Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction[heparan sulfate]-glucosamine N-sulfotransferase activity

NDST4 NDST2

1.14e-054282GO:0015016
GeneOntologyMolecularFunctionN-acetylglucosamine deacetylase activity

NDST4 NDST2

1.14e-054282GO:0050119
GeneOntologyMolecularFunctionubiquitin conjugating enzyme activity

UBE2D2 UBE2D3 UBE2D4

1.86e-0537283GO:0061631
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme activity

UBE2D2 UBE2D3 UBE2D4

2.93e-0543283GO:0061650
GeneOntologyMolecularFunctionubiquitin protein ligase binding

ERBB3 UBE2D2 UBE2D3 UBE2D4 KCNH2

9.49e-05337285GO:0031625
GeneOntologyMolecularFunctionubiquitin-like protein ligase binding

ERBB3 UBE2D2 UBE2D3 UBE2D4 KCNH2

1.26e-04358285GO:0044389
GeneOntologyMolecularFunctionheparan sulfate sulfotransferase activity

NDST4 NDST2

1.97e-0415282GO:0034483
GeneOntologyMolecularFunctiondiacylglycerol-dependent serine/threonine kinase activity

PRKD2 PRKCQ

2.25e-0416282GO:0004697
GeneOntologyMolecularFunctiondeacetylase activity

NDST4 NDST2

1.43e-0340282GO:0019213
GeneOntologyMolecularFunctionsulfotransferase activity

NDST4 NDST2

2.69e-0355282GO:0008146
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

PRKD2 ERBB3 PRKCQ PAK6 PIK3C2G

2.77e-03709285GO:0016773
GeneOntologyMolecularFunctionkinase activity

PRKD2 ERBB3 PRKCQ PAK6 PIK3C2G

3.82e-03764285GO:0016301
GeneOntologyMolecularFunctiontransferase activity, transferring sulphur-containing groups

NDST4 NDST2

4.81e-0374282GO:0016782
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

NDST4 NDST2

5.74e-0381282GO:0016811
GeneOntologyBiologicalProcessprotein K29-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4

6.35e-0713283GO:0035519
GeneOntologyBiologicalProcessprotein K27-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4

8.07e-0714283GO:0044314
GeneOntologyBiologicalProcessprotein K6-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4

1.50e-0617283GO:0085020
GeneOntologyBiologicalProcessprotein K11-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4

1.69e-0537283GO:0070979
GeneOntologyBiologicalProcessheparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

NDST4 NDST2

4.95e-058282GO:0015014
GeneOntologyBiologicalProcessheparin biosynthetic process

NDST4 NDST2

9.70e-0511282GO:0030210
GeneOntologyBiologicalProcessprotein K63-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4

1.47e-0476283GO:0070534
GeneOntologyBiologicalProcessheparin metabolic process

NDST4 NDST2

2.39e-0417282GO:0030202
GeneOntologyBiologicalProcessprotein K48-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4

3.32e-04100283GO:0070936
HumanPhenoPsychic epileptic aura

RELN PDE2A

5.18e-051062HP:0033346
HumanPhenoExperiential epileptic aura

RELN PDE2A

5.18e-051062HP:0012002
HumanPhenoFocal autonomic seizure

RELN PDE2A

6.33e-051162HP:0011154
HumanPhenoFocal sensory seizure

RELN PDE2A

2.64e-042262HP:0011157
HumanPhenoAbnormal autonomic nervous system physiology

ERBB3 RELN KCNH2

3.07e-0413063HP:0012332
HumanPhenoEpileptic aura

RELN PDE2A

3.43e-042562HP:0033348
DomainUBQ-conjugating_AS

UBE2D2 UBE2D3 UBE2D4

6.07e-0625273IPR023313
DomainHSNSD

NDST4 NDST2

1.21e-054272PF12062
DomainHeparan_SO4_deacetylase

NDST4 NDST2

1.21e-054272IPR021930
DomainUQ_con

UBE2D2 UBE2D3 UBE2D4

2.38e-0539273PF00179
DomainUBIQUITIN_CONJUGAT_1

UBE2D2 UBE2D3 UBE2D4

2.57e-0540273PS00183
DomainUBIQUITIN_CONJUGAT_2

UBE2D2 UBE2D3 UBE2D4

2.77e-0541273PS50127
DomainUBQ-conjugat_E2

UBE2D2 UBE2D3 UBE2D4

2.77e-0541273IPR000608
Domain-

UBE2D2 UBE2D3 UBE2D4

5.36e-05512733.10.110.10
DomainUBQ-conjugating_enzyme/RWD

UBE2D2 UBE2D3 UBE2D4

6.01e-0553273IPR016135
DomainKinase-like_dom

PRKD2 ERBB3 PRKCQ ACAD10 PAK6 PIK3C2G

1.02e-04542276IPR011009
DomainDAG/PE-bd

PRKD2 PRKCQ

4.16e-0421272IPR020454
DomainSulfotransferase_dom

NDST4 NDST2

1.23e-0336272IPR000863
DomainSulfotransfer_1

NDST4 NDST2

1.23e-0336272PF00685
DomainC1_1

PRKD2 PRKCQ

3.06e-0357272PF00130
DomainZF_DAG_PE_1

PRKD2 PRKCQ

3.84e-0364272PS00479
DomainZF_DAG_PE_2

PRKD2 PRKCQ

3.84e-0364272PS50081
DomainC1

PRKD2 PRKCQ

3.96e-0365272SM00109
DomainPROTEIN_KINASE_ATP

PRKD2 ERBB3 PRKCQ PAK6

4.04e-03459274PS00107
DomainPE/DAG-bd

PRKD2 PRKCQ

4.08e-0366272IPR002219
DomainProt_kinase_dom

PRKD2 ERBB3 PRKCQ PAK6

5.05e-03489274IPR000719
DomainPROTEIN_KINASE_DOM

PRKD2 ERBB3 PRKCQ PAK6

5.20e-03493274PS50011
DomainSer/Thr_kinase_AS

PRKD2 PRKCQ PAK6

1.44e-02357273IPR008271
DomainS_TKc

PRKD2 PRKCQ PAK6

1.46e-02359273SM00220
DomainPROTEIN_KINASE_ST

PRKD2 PRKCQ PAK6

1.50e-02362273PS00108
DomainProtein_kinase_ATP_BS

PRKD2 PRKCQ PAK6

1.69e-02379273IPR017441
DomainPkinase

PRKD2 PRKCQ PAK6

1.71e-02381273PF00069
DomainC2

PRKCQ PIK3C2G

1.78e-02142272PS50004
PathwayKEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS

NDST4 NDST2

1.15e-0411212M47921
PathwayWP_GLIOBLASTOMA_SIGNALING

ERBB3 PRKCQ PIK3C2G

2.42e-0483213M39637
PathwayREACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING

UBE2D2 UBE2D3

3.19e-0418212MM15680
PathwayREACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT

UBE2D2 UBE2D3

3.56e-0419212M27020
PathwayREACTOME_SIGNALING_BY_CSF3_G_CSF

UBE2D2 UBE2D3

4.80e-0422212MM15675
PathwayREACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1

UBE2D2 UBE2D3

5.25e-0423212M1003
PathwayREACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING

UBE2D2 UBE2D3

6.21e-0425212M41829
PathwayREACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1

UBE2D2 UBE2D3

6.21e-0425212MM15646
PathwayKEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE

NDST4 NDST2

6.72e-0426212M7330
PathwayREACTOME_HS_GAG_BIOSYNTHESIS

NDST4 NDST2

8.38e-0429212MM14802
PathwayREACTOME_SIGNALING_BY_CSF3_G_CSF

UBE2D2 UBE2D3

8.97e-0430212M41825
PathwayREACTOME_HS_GAG_BIOSYNTHESIS

NDST4 NDST2

9.58e-0431212M685
PathwayKEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS

UBE2D2 UBE2D3 UBE2D4

1.01e-03135213M15247
PathwayREACTOME_PINK1_PRKN_MEDIATED_MITOPHAGY

UBE2D2 UBE2D3

1.02e-0332212M27419
PathwayREACTOME_PINK1_PRKN_MEDIATED_MITOPHAGY

UBE2D2 UBE2D3

1.15e-0334212MM15167
PathwayREACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING

UBE2D2 UBE2D3

1.22e-0335212M985
PathwayREACTOME_MITOPHAGY

UBE2D2 UBE2D3

1.52e-0339212M27418
PathwayPID_ERBB1_INTERNALIZATION_PATHWAY

UBE2D2 UBE2D3

1.67e-0341212M214
PathwayREACTOME_MITOPHAGY

UBE2D2 UBE2D3

1.67e-0341212MM15166
PathwayWP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS

NDST4 NDST2

1.67e-0341212M48095
PathwayREACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS

UBE2D2 UBE2D3

2.01e-0345212MM15508
PathwayREACTOME_REGULATION_OF_TNFR1_SIGNALING

UBE2D2 UBE2D3

2.19e-0347212MM15179
PathwayREACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

NDST4 NDST2

2.89e-0354212MM14633
PathwayREACTOME_TNF_SIGNALING

UBE2D2 UBE2D3

3.10e-0356212MM15453
PathwayWP_PROTEASOME_DEGRADATION

UBE2D2 UBE2D3

3.10e-0356212MM15901
PathwayREACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

NDST4 NDST2

3.21e-0357212M692
PathwayREACTOME_TNF_SIGNALING

UBE2D2 UBE2D3

3.21e-0357212M27713
PathwayREACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS

UBE2D2 UBE2D3

3.44e-0359212M27763
PathwayWP_PROTEASOME_DEGRADATION

UBE2D2 UBE2D3

3.79e-0362212M39639
PathwayREACTOME_PEROXISOMAL_PROTEIN_IMPORT

UBE2D2 UBE2D3

3.91e-0363212M27915
PathwayREACTOME_PROTEIN_UBIQUITINATION

UBE2D2 UBE2D3

4.15e-0365212MM15490
PathwayREACTOME_PEROXISOMAL_PROTEIN_IMPORT

UBE2D2 UBE2D3

4.15e-0365212MM15628
Pubmed

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

UBE2D2 UBE2D3 UBE2D4

1.63e-08728321685362
Pubmed

Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.

UBE2D2 UBE2D3 UBE2D4

1.63e-08728330884854
Pubmed

Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.

UBE2D2 UBE2D3 UBE2D4

2.61e-08828328681414
Pubmed

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.

UBE2D2 UBE2D3 UBE2D4

2.61e-08828323560854
Pubmed

Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.

UBE2D2 UBE2D3 UBE2D4

2.61e-08828329323787
Pubmed

Mechanism and chain specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon Holmes syndrome.

UBE2D2 UBE2D3 UBE2D4

5.59e-081028331087003
Pubmed

Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.

UBE2D2 UBE2D3 UBE2D4

5.59e-081028328757353
Pubmed

The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.

UBE2D2 UBE2D3 UBE2D4

1.02e-071228324211586
Pubmed

Ubiquitination of STING at lysine 224 controls IRF3 activation.

UBE2D2 UBE2D3 UBE2D4

1.33e-071328328763789
Pubmed

Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.

UBE2D2 UBE2D3 UBE2D4

1.69e-071428336481767
Pubmed

Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.

UBE2D2 UBE2D3 UBE2D4

3.15e-071728333650289
Pubmed

Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.

UBE2D2 UBE2D3 UBE2D4

3.15e-071728336563856
Pubmed

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.

UBE2D2 UBE2D3 UBE2D4

4.49e-071928327425610
Pubmed

Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity.

UBE2D2 UBE2D4

6.25e-07228226912277
Pubmed

The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway.

UBE2D2 UBE2D3 UBE2D4

8.19e-072328330017913
Pubmed

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.

UBE2D2 UBE2D3 UBE2D4

9.35e-072428324647965
Pubmed

Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.

UBE2D2 UBE2D3 UBE2D4

9.35e-072428334195792
Pubmed

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

UBE2D2 UBE2D3 UBE2D4

1.20e-062628320061386
Pubmed

Functional interactions between ubiquitin E2 enzymes and TRIM proteins.

UBE2D2 UBE2D3 UBE2D4

1.35e-062728321143188
Pubmed

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.

UBE2D2 UBE2D3 UBE2D4

1.35e-062728330097011
Pubmed

Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase.

UBE2D2 UBE2D3

1.87e-06328230095198
Pubmed

Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.

UBE2D2 UBE2D3

1.87e-06328211912157
Pubmed

Identification of a family of closely related human ubiquitin conjugating enzymes.

UBE2D2 UBE2D3

1.87e-0632828530467
Pubmed

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

PRKD2 ERBB3 PRKCQ

3.56e-063728319430480
Pubmed

Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.

NDST4 NDST2

3.75e-06428222049073
Pubmed

Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1.

UBE2D2 UBE2D3

3.75e-0642829535861
Pubmed

Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.

UBE2D2 UBE2D3

3.75e-06428220696396
Pubmed

Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.

NDST4 NDST2

3.75e-06428212070138
Pubmed

Physical and functional interactions between ZIP kinase and UbcH5.

UBE2D2 UBE2D3

3.75e-06428218515077
Pubmed

The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity.

UBE2D2 UBE2D3

3.75e-06428231241013
Pubmed

Protein kinase Cδ mediates the activation of protein kinase D2 in platelets.

PRKD2 PRKCQ

3.75e-06428221736870
Pubmed

Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates.

UBE2D2 UBE2D3 UBE2D4

3.87e-063828335331737
Pubmed

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.

UBE2D2 UBE2D3

6.24e-06528223509263
Pubmed

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

UBE2D2 UBE2D3

6.24e-06528210329681
Pubmed

ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains.

UBE2D2 UBE2D3

6.24e-06528216413270
Pubmed

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.

UBE2D2 UBE2D3

6.24e-06528225327252
Pubmed

The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.

UBE2D2 UBE2D3

6.24e-06528214562029
Pubmed

E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).

UBE2D2 UBE2D3

6.24e-06528215684077
Pubmed

Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.

UBE2D2 UBE2D3

6.24e-06528226502057
Pubmed

Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism.

UBE2D2 UBE2D3

6.24e-06528223408431
Pubmed

The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2: crystallization and X-ray diffraction.

UBE2D2 UBE2D3

6.24e-06528231929179
Pubmed

Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.

NDST4 NDST2

6.24e-06528211087757
Pubmed

A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.

UBE2D2 UBE2D3

6.24e-06528218313049
Pubmed

Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.

UBE2D2 UBE2D3

6.24e-06528219741096
Pubmed

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

UBE2D2 UBE2D3

6.24e-0652828090726
Pubmed

Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.

UBE2D2 UBE2D3

9.36e-0662829990509
Pubmed

Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.

UBE2D2 UBE2D3

9.36e-06628227678051
Pubmed

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

UBE2D2 UBE2D3

9.36e-06628215280377
Pubmed

Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114.

UBE2D2 UBE2D3

9.36e-06628228625874
Pubmed

h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes.

UBE2D2 UBE2D3

9.36e-06628216549277
Pubmed

The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.

UBE2D2 UBE2D3

9.36e-06628225701873
Pubmed

Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons.

UBE2D2 UBE2D3

9.36e-06628222976837
Pubmed

NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.

UBE2D2 UBE2D3

9.36e-06628233962630
Pubmed

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.

UBE2D2 UBE2D3

9.36e-06628222124327
Pubmed

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.

UBE2D2 UBE2D3

9.36e-06628230404641
Pubmed

Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.

UBE2D2 UBE2D3

1.31e-05728211714696
Pubmed

RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand.

UBE2D2 UBE2D3

1.31e-05728220553626
Pubmed

Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.

UBE2D2 UBE2D3

1.31e-05728220051513
Pubmed

A ubiquitin ligase complex assembles linear polyubiquitin chains.

UBE2D2 UBE2D3

1.31e-05728217006537
Pubmed

The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.

UBE2D2 UBE2D3

1.31e-05728225278022
Pubmed

Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.

UBE2D2 UBE2D3

1.31e-05728228322253
Pubmed

Measuring rates of ubiquitin chain formation as a functional readout of ligase activity.

UBE2D2 UBE2D3

1.31e-05728222350887
Pubmed

In Vitro Analysis of E3 Ubiquitin Ligase Function.

UBE2D2 UBE2D3

1.31e-05728234057440
Pubmed

Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.

UBE2D2 UBE2D3

1.31e-05728220347421
Pubmed

Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.

UBE2D2 UBE2D3

1.31e-05728222613722
Pubmed

Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein stability and function in ER Stress.

UBE2D2 UBE2D3

1.31e-05728221068390
Pubmed

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.

UBE2D2 UBE2D3

1.31e-05728224831002
Pubmed

UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I.

UBE2D2 UBE2D3

1.31e-05728217719635
Pubmed

The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response.

UBE2D2 UBE2D3

1.31e-05728233282879
Pubmed

MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.

UBE2D2 UBE2D3

1.74e-05828225207814
Pubmed

E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.

UBE2D2 UBE2D3

1.74e-05828224446487
Pubmed

Involvement of Rabring7 in EGF receptor degradation as an E3 ligase.

UBE2D2 UBE2D3

1.74e-05828217462600
Pubmed

A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control.

UBE2D2 UBE2D3

1.74e-05828216682404
Pubmed

Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.

UBE2D2 UBE2D3

1.74e-05828214661060
Pubmed

The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.

UBE2D2 UBE2D3

1.74e-05828212670957
Pubmed

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

UBE2D2 UBE2D3

1.74e-05828215247280
Pubmed

The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly.

UBE2D2 UBE2D3

1.74e-05828228972136
Pubmed

FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.

NDST4 NDST2

1.74e-05828224067353
Pubmed

Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.

UBE2D2 UBE2D3

1.74e-05828218838541
Pubmed

Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO.

UBE2D2 UBE2D3

2.24e-05928212525502
Pubmed

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.

UBE2D2 UBE2D3

2.24e-05928217460044
Pubmed

Comparison of Cross-Regulation by Different OTUB1:E2 Complexes.

UBE2D2 UBE2D3

2.24e-05928232049508
Pubmed

TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.

UBE2D2 UBE2D3

2.24e-05928217544371
Pubmed

Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.

UBE2D2 UBE2D3

2.24e-05928226711259
Pubmed

Bag1 directly routes immature BCR-ABL for proteasomal degradation.

UBE2D2 UBE2D3

2.80e-051028220675402
Pubmed

Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib.

UBE2D2 UBE2D3

2.80e-051028233607208
Pubmed

E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.

UBE2D2 UBE2D3

2.80e-051028221518764
Pubmed

Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.

UBE2D2 UBE2D3

2.80e-051028237345264
Pubmed

A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing.

UBE2D2 UBE2D3

3.42e-051128236027913
Pubmed

Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.

UBE2D2 UBE2D3

3.42e-051128224438103
Pubmed

Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.

UBE2D2 UBE2D3

3.42e-051128219712108
Pubmed

Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.

NDST4 NDST2

3.42e-051128215944372
Pubmed

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.

UBE2D2 UBE2D3

3.42e-051128222334663
Pubmed

Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.

NDST4 ERBB3 NDST2

3.82e-058128339217171
Pubmed

E1-E2 interactions in ubiquitin and Nedd8 ligation pathways.

UBE2D2 UBE2D3

4.10e-051228222069333
Pubmed

Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.

NDST4 NDST2

4.10e-051228212460940
Pubmed

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.

UBE2D2 UBE2D3

4.10e-051228224905733
Pubmed

Cbl interacts with multiple E2s in vitro and in cells.

UBE2D2 UBE2D3

4.85e-051328231120930
Pubmed

TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.

UBE2D2 UBE2D3

4.85e-051328236576150
Pubmed

Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation.

UBE2D2 UBE2D3

4.85e-051328223530056
InteractionDTX1 interactions

PRKCQ UBE2D2 UBE2D3 UBE2D4

1.51e-0735284int:DTX1
InteractionARK2C interactions

UBE2D2 UBE2D3 UBE2D4

5.24e-0712283int:ARK2C
InteractionTRIM43 interactions

ACAD10 UBE2D2 UBE2D3 UBE2D4

8.33e-0753284int:TRIM43
InteractionRNF26 interactions

PDE2A UBE2D2 UBE2D3 UBE2D4

1.38e-0660284int:RNF26
InteractionRNF150 interactions

UBE2D2 UBE2D3 UBE2D4

2.70e-0620283int:RNF150
InteractionUBOX5 interactions

UBE2D2 UBE2D3 UBE2D4

4.18e-0623283int:UBOX5
InteractionRFFL interactions

PRKD2 UBE2D2 UBE2D3 KCNH2

5.08e-0683284int:RFFL
InteractionRNF103 interactions

UBE2D2 UBE2D3 UBE2D4

8.57e-0629283int:RNF103
InteractionCADPS2 interactions

UBE2D2 UBE2D3 UBE2D4

9.51e-0630283int:CADPS2
InteractionTRIM62 interactions

UBE2D2 UBE2D3 UBE2D4

1.16e-0532283int:TRIM62
InteractionBIRC8 interactions

UBE2D2 UBE2D3 UBE2D4

1.16e-0532283int:BIRC8
InteractionTRIM45 interactions

UBE2D2 UBE2D3 UBE2D4

1.27e-0533283int:TRIM45
InteractionTRIM17 interactions

UBE2D2 UBE2D3 UBE2D4

1.40e-0534283int:TRIM17
InteractionZNRF1 interactions

UBE2D2 UBE2D3 UBE2D4

1.66e-0536283int:ZNRF1
InteractionUVSSA interactions

UBE2D2 UBE2D3 UBE2D4

1.81e-0537283int:UVSSA
InteractionUBTD1 interactions

UBE2D2 UBE2D3 UBE2D4

2.29e-0540283int:UBTD1
InteractionRNF25 interactions

UBE2D2 UBE2D3 UBE2D4

2.86e-0543283int:RNF25
InteractionMARCHF3 interactions

UBE2D2 UBE2D3 UBE2D4

2.86e-0543283int:MARCHF3
InteractionTRIM38 interactions

UBE2D2 UBE2D3 UBE2D4

3.74e-0547283int:TRIM38
InteractionZNRF2 interactions

UBE2D2 UBE2D3 UBE2D4

3.74e-0547283int:ZNRF2
InteractionTRIM10 interactions

UBE2D2 UBE2D3 UBE2D4

3.98e-0548283int:TRIM10
InteractionBFAR interactions

UBE2D2 UBE2D3 UBE2D4

3.98e-0548283int:BFAR
InteractionTRIM50 interactions

UBE2D2 UBE2D3 UBE2D4

4.24e-0549283int:TRIM50
InteractionRNF14 interactions

UBE2D2 UBE2D3 UBE2D4

4.24e-0549283int:RNF14
InteractionRMND5B interactions

UBE2D2 UBE2D3 UBE2D4

4.24e-0549283int:RMND5B
InteractionRNF216 interactions

UBE2D2 UBE2D3 UBE2D4

5.07e-0552283int:RNF216
InteractionRNF125 interactions

UBE2D2 UBE2D3 UBE2D4

5.37e-0553283int:RNF125
InteractionTRIM2 interactions

UBE2D2 UBE2D3 UBE2D4

5.37e-0553283int:TRIM2
InteractionRNF167 interactions

UBE2D2 UBE2D3 UBE2D4

5.68e-0554283int:RNF167
InteractionMYLIP interactions

UBE2D2 UBE2D3 UBE2D4

6.34e-0556283int:MYLIP
InteractionNDST3 interactions

NDST4 NDST2

6.66e-059282int:NDST3
InteractionRNF13 interactions

UBE2D2 UBE2D3 UBE2D4

7.79e-0560283int:RNF13
InteractionCHFR interactions

UBE2D2 UBE2D3 UBE2D4

7.79e-0560283int:CHFR
InteractionPELI1 interactions

PRKCQ UBE2D2 UBE2D3

9.90e-0565283int:PELI1
InteractionCNOT4 interactions

UBE2D2 UBE2D3 UBE2D4

9.90e-0565283int:CNOT4
InteractionDTX3L interactions

UBE2D2 UBE2D3 UBE2D4

1.13e-0468283int:DTX3L
InteractionITCH interactions

ERBB3 PDE2A UBE2D2 UBE2D3 UBE2D4

1.18e-04356285int:ITCH
InteractionSLC31A1 interactions

DPH1 ERBB3 PDE2A ACAD10

1.37e-04192284int:SLC31A1
InteractionUBA1 interactions

PRKD2 DPP3 UBE2D2 UBE2D3 UBE2D4

1.60e-04380285int:UBA1
InteractionUHRF2 interactions

ZNF384 UBE2D2 UBE2D3 UBE2D4

1.60e-04200284int:UHRF2
InteractionF12 interactions

ACAD10 UBE2D2 UBE2D3

1.64e-0477283int:F12
InteractionTRIM3 interactions

UBE2D2 UBE2D3 UBE2D4

1.84e-0480283int:TRIM3
InteractionRFWD3 interactions

UBE2D2 UBE2D3 UBE2D4

1.84e-0480283int:RFWD3
InteractionRNF122 interactions

UBE2D2 UBE2D3

2.21e-0416282int:RNF122
InteractionSQSTM1 interactions

ZNF384 RELN FASTKD2 ACAD10 USP54 UBE2D2 UBE2D3 GPBP1

2.26e-041257288int:SQSTM1
InteractionRNF10 interactions

UBE2D2 UBE2D3 UBE2D4

2.35e-0487283int:RNF10
InteractionLRSAM1 interactions

UBE2D2 UBE2D3 UBE2D4

2.44e-0488283int:LRSAM1
InteractionMGRN1 interactions

UBE2D2 UBE2D3 UBE2D4

2.60e-0490283int:MGRN1
InteractionRNF114 interactions

UBE2D2 UBE2D3 UBE2D4

2.69e-0491283int:RNF114
InteractionRNF166 interactions

UBE2D2 UBE2D3 UBE2D4

2.69e-0491283int:RNF166
InteractionTRIM5 interactions

UBE2D2 UBE2D3 UBE2D4

2.69e-0491283int:TRIM5
InteractionTOPORS interactions

UBE2D2 UBE2D3 UBE2D4

3.15e-0496283int:TOPORS
InteractionRNF111 interactions

UBE2D2 UBE2D3 UBE2D4

3.24e-0497283int:RNF111
InteractionTRIM8 interactions

UBE2D2 UBE2D3 UBE2D4

3.55e-04100283int:TRIM8
InteractionMUL1 interactions

UBE2D2 UBE2D3 UBE2D4

3.65e-04101283int:MUL1
InteractionRNF38 interactions

UBE2D2 UBE2D3 UBE2D4

3.76e-04102283int:RNF38
InteractionTRIM35 interactions

UBE2D2 UBE2D3 UBE2D4

3.87e-04103283int:TRIM35
InteractionTRIM39 interactions

UBE2D2 UBE2D3 UBE2D4

4.45e-04108283int:TRIM39
InteractionDTX3 interactions

UBE2D2 UBE2D3 UBE2D4

4.45e-04108283int:DTX3
InteractionUBE4A interactions

UBE2D2 UBE2D3 UBE2D4

4.57e-04109283int:UBE4A
InteractionZNRF4 interactions

UBE2D2 UBE2D3 UBE2D4

4.69e-04110283int:ZNRF4
InteractionMID2 interactions

USP54 UBE2D2 UBE2D3 UBE2D4

4.80e-04267284int:MID2
InteractionUFM1 interactions

UBE2D2 UBE2D3 UBE2D4

5.62e-04117283int:UFM1
InteractionMID1 interactions

UBE2D2 UBE2D3 UBE2D4

5.90e-04119283int:MID1
InteractionPOLM interactions

UBE2D2 UBE2D3

5.93e-0426282int:POLM
InteractionAREL1 interactions

UBE2D2 UBE2D3

6.39e-0427282int:AREL1
InteractionRNF5 interactions

UBE2D2 UBE2D3 UBE2D4

6.97e-04126283int:RNF5
InteractionPHF7 interactions

UBE2D2 UBE2D4

7.90e-0430282int:PHF7
InteractionRNF115 interactions

UBE2D2 UBE2D3 UBE2D4

8.34e-04134283int:RNF115
InteractionWSB1 interactions

UBE2D2 UBE2D3

8.44e-0431282int:WSB1
InteractionRNF126 interactions

UBE2D2 UBE2D3 UBE2D4

9.08e-04138283int:RNF126
InteractionNEDD4L interactions

ERBB3 UBE2D2 UBE2D3 KCNH2

9.45e-04320284int:NEDD4L
InteractionNDST1 interactions

NDST4 NDST2

1.02e-0334282int:NDST1
InteractionDTX2 interactions

USP54 UBE2D2 UBE2D3 UBE2D4

1.06e-03330284int:DTX2
InteractionUBE2K interactions

ZNF384 UBE2D2 UBE2D3

1.13e-03149283int:UBE2K
InteractionRNF7 interactions

UBE2D2 UBE2D3 UBE2D4

1.16e-03150283int:RNF7
InteractionHECW1 interactions

UBE2D2 UBE2D3

1.20e-0337282int:HECW1
InteractionPJA2 interactions

UBE2D2 UBE2D3 UBE2D4

1.25e-03154283int:PJA2
InteractionVLDLR interactions

RELN NDST2

1.34e-0339282int:VLDLR
InteractionRNF185 interactions

UBE2D2 UBE2D3 UBE2D4

1.34e-03158283int:RNF185
InteractionRNF181 interactions

UBE2D2 UBE2D3 UBE2D4

1.39e-03160283int:RNF181
InteractionMAP3K1 interactions

UBE2D2 UBE2D3 UBE2D4

1.42e-03161283int:MAP3K1
InteractionNSMCE1 interactions

ERBB3 UBE2D2

1.55e-0342282int:NSMCE1
InteractionRNF220 interactions

UBE2D2 UBE2D3

1.55e-0342282int:RNF220
InteractionRNF11 interactions

UBE2D2 UBE2D3 UBE2D4

1.63e-03169283int:RNF11
InteractionLNX1 interactions

SLC6A15 USP54 UBE2D2 PAK6 UBE2D4

1.63e-03634285int:LNX1
InteractionRBCK1 interactions

UBE2D2 UBE2D3 UBE2D4

1.83e-03176283int:RBCK1
InteractionPRSS50 interactions

ACAD10 USP54

1.86e-0346282int:PRSS50
InteractionFBXO4 interactions

UBE2D2 UBE2D3

1.86e-0346282int:FBXO4
InteractionTMA7 interactions

PRKD2 ERBB3

1.86e-0346282int:TMA7
InteractionMDM2 interactions

ERBB3 UBE2D2 UBE2D3 PAK6 UBE2D4

1.92e-03658285int:MDM2
InteractionDUSP14 interactions

ERBB3 UBE2D2 GPBP1

1.98e-03181283int:DUSP14
InteractionDZIP3 interactions

UBE2D2 UBE2D3 UBE2D4

2.04e-03183283int:DZIP3
Cytoband12p12

ZNF384 PIK3C2G

2.79e-051328212p12
GeneFamilyUbiquitin conjugating enzymes E2

UBE2D2 UBE2D3 UBE2D4

1.62e-0541223102
GeneFamilySulfotransferases, membrane bound

NDST4 NDST2

9.17e-0437222763
GeneFamilyImmunoglobulin like domain containing

FCRL5 NCR1

2.28e-02193222594
CoexpressionKRAS.300_UP.V1_UP

SLC6A15 RELN PDE2A KCNH2

1.57e-05143284M2875
CoexpressionGSE17186_MEMORY_VS_CD21HIGH_TRANSITIONAL_BCELL_UP

ERBB3 PDE2A USP54 UBE2D2

5.61e-05198284M7200
CoexpressionGSE44649_WT_VS_MIR155_KO_ACTIVATED_CD8_TCELL_UP

DPP3 GPBP1 XPO6 NDST2

5.72e-05199284M9782
CoexpressionGSE557_CIITA_KO_VS_I_AB_KO_DC_DN

NDST4 RELN PDE2A DPP3

5.83e-05200284M6014
CoexpressionBILD_MYC_ONCOGENIC_SIGNATURE

DPH1 SLC6A15 ERBB3 UBE2D4

6.92e-05209284M2069
CoexpressionWONG_ADULT_TISSUE_STEM_MODULE

SLC6A15 RELN PDE2A PRKCQ NCR1 PIK3C2G

9.53e-05721286M1999
CoexpressionDARWICHE_PAPILLOMA_PROGRESSION_RISK

RELN UBE2D2 UBE2D3

1.29e-0492283MM503
CoexpressionKIM_MYCN_AMPLIFICATION_TARGETS_UP

SLC6A15 ERBB3 PDE2A

1.33e-0493283M18532
CoexpressionKRAS.600_UP.V1_UP

SLC6A15 RELN PDE2A KCNH2

2.10e-04279284M2882
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN PRKCQ PIK3C2G

8.93e-051392839e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCellfacs-Lung-3m-Hematologic-Lymphocytic_NK_ILC|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE2A PRKCQ NCR1

1.12e-041502831f83e3be3f94aefe991a3ccd292c2d11ddef858e
ToppCellfacs-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE2A PRKCQ NCR1

1.12e-04150283cd666db614bc1b43d71e8eb7bf38cae4d580be80
ToppCellfacs-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE2A PRKCQ NCR1

1.12e-04150283f6ed3e7b36014d1e429b255b0027d89865e1ac07
ToppCellfacs-Liver-Non-hepatocytes-3m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKCQ PAK6 NCR1

1.21e-0415428375eac6970259a6916fcfa6d3400509cfa2d98d9d
ToppCelldroplet-Lung-nan-3m-Lymphocytic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.28e-04157283b337937a88f62030114a28d70a63168417672767
ToppCellSevere-Lymphoid-NK-Proliferating_T|Severe / Condition, Lineage, Cell class and cell subclass

FASTKD2 USP54 NCR1

1.35e-04160283cb2276d9bd78508644420e9580d3c17b914224cb
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PDE2A USP54 KCNH2

1.35e-0416028319105debef96ea0c267d6a1d332303ec668ae47e
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF362 FCRL5 USP54

1.38e-04161283249c2b97cc25de5053f5048ee354615df49b2081
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-CD45____NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB3 PRKCQ NCR1

1.41e-0416228304a96442e0fcdb6a65b9e45044021677f9f53d38
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB3 PRKCQ NCR1

1.41e-041622837adb3e279526e1f21033c10af0a0058258f21842
ToppCelldroplet-Lung-nan-3m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.41e-041622834b490989005bb03d4e7bbea01580f8548eff150f
ToppCelldroplet-Lung-nan-3m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.41e-04162283e4a09bf1a51710f6c57e6e01edf8b4619459d96d
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.43e-04163283a0315855c354e830e109d41bd6e3396488aa8de9
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.46e-04164283a59078c8f88e416e940c9b15151ce7de1bbe987e
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ERBB3 RELN PRKCQ

1.46e-041642833caf4cdaa0164907893fea61e251fd8b5fa926e4
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.48e-0416528393ed399b8c6278e5f1528c07758fb502d80a1a8b
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.48e-0416528380f82aaab48791cb06fcb2d8ed7821f162742385
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NDST4 ERBB3 USP54

1.48e-04165283f6887c64af0f26e33316bc5587487e24d76ece2a
ToppCelldroplet-Spleen-SPLEEN-1m-Lymphocytic-NK_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.48e-041652838741df8066a44c841752a99ad306d26ea68f5344
ToppCelldroplet-Lung-nan-21m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.51e-04166283325ece9d7dad2b92eeb4defa109853660ac133ca
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.51e-041662833213466380becf0ee3d4d9a0776ccbb1ee4eccea
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.51e-04166283be45610f2fe606c328f5688189be40df5e678557
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE2A PRKCQ NCR1

1.54e-04167283cde82e3dacf347226a78873b166608b7851b34d4
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE2A PRKCQ NCR1

1.54e-041672836f54a699d9266c5f09ed890a11b403a6c8476fc1
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE2A PRKCQ NCR1

1.54e-04167283895844a45721988788d01120eb880603ba3ca139
ToppCellfacs-Skin-Anagen-24m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A15 CCDC73 PIK3C2G

1.54e-0416728302c89069dcd0e87f7502e32b14e7cbd3cab81a09
ToppCellfacs-Spleen-nan-3m-Lymphocytic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ NCR1

1.56e-0416828374dc46738f1d0a448df6c9b8288b515d92697792
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)-|368C / Donor, Lineage, Cell class and subclass (all cells)

RELN PDE2A PIK3C2G

1.56e-04168283dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAK6 CCDC73 PIK3C2G

1.56e-0416828308f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)|368C / Donor, Lineage, Cell class and subclass (all cells)

RELN PDE2A PIK3C2G

1.56e-04168283a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF384 ACAD10 USP54

1.62e-041702830f215911b5880eeffeb43230f7eeaf55b612eaf2
ToppCelldroplet-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE2A PRKCQ NCR1

1.65e-04171283834b39b48bf3135dc41e787f5e20ebb234b5d97a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A15 RELN PDE2A

1.68e-04172283c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCelldroplet-Lung-3m-Hematologic-Lymphocytic_NK_ILC|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE2A PRKCQ NCR1

1.68e-04172283a749f4ab4048d806a83f1f71a197584b8db833ad
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERBB3 RELN APOBEC4

1.71e-04173283789ab8b2709f4b8728e3733bc72744e9d92ea5ea
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN PDE2A PRKCQ

1.76e-041752839d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN FASTKD2 PRKCQ

1.76e-04175283f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCellP15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN PDE2A PRKCQ

1.76e-0417528384d252f3e432231687613299bbea14978bb4b06b
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN PDE2A PRKCQ

1.76e-04175283f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCellP15-Endothelial-lymphatic_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN PDE2A PRKCQ

1.76e-04175283a00c6fa9b33640710dd05a3799031147196f0986
ToppCellP28-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN PDE2A PRKCQ

1.82e-04177283e96a7e4544710aaab8bd2800ecff9667880a8bf4
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-mature_NK_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A PRKCQ PAK6

1.82e-0417728352402ff6299210c46fd9dee3cef203c0eda7a98a
ToppCellP28-Endothelial-lymphatic_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN PDE2A PRKCQ

1.82e-041772836e330aa3c87fd640526b746a9deb3b2250d2518c
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN CCDC73 KCNH2

1.82e-0417728359cf56c385c324f0844f20003d2b5049a2791e45
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PDE2A PIK3C2G

1.82e-04177283dfaed388926ce050730492a532824af68bf4feff
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN PAK6 PIK3C2G

1.82e-041772839b02fd91c110b405eba6cb74ceb90b1286535973
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A15 RELN PIK3C2G

1.89e-0417928369a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A15 RELN PIK3C2G

1.89e-04179283479116ac65488c60104a053530830763ec1f95b2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A15 RELN PIK3C2G

1.89e-041792831dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCelldroplet-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC6A15 PAK6 PIK3C2G

1.89e-04179283ca70a5518c5a5392e088c103e0cb44aa084f5332
ToppCelldroplet-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC6A15 PAK6 PIK3C2G

1.89e-04179283c451b074b04eb5d6c575c6abaedda579c6744bbf
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|367C / Donor, Lineage, Cell class and subclass (all cells)

RELN PDE2A PIK3C2G

1.95e-04181283b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|367C / Donor, Lineage, Cell class and subclass (all cells)

RELN PDE2A PIK3C2G

1.95e-04181283dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCellcellseq2-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRKD2 PRKCQ NCR1

1.98e-041822838ccffcbae28c374fd4161fb0d4cf2c49fae557f6
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERBB3 RELN NDST2

2.01e-04183283547b1fb9f9940cfc8d6e351d96acc0da44def57e
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PDE2A PIK3C2G

2.01e-04183283a90ffd9c50caa65f537a2e441e37655e1b622327
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PDE2A PIK3C2G

2.01e-0418328313ad20ec140ef5b96fdace3369b5befc0f40bb76
ToppCellControl-Epithelial_alveolar-AT_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRKCQ ACAD10 USP54

2.04e-0418428351e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCelldroplet-Marrow-nan-21m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A15 PRKCQ NCR1

2.04e-041842837e129862f8d2353387999e633725325c4d8cb42e
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN PDE2A PRKCQ

2.08e-0418528359acaf025353405948dc34ccccf37ec5c08ea903
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN PRKCQ ACAD10

2.08e-04185283bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ERBB3 PRKCQ PIK3C2G

2.11e-04186283bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ERBB3 PRKCQ PIK3C2G

2.14e-04187283db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCellFetal_29-31_weeks-Immune-natural_killer_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PRKCQ NCR1 XPO6

2.18e-041882836686dbba990066568aa7573e70a7db8b4758f457
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC6A15 RELN NDST2

2.18e-04188283c2febf9fd4632af1f922067c3a30e5c50f75f480
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PDE2A PIK3C2G

2.25e-04190283b2bd2cb384bb8a5662064ed1aee68e905e1f780d
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PDE2A PIK3C2G

2.25e-0419028332400c62cb9de4c2b24af4206c21a0215ab12212
ToppCellControl-Lymphoid-ILC_A|Control / Disease state, Lineage and Cell class

PRKCQ NCR1 XPO6

2.28e-041912831ca73582dc3d28322b5ee841010067589d848acc
ToppCellnucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRKCQ NCR1 XPO6

2.32e-04192283a06d5d3c2537f8d2b1dc6b6f3e88a80b5c2a1850
ToppCellhuman_hepatoblastoma-NK.T_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

PRKCQ FCRL5 NCR1

2.39e-04194283997b02a22d7c89a8fd5615bb79a2a8a34fc3fee6
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PDE2A PIK3C2G

2.42e-0419528336d4a11bc77a4cc97a22525c78ef8359f4a3ca66
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ERBB3 PAK6 PIK3C2G

2.42e-0419528398dd3b7d5ef587825dac052dea4d4ff883f6d4d6
ToppCellnucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRKCQ NCR1 XPO6

2.42e-04195283ffb40486f8097b2c08e8f3b3685d0b8cb8d1bc66
ToppCellnucseq-Immune-Lymphocytic_T/NK|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRKCQ NCR1 XPO6

2.42e-04195283b8124e8a23e6d37b40023608674e67285c6ffe84
ToppCelldistal-3-Endothelial-Lymphatic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RELN PDE2A PIK3C2G

2.50e-041972839ea0e2ed9c3f97591a06e70570640996580417d5
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC6A15 ERBB3 USP54

2.50e-0419728354fb207638e211f8efdb13003ae62a6b1f003b09
ToppCelldistal-Endothelial-Lymphatic-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RELN PDE2A PIK3C2G

2.50e-041972838f2e19409ebe9a490d5a245fa82c765ed6d77c3e
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

RELN PDE2A PIK3C2G

2.57e-041992831587d24b19f5bb64a3b6cc1df87c7c472cf41672
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

RELN PDE2A PIK3C2G

2.57e-04199283a9c2041e54899cb8ccc026758647f3ae3ca457dd
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

RELN PDE2A PIK3C2G

2.61e-0420028376e90231aa94afc12e618da8ae314c51644acab4
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-KLHDC8A|Neuronal / cells hierarchy compared to all cells using T-Statistic

NDST4 ERBB3 RELN

2.61e-0420028305bcde6ce8f1354ef65e4eb9cbd963a92108081c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Macroglial-Glia_progenitor_cell|GW16 / Sample Type, Dataset, Time_group, and Cell type.

ERBB3 PRKCQ PIK3C2G

2.61e-042002836c1b7b0f3cd35d8cfee181ea83c73127dbc41ac5
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

RELN PDE2A PIK3C2G

2.61e-04200283e3e80cb16e0d2e24efc16b62316a6da91bf81ea5
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-KLHDC8A-|Neuronal / cells hierarchy compared to all cells using T-Statistic

NDST4 ERBB3 RELN

2.61e-042002831a04331862079092bc04b1010aa9228c0fa3d8c5
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-KLHDC8A--L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

NDST4 ERBB3 RELN

2.61e-04200283fb56d430957e73fba17db7bc0127ecf3577e0867
ComputationalGenes in the cancer module 4.

UBE2D2 UBE2D3

4.86e-0421172MODULE_4
ComputationalGenes in the cancer module 233.

UBE2D2 UBE2D3

5.34e-0422172MODULE_233
ComputationalGenes in the cancer module 82.

UBE2D2 UBE2D3

6.37e-0424172MODULE_82
ComputationalProteasome.

UBE2D2 UBE2D3

1.52e-0337172MODULE_91
Drugvanadyl

PRKD2 ERBB3 PDE2A NCR1 PIK3C2G

2.73e-05307275CID000061671
DrugGF109203X

PRKD2 ERBB3 PRKCQ PIK3C2G KCNH2

4.51e-05341275CID000002396
DrugMeclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; HL60; HT_HG-U133A

FASTKD2 ACAD10 UBE2D4 NDST2

7.54e-051932741341_UP
DrugFluorocurarine chloride [22273-09-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A

DPH1 ACAD10 UBE2D2 KCNH2

8.16e-051972746219_UP
DrugMephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; PC3; HT_HG-U133A

DPH1 FASTKD2 ACAD10 PAK6

8.49e-051992747384_UP
DrugLevocabastine hydrochloride [79547-78-7]; Down 200; 8.8uM; HL60; HT_HG-U133A

ACAD10 UBE2D2 UBE2D4 NDST2

8.65e-052002742948_DN
DrugN-methyl-DL-aspartic acid

PRKD2 ERBB3 RELN PDE2A PRKCQ PIK3C2G

9.79e-05655276CID000004376
DrugPkcs

PRKD2 ERBB3 PRKCQ PIK3C2G

1.06e-04211274CID000164073
DrugK00077

PRKD2 ERBB3 PRKCQ PIK3C2G

1.25e-04220274CID006419759
Drugacetyl-L-carnitine

PRKD2 PRKCQ ACAD10

1.33e-0484273CID000000001
DrugAC1L1G9T

PRKD2 ERBB3 UBE2D2 PIK3C2G KCNH2

1.39e-04433275CID000003591
DrugRK-1409B

PRKD2 PRKCQ

1.41e-0415272CID003036125
Drugdansyl-DAG

PRKD2 PRKCQ

1.41e-0415272CID000129493
Drug1-stearoyl-2-arachidonylglycerol

PRKD2 KCNH2

1.41e-0415272CID006443869
Drugdaphnoretin

PRKD2 PRKCQ

1.82e-0417272CID005281406
DrugAC1L1JQC

PRKD2 PRKCQ

1.82e-0417272CID000005157
Drugdihydrosterculic acid

PRKD2 PRKCQ

2.05e-0418272CID000160788
Drugcasticin

ZNF384 ERBB3 UBE2D3 KCNH2

2.10e-04252274ctd:C054133
DrugTAPP-Br

PRKD2 PRKCQ

2.29e-0419272CID000160326
Drugpalmitoylcarnitine

PRKD2 PRKCQ ACAD10

2.36e-04102273CID000000461
DrugPX-866

ERBB3 PIK3C2G

2.54e-0420272CID009849735
DrugKS-619-1

PRKD2 PRKCQ

2.80e-0421272CID000128369
DrugK-259-2

PRKD2 PRKCQ

2.80e-0421272CID006438946
Drugbroussochalcone A

PRKD2 PRKCQ

2.80e-0421272CID006438825
DrugAC1L1DXE

PRKD2 PRKCQ PIK3C2G NDST2

4.03e-04299274CID000002548
Drugbupivacaine

PRKD2 PRKCQ KCNH2

4.29e-04125273CID000002474
DrugAC1L1DKK

PRKD2 ERBB3 PIK3C2G

4.50e-04127273CID000002390
Drugpseudohypericin

PRKD2 PRKCQ

4.67e-0427272CID005281751
Drugaplysiatoxin

PRKD2 PRKCQ

5.02e-0428272CID000040465
DrugAMP group

PRKD2 PDE2A PRKCQ UBE2D2 UBE2D4

5.31e-04579275CID000000224
DrugPolychlorinated biphenyls

PRKD2 PRKCQ

5.39e-0429272CID000006636
Drug1-alpha-25-dihydroxycholecalciferol

PRKD2 ERBB3 PDE2A PRKCQ PAK6 XPO6

5.74e-04909276CID000002524
DrugIN1434

ERBB3 KCNH2

6.17e-0431272CID000002059
Drug9,11-octadecadienoic acid

PRKD2 ERBB3 PRKCQ

6.23e-04142273CID000074607
DrugZlllal

PRKD2 DPH1 PRKCQ UBE2D2 PIK3C2G

6.87e-04613275CID000107707
DrugAC1L1FGW

PRKD2 PRKCQ

6.99e-0433272CID000003231
Drugbarium

PRKD2 PRKCQ KCNH2

7.02e-04148273CID000104810
Drugchelerythrine

PRKD2 PDE2A PRKCQ PIK3C2G

7.84e-04357274CID000002703
Drugnorathyriol

PRKD2 PRKCQ

8.79e-0437272CID005281656
Drugbenzene

PRKD2 PRKCQ XPO6

9.79e-04166273CID000000241
DrugAC1L1KEH

PRKD2 KCNH2

1.03e-0340272CID000005462
Drugdigoxigenine

PRKD2 PRKCQ

1.03e-0340272CID000015478
Druglavendustin A

PRKD2 PIK3C2G KCNH2

1.07e-03171273CID000003894
Drugantibiotic from Streptomyces

PRKD2 PRKCQ

1.13e-0342272CID000005153
Drugbenzenesulfonate

PRKD2 PRKCQ

1.13e-0342272CID000007371
Drugcarbachol

PRKD2 ERBB3 PDE2A PRKCQ PIK3C2G

1.15e-03688275CID000002551
Diseaseazoospermia (implicated_via_orthology)

NDST4 NDST2

2.79e-0427272DOID:14227 (implicated_via_orthology)
DiseaseGastric Adenocarcinoma

PRKD2 ERBB3

7.79e-0445272C0278701
DiseaseIGFBP-3 measurement

ERBB3 PAK6

1.12e-0354272EFO_0004626
Diseasegrowth-regulated alpha protein measurement

FCRL5 PAK6

1.16e-0355272EFO_0008146
Diseasetype 1 diabetes mellitus

PRKD2 ERBB3 PRKCQ

1.38e-03242273MONDO_0005147
DiseaseMajor Depressive Disorder

SLC6A15 ERBB3 RELN

1.39e-03243273C1269683
DiseaseUnipolar Depression

SLC6A15 ERBB3 RELN

1.67e-03259273C0041696
Diseaseintellectual disability (implicated_via_orthology)

NDST4 NDST2

2.15e-0375272DOID:1059 (implicated_via_orthology)
DiseaseProstatic Neoplasms

NDST4 ERBB3 PAK6 NDST2

2.25e-03616274C0033578
DiseaseMalignant neoplasm of prostate

NDST4 ERBB3 PAK6 NDST2

2.25e-03616274C0376358
Diseasebody surface area

ERBB3 PDE2A ACAD10 KCNH2

2.63e-03643274EFO_0022196
Diseasehousehold income

SLC6A15 ERBB3 PDE2A

2.64e-03304273EFO_0009695
Diseaseatrial fibrillation

ACAD10 UBE2D3 KCNH2

4.61e-03371273EFO_0000275
DiseaseMalignant Neoplasms

ERBB3 KCNH2

6.10e-03128272C0006826
Diseasevenous thromboembolism

SLC6A15 RELN FASTKD2

8.34e-03460273EFO_0004286
Diseaserheumatoid arthritis

ERBB3 PDE2A PRKCQ

8.44e-03462273EFO_0000685
Diseaseautism spectrum disorder (implicated_via_orthology)

NDST4 NDST2

8.50e-03152272DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
YLNIQSWPPHMHNFS

ERBB3

396

P21860
QLYHTEMDFPASAWN

APOBEC4

156

Q8WW27
LPPTENWNFYMAFSF

ACAD10

541

Q6JQN1
SWQQPYPMDFYAGSS

DPH1

376

Q9BZG8
MAYSWQTDPNPNESH

PIK3C2G

1

O75747
HWATDPDMYLQSPQS

PAK6

121

Q9NQU5
FTFSDHYMDWVRQAP

IGHV3-72

46

A0A0B4J1Y9
TMYPPWDSTFDAHIN

PRKCQ

51

Q04759
FGSYNNHAWSFPSEP

NCR1

191

O76036
MAQHDFAPAWLNFPT

GPBP1

1

Q86WP2
VLDMYPEFSDHFWSS

KCNH2

841

Q12809
QFYHEDMPLWSSSTP

FCRL5

506

Q96RD9
RDPPYHNWMHAFSVS

PDE2A

651

O00408
IQNAAFMYPASPWSH

PRKD2

761

Q9BZL6
FYTPEAFNWRQAHMQ

DPP3

556

Q9NY33
DWYMDFFPTPSNTTS

NDST4

646

Q9H3R1
TWHLMDEFYFPQTTN

RELN

1891

P78509
YMNFSDPGPWSKVNH

CCDC73

901

Q6ZRK6
FTEAMTHFPASPFWS

SLC6A15

446

Q9H2J7
THFPASPFWSVMFFL

SLC6A15

451

Q9H2J7
APTFPSSNYFTAMWT

FASTKD2

176

Q9NYY8
FHWQATIMGPNDSPY

UBE2D2

31

P62837
MEESHFNSNPYFWPS

ZNF384

1

Q8TF68
FHWQATIMGPNDSPY

UBE2D3

31

P61077
WYMDFFPVPSNASTD

NDST2

656

P52849
HSRMAEPRFNNPYFW

ZNF362

11

Q5T0B9
FHWQATIMGPNDSPY

UBE2D4

31

Q9Y2X8
DWPMFYHDFFTNILQ

XPO6

121

Q96QU8
MPPDDDWRQSSYASH

USP54

1636

Q70EL1