Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribonuclease III activity	DROSHA DICER1	1.69e-05	3	48	2	GO:0004525
GeneOntologyMolecularFunction	double-stranded RNA-specific ribonuclease activity	DROSHA DICER1	1.69e-05	3	48	2	GO:0032296
GeneOntologyMolecularFunction	laminin-1 binding	SLIT2 PXDN	1.57e-04	8	48	2	GO:0043237
GeneOntologyMolecularFunction	siRNA binding	TLR9 DICER1	3.68e-04	12	48	2	GO:0035197
GeneOntologyMolecularFunction	axon guidance receptor activity	EPHB3 EPHB1	4.34e-04	13	48	2	GO:0008046
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EPHB3 NRG2 EPHB1	5.13e-04	65	48	3	GO:0004714
GeneOntologyMolecularFunction	transmembrane-ephrin receptor activity	EPHB3 EPHB1	5.82e-04	15	48	2	GO:0005005
GeneOntologyMolecularFunction	extracellular matrix binding	SLIT2 PXDN ZAN	7.20e-04	73	48	3	GO:0050840
GeneOntologyMolecularFunction	ephrin receptor activity	EPHB3 EPHB1	9.43e-04	19	48	2	GO:0005003
GeneOntologyMolecularFunction	SUMO binding	HERC2 RNF111	9.43e-04	19	48	2	GO:0032183
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	EPHB3 NRG2 EPHB1	1.12e-03	85	48	3	GO:0019199
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	RNF112 RNF44 RNF38 HERC2 RNF111	1.94e-03	372	48	5	GO:0061630
GeneOntologyMolecularFunction	heparan sulfate proteoglycan binding	SLIT2 FBLN7	2.20e-03	29	48	2	GO:0043395
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RNF112 RNF44 RNF38 HERC2 RNF111	2.60e-03	398	48	5	GO:0061659
GeneOntologyMolecularFunction	laminin binding	SLIT2 PXDN	3.02e-03	34	48	2	GO:0043236
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	DROSHA DICER1	3.57e-03	37	48	2	GO:0016891
GeneOntologyBiologicalProcess	columnar/cuboidal epithelial cell development	TYMS BMP6 TLR9 DICER1	2.00e-05	69	48	4	GO:0002066
GeneOntologyBiologicalProcess	intestinal epithelial cell development	TYMS TLR9 DICER1	2.31e-05	24	48	3	GO:0060576
GeneOntologyBiologicalProcess	retinal ganglion cell axon guidance	EPHB3 SLIT2 EPHB1	2.31e-05	24	48	3	GO:0031290
GeneOntologyBiologicalProcess	digestive tract development	EPHB3 TYMS TLR9 DICER1 ALX4	2.70e-05	152	48	5	GO:0048565
GeneOntologyBiologicalProcess	digestive system development	EPHB3 TYMS TLR9 DICER1 ALX4	4.23e-05	167	48	5	GO:0055123
GeneOntologyBiologicalProcess	central nervous system projection neuron axonogenesis	EPHB3 SLIT2 EPHB1	5.59e-05	32	48	3	GO:0021952
GeneOntologyBiologicalProcess	tube development	EPHB3 TYMS SLIT2 KIF18A PXDN DPPA4 LRP2 TLR9 STIL DICER1 ALX4 EPHB1	6.52e-05	1402	48	12	GO:0035295
GeneOntologyBiologicalProcess	intestinal epithelial cell differentiation	TYMS TLR9 DICER1	6.73e-05	34	48	3	GO:0060575
GeneOntologyBiologicalProcess	male sex differentiation	KIF18A BMP6 LRP2 RNF38 TLR9	9.72e-05	199	48	5	GO:0046661
GeneOntologyBiologicalProcess	central nervous system neuron axonogenesis	EPHB3 SLIT2 EPHB1	1.37e-04	43	48	3	GO:0021955
GeneOntologyBiologicalProcess	central nervous system neuron differentiation	EPHB3 SLIT2 OLIG3 DICER1 EPHB1	1.46e-04	217	48	5	GO:0021953
GeneOntologyBiologicalProcess	reproductive structure development	KIF18A BMP6 LRP2 RNF38 TLR9 DICER1	2.50e-04	383	48	6	GO:0048608
GeneOntologyBiologicalProcess	sensory organ development	CACNA1S BMP6 OLIG3 PXDN KERA LAMC3 DICER1 EPHB1	2.55e-04	730	48	8	GO:0007423
GeneOntologyBiologicalProcess	reproductive system development	KIF18A BMP6 LRP2 RNF38 TLR9 DICER1	2.68e-04	388	48	6	GO:0061458
GeneOntologyBiologicalProcess	epithelial cell development	TYMS BMP6 TLR9 KDF1 DICER1	3.94e-04	269	48	5	GO:0002064
GeneOntologyBiologicalProcess	positive regulation of nervous system development	EPHB3 SLIT2 RNF112 LRP2 DICER1 EPHB1	3.99e-04	418	48	6	GO:0051962
GeneOntologyCellularComponent	dendrite	EPHB3 SLIT2 CACNA1S SORBS2 GRK4 LRP2 DICER1 EPHB1	5.91e-04	858	47	8	GO:0030425
GeneOntologyCellularComponent	dendritic tree	EPHB3 SLIT2 CACNA1S SORBS2 GRK4 LRP2 DICER1 EPHB1	6.00e-04	860	47	8	GO:0097447
GeneOntologyCellularComponent	extracellular matrix	SLIT2 FBLN7 CTSF PXDN ZAN KERA LAMC3	6.13e-04	656	47	7	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	SLIT2 FBLN7 CTSF PXDN ZAN KERA LAMC3	6.24e-04	658	47	7	GO:0030312
Domain	NPIP	NPIPA5 NPIPA1 NPIPA3 NPIPA7 NPIPA2	2.70e-10	14	52	5	IPR009443
Domain	EGF-like_CS	SLIT2 FBLN7 ZAN LRP2 NRG2 LAMC3 EPHB1	7.51e-06	261	52	7	IPR013032
Domain	EGF_2	SLIT2 FBLN7 ZAN LRP2 NRG2 LAMC3 EPHB1	8.30e-06	265	52	7	PS01186
Domain	Ribonuclease_3	DROSHA DICER1	2.28e-05	3	52	2	PF00636
Domain	RIBOc	DROSHA DICER1	2.28e-05	3	52	2	SM00535
Domain	RNase_III_dom	DROSHA DICER1	2.28e-05	3	52	2	IPR000999
Domain	RNASE_3_1	DROSHA DICER1	2.28e-05	3	52	2	PS00517
Domain	RNASE_3_2	DROSHA DICER1	2.28e-05	3	52	2	PS50142
Domain	-	DROSHA DICER1	2.28e-05	3	52	2	1.10.1520.10
Domain	EGF	SLIT2 FBLN7 ZAN LRP2 NRG2	2.60e-05	126	52	5	PF00008
Domain	EGF	SLIT2 FBLN7 ZAN LRP2 NRG2 LAMC3	4.67e-05	235	52	6	SM00181
Domain	-	EPHB3 LAMC3 HERC2 EPHB1	5.04e-05	73	52	4	2.60.120.260
Domain	EGF-like_dom	SLIT2 FBLN7 ZAN LRP2 NRG2 LAMC3	6.44e-05	249	52	6	IPR000742
Domain	EGF_1	SLIT2 FBLN7 ZAN LRP2 NRG2 LAMC3	7.35e-05	255	52	6	PS00022
Domain	Galactose-bd-like	EPHB3 LAMC3 HERC2 EPHB1	1.35e-04	94	52	4	IPR008979
Domain	zf-RING_2	RNF44 RNF38 RNF111	4.09e-04	52	52	3	PF13639
Domain	LRR_6	KERA TLR9 NLRP3	4.82e-04	55	52	3	PF13516
Domain	EGF_3	SLIT2 FBLN7 ZAN LRP2 NRG2	4.85e-04	235	52	5	PS50026
Domain	RECEPTOR_TYR_KIN_V_2	EPHB3 EPHB1	6.77e-04	14	52	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB3 EPHB1	6.77e-04	14	52	2	PS00790
Domain	Eph_TM	EPHB3 EPHB1	6.77e-04	14	52	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHB3 EPHB1	6.77e-04	14	52	2	IPR001426
Domain	EPH_lbd	EPHB3 EPHB1	6.77e-04	14	52	2	SM00615
Domain	Ephrin_lbd	EPHB3 EPHB1	6.77e-04	14	52	2	PF01404
Domain	TIL_dom	ZAN LRP2	6.77e-04	14	52	2	IPR002919
Domain	EphA2_TM	EPHB3 EPHB1	6.77e-04	14	52	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHB3 EPHB1	6.77e-04	14	52	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHB3 EPHB1	6.77e-04	14	52	2	IPR001090
Domain	EPH_LBD	EPHB3 EPHB1	6.77e-04	14	52	2	PS51550
Domain	Leu-rich_rpt	SLIT2 PXDN KERA TLR9 NLRP3	9.23e-04	271	52	5	IPR001611
Domain	Growth_fac_rcpt_	EPHB3 LRP2 LAMC3 EPHB1	9.28e-04	156	52	4	IPR009030
Domain	DSRM	DROSHA DICER1	1.26e-03	19	52	2	SM00358
Domain	LRR_8	SLIT2 PXDN KERA TLR9	1.30e-03	171	52	4	PF13855
Domain	Znf_C3HC4_RING-type	RNF112 RNF44 RNF38 RNF111	1.33e-03	172	52	4	IPR018957
Domain	dsrm	DROSHA DICER1	1.40e-03	20	52	2	PF00035
Domain	Leu-rich_rpt_typical-subtyp	SLIT2 PXDN KERA TLR9	1.48e-03	177	52	4	IPR003591
Domain	LRR_TYP	SLIT2 PXDN KERA TLR9	1.48e-03	177	52	4	SM00369
Domain	DS_RBD	DROSHA DICER1	1.54e-03	21	52	2	PS50137
Domain	-	SLIT2 PXDN KERA TLR9 NLRP3	1.95e-03	321	52	5	3.80.10.10
Domain	L_dom-like	SLIT2 PXDN KERA TLR9 NLRP3	2.14e-03	328	52	5	IPR032675
Domain	Ephrin_rec_like	EPHB3 EPHB1	2.19e-03	25	52	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB3 EPHB1	2.19e-03	25	52	2	IPR011641
Domain	LRR	SLIT2 PXDN KERA TLR9	2.35e-03	201	52	4	PS51450
Domain	EGF_Ca-bd_CS	SLIT2 FBLN7 LRP2	2.50e-03	97	52	3	IPR018097
Domain	-	DROSHA DICER1	2.55e-03	27	52	2	3.30.160.20
Domain	LRRNT	SLIT2 PXDN KERA	2.57e-03	98	52	3	IPR000372
Domain	LRRNT	SLIT2 PXDN KERA	2.57e-03	98	52	3	SM00013
Domain	EGF_CA	SLIT2 FBLN7 LRP2	2.64e-03	99	52	3	PS01187
Domain	ASX_HYDROXYL	SLIT2 FBLN7 LRP2	2.72e-03	100	52	3	PS00010
Domain	dsRBD_dom	DROSHA DICER1	2.74e-03	28	52	2	IPR014720
Domain	LRR_1	SLIT2 PXDN KERA TLR9	3.21e-03	219	52	4	PF00560
Domain	EGF-type_Asp/Asn_hydroxyl_site	SLIT2 FBLN7 LRP2	3.21e-03	106	52	3	IPR000152
Domain	zf-C3HC4	RNF112 RNF44 RNF38 RNF111	3.42e-03	223	52	4	PF00097
Domain	VWFC_1	PXDN ZAN	4.51e-03	36	52	2	PS01208
Domain	EGF_CA	SLIT2 FBLN7 LRP2	4.76e-03	122	52	3	SM00179
Domain	EGF-like_Ca-bd_dom	SLIT2 FBLN7 LRP2	4.98e-03	124	52	3	IPR001881
Domain	VWC	PXDN ZAN	5.01e-03	38	52	2	SM00214
Domain	VWFC_2	PXDN ZAN	5.01e-03	38	52	2	PS50184
Pathway	WP_EXRNA_MECHANISM_OF_ACTION_AND_BIOGENESIS	DROSHA DICER1	9.99e-05	6	37	2	M39578
Pathway	WP_MIRNA_BIOGENESIS	DROSHA DICER1	9.99e-05	6	37	2	M39416
Pubmed	Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling.	NPIPA5 NPIPA1 NPIPA3 NPIPA2	4.80e-12	4	53	4	18055785
Pubmed	Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism.	EPHB3 SLIT2 EPHB1	5.47e-07	11	53	3	19515977
Pubmed	Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development.	DROSHA DICER1	2.28e-06	2	53	2	26718009
Pubmed	DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.	DROSHA DICER1	2.28e-06	2	53	2	26906421
Pubmed	Impact of DICER1 and DROSHA on the Angiogenic Capacity of Human Endothelial Cells.	DROSHA DICER1	2.28e-06	2	53	2	34576018
Pubmed	Knock-down of core proteins regulating microRNA biogenesis has no effect on sensitivity of lung cancer cells to ionizing radiation.	DROSHA DICER1	2.28e-06	2	53	2	22479364
Pubmed	Upregulation of microRNA processing enzymes Drosha and Dicer in gestational diabetes mellitus.	DROSHA DICER1	2.28e-06	2	53	2	25295740
Pubmed	Evaluating the Effect of 3'-UTR Variants in DICER1 and DROSHA on Their Tissue-Specific Expression by miRNA Target Prediction.	DROSHA DICER1	2.28e-06	2	53	2	34287278
Pubmed	Differences in the Drosha and Dicer Cleavage Profiles in Colorectal Cancer and Normal Colon Tissue Samples.	DROSHA DICER1	2.28e-06	2	53	2	32894467
Pubmed	The effects of DICER1 and DROSHA polymorphisms on susceptibility to recurrent spontaneous abortion.	DROSHA DICER1	2.28e-06	2	53	2	31659796
Pubmed	Dicer, Drosha, and outcomes in patients with ovarian cancer.	DROSHA DICER1	2.28e-06	2	53	2	19092150
Pubmed	Dysregulated expression of dicer and drosha in breast cancer.	DROSHA DICER1	2.28e-06	2	53	2	21898071
Pubmed	Positive selection of a gene family during the emergence of humans and African apes.	NPIPA1 NPIPA8	2.28e-06	2	53	2	11586358
Pubmed	The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer.	DROSHA DICER1	2.28e-06	2	53	2	24725360
Pubmed	Expression of DROSHA and DICER genes in peripheral blood leukocytes in lung sarcoidosis.	DROSHA DICER1	2.28e-06	2	53	2	30701851
Pubmed	siRNA release from pri-miRNA scaffolds is controlled by the sequence and structure of RNA.	DROSHA DICER1	2.28e-06	2	53	2	26921501
Pubmed	Alternative initiation and splicing in dicer gene expression in human breast cells.	DROSHA DICER1	2.28e-06	2	53	2	15987463
Pubmed	Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus.	DROSHA DICER1	2.28e-06	2	53	2	18434510
Pubmed	Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins.	DROSHA DICER1	2.28e-06	2	53	2	28448850
Pubmed	Dicer and Drosha expression and response to Bevacizumab-based therapy in advanced colorectal cancer patients.	DROSHA DICER1	2.28e-06	2	53	2	23266047
Pubmed	Dicer regulates activation of the NLRP3 inflammasome.	DICER1 NLRP3	2.28e-06	2	53	2	31013297
Pubmed	DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification.	DROSHA DICER1	2.28e-06	2	53	2	23349018
Pubmed	Sequence features of Drosha and Dicer cleavage sites affect the complexity of isomiRs.	DROSHA DICER1	2.28e-06	2	53	2	25867481
Pubmed	TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis.	TLR9 NLRP3	2.28e-06	2	53	2	21439959
Pubmed	Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.	DROSHA DICER1	2.28e-06	2	53	2	25190313
Pubmed	DICER and DROSHA gene expression and polymorphisms in autoimmune thyroid diseases.	DROSHA DICER1	2.28e-06	2	53	2	27808570
Pubmed	Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer.	DROSHA DICER1	2.28e-06	2	53	2	20210522
Pubmed	Murine follicular development requires oocyte DICER, but not DROSHA.	DROSHA DICER1	2.28e-06	2	53	2	24990804
Pubmed	DROSHA rs10719 and DICER1 rs3742330 polymorphisms in endometriosis and different diseases: Case-control and review studies.	DROSHA DICER1	2.28e-06	2	53	2	33535080
Pubmed	The 3' UTR polymorphisms rs3742330 in DICER1 and rs10719 in DROSHA genes are not associated with primary open-angle and angle-closure glaucoma: As case-control study.	DROSHA DICER1	2.28e-06	2	53	2	37099569
Pubmed	The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy.	DROSHA DICER1	2.28e-06	2	53	2	21544061
Pubmed	Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer.	DROSHA DICER1	2.28e-06	2	53	2	21559780
Pubmed	Dynamic microRNA gene transcription and processing during T cell development.	DROSHA DICER1	2.28e-06	2	53	2	22379031
Pubmed	High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer.	DROSHA DICER1	2.28e-06	2	53	2	26156018
Pubmed	A role for Dicer in immune regulation.	DROSHA DICER1	2.28e-06	2	53	2	17060477
Pubmed	Association of rs1057035polymorphism in microRNA biogenesis pathway gene (DICER1) with azoospermia among Iranian population.	DROSHA DICER1	2.28e-06	2	53	2	29892896
Pubmed	Genetic variants in microRNA biogenesis pathway genes are associated with semen quality in a Han-Chinese population.	DROSHA DICER1	2.28e-06	2	53	2	22381205
Pubmed	microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma.	DROSHA DICER1	2.28e-06	2	53	2	20805302
Pubmed	The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma.	DROSHA DICER1	2.28e-06	2	53	2	21953080
Pubmed	The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord.	EPHB3 SLIT2 EPHB1	2.68e-06	18	53	3	16854408
Pubmed	Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients.	DROSHA DICER1	6.83e-06	3	53	2	25439752
Pubmed	MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production.	DROSHA DICER1	6.83e-06	3	53	2	24938790
Pubmed	EIF2C, Dicer, and Drosha are up-regulated along tumor progression and associated with poor prognosis in bladder carcinoma.	DROSHA DICER1	6.83e-06	3	53	2	25656609
Pubmed	Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs.	DROSHA DICER1	6.83e-06	3	53	2	22706270
Pubmed	Association between Genetic Polymorphisms in microRNA Machinery Genes and Risk of Papillary Thyroid Carcinoma.	DROSHA DICER1	6.83e-06	3	53	2	31250375
Pubmed	Genetic variants in microRNA machinery genes are associated [corrected] with idiopathic recurrent pregnancy loss risk.	DROSHA DICER1	6.83e-06	3	53	2	24769857
Pubmed	Immunohistochemical analysis of the endoribonucleases Drosha, Dicer and Ago2 in smooth muscle tumours of soft tissues.	DROSHA DICER1	6.83e-06	3	53	2	22394132
Pubmed	The RNase III enzyme DROSHA is essential for microRNA production and spermatogenesis.	DROSHA DICER1	6.83e-06	3	53	2	22665486
Pubmed	A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.	EPHB3 EPHB1	6.83e-06	3	53	2	23143520
Pubmed	Toll-Like Receptor 9 Is Involved in NLRP3 Inflammasome Activation and IL-1β Production Through Monosodium Urate-Induced Mitochondrial DNA.	TLR9 NLRP3	6.83e-06	3	53	2	32700178
Pubmed	Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.	DROSHA DICER1	6.83e-06	3	53	2	26976605
Pubmed	The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells.	DROSHA DICER1	6.83e-06	3	53	2	30295958
Pubmed	Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.	DROSHA DICER1	6.83e-06	3	53	2	26437240
Pubmed	Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin.	DROSHA DICER1	6.83e-06	3	53	2	22434867
Pubmed	The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses.	TLR9 NLRP3	6.83e-06	3	53	2	22777876
Pubmed	Complexity in regulation of microRNA machinery components in invasive breast carcinoma.	DROSHA DICER1	6.83e-06	3	53	2	24574065
Pubmed	Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients.	DROSHA DICER1	6.83e-06	3	53	2	22371183
Pubmed	Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas.	DROSHA DICER1	6.83e-06	3	53	2	26227789
Pubmed	Pineoblastoma is uniquely tolerant of mutually exclusive loss of DICER1, DROSHA or DGCR8.	DROSHA DICER1	6.83e-06	3	53	2	32124011
Pubmed	Canonical and alternate functions of the microRNA biogenesis machinery.	DROSHA DICER1	6.83e-06	3	53	2	20713509
Pubmed	Investigation of AID, Dicer, and Drosha Expressions in Patients with Chronic Lymphocytic Leukemia.	DROSHA DICER1	6.83e-06	3	53	2	28388279
Pubmed	Drosha, DGCR8, and Dicer mRNAs are down-regulated in human cells infected with dengue virus 4, and play a role in viral pathogenesis.	DROSHA DICER1	6.83e-06	3	53	2	27173348
Pubmed	EphB receptors couple dendritic filopodia motility to synapse formation.	EPHB3 EPHB1	6.83e-06	3	53	2	18614029
Pubmed	Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder.	DROSHA DICER1	6.83e-06	3	53	2	22766726
Pubmed	Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase.	EPHB3 EPHB1	6.83e-06	3	53	2	29731254
Pubmed	Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.	EPHB3 EPHB1	6.83e-06	3	53	2	35025117
Pubmed	The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.	DROSHA DICER1	6.83e-06	3	53	2	34855193
Pubmed	Male germ cells express abundant endogenous siRNAs.	DROSHA DICER1	6.83e-06	3	53	2	21788498
Pubmed	Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas.	DROSHA DICER1	6.83e-06	3	53	2	21769619
Pubmed	Multiple EphB receptors mediate dorsal-ventral retinotopic mapping via similar bi-functional responses to ephrin-B1.	EPHB3 EPHB1	6.83e-06	3	53	2	25051176
Pubmed	Transcript Level of MicroRNA Processing Elements in Gastric Cancer.	DROSHA DICER1	6.83e-06	3	53	2	30168106
Pubmed	Expression of genes for microRNA-processing enzymes is altered in advanced non-alcoholic fatty liver disease.	DROSHA DICER1	6.83e-06	3	53	2	23663110
Pubmed	A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition.	EPHB3 EPHB1	6.83e-06	3	53	2	22622783
Pubmed	Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues.	EPHB3 EPHB1	6.83e-06	3	53	2	11532925
Pubmed	Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus.	EPHB3 EPHB1	6.83e-06	3	53	2	14691139
Pubmed	Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling.	EPHB3 SLIT2 EPHB1	8.47e-06	26	53	3	35927240
Pubmed	Dicer and Drosha expression in patients with nephrotic syndrome.	DROSHA DICER1	1.36e-05	4	53	2	32412691
Pubmed	Argonaute, Dicer, and Drosha are up-regulated along tumor progression in serous ovarian carcinoma.	DROSHA DICER1	1.36e-05	4	53	2	22647351
Pubmed	Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.	DROSHA DICER1	1.36e-05	4	53	2	20699384
Pubmed	EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak.	EPHB3 EPHB1	1.36e-05	4	53	2	23147113
Pubmed	TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection.	TLR9 NLRP3	1.36e-05	4	53	2	32290861
Pubmed	Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2.	DROSHA DICER1	1.36e-05	4	53	2	22198669
Pubmed	Eph receptor deficiencies lead to altered cochlear function.	EPHB3 EPHB1	1.36e-05	4	53	2	12684184
Pubmed	Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors.	EPHB3 EPHB1	1.36e-05	4	53	2	22475621
Pubmed	3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.	DROSHA DICER1	1.36e-05	4	53	2	26147304
Pubmed	Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB.	DROSHA DICER1	1.36e-05	4	53	2	27545503
Pubmed	Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling.	EPHB3 EPHB1	1.36e-05	4	53	2	21804545
Pubmed	Analysis of microRNA processing machinery gene (DROSHA, DICER1, RAN, and XPO5) variants association with end-stage renal disease.	DROSHA DICER1	1.36e-05	4	53	2	32770606
Pubmed	GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking.	EPHB3 EPHB1	1.36e-05	4	53	2	15965473
Pubmed	The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response.	TLR9 NLRP3	2.27e-05	5	53	2	18288107
Pubmed	Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell.	TLR9 NLRP3	2.27e-05	5	53	2	27045344
Pubmed	miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.	DROSHA DICER1	2.27e-05	5	53	2	27880903
Pubmed	TLR9 Regulates the NF-κB-NLRP3-IL-1β Pathway Negatively in Salmonella-Induced NKG2D-Mediated Intestinal Inflammation.	TLR9 NLRP3	2.27e-05	5	53	2	28576980
Pubmed	Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping.	EPHB3 EPHB1	2.27e-05	5	53	2	21847105
Pubmed	The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.	DROSHA DICER1	2.27e-05	5	53	2	18725527
Pubmed	Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex.	EPHB3 EPHB1	2.27e-05	5	53	2	21559471
Pubmed	BRG1 and SMARCAL1 transcriptionally co-regulate DROSHA, DGCR8 and DICER in response to doxorubicin-induced DNA damage.	DROSHA DICER1	2.27e-05	5	53	2	28716689
Pubmed	Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.	TLR9 NLRP3	3.40e-05	6	53	2	19164858
Pubmed	Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord.	EPHB3 EPHB1	3.40e-05	6	53	2	16786562
Pubmed	Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning.	EPHB3 EPHB1	3.40e-05	6	53	2	19182796
Cytoband	16p13.11	NPIPA5 NPIPA1 NPIPA3 NPIPA2	1.38e-08	23	53	4	16p13.11
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	PIGQ NPIPA5 NPIPA1 NPIPA3 NPIPA7 NPIPA2	9.79e-06	426	53	6	chr16p13
Cytoband	15q21.3	PIGB PIERCE2	7.59e-04	35	53	2	15q21.3
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB3 EPHB1	2.73e-04	14	32	2	1095
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGQ PIGB	6.24e-04	21	32	2	680
GeneFamily	Ring finger proteins	RNF112 RNF44 RNF38 RNF111	1.35e-03	275	32	4	58
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLIT2 BMP6 DPPA4 NPIPA5 LAMC3 ALX4	5.46e-08	171	53	6	a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCell	BAL-Control-Lymphocyte-T/NK-Other_T\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TYMS KIF18A FBLN7 STIL NPIPA8	2.02e-06	174	53	5	94575a605c725de83f66a6cf7df9d7bb360ffc56
ToppCell	BAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TYMS KIF18A FBLN7 STIL NPIPA8	2.02e-06	174	53	5	40c81ab36d7931e271e20d7d56fed32463c75f41
ToppCell	BAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TYMS KIF18A FBLN7 STIL NPIPA8	2.02e-06	174	53	5	b43fb0fbb492c1be6e791a1c4d6c4e5956955ee4
ToppCell	Influenza_Severe-Plasmablast\|Influenza_Severe / Disease group and Cell class	TYMS KIF18A SORBS2 KDF1 NPIPA2	2.07e-06	175	53	5	3f9b9793d3d1b7a9b97899272b6a0d37b05c11d1
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPHB3 TYMS LAMC3 KDF1	3.14e-05	151	53	4	c06a54afe918b14f885d6a85fbcf81e80f33afae
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FBLN7 BMP6 LAMC3 ALX4	3.39e-05	154	53	4	65dbb60f636562eeba3dafadae9c0c7db2b27476
ToppCell	LPS-antiTNF-Endothelial-Endothelial-FOXM1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TYMS KIF18A BMP6 STIL	4.23e-05	163	53	4	5285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FBLN7 BMP6 LAMC3 ALX4	4.44e-05	165	53	4	570483b43ccb5831feec9337b4664814431d40b1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FBLN7 BMP6 LAMC3 ALX4	4.44e-05	165	53	4	2026a9a07f4d314cc05c167e491312b373468e46
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FBLN7 BMP6 LAMC3 ALX4	4.76e-05	168	53	4	26aa96b2b547d11941cb803995ea3d302ee0518c
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TYMS C19orf81 KIF18A STIL	4.87e-05	169	53	4	a34aff9257ae9746226ee7af595c4678a4b0c896
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS SORBS2 RNF112 EPHB1	4.99e-05	170	53	4	35e3945d8a540a3e2cec1b559316265aaad023d1
ToppCell	PND01-Endothelial-Endothelial_lymphatic\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS SORBS2 RNF112 EPHB1	4.99e-05	170	53	4	0ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS SORBS2 RNF112 EPHB1	4.99e-05	170	53	4	0b5ddc7d452db0a389927a367914f7d257703f7e
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FBLN7 BMP6 LAMC3 ALX4	5.10e-05	171	53	4	2e43fb129ee9bdc3b31febc43c10f959bf0f4a7d
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FBLN7 BMP6 LAMC3 ALX4	5.10e-05	171	53	4	e219a1aa59a96e4bc3e2eacf985679174a51de41
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	TYMS KIF18A DPPA4 STIL	5.22e-05	172	53	4	8d20eda599abf1e9e3e3b90f314acddee6a465a4
ToppCell	URO-Lymphocyte-B-Plasmablast\|URO / Disease, Lineage and Cell Type	TYMS KIF18A NPIPA1 STIL	5.22e-05	172	53	4	48888ef50ac784b38aca81da68f8a94ce09c670d
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Reln_(Neuron.Gad1Gad2.Cplx3-Reln)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ZAN LRP2 KDF1	5.29e-05	61	53	3	06aab3f1743ced1e46d22f0310f1cdb70c7a108e
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Reln_(Neuron.Gad1Gad2.Cplx3-Reln)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ZAN LRP2 KDF1	5.29e-05	61	53	3	fec6c9a4e12c260338856567bf547f914f473dbb
ToppCell	BAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EPHB3 TYMS STIL NPIPA8	5.58e-05	175	53	4	553e68e8b439a2293efb969e1e2aa017ceb80daf
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TYMS SORBS2 STIL NPIPA2	5.58e-05	175	53	4	89bf89466191da14896ed8928027f5b911436c22
ToppCell	BAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	EPHB3 TYMS STIL NPIPA8	5.58e-05	175	53	4	16d4e97271df1db9a0d167fc82a90d84d20dd1f2
ToppCell	BAL-Control-Lymphocyte-T/NK-Other_T\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	EPHB3 TYMS STIL NPIPA8	5.58e-05	175	53	4	289d2aa7164bc02b1876b99f2fb67baa8e030c4e
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-plasmablast-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TYMS BMP6 SORBS2 NPIPA2	5.83e-05	177	53	4	d2c1f46913ac00bbc0bb9320d5652edc01b34179
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-plasmablast\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TYMS BMP6 SORBS2 NPIPA2	5.83e-05	177	53	4	65e090aad0ffb737ce034e25bd5b12a0b1dd9684
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	FBLN7 ZNF469 PXDN NLRP3	6.09e-05	179	53	4	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	LPS-IL1RA-Endothelial-Endothelial-FOXM1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TYMS KIF18A BMP6 STIL	6.23e-05	180	53	4	334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	C19orf81 NPIPA5 NPIPA2 EPHB1	6.23e-05	180	53	4	e4add4c94f892a2d93926e5c6dac6a738319d091
ToppCell	Severe-Lymphoid-pDC\|Severe / Condition, Lineage, Cell class and cell subclass	C19orf81 ZAN DPPA4 TLR9	6.36e-05	181	53	4	2caecb7c5dcdad46fd02b4ffb73cb613ce835187
ToppCell	3'_v3-Lung-Myeloid_Dendritic-pDC\|Lung / Manually curated celltypes from each tissue	ZAN DPPA4 TLR9 EPHB1	6.36e-05	181	53	4	3d7f089fb434fbc989f1fa159e22133ae00b2487
ToppCell	Severe-Lymphoid-pDC-\|Severe / Condition, Lineage, Cell class and cell subclass	C19orf81 ZAN DPPA4 TLR9	6.36e-05	181	53	4	277ce4c49121da0990a5933b19d2c6af9bbe253e
ToppCell	Control-T/NK-proliferating_T/NK\|Control / Disease group,lineage and cell class （2021.01.30）	EPHB3 TYMS STIL NPIPA8	6.64e-05	183	53	4	e740f05536d1e4b2512811771928eb65f6696409
ToppCell	Control-T/NK_proliferative\|Control / Disease group and Cell class	TYMS KIF18A STIL NPIPA8	6.64e-05	183	53	4	09c2b4e630f1c338f02c1242e3598e870d6b0a28
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RNF112 LRP2 NRG2 TAPBP	6.64e-05	183	53	4	274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCell	URO-Myeloid-pDC\|URO / Disease, Lineage and Cell Type	C19orf81 DPPA4 TLR9 EPHB1	6.78e-05	184	53	4	0edb5dd003c2bca0b9e3ec18d03610d68bd52538
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZAN DPPA4 TLR9 EPHB1	7.07e-05	186	53	4	0096a61b1841784c913752b4f3639200446cc02c
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZAN DPPA4 TLR9 EPHB1	7.07e-05	186	53	4	6345777847960c71a2ba3ce5a49c72c34ebd0e73
ToppCell	cellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ZAN DPPA4 TLR9 EPHB1	7.07e-05	186	53	4	d23c3318937492d7d665bec14253124c49181b5a
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZAN DPPA4 TLR9 EPHB1	7.07e-05	186	53	4	9e159ad7289dcae2ec7ce655df746f46801b81d3
ToppCell	BAL-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	C19orf81 DPPA4 TLR9 EPHB1	7.83e-05	191	53	4	989bf108c7f2c78dd7f14481570f1819673a5469
ToppCell	BAL-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	C19orf81 DPPA4 TLR9 EPHB1	7.83e-05	191	53	4	3e7fbe4af2c23b3b964becde843d2f088ad41c23
ToppCell	BAL-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	C19orf81 DPPA4 TLR9 EPHB1	7.83e-05	191	53	4	bc2f3c4e71e3a55fe76ea03f45746329a8fc81da
ToppCell	COVID-19-Lymphoid-pDC\|COVID-19 / Condition, Lineage and Cell class	C19orf81 DPPA4 TLR9 EPHB1	7.83e-05	191	53	4	25343b11d42128ad16659e5519cd1673266cc505
ToppCell	BAL-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	C19orf81 DPPA4 TLR9 EPHB1	7.99e-05	192	53	4	d9ff2293358c8b031ba212021012e058014ff472
ToppCell	Severe_COVID-19-Myeloid-pDC\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	C19orf81 DPPA4 TLR9 EPHB1	7.99e-05	192	53	4	f79424c643a375dfe4579eff7ac1ba191e28a283
ToppCell	BAL-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	C19orf81 DPPA4 TLR9 EPHB1	7.99e-05	192	53	4	2e8611d65090e39f1a6e74c972288e7b68376d15
ToppCell	BAL-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	C19orf81 DPPA4 TLR9 EPHB1	7.99e-05	192	53	4	43569726df281eebe57499e0993b9fd9d36118c2
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZAN DPPA4 TLR9 EPHB1	8.32e-05	194	53	4	bb36274d6fe2d18c545a17d3809f331586502d01
ToppCell	medial-2-Hematologic-Plasmacytoid_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZAN DPPA4 TLR9 EPHB1	8.32e-05	194	53	4	d58be6454a0795d6771036a1620553a153861615
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZAN DPPA4 TLR9 EPHB1	8.32e-05	194	53	4	0117cd68750153fd6b8978c8b4ce3589486d2b5f
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ZAN DPPA4 TLR9 EPHB1	8.49e-05	195	53	4	fbc324c3435f32b9ca269d83333faecfe940d7fe
ToppCell	COVID-19-lung-Proliferative_fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	TYMS SLIT2 KIF18A STIL	8.65e-05	196	53	4	2ce8a787f2731faa913d20342d73041d59468f27
ToppCell	COVID-19-lung-Proliferative_fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TYMS SLIT2 KIF18A STIL	8.65e-05	196	53	4	ca91d5e325875e7444809b80fcbd491d8899ea36
ToppCell	5'-Airway_Nasal-Immune_Myeloid\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZNF469 TLR9 NLRP3 EPHB1	8.65e-05	196	53	4	9c942bf9fc78caa173d2c7de5fe4c17f076c623b
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TYMS KIF18A FBLN7 STIL	8.83e-05	197	53	4	84ed777cdba569200a3ef1654d8a12f17fcfb7f1
ToppCell	Influenza-Influenza_Severe-Lymphocyte-B-Plasmablast\|Influenza_Severe / Disease, condition lineage and cell class	TYMS KIF18A SORBS2 THNSL1	8.83e-05	197	53	4	9108edafbf5744ed65f556bcbbf819a9b71176a9
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TYMS KIF18A FBLN7 STIL	8.83e-05	197	53	4	8b616cde333bdbc0c591035ad9e4949155866245
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Proliferating-Cycling_Progenitors\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	TYMS KIF18A FBLN7 STIL	9.18e-05	199	53	4	a99516a5760f49a69b0fe45a9b2316e393252966
ToppCell	TCGA-Cervix-Primary_Tumor\|TCGA-Cervix / Sample_Type by Project: Shred V9	TYMS KIF18A STIL KDF1	9.18e-05	199	53	4	ef6fde26af2ca9e6cde198ac0e14e03d9ab398f8
ToppCell	Sepsis-URO-Lymphocyte-B-Plasmablast\|URO / Disease, condition lineage and cell class	TYMS KIF18A NPIPA1 STIL	9.18e-05	199	53	4	0df6cafb7f3b607cbe80b6f25b4fd62d421d01ee
ToppCell	facs-Skin-Anagen-24m-Epithelial-inner_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C19orf81 ZNF668 HERC2	2.30e-04	100	53	3	97ca9cda55a05fbb4d1f5d61f847c965e014f05c
ToppCell	COVID-19_Mild-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	NPIPA5 NPIPA2 NPIPA8	4.33e-04	124	53	3	5ef9eb806fb2c8ee5aae0a75503d244b08ee10d4
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Neuronal-Interneuron\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	SLIT2 PIGB RNF38	4.43e-04	125	53	3	eafc39072467e209c9fe3a4fa41cb09507a42e82
ToppCell	TCGA-Testes\|World / Sample_Type by Project: Shred V9	ZAN DPPA4 GJA10	4.75e-04	128	53	3	a09b0e221b8749510002304e4d34d6a2eb8867e9
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FBLN7 BMP6 ALX4	5.19e-04	132	53	3	560e836764ed7806fb18282dfebe434d30112a9a
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	BMP6 KERA LAMC3	5.19e-04	132	53	3	893b7ec2a2d8a140cc98575d1beca1189f053e9a
ToppCell	PBMC-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	PIGQ ZNF469 ZNF785	5.31e-04	133	53	3	e53fbd69775a4bff61de82557342f7ac80915c4d
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells-neuroepithelial-like_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	FBLN7 DPPA4 RPL18A	5.31e-04	133	53	3	bdaba11e8d9868eca57c3c976e381ee096d39ddf
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FBLN7 BMP6 ALX4	5.55e-04	135	53	3	7e3559ed0fef7916d1938b4e1a9fa4456a60e3d3
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Agt_(Agt)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FBLN7 BMP6 ALX4	5.55e-04	135	53	3	4cb399620aa9edc2ca59e4df76ab7011ceb58db9
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FBLN7 BMP6 ALX4	5.55e-04	135	53	3	6bd2a0bfd8d20950f1b66810668682dc055a0ada
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Agt_(Agt)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FBLN7 BMP6 ALX4	5.55e-04	135	53	3	97989546826bf3739e1b86a10832a457fd37c5d2
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	C19orf81 PXDN DPPA4	5.79e-04	137	53	3	6d90da42dcc06aa895f920218055068f3c76d57d
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF668 LRP2 KDF1	5.91e-04	138	53	3	5f8ac8f67e34a7cf560099208e6884102532391e
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	EPHB3 PXDN DPPA4	6.56e-04	143	53	3	27e06327f96cb72bd111ea6ece6307e5ebb3a146
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic-hematopoietic_progenitor\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	EPHB3 PXDN DPPA4	6.56e-04	143	53	3	4edef95ae2a1ef4fc4b0d4fadf75bfc54b583932
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	C19orf81 LAMC3 NPIPA3	6.69e-04	144	53	3	cf9f049ab6cd80521598124f057c2debdde24788
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	POLD2 RNF112 LRP2	6.69e-04	144	53	3	1b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
ToppCell	TCGA-Uterus\|World / Sample_Type by Project: Shred V9	CACNA1S KERA ALX4	6.69e-04	144	53	3	7efb45286ebf2dbfb9125fd6373f28dccb029a2e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil-Neu_c3-CST7\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KIF18A DICER1 EPHB1	6.69e-04	144	53	3	b638398f559e7fd9d4294d1c830beeb20f905960
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	C19orf81 LAMC3 NPIPA3	6.69e-04	144	53	3	41eaeca54b3c39de417597267cbdb1f195dd885a
ToppCell	Adult-Mesenchymal-chondrocyte-D122\|Adult / Lineage, Cell type, age group and donor	C19orf81 SLIT2 PIERCE2	7.24e-04	148	53	3	81a1e6fdd942a612bf523c59b8b4974f6ca1fdce
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP\|Cerebellum / BrainAtlas - Mouse McCarroll V32	BMP6 PXDN ALX4	7.39e-04	149	53	3	3980fa4f1986a2f164a1826ea043fb71f1d756cd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPIPA1 LAMC3 ALX4	7.53e-04	150	53	3	7a9d6a7ff8000e9a061e1b586e4c258cc91a2a09
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPIPA1 LAMC3 ALX4	7.53e-04	150	53	3	e5b843cb2bc847f6cab4cbec0a2a6a72fac50fee
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	BMP6 LAMC3 ALX4	7.97e-04	153	53	3	e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	BMP6 LAMC3 ALX4	7.97e-04	153	53	3	b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP\|Thalamus / BrainAtlas - Mouse McCarroll V32	BMP6 LAMC3 ALX4	7.97e-04	153	53	3	2513edfae62a44e51d3556675a096723194c966c
ToppCell	BAL-Control-cDC_12\|Control / Compartment, Disease Groups and Clusters	TYMS SLIT2 STIL	8.13e-04	154	53	3	0121d08cc527aed9b3e11ff62bb9012916f5c56b
ToppCell	10x5'-bone_marrow-Lymphocytic_B-GC_B_(I)\|bone_marrow / Manually curated celltypes from each tissue	TYMS STIL PIERCE2	8.59e-04	157	53	3	d4da4057917dda066da0f2aac2621fdaf1fb943b
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FBLN7 BMP6 LAMC3	8.91e-04	159	53	3	34c90711c5857cf6ada7b3acff99f1d48c7caf29
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	C19orf81 ZNF276 RNF112	8.91e-04	159	53	3	330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	C19orf81 ZNF276 RNF112	8.91e-04	159	53	3	cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	BMP6 LAMC3 ALX4	8.91e-04	159	53	3	92049a8d8fc9997d8d0d76500c72596a9b2394e0
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 ALX4 UNC80	9.07e-04	160	53	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 ALX4 UNC80	9.07e-04	160	53	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHB3 BMP6 NRG2	9.24e-04	161	53	3	7c9d4410d7142a5f3a05418c994f69978c9ffa17
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZAN DPPA4 UNC80	9.41e-04	162	53	3	bf886e22ff2a20353499004b53f25fb9e6574896
Disease	phosphatidylcholine 40:7 measurement	NPIPA1 NPIPA2	2.08e-04	13	49	2	EFO_0021477
Disease	hepatocellular carcinoma (is_implicated_in)	TYMS TLR9 DICER1 ALX4	2.34e-04	181	49	4	DOID:684 (is_implicated_in)
Disease	dermatomyositis (is_marker_for)	SLIT2 TLR9	3.62e-04	17	49	2	DOID:10223 (is_marker_for)
Disease	eye colour measurement	ZNF469 SORBS2 LRP2 HERC2	4.73e-04	218	49	4	EFO_0009764
Disease	hair colour measurement	ZNF469 ZNF276 PXDN NRG2 HERC2 ALX4	5.23e-04	615	49	6	EFO_0007822
Disease	phospholipid measurement, intermediate density lipoprotein measurement	NPIPA1 NPIPA2 RNF111	6.03e-04	99	49	3	EFO_0004639, EFO_0008595
Disease	Brain Diseases	TYMS LAMC3	7.91e-04	25	49	2	C0006111
Disease	Encephalopathies	TYMS LAMC3	9.23e-04	27	49	2	C0085584
Disease	non-melanoma skin carcinoma	ZNF469 ZNF276 ZAN HERC2	9.81e-04	265	49	4	EFO_0009260
Disease	Bilateral Wilms Tumor	DROSHA DICER1	1.07e-03	29	49	2	C2930471
Disease	cortical surface area measurement	PIGQ SLIT2 BMP6 ZNF469 ZAN LAMC3 ALX4 EPHB1	1.56e-03	1345	49	8	EFO_0010736
Disease	Nephroblastoma	DROSHA DICER1	1.64e-03	36	49	2	C0027708

Protein segments in the cluster

Peptide	Gene	Start	Entry
CVVPCDPVPACMSPH	ALX4	321	Q9H161
FQMHPLYKCTQPPCP	GJA10	181	Q969M2
FPPPHLEDNMLCPKC	DPPA4	276	Q7L190
AQMHLLPSPPEPRLC	DNHD1	4381	Q96M86
CLKIPPRCMFDHPDA	DICER1	1641	Q9UPY3
PPECVCSLPFHPQRM	NPIPA1	331	Q9UND3
YRLPPPMDCPAALHQ	EPHB1	841	P54762
NPCPMDSRPCRHLPK	FBLN7	321	Q53RD9
FPTPPASQPLCLCME	C19orf81	71	C9J6K1
CRQCHLTTPIMFPPE	HERC2	1416	O95714
MTFPQLGPVQPIPCC	KIF18A	636	Q8NI77
LPQQPLHPCMFPLAT	POLD2	306	P49005
MRQVCCSALPPPPLE	NRG2	1	O14511
PPCVNPGNPVFSCML	PIERCE2	26	H3BRN8
RLPPPMDCPTALHQL	EPHB3	856	P54753
IELPINLPPPCRCMH	LRP2	4371	P98164
PPKCVCSLPFHPQRM	NPIPA3	331	F8WFD2
PKCVCSLPFHPQRMI	NPIPA2	351	E9PIF3
CTICQMPPPPHLSAL	OLIG3	241	Q7RTU3
APPAPCQCPRVESSM	CACNA1S	1736	Q13698
HLMNPEYVPKPCCAP	BMP6	466	P22004
EPPCNDPMVCRLPVS	CTSF	86	Q9UBX1
EDPCCPLHFQLPPQM	KANSL2	356	Q9H9L4
MLEPPFCPDPHAVYC	GRK4	461	P32298
PECVCSLPFHPQRMI	NPIPA7	351	E9PJI5
PECVCSLPFHPQRMI	NPIPA8	351	P0DM63
IMSCCPDPNPPIHKI	NLRP3	276	Q96P20
SHVHCPLPMRFLQCP	PIGB	446	Q92521
DSPPCCPRFHFMPRF	DROSHA	671	Q9NRR4
QHLPVCSVPPPMLQA	RNF38	236	Q9H0F5
PPECVCSLPFHPQRM	NPIPA5	331	E9PKD4
PRCPEHCPMPTLCTQ	PIGQ	656	Q9BRB3
ECPMECFCPPSFPTA	KERA	41	O60938
SCCKEPLADPPPMRH	KDF1	186	Q8NAX2
CLPTPKCHTPPLYRM	RPL18A	16	Q02543
IHCPPYQNDCGRMPR	SORBS2	796	O94875
ARPPSHMDLCNPQPC	STIL	686	Q15468
PEMPHEPLACANLPR	UNC80	606	Q8N2C7
PFPCPECGRRFMQPV	ZNF668	111	Q96K58
PQPMAPRELPTCSIC	RNF112	46	Q9ULX5
PPAMPRLPSCCPQHS	RNF111	471	Q6ZNA4
WNCPPVGLSPMHFPC	TLR9	96	Q9NR96
APNPCMECPRHFPQL	TLR9	261	Q9NR96
MFSGQHYPLCCLPPP	RNF44	141	Q7L0R7
APAPHCEMSRFVPLP	TAPBP	86	O15533
NLPPSMCDYRHEPLC	GAFA1	56	Q96PS6
CSNDPPCFSVMIPPN	PXDN	851	Q92626
PCPHPGCNKVFMIDR	ZNF276	466	Q8N554
DLPLMALPPCHALCQ	TYMS	186	P04818
QLMPHIFAHCIPPSC	THNSL1	356	Q8IYQ7
CEFSPPMVLPRTSPC	SLIT2	1111	O94813
KLAHTPAPPPTCYMC	ZNF469	3106	Q96JG9
ACPEFCNPRQSPMNP	ZNF785	146	A8K8V0
WREPHFCPMACPPNS	ZAN	1416	Q9Y493
APRPADKCMPCSCHP	LAMC3	856	Q9Y6N6