Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	fatty acid elongase activity	ELOVL2 ELOVL7	1.10e-05	7	15	2	GO:0009922
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	PIEZO1 PIEZO2	8.00e-05	18	15	2	GO:0008381
GeneOntologyMolecularFunction	dioxygenase activity	ALOX5 KDM7A	2.40e-03	98	15	2	GO:0051213
GeneOntologyMolecularFunction	iron ion binding	ALOX5 KDM7A	6.72e-03	166	15	2	GO:0005506
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	KDM7A FADS1	9.07e-03	194	15	2	GO:0016705
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC25A40 SLC17A9 PIEZO1 PIEZO2	9.80e-03	1180	15	4	GO:0022857
GeneOntologyMolecularFunction	histone modifying activity	PRMT1 KDM7A	1.25e-02	229	15	2	GO:0140993
GeneOntologyMolecularFunction	transporter activity	SLC25A40 SLC17A9 PIEZO1 PIEZO2	1.33e-02	1289	15	4	GO:0005215
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	ELOVL2 ELOVL7	1.34e-02	238	15	2	GO:0016747
GeneOntologyMolecularFunction	oxidoreductase activity	ALOX5 KDM7A FADS1	1.81e-02	766	15	3	GO:0016491
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC25A40 SLC17A9	1.99e-02	293	15	2	GO:0008514
GeneOntologyMolecularFunction	sulfur compound binding	SULT1C4 PRMT1	2.38e-02	323	15	2	GO:1901681
GeneOntologyMolecularFunction	gated channel activity	PIEZO1 PIEZO2	2.54e-02	334	15	2	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	PIEZO1 PIEZO2	2.67e-02	343	15	2	GO:0005261
GeneOntologyBiologicalProcess	unsaturated fatty acid metabolic process	ALOX5 ELOVL2 FADS1 ELOVL7	1.83e-06	128	15	4	GO:0033559
GeneOntologyBiologicalProcess	fatty acid derivative biosynthetic process	ALOX5 ELOVL2 ELOVL7	6.73e-06	52	15	3	GO:1901570
GeneOntologyBiologicalProcess	unsaturated fatty acid biosynthetic process	ELOVL2 FADS1 ELOVL7	8.43e-06	56	15	3	GO:0006636
GeneOntologyBiologicalProcess	fatty acid biosynthetic process	ALOX5 ELOVL2 FADS1 ELOVL7	8.98e-06	191	15	4	GO:0006633
GeneOntologyBiologicalProcess	fatty acid elongation, unsaturated fatty acid	ELOVL2 ELOVL7	1.03e-05	7	15	2	GO:0019368
GeneOntologyBiologicalProcess	fatty acid elongation, polyunsaturated fatty acid	ELOVL2 ELOVL7	1.03e-05	7	15	2	GO:0034626
GeneOntologyBiologicalProcess	fatty acid elongation, monounsaturated fatty acid	ELOVL2 ELOVL7	1.03e-05	7	15	2	GO:0034625
GeneOntologyBiologicalProcess	fatty acid elongation, saturated fatty acid	ELOVL2 ELOVL7	1.38e-05	8	15	2	GO:0019367
GeneOntologyBiologicalProcess	alpha-linolenic acid metabolic process	ELOVL2 FADS1	2.21e-05	10	15	2	GO:0036109
GeneOntologyBiologicalProcess	fatty acid derivative metabolic process	ALOX5 ELOVL2 ELOVL7	2.66e-05	82	15	3	GO:1901568
GeneOntologyBiologicalProcess	monocarboxylic acid biosynthetic process	ALOX5 ELOVL2 FADS1 ELOVL7	3.02e-05	260	15	4	GO:0072330
GeneOntologyBiologicalProcess	very long-chain fatty acid biosynthetic process	ELOVL2 ELOVL7	3.83e-05	13	15	2	GO:0042761
GeneOntologyBiologicalProcess	fatty acid elongation	ELOVL2 ELOVL7	5.15e-05	15	15	2	GO:0030497
GeneOntologyBiologicalProcess	oxoacid metabolic process	SULT1C4 GBA2 ALOX5 ELOVL2 FADS1 ELOVL7	6.02e-05	1058	15	6	GO:0043436
GeneOntologyBiologicalProcess	organic acid metabolic process	SULT1C4 GBA2 ALOX5 ELOVL2 FADS1 ELOVL7	6.22e-05	1064	15	6	GO:0006082
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA biosynthetic process	ELOVL2 ELOVL7	8.38e-05	19	15	2	GO:0035338
GeneOntologyBiologicalProcess	long-chain fatty acid metabolic process	ALOX5 ELOVL2 FADS1	9.15e-05	124	15	3	GO:0001676
GeneOntologyBiologicalProcess	glycoside metabolic process	SULT1C4 GBA2	1.13e-04	22	15	2	GO:0016137
GeneOntologyBiologicalProcess	monocarboxylic acid metabolic process	GBA2 ALOX5 ELOVL2 FADS1 ELOVL7	1.23e-04	731	15	5	GO:0032787
GeneOntologyBiologicalProcess	linoleic acid metabolic process	ELOVL2 FADS1	1.24e-04	23	15	2	GO:0043651
GeneOntologyBiologicalProcess	carboxylic acid biosynthetic process	ALOX5 ELOVL2 FADS1 ELOVL7	1.24e-04	374	15	4	GO:0046394
GeneOntologyBiologicalProcess	organic acid biosynthetic process	ALOX5 ELOVL2 FADS1 ELOVL7	1.28e-04	377	15	4	GO:0016053
GeneOntologyBiologicalProcess	nucleoside bisphosphate metabolic process	SULT1C4 ELOVL2 ELOVL7	1.37e-04	142	15	3	GO:0033865
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate metabolic process	SULT1C4 ELOVL2 ELOVL7	1.37e-04	142	15	3	GO:0033875
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate metabolic process	SULT1C4 ELOVL2 ELOVL7	1.37e-04	142	15	3	GO:0034032
GeneOntologyBiologicalProcess	fatty-acyl-CoA biosynthetic process	ELOVL2 ELOVL7	1.71e-04	27	15	2	GO:0046949
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA metabolic process	ELOVL2 ELOVL7	1.71e-04	27	15	2	GO:0035336
GeneOntologyBiologicalProcess	long-chain fatty acid biosynthetic process	ALOX5 FADS1	1.98e-04	29	15	2	GO:0042759
GeneOntologyBiologicalProcess	sphingolipid metabolic process	GBA2 ELOVL2 ELOVL7	2.58e-04	176	15	3	GO:0006665
GeneOntologyBiologicalProcess	olefinic compound metabolic process	ALOX5 ELOVL2 FADS1	2.75e-04	180	15	3	GO:0120254
GeneOntologyBiologicalProcess	fatty acid metabolic process	ALOX5 ELOVL2 FADS1 ELOVL7	2.76e-04	461	15	4	GO:0006631
GeneOntologyBiologicalProcess	very long-chain fatty acid metabolic process	ELOVL2 ELOVL7	2.90e-04	35	15	2	GO:0000038
GeneOntologyBiologicalProcess	fatty-acyl-CoA metabolic process	ELOVL2 ELOVL7	4.18e-04	42	15	2	GO:0035337
GeneOntologyBiologicalProcess	membrane lipid metabolic process	GBA2 ELOVL2 ELOVL7	5.57e-04	229	15	3	GO:0006643
GeneOntologyBiologicalProcess	thioester biosynthetic process	ELOVL2 ELOVL7	5.69e-04	49	15	2	GO:0035384
GeneOntologyBiologicalProcess	acyl-CoA biosynthetic process	ELOVL2 ELOVL7	5.69e-04	49	15	2	GO:0071616
GeneOntologyBiologicalProcess	carboxylic acid metabolic process	GBA2 ALOX5 ELOVL2 FADS1 ELOVL7	6.20e-04	1035	15	5	GO:0019752
GeneOntologyBiologicalProcess	nucleoside bisphosphate biosynthetic process	ELOVL2 ELOVL7	8.81e-04	61	15	2	GO:0033866
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate biosynthetic process	ELOVL2 ELOVL7	8.81e-04	61	15	2	GO:0034030
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate biosynthetic process	ELOVL2 ELOVL7	8.81e-04	61	15	2	GO:0034033
GeneOntologyBiologicalProcess	icosanoid biosynthetic process	ALOX5 FADS1	1.06e-03	67	15	2	GO:0046456
GeneOntologyBiologicalProcess	arachidonate metabolic process	ALOX5 FADS1	1.09e-03	68	15	2	GO:0019369
GeneOntologyBiologicalProcess	small molecule biosynthetic process	ALOX5 ELOVL2 FADS1 ELOVL7	1.17e-03	676	15	4	GO:0044283
GeneOntologyBiologicalProcess	cellular response to mechanical stimulus	PIEZO1 PIEZO2	1.26e-03	73	15	2	GO:0071260
GeneOntologyBiologicalProcess	cellular response to external stimulus	PIEZO1 PIEZO2	1.29e-03	74	15	2	GO:0071496
GeneOntologyBiologicalProcess	detection of mechanical stimulus	PIEZO1 PIEZO2	1.33e-03	75	15	2	GO:0050982
GeneOntologyBiologicalProcess	sulfur compound metabolic process	SULT1C4 ELOVL2 ELOVL7	2.13e-03	365	15	3	GO:0006790
GeneOntologyBiologicalProcess	glycosyl compound metabolic process	SULT1C4 GBA2	2.16e-03	96	15	2	GO:1901657
GeneOntologyBiologicalProcess	lipid biosynthetic process	ALOX5 ELOVL2 FADS1 ELOVL7	2.31e-03	813	15	4	GO:0008610
GeneOntologyBiologicalProcess	thioester metabolic process	ELOVL2 ELOVL7	2.78e-03	109	15	2	GO:0035383
GeneOntologyBiologicalProcess	acyl-CoA metabolic process	ELOVL2 ELOVL7	2.78e-03	109	15	2	GO:0006637
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	ELOVL2 ELOVL7	3.19e-03	117	15	2	GO:0030148
GeneOntologyBiologicalProcess	icosanoid metabolic process	ALOX5 FADS1	4.66e-03	142	15	2	GO:0006690
GeneOntologyBiologicalProcess	amide metabolic process	GBA2 ELOVL2 ELOVL7	5.51e-03	511	15	3	GO:0043603
GeneOntologyBiologicalProcess	purine ribonucleotide metabolic process	SULT1C4 ELOVL2 ELOVL7	5.54e-03	512	15	3	GO:0009150
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	ELOVL2 ELOVL7	5.66e-03	157	15	2	GO:0046467
GeneOntologyBiologicalProcess	ribonucleotide metabolic process	SULT1C4 ELOVL2 ELOVL7	6.19e-03	533	15	3	GO:0009259
GeneOntologyBiologicalProcess	ribose phosphate metabolic process	SULT1C4 ELOVL2 ELOVL7	6.42e-03	540	15	3	GO:0019693
GeneOntologyBiologicalProcess	amide biosynthetic process	ELOVL2 ELOVL7	6.76e-03	172	15	2	GO:0043604
GeneOntologyBiologicalProcess	detection of external stimulus	PIEZO1 PIEZO2	6.84e-03	173	15	2	GO:0009581
GeneOntologyBiologicalProcess	detection of abiotic stimulus	PIEZO1 PIEZO2	6.99e-03	175	15	2	GO:0009582
GeneOntologyBiologicalProcess	erythrocyte differentiation	SLC25A40 PRMT1	7.07e-03	176	15	2	GO:0030218
GeneOntologyBiologicalProcess	sulfur compound biosynthetic process	ELOVL2 ELOVL7	7.22e-03	178	15	2	GO:0044272
GeneOntologyBiologicalProcess	organophosphate metabolic process	SULT1C4 ELOVL2 FADS1 ELOVL7	7.81e-03	1142	15	4	GO:0019637
GeneOntologyCellularComponent	endoplasmic reticulum membrane	GBA2 ELOVL2 PIEZO1 FADS1 ELOVL7	1.60e-03	1293	15	5	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	GBA2 ELOVL2 PIEZO1 FADS1 ELOVL7	1.63e-03	1299	15	5	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	GBA2 ELOVL2 PIEZO1 FADS1 ELOVL7	1.80e-03	1327	15	5	GO:0042175
MousePheno	increased prostaglandin level	ALOX5 FADS1	6.19e-05	13	13	2	MP:0009814
MousePheno	abnormal prostaglandin level	ALOX5 FADS1	2.56e-04	26	13	2	MP:0009811
Domain	PIEZO	PIEZO1 PIEZO2	6.02e-07	2	15	2	PF15917
Domain	Piezo	PIEZO1 PIEZO2	6.02e-07	2	15	2	IPR027272
Domain	Piezo_RRas-bd_dom	PIEZO1 PIEZO2	6.02e-07	2	15	2	IPR031334
Domain	Piezo_dom	PIEZO1 PIEZO2	6.02e-07	2	15	2	IPR031805
Domain	Piezo_RRas_bdg	PIEZO1 PIEZO2	6.02e-07	2	15	2	PF12166
Domain	ELO_CS	ELOVL2 ELOVL7	9.01e-06	6	15	2	IPR030457
Domain	ELO_fam	ELOVL2 ELOVL7	1.26e-05	7	15	2	IPR002076
Domain	ELO	ELOVL2 ELOVL7	1.26e-05	7	15	2	PF01151
Domain	ELO	ELOVL2 ELOVL7	1.26e-05	7	15	2	PS01188
Pathway	WP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS	ELOVL2 FADS1 ELOVL7	7.75e-08	12	11	3	MM17077
Pathway	WP_SEBALEIC_ACID_FORMATION_AND_METABOLISM	ALOX5 FADS1	5.53e-06	5	11	2	M48057
Pathway	REACTOME_FATTY_ACID_METABOLISM	ALOX5 ELOVL2 FADS1 ELOVL7	6.31e-06	170	11	4	MM15573
Pathway	REACTOME_FATTY_ACID_METABOLISM	ALOX5 ELOVL2 FADS1 ELOVL7	7.24e-06	176	11	4	M27854
Pathway	WP_LINOLEIC_ACID_METABOLISM_AFFECTED_BY_SARSCOV2	ELOVL2 FADS1	8.29e-06	6	11	2	M42575
Pathway	WP_METABOLISM_OF_ALPHALINOLENIC_ACID	ALOX5 FADS1	8.29e-06	6	11	2	M39844
Pathway	WP_OMEGA6FATTY_ACIDS_IN_SENESCENCE	ALOX5 ELOVL2 FADS1	1.01e-05	57	11	3	M48332
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	ELOVL2 FADS1	1.55e-05	8	11	2	MM14822
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	ELOVL2 FADS1	1.55e-05	8	11	2	M27115
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	ELOVL2 FADS1	4.30e-05	13	11	2	MM14821
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	ELOVL2 FADS1	4.30e-05	13	11	2	M27114
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ELOVL2 FADS1	5.01e-05	14	11	2	MM15840
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ELOVL2 FADS1	5.01e-05	14	11	2	M39780
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	ELOVL2 FADS1	5.78e-05	15	11	2	M39789
Pathway	REACTOME_METABOLISM_OF_LIPIDS	GBA2 ALOX5 ELOVL2 FADS1 ELOVL7	6.00e-05	620	11	5	MM15193
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	ELOVL2 FADS1	6.60e-05	16	11	2	MM15813
Pathway	KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS	ELOVL2 FADS1	1.27e-04	22	11	2	M11673
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ELOVL2 ELOVL7	1.27e-04	22	11	2	MM15451
Pathway	WP_SELENIUM_MICRONUTRIENT_NETWORK	ALOX5 FADS1	1.39e-04	23	11	2	MM15979
Pathway	WP_OXYLIPINS_PATHWAYS	ALOX5 FADS1	1.51e-04	24	11	2	MM17249
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ELOVL2 ELOVL7	1.51e-04	24	11	2	M1016
Pathway	REACTOME_METABOLISM_OF_LIPIDS	GBA2 ALOX5 ELOVL2 FADS1 ELOVL7	1.55e-04	757	11	5	M27451
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ELOVL2 ELOVL7	2.71e-04	32	11	2	MM15446
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ELOVL2 ELOVL7	3.63e-04	37	11	2	M729
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	ELOVL2 FADS1	5.87e-04	47	11	2	M39853
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	ELOVL2 FADS1	7.19e-04	52	11	2	MM15920
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	PRMT1 KDM7A	7.83e-03	175	11	2	MM14941
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	PRMT1 KDM7A	1.82e-02	272	11	2	M29619
Pubmed	Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.	PIEZO1 PIEZO2	1.74e-07	2	15	2	27743844
Pubmed	Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?	PIEZO1 PIEZO2	1.74e-07	2	15	2	30324494
Pubmed	Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles.	PIEZO1 PIEZO2	1.74e-07	2	15	2	38928429
Pubmed	Mechanisms of mechanotransduction and physiological roles of PIEZO channels.	PIEZO1 PIEZO2	1.74e-07	2	15	2	39251883
Pubmed	A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels.	PIEZO1 PIEZO2	1.74e-07	2	15	2	30628892
Pubmed	Piezo1 ion channel pore properties are dictated by C-terminal region.	PIEZO1 PIEZO2	1.74e-07	2	15	2	26008989
Pubmed	Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort).	ELOVL2 FADS1	1.74e-07	2	15	2	26633493
Pubmed	Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.	PIEZO1 PIEZO2	1.74e-07	2	15	2	37975162
Pubmed	Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.	PIEZO1 PIEZO2	1.74e-07	2	15	2	20813920
Pubmed	Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.	PIEZO1 PIEZO2	1.74e-07	2	15	2	28636944
Pubmed	[Feeling the pressure? Identification of two proteins activated by mechanical forces].	PIEZO1 PIEZO2	1.74e-07	2	15	2	21299953
Pubmed	A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.	PIEZO1 PIEZO2	1.74e-07	2	15	2	32142647
Pubmed	FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women.	ELOVL2 FADS1	1.74e-07	2	15	2	32502762
Pubmed	Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.	PIEZO1 PIEZO2	1.74e-07	2	15	2	34464353
Pubmed	Mechanosensitive channels: in touch with Piezo.	PIEZO1 PIEZO2	1.74e-07	2	15	2	21056836
Pubmed	Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration.	PIEZO1 PIEZO2	1.74e-07	2	15	2	30745454
Pubmed	The role of PIEZO ion channels in the musculoskeletal system.	PIEZO1 PIEZO2	1.74e-07	2	15	2	36717101
Pubmed	Piezo channels: from structure to function.	PIEZO1 PIEZO2	1.74e-07	2	15	2	25037583
Pubmed	Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.	PIEZO1 PIEZO2	1.74e-07	2	15	2	38395992
Pubmed	Genetic variants in FADS1 and ELOVL2 increase level of arachidonic acid and the risk of Alzheimer's disease in the Tunisian population.	ELOVL2 FADS1	1.74e-07	2	15	2	32682282
Pubmed	Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.	PIEZO1 PIEZO2	1.74e-07	2	15	2	37820892
Pubmed	Astrocytes in the optic nerve head express putative mechanosensitive channels.	PIEZO1 PIEZO2	1.74e-07	2	15	2	26236150
Pubmed	Piezo1, a mechanically activated ion channel, is required for vascular development in mice.	PIEZO1 PIEZO2	5.21e-07	3	15	2	24958852
Pubmed	A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population.	ELOVL2 FADS1	5.21e-07	3	15	2	21917437
Pubmed	Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics.	PIEZO1 PIEZO2	5.21e-07	3	15	2	38124148
Pubmed	A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population.	ELOVL2 FADS1	5.21e-07	3	15	2	23555103
Pubmed	[A case-control study between gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and paranoid schizophrenia of Han ethnicity in Jilin Province].	ELOVL2 FADS1	5.21e-07	3	15	2	21560298
Pubmed	Labeling PIEZO2 activity in the peripheral nervous system.	PIEZO1 PIEZO2	5.21e-07	3	15	2	37321223
Pubmed	Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.	PIEZO1 PIEZO2	5.21e-07	3	15	2	29521261
Pubmed	Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.	PIEZO1 PIEZO2	5.21e-07	3	15	2	30726728
Pubmed	Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.	PIEZO1 PIEZO2	5.21e-07	3	15	2	35650194
Pubmed	Association Between Genetic Variants in FADS1-FADS2 and ELOVL2 and Obesity, Lipid Traits, and Fatty Acids in Tunisian Population.	ELOVL2 FADS1	5.21e-07	3	15	2	32584610
Pubmed	PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex.	PIEZO1 PIEZO2	5.21e-07	3	15	2	30361375
Pubmed	Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.	PIEZO1 PIEZO2	1.04e-06	4	15	2	36574677
Pubmed	Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.	PIEZO1 PIEZO2	1.04e-06	4	15	2	27893727
Pubmed	Increased Δ5- and Δ6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis.	ALOX5 FADS1	1.04e-06	4	15	2	21605700
Pubmed	Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.	PIEZO1 PIEZO2	1.04e-06	4	15	2	36563677
Pubmed	Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.	ELOVL2 FADS1	1.04e-06	4	15	2	19148276
Pubmed	Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa.	SLC17A9 PIEZO1	1.73e-06	5	15	2	28060940
Pubmed	Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.	PIEZO1 PIEZO2	1.73e-06	5	15	2	36323321
Pubmed	Piezo1 and Piezo2 foster mechanical gating of K2P channels.	PIEZO1 PIEZO2	1.73e-06	5	15	2	34852225
Pubmed	Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.	PIEZO1 PIEZO2	3.64e-06	7	15	2	38733989
Pubmed	The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.	PIEZO1 PIEZO2	4.85e-06	8	15	2	38228630
Pubmed	Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.	PIEZO1 PIEZO2	4.85e-06	8	15	2	27161260
Pubmed	TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.	PIEZO1 PIEZO2	4.85e-06	8	15	2	34112781
Pubmed	Piezo1 and Piezo2 collectively regulate jawbone development.	PIEZO1 PIEZO2	4.85e-06	8	15	2	38619396
Pubmed	A genome-wide perspective of genetic variation in human metabolism.	ELOVL2 FADS1	6.24e-06	9	15	2	20037589
Pubmed	ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.	ELOVL2 ELOVL7	7.80e-06	10	15	2	20937905
Pubmed	Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.	ELOVL2 ELOVL7	9.53e-06	11	15	2	23689133
Pubmed	A vagal reflex evoked by airway closure.	PIEZO1 PIEZO2	2.08e-05	16	15	2	38448588
Pubmed	Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin.	PIEZO1 PIEZO2	4.77e-05	24	15	2	32186512
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	ELOVL2 ELOVL7	6.06e-05	27	15	2	25269881
Pubmed	Biosynthesis of triacylglycerols.	ELOVL2 ELOVL7	6.52e-05	28	15	2	8944226
Pubmed	Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.	ELOVL2 FADS1	7.00e-05	29	15	2	38485951
Pubmed	Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.	ELOVL2 FADS1	7.00e-05	29	15	2	21829377
Pubmed	Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes.	SLC25A40 PRMT1	7.50e-05	30	15	2	34745083
Pubmed	Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.	FADS1 ELOVL7	1.34e-04	40	15	2	27760309
Pubmed	Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.	ELOVL2 FADS1	1.94e-04	48	15	2	22359512
Pubmed	Calcium signaling induces partial EMT and renal fibrosis in a Wnt4mCherry knock-in mouse model.	PIEZO1 PIEZO2	2.36e-04	53	15	2	38653356
Pubmed	Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.	ELOVL2 FADS1	2.45e-04	54	15	2	24823311
Pubmed	Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad.	PRMT1 PIEZO1	2.73e-04	57	15	2	14595844
Pubmed	Human metabolic individuality in biomedical and pharmaceutical research.	ELOVL2 FADS1	2.73e-04	57	15	2	21886157
Pubmed	Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.	ELOVL2 FADS1	3.13e-04	61	15	2	22916037
GeneFamily	Solute carriers	SLC25A40 SLC17A9	1.22e-02	395	8	2	752
CoexpressionAtlas	dev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#2_top-relative-expression-ranked_1000	PIEZO1 PIEZO2 FADS1	5.12e-05	105	15	3	gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k2_1000
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A40 SLC17A9 ALOX5 FADS1	2.85e-07	174	15	4	7f8f6a15a823809effd37c1a5b09ef19b6d67755
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-Alox5+_Lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A40 SLC17A9 ALOX5 FADS1	2.85e-07	174	15	4	a8bd1fa08bf061a627529a38e5a23a68b6d80697
ToppCell	droplet-Marrow-BM-1m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC17A9 ALOX5 ELOVL7	2.37e-05	171	15	3	8a0c08f0aa3a80cd6346c81deb242e430ebd897b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC17A9 PRMT1 PIEZO1	3.15e-05	188	15	3	34873972dff9284dfcd26bb698c9d1df007f1cbb
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|World / Lineage and Cell class	PIEZO2 FADS1 ELOVL7	3.25e-05	190	15	3	1d19b2bd55789bf13e1386332f46c605973d6f8e
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLC25A40 ALOX5 FADS1	3.51e-05	195	15	3	c96755d2eb98112b703b5dbee9c88730ace7dcbf
ToppCell	CV-Mild-2\|CV / Virus stimulation, Condition and Cluster	SLC17A9 PRMT1 FADS1	3.62e-05	197	15	3	dc1cfba2ee66c62b53accefbfce3025cd760524a
Drug	5,8,11-eicosatrienoic acid	ALOX5 ELOVL2	9.29e-05	22	15	2	CID000004028
Drug	AC1L1FF5	ALOX5 ELOVL2 FADS1	1.38e-04	157	15	3	CID000003209
Drug	Etodolac [41340-25-4]; Down 200; 14uM; PC3; HT_HG-U133A	ELOVL2 PIEZO1 FADS1	2.77e-04	199	15	3	7246_DN
Drug	Fatty Acids, Unsaturated	ELOVL2 FADS1	2.81e-04	38	15	2	ctd:D005231
Drug	Trimethylsilyl	GBA2 ALOX5	3.11e-04	40	15	2	CID000123362
Drug	Fatty Acids, Essential	ELOVL2 FADS1	6.78e-04	59	15	2	ctd:D005228
Drug	3-hydroxyanthranilic acid	PRMT1 ALOX5	7.25e-04	61	15	2	CID000000086
Drug	obeticholic acid	PRMT1 ELOVL2 ELOVL7	7.74e-04	283	15	3	ctd:C464660
Drug	NSC734102	SULT1C4 HCRTR2	1.06e-03	74	15	2	CID000444075
Drug	6,9,12-octadecatrienoic acid	ALOX5 FADS1	1.18e-03	78	15	2	CID000003453
Disease	fatty acid measurement, docosapentaenoic acid measurement	ELOVL2 FADS1	2.41e-06	5	15	2	EFO_0005110, EFO_0006809
Disease	1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6) measurement	ELOVL2 FADS1	5.06e-06	7	15	2	EFO_0800391
Disease	1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6) measurement	ELOVL2 FADS1	6.74e-06	8	15	2	EFO_0800392
Disease	1-stearoyl-2-docosapentaenoyl-GPC (18:0/22:5n3) measurement	ELOVL2 FADS1	6.74e-06	8	15	2	EFO_0800455
Disease	lysophosphatidylcholine 22:5 measurement	ELOVL2 FADS1	2.19e-05	14	15	2	EFO_0021462
Disease	diacylglycerol 38:5 measurement	ELOVL2 FADS1	4.10e-05	19	15	2	EFO_0020067
Disease	docosapentaenoic acid measurement	ELOVL2 FADS1	8.40e-05	27	15	2	EFO_0006809
Disease	phosphatidylethanolamine measurement	ELOVL2 FADS1 ELOVL7	8.56e-05	173	15	3	EFO_0010228
Disease	eicosapentaenoic acid measurement	ELOVL2 FADS1	1.11e-04	31	15	2	EFO_0007760
Disease	cholesteryl ester 22:6 measurement	ELOVL2 FADS1	1.19e-04	32	15	2	EFO_0010350
Disease	ecosanoids measurement	ELOVL2 FADS1	3.53e-04	55	15	2	EFO_0020044
Disease	fatty acid measurement, linoleic acid measurement	ELOVL2 FADS1	5.39e-04	68	15	2	EFO_0005110, EFO_0006807
Disease	phosphatidylinositol measurement	ELOVL2 FADS1	1.05e-03	95	15	2	EFO_0010230
Disease	docosahexaenoic acid measurement	ELOVL2 FADS1	1.86e-03	127	15	2	EFO_0007761

Protein segments in the cluster

Peptide	Gene	Start	Entry
RQYKDYKIHWWENVY	PRMT1	206	Q99873
WYHVLWGEKIFYLIK	KDM7A	291	Q6ZMT4
KWLWYENRIYVLGYV	NEMP2	231	A6NFY4
RYLWREYLHPKEYEW	HCRTR2	41	O43614
EKRHWKRYIYLWINY	CRNKL1	526	Q9BZJ0
YLQWWYRKTHVEKKT	GBA2	121	Q9HCG7
HKYLWWKKYLTQAQL	ELOVL2	196	Q9NXB9
AYQKYLWWKKYLTSL	ELOVL7	196	A1L3X0
WYIFYFVIQRKKWVD	FADS1	281	O60427
AMYWYNYEILKKWLC	SLC25A40	211	Q8TBP6
EKRKYWLNDDWYLKY	ALOX5	71	P09917
LWVWYVYRYLLSEKD	SLC17A9	196	Q9BYT1
WWEAKDKHRILYLFY	SULT1C4	186	O75897
LYQVHYEWWRKILKY	PIEZO2	721	Q9H5I5
QVYYSLWRKLLKAFW	PIEZO1	616	Q92508