Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoincreased circulating LDL cholesterol level

CT45A2 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A9

4.61e-1080327MP:0000182
MousePhenoabnormal circulating LDL cholesterol level

CT45A2 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A9

6.78e-08163327MP:0000181
MousePhenoabnormal circulating non-HDL cholesterol level

CT45A2 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A9

1.34e-07180327MP:0020151
MousePhenoincreased circulating HDL cholesterol level

CT45A2 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A9

8.89e-07238327MP:0001556
MousePhenoabnormal circulating HDL cholesterol level

CT45A2 CT45A6 CT45A1 MYZAP CT45A3 CT45A10 CT45A7 CT45A9

6.78e-06460328MP:0000184
MousePhenoabnormal circulating lipoprotein level

CT45A2 CT45A6 CT45A1 MYZAP CT45A3 CT45A10 CT45A7 CT45A9

1.98e-05533328MP:0010330
MousePhenoabnormal lipoprotein level

CT45A2 CT45A6 CT45A1 MYZAP CT45A3 CT45A10 CT45A7 CT45A9

1.98e-05533328MP:0010329
MousePhenoincreased circulating cholesterol level

CT45A2 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A9

6.85e-05463327MP:0005178
MousePhenoincreased cholesterol level

CT45A2 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A9

1.14e-04502327MP:0003982
MousePhenoincreased sterol level

CT45A2 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A9

1.18e-04505327MP:0012226
MousePhenoabnormal circulating cholesterol level

CT45A2 CT45A6 CT45A1 MYZAP CT45A3 CT45A10 CT45A7 CT45A9

4.14e-04823328MP:0000180
MousePhenoincreased lipid level

CT45A2 ANKRD26 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A9

5.02e-04847328MP:0014460
MousePhenoabnormal cholesterol level

CT45A2 CT45A6 CT45A1 MYZAP CT45A3 CT45A10 CT45A7 CT45A9

5.86e-04867328MP:0003947
MousePhenoabnormal sterol level

CT45A2 CT45A6 CT45A1 MYZAP CT45A3 CT45A10 CT45A7 CT45A9

6.47e-04880328MP:0012224
MousePhenoabnormal macrophage activation involved in immune response

SLFN11 SLFN13

6.76e-0417322MP:0011075
DomainINT_SG_DDX_CT_C

CT45A1 CT45A3 CT45A10 CT45A7 CT45A9

2.21e-128415PF15300
DomainINT_SG_DDX_CT_C

CT45A1 CT45A3 CT45A10 CT45A7 CT45A9

2.21e-128415IPR029307
Domain-

RLF ZSCAN9 ZNF407 ZNF276 ZNF28 ZNF148 ZNF230 ZNF317 KLF13 ZBTB1

1.52e-0667941103.30.160.60
Domainzf-C2H2

RLF ZSCAN9 ZNF407 ZNF276 ZNF28 ZNF148 ZNF230 ZNF317 KLF13 ZBTB1

1.83e-066934110PF00096
DomainZnf_C2H2/integrase_DNA-bd

RLF ZSCAN9 ZNF407 ZNF276 ZNF28 ZNF148 ZNF230 ZNF317 KLF13 ZBTB1

1.86e-066944110IPR013087
DomainZINC_FINGER_C2H2_2

RLF ZSCAN9 ZNF407 ZNF276 ZNF28 ZNF148 ZNF230 ZNF317 KLF13 ZBTB1

4.97e-067754110PS50157
DomainZINC_FINGER_C2H2_1

RLF ZSCAN9 ZNF407 ZNF276 ZNF28 ZNF148 ZNF230 ZNF317 KLF13 ZBTB1

5.09e-067774110PS00028
DomainRmlC_Cupin

CT45A2 CT45A1 CT45A3

5.39e-0616413IPR011051
DomainZnf_C2H2-like

RLF ZSCAN9 ZNF407 ZNF276 ZNF28 ZNF148 ZNF230 ZNF317 KLF13 ZBTB1

6.30e-067964110IPR015880
DomainZnf_C2H2

RLF ZSCAN9 ZNF407 ZNF276 ZNF28 ZNF148 ZNF230 ZNF317 KLF13 ZBTB1

6.95e-068054110IPR007087
DomainZnF_C2H2

RLF ZSCAN9 ZNF407 ZNF276 ZNF28 ZNF148 ZNF230 ZNF317 KLF13 ZBTB1

7.18e-068084110SM00355
DomainDUF2075

SLFN11 SLFN13

1.41e-053412IPR018647
DomainDUF2075

SLFN11 SLFN13

1.41e-053412PF09848
DomainAlbA_2

SLFN11 SLFN13

9.81e-057412PF04326
DomainSchlafen

SLFN11 SLFN13

9.81e-057412IPR029684
DomainSchlafen_AAA_dom

SLFN11 SLFN13

9.81e-057412IPR007421
Domain-

SHANK2 ARAP2 C19orf47

1.62e-031064131.10.150.50
DomainSAM/pointed

SHANK2 ARAP2 C19orf47

2.15e-03117413IPR013761
DomainZinc_finger_PHD-type_CS

BPTF NSD2

8.96e-0365412IPR019786
DomainSAM_1

SHANK2 ARAP2

9.77e-0368412PF00536
DomainPHD

BPTF NSD2

1.18e-0275412PF00628
Domain-

IPO5 RIPOR3 DAAM1

1.27e-022224131.25.10.10
DomainZnf_PHD-finger

BPTF NSD2

1.30e-0279412IPR019787
Pubmed

Identification of cancer/testis-antigen genes by massively parallel signature sequencing.

CT45A2 CT45A8 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A5 CT45A9

2.68e-231546915905330
Pubmed

Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.

SLFN11 SLFN13

1.71e-06246237833372
Pubmed

BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers.

SLFN11 RB1

1.71e-06246232075943
Pubmed

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.

SLFN11 SLFN13

1.71e-06246229563550
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

CT45A2 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CHST3 CT45A9

2.60e-0667446837196079
Pubmed

Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.

SLFN11 SLFN13

5.13e-06346238875319
Pubmed

Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.

SLFN11 SLFN13

1.71e-05546229528433
Pubmed

Subcellular localization of the Schlafen protein family.

SLFN11 SLFN13

1.71e-05546218355440
Pubmed

Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.

SLFN11 SLFN13

1.71e-05546224089532
Pubmed

Schlafen, a new family of growth regulatory genes that affect thymocyte development.

SLFN11 SLFN13

2.56e-0564629846487
Pubmed

Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.

SLFN11 SLFN13

3.58e-05746215351786
Pubmed

Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence.

SLFN11 SLFN13

4.77e-05846219619625
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

BPTF ZNF148 NSD2 EIF4G1 C19orf47

1.27e-0437046522922362
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

RLF IPO5 BPTF ZNF148 RB1 NSD2

1.44e-0460846636089195
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

CT45A2 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 ARAP2 CT45A9

2.02e-04124246830973865
Pubmed

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.

SHMT2 SLFN11 EIF4G1

2.75e-049546333863777
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ANKRD26 SHANK2 NSD2

3.59e-0410446310470851
Pubmed

DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.

DAAM1 RB1

5.45e-042646226526197
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

IPO5 SLFN11 RB1

6.73e-0412946323022380
Pubmed

Next-generation sequencing to generate interactome datasets.

MKRN3 SHMT2 CFAP206 ZNF276 ZNF317 CT45A3 CT45A5

7.25e-04114746721516116
Pubmed

Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.

RLF IPO5

9.35e-043446225505242
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

RLF IPO5 ZNF407 ZNF28 ZNF317 RB1 EIF4G1

9.58e-04120346729180619
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

ZSCAN9 ZNF407 ZNF276 KLF13 RB1 ZBTB1

1.00e-0387746620211142
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

IPO5 ZNF148 RB1 C19orf47

1.05e-0333946430415952
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

IPO5 DIXDC1 ZNF230

1.06e-0315146317043677
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

UNC13B RLF ZNF148 EIF4G1

1.32e-0336146426167880
CytobandEnsembl 112 genes in cytogenetic band chrXq26

CT45A2 CT45A8 CT45A6 CT45A1 SAGE2P CT45A3 CT45A10 CT45A7 CT45A5 CT45A9

1.43e-151714610chrXq26
CytobandXq26.3

CT45A2 CT45A6 CT45A1 SAGE2P CT45A3 CT45A5

6.87e-1167466Xq26.3
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

RLF ZSCAN9 ZNF407 ZNF276 ZNF28 ZNF148 ZNF230 ZNF317 KLF13 ZBTB1

2.73e-08718261028
GeneFamilySchlafen family

SLFN11 SLFN13

4.16e-0572621110
GeneFamilyAnkyrin repeat domain containing

ANKRD26 SHANK2 ARAP2

4.91e-03242263403
GeneFamilySterile alpha motif domain containing

SHANK2 ARAP2

7.06e-0388262760
GeneFamilyPHD finger proteins

BPTF NSD2

7.37e-039026288
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_1_CELL

CT45A2 CT45A8 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A5 CT45A9

2.90e-1569459M45681
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_2_CELL

CT45A2 CT45A8 CT45A6 CT45A1 CT45A3 CT45A10 CT45A7 CT45A5 CT45A9

1.35e-13104459M45682
CoexpressionAtlasFacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_500_k-means-cluster#4

UNC13B DAAM1 KLF13 RB1

4.59e-0598434Facebase_RNAseq_e10.5_Olfactory Pit_500_K4
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CT45A2 CT45A6 CT45A1 CT45A10 CT45A5 CT45A9

1.04e-08157446b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CT45A2 CT45A6 CT45A1 CT45A10 CT45A5 CT45A9

1.67e-08170446fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CT45A2 CT45A6 CT45A1 CT45A10 CT45A5 CT45A9

3.24e-08190446d24af6af3271e34afab744352afd28be8a7cc5c3
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CT45A2 CT45A6 CT45A1 CT45A10 CT45A5 CT45A9

3.24e-0819044671a00f63fdd4eb4cc6f190d37e7a0417cdaafacb
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CT45A2 CT45A6 CT45A1 CT45A10 CT45A5 CT45A9

3.55e-081934462f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CT45A2 CT45A6 CT45A1 CT45A10 CT45A9

5.19e-071604455cd4fbbd2ce671a8377416eff94041a111375dee
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IPO5 CFAP206 SLFN13 NSD2

1.78e-05158444d72d6527dc50207ddbada262460d3c4bac249a19
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SCFD2 NMNAT2 SLFN13 CT45A10

3.82e-05192444c4efc170852abbcf0c53c2b0f8a0cc9fe7f116c8
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SCFD2 NMNAT2 SLFN13 CT45A10

3.82e-051924444c9d748f209cc1e13d28c8c7f5180ab8522e0fbf
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MKRN3 CFAP206 SHANK2 MYZAP

4.14e-051964447e98380d815fbf6254289ace2af37aac6fef51e8
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BPTF ZNF407 SLFN13 ARAP2

4.39e-05199444f0b0097df0026496470a80d8cc9375ffd8389b00
ComputationalNeighborhood of BUB1B

IPO5 SHMT2 NSD2

2.34e-0466203MORF_BUB1B
DiseaseCOVID-19, mortality

SCFD2 SHANK2 CHST3

1.07e-03170353EFO_0004352, MONDO_0100096
Diseasehippocampal CA1 volume

SCFD2 DAAM1

1.49e-0348352EFO_0009394
DiseaseL2 Acute Lymphoblastic Leukemia

RB1 NSD2

1.62e-0350352C0023453
DiseaseChildhood Acute Lymphoblastic Leukemia

RB1 NSD2

1.75e-0352352C0023452
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

RB1 NSD2

2.39e-0361352C1961102
Diseaseschizophrenia (implicated_via_orthology)

SHMT2 CHST3

2.96e-0368352DOID:5419 (implicated_via_orthology)
DiseaseManic Disorder

DIXDC1 SHANK2

3.23e-0371352C0024713
DiseaseManic

DIXDC1 SHANK2

3.88e-0378352C0338831
DiseaseDepression, Bipolar

DIXDC1 SHANK2

3.98e-0379352C0005587
Diseaseestradiol measurement

ZNF407 SHANK2

7.56e-03110352EFO_0004697
DiseaseR-6-hydroxywarfarin measurement

NWD1 SHANK2

8.10e-03114352EFO_0803327

Protein segments in the cluster

PeptideGeneStartEntry
ERQRKIELHVKHMCK

BHLHB9

396

Q6PI77
ILKHAKVVHRQDMCK

C19orf47

101

Q8N9M1
ELEHKDVLLAHCMKR

DIXDC1

461

Q155Q3
IKEAARCMRRDFVKH

CT45A5

166

P0DMU8
KERASMVAHCLEHKD

ARAP2

1606

Q8WZ64
MVAHCLEHKDDKLRN

ARAP2

1611

Q8WZ64
FQKMLIDERLRCEHH

CEP83

31

Q9Y592
RHTEAVRCAEKMQDH

ANKRD26

1276

Q9UPS8
LCKILEEMREEIHRH

BPTF

516

Q12830
IKEAARCMRRDFVKH

CT45A7

166

P0DMV0
KTDVCRMKEHMEDRV

CFAP206

376

Q8IYR0
HKHILEDCALRMVDR

NWD1

196

Q149M9
NLTREMIKHLERCEH

RB1

541

P06400
RMREVCDEVKAHLLA

SHMT2

236

P34897
IKEAARCMRRDFVKH

CT45A10

166

P0DMU9
IKEAARCMRRDFVKH

CT45A3

166

Q8NHU0
LIDEEECMARIKHAH

NSD2

1096

O96028
EMHEAIKHEDPCAKR

IPO5

1046

O00410
EHKHELDRMAKADRF

DAAM1

746

Q9Y4D1
IKEAARCMRRDFVKH

CT45A1

166

Q5HYN5
IKEAARCMRRDFVKH

CT45A9

166

P0DMV2
IKEAARCMRRDFVKH

CT45A2

166

Q5DJT8
HKEAEMEEHREHIKV

EIF4G1

1006

Q04637
IKEAARCMRRDFVKH

CT45A8

166

P0DMV1
ICEKRFMRSDHLTKH

KLF13

231

Q9Y2Y9
RHEVKTIDMRFRIHC

CCDC168

5496

Q8NDH2
KIMEKIRNVFHCEAH

SLFN13

611

Q68D06
IKEAARCMRRDFVKH

CT45A6

166

P0DMU7
KIMEKIRNVFHCEAH

SLFN11

611

Q7Z7L1
EHRKIEECVKMAHRA

MRPS18A

111

Q9NVS2
KHKEAVMEVRRHLVE

SCFD2

351

Q8WU76
KCMDHIQHRLVEKIT

SHANK2

166

Q9UPX8
AEACRRKEHMALKAV

CHST3

261

Q7LGC8
QREEHMRACIEAHEK

MKRN3

281

Q13064
KRECIEARILHHSKM

RLF

561

Q13129
QTRCVERHIRKMEFH

RIPOR3

121

Q96MK2
ERHIRKMEFHISKVD

RIPOR3

126

Q96MK2
EIDSHCHLRKVKHMR

SAGE2P

596

A6NJ88
MKKHIKEHHEEVRER

ZNF276

451

Q8N554
HLSKLKDHMVREETR

UNC13B

1331

O14795
IMEENERDHRRKHFC

ZBTB1

566

Q9Y2K1
HQRVHLREKLSKCDM

ZNF230

186

Q9UIE0
CEKVFSRKSHMERHR

ZNF28

556

P17035
MVAHRHRQEVLCKEM

ZSCAN9

141

O15535
RTDRVLKHKRMCHEN

ZNF148

266

Q9UQR1
TDLEIHVKRCHAREM

ZNF407

541

Q9C0G0
RHMSVHLVKKRVECR

ZNF317

491

Q96PQ6
ERIRHLDDMVHCQQK

MYZAP

351

P0CAP1
CSVLEHHRDLMKRVT

NMNAT2

96

Q9BZQ4