Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC25A3 CACNA1B CACNA1C SLC17A5 GABRP SLC7A1 SLC7A2 SLC7A4 SLC35A3 ATP6V0B SLC7A3 SLC16A9 HNRNPA3 OCA2 SLC38A11 SLC7A14 KCNT1 ABCA9 SLC9A6	2.71e-07	1180	83	19	GO:0022857
GeneOntologyMolecularFunction	L-ornithine transmembrane transporter activity	SLC7A1 SLC7A2 SLC7A3	6.88e-07	5	83	3	GO:0000064
GeneOntologyMolecularFunction	transporter activity	SLC25A3 CACNA1B CACNA1C SLC17A5 GABRP SLC7A1 SLC7A2 SLC7A4 SLC35A3 ATP6V0B SLC7A3 SLC16A9 HNRNPA3 OCA2 SLC38A11 SLC7A14 KCNT1 ABCA9 SLC9A6	1.04e-06	1289	83	19	GO:0005215
GeneOntologyMolecularFunction	basic amino acid transmembrane transporter activity	SLC7A1 SLC7A2 SLC7A4 SLC7A3	1.28e-06	20	83	4	GO:0015174
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC7A1 SLC7A2 SLC7A4 SLC7A3 SLC38A11 SLC7A14	4.98e-06	105	83	6	GO:0015171
GeneOntologyMolecularFunction	L-lysine transmembrane transporter activity	SLC7A1 SLC7A2 SLC7A3	5.71e-06	9	83	3	GO:0015189
GeneOntologyMolecularFunction	L-arginine transmembrane transporter activity	SLC7A1 SLC7A2 SLC7A3	1.92e-05	13	83	3	GO:0061459
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC17A5 SLC7A1 SLC7A2 SLC7A3 SLC16A9 SLC38A11 SLC7A14	2.48e-05	207	83	7	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC17A5 SLC7A1 SLC7A2 SLC7A3 SLC16A9 SLC38A11 SLC7A14	2.56e-05	208	83	7	GO:0005342
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC17A5 SLC7A1 SLC7A2 SLC35A3 SLC7A3 SLC16A9 SLC38A11 SLC7A14	2.97e-05	293	83	8	GO:0008514
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC7A1 SLC7A2 SLC7A3 SLC38A11	2.18e-04	71	83	4	GO:0015179
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC7A1 SLC7A2 SLC7A3 SLC16A9	3.97e-04	83	83	4	GO:0015101
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1B CACNA1C	1.50e-03	14	83	2	GO:0008331
GeneOntologyBiologicalProcess	basic amino acid transmembrane transport	SLC7A1 SLC7A2 SLC7A4 SLC7A3	9.47e-07	19	84	4	GO:1990822
GeneOntologyBiologicalProcess	L-ornithine transmembrane transport	SLC7A1 SLC7A2 SLC7A3	1.29e-06	6	84	3	GO:1903352
GeneOntologyBiologicalProcess	basic amino acid transport	SLC7A1 SLC7A2 SLC7A4 SLC7A3	1.77e-06	22	84	4	GO:0015802
GeneOntologyBiologicalProcess	ornithine transport	SLC7A1 SLC7A2 SLC7A3	2.25e-06	7	84	3	GO:0015822
GeneOntologyBiologicalProcess	L-arginine import across plasma membrane	SLC7A1 SLC7A2 SLC7A3	3.60e-06	8	84	3	GO:0097638
GeneOntologyBiologicalProcess	L-lysine transmembrane transport	SLC7A1 SLC7A2 SLC7A3	7.66e-06	10	84	3	GO:1903401
GeneOntologyBiologicalProcess	L-lysine transport	SLC7A1 SLC7A2 SLC7A3	7.66e-06	10	84	3	GO:1902022
GeneOntologyBiologicalProcess	amino acid transmembrane transport	SLC7A1 SLC7A2 SLC7A4 SLC7A3 SLC38A11 SLC7A14	9.60e-06	120	84	6	GO:0003333
GeneOntologyBiologicalProcess	amino acid transport	SLC17A5 SLC7A1 SLC7A2 SLC7A4 SLC7A3 SLC38A11 SLC7A14	1.48e-05	195	84	7	GO:0006865
GeneOntologyBiologicalProcess	L-arginine transmembrane transport	SLC7A1 SLC7A2 SLC7A3	2.86e-05	15	84	3	GO:1903826
GeneOntologyBiologicalProcess	lysine transport	SLC7A1 SLC7A3	4.90e-05	3	84	2	GO:0015819
GeneOntologyBiologicalProcess	carboxylic acid transmembrane transport	SLC17A5 SLC7A1 SLC7A2 SLC7A3 SLC16A9 SLC38A11	5.43e-05	163	84	6	GO:1905039
GeneOntologyBiologicalProcess	organic acid transmembrane transport	SLC17A5 SLC7A1 SLC7A2 SLC7A3 SLC16A9 SLC38A11	6.21e-05	167	84	6	GO:1903825
GeneOntologyBiologicalProcess	disaccharide catabolic process	MGAM LCT	9.78e-05	4	84	2	GO:0046352
GeneOntologyBiologicalProcess	organic anion transport	SLC17A5 SLC7A1 SLC7A2 SLC35A3 SLC7A3 SLC16A9 PNPLA8 SLC38A11 SLC7A14	2.46e-04	515	84	9	GO:0015711
GeneOntologyBiologicalProcess	carboxylic acid transport	SLC17A5 SLC7A1 SLC7A2 SLC7A3 SLC16A9 PNPLA8 SLC38A11 SLC7A14	2.66e-04	410	84	8	GO:0046942
GeneOntologyBiologicalProcess	organic acid transport	SLC17A5 SLC7A1 SLC7A2 SLC7A3 SLC16A9 PNPLA8 SLC38A11 SLC7A14	2.74e-04	412	84	8	GO:0015849
GeneOntologyBiologicalProcess	import across plasma membrane	CACNA1B CACNA1C SLC7A1 SLC7A2 SLC7A3 SLC9A6	3.55e-04	230	84	6	GO:0098739
GeneOntologyBiologicalProcess	L-alpha-amino acid transmembrane transport	SLC7A1 SLC7A2 SLC7A3 SLC38A11	4.41e-04	87	84	4	GO:1902475
GeneOntologyBiologicalProcess	pantothenate metabolic process	PANK2 VNN2	4.52e-04	8	84	2	GO:0015939
Domain	CAT3	SLC7A1 SLC7A2 SLC7A4 SLC7A3 SLC7A14	1.63e-12	5	84	5	IPR015606
Domain	AA_permease_C	SLC7A1 SLC7A2 SLC7A4 SLC7A3 SLC7A14	1.63e-12	5	84	5	PF13906
Domain	CAT_C	SLC7A1 SLC7A2 SLC7A4 SLC7A3 SLC7A14	1.63e-12	5	84	5	IPR029485
Domain	AA_permease_2	SLC7A1 SLC7A2 SLC7A4 SLC7A3 SLC7A14	2.04e-09	13	84	5	PF13520
Domain	AA/rel_permease1	SLC7A1 SLC7A2 SLC7A4 SLC7A3 SLC7A14	2.04e-09	13	84	5	IPR002293
Domain	AA-permease/SLC12A_dom	SLC7A1 SLC7A2 SLC7A4 SLC7A3 SLC7A14	4.04e-08	22	84	5	IPR004841
Domain	AA_permease	SLC7A1 SLC7A2 SLC7A4 SLC7A3 SLC7A14	4.04e-08	22	84	5	PF00324
Domain	Cat_AA_permease	SLC7A1 SLC7A2 SLC7A3	8.78e-08	3	84	3	IPR004755
Domain	VDCC_a1su_IQ	CACNA1B CACNA1C	4.14e-04	7	84	2	IPR014873
Domain	GPHH	CACNA1B CACNA1C	4.14e-04	7	84	2	PF16905
Domain	GPHH_dom	CACNA1B CACNA1C	4.14e-04	7	84	2	IPR031649
Domain	Ca_chan_IQ	CACNA1B CACNA1C	4.14e-04	7	84	2	SM01062
Domain	Ca_chan_IQ	CACNA1B CACNA1C	4.14e-04	7	84	2	PF08763
Domain	VDCCAlpha1	CACNA1B CACNA1C	8.79e-04	10	84	2	IPR002077
Pubmed	Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4.	SLC7A1 SLC7A2 SLC7A4	1.41e-08	3	85	3	11665818
Pubmed	Differential topochemistry of three cationic amino acid transporter proteins, hCAT1, hCAT2 and hCAT3, in the adult human brain.	SLC7A1 SLC7A2 SLC7A3	1.41e-08	3	85	3	22870827
Pubmed	A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain.	SLC7A1 SLC7A2 SLC7A3	1.41e-08	3	85	3	9334265
Pubmed	Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines.	SLC7A1 SLC7A3	5.90e-06	2	85	2	9614060
Pubmed	Human cationic amino acid transporters are not affected by direct nitros(yl)ation.	SLC7A1 SLC7A2	5.90e-06	2	85	2	32008093
Pubmed	Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up.	SLC17A5 GOT1	5.90e-06	2	85	2	27872510
Pubmed	A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.	SLC7A2 SLC7A14	5.90e-06	2	85	2	22787143
Pubmed	Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver.	SLC7A1 SLC7A2	5.90e-06	2	85	2	8385111
Pubmed	The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.	SLC7A1 SLC7A2	5.90e-06	2	85	2	28684763
Pubmed	Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.	CACNA1B CACNA1C	5.90e-06	2	85	2	22590648
Pubmed	The importance of cationic amino acid transporter expression in human skin.	SLC7A1 SLC7A2	5.90e-06	2	85	2	12787129
Pubmed	Regulation of cationic amino acid transporter (CAT) gene expression.	SLC7A1 SLC7A2	5.90e-06	2	85	2	8878860
Pubmed	Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells.	SLC7A1 SLC7A2	5.90e-06	2	85	2	15064952
Pubmed	Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties.	SLC7A1 SLC7A2	5.90e-06	2	85	2	9174363
Pubmed	Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues.	SLC7A1 SLC7A3	5.90e-06	2	85	2	11591158
Pubmed	Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family.	SLC7A1 SLC7A2	5.90e-06	2	85	2	8195186
Pubmed	Characterization of cationic amino acid transporters (hCATs) 1 and 2 in human skin.	SLC7A1 SLC7A2	5.90e-06	2	85	2	18172665
Pubmed	Rate of transport of l-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells.	SLC7A1 SLC7A2	1.77e-05	3	85	2	15631944
Pubmed	Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization.	RALA EXOC8	1.77e-05	3	85	2	22761837
Pubmed	The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm.	CACNA1C TMEM161B	1.77e-05	3	85	2	33597309
Pubmed	Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.	CACNA1B CACNA1C	1.77e-05	3	85	2	26507659
Pubmed	Genome-wide association study identifies five new schizophrenia loci.	CACNA1C CSMD1 ITIH4	2.41e-05	23	85	3	21926974
Pubmed	A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.	CACNA1B CACNA1C	3.53e-05	4	85	2	15728831
Pubmed	Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.	CACNA1B CACNA1C	3.53e-05	4	85	2	19065143
Pubmed	MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.	SLC7A1 SLC7A2	3.53e-05	4	85	2	27357826
Pubmed	G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.	CACNA1B CACNA1C	3.53e-05	4	85	2	15953418
Pubmed	Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters.	SLC7A1 SLC7A2	5.87e-05	5	85	2	23009292
Pubmed	Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.	CACNA1B CACNA1C	5.87e-05	5	85	2	16787652
Pubmed	Sox6 regulation of cardiac myocyte development.	CACNA1C OCA2	5.87e-05	5	85	2	14530442
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1B CACNA1C	5.87e-05	5	85	2	15451373
Pubmed	Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase.	SLC7A1 SLC7A3	5.87e-05	5	85	2	16085056
Pubmed	Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo.	VIL1 LCT	5.87e-05	5	85	2	18211959
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1B CACNA1C	5.87e-05	5	85	2	11296258
Pubmed	The gene for the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1.	VIL1 CACNA1C	5.87e-05	5	85	2	1335956
Pubmed	Amino acid transport across mammalian intestinal and renal epithelia.	SLC7A1 SLC7A2 SLC7A3	6.03e-05	31	85	3	18195088
Pubmed	Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.	CACNA1B CACNA1C	8.80e-05	6	85	2	16029198
Pubmed	Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin.	CACNA1B CACNA1C	8.80e-05	6	85	2	11438518
Pubmed	Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.	B3GALT2 SLC35A3 MGAT5B	1.12e-04	38	85	3	2829950
Pubmed	Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.	CACNA1B CACNA1C	1.23e-04	7	85	2	21057379
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	CMTM6 CACNA1B ATP6V0B LIMD1 ZBTB25 IARS1 CSMD1 MGAT5B MOG	2.00e-04	832	85	9	36724073
Pubmed	The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.	RALA EXOC8	2.10e-04	9	85	2	11406615
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1B CACNA1C	2.10e-04	9	85	2	16382099
Pubmed	Ral GTPases regulate exocyst assembly through dual subunit interactions.	RALA EXOC8	2.62e-04	10	85	2	14525976
Pubmed	Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.	SLC7A2 CSMD1 PTCHD4	3.19e-04	54	85	3	24823311
Pubmed	Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.	SLC25A3 VIL1 CAD IARS1 HNRNPA3	3.39e-04	244	85	5	28902428
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	SLC25A3 HDAC3 CAD IARS1 HNRNPA3	4.37e-04	258	85	5	21081666
Pubmed	Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants.	RELN MAP2K5	5.27e-04	14	85	2	22442076
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1B CACNA1C	6.07e-04	15	85	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1B CACNA1C	6.07e-04	15	85	2	24453333
Pubmed	The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.	RALA EXOC8	6.07e-04	15	85	2	24056301
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SLC25A3 RALA CAD OXR1 DOCK8 IARS1 HNRNPA3 HAPLN2 CIT MOG GOT1	7.20e-04	1431	85	11	37142655
Pubmed	Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.	PLXNA3 RELN	7.84e-04	17	85	2	11683995
Pubmed	Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus.	RELN LCT	7.84e-04	17	85	2	33084572
Pubmed	RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.	RALA EXOC8	7.84e-04	17	85	2	21241894
Pubmed	SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study.	VIL1 CAD	8.80e-04	18	85	2	36877072
Pubmed	Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases.	VIL1 HDAC3	8.80e-04	18	85	2	15060137
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	CACNA1C PLCH2 CSMD1 SEZ6L2 ITIH4	9.02e-04	303	85	5	25056061
Pubmed	HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.	VIL1 LCT	9.83e-04	19	85	2	31345929
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CACNA1C RALA MALT1 SLC7A1 SLC35A3 SLC16A9 LIMD1 HNRNPA3 CSMD1 ADGRD1 RIC1	9.95e-04	1489	85	11	28611215
Pubmed	Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis.	SLC25A3 ZBTB2 HNRNPA3	1.05e-03	81	85	3	24657165
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	PLXNA3 CNTNAP2 CSMD1	1.16e-03	84	85	3	15203218
Pubmed	A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.	PARP6 CACNA1B CIT	1.20e-03	85	85	3	23055939
Pubmed	An atlas of genetic influences on human blood metabolites.	MGAM FMO3 SLC16A9 NASP	1.24e-03	190	85	4	24816252
Pubmed	Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice.	FBN2 BBOX1	1.32e-03	22	85	2	22837474
Pubmed	Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.	SLC35A3 MGAT5B	1.44e-03	23	85	2	1736542
Pubmed	Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.	SLC35A3 MGAT5B	1.44e-03	23	85	2	8093218
Pubmed	Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.	SLC35A3 MGAT5B	1.44e-03	23	85	2	3099781
Pubmed	Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.	SLC35A3 MGAT5B	1.44e-03	23	85	2	3264072
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	SLC25A3 CAD CNTNAP2 CIT	1.55e-03	202	85	4	33005030
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CACNA1B CACNA1C OXR1 HNRNPA3 CIT	1.64e-03	347	85	5	17114649
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	RELN THBS2 HAPLN2 PAPLN	1.79e-03	210	85	4	16537572
Pubmed	Control of TurboID-dependent biotinylation intensity in proximity ligation screens.	HDAC3 ERN1 CIT	1.92e-03	100	85	3	36966971
Pubmed	Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.	OR5H2 OR5AR1	1.99e-03	27	85	2	32061665
Pubmed	Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.	MAP2K5 ITIH4	2.14e-03	28	85	2	24861553
Pubmed	Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.	IARS1 HNRNPA3 NASP	2.21e-03	105	85	3	22505724
Pubmed	Blood-Brain Barrier: From Physiology to Disease and Back.	SLC7A1 SLC7A2 SLC7A3	2.21e-03	105	85	3	30280653
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	ZBTB2 CAD ZBTB25	2.27e-03	106	85	3	19394292
Pubmed	Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.	RELN CNTNAP2 CIT MOG GOT1	2.33e-03	376	85	5	24154525
GeneFamily	Solute carriers	SLC25A3 SLC17A5 SLC7A1 SLC7A2 SLC7A4 SLC35A3 SLC7A3 SLC16A9 SLC38A11 SLC7A14 SLC9A6	3.53e-08	395	57	11	752
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GABRP SLC7A4 FMO3 PAPLN MUC5B CSMD1	5.71e-07	157	85	6	c43f2e1ea53b375a7432f17f87cfef3b2261003d
ToppCell	(03)_Secretory\|World / shred by cell type and Timepoint	GABRP SLC7A2 SLC35A3 FMO3 MUC5B UNC93B1	1.11e-06	176	85	6	cb7b1945788196ca79007f0768b6576ec885a0e5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VIL1 MGAM SLC16A9 PLCH2 CSMD1 BBOX1	1.11e-06	176	85	6	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	B3GALT2 SLC7A2 RELN SLC7A3 FBN2 PTCHD4	1.85e-06	192	85	6	f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	B3GALT2 SLC7A2 RELN SLC7A3 FBN2 PTCHD4	1.85e-06	192	85	6	690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CACNA1B SLC7A4 RELN CNTNAP2 OCA2 KCNT1	2.34e-06	200	85	6	2f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CACNA1B SLC7A4 RELN CNTNAP2 OCA2 KCNT1	2.34e-06	200	85	6	bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CACNA1B SLC7A4 RELN CNTNAP2 OCA2 KCNT1	2.34e-06	200	85	6	dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B FBN2 CNTNAP2 MUC5B PTCHD4	1.39e-05	160	85	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B FBN2 CNTNAP2 MUC5B PTCHD4	1.39e-05	160	85	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Nasal_Brush-Immune-Dendritic_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	RALA ATP6V0B HNRNPA3	1.64e-05	26	85	3	e83bba14028e7684beb3dd0ec5ecf8c88245a202
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1B SLC16A9 CNTNAP2 CSMD1 MMD2	1.71e-05	167	85	5	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B GABRP IL13RA1 LIMD1 CSMD1	1.76e-05	168	85	5	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXNA3 MALT1 SLC7A3 MMD2 CSMD1	2.14e-05	175	85	5	d67c77eee979ad029e7545f383326f0ff77c6e5f
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXNA3 MALT1 SLC7A3 MMD2 CSMD1	2.14e-05	175	85	5	1d1cdbf3221b03e24eae38afd57cbd6736b37a53
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1B CACNA1C TMEM161B KCNT1 ITIH4	2.26e-05	177	85	5	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	E16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VIL1 GABRP SLC38A11 SEZ6L2 SLC7A14	2.33e-05	178	85	5	d3a75a8082e70543b84c35d53fe77625300d19fa
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALT2 GABRP FMO3 FBN2 MUC5B	2.33e-05	178	85	5	b89c4d015b44bf538aa39969ef8778877c8023f1
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALT2 GABRP FMO3 FBN2 MUC5B	2.33e-05	178	85	5	fb8f8d95f6b08378fb42c4076ee040276faa296f
ToppCell	E16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VIL1 GABRP SLC38A11 SEZ6L2 SLC7A14	2.33e-05	178	85	5	b2cda1df801b1a1a41e3dd2808baef37765cd804
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VIL1 SLC16A9 PLCH2 CSMD1 BBOX1	2.59e-05	182	85	5	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM SLC16A9 PLCH2 CSMD1 BBOX1	2.66e-05	183	85	5	d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALT2 GABRP FMO3 PLCH2 MUC5B	2.73e-05	184	85	5	45ff845ceed5960a997545c1009012b65e377d50
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM RELN FBN2 MUC5B CSMD1	2.73e-05	184	85	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM RELN FBN2 MUC5B CSMD1	2.73e-05	184	85	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM RELN FBN2 MUC5B CSMD1	2.73e-05	184	85	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial-respiratory_basal_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALT2 GABRP FMO3 PLCH2 MUC5B	2.73e-05	184	85	5	2cc2646dee3c6001f7c10b7449c17d1935021958
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	RELN THBS2 FBN2 CSMD1 ADGRD1	2.80e-05	185	85	5	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	Club\|World / Class top	GABRP SLC7A2 FMO3 MUC5B UNC93B1	2.80e-05	185	85	5	c3caf789e622ed515d143dc594158d52fdcffaef
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALT2 GABRP FMO3 PLCH2 MUC5B	2.87e-05	186	85	5	37b93ebd64ebbd08193a746e5bc9b350c2570733
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1B CNTNAP2 HAPLN2 PTCHD4 SLC7A14	2.87e-05	186	85	5	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	Club-club-14\|World / Class top	GABRP SLC7A2 FMO3 MUC5B UNC93B1	2.95e-05	187	85	5	4584de577d3736c89187e522497498e58d381c46
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C SLC7A2 THBS2 FMO3 ABCA9	2.95e-05	187	85	5	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALT2 GABRP FMO3 PLCH2 MUC5B	3.02e-05	188	85	5	8ffb5394f7b00ea483a5fe4df894d22fda935e5c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IL13RA1 SLC7A2 SLC7A3 FBN2 PTCHD4	3.02e-05	188	85	5	4544552ebd67e9eb3e40d8511bb2b03a6e1178f8
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALT2 GABRP FMO3 PLCH2 MUC5B	3.02e-05	188	85	5	137ed9958044fab7a13648affb469585d1c48cf6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC7A2 DOCK8 HAPLN2 SLC38A11 KCNT1	3.10e-05	189	85	5	fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCell	Neuroendocrine-neuroendo-2-Calca\|World / Class top	VIL1 SLC38A11 PTCHD4 SEZ6L2 SLC7A14	3.10e-05	189	85	5	6baa9a74560121cc008bb8fa9b2b7a335b3aeee0
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IL13RA1 SLC7A3 FBN2 SLC16A9 PTCHD4	3.18e-05	190	85	5	2f54da2bee411f8868348a4c37034184b8f58a89
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A2 RELN SLC7A3 FBN2 PTCHD4	3.18e-05	190	85	5	3b8d1e66ae68c1eee64095e75195d76d97e24026
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C SLC7A2 THBS2 PAPLN ADGRD1	3.18e-05	190	85	5	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	facs-Trachea-24m-Epithelial-airway_epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALT2 GABRP FMO3 PLCH2 MUC5B	3.18e-05	190	85	5	576c45a30a4808b47433bc6c2c41396135556c40
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A2 RELN SLC7A3 FBN2 PTCHD4	3.18e-05	190	85	5	dc655e4782aab274f0c9b6e36a5ce315e3a1a4b9
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 RELN CNTNAP2 SEZ6L2 SLC7A14	3.26e-05	191	85	5	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	Neuroendocrine\|World / Class top	VIL1 SLC38A11 PTCHD4 SEZ6L2 SLC7A14	3.34e-05	192	85	5	0199da3ef9ddb6673e9aa41f346f374838aec182
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VIL1 SLC16A9 PLCH2 CSMD1 BBOX1	3.34e-05	192	85	5	3e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A2 RELN CNTNAP2 PTCHD4 SEZ6L2	3.34e-05	192	85	5	bf1943715085c4124b1675888b0615c9500ec888
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THBS2 FBN2 MGAT5B ABCA9 ADGRD1	3.42e-05	193	85	5	549a0b750c860b615aff767ad04c9a9d20f802f0
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A2 RELN SLC7A3 FBN2 PTCHD4	3.42e-05	193	85	5	294cb5b580bb83fe0eb04f112d5507aac35d4d44
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A2 RELN SLC7A3 FBN2 PTCHD4	3.42e-05	193	85	5	3d3c45d5ff6f3396a1990615aae9fe176e799994
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CMTM6 RALA MALT1 IL13RA1 CSMD1	3.51e-05	194	85	5	bde6830a281f7cd7fd1733e40a41ddd2673ba88e
ToppCell	COVID-19-kidney-Fibroblast-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C SLC7A2 THBS2 FMO3 ABCA9	3.60e-05	195	85	5	3d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B CACNA1C OXR1 CNTNAP2 CSMD1	3.69e-05	196	85	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VIL1 MGAM SLC16A9 PLCH2 BBOX1	3.69e-05	196	85	5	4ebcaac758ed01d918de9c1cd383a84457b615f3
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CMTM6 RALA MALT1 IL13RA1 CSMD1	3.78e-05	197	85	5	a902aa05e5f711bcfdd9e19749ab636b597eb116
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B CACNA1C OXR1 CNTNAP2 CSMD1	3.87e-05	198	85	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B CACNA1C OXR1 CNTNAP2 CSMD1	3.87e-05	198	85	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B CACNA1C OXR1 CNTNAP2 CSMD1	3.87e-05	198	85	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B CACNA1C OXR1 CNTNAP2 CSMD1	3.87e-05	198	85	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	COVID-19-kidney-Fibroblast-2\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1C SLC7A2 THBS2 FMO3 ABCA9	3.87e-05	198	85	5	ca26ca460856b1faaa3e83766da6abdf63af2b51
ToppCell	Parenchyma_COVID-19-Immune-TX-MoAM-4\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	HMSD RALA IL13RA1 ATP6V0B OXR1	3.87e-05	198	85	5	a7eed9eeb728a8796e2780090cc244856efd8c65
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B CACNA1C OXR1 CNTNAP2 CSMD1	3.87e-05	198	85	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	COVID-19-kidney-Fibroblast-1\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1C SLC7A2 THBS2 FMO3 ABCA9	3.96e-05	199	85	5	9503646ff1ad248181146ce767e9d12e882ec3bd
ToppCell	Neuronal-Inhibitory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC7A2 RELN FBN2 CNTNAP2 PTCHD4	4.06e-05	200	85	5	9ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1B CACNA1C OXR1 CNTNAP2 CSMD1	4.06e-05	200	85	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	THBS2 MUC5B MGAT5B ABCA9 ADGRD1	4.06e-05	200	85	5	29054cf55e88e1ac81a562d8dd9af9b7c749321d
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PLXNA3 GABRP MUC5B BBOX1	5.47e-05	108	85	4	9c7f3e25facfb54ef0be45044999bc36438bbea0
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_submucosal-gland\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PLXNA3 GABRP MUC5B BBOX1	5.47e-05	108	85	4	75d635fc5bb004418db2e1328c24d96b718f10b1
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXNA3 MALT1 KMT5C MMD2	9.08e-05	123	85	4	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1B RELN CNTNAP2 MMD2	1.06e-04	128	85	4	91072ca56bce2c552a95edd67e17f43d8cc1de95
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	RELN FBN2 CNTNAP2 CSMD1	1.76e-04	146	85	4	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	COVID-19-kidney-Technical/muscle\|kidney / Disease (COVID-19 only), tissue and cell type	RELN FBN2 CNTNAP2 OCA2	1.85e-04	148	85	4	0dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell	E18.5-samps-Mesenchymal-Pericyte-pericyte_C\|E18.5-samps / Age Group, Lineage, Cell class and subclass	IL13RA1 SLC38A11 MMD2 PTCHD4	2.00e-04	151	85	4	3f2abaa42876ce7a71d934ff16abe0cab0991a05
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RELN SLC7A3 SLC16A9 PTCHD4	2.15e-04	154	85	4	c6ecc46b99a783373729f7fae0b23216148ffb78
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PANK2 SLC16A9 ERN1 ABCA9	2.26e-04	156	85	4	d72c2f5f72d269e29033f8728d924e0d4c8772c7
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO3 OCA2 ABCA9 ITIH4	2.32e-04	157	85	4	7fdc0094dd5729990a91a30c1982a14c74650b52
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-microglial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO3 OCA2 ABCA9 ITIH4	2.32e-04	157	85	4	c762b03e254c73222094725ca8ac1c8eb428bccb
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO3 OCA2 ABCA9 ITIH4	2.32e-04	157	85	4	6b5b08bb5520fcf6f4c0560f7ed7645ec179806d
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1B RELN CNTNAP2 CSMD1	2.43e-04	159	85	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	PND01-03-samps-Myeloid-Macrophage-CD163+_Macrophage\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	UNC93B1 CIT ABCA9 GOT1	2.49e-04	160	85	4	4480a7d6bd48d06b4e5196faac868f31ab7ed3ad
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Club_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	GABRP FMO3 PLCH2 MUC5B	2.61e-04	162	85	4	aed15eef32419b8a4e2afdb9776c2bf2802e96f1
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D231\|Adult / Lineage, Cell type, age group and donor	CACNA1C PAPLN OCA2 ABCA9	2.74e-04	164	85	4	3d8ff70fe5582d1fb56b338be8b76fa1428b3657
ToppCell	Adult-Mesenchymal-chondrocyte-D231\|Adult / Lineage, Cell type, age group and donor	CACNA1C THBS2 SEZ6L2 ABCA9	2.74e-04	164	85	4	2ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B SLC7A2 SLC38A11 SLC7A14	3.00e-04	168	85	4	4e1b522c7400c9d87f63c00e4e1dd07136095cd6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS2 KCNT1 ABCA9 ADGRD1	3.00e-04	168	85	4	4b2d29a7843bf45922038c093ca7ec0600756adc
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-stromal_related-FDC\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HMSD PAPLN OCA2 SDR9C7	3.07e-04	169	85	4	49a54fb2ea9db5c45e107f304838c536908308bb
ToppCell	facs-Lung-EPCAM-3m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRP SLC7A4 FMO3 OCA2	3.14e-04	170	85	4	82ccba6ec53f6ca0d19949a1277434c565af2983
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRP SLC7A4 FMO3 OCA2	3.14e-04	170	85	4	ab19ea729ed8c8361c870e79893d1a95a1e487fa
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C SLC7A2 PAPLN ADGRD1	3.14e-04	170	85	4	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FMO3 SLC38A11 ABCA9 ADGRD1	3.21e-04	171	85	4	a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCell	droplet-Lung-nan-18m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALT2 GABRP SLC7A4 FMO3	3.21e-04	171	85	4	3b02dc5609f5bcd055b532bb4631d2a7183804e9
ToppCell	facs-Trachea-nan-24m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRP FMO3 PLCH2 MUC5B	3.21e-04	171	85	4	d2a10e94b0490120d1420b944302eb841f902c64
ToppCell	droplet-Lung-nan-18m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALT2 GABRP SLC7A4 FMO3	3.21e-04	171	85	4	88309bfb1cf427783c853dfd6709cd5edc9074b9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS2 KCNT1 ABCA9 ADGRD1	3.21e-04	171	85	4	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C THBS2 SLC38A11 CSMD1	3.21e-04	171	85	4	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RELN CNTNAP2 MMD2 CSMD1	3.21e-04	171	85	4	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	CACNA1C DOCK8 OCA2 SLC38A11	3.21e-04	171	85	4	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FSD1L HAPLN2 SEZ6L2 MOG	3.35e-04	173	85	4	b413a8554868e3c09275948b6605f7dc7f7277fd
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C HAPLN2 KCNT1 SDR9C7	3.35e-04	173	85	4	5416b092321c7d9b63f0418c60f2402a138355bf
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HMSD MGAM RELN MMD2	3.35e-04	173	85	4	922356a5b4c84607318ac24d7caa2e235b72b066
Drug	L-Lysine	SLC7A1 SLC7A2 SLC7A4 SLC7A3	8.59e-10	5	84	4	DB00123
Drug	naBE	MGAM SLC7A1 SLC7A2 SLC7A4 SLC7A3	3.62e-09	17	84	5	CID000151475
Drug	dl-ornithine	DPAGT1 SLC7A1 SLC7A2 SLC7A4 CAD SLC7A3 CIT SLC7A14 GOT1	3.18e-08	188	84	9	CID000000389
Drug	3-iodothyronamine	SLC17A5 SLC7A1 SLC7A2 SLC7A14 SLC9A6	1.33e-07	33	84	5	ctd:C487948
Drug	L-Ornithine	SLC7A1 SLC7A2 SLC7A4 SLC7A3	1.68e-07	14	84	4	DB00129
Drug	8a beta-indolizidine-1 alpha, 2 alpha, 8 beta-triol	B3GALT2 DPAGT1 MGAM LCT ITIH4 GOT1	1.32e-06	94	84	6	CID000005363
Drug	L-Arginine	SLC7A1 SLC7A4 SLC7A3	4.00e-06	9	84	3	DB00125
Drug	acetonate	MGAM SLC7A1 CIT	1.35e-05	13	84	3	CID000011671
Drug	butamben	CACNA1B CACNA1C MGAM	2.13e-05	15	84	3	CID000002482
Drug	NSC-711994	MGAM ITIH4	4.03e-05	3	84	2	CID005471614
Drug	sodium	SLC25A3 CACNA1C GABRP MGAM SLC7A1 SLC7A2 SLC7A4 ATP6V0B SLC7A3 CNTNAP2 CIT SLC7A14 SLC9A6	4.03e-05	944	84	13	CID000000923
Drug	AC1LABND	HDAC3 SLC7A1 SLC7A3 CIT	4.74e-05	54	84	4	CID000485098
Disease	progression free survival, ovarian serous carcinoma	MGAM PNPLA8 PTCHD4	3.18e-05	22	83	3	EFO_0004920, EFO_1001516
Disease	bitter alcoholic beverage consumption measurement	MGAM RELN CNTNAP2 CSMD1 SEZ6L2	3.78e-05	133	83	5	EFO_0010092
Disease	deoxycarnitine measurement	SLC16A9 BBOX1	1.16e-04	6	83	2	EFO_0800259
Disease	pantothenate measurement	CAD PANK2	2.16e-04	8	83	2	EFO_0021034
Disease	Anemia, Sickle Cell	CACNA1C CAD	3.47e-04	10	83	2	C0002895
Disease	dipeptidase 2 measurement	DUS2 ITIH4	3.47e-04	10	83	2	EFO_0801528
Disease	Schizophrenia	CACNA1B CACNA1C HDAC3 RELN PANK2 HNRNPA3 CNTNAP2 CSMD1 MOG	8.40e-04	883	83	9	C0036341
Disease	interstitial lung disease	DUS2 MUC5B CSMD1	9.03e-04	67	83	3	EFO_0004244
Disease	Polyposis, Adenomatous Intestinal	FMO3 ITIH4	9.14e-04	16	83	2	C2713442
Disease	Familial Intestinal Polyposis	FMO3 ITIH4	9.14e-04	16	83	2	C2713443
Disease	aspartate aminotransferase measurement	SLC25A3 SLC17A5 TBC1D9B PANK2 CNTNAP2 WDR55 CSMD1 LCT GOT1	9.90e-04	904	83	9	EFO_0004736
Disease	phosphatidylcholine 40:6 measurement	TMTC4 CSMD1	1.03e-03	17	83	2	EFO_0010389
Disease	Adenomatous Polyposis Coli	FMO3 ITIH4	1.03e-03	17	83	2	C0032580
Disease	anorectal malformation	THBS2 MUC5B	1.30e-03	19	83	2	MONDO_0019938
Disease	Involutional paraphrenia	CACNA1C RELN	2.25e-03	25	83	2	C1571983
Disease	Psychosis, Involutional	CACNA1C RELN	2.25e-03	25	83	2	C1571984
Disease	Involutional Depression	CACNA1C RELN	2.25e-03	25	83	2	C0011574
Disease	alpha-linolenic acid measurement	CSMD1 LCT	2.25e-03	25	83	2	EFO_0007759
Disease	Bipolar Disorder	CACNA1B CACNA1C RELN CNTNAP2 CSMD1 ITIH4	2.29e-03	477	83	6	C0005586
Disease	psychosis predisposition measurement	CACNA1C CSMD1	2.43e-03	26	83	2	EFO_0008337
Disease	alcohol consumption measurement	CACNA1C MGAM RELN CAD TMEM161B PAPLN CSMD1 SEZ6L2 MAP2K5 CIT	2.52e-03	1242	83	10	EFO_0007878
Disease	L-arginine measurement	VIL1 SLC7A2	2.62e-03	27	83	2	EFO_0006524

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRGATTFFAFCYPFS	AGBL5	146	Q8NDL9
FGVGDSLTFSCFLGY	CSMD1	1061	Q96PZ7
VFVYCAFLDFSSGEG	ADGRD1	506	Q6QNK2
VAQGGVATDFFIFFC	ABCA9	216	Q8IUA7
FLGVTELSAYCEGYF	BTBD11	1036	A6QL63
TASCFYAFVGFDVIA	SLC7A4	241	O43246
YAFVGFDCIATTGEE	SLC7A2	266	P52569
YFRSSFNCFDFGVIV	CACNA1B	541	Q00975
FNCFDFGVIVGSVFE	CACNA1B	546	Q00975
LLCFHEFGVFVDSYG	CIT	1801	O14578
SLFCLGFGFDVSYAF	ITIH4	411	Q14624
FDGDRYSFEGSCEYI	MUC5B	906	Q9HC84
NYFRSGEGFLCVFSI	RALA	81	P11233
ILVAIFSETGFFDYC	OCA2	396	Q04671
YCATLDGFAVVFNDG	RIC1	211	Q4ADV7
DIAFYFSGFCVLLGG	SLC16A9	461	Q7RTY1
AAQFFFFVGFATVEC	OR5B21	96	A6NL26
GTIYVFFFHERTGSC	MMD2	146	Q8IY49
VEEQYSCDYGSGRFF	SLC25A3	51	Q00325
GIDCVIFATGYSFAY	FMO3	321	P31513
NGKVFCEEDFLYSGF	LIMD1	516	Q9UGP4
YDAFCFTSALAGQVF	HAPLN2	236	Q9GZV7
IVFGYATCQGAEAFE	MALT1	486	Q9UDY8
DEVTCFYGEGFFGEK	KMT5C	211	Q86Y97
IGVFCDFDGGQLSFY	FSD1L	451	Q9BXM9
LFGISYTGADICGFF	MGAM	1546	O43451
YTGADICGFFQDAEY	MGAM	1551	O43451
SYTGADICGFFQDAE	MGAM	2446	O43451
FYFCIVTFSTVGYGD	KCNT1	286	Q5JUK3
AFFGVDGTECSFLIY	MGAT5B	186	Q3V5L5
GDTFCYFAGMTFAVV	DPAGT1	251	Q9H3H5
VRFAGADFVFYNCSV	PLXNA3	626	P51805
GFYGAFFVENRISIC	MAP2K5	226	Q13163
GIIDVVATFSFSYCG	OR2M3	156	Q8NG83
FFSFAFGGTTECFLL	OR5H2	106	Q8NGV7
DYAAFCFSTFGDRVK	LCT	521	P09848
IDFAGTDSGCYSAFV	EXOC8	476	Q8IYI6
VFPGLFEFCSRYTGA	HDAC3	96	O15379
DEGGFTCFFRDHSYQ	MOG	121	Q16653
KYGETANECGEAFFF	NASP	76	P49321
ANECGEAFFFYGKSL	NASP	81	P49321
IFREGQYFGCSFDLT	IL13RA1	176	P78552
FYSIRGAEVSFGCGV	RELN	726	P78509
FCATGGGAYKFEQDF	PANK2	311	Q9BZ23
GTGETFVFTFCPEFE	OXR1	791	Q8N573
FCSGTGYVFSGDLAE	B3GALT2	311	O43825
GETPCGSSFAVFYFI	CACNA1C	1491	Q13936
AFYGQCFGAEFVEVI	DOCK8	1831	Q8NF50
GYCVSKFGVEAFSDS	SDR9C7	171	Q8NEX9
DIFSAGCVFYYVISE	ERN1	756	O75460
FVDFTDIGVDYCDFS	BBOX1	256	O75936
IRYFVSEGFEFFCAQ	GOT1	241	P17174
DFLTGFTDSCGKFYQ	HMSD	71	A8MTL9
YDGTFCNKDVGAFFE	CNTNAP2	996	Q9UHC6
GFTVDAFQYGVVEGC	DCLRE1A	711	Q6PJP8
SSREICEAFGLGAFY	DUS2	306	Q9NX74
CEAFGLGAFYEETTQ	DUS2	311	Q9NX74
GSFECECFEGYESGF	FBN2	1136	P35556
AVFLVAAGFIGCDYS	SLC17A5	376	Q9NRA2
TFTGFTQGDLFENYC	SLC38A11	221	Q08AI6
FYAFVGFDCIATTGE	SLC7A3	261	Q8WY07
IDVYLGICFSFVFGA	GABRP	306	O00591
GICFSFVFGALLEYA	GABRP	311	O00591
CTRFFFVYEDGQVGD	PARP6	591	Q2NL67
FDYICGVSTGAILAF	PNPLA8	476	Q9NP80
LAGDFYFTDCLLFGA	SLC9A6	211	Q92581
GERSVCVTFGFFFFV	TMEM161B	166	Q8NDZ6
YIFSFFGSCLVFAGQ	PTCHD4	381	Q6ZW05
GCFTTEVTDFAGQYV	IARS1	356	P41252
AGESLRFFCYEGFEL	SEZ6L2	791	Q6UXD5
RFFCYEGFELIGEVT	SEZ6L2	796	Q6UXD5
FAFFVGFVDAECYVL	OR5AR1	101	Q8NGP9
FESAVVIVDCFFYEG	TBC1D9B	681	Q66K14
GGLYFFEFVSCSAFL	CMTM6	66	Q9NX76
GFLCDCTVAIGDVYF	ZBTB25	21	P24278
QGAATCFYAFIGFDI	SLC7A14	256	Q8TBB6
CFYAFIGFDIIATTG	SLC7A14	261	Q8TBB6
TAFGRFGIFTCFDIF	VNN2	201	O95498
IVCFARSYDGDFVFD	TMTC4	31	Q5T4D3
TFGSFFDGDCYIILA	VIL1	36	P09327
FFIYSGFEVLFACTG	UNC93B1	346	Q9H1C4
VFSEFNRYLFNCGEG	ELAC2	76	Q9BQ52
RVAVEDGGFYTCVAF	PAPLN	1101	O95428
LSGAATCFYAFVGFD	SLC7A1	256	P30825
DHQGTLGFEEFCAFY	PLCH2	221	O75038
AVGVCYTIFDLGFRF	ATP6V0B	21	Q99437
RGFGFVTYSCVEEVD	HNRNPA3	76	P51991
RFGSTQEYEACFGQF	CAD	2151	P27708
GDVDGDVFVFSYSCQ	WDR55	56	Q9H6Y2
TACFSSGFAGVYFEK	SLC35A3	181	Q9Y2D2
GFLCDCTVAIGDVYF	ZBTB2	21	Q8N680
LFTGAAVSICEGAYF	TMEM72	46	A0PK05
GFDEFGSVDFSGTFY	THBS2	1001	P35442