRHTHLNEHRRIHTG	ZNF473	441	Q8WTR7
FAHNSALRAHHRIHT	ZNF658B	371	Q4V348
RSCLLAHVHRLHHEG	EXD3	136	Q8N9H8
AHVHRLHHEGRFREA	EXD3	141	Q8N9H8