Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsingle-stranded DNA 3'-5' DNA exonuclease activity

POLE POLG

1.91e-046722GO:0008310
GeneOntologyMolecularFunctionDNA polymerase activity

POLE POLG TERT

3.46e-0438723GO:0034061
GeneOntologyMolecularFunctionsingle-stranded DNA exodeoxyribonuclease activity

POLE POLG

5.66e-0410722GO:0008297
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

JAG2 CCDC71L PWWP2B WIZ GTPBP6 POLE TMEM158 POLG ZBTB4 CHSY1 CEP170B PCNT

4.12e-061105751235748872
Pubmed

[Correlation of hTERT expression to maspin and bFGF expression and their significance in glioma].

FGF2 TERT

4.59e-06275217562265
Pubmed

Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation.

TPRX1 TPRX2

1.37e-05375236074823
Pubmed

Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor.

FGF2 TERT

1.37e-05375220628269
Pubmed

Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.

TERT PRRC2A

1.37e-05375223221128
Pubmed

Cav2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization.

CACNA1A ICAM5

2.75e-05475222279216
Pubmed

Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos.

TPRX1 TPRX2

2.75e-05475227412763
Pubmed

A draft map of the human proteome.

PERM1 EZHIP

4.57e-05575224870542
Pubmed

A germline-specific class of small RNAs binds mammalian Piwi proteins.

BTBD6 ABL2 FKRP POLG ZBTB4 PRRC2A SLC66A1

5.39e-0545075716751776
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

CACNA1A ABL2 CDC42EP4 CBARP PRRC2A CEP170B

1.07e-0434775617114649
Pubmed

Tumor angiogenesis and endothelial cell modulatory factors.

ICAM5 FGF2

1.64e-04975210335479
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

JAG2 FAM171A2 EARS2 FKRP POLE LEMD2 CHSY1 KIRREL1 MINDY1

1.92e-0494275931073040
Pubmed

Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.

BHLHA15 MESP2

2.99e-041275214516699
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ABL2 CDC42EP4 FAM171A2 MTMR1 KIRREL1 CBARP

3.02e-0442175636976175
Pubmed

Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization.

PRR36 CEP170B

4.11e-041475234674267
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

WIZ FAM171A2 PPP2R3B MTMR1 KIRREL1 CBARP FBXO33 PRRC2A PCNT

4.21e-04104975927880917
Pubmed

Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.

WIZ POLG CHSY1 PRRC2A CEP170B

6.61e-0432175532098917
Pubmed

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

POLG PRRC2A

7.66e-041975222267201
Pubmed

ATRX proximal protein associations boast roles beyond histone deposition.

CCDC71L WIZ ZBTB4

1.02e-039175334780483
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CACNA1A WIZ FAM171A2 PRR36 ICAM5 PRRC2A CEP170B PCNT

1.10e-0396375828671696
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

WIZ POLE MTMR1 PRRC2A

1.62e-0323275425515538
Pubmed

EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades.

JAG2 FGF2

1.79e-032975224909139
Pubmed

Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.

JAG2 FGF2

1.79e-032975224971735
Cytoband17q24-q25

CDC42EP4 FDXR

1.58e-05475217q24-q25
CytobandXp22.33

GTPBP6 PPP2R3B

7.71e-0425752Xp22.33
GeneFamilyDNA polymerases

POLE POLG

1.29e-0323422535
GeneFamilyBeta 3-glycosyltransferases

B3GNT9 CHSY1

1.41e-0324422426
GeneFamilyPseudoautosomal region 1|Solute carriers

GTPBP6 PPP2R3B

1.53e-0325422715
GeneFamilyBasic leucine zipper proteins|BTB domain containing

BTBD6 KBTBD6 ZBTB4

3.70e-03134423861
DrugNSC 249232

POLG FDXR TMEM70

2.00e-0517723CID000099884
Drugpoly(vA

POLE POLG TERT

2.83e-0519723CID000429118
Drugdercitin

POLE POLG TERT

2.83e-0519723CID000130774
Drugaucubigenin

POLE POLG TERT

2.83e-0519723CID000163040
Drug5-ClAU

POLE POLG TERT

2.83e-0519723CID000126441
DrugOXT-ATP

POLE POLG TERT

3.33e-0520723CID000454146
DrugAC1MHT6K

POLE POLG TERT

3.33e-0520723CID003010960
DrugAC1L3V16

POLE POLG TERT

3.87e-0521723CID000122664
Drugparazoanthoxanthin A

POLE POLG TERT

3.87e-0521723CID000323259
Drugchlorpromazine hydrochloride; Down 200; 1uM; MCF7; HT_HG-U133A

CDC42EP4 WIZ POLG FDXR TUSC2 MINDY1

4.00e-051997266977_DN
Drugpetasiphenol

POLE POLG TERT

4.47e-0522723CID006438779
DrugBVdUTP

POLE POLG TERT

4.47e-0522723CID006438404
DrugU-78036

POLE POLG TERT

4.47e-0522723CID000072244
DrugAC1LA211

POLE POLG TERT

4.47e-0522723CID000480107
DrugBrVarafUTP

POLE POLG TERT

5.85e-0524723CID005273539
DrugAC1L1CVV

POLE POLG TERT

7.48e-0526723CID000027281
DrugaraTTP

POLE POLG TERT

8.40e-0527723CID000072188
DrugR)-PCV-TP

POLE POLG TERT

9.39e-0528723CID000506602
DrugAC1LAIP3

POLE POLG TERT

1.04e-0429723CID000469173
DrugUC-3

POLE POLG TERT

1.04e-0429723CID003000477
Diseaseurinary bladder cancer (is_implicated_in)

FGF2 TNFRSF10A TERT

8.62e-0476723DOID:11054 (is_implicated_in)
Diseaselung squamous cell carcinoma (is_implicated_in)

POLE TERT

1.57e-0324722DOID:3907 (is_implicated_in)
DiseaseSeizures

FKRP POLG TMEM70 FGF2

2.01e-03218724C0036572

Protein segments in the cluster

PeptideGeneStartEntry
AGAARPARAPLRRGD

CBARP

606

Q8N350
SRVQAGPGSPRRARG

CCDC137

11

Q6PK04
AVARPGRAATSGPRR

CACNA1A

2326

O00555
RRGRAAPAARDSLPV

ARSD

6

P51689
RPAPTDGPRSRVAGR

CERS4

371

Q9HA82
SAARPSGRRRDPAGR

ABL2

26

P42684
LPRPRRGARARGAAS

BTBD6

26

Q96KE9
PSPDGRRAAGVRLAV

FDXR

316

P22570
LRRRARPDSAPGGRT

ASB10

136

Q8WXI3
LRSRPARAAARAPGE

BHLHA15

41

Q7RTS1
ARVAPRAATHARGRG

C8orf34

26

Q49A92
HDRPTRGAAAGARRP

BAG1

56

Q99933
PARPFGSVGRRSRLA

CEP170B

486

Q9Y4F5
RAGVRARRAAPVRTP

ADAMTS2

81

O95450
ARRAAPVRTPSFPGG

ADAMTS2

86

O95450
RRPPRAAGGATAGSR

MTMR1

26

Q13613
HAPRRPLVRTGVAGA

RGS9BP

106

Q6ZS82
PRNAPHVRGTRRSAG

PPP2R3B

91

Q9Y5P8
ALRPRAPAARGGVSR

MCUR1

51

Q96AQ8
RVGRGRSAPRAAAPS

GTPBP6

16

O43824
RATRAGPAGAARARP

LEMD2

186

Q8NC56
KAAPGRRPRRGSTAA

KCNK16

276

Q96T55
AAGPVAAPREAFRGR

SLC66A1

151

Q6ZP29
PPAGAAGDRARARAR

JAG2

106

Q9Y219
PRRARTGPAGGQRQS

MESP2

71

Q0VG99
RGRDSAPVSAPRGRD

EZHIP

291

Q86X51
ARRGRDSAPGPALRV

EZHIP

311

Q86X51
RPPGARTRAGAARVA

FBXO33

11

Q7Z6M2
PRRFRRSVPRGEAAG

PCSK1N

56

Q9UHG2
RRSFAGEPPRARGAV

ICAM5

166

Q9UMF0
SARRRGPPRASAAGL

INSIG1

16

O15503
GATSGRPAGERRQRP

MINDY1

446

Q8N5J2
RRSAPGSTPVRRRGA

POLE

2016

Q07864
RDPARGRRLAAAASP

PCNT

3261

O95613
VAAPEGRAATVPRGR

FAM171A2

756

A8MVW0
ARARAGSVRPRGQPT

RBBP8NL

366

Q8NC74
ARRLRARPGRPSGDS

DSCR9

11

P59020
ARPSRPGGPQSRARV

FNDC1

1136

Q4ZHG4
GLARRPPARRAVDVG

CENPT

206

Q96BT3
RSPAFRGPDRARAAV

CDC42EP4

321

Q9H3Q1
RGPDRARAAVSRQPD

CDC42EP4

326

Q9H3Q1
GRGTAAPRAAPAARG

FGF2

111

P09038
RAPGPARFDGRPSSR

KIRREL1

626

Q96J84
TARGQARRPVPRAAA

CCDC71L

116

Q8N9Z2
ARGPRRASAAGPRVT

FKRP

36

Q9H9S5
AAPRARRRLGSGPDR

PWWP2B

196

Q6NUJ5
PDVGAQRSRRRGSPE

PERM1

621

Q5SV97
DAPRSRRLASPRGGK

KBTBD6

6

Q86V97
GRGAPQRRAPAEARA

POLG

116

A0A3B3IS91
VVVAGRPSCSRGPRR

SCHIP1

166

P0DPB3
HAPSRGRRARSAPAG

PPP1R3E

56

Q9H7J1
GGGARAPRSRSPDTR

PPP1R3E

71

Q9H7J1
RRPSAGGGLQRPASR

PRR36

226

Q9H6K5
AVPRARAARRAAGSG

GDF7

66

Q7Z4P5
PSPAPARFTARGGRV

PRRC2A

1146

P48634
ERRQARPPDASAARG

WIZ

1536

O95785
AAGSRGRRAPRPREQ

TRPT1

11

Q86TN4
RERPSAASGRPVGRR

EARS2

11

Q5JPH6
ASAPRGRGRAAPRPT

B3GNT9

36

Q6UX72
RAGPRRRASPEGCRS

CHSY1

36

Q86X52
AVEAPGRGARRPTRQ

LINC00612

121

Q8N6U2
GERLGARRNSAPRAP

C11orf96

231

Q7Z7L8
DAPSRPGRLAGRVQA

SLC49A3

526

Q6UXD7
LRRRQTALRAGAGPP

RINL

376

Q6ZS11
LPARGRPRSRNGLAS

ZFP28

41

Q8NHY6
QRGRGARAAPLVPAA

TPRX1

36

Q8N7U7
GRRTGRLRPAAAPSA

TMEM158

151

Q8WZ71
RGRAVPPFVFTRRGS

TUSC2

36

O75896
PAAESPAGRARTERR

ZBTB4

711

Q9P1Z0
RGLAPRGRSAAAAGP

TMEM275

86

A0A0U1RQS6
ARARAGRAPGPRPAR

TNFRSF10A

66

O00220
QGARRAQAAPAVGPR

NSMCE3

66

Q96MG7
LRASRPAALGGPARA

ZNF853

631

P0CG23
PRAALGPVVGARRGR

ZNF213

286

O14771
PSGAARLLRRPGRAQ

TMEM70

56

Q9BUB7
PRAGPSRAQGRREAA

TTC34

6

A8MYJ7
LPAPGARRRGGSASR

TERT

216

O14746
QRGRGARAAPLVPVA

TPRX2

91

P0DV77
AVASARGRRLPPAGS

ZFTA

21

C9JLR9
ARASRPGKSRIPGRD

ZFTA

86

C9JLR9