Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR2 ITPR3	7.94e-06	3	33	2	GO:0005220
GeneOntologyMolecularFunction	tRNA (cytidine-3-)-methyltransferase activity	METTL2A METTL2B	1.59e-05	4	33	2	GO:0052735
GeneOntologyMolecularFunction	calcium channel activity	TRPV6 TRPM7 ITPR2 ITPR3	5.88e-05	129	33	4	GO:0005262
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPV6 TRPM7 ITPR2 ITPR3	1.08e-04	151	33	4	GO:0015085
GeneOntologyMolecularFunction	tRNA (cytidine) methyltransferase activity	METTL2A METTL2B	1.18e-04	10	33	2	GO:0016427
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	ITPR2 ITPR3	2.38e-04	14	33	2	GO:0070679
GeneOntologyMolecularFunction	diacylglycerol binding	UNC13B UNC13A	3.13e-04	16	33	2	GO:0019992
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	ITPR2 ITPR3	3.99e-04	18	33	2	GO:0015278
GeneOntologyMolecularFunction	syntaxin-1 binding	UNC13B UNC13A	7.15e-04	24	33	2	GO:0017075
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	ITPR2 ITPR3	1.20e-03	31	33	2	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	ITPR2 ITPR3	1.35e-03	33	33	2	GO:0005217
GeneOntologyMolecularFunction	tRNA methyltransferase activity	METTL2A METTL2B	1.44e-03	34	33	2	GO:0008175
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPV6 TRPM7 ITPR2 ITPR3	2.36e-03	343	33	4	GO:0005261
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	ARMT1 METTL2A METTL2B	2.83e-03	172	33	3	GO:0008757
GeneOntologyMolecularFunction	methyltransferase activity	ARMT1 METTL2A METTL2B	5.16e-03	213	33	3	GO:0008168
GeneOntologyMolecularFunction	RNA methyltransferase activity	METTL2A METTL2B	5.48e-03	67	33	2	GO:0008173
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	ARMT1 METTL2A METTL2B	5.93e-03	224	33	3	GO:0016741
GeneOntologyMolecularFunction	calmodulin binding	UNC13B TRPV6 UNC13A	6.38e-03	230	33	3	GO:0005516
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPV6 TRPM7 ITPR2 ITPR3	6.65e-03	459	33	4	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPV6 TRPM7 ITPR2 ITPR3	6.96e-03	465	33	4	GO:0046873
GeneOntologyMolecularFunction	myosin binding	ARFGEF1 TRPM7	8.68e-03	85	33	2	GO:0017022
GeneOntologyMolecularFunction	syntaxin binding	UNC13B UNC13A	9.08e-03	87	33	2	GO:0019905
GeneOntologyMolecularFunction	channel activity	TRPV6 TRPM7 ITPR2 ITPR3	1.06e-02	525	33	4	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TRPV6 TRPM7 ITPR2 ITPR3	1.06e-02	526	33	4	GO:0022803
GeneOntologyMolecularFunction	phospholipid binding	UNC13B UNC13A ITPR2 ITPR3	1.22e-02	548	33	4	GO:0005543
GeneOntologyMolecularFunction	alcohol binding	ITPR2 ITPR3	1.23e-02	102	33	2	GO:0043178
GeneOntologyBiologicalProcess	dense core granule docking	UNC13B UNC13A	2.64e-06	2	34	2	GO:0061790
GeneOntologyBiologicalProcess	dense core granule priming	UNC13B UNC13A	1.58e-05	4	34	2	GO:0061789
GeneOntologyBiologicalProcess	presynaptic dense core vesicle exocytosis	UNC13B UNC13A	1.18e-04	10	34	2	GO:0099525
GeneOntologyBiologicalProcess	formation of translation preinitiation complex	MCTS2 MCTS1	1.18e-04	10	34	2	GO:0001731
GeneOntologyBiologicalProcess	neuronal dense core vesicle exocytosis	UNC13B UNC13A	1.72e-04	12	34	2	GO:0099011
GeneOntologyBiologicalProcess	regulation of synaptic vesicle priming	UNC13B UNC13A	2.37e-04	14	34	2	GO:0010807
GeneOntologyBiologicalProcess	dense core granule exocytosis	UNC13B UNC13A	2.73e-04	15	34	2	GO:1990504
GeneOntologyBiologicalProcess	calcium-ion regulated exocytosis	UNC13B TRPV6 UNC13A	3.32e-04	82	34	3	GO:0017156
GeneOntologyBiologicalProcess	synaptic vesicle docking	UNC13B UNC13A	3.53e-04	17	34	2	GO:0016081
GeneOntologyBiologicalProcess	regulation of short-term neuronal synaptic plasticity	UNC13B UNC13A	5.97e-04	22	34	2	GO:0048172
GeneOntologyBiologicalProcess	calcium ion-regulated exocytosis of neurotransmitter	UNC13B UNC13A	7.73e-04	25	34	2	GO:0048791
GeneOntologyBiologicalProcess	protein tetramerization	TRPV6 TRPM7 ITPR3	8.47e-04	113	34	3	GO:0051262
GeneOntologyBiologicalProcess	dense core granule localization	UNC13B UNC13A	9.71e-04	28	34	2	GO:0032253
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR2 ITPR3	9.73e-05	9	35	2	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ITPR2 ITPR3	1.48e-04	11	35	2	GO:0031094
GeneOntologyCellularComponent	presynaptic active zone cytoplasmic component	UNC13B UNC13A	6.74e-04	23	35	2	GO:0098831
GeneOntologyCellularComponent	nuclear matrix	ARFGEF1 PBRM1 STAG2	1.64e-03	140	35	3	GO:0016363
GeneOntologyCellularComponent	calyx of Held	UNC13B UNC13A	1.66e-03	36	35	2	GO:0044305
GeneOntologyCellularComponent	nuclear outer membrane	SMPD4 ITPR3	2.04e-03	40	35	2	GO:0005640
GeneOntologyCellularComponent	brush border	SI TMPRSS15 ITPR3	2.08e-03	152	35	3	GO:0005903
GeneOntologyCellularComponent	T cell receptor complex	TRBV4-3 TRBV4-2 TRBV3-1	2.54e-03	163	35	3	GO:0042101
GeneOntologyCellularComponent	cell cortex region	UNC13B UNC13A	2.58e-03	45	35	2	GO:0099738
GeneOntologyCellularComponent	receptor complex	TRBV4-3 TRBV4-2 TRBV3-1 ITPR2 ITPR3	2.65e-03	581	35	5	GO:0043235
GeneOntologyCellularComponent	nuclear periphery	ARFGEF1 PBRM1 STAG2	2.90e-03	171	35	3	GO:0034399
GeneOntologyCellularComponent	exocytic vesicle membrane	UNC13B TRPM7 UNC13A	3.30e-03	179	35	3	GO:0099501
GeneOntologyCellularComponent	synaptic vesicle membrane	UNC13B TRPM7 UNC13A	3.30e-03	179	35	3	GO:0030672
MousePheno	low sweet preference	SI ITPR3	1.84e-05	4	25	2	MP:0012347
Domain	InsP3_rcpt-bd	ITPR2 ITPR3	8.52e-06	3	32	2	IPR000493
Domain	Unc-13	UNC13B UNC13A	8.52e-06	3	32	2	IPR027080
Domain	MeTrfase	METTL2A METTL2B	1.70e-05	4	32	2	IPR026113
Domain	Munc13_dom-2	UNC13B UNC13A	2.83e-05	5	32	2	IPR014772
Domain	Membr_traf_MHD	UNC13B UNC13A	2.83e-05	5	32	2	PF10540
Domain	DUF1041	UNC13B UNC13A	2.83e-05	5	32	2	SM01145
Domain	MHD2	UNC13B UNC13A	2.83e-05	5	32	2	PS51259
Domain	Munc13_subgr_dom-2	UNC13B UNC13A	2.83e-05	5	32	2	IPR019558
Domain	Ion_trans_dom	TRPV6 TRPM7 ITPR2 ITPR3	4.15e-05	114	32	4	IPR005821
Domain	Ion_trans	TRPV6 TRPM7 ITPR2 ITPR3	4.15e-05	114	32	4	PF00520
Domain	Methyltransf_12	METTL2A METTL2B	4.25e-05	6	32	2	PF08242
Domain	RIH_assoc	ITPR2 ITPR3	4.25e-05	6	32	2	PF08454
Domain	RIH_assoc-dom	ITPR2 ITPR3	4.25e-05	6	32	2	IPR013662
Domain	RYDR_ITPR	ITPR2 ITPR3	4.25e-05	6	32	2	PF01365
Domain	RIH_dom	ITPR2 ITPR3	4.25e-05	6	32	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR2 ITPR3	4.25e-05	6	32	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR2 ITPR3	4.25e-05	6	32	2	IPR015925
Domain	Ins145_P3_rec	ITPR2 ITPR3	4.25e-05	6	32	2	PF08709
Domain	Methyltransf_12	METTL2A METTL2B	4.25e-05	6	32	2	IPR013217
Domain	-	ITPR2 ITPR3	4.25e-05	6	32	2	1.25.10.30
Domain	DUF1041	UNC13B UNC13A	5.94e-05	7	32	2	PF06292
Domain	Munc13_1	UNC13B UNC13A	5.94e-05	7	32	2	IPR014770
Domain	CAPS_dom	UNC13B UNC13A	5.94e-05	7	32	2	IPR010439
Domain	MHD1	UNC13B UNC13A	5.94e-05	7	32	2	PS51258
Domain	MIR	ITPR2 ITPR3	1.27e-04	10	32	2	PS50919
Domain	MIR	ITPR2 ITPR3	1.27e-04	10	32	2	PF02815
Domain	MIR	ITPR2 ITPR3	1.27e-04	10	32	2	SM00472
Domain	MIR_motif	ITPR2 ITPR3	1.27e-04	10	32	2	IPR016093
Domain	ZnF_U1	ZFHX3 ZFHX4	1.12e-03	29	32	2	SM00451
Domain	Znf_U1	ZFHX3 ZFHX4	1.12e-03	29	32	2	IPR003604
Domain	C1Q	C1QTNF8 C1QTNF6	1.37e-03	32	32	2	SM00110
Domain	C1q	C1QTNF8 C1QTNF6	1.37e-03	32	32	2	PF00386
Domain	C1q_dom	C1QTNF8 C1QTNF6	1.54e-03	34	32	2	IPR001073
Domain	C1Q	C1QTNF8 C1QTNF6	1.54e-03	34	32	2	PS50871
Domain	ARM-type_fold	ARFGEF1 UTP20 STAG2 ITPR2	2.57e-03	339	32	4	IPR016024
Domain	-	C1QTNF8 C1QTNF6	3.31e-03	50	32	2	2.60.120.40
Domain	C1_1	UNC13B UNC13A	4.28e-03	57	32	2	PF00130
Domain	Tumour_necrosis_fac-like_dom	C1QTNF8 C1QTNF6	4.43e-03	58	32	2	IPR008983
Domain	ZF_DAG_PE_1	UNC13B UNC13A	5.37e-03	64	32	2	PS00479
Domain	ZF_DAG_PE_2	UNC13B UNC13A	5.37e-03	64	32	2	PS50081
Domain	C1	UNC13B UNC13A	5.53e-03	65	32	2	SM00109
Domain	-	ZFHX3 ZNF112 ZFHX4 ZNF653 ZNF507	5.58e-03	679	32	5	3.30.160.60
Domain	PE/DAG-bd	UNC13B UNC13A	5.70e-03	66	32	2	IPR002219
Domain	zf-C2H2	ZFHX3 ZNF112 ZFHX4 ZNF653 ZNF507	6.08e-03	693	32	5	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZFHX3 ZNF112 ZFHX4 ZNF653 ZNF507	6.12e-03	694	32	5	IPR013087
Domain	Collagen	C1QTNF8 C1QTNF6	9.29e-03	85	32	2	PF01391
Domain	Collagen	C1QTNF8 C1QTNF6	9.29e-03	85	32	2	IPR008160
Domain	ZINC_FINGER_C2H2_2	ZFHX3 ZNF112 ZFHX4 ZNF653 ZNF507	9.64e-03	775	32	5	PS50157
Domain	ZINC_FINGER_C2H2_1	ZFHX3 ZNF112 ZFHX4 ZNF653 ZNF507	9.74e-03	777	32	5	PS00028
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR2 ITPR3	2.77e-05	5	24	2	M49000
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	4.15e-05	6	24	2	M47960
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	9.93e-05	9	24	2	M47852
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR2 ITPR3	1.24e-04	10	24	2	M47661
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR2 ITPR3	1.51e-04	11	24	2	M49033
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	ITPR2 ITPR3	1.51e-04	11	24	2	M27466
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	2.14e-04	13	24	2	M47751
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR2 ITPR3	2.14e-04	13	24	2	M47656
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	2.14e-04	13	24	2	M47696
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR2 ITPR3	2.14e-04	13	24	2	MM14553
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR2 ITPR3	3.29e-04	16	24	2	M26945
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	4.67e-04	19	24	2	M47760
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	ITPR2 ITPR3	4.67e-04	19	24	2	M27423
Pathway	KEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	4.67e-04	19	24	2	M47733
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	5.18e-04	20	24	2	M47688
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	5.72e-04	21	24	2	M47689
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	6.28e-04	22	24	2	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	6.28e-04	22	24	2	M47675
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	6.88e-04	23	24	2	M47676
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR2 ITPR3	8.14e-04	25	24	2	MM14511
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR2 ITPR3	9.50e-04	27	24	2	M12123
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR2 ITPR3	9.50e-04	27	24	2	MM15053
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR2 ITPR3	1.02e-03	28	24	2	M924
Pathway	REACTOME_TRP_CHANNELS	TRPV6 TRPM7	1.02e-03	28	24	2	MM14943
Pathway	REACTOME_TRP_CHANNELS	TRPV6 TRPM7	1.02e-03	28	24	2	M27241
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	ITPR2 ITPR3	1.34e-03	32	24	2	MM14983
Pathway	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	ITPR2 ITPR3	1.69e-03	36	24	2	M1315
Pathway	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION	ITPR2 ITPR3	1.69e-03	36	24	2	M39831
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	ITPR2 ITPR3	2.19e-03	41	24	2	M512
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	ITPR2 ITPR3	2.29e-03	42	24	2	M791
Pathway	WP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS	ITPR2 ITPR3	2.52e-03	44	24	2	M39845
Pathway	SIG_CHEMOTAXIS	ITPR2 ITPR3	2.63e-03	45	24	2	M5193
Pathway	SIG_BCR_SIGNALING_PATHWAY	ITPR2 ITPR3	2.75e-03	46	24	2	M8626
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	3.24e-03	50	24	2	M47951
Pathway	WP_SYNAPTIC_VESICLE_PATHWAY	UNC13B UNC13A	3.37e-03	51	24	2	M39457
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	ITPR2 ITPR3	3.63e-03	53	24	2	MM15716
Pathway	REACTOME_ION_HOMEOSTASIS	ITPR2 ITPR3	3.77e-03	54	24	2	MM15202
Pathway	REACTOME_ION_HOMEOSTASIS	ITPR2 ITPR3	3.77e-03	54	24	2	M27460
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ITPR2 ITPR3	3.77e-03	54	24	2	M26911
Pathway	KEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	3.90e-03	55	24	2	M47952
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ITPR2 ITPR3	4.78e-03	61	24	2	MM15071
Pathway	REACTOME_CA2_PATHWAY	ITPR2 ITPR3	4.94e-03	62	24	2	M27321
Pathway	KEGG_LONG_TERM_POTENTIATION	ITPR2 ITPR3	6.25e-03	70	24	2	M3115
Pathway	KEGG_LONG_TERM_DEPRESSION	ITPR2 ITPR3	6.25e-03	70	24	2	M8232
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	ITPR2 ITPR3	6.60e-03	72	24	2	MM14631
Pathway	WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY	ITPR2 ITPR3	6.96e-03	74	24	2	M48080
Pathway	WP_ALZHEIMERS_DISEASE	ITPR2 ITPR3	6.96e-03	74	24	2	MM15962
Pathway	WP_16P112_PROXIMAL_DELETION_SYNDROME	UNC13B UNC13A	7.33e-03	76	24	2	M40057
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	ITPR2 ITPR3	7.33e-03	76	24	2	M9052
Pathway	REACTOME_PLATELET_HOMEOSTASIS	ITPR2 ITPR3	7.33e-03	76	24	2	MM15051
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ITPR2 ITPR3	7.71e-03	78	24	2	M1921
Pubmed	A genetically determined insertion/deletion related polymorphism in human T cell receptor beta chain (TCRB) includes functional variable gene segments.	TRBV4-3 TRBV4-2 TRBV3-1	1.02e-08	5	36	3	7931073
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	TRPV6 TRPM7 ITPR2 ITPR3	6.96e-08	38	36	4	30786075
Pubmed	Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.	UNC13B UNC13A	1.04e-06	2	36	2	31851910
Pubmed	Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.	ITPR2 ITPR3	1.04e-06	2	36	2	33854148
Pubmed	Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.	ITPR2 ITPR3	1.04e-06	2	36	2	15713744
Pubmed	Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.	UNC13B UNC13A	1.04e-06	2	36	2	28426965
Pubmed	Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.	ITPR2 ITPR3	1.04e-06	2	36	2	9065779
Pubmed	The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers.	ZFHX3 ZFHX4	1.04e-06	2	36	2	10873665
Pubmed	Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.	UNC13B UNC13A	1.04e-06	2	36	2	28489077
Pubmed	Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.	ITPR2 ITPR3	1.04e-06	2	36	2	17496801
Pubmed	IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.	ITPR2 ITPR3	1.04e-06	2	36	2	16195467
Pubmed	A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.	UNC13B UNC13A	1.04e-06	2	36	2	35613050
Pubmed	Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.	ITPR2 ITPR3	1.04e-06	2	36	2	19528657
Pubmed	Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.	UNC13B UNC13A	1.04e-06	2	36	2	11832228
Pubmed	Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.	UNC13B UNC13A	1.04e-06	2	36	2	23770256
Pubmed	Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.	UNC13B UNC13A	1.04e-06	2	36	2	10440375
Pubmed	Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.	UNC13B UNC13A	1.04e-06	2	36	2	22066784
Pubmed	Membrane bridging by Munc13-1 is crucial for neurotransmitter release.	UNC13B UNC13A	1.04e-06	2	36	2	30816091
Pubmed	Munc13 controls the location and efficiency of dense-core vesicle release in neurons.	UNC13B UNC13A	1.04e-06	2	36	2	23229896
Pubmed	Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.	UNC13B UNC13A	1.04e-06	2	36	2	32187536
Pubmed	Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.	ITPR2 ITPR3	1.04e-06	2	36	2	8063813
Pubmed	Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.	UNC13B UNC13A	1.04e-06	2	36	2	12070347
Pubmed	Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.	UNC13B UNC13A	1.04e-06	2	36	2	11792326
Pubmed	Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.	UNC13B UNC13A	1.04e-06	2	36	2	28772123
Pubmed	Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	1.04e-06	2	36	2	8081734
Pubmed	A common molecular basis for membrane docking and functional priming of synaptic vesicles.	UNC13B UNC13A	1.04e-06	2	36	2	19558619
Pubmed	Regulation of insulin exocytosis by Munc13-1.	UNC13B UNC13A	1.04e-06	2	36	2	12871971
Pubmed	Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.	UNC13B UNC13A	1.04e-06	2	36	2	18701688
Pubmed	Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.	ITPR2 ITPR3	1.04e-06	2	36	2	24901844
Pubmed	Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.	UNC13B UNC13A	1.04e-06	2	36	2	17267576
Pubmed	Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.	UNC13B UNC13A	1.04e-06	2	36	2	17561838
Pubmed	Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.	ITPR2 ITPR3	1.04e-06	2	36	2	15632133
Pubmed	Transcription factor ZFHX3 regulates calcium influx in mammary epithelial cells in part via the TRPV6 calcium channel.	TRPV6 ZFHX3	1.04e-06	2	36	2	31519324
Pubmed	Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.	UNC13B UNC13A	1.04e-06	2	36	2	22814762
Pubmed	Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.	UNC13B UNC13A	1.04e-06	2	36	2	23070049
Pubmed	Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.	ITPR2 ITPR3	3.12e-06	3	36	2	21435446
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR2 ITPR3	3.12e-06	3	36	2	31979185
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR2 ITPR3	3.12e-06	3	36	2	17890015
Pubmed	Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.	UNC13B UNC13A	3.12e-06	3	36	2	33105896
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR2 ITPR3	3.12e-06	3	36	2	10874040
Pubmed	Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.	UNC13B UNC13A	3.12e-06	3	36	2	37343100
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR2 ITPR3	3.12e-06	3	36	2	18547250
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR2 ITPR3	3.12e-06	3	36	2	9808793
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR2 ITPR3	3.12e-06	3	36	2	24904548
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR2 ITPR3	3.12e-06	3	36	2	36350267
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR2 ITPR3	3.12e-06	3	36	2	27777977
Pubmed	The versatility and universality of calcium signalling.	ITPR2 ITPR3	3.12e-06	3	36	2	11413485
Pubmed	Spatiotemporal expression of retrogene-host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells.	MCTS2 MCTS1	3.12e-06	3	36	2	24063864
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR2 ITPR3	3.12e-06	3	36	2	23983250
Pubmed	Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.	UNC13B UNC13A	3.12e-06	3	36	2	17639022
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR2 ITPR3	3.12e-06	3	36	2	20395455
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	3.12e-06	3	36	2	17327232
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR2 ITPR3	3.12e-06	3	36	2	9858485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	3.12e-06	3	36	2	26009177
Pubmed	Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.	UNC13B UNC13A	3.12e-06	3	36	2	22966208
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR2 ITPR3	3.12e-06	3	36	2	17581770
Pubmed	The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.	UNC13B UNC13A	3.12e-06	3	36	2	23658173
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR2 ITPR3	3.12e-06	3	36	2	17437169
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR2 ITPR3	3.12e-06	3	36	2	20427533
Pubmed	TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction.	TRPV6 TRPM7	3.12e-06	3	36	2	29515374
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR2 ITPR3	3.12e-06	3	36	2	18241669
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR2 ITPR3	3.12e-06	3	36	2	16014380
Pubmed	Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.	UNC13B UNC13A	3.12e-06	3	36	2	15988013
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR2 ITPR3	3.12e-06	3	36	2	18194433
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR2 ITPR3	3.12e-06	3	36	2	1693919
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR2 ITPR3	3.12e-06	3	36	2	19068129
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR2 ITPR3	3.12e-06	3	36	2	23955339
Pubmed	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification.	METTL2A METTL2B	3.12e-06	3	36	2	32427860
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR2 ITPR3	6.24e-06	4	36	2	25215520
Pubmed	Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo.	UNC13B UNC13A	6.24e-06	4	36	2	10488064
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR2 ITPR3	6.24e-06	4	36	2	28419336
Pubmed	IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.	ITPR2 ITPR3	6.24e-06	4	36	2	26193638
Pubmed	Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.	UNC13B UNC13A	6.24e-06	4	36	2	19996097
Pubmed	A case-by-case evolutionary analysis of four imprinted retrogenes.	MCTS2 MCTS1	6.24e-06	4	36	2	21166792
Pubmed	Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.	UNC13B UNC13A	6.24e-06	4	36	2	15123597
Pubmed	ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.	UNC13B UNC13A	6.24e-06	4	36	2	28264913
Pubmed	Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6.	METTL2A METTL2B	6.24e-06	4	36	2	34268557
Pubmed	Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins.	METTL2A METTL2B	6.24e-06	4	36	2	11738826
Pubmed	Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.	ITPR2 ITPR3	6.24e-06	4	36	2	17925404
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	6.24e-06	4	36	2	11163362
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR2 ITPR3	6.24e-06	4	36	2	21424589
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR2 ITPR3	6.24e-06	4	36	2	35494252
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR2 ITPR3	6.24e-06	4	36	2	28615414
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR2 ITPR3	6.24e-06	4	36	2	10828023
Pubmed	Behavioral abnormalities observed in Zfhx2-deficient mice.	ZFHX3 ZFHX4	6.24e-06	4	36	2	23300874
Pubmed	Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.	METTL2A METTL2B	1.04e-05	5	36	2	28655767
Pubmed	RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.	UNC13B UNC13A	1.04e-05	5	36	2	22248876
Pubmed	InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.	ITPR2 ITPR3	1.04e-05	5	36	2	21568942
Pubmed	An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.	UNC13B UNC13A	1.04e-05	5	36	2	34706221
Pubmed	A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.	UNC13B UNC13A	1.04e-05	5	36	2	32755572
Pubmed	Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.	UNC13B UNC13A	1.04e-05	5	36	2	33139401
Pubmed	Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors.	ITPR2 ITPR3	1.04e-05	5	36	2	21436055
Pubmed	Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.	UNC13B UNC13A	1.04e-05	5	36	2	26575293
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	ITPR2 ITPR3	1.56e-05	6	36	2	16844763
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	ITPR2 ITPR3	1.56e-05	6	36	2	23463619
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	ITPR2 ITPR3	1.56e-05	6	36	2	20519450
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR2 ITPR3	1.56e-05	6	36	2	21762810
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	ITPR2 ITPR3	1.56e-05	6	36	2	25966694
Pubmed	Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.	UNC13B UNC13A	1.56e-05	6	36	2	28635948
Pubmed	SNAREs and traffic.	UNC13B UNC13A	2.18e-05	7	36	2	15893389
Cytoband	7q34	TRBV4-3 TRBV4-2 TRBV3-1 TRPV6	9.08e-06	167	36	4	7q34
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	TRBV4-2 TRBV3-1 TRPV6	4.17e-04	185	36	3	chr7q34
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR2 ITPR3	5.06e-06	3	24	2	297
GeneFamily	UNC13 homologs	UNC13B UNC13A	1.01e-05	4	24	2	836
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX3 ZFHX4	1.75e-04	15	24	2	529
GeneFamily	T cell receptor beta locus at 7q34	TRBV4-3 TRBV4-2 TRBV3-1	2.02e-04	87	24	3	372
GeneFamily	Endogenous ligands\|C1q and TNF related	C1QTNF8 C1QTNF6	2.55e-04	18	24	2	1372
GeneFamily	Transient receptor potential cation channels	TRPV6 TRPM7	6.25e-04	28	24	2	249
GeneFamily	Methyltransferase like	METTL2A METTL2B	8.70e-04	33	24	2	963
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX3 ZNF112 ZNF653 ZNF507	1.39e-02	718	24	4	28
Drug	adenophostin A	ITPR2 ITPR3	2.16e-06	2	34	2	ctd:C085029
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR2 ITPR3	7.95e-05	12	33	2	DOID:1441 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	ZFHX3 ZFHX4 ITPR2 ITPR3	9.50e-05	215	33	4	DOID:9970 (implicated_via_orthology)
Disease	Amyotrophic Lateral Sclerosis, Guam Form	TRPM7 UNC13A	5.53e-04	31	33	2	C0543859
Disease	amyotrophic lateral sclerosis (is_implicated_in)	UNC13A ITPR2	5.89e-04	32	33	2	DOID:332 (is_implicated_in)
Disease	atrial fibrillation	ZFHX3 ZFHX4 ARHGAP21 ITPR2	7.54e-04	371	33	4	EFO_0000275
Disease	epilepsy (implicated_via_orthology)	UNC13B UNC13A ETNK2	7.99e-04	163	33	3	DOID:1826 (implicated_via_orthology)
Disease	age at onset, alcohol dependence	SI UTP20	1.02e-03	42	33	2	EFO_0004847, MONDO_0007079
Disease	Diabetes Mellitus, Sudden-Onset	C1QTNF6 ITPR3	1.11e-03	44	33	2	C4554117
Disease	Diabetes Mellitus, Ketosis-Prone	C1QTNF6 ITPR3	1.11e-03	44	33	2	C3837958
Disease	Diabetes, Autoimmune	C1QTNF6 ITPR3	1.11e-03	44	33	2	C0205734
Disease	Brittle diabetes	C1QTNF6 ITPR3	1.11e-03	44	33	2	C0342302
Disease	Diabetes Mellitus, Insulin-Dependent	C1QTNF6 ITPR3	1.17e-03	45	33	2	C0011854
Disease	alcohol use disorder (implicated_via_orthology)	UNC13B PBRM1 UNC13A	1.34e-03	195	33	3	DOID:1574 (implicated_via_orthology)
Disease	QT interval	ZFHX3 TRPM7 ARHGAP21 ITPR2	2.86e-03	534	33	4	EFO_0004682
Disease	Graves disease	C1QTNF6 ITPR3	3.72e-03	81	33	2	EFO_0004237

Protein segments in the cluster

Peptide	Gene	Start	Entry
ADYMNLHFKVKWLYN	UNC13A	1111	Q9UPW8
EYIKMGKWVYHNHIF	ARMT1	321	Q9H993
IMKTYGHTYEKHWWQ	ARFGEF1	1411	Q9Y6D6
EHIKSEHNMWHYLYF	ITPR2	2581	Q14571
EEHIKLEHNMWNYLY	ITPR3	2556	Q14573
HYFEQLHYNDMWLKV	PBRM1	1146	Q86U86
NIHYLNDGLWHMKTY	MCTS1	166	Q9ULC4
NIHYLNDGLWHMKTY	MCTS2	166	A0A3B3IRV3
WYHMYGENVHKLSIN	TMPRSS15	426	P98073
LWHKMHNYFTLVKNE	ETNK2	196	Q9NVF9
ELHLYSTWKKYQEAM	FAM153A	21	Q9UHL3
DWHTKHMNYHKKYPE	MED23	916	Q9ULK4
EINAHKYWNDFYKIH	METTL2B	71	Q6P1Q9
VEMWLHHYSLEMYQK	SMPD4	306	Q9NXE4
EINAHKYWNDFYKIH	METTL2A	71	Q96IZ6
NVHSWNYKETYVHIM	C1QTNF6	196	Q9BXI9
HTWNYKETYLHIMLN	C1QTNF8	171	P60827
HAHEMENKQFWKVYY	UTP20	746	O75691
LHYDVHNLYGWSQMK	SI	1451	P14410
ELYVNHKVYTRHMTW	POLR1C	161	O15160
LMYDILDWKRQHQHY	SPAG17	351	Q6Q759
LNWHMKKHTAEVQYN	ZNF653	571	Q96CK0
WHYKYQQTLEAHMKE	ZFHX4	651	Q86UP3
DSYLKYVGWTMHDKQ	STAG2	326	Q8N3U4
FQHLMQKRKHTQWTY	TRPV6	296	Q9H1D0
ADYMNLHFKVKWLHN	UNC13B	1031	O14795
IGQYYKWKKMDLQHQ	UBE2U	206	Q5VVX9
LKSHMWKHASDQNYN	ZNF507	801	Q8TCN5
HSWRKMYLKESHNYQ	ZNF112	181	Q9UJU3
KCEQHLGHNAMYWYK	TRBV4-3	41	A0A589
LGHDTMYWYKQDSKK	TRBV3-1	46	A0A576
HQHIDWKNYKTYKEY	ARHGAP21	381	Q5T5U3
HLMLYDYKQGHWNQL	TMEM45A	76	Q9NWC5
KCEQHLGHNAMYWYK	TRBV4-2	41	A0A539
WKYQRYHFIMAYHEK	TRPM7	1111	Q96QT4
CNWHYKYQQTLEAHM	ZFHX3	676	Q15911