Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	piRNA binding	PIWIL1 PIWIL4 PIWIL3	2.00e-06	6	94	3	GO:0034584
GeneOntologyMolecularFunction	L-cystine transmembrane transporter activity	SLC1A4 SLC3A1	1.31e-04	4	94	2	GO:0015184
GeneOntologyCellularComponent	pole plasm	PIWIL1 PIWIL4 PIWIL3	2.96e-04	29	94	3	GO:0045495
GeneOntologyCellularComponent	germ plasm	PIWIL1 PIWIL4 PIWIL3	2.96e-04	29	94	3	GO:0060293
GeneOntologyCellularComponent	P granule	PIWIL1 PIWIL4 PIWIL3	2.96e-04	29	94	3	GO:0043186
GeneOntologyCellularComponent	aryl hydrocarbon receptor complex	ARNT ARNT2	5.50e-04	8	94	2	GO:0034751
Domain	PIWI	PIWIL1 PIWIL4 PIWIL3	6.36e-06	8	92	3	PS50822
Domain	Piwi	PIWIL1 PIWIL4 PIWIL3	6.36e-06	8	92	3	SM00950
Domain	Piwi	PIWIL1 PIWIL4 PIWIL3	6.36e-06	8	92	3	IPR003165
Domain	Piwi	PIWIL1 PIWIL4 PIWIL3	6.36e-06	8	92	3	PF02171
Domain	PAZ	PIWIL1 PIWIL4 PIWIL3	9.51e-06	9	92	3	PS50821
Domain	PAZ	PIWIL1 PIWIL4 PIWIL3	9.51e-06	9	92	3	SM00949
Domain	PAZ_dom	PIWIL1 PIWIL4 PIWIL3	9.51e-06	9	92	3	IPR003100
Domain	PAZ	PIWIL1 PIWIL4 PIWIL3	9.51e-06	9	92	3	PF02170
Domain	PAS_fold_3	HIF1A ARNT ARNT2	1.91e-04	23	92	3	IPR013655
Domain	PAS_3	HIF1A ARNT ARNT2	1.91e-04	23	92	3	PF08447
Domain	PAS-assoc_C	HIF1A ARNT ARNT2	2.17e-04	24	92	3	IPR000700
Domain	PAS	HIF1A ARNT ARNT2	2.46e-04	25	92	3	PF00989
Domain	PAS_fold	HIF1A ARNT ARNT2	2.46e-04	25	92	3	IPR013767
Domain	PAC	HIF1A ARNT ARNT2	2.77e-04	26	92	3	IPR001610
Domain	PAC	HIF1A ARNT ARNT2	2.77e-04	26	92	3	SM00086
Domain	PAC	HIF1A ARNT ARNT2	2.77e-04	26	92	3	PS50113
Domain	C2	OTOF CADPS SYT14 PLCB2 BCR	4.75e-04	131	92	5	PF00168
Domain	PAS	HIF1A ARNT ARNT2	5.17e-04	32	92	3	SM00091
Domain	C2	OTOF CADPS SYT14 PLCB2 BCR	5.82e-04	137	92	5	SM00239
Domain	PAS	HIF1A ARNT ARNT2	6.20e-04	34	92	3	IPR000014
Domain	PAS	HIF1A ARNT ARNT2	6.20e-04	34	92	3	PS50112
Domain	Nuc_translocat	ARNT ARNT2	6.59e-04	8	92	2	IPR001067
Domain	C2	OTOF CADPS SYT14 PLCB2 BCR	6.85e-04	142	92	5	PS50004
Domain	C2_dom	OTOF CADPS SYT14 PLCB2 BCR	1.31e-03	164	92	5	IPR000008
Domain	-	PIWIL1 PIWIL4 PIWIL3	1.60e-03	47	92	3	3.30.420.10
Domain	-	CSMD2 ZZEF1 CRHBP	2.15e-03	52	92	3	2.60.120.290
Domain	PI3/4_kinase_CS	PI4KA ATM	2.42e-03	15	92	2	IPR018936
Domain	-	PI4KA ATM	2.75e-03	16	92	2	1.10.1070.11
Domain	PI3Kc	PI4KA ATM	2.75e-03	16	92	2	SM00146
Domain	CUB_dom	CSMD2 ZZEF1 CRHBP	2.79e-03	57	92	3	IPR000859
Domain	PI3/4_kinase_cat_dom	PI4KA ATM	3.49e-03	18	92	2	IPR000403
Domain	PI3_PI4_kinase	PI4KA ATM	3.49e-03	18	92	2	PF00454
Domain	PI3_4_KINASE_3	PI4KA ATM	3.49e-03	18	92	2	PS50290
Domain	PI3_4_KINASE_1	PI4KA ATM	3.49e-03	18	92	2	PS00915
Domain	PI3_4_KINASE_2	PI4KA ATM	3.49e-03	18	92	2	PS00916
Domain	Zinc_finger_PHD-type_CS	ZMYND11 ASH1L PHF21A	4.05e-03	65	92	3	IPR019786
Domain	RNaseH-like_dom	PIWIL1 PIWIL4 PIWIL3	4.79e-03	69	92	3	IPR012337
Domain	Kinase-like_dom	JAK1 FLT1 DST PI4KA AAK1 ATM CDK14 CDC7	5.27e-03	542	92	8	IPR011009
Domain	PHD	ZMYND11 ASH1L PHF21A	6.05e-03	75	92	3	PF00628
Pubmed	Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.	PIWIL1 PIWIL4 PIWIL3	8.14e-08	4	96	3	20940137
Pubmed	Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.	HIF1A ARNT ARNT2	2.03e-07	5	96	3	9545558
Pubmed	Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development.	HIF1A ARNT ARNT2	4.05e-07	6	96	3	11025203
Pubmed	Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.	HIF1A ARNT ARNT2	4.05e-07	6	96	3	17826745
Pubmed	Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis.	HIF1A ARNT ARNT2	4.05e-07	6	96	3	8927054
Pubmed	A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.	FLT1 HIF1A ARNT	7.08e-07	7	96	3	9113979
Pubmed	Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.	HIF1A ARNT ARNT2	1.13e-06	8	96	3	11782478
Pubmed	Identification of eight members of the Argonaute family in the human genome.	PIWIL1 PIWIL4 PIWIL3	1.69e-06	9	96	3	12906857
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRMT6 PPP2R5C DST AAK1 LHFPL2 CDK14 ZZEF1 BCR PHF21A CEMIP2	2.13e-06	529	96	10	14621295
Pubmed	HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature.	HIF1A ARNT ARNT2	2.41e-06	10	96	3	16824955
Pubmed	Detrimental effects of hypoxia on glomerular podocytes.	HIF1A ARNT	7.54e-06	2	96	2	33835424
Pubmed	Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney.	ARNT ARNT2	7.54e-06	2	96	2	15466261
Pubmed	A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT.	HIF1A ARNT	7.54e-06	2	96	2	27362802
Pubmed	ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.	ATM CDC7	7.54e-06	2	96	2	32877678
Pubmed	Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.	HIF1A ARNT	7.54e-06	2	96	2	15987772
Pubmed	Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.	HIF1A ARNT	7.54e-06	2	96	2	20440072
Pubmed	Molecular characterization of the murine Hif-1 alpha locus.	HIF1A ARNT	7.54e-06	2	96	2	9368100
Pubmed	Purification and characterization of hypoxia-inducible factor 1.	HIF1A ARNT	7.54e-06	2	96	2	7836384
Pubmed	Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1alpha activation cascade: implications for HIF-1alpha gene therapy.	HIF1A ARNT	7.54e-06	2	96	2	11606485
Pubmed	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.	HIF1A ARNT	7.54e-06	2	96	2	7539918
Pubmed	Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor.	HIF1A ARNT	7.54e-06	2	96	2	23363003
Pubmed	Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency.	HIF1A ARNT	7.54e-06	2	96	2	10777486
Pubmed	Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators.	HIF1A ARNT	7.54e-06	2	96	2	14638687
Pubmed	Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts.	FLT1 ARNT	7.54e-06	2	96	2	34665260
Pubmed	HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity.	HIF1A ARNT	7.54e-06	2	96	2	25904334
Pubmed	Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor.	HIF1A ARNT	7.54e-06	2	96	2	9159130
Pubmed	The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia.	HIF1A ARNT	7.54e-06	2	96	2	10873592
Pubmed	Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1.	HIF1A ARNT	7.54e-06	2	96	2	17213817
Pubmed	Crystal structure of human CDC7 kinase in complex with its activator DBF4.	DBF4 CDC7	7.54e-06	2	96	2	23064647
Pubmed	Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha.	HIF1A ARNT	7.54e-06	2	96	2	8702901
Pubmed	Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1α.	HIF1A NMBR	7.54e-06	2	96	2	24349381
Pubmed	A dominant-negative isoform of hypoxia-inducible factor-1 alpha specifically expressed in human testis.	HIF1A ARNT	7.54e-06	2	96	2	15031145
Pubmed	Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning.	HIF1A ARNT	7.54e-06	2	96	2	22699503
Pubmed	Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol.	HIF1A ARNT	7.54e-06	2	96	2	12391259
Pubmed	Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.	FLT1 HIF1A	7.54e-06	2	96	2	16574650
Pubmed	Non-hypoxic transcriptional activation of the aryl hydrocarbon receptor nuclear translocator in concert with a novel hypoxia-inducible factor-1alpha isoform.	HIF1A ARNT	7.54e-06	2	96	2	15479785
Pubmed	Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes.	HIF1A YY1	7.54e-06	2	96	2	20105288
Pubmed	Yin Yang 1 facilitates hepatocellular carcinoma cell lipid metabolism and tumor progression by inhibiting PGC-1β-induced fatty acid oxidation.	PPARGC1B YY1	7.54e-06	2	96	2	31695789
Pubmed	Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha.	HIF1A ARNT	7.54e-06	2	96	2	10085255
Pubmed	Expression of hypoxia-inducible factor 1: mechanisms and consequences.	HIF1A ARNT	7.54e-06	2	96	2	10605934
Pubmed	Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses.	ARNT ARNT2	7.54e-06	2	96	2	17023418
Pubmed	Site-directed mutagenesis studies of the hypoxia-inducible factor-1alpha DNA-binding domain.	HIF1A ARNT	7.54e-06	2	96	2	12393189
Pubmed	Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1.	HIF1A ARNT	7.54e-06	2	96	2	8663540
Pubmed	Activation of HIF-1α does not increase intestinal tumorigenesis.	HIF1A APC	7.54e-06	2	96	2	24875099
Pubmed	Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure.	ARNT YY1	7.54e-06	2	96	2	29664738
Pubmed	Developmental stage-specific expression of the alpha and beta subunits of the HIF-1 protein in the mouse and human fetus.	HIF1A ARNT	7.54e-06	2	96	2	11914036
Pubmed	Targeting the PAS-A domain of HIF-1alpha for development of small molecule inhibitors of HIF-1.	HIF1A ARNT	7.54e-06	2	96	2	16861921
Pubmed	Bacterially produced human HIF-1alpha is competent for heterodimerization and specific DNA-binding.	HIF1A ARNT	7.54e-06	2	96	2	15850782
Pubmed	Hypoxia-inducible factor-1β (HIF-1β) is upregulated in a HIF-1α-dependent manner in 518A2 human melanoma cells under hypoxic conditions.	HIF1A ARNT	7.54e-06	2	96	2	23541582
Pubmed	DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways.	DBF4 CDC7	7.54e-06	2	96	2	28448802
Pubmed	Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection.	HIF1A APC	7.54e-06	2	96	2	20844082
Pubmed	Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.	HIF1A ARNT	7.54e-06	2	96	2	18762723
Pubmed	Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice.	HIF1A ARNT	7.54e-06	2	96	2	21873554
Pubmed	Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition.	DBF4 CDC7	7.54e-06	2	96	2	21536671
Pubmed	A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells.	DBF4 CDC7	7.54e-06	2	96	2	10373557
Pubmed	The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.	APC ATP5F1A	7.54e-06	2	96	2	17387143
Pubmed	The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells.	HIF1A ARNT	7.54e-06	2	96	2	8662957
Pubmed	A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene.	HIF1A ARNT	7.54e-06	2	96	2	11829741
Pubmed	Atm is a negative regulator of intestinal neoplasia.	APC ATM	7.54e-06	2	96	2	17700532
Pubmed	Role of HIF-1α in Alcohol-Mediated Multiple Organ Dysfunction.	HIF1A ARNT	7.54e-06	2	96	2	30544759
Pubmed	Optical analysis of the HIF-1 complex in living cells by FRET and FRAP.	HIF1A ARNT	7.54e-06	2	96	2	17197389
Pubmed	Piwi-like 1 and 4 gene transcript levels are associated with clinicopathological parameters in renal cell carcinomas.	PIWIL1 PIWIL4	7.54e-06	2	96	2	24509249
Pubmed	Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1.	FLT1 HIF1A	7.54e-06	2	96	2	16627691
Pubmed	DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling.	DBF4 CDC7	7.54e-06	2	96	2	30157471
Pubmed	Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation.	DBF4 CDC7	7.54e-06	2	96	2	18714392
Pubmed	PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine.	PPARGC1B APC	7.54e-06	2	96	2	25288742
Pubmed	Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide.	HIF1A ARNT	7.54e-06	2	96	2	20932347
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	IPO5 JAK1 DST OTOF KLHL7 CADPS VPS35L ASH1L APC CHMP3 ATM BTRC ATP5F1A DOP1B	1.17e-05	1285	96	14	35914814
Pubmed	Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation.	JAK1 FLT1 HIF1A ARNT	1.23e-05	51	96	4	26764350
Pubmed	Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.	HIF1A ARNT ARNT2	2.25e-05	20	96	3	20495570
Pubmed	Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut.	HIF1A ARNT	2.26e-05	3	96	2	17607366
Pubmed	HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts.	FLT1 HIF1A	2.26e-05	3	96	2	30478339
Pubmed	Relationship between hypoxia and downstream pathogenic pathways in preeclampsia.	FLT1 HIF1A	2.26e-05	3	96	2	28067578
Pubmed	The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.	DBF4 CDC7	2.26e-05	3	96	2	19111665
Pubmed	Regulation of hypoxia-inducible genes by ETS1 transcription factor.	HIF1A ARNT	2.26e-05	3	96	2	18381358
Pubmed	Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression.	HIF1A ARNT	2.26e-05	3	96	2	12810720
Pubmed	DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach.	DBF4 CDC7	2.26e-05	3	96	2	27407105
Pubmed	Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation.	HIF1A ARNT	2.26e-05	3	96	2	21814490
Pubmed	Hepatic Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) regulates metabolism in mice.	HIF1A ARNT	2.26e-05	3	96	2	29190746
Pubmed	Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia.	APC ATP5F1A	2.26e-05	3	96	2	11779834
Pubmed	Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.	HIF1A YY1	2.26e-05	3	96	2	23328582
Pubmed	Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer.	DBF4 CDC7	2.26e-05	3	96	2	29209046
Pubmed	Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells.	HIF1A ARNT	2.26e-05	3	96	2	22028336
Pubmed	DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.	DBF4 CDC7	2.26e-05	3	96	2	38865090
Pubmed	Hypoxia-inducible factors in the first trimester human lung.	FLT1 HIF1A	2.26e-05	3	96	2	17189520
Pubmed	VEGF expression is regulated by HIF-1α and ARNT in 3D KYSE-70, esophageal cancer cell spheroids.	HIF1A ARNT	2.26e-05	3	96	2	27542820
Pubmed	cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).	ARNT ARNT2	2.26e-05	3	96	2	8657146
Pubmed	Selected Genetic Polymorphisms Associated with Hypoxia and Multidrug Resistance in Monoclonal Gammopathies Patients.	HIF1A ARNT	2.26e-05	3	96	2	30441975
Pubmed	Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina.	HIF1A ARNT	2.26e-05	3	96	2	24664708
Pubmed	MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta.	HIF1A ARNT	2.26e-05	3	96	2	20478051
Pubmed	Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression.	FNIP2 BTRC	2.26e-05	3	96	2	28039480
Pubmed	Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture.	ARNT ARNT2	2.26e-05	3	96	2	18096572
Pubmed	HIF1 activity in granulosa cells is required for FSH-regulated Vegfa expression and follicle survival in mice.	HIF1A ARNT	2.26e-05	3	96	2	24855100
Pubmed	Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis.	HIF1A APC	2.26e-05	3	96	2	31043706
Pubmed	Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity.	DBF4 CDC7	2.26e-05	3	96	2	19864417
Pubmed	Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis.	HIF1A APC	2.26e-05	3	96	2	20194889
Pubmed	Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.	HIF1A ARNT	2.26e-05	3	96	2	14668441
Pubmed	Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.	HIF1A ATM	2.26e-05	3	96	2	29860718
Pubmed	Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.	HIF1A ARNT	2.26e-05	3	96	2	16007214
Pubmed	Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.	DBF4 ATM	2.26e-05	3	96	2	22123827
Interaction	KPNA5 interactions	IPO5 HIF1A ARNT KLHL7 ZRANB2 ATM	3.73e-06	89	94	6	int:KPNA5
Cytoband	3q11.2	OR5K2 OR5K1 GABRR3	2.22e-05	26	96	3	3q11.2
Cytoband	5q32	FBXO38 PPARGC1B SPINK9	2.03e-04	54	96	3	5q32
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5K2 OR5K1 GABRR3	2.03e-04	54	96	3	chr3q11
Cytoband	Ensembl 112 genes in cytogenetic band chr5q32	FBXO38 PPARGC1B SPINK9	6.48e-04	80	96	3	chr5q32
Cytoband	15q22	FEM1B HERC1	1.69e-03	29	96	2	15q22
GeneFamily	Argonaute/PIWI family	PIWIL1 PIWIL4 PIWIL3	2.69e-06	8	67	3	408
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	ZMYND11 HIF1A PPP2R5C DST DBF4 ARNT2 APC LHFPL2 UTP20 ZZEF1 YY1 BTRC PHF21A DOP1B	2.48e-06	856	95	14	M4500
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	ZNF10 PPP2R5C ASH1L AAK1 RNF213 ATM HERC1 CEMIP2	9.14e-09	192	96	8	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	ZNF10 PPP2R5C AAK1 RNF213 ATM HERC1 CEMIP2	4.84e-08	156	96	7	1545169694f686d28648a68b552c2ae606599d66
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PPP2R5C ASH1L ZRANB2 AAK1 RNF213 ATM HERC1	2.55e-07	199	96	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	SLC32A1 DST CADPS ARNT2 WLS CDK14 CEMIP2	2.63e-07	200	96	7	c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	PPP2R5C ASH1L ZRANB2 AAK1 RNF213 CEMIP2	7.99e-07	147	96	6	94998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	PPP2R5C AAK1 RNF213 ATM HERC1 CEMIP2	1.93e-06	171	96	6	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	ZNF10 ASH1L AAK1 RNF213 ATM HERC1	2.68e-06	181	96	6	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	SLC32A1 ARNT2 AAK1 APC WLS CRHBP	3.99e-06	194	96	6	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	SLC32A1 ARNT2 AAK1 APC WLS CRHBP	3.99e-06	194	96	6	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	T/NK_cells-CD8+_Naive_T_cell\|World / Lineage and Cell class	JAK1 PPP2R5C AAK1 RNF213 ATM CEMIP2	4.11e-06	195	96	6	43f11068beea076e9caeb1572215c3f65c9308e1
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PPP2R5C ZRANB2 AAK1 RNF213 ATM HERC1	4.36e-06	197	96	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Severe_COVID-19\|World / Disease group,lineage and cell class （2021.01.30）	FNIP2 HIF1A OTOF LHFPL2 RNF213 GCH1	4.49e-06	198	96	6	09fd456077bb3a657ad3b10c6cfe799b7266456a
ToppCell	BAL-Severe\|BAL / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 HIF1A OTOF LHFPL2 RNF213 GCH1	4.49e-06	198	96	6	454aee3f4fe6d0beeccc55200b4495f4f9b44feb
ToppCell	BAL-Severe\|BAL / Location, Disease Group, Cell group, Cell class (2021.03.09)	FNIP2 HIF1A OTOF LHFPL2 RNF213 GCH1	4.49e-06	198	96	6	687f69c16343227854c882b4a0f3930ce534a3d2
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac1_Htr1d\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC32A1 TMEM44 LUZP2 RXFP3 CRHBP	2.16e-05	155	96	5	79264ff283e36a059040a5aa9fe7337be694cb52
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC32A1 TMEM44 RXFP3 SMC2 CRHBP	2.59e-05	161	96	5	dccb61d5e17a8f1c6d1fc146ee389f567659a0f0
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ZNF10 SLC32A1 PI4KA PABPN1L SLC1A4	3.86e-05	175	96	5	37c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTHFD1L DBF4 SERPINC1 CCNJ SMC2	4.65e-05	182	96	5	11494a66d986297b837332ee9d382b71b9f22591
ToppCell	NS-moderate-d_07-13-Myeloid-Monocyte-derived_Macrophage\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLT1 IDI2-AS1 LHFPL2 RNF213 GCH1	4.65e-05	182	96	5	e03e995e5fd14fc6a7559b83c0ca4e7ccc8e3d0f
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMK+-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	JAK1 PPP2R5C RNF213 ATM CEMIP2	4.77e-05	183	96	5	79defd22b3194dad16db55b9bdd220c09c1e6b90
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC32A1 LUZP2 RXFP3 WLS CRHBP	4.90e-05	184	96	5	c4c1a3d279ca733b865ce46570d7642dc137f9a4
ToppCell	LPS_only\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HIF1A MTHFD1L RNF213 GCH1 CEMIP2	5.03e-05	185	96	5	a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CNOT11 R3HCC1L RNF213 ZZEF1 PHF21A	5.29e-05	187	96	5	4527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ZNF10 ASH1L RNF213 HERC1 CEMIP2	5.43e-05	188	96	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	JAK1 PPP2R5C RNF213 ATM CEMIP2	5.85e-05	191	96	5	753deb090b7b78b4ef31604dbe5dbfc4dcf5184a
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	JAK1 PPP2R5C RNF213 ATM CEMIP2	5.85e-05	191	96	5	355f5bcb220d917163833dead0050fc756c7b260
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	JAK1 PPP2R5C RNF213 ATM CEMIP2	5.85e-05	191	96	5	337d7d7b89fe370e1fe005b9daad76c5dc3b8444
ToppCell	P03-Endothelial-large_vessel_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT1 DST TMEM44 GCH1 CEMIP2	5.85e-05	191	96	5	b680e0c35f1004be36f9f0680ae3c62952e2b607
ToppCell	control-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ZRANB2 AAK1 RNF213 MYSM1 CDC7	6.14e-05	193	96	5	89d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-SST-MGE1-4\|World / Primary Cells by Cluster	SLC32A1 DST AAK1 WLS CEMIP2	6.14e-05	193	96	5	2eb6e4cff4fe3ce564c1581f6f7df4834895aaa9
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC32A1 OTOF AAK1 WLS CRHBP	6.14e-05	193	96	5	2189da4b727e25e62669d7b9257f06493be21a27
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZRANB2 AAK1 RNF213 ATM HERC1	6.14e-05	193	96	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	3'_v3-bone_marrow-Lymphocytic_NK-NK_CD16\|bone_marrow / Manually curated celltypes from each tissue	JAK1 PPP2R5C RNF213 ATM CEMIP2	6.30e-05	194	96	5	7773501e076d470158dbc1d7f10c67152b326eb7
ToppCell	control-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ZRANB2 AAK1 RNF213 CEMIP2 CCDC152	6.45e-05	195	96	5	66959ae839eb60a573da06bdd227090ebb5bb9ed
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	FLT1 TMEM44 LHFPL2 HERC1 CRHBP	6.61e-05	196	96	5	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	moderate-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PPP2R5C ZRANB2 AAK1 RNF213 CEMIP2	6.61e-05	196	96	5	9152f4a8a27ff4ee28f231c5ad00eb2edd9ea6da
ToppCell	Severe\|World / Condition, Lineage, Cell class and cell subclass	FNIP2 HIF1A LHFPL2 RNF213 GCH1	7.10e-05	199	96	5	a8b87f4f504a3b0ad6013277f0c9f543db3ef1fb
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	JAK1 FLT1 HIF1A RNF213 BCR	7.27e-05	200	96	5	6f531a418ff25b59a543800cf4bce7b72404ce08
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	JAK1 FLT1 HIF1A RNF213 CEMIP2	7.27e-05	200	96	5	2d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	FLT1 HIF1A RNF213 BCR CEMIP2	7.27e-05	200	96	5	edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	JAK1 PPP2R5C AAK1 RNF213 ATM	7.27e-05	200	96	5	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	Neuronal-Inhibitory-iB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC32A1 CADPS AAK1 WLS CRHBP	7.27e-05	200	96	5	45ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	ASH1L RNF213 ATM CEMIP2	1.37e-04	121	96	4	19333a660800b583fa27b495c1f7828e6636a257
Disease	endometrial cancer (is_implicated_in)	JAK1 SHBG APC ATM	5.26e-06	36	94	4	DOID:1380 (is_implicated_in)
Disease	Transitional cell carcinoma of bladder	FLT1 BCR	6.00e-05	4	94	2	C0279680
Disease	severe acute respiratory syndrome, COVID-19	AXDND1 CADPS MTHFD1L ARNT2 SYT14 NMBR OR5K1 TG	9.30e-05	447	94	8	EFO_0000694, MONDO_0100096
Disease	mental or behavioural disorder, substance abuse	LUZP2 CDC7	1.49e-04	6	94	2	EFO_0000677, MONDO_0002491
Disease	disease of cellular proliferation (implicated_via_orthology)	JAK1 ATM	2.09e-04	7	94	2	DOID:14566 (implicated_via_orthology)
Disease	estradiol measurement	JAK1 PPARGC1B PIWIL1 SHBG	4.31e-04	110	94	4	EFO_0004697
Disease	Malignant neoplasm of breast	GPR180 PPARGC1B SLC39A12 FLT1 ADHFE1 HIF1A OTOF ZNF432 UTP20 ATM NMBR	6.18e-04	1074	94	11	C0006142
Disease	Oligospermia	PIWIL4 PIWIL3	6.49e-04	12	94	2	C0028960
Disease	Myeloproliferative disease	ATG2B BCR	6.49e-04	12	94	2	C0027022
Disease	macular retinal edema (is_marker_for)	FLT1 HIF1A	6.49e-04	12	94	2	DOID:4449 (is_marker_for)
Disease	drug use measurement, depressive symptom measurement, SSRI use measurement	LUZP2 CSMD2	7.65e-04	13	94	2	EFO_0007006, EFO_0007010, EFO_0007011
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	JAK1 ARNT BCR	9.86e-04	61	94	3	C1961102
Disease	preeclampsia, parental genotype effect measurement	FLT1 WLS	1.17e-03	16	94	2	EFO_0000668, EFO_0005939
Disease	Neoplasms, Experimental	HIF1A ARNT BCR	1.24e-03	66	94	3	C0027659
Disease	Benign neoplasm of stomach	APC ATM	1.32e-03	17	94	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	APC ATM	1.32e-03	17	94	2	C0496905
Disease	Lipidemias	PPARGC1B APC	1.32e-03	17	94	2	C1706412
Disease	Carcinoma in situ of stomach	APC ATM	1.32e-03	17	94	2	C0154060
Disease	Hyperlipidemia	PPARGC1B APC	1.32e-03	17	94	2	C0020473
Disease	age at onset, Parkinson disease	AAK1 LHFPL2	1.49e-03	18	94	2	EFO_0004847, MONDO_0005180
Disease	stomach cancer (is_implicated_in)	JAK1 APC ATP4B	1.59e-03	72	94	3	DOID:10534 (is_implicated_in)
Disease	leukemia (implicated_via_orthology)	ASH1L ATM	1.66e-03	19	94	2	DOID:1240 (implicated_via_orthology)
Disease	FEV/FEC ratio	PPARGC1B FLT1 DST KLHL7 CADPS LHFPL2 HERC1 NMBR YY1 CEMIP2 TG	1.82e-03	1228	94	11	EFO_0004713
Disease	Stomach Carcinoma	APC ATM	2.03e-03	21	94	2	C0699791
Disease	Immunologic Deficiency Syndromes	ATM MYSM1	2.43e-03	23	94	2	C0021051
Disease	Intellectual Disability	ZMYND11 ASH1L APC YY1 SLC1A4 PHF21A	3.10e-03	447	94	6	C3714756
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	APC ATM	3.10e-03	26	94	2	C0009405
Disease	Micronuclei, Chromosome-Defective	HIF1A PPP2R5C	3.10e-03	26	94	2	C1449861
Disease	Micronuclei, Genotoxicant-Induced	HIF1A PPP2R5C	3.10e-03	26	94	2	C1449862
Disease	nevus count, cutaneous melanoma	PPARGC1B ARNT ATM	3.11e-03	91	94	3	EFO_0000389, EFO_0004632

Protein segments in the cluster

Peptide	Gene	Start	Entry
SMGKALEMSCAIQNQ	BARGIN	101	Q6ZT62
TGTVKKEGQQSSMRM	ARNT	241	P27540
KMKVCAMEQAEGTPR	PABPN1L	91	A6NDY0
RQGSMIQTLAMKKAS	ASH1L	1141	Q9NR48
IRTQGQKKVASMMES	CFAP43	1476	Q8NDM7
AGSLQKSTEVMKAMQ	CHMP3	101	Q9Y3E7
QGSKRITCMKVSDMF	CSMD2	376	Q7Z408
SNGMKCALKRMFVNN	AAK1	66	Q2M2I8
SSLGSQAMQMERKKS	BCR	201	P11274
FNNGMMVTCSKDRSI	BTRC	391	Q9Y297
QALKKQVVMQAMGSC	CCDC96	331	Q2M329
SLGCMTNMNLVLTKQ	CCNJ	111	Q5T5M9
MLTCNKAGSRMVVDA	PPP2R5C	1	Q13362
EICVTKMSTRNCQGM	CDK14	41	O94921
KMSTRNCQGMDSVIK	CDK14	46	O94921
MTKLGACNDTLQQLM	SERPINC1	121	P01008
MAALQEKKTCGQRME	ATP4B	1	P51164
LQCLFQRKGSMTMSI	MTHFD1L	236	Q6UB35
LNEKMSNKCSMLSTA	DBF4	426	Q9UBU7
MTSSMQLAKECLSQK	ATG2B	121	Q96BY7
AQTRAMKQVAGTMKL	ATP5F1A	421	P25705
GTVKKEGQQSSMRMC	ARNT2	216	Q9HBZ2
KNVGDITNKACMMDT	R3HCC1L	366	Q7Z5L2
MSKKLCIQMTTGAFI	OR5K2	136	Q8NHB8
NAMAFCAKMRSSKKT	JAK1	11	P23458
MVDAKAQSTKLCSME	CADPS	1141	Q9ULU8
MQTSGALLRTCVKAM	NMBR	151	P28336
ATKENMTSQRGMLKS	GOSR1	186	O95249
QEMLNMSKKTVSCFV	HAUS2	31	Q9NVX0
TMFSIECAKQTKQMV	SPINK9	16	Q5DT21
ANKTCKMMLATEETS	DST	5231	Q03001
MKCTLTSRGRTMNIK	HIF1A	171	Q16665
MMQLVSVAKSSEGKN	DOP1B	1356	Q9Y3R5
SLLTAKQLEQMVCGM	HERC1	4716	Q15751
QICSTKGMMAGAEKL	DDX58	141	O95786
TQMKMSLKCLAARAV	FEM1B	591	Q9UK73
VMETGNTKNSALMAK	PLRG1	166	O43660
QMSVIGSRKKSVNMT	MEX3D	166	Q86XN8
SNSISKCMEMKNTIL	PHF21A	591	Q96BD5
QKDKSGMMQCVIAVA	PI4KA	926	P42356
MDCGNKARTVAATNM	KIF1C	196	O43896
TMCVQSIMKKSIFNV	LHFPL2	121	Q6ZUX7
MGVMNNMRKQKTLCD	KLHL7	31	Q8IXQ5
CSEKLSKAQLTMTMN	GPR180	91	Q86V85
IIQMETQSSMRKKVC	IPO5	96	O00410
MSKKLCIQMTTGAFI	OR5K1	136	Q8NHB7
MGPRKKSVKTCIMNN	FBXO38	1	Q6PIJ6
ILVSLTMKNCKAAMN	ATM	611	Q13315
NTRGTRVKCMANEVM	CEFIP	921	Q711Q0
NIKMTHQRCSSSMKQ	GABRR3	26	A8MPY1
AQMKVGCDNTVVRMV	CRHBP	271	P24387
KVMNSAVMRKTASSC	CDC7	331	O00311
LTMMSGTLEKNQLCQ	FNIP2	401	Q9P278
CKGMVTAMALSKSTN	AXDND1	766	Q5T1B0
CMAMVRKSSALGKEV	IDI2-AS1	26	Q9NZ38
AVSQITRMCLLKGNM	DDX50	616	Q9BQ39
MDQSSEGCMKKISSV	CCDC152	1	Q4G0S7
NNSMCTTMRDKVFGN	CEMIP2	636	Q9UHN6
SQMKAMKETVQLCLT	LUZP2	201	Q86TE4
MKSDCMQTTICQERK	DUS4L	1	O95620
QFKCSSSKARQLMMT	EVC	331	P57679
KALKSECQGQMERQM	CCDC158	436	Q5M9N0
TIVTKIAQQMNCKMG	PIWIL3	621	Q7Z3Z3
EMPIGSMTASNRKCK	SLC39A12	521	Q504Y0
RGAKTAKQCTMEMAT	OTOF	1856	Q9HC10
SMKKLMACVSQDNFS	PRM3	31	Q9NNZ6
MGAKNVCLMTDKNLS	ADHFE1	71	Q8IWW8
ATKIALQMNCKMGGE	PIWIL1	601	Q96J94
GKAMCKIVSMVTSMN	RXFP3	151	Q9NSD7
NDDSATCKKMASMTI	UTP20	2336	O75691
SQSTESNMSVPKKMC	SENP7	916	Q9BQF6
RKQSEMQMKAGVTCE	PSAPL1	281	Q6NUJ1
KLTLLNSMGQEMSKC	SYT14	456	Q8NB59
NSMGQEMSKCKTSIR	SYT14	461	Q8NB59
SRICATVKKTMNMIQ	SKA2	76	Q8WVK7
RGVQKMNSKTVTSTM	GCH1	216	P30793
CVLARTLNKQGMMMS	PIWIL4	576	Q7Z3Z4
IATKIAMQMTCKLGG	PIWIL4	591	Q7Z3Z4
KKAPMMQSQSRSCTE	PPARGC1B	201	Q86YN6
SMSRVVLSQGSKMKA	SHBG	311	P04278
SKRDSIEMSMKGCQT	SLC3A1	6	Q07837
SMKGCMRALVAQLKS	APC	521	P25054
MCVKNSTGVEIKRIM	CNOT11	316	Q9UKZ1
NINRVKICMETGKMV	RNF213	3086	Q63HN8
LTEMMERCKKLGNNA	VPS35L	411	Q7Z3J2
SMMKCIEENNGVDKR	SLC1A4	351	P43007
MSRQANRGTESKKMS	TRAPPC3	1	O43617
KGCTKMFRDNSAMRK	YY1	301	P25490
FLSCVMKSKMRQALG	TMEM44	311	Q2T9K0
QGMTKVTTDKMAQER	PLCB2	1056	Q00722
QMMACKNDISKAQTE	SMC2	401	O95347
CNRCGREKTTEAKMM	ZRANB2	31	O95218
NIRAGNKMIVMETCA	TRMT6	196	Q9UJA5
KQSCDIKMEGMARND	ZNF10	106	P21506
AVANMQGEMDRKCKQ	ZMYND11	516	Q15326
NECGKGFTMKSRMIE	ZNF432	376	O94892
CMALKSVRQLGSNMV	ZZEF1	1221	O43149
SSKCMMKEVLSTGQG	ZNF611	66	Q8N823
VSNKSQAKMSGMFAR	SLC32A1	16	Q9H598
MAGAIIENMSTKKLC	WLS	1	Q5T9L3
TQRMAIIEGKNKMAS	FLT1	506	P17948
DCEKQRARMQSLMGS	TG	661	P01266
MRKTLSKVTNCFMAE	MYSM1	781	Q5VVJ2