Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of cardiac muscle cell apoptotic process	ADCY10 HMGCR MAPK8	4.92e-05	32	46	3	GO:0010666
GeneOntologyBiologicalProcess	positive regulation of striated muscle cell apoptotic process	ADCY10 HMGCR MAPK8	5.40e-05	33	46	3	GO:0010663
Domain	MKRN1_C	MKRN3 MKRN1	5.68e-06	2	45	2	PF15815
Domain	MKRN1_C	MKRN3 MKRN1	5.68e-06	2	45	2	IPR031644
Domain	ABC_transporter_CS	ABCC1 ABCA4 ABCA5	1.40e-04	42	45	3	IPR017871
Domain	ABC_tran	ABCC1 ABCA4 ABCA5	2.10e-04	48	45	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCC1 ABCA4 ABCA5	2.10e-04	48	45	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCC1 ABCA4 ABCA5	2.23e-04	49	45	3	PS00211
Domain	ABC_transporter-like	ABCC1 ABCA4 ABCA5	2.37e-04	50	45	3	IPR003439
Domain	ABC_A	ABCA4 ABCA5	3.69e-04	12	45	2	IPR026082
Domain	AAA+_ATPase	RAD51B ABCC1 ABCA4 ABCA5	3.95e-04	144	45	4	IPR003593
Domain	AAA	RAD51B ABCC1 ABCA4 ABCA5	3.95e-04	144	45	4	SM00382
Domain	SSD	DISP2 HMGCR	4.35e-04	13	45	2	IPR000731
Domain	SSD	DISP2 HMGCR	4.35e-04	13	45	2	PS50156
Domain	ACR	ADAMTS19 ADAM12	1.92e-03	27	45	2	SM00608
Domain	ADAM_Cys-rich	ADAMTS19 ADAM12	1.92e-03	27	45	2	IPR006586
Domain	Peptidase_M12B_N	ADAMTS19 ADAM12	3.97e-03	39	45	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS19 ADAM12	3.97e-03	39	45	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS19 ADAM12	4.18e-03	40	45	2	PS00427
Domain	Reprolysin	ADAMTS19 ADAM12	4.18e-03	40	45	2	PF01421
Domain	-	MKRN3 MKRN1	4.18e-03	40	45	2	4.10.1000.10
Domain	ADAM_MEPRO	ADAMTS19 ADAM12	4.18e-03	40	45	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS19 ADAM12	4.18e-03	40	45	2	PS50214
Domain	Peptidase_M12B	ADAMTS19 ADAM12	4.18e-03	40	45	2	IPR001590
Domain	Disintegrin_dom	ADAMTS19 ADAM12	4.38e-03	41	45	2	IPR001762
Domain	ZnF_C3H1	MKRN3 MKRN1	5.97e-03	48	45	2	SM00356
Domain	zf-CCCH	MKRN3 MKRN1	6.21e-03	49	45	2	PF00642
Pubmed	Diverse Targets of β-Catenin during the Epithelial-Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse.	ABCC1 ABCA4 ABCA5	2.06e-07	9	48	3	26122848
Pubmed	JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis.	MAPK8 BBC3	1.87e-06	2	48	2	19638343
Pubmed	HMG-CoA reductase inhibition reduces the proinflammatory activation of human vascular smooth muscle cells by the terminal complement factor C5b-9.	HMGCR C5	1.87e-06	2	48	2	14556080
Pubmed	Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways.	ABCC1 MAPK8	5.59e-06	3	48	2	20051532
Pubmed	P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK.	MAPK8 BBC3	5.59e-06	3	48	2	22283740
Pubmed	PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.	MAPK8 BBC3	5.59e-06	3	48	2	21725994
Pubmed	Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma.	MAPK8 BBC3	5.59e-06	3	48	2	28445976
Pubmed	JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells.	MAPK8 BBC3	1.12e-05	4	48	2	22394200
Pubmed	HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier.	ABCC1 MAPK8	1.12e-05	4	48	2	16395283
Pubmed	Integrative predictive model of coronary artery calcification in atherosclerosis.	ABCC1 HMGCR C5 ABCA4 VCAM1	1.61e-05	229	48	5	19948975
Pubmed	Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice.	ABCA4 MAPK8	1.86e-05	5	48	2	32265302
Pubmed	Involvement of MAPKs and NF-kappaB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells.	MAPK8 VCAM1	2.79e-05	6	48	2	17303384
Pubmed	Mapping of the mouse Ly-6, Xp-14, and Gdc-1 loci to chromosome 15.	SLC45A2 C5	3.90e-05	7	48	2	2880797
Pubmed	Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death.	C5 MAPK8	3.90e-05	7	48	2	19864026
Pubmed	Nox2-based NADPH oxidase mediates HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 and subsequent monocyte adhesion in human astrocytes.	MAPK8 VCAM1	5.19e-05	8	48	2	21172429
Pubmed	Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.	BBC3 TFDP1	6.67e-05	9	48	2	25940086
Pubmed	A genome-wide scan for breast cancer risk haplotypes among African American women.	RAD51B BCAS3	6.67e-05	9	48	2	23468962
Pubmed	Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm.	ADCY10 TEX101	1.02e-04	11	48	2	19144954
Pubmed	Suppression of HIV-1 Tat-induced monocyte adhesiveness by a cell-permeable superoxide dismutase in astrocytes.	MAPK8 VCAM1	1.22e-04	12	48	2	18160848
Pubmed	p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease.	MAPK8 BBC3	1.68e-04	14	48	2	18786355
Pubmed	Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes.	MAPK8 VCAM1	1.94e-04	15	48	2	25064159
Pubmed	HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes.	MAPK8 VCAM1	1.94e-04	15	48	2	26031809
Pubmed	A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.	CLDN7 VCAM1	2.21e-04	16	48	2	23610556
Pubmed	A protein interaction landscape of breast cancer.	RAD51B ABCC1 DDX50 ACO2 TFDP1 UBR4	2.29e-04	634	48	6	34591612
Pubmed	Variation in the lymphotoxin-alpha/tumor necrosis factor locus modifies risk of erythema nodosum in sarcoidosis.	C5 VCAM1	3.14e-04	19	48	2	19225544
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	ABCC1 WDR36 INTS3 RCC2 ACO2 UBR4	4.23e-04	711	48	6	33022573
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCA4 ABCA5	4.23e-04	22	48	2	8894702
Pubmed	Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice.	SLC5A12 KDSR	4.23e-04	22	48	2	22837474
Pubmed	Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.	MAPK8 BBC3	4.63e-04	23	48	2	30655546
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	KDSR UGCG	6.40e-04	27	48	2	23096701
Pubmed	Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function.	CLDN7 MAPK8	7.39e-04	29	48	2	34267243
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DIP2A DISP2 CLDN7 MEGF8 BCAS3 UBR4 KSR2	7.57e-04	1105	48	7	35748872
Pubmed	Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay.	C5 VCAM1	9.58e-04	33	48	2	19028820
Pubmed	Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism.	C5 VCAM1	1.02e-03	34	48	2	20603037
Pubmed	Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex.	C5 TFDP1	1.02e-03	34	48	2	25391964
Pubmed	Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.	KDSR UGCG	1.20e-03	37	48	2	29044125
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	DPY19L4 ABCC1 NELL2 HMGCR MEGF8 KDSR ADAM12	1.23e-03	1201	48	7	35696571
GeneFamily	ATP binding cassette subfamily A	ABCA4 ABCA5	2.56e-04	14	31	2	805
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAD51B ADAM12 NPFFR1 VCAM1 UGCG	1.44e-06	180	48	5	f103e161e966c257eac97e1b30a461c4ed9cafc2
Disease	urea measurement	SLC45A2 BCAS3	1.11e-04	10	47	2	EFO_0011005
Disease	xanthine measurement	RAD51B KSR2	1.92e-04	13	47	2	EFO_0010548
Disease	Malignant neoplasm of breast	RAD51B MROH7 ADAMTS19 ABCC1 ABCA4 ADAM12 ACO2 UBR4	2.67e-04	1074	47	8	C0006142
Disease	chronic obstructive pulmonary disease (is_marker_for)	ABCC1 C5 MAPK8	5.03e-04	97	47	3	DOID:3083 (is_marker_for)
Disease	cytotoxicity measurement, response to metformin	AQP12A SV2B	5.12e-04	21	47	2	EFO_0006952, GO_1901558
Disease	chronic kidney disease (biomarker_via_orthology)	HMGCR VCAM1	9.14e-04	28	47	2	DOID:784 (biomarker_via_orthology)
Disease	intraocular pressure measurement	RAD51B ABCA4 TTC41P ADAM12 BCAS3	1.26e-03	509	47	5	EFO_0004695
Disease	disease recurrence, unipolar depression, bipolar disorder, schizophrenia, sex interaction measurement	ADAMTS19 ADAM12	1.27e-03	33	47	2	EFO_0003761, EFO_0004952, EFO_0008343, MONDO_0004985, MONDO_0005090
Disease	Hypercholesterolemia	HMGCR VCAM1	1.77e-03	39	47	2	C0020443
Disease	cannabis dependence measurement	DIP2A ACO2	2.67e-03	48	47	2	EFO_0008457

Protein segments in the cluster

Peptide	Gene	Start	Entry
ISQGMLKCVGSSMFL	ABCA5	686	Q8WWZ7
SCTGMATICNMGAEI	ACO2	276	Q99798
QGLGMQAACTLMRLC	AQP12A	106	Q8IXF9
AIMVKGAFRCMGTIQ	ABCA4	2141	P78363
MKFGMGSAQACPCQV	BBC3	1	Q96PG8
LISGGKDSCYNMMQC	DPH6	6	Q7L8W6
GCSCQMAVEKGGCIM	ADAM12	366	O43184
TEKVMFGMACLICNR	ADCY10	466	Q96PN6
EKPVCCMAFNTSGML	BCAS3	351	Q9H6U6
ILMMVKCVSCGFASF	DISP2	1091	A7MBM2
KCSVMFIGSLVPCME	MROH7	1216	Q68CQ1
GCGKTQFCIMMSILA	RAD51B	111	O15315
CGAEFSMIMDCKGNL	RCC2	261	Q9P258
SMIMDCKGNLYSFGC	RCC2	266	Q9P258
ITCGKGMQSRVIQCM	ADAMTS19	1101	Q8TE59
GVLGADGVCMTFMKQ	INTS3	156	Q68E01
MLKCVMSGSQVKVFG	RAD9B	1	Q6WBX8
FDNATCKMSGLVQGM	NPFFR1	111	Q9GZQ6
MFIKVMFGAGCSVLV	C22orf15	1	Q8WYQ4
MCVNTPGSFMCICKT	NELL2	456	Q99435
GVRQLEIMCCFGCMS	HMGCR	186	P04035
MSQTCTVCGKGMLFG	KSR2	421	Q6VAB6
VGCIMGEMVCHKILF	MAPK8	211	P45983
CKTGYTMDNMTGLCR	MEGF8	2206	Q7Z7M0
SSLAMFTCLCGMAGN	MRGPRD	31	Q8TDS7
MLAGCGAGMCQVVVT	SLC25A18	106	Q9H1K4
SGMQFCVKMSAVEGI	C5	851	P01031
TRMCLLKGNMGVCFD	DDX50	621	Q9BQ39
KIFIGCLAAVTSGMM	DPY19L4	51	Q7Z388
NVTGFKCVTGMSCLM	UGCG	201	Q16739
CSYSVMEMCTKGLGA	DIP2A	1246	Q14689
CTIMMKAQAASGICT	CFAP69	231	A5D8W1
GKGMDCATLTCMVQL	SLC45A2	471	Q9UMX9
DMLVNCAGMAVSGKF	KDSR	116	Q06136
FAVQRSKDMVCGICM	MKRN1	271	Q9UHC7
IKMFMGSLFNVIGAC	ABCC1	1091	P33527
QIGDSVMLTCSVMGC	VCAM1	326	P19320
LKMIGGSMLISAVCC	SV2B	566	Q7L1I2
LLCGMEAGVQASCMQ	SNPH	296	O15079
FVATMGMKCTRCGGD	CLDN7	96	O95471
KRMGMACGLESGSCS	TFDP1	301	Q14186
TKGNRFILCCMASLM	TMEM269	161	A0A1B0GVZ9
ECGECGKFFRMKMTL	ZNF157	331	P51786
FAVQRGMDKVCGICM	MKRN3	301	Q13064
EVKGCTAMIGCRLMS	TEX101	181	Q9BY14
MKMSGCLRGLCGFLS	TTC41P	726	Q6P2S7
SKGLCLLFGVMCTSM	SLC5A12	381	Q1EHB4
MQTCSGKGIKMAFLD	nan	1	Q6ZS46
AGVMAQCGGLECMLN	UBR4	4476	Q5T4S7
CGGSIEVMQSFLKMI	WDR36	866	Q8NI36