Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionretinoic acid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.48e-0828204GO:0001972
GeneOntologyMolecularFunctionglucuronosyltransferase activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.76e-0835204GO:0015020
GeneOntologyMolecularFunctionretinoid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.38e-0748204GO:0005501
GeneOntologyMolecularFunctionisoprenoid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.51e-0749204GO:0019840
GeneOntologyMolecularFunctionprotein kinase C binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.07e-0766204GO:0005080
GeneOntologyMolecularFunctionfatty acid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.07e-0769204GO:0005504
GeneOntologyMolecularFunctioncarboxylic acid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7 GRIN3B

3.15e-06239205GO:0031406
GeneOntologyMolecularFunctionmonocarboxylic acid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.53e-06107204GO:0033293
GeneOntologyMolecularFunctionorganic acid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7 GRIN3B

4.25e-06254205GO:0043177
GeneOntologyMolecularFunctionsteroid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.39e-06133204GO:0005496
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.46e-05153204GO:0008194
GeneOntologyMolecularFunctionhexosyltransferase activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.14e-05211204GO:0016758
GeneOntologyMolecularFunctionglycosyltransferase activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.71e-04288204GO:0016757
GeneOntologyMolecularFunctionprotein heterodimerization activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.85e-04398204GO:0046982
GeneOntologyMolecularFunctionenzyme inhibitor activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.16e-04435204GO:0004857
GeneOntologyMolecularFunctionmolecular function inhibitor activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.60e-03596204GO:0140678
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF675 HIVEP3 ISL2 ZNF492 ZBTB33

7.19e-031271205GO:0000987
GeneOntologyMolecularFunctionprotein homodimerization activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.91e-03815204GO:0042803
GeneOntologyMolecularFunctionprotein kinase binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.00e-02873204GO:0019901
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF675 HIVEP3 ISL2 ZNF492 ZBTB33

1.11e-021412205GO:0000981
GeneOntologyBiologicalProcessestrogen catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.97e-125214GO:0006711
GeneOntologyBiologicalProcessflavone metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.19e-116214GO:0051552
GeneOntologyBiologicalProcessphenylpropanoid catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.19e-116214GO:0046271
GeneOntologyBiologicalProcesscoumarin catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.19e-116214GO:0046226
GeneOntologyBiologicalProcesscoumarin metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.66e-1010214GO:0009804
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.66e-1010214GO:0009698
GeneOntologyBiologicalProcessflavonoid metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.64e-1013214GO:0009812
GeneOntologyBiologicalProcesscellular glucuronidation

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.70e-0921214GO:0052695
GeneOntologyBiologicalProcesshormone catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.70e-0921214GO:0042447
GeneOntologyBiologicalProcessflavonoid glucuronidation

UGT1A9 UGT1A8 UGT1A7

9.08e-095213GO:0052696
GeneOntologyBiologicalProcessglucuronate metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.17e-0826214GO:0019585
GeneOntologyBiologicalProcessuronic acid metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.17e-0826214GO:0006063
GeneOntologyBiologicalProcesssteroid catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.61e-0834214GO:0006706
GeneOntologyBiologicalProcessxenobiotic glucuronidation

UGT1A9 UGT1A8 UGT1A7

1.99e-0712213GO:0052697
GeneOntologyBiologicalProcessestrogen metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0752214GO:0008210
GeneOntologyBiologicalProcesssecondary metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.84e-0767214GO:0019748
GeneOntologyBiologicalProcesspigment metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.28e-0694214GO:0042440
GeneOntologyBiologicalProcessretinoic acid metabolic process

UGT1A9 UGT1A8 UGT1A7

8.77e-0640213GO:0042573
GeneOntologyBiologicalProcessxenobiotic metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.14e-05141214GO:0006805
GeneOntologyBiologicalProcessliver development

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.69e-05202214GO:0001889
GeneOntologyBiologicalProcesshepaticobiliary system development

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.97e-05205214GO:0061008
GeneOntologyBiologicalProcesscellular response to xenobiotic stimulus

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.77e-05222214GO:0071466
GeneOntologyBiologicalProcessretinoid metabolic process

UGT1A9 UGT1A8 UGT1A7

9.76e-0589213GO:0001523
GeneOntologyBiologicalProcessditerpenoid metabolic process

UGT1A9 UGT1A8 UGT1A7

1.15e-0494213GO:0016101
GeneOntologyBiologicalProcessterpenoid metabolic process

UGT1A9 UGT1A8 UGT1A7

1.59e-04105213GO:0006721
GeneOntologyBiologicalProcesshormone metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.80e-04286214GO:0042445
GeneOntologyBiologicalProcessisoprenoid metabolic process

UGT1A9 UGT1A8 UGT1A7

4.04e-04144213GO:0006720
GeneOntologyBiologicalProcesssteroid metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.09e-04376214GO:0008202
GeneOntologyBiologicalProcesslipid catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.40e-04382214GO:0016042
GeneOntologyBiologicalProcesssingle fertilization

ADCY3 WEE2 LY6K

1.19e-03209213GO:0007338
GeneOntologyBiologicalProcessresponse to xenobiotic stimulus

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.76e-03525214GO:0009410
GeneOntologyBiologicalProcessgland development

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.20e-03558214GO:0048732
GeneOntologyBiologicalProcesscilium movement

MEGF8 ADCY3 LY6K

2.25e-03261213GO:0003341
GeneOntologyBiologicalProcessfertilization

ADCY3 WEE2 LY6K

2.30e-03263213GO:0009566
DomainUDPGT

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.53e-0921194PS00375
DomainUDPGT

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.53e-0921194PF00201
DomainUDP_glucos_trans

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.53e-0921194IPR002213
Domain-

ZNF675 HIVEP3 ZNF492 ZBTB33

4.34e-036791943.30.160.60
Domainzf-C2H2

ZNF675 HIVEP3 ZNF492 ZBTB33

4.67e-03693194PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF675 HIVEP3 ZNF492 ZBTB33

4.69e-03694194IPR013087
DomainZINC_FINGER_C2H2_2

ZNF675 HIVEP3 ZNF492 ZBTB33

6.93e-03775194PS50157
DomainZINC_FINGER_C2H2_1

ZNF675 HIVEP3 ZNF492 ZBTB33

6.99e-03777194PS00028
DomainZnf_C2H2-like

ZNF675 HIVEP3 ZNF492 ZBTB33

7.61e-03796194IPR015880
DomainZnf_C2H2

ZNF675 HIVEP3 ZNF492 ZBTB33

7.91e-03805194IPR007087
DomainZnF_C2H2

ZNF675 HIVEP3 ZNF492 ZBTB33

8.01e-03808194SM00355
PathwayWP_ESTROGEN_METABOLISM

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.00e-0922164MM15888
PathwayREACTOME_GLUCURONIDATION

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.16e-0824164MM14599
PathwayWP_GLUCURONIDATION

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.38e-0825164MM15820
PathwayREACTOME_GLUCURONIDATION

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.38e-0825164M17787
PathwayKEGG_ASCORBATE_AND_ALDARATE_METABOLISM

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.38e-0825164M605
PathwayWP_GLUCURONIDATION

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.63e-0826164M39404
PathwayKEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.23e-0828164M19580
PathwayREACTOME_PARACETAMOL_ADME

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.89e-0839164MM15695
PathwayKEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.09e-0741164M7399
PathwayREACTOME_ASPIRIN_ADME

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.60e-0745164MM15694
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.68e-0751164M17726
PathwayKEGG_STARCH_AND_SUCROSE_METABOLISM

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.90e-0752164M14171
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.64e-0755164M14933
PathwayWP_CODEINE_AND_MORPHINE_METABOLISM

UGT1A9 UGT1A10 UGT1A8

4.33e-0714163M39328
PathwayKEGG_RETINOL_METABOLISM

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.75e-0764164M9488
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.70e-0770164M16794
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.09e-0672164M9257
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.32e-06107164MM14595
PathwayREACTOME_DRUG_ADME

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.73e-06109164M45012
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.73e-06109164M18788
PathwayREACTOME_DRUG_ADME

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.12e-06119164MM15692
PathwayREACTOME_ASPIRIN_ADME

UGT1A9 UGT1A8 UGT1A7

1.54e-0544163M45014
PathwayWP_2Q37_COPY_NUMBER_VARIATION_SYNDROME

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.78e-05145164M45512
PathwayWP_METAPATHWAY_BIOTRANSFORMATION

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.19e-05153164MM15844
PathwayWP_IRINOTECAN_PATHWAY

UGT1A9 UGT1A10

7.92e-0512162M39611
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.91e-05219164MM14838
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.07e-05220164M10320
PathwayWP_TAMOXIFEN_METABOLISM

UGT1A10 UGT1A8

2.50e-0421162M39631
PathwayWP_ESTROGEN_METABOLISM_WP5276

UGT1A10 UGT1A8

3.29e-0424162M46445
PathwayREACTOME_PARACETAMOL_ADME

UGT1A9 UGT1A10

4.82e-0429162M45015
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

UGT1A9 UGT1A10 UGT1A7

1.06e-03183163M39588
PathwayWP_ARYL_HYDROCARBON_RECEPTOR_PATHWAY_WP2873

UGT1A9 UGT1A7

1.16e-0345162M39615
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

UGT1A9 UGT1A7 FKBP5

4.94e-03314163M39428
Pubmed

Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.47e-12621420297805
Pubmed

Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.47e-12621432527940
Pubmed

Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.43e-1272148467709
Pubmed

Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.43e-1272148464825
Pubmed

Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.43e-12721427514509
Pubmed

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.86e-12821417179145
Pubmed

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.86e-12821418052087
Pubmed

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.86e-12821420610558
Pubmed

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.23e-11921422511988
Pubmed

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.06e-111021423642732
Pubmed

UDP-glucuronosyltransferases.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.06e-111021411465080
Pubmed

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.06e-111021423371916
Pubmed

A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.06e-111021422558097
Pubmed

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.85e-111221419419973
Pubmed

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.85e-111221420308471
Pubmed

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.85e-111221411434514
Pubmed

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.00e-111321422085899
Pubmed

Genome-wide analysis of hepatic lipid content in extreme obesity.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.00e-111321425246029
Pubmed

Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.79e-111421421646302
Pubmed

Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.79e-111421414672974
Pubmed

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.79e-11142149295054
Pubmed

Human UDP-glucuronosyltransferases: metabolism, expression, and disease.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.79e-111421410836148
Pubmed

Genome-wide association meta-analysis for total serum bilirubin levels.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.78e-101621419414484
Pubmed

Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region.

UGT1A9 UGT1A10 UGT1A8

1.90e-10321312847094
Pubmed

Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.

UGT1A9 UGT1A10 UGT1A8

1.90e-10321329519853
Pubmed

Genome-wide association of serum bilirubin levels in Korean population.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.33e-101721420639394
Pubmed

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.99e-101821420056724
Pubmed

A genome-wide assessment of variability in human serum metabolism.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.78e-101921423281178
Pubmed

Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28.

UGT1A9 UGT1A10 UGT1A7

7.59e-10421317558305
Pubmed

Genetic determinants influencing human serum metabolome among African Americans.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.04e-092421424625756
Pubmed

Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele.

UGT1A9 UGT1A8 UGT1A7

1.90e-09521320565459
Pubmed

Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.

UGT1A9 UGT1A10 UGT1A8

1.90e-09521315057901
Pubmed

Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.

UGT1A9 UGT1A10 UGT1A8

1.59e-08921320732626
Pubmed

Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients.

UGT1A9 UGT1A8 UGT1A7

3.12e-081121318695635
Pubmed

Human metabolic individuality in biomedical and pharmaceutical research.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.80e-085721421886157
Pubmed

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.91e-086621419898482
Pubmed

Discovery and refinement of loci associated with lipid levels.

UGT1A9 UGT1A10 UGT1A8 UGT1A7 KAT5

1.47e-0721121524097068
Pubmed

Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene.

UGT1A9 UGT1A7

3.47e-07221211677206
Pubmed

Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.

UGT1A9 UGT1A10

3.47e-07221222031623
Pubmed

Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon.

UGT1A10 UGT1A8

3.47e-0722129647757
Pubmed

Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.

UGT1A9 UGT1A7

3.47e-07221217529886
Pubmed

Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10.

UGT1A10 UGT1A8

3.47e-07221210497143
Pubmed

Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors.

UGT1A9 UGT1A8

3.47e-07221218568343
Pubmed

How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10?

UGT1A9 UGT1A10

3.47e-07221220089735
Pubmed

Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues.

UGT1A10 UGT1A8

3.47e-07221211901093
Pubmed

Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes.

UGT1A10 UGT1A8

3.47e-07221217603215
Pubmed

UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.

UGT1A9 UGT1A7

3.47e-07221215709193
Pubmed

Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs.

UGT1A9 UGT1A7

3.47e-07221212944498
Pubmed

Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.

UGT1A9 UGT1A10

3.47e-07221225547628
Pubmed

Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.

UGT1A9 UGT1A10

1.04e-06321220007669
Pubmed

UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients.

UGT1A9 UGT1A8

1.04e-06321219225446
Pubmed

Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1α and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid.

UGT1A9 UGT1A8

1.04e-06321223721685
Pubmed

Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites.

UGT1A10 UGT1A8

1.04e-06321219244109
Pubmed

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions.

UGT1A8 UGT1A7

1.04e-06321219996319
Pubmed

[Influence of genetic polymorphisms in UGT1A1, UGT1A7 and UGT1A9 on the pharmacokynetics of irinotecan, SN-38 and SN-38G].

UGT1A9 UGT1A7

1.04e-06321223789755
Pubmed

Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9.

UGT1A9 UGT1A8

1.04e-06321226247833
Pubmed

Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.

UGT1A9 UGT1A8

1.04e-06321216397224
Pubmed

Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.

UGT1A9 UGT1A7

1.04e-06321219364970
Pubmed

Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer.

UGT1A9 UGT1A7

1.04e-06321217406868
Pubmed

The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers.

UGT1A9 UGT1A8

1.04e-06321217339869
Pubmed

Differences in UGT1A1, UGT1A7, and UGT1A9 polymorphisms between Uzbek and Japanese populations.

UGT1A9 UGT1A7

1.04e-06321224453052
Pubmed

Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin.

UGT1A9 UGT1A7

1.04e-06321216636344
Pubmed

Genetic polymorphisms of UGT1A8, UGT1A9, UGT2B7 and ABCC2 in Chinese renal transplant recipients and a comparison with other ethnic populations.

UGT1A9 UGT1A8

2.08e-06421223700788
Pubmed

Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1.

UGT1A9 UGT1A10

2.08e-0642122108603
Pubmed

Influence of uridine diphosphate (UDP)-glucuronosyltransferases and ABCC2 genetic polymorphisms on the pharmacokinetics of mycophenolic acid and its metabolites in Chinese renal transplant recipients.

UGT1A9 UGT1A8

2.08e-06421218946804
Pubmed

Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.

UGT1A10 UGT1A7

2.08e-0642129271343
Pubmed

Population pharmacokinetics and pharmacogenetics of mycophenolic acid following administration of mycophenolate mofetil in de novo pediatric renal-transplant patients.

UGT1A9 UGT1A8

2.08e-06421220147615
Pubmed

UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy.

UGT1A9 UGT1A7

2.08e-06421220628391
Pubmed

Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.

UGT1A9 UGT1A7

3.47e-06521217072959
Pubmed

KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.

ZBTB33 KAT5

3.47e-06521225288747
Pubmed

Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers.

UGT1A9 UGT1A7

3.47e-06521218597651
Pubmed

The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C.

UGT1A10 UGT1A7

3.47e-06521218556656
Pubmed

An atlas of genetic influences on human blood metabolites.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.80e-0619021424816252
Pubmed

Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.

UGT1A9 UGT1A7

5.20e-06621219204906
Pubmed

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.24e-0620321416916647
Pubmed

Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.

UGT1A9 UGT1A8

9.70e-06821212695355
Pubmed

Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk.

UGT1A8 UGT1A7

9.70e-06821215319294
Pubmed

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

UGT1A9 UGT1A8

1.25e-0592121339448
Pubmed

Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.

UGT1A9 UGT1A7

2.28e-051221219349540
Pubmed

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

UGT1A10 UGT1A8

4.15e-051621220972438
Pubmed

ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.

ISL2 ADCY3

9.51e-052421224797473
Pubmed

Genome-wide association study identifies multiple loci associated with bladder cancer risk.

UGT1A10 UGT1A8

1.12e-042621224163127
InteractionUGT1A9 interactions

UGT1A9 UGT1A10 UGT1A7

2.38e-0713203int:UGT1A9
InteractionUGT1A7 interactions

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.69e-0757204int:UGT1A7
InteractionUGT1A8 interactions

UGT1A8 UGT1A7

2.81e-063202int:UGT1A8
InteractionUGT1A10 interactions

UGT1A9 UGT1A10 UGT1A7

4.47e-0633203int:UGT1A10
InteractionZNF492 interactions

ZNF675 ZNF492

7.25e-0513202int:ZNF492
InteractionZNF675 interactions

ZNF675 ZNF492

8.45e-0514202int:ZNF675
Cytoband2q37

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.01e-09312142q37
CytobandEnsembl 112 genes in cytogenetic band chr2q37

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.20e-06226214chr2q37
Cytoband19p12

ZNF675 ZNF492

7.79e-049021219p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF675 ZNF492

1.42e-03122212chr19p12
GeneFamilyUDP glucuronosyltransferases

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.07e-0832194363
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF675 HIVEP3 ZNF492 ZBTB33

5.94e-0371819428
CoexpressionWAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_36HR

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.34e-06154214MM1313
CoexpressionNFE2L2.V2

UGT1A9 UGT1A10 UGT1A8 UGT1A7 EFCAB14

2.88e-05469215M2870
Drugnaringenin chalcone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.16e-125204ctd:C027329
Druganthrarobin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.16e-125204ctd:C032186
Drugalloin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.49e-126204ctd:C006457
Drug1,2,5,8-tetrahydroxy anthraquinone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.49e-126204ctd:C543211
Drug2',5'-dihydroxychalcone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.49e-126204ctd:C107497
Drug2',4'-dihydroxychalcone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.51e-117204ctd:C059354
Drug1,4-dihydroxyanthraquinone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.02e-118204ctd:C034890
DrugAC1MRQNQ

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.44e-119204CID003522271
DrugDHPASiU

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.44e-119204CID000197602
DrugChebi:32663

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.44e-119204CID005460873
Drug3-iodophenol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.44e-119204CID000012272
DrugAC1L4J7U

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.44e-119204CID000186631
Drugindole-2-carboxylic acid

UGT1A9 UGT1A10 UGT1A8 UGT1A7 GRIN3B

6.04e-1132205CID000072899
Drug2,6-dihydroxyanthraquinone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.06e-1110204ctd:C034889
Drug4-nitrophenyl)imidazole

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.42e-1011204CID000123155
DrugAC1O5XMV

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.42e-1011204CID006442661
Druglevo-dromoran tartrate

UGT1A9 ADCY3 UGT1A10 UGT1A8 UGT1A7 GRIN3B

2.01e-1098206CID000003918
DrugN-OH-DABZ

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.13e-1012204CID000051366
Drug1-O-beta-D-glucopyranosyl-D-mannitol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.13e-1012204CID000088735
Drug7,7,7-triphenylheptanoic acid

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.13e-1012204CID000276709
Drugnonanoyl-N-methylglucamide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.13e-1012204CID000160090
Drug4-hydroxyestrone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.13e-1012204ctd:C026418
Drug2,4,6-TCB

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.13e-1012204CID000037247
Drug2-hydroxyestrone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.08e-1013204ctd:C024980
Drugcotinine-N-glucuronide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.08e-1013204CID000000411
Drugtritanol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.08e-1013204CID000006457
Drug5-azido-UDP-glucuronic acid

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.08e-1013204CID003081279
Drugalizarin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.08e-1013204ctd:C010078
Drugpropranolol glucuronide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.31e-1014204CID000119515
DrugPCB-61

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.31e-1014204CID000036401
Drugsulforaphane nitrile

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.87e-1015204CID000543743
Drug2,2',3,5,5'-pentachlorobiphenyl

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.87e-1015204CID000040469
Drugcoumarin-3-carboxylic acid

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.87e-1015204CID000010752
Drugafloqualone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.87e-1015204CID000002040
Drugbergamottin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.87e-1015204ctd:C068337
Drugnaphthyl sulphate

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.87e-1015204CID000114775
Drugquercetin-3,4'-diglucoside

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.82e-1016204CID005320835
Drug1'-hydroxyestragole

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.82e-1016204CID000040003
Drugbilirubin-phosphate

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.82e-1016204CID005497144
DrugDEPC

UGT1A9 AMPD1 UGT1A10 UGT1A8 UGT1A7

8.50e-1053205CID000015357
DrugEquol

UGT1A9 UGT1A10 UGT1A8 UGT1A7 KAT5

9.37e-1054205ctd:D060754
Drug3 beta,5 alpha,25R)- 3-hydroxyspirostan-12-one

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.02e-0917204CID000003573
Drug6-hydroxychrysene

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.02e-0917204CID000037766
DrugSureCN12722713

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.31e-0918204CID005488034
Drug2,3,7-trichlorodibenzo-p-dioxin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.31e-0918204CID000036614
DrugApApG

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.31e-0918204CID003081975
DrugC1 11-32

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.31e-0918204CID000443077
DrugC11131

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.31e-0918204CID000443076
Drugethyl-beta-D-6-glucosiduronic acid

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.31e-0918204CID000152226
DrugBr 2

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.31e-0918204CID003060900
Drugalmokalant

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.66e-0919204CID003033962
Drug9-OH-risperidone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.66e-0919204CID000475100
Drug5alpha-spirostan-3beta-ol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.66e-0919204CID000091433
Drugtectochrysin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0920204CID005281954
DrugAC1L1OBF

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0920204CID000032736
Drugentacapone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0920204ctd:C071192
Drug4'-hydroxydiclofenac

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0920204CID000116545
Drug2-vanillin

UGT1A10 UGT1A8 UGT1A7

2.32e-094203ctd:C060843
Drugdiphenylacetic acid

UGT1A10 UGT1A8 UGT1A7

2.32e-094203ctd:C037760
Drughydratropic acid

UGT1A10 UGT1A8 UGT1A7

2.32e-094203ctd:C013025
Drugestriol-16-glucuronide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.57e-0921204CID000122281
Drugdulcin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.57e-0921204CID000009013
DrugBenzamidoxime hydrochloride

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.57e-0921204CID000069186
Drugplumbagin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.13e-0922204ctd:C014758
DrugN-methylpiperazine

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.13e-0922204CID000053167
Drugamonafide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.13e-0922204CID000050515
Drugamidoxime

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.79e-0923204CID000465967
Drugestradiol-3-glucuronide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.79e-0923204CID000066651
Drugphenanthridine

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.79e-0923204CID000009189
DrugAS-3201

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.55e-0924204CID000153948
Drug7-hydroxycoumarin

UGT1A9 UGT1A10 UGT1A8 UGT1A7 KAT5

5.05e-0975205CID005281426
DrugN-acetylbenzidine

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.41e-0925204CID000018787
Drug5,6-benzoquinoline

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.41e-0925204CID000006796
Drug5-MOP

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.41e-0925204CID000002355
DrugN-phenylmaleimide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.41e-0925204CID000013662
DrugHymecromone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.41e-0925204ctd:D006923
DrugAzMC

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.41e-0925204CID000064986
Drugisovaleric acid

UGT1A10 UGT1A8 UGT1A7

5.79e-095203ctd:C008216
Drugbiphenylylacetic acid

UGT1A10 UGT1A8 UGT1A7

5.79e-095203ctd:C012776
DrugThymol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.39e-0926204ctd:D013943
Druglicochalcone A

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.50e-0927204ctd:C070840
DrugScopoletin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.50e-0927204ctd:D012603
DrugDiMeIQx

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.50e-0927204CID000104739
Drugdiflunisal

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.50e-0927204CID000003059
DrugN-hydroxy-4-aminobiphenyl

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.74e-0928204CID000081261
Drugerucin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.74e-0928204CID000078160
DrugH-Ni

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.74e-0928204CID000445665
DrugCARMINE

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.74e-0928204CID000014749
DrugAC1L1JAL

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.01e-0829204CID000004954
Drugtrans-3'-hydroxycotinine

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.01e-0829204CID000000414
Drug7-hydroxy-4-trifluoromethylcoumarin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.01e-0829204CID005375667
Drug7-hydroxycoumarin glucuronide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.01e-0829204CID000125641
Drugiberin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.01e-0829204CID000010455
Drug2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.01e-0829204ctd:C060533
Drug3-phenylpropionic acid

UGT1A10 UGT1A8 UGT1A7

1.16e-086203ctd:C035253
DrugIndoprofen

UGT1A10 UGT1A8 UGT1A7

1.16e-086203ctd:D007216
Drugparicalcitol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.17e-0830204CID005281104
DrugAC1L9E0Q

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.17e-0830204CID000443095
Drugdihydroartemisinin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.17e-0830204CID000107770
Drugtolcapone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.17e-0830204CID004659569
DiseaseN-acetyl-4-chlorophenylalanine measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.67e-135204EFO_0801060
Diseasenuclear receptor subfamily 1 group D member 2 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.67e-135204EFO_0801853
Disease5-hydroxyindole sulfate measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.67e-135204EFO_0800085
DiseaseX-21339 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.36e-127204EFO_0800808
DiseaseX-11793--oxidized bilirubin measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0021260
DiseaseSuccinimide measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0022118
DiseaseX-24849 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0800909
Diseasecholelithiasis, bilirubin measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0004570, EFO_0004799
DiseaseX-11530 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0021249
DiseaseX-11522 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0800696
DiseaseX-10458 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0800692
Diseaseserum N-desmethylclozapine measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0600043
Diseaseplasma clozapine measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0600038
Diseasemembrane-associated progesterone receptor component 1 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0802740
DiseaseX-16946 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0800766
Diseasesulfate of piperine metabolite C16H19NO3 (2) measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.07e-118204EFO_0801034
DiseaseX-11442 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.93e-119204EFO_0021236
DiseaseX-11441 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.93e-119204EFO_0021235
DiseaseX-11880 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.93e-119204EFO_0800698
Diseasecirculating cell free DNA measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.93e-119204EFO_0004739
Diseaseprotein-tyrosine kinase 6 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.93e-119204EFO_0020691
Diseasetestis-specific chromodomain protein Y 1 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.93e-119204EFO_0802127
Diseasesulfate of piperine metabolite C18H21NO3 (3) measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.93e-119204EFO_0801037
Diseasesulfate of piperine metabolite C18H21NO3 (1) measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.93e-119204EFO_0801036
Diseasebilirubin measurement, response to xenobiotic stimulus

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.93e-119204EFO_0004570, GO_0009410
DiseaseX-21448 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.21e-1110204EFO_0800816
DiseaseUDP-glucuronosyltransferase 1-6 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.21e-1110204EFO_0802185
Diseasebilirubin measurement, response to tenofovir

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.21e-1110204EFO_0004570, EFO_0009279
DiseaseX-23974 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.21e-1110204EFO_0800867
Diseasepregnenetriol sulfate measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.05e-1111204EFO_0800586
Diseaseplasma N-desmethylclozapine measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.05e-1111204EFO_0600039
Diseaseinsomnia, bilirubin measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.05e-1111204EFO_0004570, EFO_0004698
Diseasehistidine betaine (hercynine) measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.05e-1111204EFO_0800972
Diseasealdosterone measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.05e-1111204EFO_0010219
DiseaseX-21796 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.05e-1111204EFO_0800825
Diseasebiliverdin measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.57e-1112204EFO_0021033
Diseasep-cresol glucuronide measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.57e-1112204EFO_0800079
Diseasepregnenetriol disulfate measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.09e-1013204EFO_0800587
Diseaseretinol dehydrogenase 16 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.09e-1013204EFO_0802007
Diseaseblood 4-oxo-retinoic acid measurement

UGT1A9 UGT1A10 UGT1A8

2.66e-103203EFO_0022216
Diseaseindole-3-carboxylate measurement

UGT1A9 UGT1A10 UGT1A8

2.66e-103203EFO_0800043
DiseaseX-21441 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.63e-1017204EFO_0800814
Diseaselow density lipoprotein cholesterol measurement, body fat percentage

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.63e-1017204EFO_0004611, EFO_0007800
Diseaseangiopoietin-related protein 1 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.67e-1018204EFO_0801382
Diseasetissue factor measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.11e-1021204EFO_0010623
Diseaseneuroblastoma, cutaneous melanoma

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.11e-0928204EFO_0000389, EFO_0000621
Diseasexanthurenate measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.60e-0929204EFO_0010551
Diseaseresponse to dolutegravir

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.16e-0930204EFO_0600017
Disease3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP) measurement

UGT1A9 UGT1A10 UGT1A8

5.32e-096203EFO_0800566
Diseasevitamin D deficiency

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.99e-0937204EFO_0003762
Diseaseindoleacetate measurement

UGT1A9 UGT1A10 UGT1A8

3.19e-0810203EFO_0021015
Diseasevitamin D measurement, COVID-19

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.19e-0849204EFO_0004631, MONDO_0100096
Diseaseurate measurement, spine bone mineral density

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.36e-0858204EFO_0004531, EFO_0007701
DiseaseX-24588 measurement

UGT1A9 UGT1A10 UGT1A8

7.58e-0813203EFO_0800898
Diseasethyroxine measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.72e-0783204EFO_0005130
Diseasehormone measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.86e-0784204EFO_0004730
Diseasecholelithiasis

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.45e-0788204EFO_0004799
Diseasegallstones

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.86e-07108204EFO_0004210
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.69e-06147204DOID:9352 (biomarker_via_orthology)
Diseasebilirubin measurement

ZCCHC24 UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.49e-06442205EFO_0004570
Diseasedodecanedioate measurement

UGT1A10 UGT1A8

2.87e-0512202EFO_0021054
Diseasevitamin D measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.93e-05336204EFO_0004631
Diseasenon-high density lipoprotein cholesterol measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7 FKBP5

9.32e-05713205EFO_0005689
Diseasefree androgen index

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.05e-04374204EFO_0007005
Diseaseserum gamma-glutamyl transferase measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7 FKBP5

2.97e-04914205EFO_0004532
Diseaseurinary bladder carcinoma

UGT1A10 UGT1A8

4.63e-0447202MONDO_0004986
Diseasemetabolite measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.88e-04560204EFO_0004725
Diseaseurate measurement, bone density

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.11e-04619204EFO_0003923, EFO_0004531
Diseaseapolipoprotein B measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.19e-04663204EFO_0004615
Diseasetemporal horn of lateral ventricle volume measurement

UGT1A10 UGT1A8

1.08e-0372202EFO_0010333
Diseasetestosterone measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7 KAT5

1.35e-031275205EFO_0004908
Diseasedepressive symptom measurement, response to antidepressant

HIVEP3 ADCY3

1.61e-0388202EFO_0007006, GO_0036276
Diseaseattention deficit hyperactivity disorder

UGT1A9 UGT1A10 UGT1A8

1.68e-03354203EFO_0003888
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

HIVEP3 ADCY3 LY6K

1.82e-03364203EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946

Protein segments in the cluster

PeptideGeneStartEntry
VLFILLCCLYRLCKK

ADAM29

686

Q9UKF5
VCKGLYRALCIREKY

AMPD1

136

P23109
AKGDYLRCCKICYPL

EFCAB14

61

O75071
CYLKLREYTKAVECC

FKBP5

326

Q13451
FYLKCCKIRYCNLEG

LY6K

111

Q17RY6
RVYYICIVCKRSYVC

ZBTB33

491

Q86T24
YLCEFCLKYGRSLKC

KAT5

261

Q92993
RRDCYKYQCAKCRES

MEGF8

2416

Q7Z7M0
KCYKNGICRLECYES

DEFB134

31

Q4QY38
LRIKILGDCYYCICG

ADCY3

361

O60266
YCKRDYVRLFGIKCA

ISL2

76

Q96A47
ALRKCCYGYCIDLLE

GRIN3B

471

O60391
CCAYGYRKCLGKKGR

UGT1A10

506

Q9HAW8
VIYECNICGARYKKR

HIVEP3

641

Q5T1R4
CCAYGYRKCLGKKGR

UGT1A9

506

O60656
IYTCEKLYKCQECDR

ZNF675

221

Q8TD23
YKKCGCENLQLRKYC

ZNF492

71

Q9P255
VYKCIKRLDGCVYAI

WEE2

226

P0C1S8
CCAYGYRKCLGKKGR

UGT1A7

506

Q9HAW7
CCAYGYRKCLGKKGR

UGT1A8

506

Q9HAW9
LCEKCKVLGYYCRRV

ZCCHC24

226

Q8N2G6