Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin binding	MKRN4P CITED2 TRIM33 ASXL1 NFKB1 PER1 ACTN4 DMRT1 MBD2 HNRNPD	3.46e-05	739	56	10	GO:0003682
GeneOntologyMolecularFunction	calcium- and calmodulin-responsive adenylate cyclase activity	ADCY5 ADCY8	7.68e-05	5	56	2	GO:0008294
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SP8 FOXD3 TEAD2 NFKB1 ZNF746 PER1 DMRT1 ZNF865 FOXF2 EVX2 TLX1	5.83e-04	1244	56	11	GO:0000978
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SP8 FOXD3 TEAD2 NFKB1 ZNF746 PER1 ACTN4 DMRT1 ZNF865 FOXF2 EVX2 TLX1	6.06e-04	1459	56	12	GO:0000977
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SP8 FOXD3 TEAD2 NFKB1 ZNF746 PER1 DMRT1 ZNF865 FOXF2 EVX2 TLX1	6.98e-04	1271	56	11	GO:0000987
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulator activity	WDR81 IRS1	1.15e-03	18	56	2	GO:0035014
GeneOntologyMolecularFunction	adenylate cyclase activity	ADCY5 ADCY8	1.15e-03	18	56	2	GO:0004016
GeneOntologyBiologicalProcess	circadian regulation of translation	PER1 HNRNPD	4.33e-05	4	56	2	GO:0097167
GeneOntologyBiologicalProcess	peroxisome proliferator activated receptor signaling pathway	CITED2 ASXL1 ACTN4	5.92e-05	28	56	3	GO:0035357
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	CITED2 ASXL1 FOXD3 TEAD2 RPS6KA5 NFKB1 ZNF746 PER1 ACTN4 DMRT1 HNRNPD FOXF2 TLX1	6.89e-05	1390	56	13	GO:0045944
GeneOntologyCellularComponent	chromatin	CITED2 TRIM33 SP8 FOXD3 TEAD2 NFKB1 HLX DMRT1 MBD2 HNRNPD FOXF2 EVX2 TLX1	9.34e-05	1480	55	13	GO:0000785
Domain	Adcy_conserved_dom	ADCY5 ADCY8	1.31e-04	6	56	2	IPR009398
Domain	DUF1053	ADCY5 ADCY8	1.31e-04	6	56	2	PF06327
Domain	ANION_EXCHANGER_2	SLC4A5 SLC4A2	1.84e-04	7	56	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A5 SLC4A2	1.84e-04	7	56	2	PS00219
Domain	AC_N	ADCY5 ADCY8	2.44e-04	8	56	2	IPR032628
Domain	Adcy	ADCY5 ADCY8	2.44e-04	8	56	2	IPR030672
Domain	AC_N	ADCY5 ADCY8	2.44e-04	8	56	2	PF16214
Domain	Band3_cytoplasmic_dom	SLC4A5 SLC4A2	3.14e-04	9	56	2	IPR013769
Domain	Band_3_cyto	SLC4A5 SLC4A2	3.14e-04	9	56	2	PF07565
Domain	-	SLC4A5 SLC4A2	3.14e-04	9	56	2	3.40.1100.10
Domain	HCO3_cotransp	SLC4A5 SLC4A2	3.91e-04	10	56	2	PF00955
Domain	HCO3_transpt_C	SLC4A5 SLC4A2	3.91e-04	10	56	2	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A5 SLC4A2	3.91e-04	10	56	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A5 SLC4A2	3.91e-04	10	56	2	IPR003020
Domain	A/G_cyclase_CS	ADCY5 ADCY8	1.17e-03	17	56	2	IPR018297
Domain	Nucleotide_cyclase	ADCY5 ADCY8	1.31e-03	18	56	2	IPR029787
Domain	-	ADCY5 ADCY8	1.31e-03	18	56	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	ADCY5 ADCY8	1.46e-03	19	56	2	PS00452
Domain	Guanylate_cyc	ADCY5 ADCY8	1.46e-03	19	56	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY5 ADCY8	1.46e-03	19	56	2	PS50125
Domain	A/G_cyclase	ADCY5 ADCY8	1.46e-03	19	56	2	IPR001054
Domain	CYCc	ADCY5 ADCY8	1.46e-03	19	56	2	SM00044
Domain	Homeobox_metazoa	HLX EVX2 TLX1	2.49e-03	90	56	3	IPR020479
Domain	Ank_2	SHANK1 KANK3 NFKB1 ANKRD24	3.93e-03	215	56	4	PF12796
Domain	Ank	SHANK1 KANK3 NFKB1 ANKRD24	4.84e-03	228	56	4	PF00023
Domain	-	SHANK1 KANK3 NFKB1 ANKRD24	6.49e-03	248	56	4	1.25.40.20
Domain	ANK	SHANK1 KANK3 NFKB1 ANKRD24	6.77e-03	251	56	4	SM00248
Domain	ANK_REPEAT	SHANK1 KANK3 NFKB1 ANKRD24	6.96e-03	253	56	4	PS50088
Domain	Ankyrin_rpt-contain_dom	SHANK1 KANK3 NFKB1 ANKRD24	7.05e-03	254	56	4	IPR020683
Domain	ANK_REP_REGION	SHANK1 KANK3 NFKB1 ANKRD24	7.05e-03	254	56	4	PS50297
Domain	Keratin_I	KRT9 KRT12	7.71e-03	44	56	2	IPR002957
Domain	Ankyrin_rpt	SHANK1 KANK3 NFKB1 ANKRD24	7.85e-03	262	56	4	IPR002110
Domain	TF_fork_head_CS_2	FOXD3 FOXF2	8.40e-03	46	56	2	IPR030456
Domain	TF_fork_head_CS_1	FOXD3 FOXF2	8.75e-03	47	56	2	IPR018122
Domain	ZnF_C3H1	MKRN4P ZC3H10	9.12e-03	48	56	2	SM00356
Domain	zf-CCCH	MKRN4P ZC3H10	9.49e-03	49	56	2	PF00642
Domain	FH	FOXD3 FOXF2	9.49e-03	49	56	2	SM00339
Domain	FORK_HEAD_1	FOXD3 FOXF2	9.49e-03	49	56	2	PS00657
Domain	FORK_HEAD_2	FOXD3 FOXF2	9.49e-03	49	56	2	PS00658
Domain	Fork_head_dom	FOXD3 FOXF2	9.49e-03	49	56	2	IPR001766
Domain	FORK_HEAD_3	FOXD3 FOXF2	9.49e-03	49	56	2	PS50039
Domain	Forkhead	FOXD3 FOXF2	9.49e-03	49	56	2	PF00250
Domain	-	HLX TERF2 EVX2 TLX1	1.02e-02	283	56	4	1.10.10.60
Pathway	PID_LPA4_PATHWAY	RPS6KA5 ADCY5 ADCY8	1.09e-05	15	42	3	M56
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	TRIM33 FOXD3 NFKB1 RTN4R IRS1 MBD2 TERF2	2.68e-05	301	42	7	MM15983
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A5 SLC4A2	3.84e-04	10	42	2	M27335
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY5 ADCY8	3.84e-04	10	42	2	M19522
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A5 SLC4A2	3.84e-04	10	42	2	MM15073
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY5 ADCY8	3.84e-04	10	42	2	MM14668
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT9 KRT12 PCSK6 SPINK5	5.72e-04	129	42	4	M27649
Pathway	REACTOME_SIGNALING_BY_NTRKS	RPS6KA5 PCSK6 DUSP7 IRS1	6.60e-04	134	42	4	M3574
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	TRIM33 FOXD3 TEAD2 KRT9 KRT12 ABL2 RPS6KA5 NFKB1 PCSK6 CACNA1I DMRT1 SPINK5	7.03e-04	1432	42	12	M509
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	RPS6KA5 NFKB1 DUSP7	7.12e-04	59	42	3	MM15128
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY5 ADCY8	7.71e-04	14	42	2	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY5 ADCY8	7.71e-04	14	42	2	M750
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY5 ADCY8	8.88e-04	15	42	2	M47794
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_NFKB_SIGNALING_PATHWAY	ABL2 NFKB1	8.88e-04	15	42	2	M47816
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY5 ADCY8	8.88e-04	15	42	2	M47504
Pathway	PID_LYSOPHOSPHOLIPID_PATHWAY	NFKB1 ADCY5 ADCY8	9.45e-04	65	42	3	M15
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY5 ADCY8	1.01e-03	16	42	2	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY5 ADCY8	1.01e-03	16	42	2	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY5 ADCY8	1.01e-03	16	42	2	MM14492
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADCY5 ADCY8	1.01e-03	16	42	2	M39849
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY5 ADCY8	1.15e-03	17	42	2	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY5 ADCY8	1.15e-03	17	42	2	M47544
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	RPS6KA5 NFKB1	1.15e-03	17	42	2	MM15215
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	RPS6KA5 NFKB1 DUSP7	1.22e-03	71	42	3	M27382
Pathway	REACTOME_SIGNALING_BY_NTRKS	RPS6KA5 PCSK6 DUSP7	1.43e-03	75	42	3	MM14652
Pathway	REACTOME_ERK_MAPK_TARGETS	RPS6KA5 DUSP7	1.43e-03	19	42	2	MM14780
Pubmed	[ALPHA-ACTININS AND SIGNAL TRANSDUCTION PATHWAYS].	NFKB1 ACTN4	2.55e-06	2	56	2	26995963
Pubmed	Genetic markers of comorbid depression and alcoholism in women.	ADCY5 ADCY8	2.55e-06	2	56	2	23278386
Pubmed	Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells.	RPS6KA5 NFKB1	2.55e-06	2	56	2	30830503
Pubmed	Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo.	IRS1 FOXF2	2.55e-06	2	56	2	20009030
Pubmed	SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice.	TEAD2 WTIP DMRT1	5.96e-06	22	56	3	37039821
Pubmed	Conditional deletion of Cited2 results in defective corneal epithelial morphogenesis and maintenance.	CITED2 KRT12	7.63e-06	3	56	2	19632219
Pubmed	Ca2+ -stimulated adenylyl cyclases regulate ERK-dependent activation of MSK1 during fear conditioning.	RPS6KA5 ADCY8	7.63e-06	3	56	2	17196532
Pubmed	RelA/NF-kappaB transcription factor associates with alpha-actinin-4.	NFKB1 ACTN4	7.63e-06	3	56	2	18215660
Pubmed	MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis.	HLX MBD2	7.63e-06	3	56	2	24934598
Pubmed	Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect.	RPS6KA5 NFKB1	7.63e-06	3	56	2	17495961
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXD3 TEAD2 NFKB1 HLX DMRT1 TERF2 FOXF2 EVX2 TLX1	1.37e-05	908	56	9	19274049
Pubmed	Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex.	RPS6KA5 NFKB1	1.52e-05	4	56	2	20129940
Pubmed	HIV-1 Vpu - an ion channel in search of a job.	NFKB1 KCNK3	1.52e-05	4	56	2	23831603
Pubmed	α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function.	NFKB1 ACTN4	1.52e-05	4	56	2	25411248
Pubmed	E3 ubiquitin ligase Trim33 ubiquitylates Annexin A2 to promote NF-κB induced skin inflammation in psoriasis.	TRIM33 NFKB1	1.52e-05	4	56	2	36096861
Pubmed	The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts.	NFKB1 HNRNPD	1.52e-05	4	56	2	27248826
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ASXL1 CDV3 ABL2 NFKB1 ACTN4 SLC4A5	1.57e-05	332	56	6	37433992
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	MKRN4P CITED2 FOXD3 TEAD2 NFKB1 PCSK6 ZNF746 EVX2	1.72e-05	709	56	8	22988430
Pubmed	Role of Asxl1 in kidney podocyte development via its interaction with Wtip.	ASXL1 WTIP	5.32e-05	7	56	2	26385183
Pubmed	Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.	ADCY5 ADCY8	5.32e-05	7	56	2	12613887
Pubmed	NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway.	RPS6KA5 NFKB1	5.32e-05	7	56	2	18424438
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	TRIM33 ASXL1 FOXD3 TEAD2 NFKB1 PER1 MBD2 FOXF2	6.57e-05	857	56	8	25609649
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	KRT9 KRT12 ABL2 ACTN4 HNRNPD	7.00e-05	266	56	5	19380743
Pubmed	Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.	SLC4A5 SLC4A2	7.09e-05	8	56	2	26110920
Pubmed	A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample.	MEX3B ADCY8	7.09e-05	8	56	2	24677629
Pubmed	Negative feedback regulation of NF-κB action by CITED2 in the nucleus.	CITED2 NFKB1	7.09e-05	8	56	2	21098220
Pubmed	Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).	RPS6KA5 NFKB1	7.09e-05	8	56	2	12628924
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY5 ADCY8	9.10e-05	9	56	2	12503609
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY5 ADCY8	9.10e-05	9	56	2	17229090
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY5 ADCY8	1.14e-04	10	56	2	8663304
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY5 ADCY8	1.14e-04	10	56	2	16615126
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY5 ADCY8	1.14e-04	10	56	2	11884542
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	TRIM33 CDV3 USHBP1 NFKB1 DUSP7 SIK3 TERF2	1.16e-04	689	56	7	36543142
Pubmed	A human MAP kinase interactome.	SHANK1 ABL2 RPS6KA5 ACTN4 ANKRD24 SIK3	1.30e-04	486	56	6	20936779
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	NFKB1 ADCY8	1.39e-04	11	56	2	11299302
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY5 ADCY8	1.39e-04	11	56	2	10089566
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	ADCY5 ADCY8	1.39e-04	11	56	2	10808179
Pubmed	Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).	SLC4A5 SLC4A2	1.66e-04	12	56	2	21705333
Pubmed	HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.	ADCY5 ADCY8	1.66e-04	12	56	2	10807185
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY5 ADCY8	2.29e-04	14	56	2	14993377
Pubmed	Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.	NFKB1 SPINK5	2.29e-04	14	56	2	16519819
Pubmed	MD-2: the Toll 'gatekeeper' in endotoxin signalling.	RPS6KA5 NFKB1 DUSP7	2.36e-04	74	56	3	15276183
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	SP8 TEAD2 MBD2 EVX2	2.59e-04	191	56	4	24146773
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADCY5 ADCY8	3.01e-04	16	56	2	17567809
Pubmed	Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.	NFKB1 TLX1	3.01e-04	16	56	2	10687308
Pubmed	Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.	FOXD3 PCSK6	3.01e-04	16	56	2	20876279
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	NFKB1 IRS1 MBD2 TERF2 SLC4A2	3.41e-04	374	56	5	19625176
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	NFKB1 IRS1 MBD2 TERF2 SLC4A2	3.71e-04	381	56	5	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	NFKB1 IRS1 MBD2 TERF2 SLC4A2	3.76e-04	382	56	5	19170196
Pubmed	Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.	KRT9 PCSK6 RTN4R	3.94e-04	88	56	3	21491433
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	SP8 TEAD2 NFKB1 PER1 DMRT1 HNRNPD TLX1	5.01e-04	877	56	7	20211142
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	KRT9 CKAP4	5.24e-04	21	56	2	33029523
Pubmed	The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.	KRT9 KRT12 ACTN4	5.72e-04	100	56	3	21800051
Pubmed	The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.	FOXD3 PCSK6	5.76e-04	22	56	2	21896659
Pubmed	Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors.	NFKB1 SLC4A5	5.76e-04	22	56	2	33304758
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	NFKB1 IRS1 MBD2 TERF2 SLC4A2	5.84e-04	421	56	5	19692168
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ASXL1 STXBP5L SIK3	6.06e-04	102	56	3	10231032
Pubmed	Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.	ABL2 IRS1	6.87e-04	24	56	2	20624904
Pubmed	Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.	KRT9 KRT12	6.87e-04	24	56	2	27507811
Pubmed	Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo.	TRIM33 PCSK6	6.87e-04	24	56	2	20573697
Pubmed	Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.	ABL2 HECW1	7.46e-04	25	56	2	23873930
Pubmed	Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development.	DUSP7 PER1	7.46e-04	25	56	2	38834239
Pubmed	Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes.	KRT9 ACTN4	7.46e-04	25	56	2	16212417
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	KRT9 ABL2 NFKB1 SPINK5	7.91e-04	257	56	4	30945288
Pubmed	Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.	IRS1 ADCY5	8.71e-04	27	56	2	20490451
Pubmed	Interactions of viral protein U (Vpu) with cellular factors.	NFKB1 KCNK3	8.71e-04	27	56	2	20012522
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	HECW1 PCSK6 ACTN4	9.26e-04	118	56	3	21078624
Pubmed	Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line.	FOXD3 DMRT1	9.37e-04	28	56	2	23473982
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SHANK1 ABL2 ACTN4 SIK3	1.10e-03	281	56	4	28706196
Pubmed	c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.	FOXD3 TLX1	1.22e-03	32	56	2	22514301
Pubmed	SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.	ABL2 IRS1	1.22e-03	32	56	2	22974441
Pubmed	Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.	NFKB1 TERF2	1.30e-03	33	56	2	19817957
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	KRT9 HLX ACTN4 CKAP4	1.37e-03	298	56	4	30737378
Pubmed	The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.	FOXD3 DMRT1	1.38e-03	34	56	2	20007774
Pubmed	Proteomic analysis reveals novel binding partners of MIP-T3 in human cells.	KRT9 ACTN4	1.38e-03	34	56	2	20391533
Pubmed	Transcriptome analysis of human gastric cancer.	CITED2 CDV3 KCNC4 RTN4R ACTN4 HNRNPD	1.48e-03	772	56	6	16341674
Pubmed	TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3β-β-Catenin Signaling Pathway.	KRT9 ACTN4 CKAP4 HNRNPD	1.49e-03	305	56	4	33194618
Pubmed	Molecular composition of IMP1 ribonucleoprotein granules.	ACTN4 HNRNPD	1.55e-03	36	56	2	17289661
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY5 ADCY8	2.46e-04	10	43	2	53
GeneFamily	Keratins, type I	KRT9 KRT12	2.01e-03	28	43	2	608
GeneFamily	Ankyrin repeat domain containing	SHANK1 KANK3 NFKB1 ANKRD24	2.57e-03	242	43	4	403
GeneFamily	Forkhead boxes	FOXD3 FOXF2	4.69e-03	43	43	2	508
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	SP8 FOXD3 KCNC4 STXBP5L RTN4R KCNK3 CACNA1I FOXF2 TLX1	5.31e-08	350	56	9	M1949
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	SP8 FOXD3 KCNC4 STXBP5L RTN4R KCNK3 CACNA1I FOXF2 TLX1	6.29e-08	357	56	9	MM828
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	SP8 FOXD3 HECW1 RTN4R KCNK3 DMRT1 EVX2 TLX1	6.81e-07	345	56	8	M2009
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	SP8 FOXD3 HECW1 RTN4R KCNK3 DMRT1 EVX2 TLX1	7.11e-07	347	56	8	MM860
Coexpression	GSE20715_0H_VS_48H_OZONE_TLR4_KO_LUNG_UP	USHBP1 KANK3 KCNK3 HLX ADCY8 FOXF2	4.33e-06	200	56	6	M4379
Coexpression	TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_UP	CITED2 DUSP7 SPCS2 CKAP4	2.75e-05	81	56	4	M4552
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TOB2 WTIP KCNK3 ADCY5 FOXF2 MOB2	1.57e-07	193	56	6	7631bf3362b4fa061ffeab4879ab12c4708dc4c0
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TOB2 WTIP KCNK3 ADCY5 FOXF2 MOB2	1.57e-07	193	56	6	8d15c63f2ae48d0a00d7ef5fdafa917ab8ad0571
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNC4 WTIP USHBP1 KANK3 FOXF2	5.12e-06	199	56	5	1295f34a350bf48987e2fad411aaac3630efd3f1
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TRIM33 PCSK6 KCNK3 WDR81 SPINK5	5.25e-06	200	56	5	fe772d98c461c973dfc082e1fc50117c27ced804
ToppCell	Posterior_cortex\|World / BrainAtlas - Mouse McCarroll V32	KRT12 HECW1 RTN4R PER1	4.78e-05	159	56	4	18e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I SRPK3 DMRT1 TLX1	5.79e-05	167	56	4	691f3589de0f8c13f9137812cfa9040c07d237b4
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	RPS6KA5 PCSK6 KCNK3 MEX3B	6.49e-05	172	56	4	da959c1abadafd79b7a0088a25eb8ef8efa3a0c2
ToppCell	Ionocyte-iono-2\|World / Class top	KCNC4 NFKB1 KCNK3 ADCY5	6.63e-05	173	56	4	e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell	facs-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 ADCY5 ADCY8 FOXF2	7.57e-05	179	56	4	7078022e60faa86444f2a2c6eb9f767cc66b5cfa
ToppCell	facs-Heart-RA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TOB2 HECW1 WTIP ADCY5	7.57e-05	179	56	4	d76a05f1fee7f2f7b7b7994d3622e96f02b49432
ToppCell	facs-Heart-RA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TOB2 HECW1 WTIP ADCY5	7.57e-05	179	56	4	6be47c877250968a916c711ba0787eb7b4c5443d
ToppCell	facs-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 ADCY5 ADCY8 FOXF2	7.57e-05	179	56	4	d4a975d8ffa5e77fb5c0ec05bf9c8f843c77ce07
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KCNK3 IRS1 ADCY5 FOXF2	7.90e-05	181	56	4	25915e2500430a902db37d79a749ce2990b69810
ToppCell	ILEUM-inflamed-(5)_Plasma-(5)_IgM_plasma_cells\|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CDV3 PCSK6 SPCS2 CKAP4	8.60e-05	185	56	4	26ea60b6392410fab048f2e406a9860a018429cc
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KCNK3 IRS1 CKAP4 FOXF2	9.15e-05	188	56	4	c29aaae3c5bb7cd6b9b3defd4d27afde3af19ba0
ToppCell	droplet-Kidney-nan-3m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEAD2 USHBP1 KANK3 SPINK5	9.15e-05	188	56	4	67c04f446fa4528b13a381622e88eb1f314cc6d5
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNC4 USHBP1 KANK3 DUSP7	9.15e-05	188	56	4	0026c9479b30fb39daa91cfa220a88f9c9e65fe7
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEAD2 USHBP1 KANK3 SPINK5	9.15e-05	188	56	4	03a7f6538cfddc230c0eab10c3613929addd7e33
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HECW1 KCNK3 IRS1 FOXF2	9.15e-05	188	56	4	3004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HECW1 KCNK3 IRS1 FOXF2	9.34e-05	189	56	4	f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCell	droplet-Kidney-KIDNEY-1m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEAD2 USHBP1 KANK3 HLX	9.73e-05	191	56	4	767269dbd799e08c4ebba13e8c968fb148acf182
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ASXL1 NFKB1 PER1 SIK3	1.01e-04	193	56	4	dbf0fe496254320c894568c31e5f9ce63707d1b5
ToppCell	droplet-Bladder-nan-3m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USHBP1 KANK3 KCNK3 HLX	1.01e-04	193	56	4	8be24713f8ba2545b7647d1994e9e993623ddaa3
ToppCell	droplet-Bladder-nan-3m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USHBP1 KANK3 KCNK3 HLX	1.01e-04	193	56	4	19dfc4a2c91fcea4f5991e7c44df46faeecb06b8
ToppCell	droplet-Bladder-nan-3m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USHBP1 KANK3 KCNK3 HLX	1.01e-04	193	56	4	351e0acd411a9eb0dbc0e358d0d1e3759753fa40
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USHBP1 KANK3 HLX ACTN4	1.05e-04	195	56	4	5b84fd5be31386eb1d6048bbf28626032361842e
ToppCell	Fibroblasts-Pericytes\|Fibroblasts / lung cells shred on cell class, cell subclass, sample id	KCNK3 ACTN4 ADCY5 MOB2	1.05e-04	195	56	4	c2ebc0b33bda9b35b9ef26d69e5d2c6acfdb6ff1
ToppCell	facs-Lung-ENDOMUCIN\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USHBP1 KANK3 HLX ACTN4	1.07e-04	196	56	4	69f03546c42c942ab8ac8746167c8d44d574b4c6
ToppCell	facs-Lung-ENDOMUCIN-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USHBP1 KANK3 HLX ACTN4	1.07e-04	196	56	4	f6df26ab9eebae893768a4f70a064ce9f60da93c
ToppCell	PBMC\|World / Compartment, Disease Groups and Clusters	CDV3 PER1 MBD2 HNRNPD	1.12e-04	198	56	4	84f5b43dad0c57556171dbc0b799735654582ecf
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	USHBP1 KANK3 ACTN4 FOXF2	1.12e-04	198	56	4	72e8b9cccb7b0a2ea9d415218fff4fa2f09728f4
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Smooth_muscle-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	WTIP KANK3 KCNK3 ADCY5	1.14e-04	199	56	4	2c5ad62919c64ea0242e0984bb9932d2d975f4e3
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNC4 USHBP1 KANK3 FOXF2	1.14e-04	199	56	4	0602e2b2aa56d106da63bd342a38bef437b4d496
ToppCell	LPS_only-Unknown\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHANK1 FBXO45 ADCY5	4.09e-04	115	56	3	7a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCell	LPS_only-Unknown-Endothelial-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHANK1 FBXO45 ADCY5	4.09e-04	115	56	3	c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCell	LPS_only-Unknown-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHANK1 FBXO45 ADCY5	4.09e-04	115	56	3	ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCell	COVID-19_Mild-Neu_1\|World / 5 Neutrophil clusters in COVID-19 patients	HECW1 USHBP1 DMRT1	5.21e-04	125	56	3	e58c208b4355252ceabe04a468dd19a1f436182c
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-6\|TCGA-Lung / Sample_Type by Project: Shred V9	USHBP1 KANK3 KCNK3	5.33e-04	126	56	3	b49b15ba1458488f98d54e87100257a12ee34076
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	STXBP5L KANK3 SLC4A5	6.11e-04	132	56	3	780a391924f776dc6fbe44ddcf4ae0583a1e2157
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USHBP1 KANK3 HLX	6.11e-04	132	56	3	fc79898eeb39c26505cf04df95c3dd75a6593295
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	STXBP5L KANK3 SLC4A5	6.52e-04	135	56	3	366a417f9ef7c0d86e9f262d97bf788f478315ee
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SHANK1 SP8 CDV3	6.80e-04	137	56	3	ed81624b9167255ce88dcf6ad7f1636376ea0525
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell-Mesenchymal_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SHANK1 SP8 CDV3	6.80e-04	137	56	3	47859aa25f32367461c1ec75ed9060bee430c6b7
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACTN4 HNRNPD SPINK5	6.95e-04	138	56	3	5f8ac8f67e34a7cf560099208e6884102532391e
ToppCell	control-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	WTIP DUSP7 PER1	8.18e-04	146	56	3	69e9c1ec6eec1151290227902e75e77a4aecc8db
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Thalamus / BrainAtlas - Mouse McCarroll V32	SP8 KCNC4 CACNA1I	8.51e-04	148	56	3	afebb64365c94b9476494bffe7c364677f19c8cf
ToppCell	Thalamus-Neuronal-Inhibitory\|Thalamus / BrainAtlas - Mouse McCarroll V32	SP8 KCNC4 CACNA1I	8.51e-04	148	56	3	5f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 ADCY5 SPINK5	8.85e-04	150	56	3	aa11579a57d671a55e64183d35c1340fda6dec14
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT12 USHBP1 KANK3	8.85e-04	150	56	3	96b160f163030fbf48aedc37d6ae224e11492c52
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 ADCY5 SPINK5	9.37e-04	153	56	3	82b77c8bae49dd63b8f10eb67df66ca71d0bb315
ToppCell	mild_COVID-19_(asymptomatic)-NK_CD56bright\|World / disease group, cell group and cell class (v2)	HECW1 RTN4R DUSP7	9.37e-04	153	56	3	aff5c8ab1fb4ebc324cec02cf562b7484bb10db8
ToppCell	Ionocyte\|World / shred by cell class for nasal brushing	TEAD2 SRPK3 ADCY5	9.54e-04	154	56	3	6b78fb0c96fc7b5e901c39b3424f4aa8d0a6b9cf
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLX SRPK3 IRS1	9.72e-04	155	56	3	d10cf5e922dbd3ca46660404da5aca43f181fc19
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KCNK3 ADCY5 FOXF2	9.91e-04	156	56	3	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KCNK3 ADCY5 FOXF2	1.01e-03	157	56	3	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KRT12 RTN4R CACNA1I	1.01e-03	157	56	3	5aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RTN4R WDR81 FOXF2	1.01e-03	157	56	3	1e3a4a7193d95f09d71c2dfe704b8e626c6d9624
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HECW1 IRS1 FOXF2	1.01e-03	157	56	3	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KANK3 KCNK3 FOXF2	1.05e-03	159	56	3	7a5c94c87b73f928d4daee507f32cbe7d90e4478
ToppCell	Bronchial_Brush-Epithelial-Goblet_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SP8 APOBR MEX3B	1.05e-03	159	56	3	95834b767cfb4fb8c5aeea89c10f3e14a1fd15c1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRIM33 ACTN4 APOBR	1.08e-03	161	56	3	bf4bfb416cb6ef43fc8cf0ffc2d7f0b6b42ab4da
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNK3 SRPK3 MEX3B	1.10e-03	162	56	3	478cf560ef33c5c324142c76417447d4a571a2c9
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KANK3 KCNK3 FOXF2	1.10e-03	162	56	3	c5eee02836efde2108534679850c28d2b2cfce3f
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KCNC4 KCNK3 ADCY5	1.12e-03	163	56	3	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK\|Cerebellum / BrainAtlas - Mouse McCarroll V32	USHBP1 KANK3 HLX	1.16e-03	165	56	3	7d319a112b9062efee428bef6f4534d2ce782e04
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 RTN4R ADCY8	1.16e-03	165	56	3	02cd87dfa2ca40e13455a4b9308477e82f76289b
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 RTN4R ADCY8	1.16e-03	165	56	3	6d8b5669eee9b0903c9260fea707d186c9d7fefa
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NFKB1 RTN4R FOXF2	1.18e-03	166	56	3	3b67064a5149e72f895344d938c64b8ff65247f5
ToppCell	NS-control-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	USHBP1 SRPK3 ADCY5	1.18e-03	166	56	3	6d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HECW1 STXBP5L DMRT1	1.21e-03	167	56	3	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	3'_v3-Lung-Lymphocytic_Invariant-Inducer-like-ILC3\|Lung / Manually curated celltypes from each tissue	SHANK1 NFKB1 MEX3B	1.21e-03	167	56	3	0614d077b47a87f726068615548d0b0a216627be
ToppCell	(0)_Myeloid-(00)_Monocyte-(000)_CD14+_Monocyte\|(00)_Monocyte / immune cells in Peripheral Blood (logTPM normalization)	PER1 CKAP4 APOBR	1.21e-03	167	56	3	7d9fd6a7a45c2aa0d5f2e3960ca4c97ee8836ba5
ToppCell	BAL-Severe-cDC_5\|Severe / Compartment, Disease Groups and Clusters	ABL2 NFKB1 PER1	1.23e-03	168	56	3	857a80c217a5513553460798a625612031bc7bb7
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLX CKAP4 APOBR	1.23e-03	168	56	3	c0ff30e2c47005514131a0866cf10a1c228128fc
ToppCell	NS-critical-d_16-33-Epithelial-Ionocyte\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TEAD2 USHBP1 ADCY5	1.23e-03	168	56	3	6a233045638cb83dab64789b996b7598c325001e
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APOBR ADCY5 SPINK5	1.25e-03	169	56	3	1dfaf9a6b433a5ee86a11962af188978c2543278
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APOBR ADCY5 SPINK5	1.25e-03	169	56	3	3e267ec9f884df326315500dfd751b04a3dd91bd
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLX CKAP4 APOBR	1.25e-03	169	56	3	1000eaf5158596b4898bedcc802b31db76b05a48
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLX CKAP4 APOBR	1.25e-03	169	56	3	83b854fa8fd9017df8f9207d9ced260eee98e8c1
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 KRT9 TLX1	1.27e-03	170	56	3	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 KRT9 TLX1	1.27e-03	170	56	3	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	Ionocyte\|World / Class top	KCNC4 KCNK3 ADCY5	1.27e-03	170	56	3	d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCell	droplet-Marrow-BM-1m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CITED2 HLX CKAP4	1.29e-03	171	56	3	8a0c08f0aa3a80cd6346c81deb242e430ebd897b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 KRT12 KCNK3	1.31e-03	172	56	3	0f2771e1e24fd2235ceb96663f0513b4dd6552d1
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR81 SRPK3 MEX3B	1.33e-03	173	56	3	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 TEAD2 SLC4A5	1.33e-03	173	56	3	f612d4ea9ab8dcde475f4118bca3e49be786e7fa
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 TEAD2 SLC4A5	1.33e-03	173	56	3	c62e3ffed55bbb00dcaef6da0aab8446f3f55085
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNK3 ADCY8 FOXF2	1.33e-03	173	56	3	cbd65dd5b01cc959e3ccbc89330ddd0122296ea3
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNK3 ADCY8 FOXF2	1.33e-03	173	56	3	f9d6e892d66f9b94e4d5beb9f5dec9b606bc868a
ToppCell	Adult-Mesenchymal-pericyte_cell-D175\|Adult / Lineage, Cell type, age group and donor	KCNK3 ADCY5 FOXF2	1.33e-03	173	56	3	fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 ADCY8 FOXF2	1.33e-03	173	56	3	3059325901b1e5e12a1a91183f14267288b2f600
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 ADCY8 FOXF2	1.33e-03	173	56	3	36c8338463ee4cc432f568728d55989360f9a68d
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TEAD2 USHBP1 ADCY5	1.36e-03	174	56	3	b7f5492ce8098f7eb0aef30ee558d00738d59d0e
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TEAD2 USHBP1 ADCY5	1.36e-03	174	56	3	cafe4d6b5f08d8888e9db6e196c66df991c03e7b
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TEAD2 USHBP1 ADCY5	1.36e-03	174	56	3	71730503be3d9c839c4c9e950145e2101d682a1c
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-6\|TCGA-Pancreas / Sample_Type by Project: Shred V9	USHBP1 KANK3 ADCY5	1.36e-03	174	56	3	9ad13d4613c4f80bdd8033cc1ecf60eda7c0e6e5
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KCNK3 ADCY8 FOXF2	1.36e-03	174	56	3	a7ade7372e83edd4e3983e77f8417b51f0b47340
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TEAD2 USHBP1 ADCY5	1.36e-03	174	56	3	ee8ac51fa0b426ad7b7453371bb79c8bf8c1d358
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 ADCY8 FOXF2	1.38e-03	175	56	3	a7310950e8d51b3004ea3aee8ce9948fe8655112
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MISP3 CKAP4 EVX2	1.38e-03	175	56	3	019ea30ac55748463d7917abf3d3f0e804189bfd
Drug	Practolol [6673-35-4]; Up 200; 15uM; PC3; HT_HG-U133A	KRT12 STXBP5L KANK3 PCSK6 MBD2 SLC4A5	9.07e-06	198	56	6	4603_UP
Drug	Gabapentin [60142-96-3]; Up 200; 23.4uM; PC3; HT_HG-U133A	CITED2 KRT9 ABL2 HECW1 PCSK6 SPINK5	9.07e-06	198	56	6	5875_UP
Disease	beta-amyloid 1-42 measurement, cerebrospinal fluid biomarker measurement	HECW1 HLX	3.06e-04	14	55	2	EFO_0004670, EFO_0006794
Disease	anemia (implicated_via_orthology)	SLC4A5 SLC4A2	3.53e-04	15	55	2	DOID:2355 (implicated_via_orthology)
Disease	schizophrenia (is_implicated_in)	RTN4R CACNA1I MBD2	4.22e-04	78	55	3	DOID:5419 (is_implicated_in)
Disease	diverticular disease	SP8 HECW1 KCNK3 HLX	9.88e-04	236	55	4	EFO_0009959
Disease	right ventricular diastolic volume measurement	KCNK3 ACTN4	1.25e-03	28	55	2	EFO_0021814
Disease	Myeloid Leukemia, Chronic	ASXL1 PER1	1.34e-03	29	55	2	C0023473
Disease	allergic disease	TOB2 NFKB1 MBD2 APOBR	1.37e-03	258	55	4	MONDO_0005271
Disease	asthma, Eczema, allergic rhinitis	TOB2 NFKB1 FBXO45	1.51e-03	121	55	3	EFO_0005854, HP_0000964, MONDO_0004979
Disease	Adult T-Cell Lymphoma/Leukemia	TERF2 TLX1	1.53e-03	31	55	2	C0023493
Disease	Neoplastic Cell Transformation	NFKB1 IRS1 TLX1	2.24e-03	139	55	3	C0007621
Disease	Secondary Biliary Cholangitis	NFKB1 SLC4A2	2.80e-03	42	55	2	C0238065
Disease	Biliary cirrhosis	NFKB1 SLC4A2	2.80e-03	42	55	2	C0023892
Disease	Biliary Cirrhosis, Primary, 1	NFKB1 SLC4A2	2.80e-03	42	55	2	C4551595
Disease	free cholesterol to total lipids in IDL percentage	PCSK6 SIK3	2.93e-03	43	55	2	EFO_0022278
Disease	cholesteryl esters to total lipids in small HDL percentage	PCSK6 SIK3	2.93e-03	43	55	2	EFO_0022254
Disease	Primary biliary cirrhosis	NFKB1 SLC4A2	3.49e-03	47	55	2	C0008312
Disease	mean reticulocyte volume	CITED2 TRIM33 TOB2 NFKB1 MBD2 MEX3B	3.63e-03	799	55	6	EFO_0010701
Disease	cholesterol to total lipids in small HDL percentage	PCSK6 SIK3	4.10e-03	51	55	2	EFO_0022240
Disease	cholesterol to total lipids in small VLDL percentage	PCSK6 SIK3	4.10e-03	51	55	2	EFO_0022242

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGANSSGGHSSGGGS	USHBP1	541	Q8N6Y0
SGGHSSGGGSSGDEE	USHBP1	546	Q8N6Y0
GGSGSGSGGSGKASD	ADCY8	56	P40145
ERSGSGSASGSGGGG	ADCY8	111	P40145
VASGTAGGDDGGASG	SLC4A2	206	P04920
GGGGGGGKSSSSSSA	CKAP4	71	Q07065
NLCNDDGGGGGGSGT	ABL2	726	P42684
GSGGSAALGGSGSGA	EVX2	171	Q03828
SSAGNGAGGGGSMGD	ACTN4	16	O43707
GAVEGGEGSGDGGSS	ADCY5	176	O95622
GEGSGDGGSSADSGS	ADCY5	181	O95622
DGGSSADSGSGAGPG	ADCY5	186	O95622
AEGSGASGGGGGDTT	ANKRD24	771	Q8TF21
GSAGGSSGAAGAAGG	CDV3	36	Q9UKY7
SSGAAGAAGGGAGAG	CDV3	41	Q9UKY7
GGGATDEGGGRGSSS	ASXL1	651	Q8IXJ9
DEGGGRGSSSGDGGE	ASXL1	656	Q8IXJ9
GSDGSDGSGGRGDSG	MKRN4P	51	Q13434
AGGVHSGGSGDGAGS	MOB2	211	Q70IA6
AGSGGSSGGGGNSFS	HLX	421	Q14774
SSGFGGGSGSSMAGG	KRT12	66	Q99456
SGGSYGGGEEASGSG	KRT9	596	P35527
AGHGSSGGGGGNTQD	SPINK5	691	Q9NQ38
GGGGGGGSAHTTDTA	KCNK3	271	O14649
AGGGGGGGSDSEAES	HECW1	911	Q76N89
GLGSGSGSGSHEGGS	PER1	1066	O15534
GEQGSSGGGSGEGEG	PER1	1236	O15534
TDTAAGAGGAGGAGG	PCSK6	21	P29122
GSSGGAAGTSADGGD	RPS6KA5	6	O75582
ALGAGGGGGSCSGSS	IRS1	126	P35568
GGGGSCSGSSGLGEA	IRS1	131	P35568
EGESAAGGSGAGGDS	MBD2	16	Q9UBB5
GAGAGAGSGSGAAGA	FBXO45	21	P0C2W1
DSGQEGSGSGSSAGG	CACNA1I	571	Q9P0X4
GSGAGTGAGAATGAG	DUSP7	36	Q16829
GSSSGSGDDSGGGSD	KANK3	501	Q6NY19
SGDDSGGGSDSGTPG	KANK3	506	Q6NY19
SAGGSSRGGGSGSGA	DMRT1	46	Q9Y5R6
AGGTGGSGGGSTAQS	FOXD3	401	Q9UJU5
GGGGGGDYGPDSSSS	FOXF2	301	Q12947
GGGGGSSGGGETLDD	MEX3B	16	Q6ZN04
GAAAAAGSGAGTGGG	HNRNPD	36	Q14103
GTGGGTASGGTEGGS	HNRNPD	46	Q14103
LGQAGSGGGGTGDSE	RTN4R	431	Q9BZR6
SGGGGTGDSEGSGAL	RTN4R	436	Q9BZR6
GGGEAESGGGGSGSA	TRIM33	6	Q9UPN9
ASGAGGAAGAGTGGA	SIK3	6	Q9Y2K2
EGSEEGTGGSEGAGG	TEAD2	21	Q15562
SGEEAGAGGSISSGG	TEAD2	311	Q15562
GSSSGSNSGGGAGSG	STXBP5L	21	Q9Y2K9
GGGGGGGSSAHSQDG	SP8	141	Q8IXZ3
GGSGGGGDSHHGGAS	SHANK1	1896	Q9Y566
MSASTGGGGDSGGSG	SRPK3	1	Q9UPE1
GGGGDSGGSGGSSSS	SRPK3	6	Q9UPE1
SGGEAGTASGGEEAG	APOBR	341	Q0VD83
GTASGGEEAGTASGG	APOBR	346	Q0VD83
SSSGGGAGSSNSGGG	CITED2	181	Q99967
GAGSSNSGGGSGSGN	CITED2	186	Q99967
GGAGTSGAGGSGASV	ZNF865	531	P0CJ78
AAGSGSSAGAGDGAG	MISP3	106	Q96FF7
SGGSGGCSGAGGASN	SPCS2	11	Q15005
GAGSGGAGGTSSGDD	SLC4A5	461	Q9BY07
GGGSSGGAGALSAAG	TLX1	116	P31314
ASLAGSDGGGGGGSA	WTIP	91	A6NIX2
SDGGGGGGSARSSGI	WTIP	96	A6NIX2
GGGSGGGSARDGSAL	ZNF746	496	Q6NUN9
GGSEEASGAGVGSGG	ZC3H10	21	Q96K80
DARGGGGTGGGSTGS	ZC3H10	166	Q96K80
GAASGGGVASSGAGG	TOB2	196	Q14106
DTMAGGGGSSDGSGR	TERF2	41	Q15554
SGVGGGGLGSGSDDN	WDR81	1586	Q562E7
TDGGGVGSSGSSGGG	KCNC4	76	Q03721
SDSFGGGSGAGAGGG	NFKB1	371	P19838