Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	retinoic acid binding	UGT1A4 UGT1A3 UGT1A5	4.92e-05	28	51	3	GO:0001972
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT1A4 UGT1A3 UGT1A5	9.70e-05	35	51	3	GO:0015020
GeneOntologyMolecularFunction	monocarboxylic acid binding	UGT1A4 UGT1A3 UGT1A5 NR1H4	1.60e-04	107	51	4	GO:0033293
GeneOntologyMolecularFunction	retinoid binding	UGT1A4 UGT1A3 UGT1A5	2.50e-04	48	51	3	GO:0005501
GeneOntologyMolecularFunction	isoprenoid binding	UGT1A4 UGT1A3 UGT1A5	2.66e-04	49	51	3	GO:0019840
GeneOntologyMolecularFunction	carboxylic acid binding	UGT1A4 UGT1A3 GAD2 UGT1A5 NR1H4	3.53e-04	239	51	5	GO:0031406
GeneOntologyMolecularFunction	organic acid binding	UGT1A4 UGT1A3 GAD2 UGT1A5 NR1H4	4.67e-04	254	51	5	GO:0043177
GeneOntologyMolecularFunction	histone kinase activity	BUB1 PRKDC	2.32e-03	28	51	2	GO:0035173
GeneOntologyBiologicalProcess	intracellular receptor signaling pathway	WBP2 UBQLN1 WASHC4 LBH POU4F2 PRKDC NR1H4 EPG5	7.63e-06	416	51	8	GO:0030522
GeneOntologyBiologicalProcess	endolysosomal toll-like receptor signaling pathway	UBQLN1 WASHC4 NR1H4 EPG5	1.11e-05	56	51	4	GO:0140894
GeneOntologyBiologicalProcess	cellular glucuronidation	UGT1A4 UGT1A3 UGT1A5	1.84e-05	21	51	3	GO:0052695
GeneOntologyBiologicalProcess	glucuronate metabolic process	UGT1A4 UGT1A3 UGT1A5	3.56e-05	26	51	3	GO:0019585
GeneOntologyBiologicalProcess	uronic acid metabolic process	UGT1A4 UGT1A3 UGT1A5	3.56e-05	26	51	3	GO:0006063
GeneOntologyBiologicalProcess	regulation of organelle organization	S100A10 MYH9 UBQLN2 WASHC4 BUB1 SMARCB1 TOGARAM1 AKAP13 IQCJ-SCHIP1 ZW10 ARMH3 CLEC16A	8.10e-05	1342	51	12	GO:0033043
GeneOntologyBiologicalProcess	pattern recognition receptor signaling pathway	UBQLN1 WASHC4 APPL2 PRKDC NR1H4 EPG5	8.37e-05	294	51	6	GO:0002221
GeneOntologyBiologicalProcess	cytoplasmic pattern recognition receptor signaling pathway	UBQLN1 WASHC4 PRKDC NR1H4 EPG5	9.97e-05	188	51	5	GO:0002753
GeneOntologyBiologicalProcess	innate immune response-activating signaling pathway	UBQLN1 WASHC4 APPL2 PRKDC NR1H4 EPG5	1.16e-04	312	51	6	GO:0002758
GeneOntologyBiologicalProcess	activation of innate immune response	UBQLN1 WASHC4 APPL2 PRKDC NR1H4 EPG5	1.65e-04	333	51	6	GO:0002218
GeneOntologyBiologicalProcess	regulation of plasma membrane repair	S100A10 MYH9	1.66e-04	8	51	2	GO:1905684
GeneOntologyBiologicalProcess	vitamin D3 metabolic process	UGT1A4 UGT1A3	2.13e-04	9	51	2	GO:0070640
GeneOntologyBiologicalProcess	hormone-mediated signaling pathway	WBP2 APPL2 LBH AKAP13 POU4F2	3.35e-04	244	51	5	GO:0009755
GeneOntologyBiologicalProcess	estrogen receptor signaling pathway	WBP2 LBH POU4F2	3.79e-04	57	51	3	GO:0030520
MousePheno	increased chromosomal stability	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C	6.93e-10	6	38	4	MP:0010095
MousePheno	abnormal chromosome stability	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C BUB1	1.40e-05	115	38	5	MP:0010094
MousePheno	abnormal intracellular organelle physiology	ZSCAN5B WASHC4 ZSCAN5DP ZSCAN5A ZSCAN5C BUB1 ABCG2 PRKDC	7.44e-05	532	38	8	MP:0014241
Domain	ARM-type_fold	UBQLN2 UBQLN1 MROH2B INTS1 TOGARAM1 PRKDC ARMH3 STAG2	3.00e-06	339	50	8	IPR016024
Domain	Ubiquilin-1/2	UBQLN2 UBQLN1	7.02e-06	2	50	2	IPR028430
Domain	SCAN_BOX	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C	1.73e-05	58	50	4	PS50804
Domain	SCAN	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C	1.73e-05	58	50	4	PF02023
Domain	SCAN_dom	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C	1.73e-05	58	50	4	IPR003309
Domain	Retrov_capsid_C	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C	1.86e-05	59	50	4	IPR008916
Domain	UDPGT	UGT1A4 UGT1A3 UGT1A5	2.32e-05	21	50	3	PS00375
Domain	UDPGT	UGT1A4 UGT1A3 UGT1A5	2.32e-05	21	50	3	PF00201
Domain	UDP_glucos_trans	UGT1A4 UGT1A3 UGT1A5	2.32e-05	21	50	3	IPR002213
Domain	Ubiquilin	UBQLN2 UBQLN1	1.05e-04	6	50	2	IPR015496
Domain	STI1_HS-bd	UBQLN2 UBQLN1	3.12e-04	10	50	2	IPR006636
Domain	STI1	UBQLN2 UBQLN1	3.12e-04	10	50	2	SM00727
Domain	SCAN	ZSCAN5B ZSCAN5A ZSCAN5C	4.53e-04	56	50	3	SM00431
Domain	HEAT_REPEAT	MROH2B TOGARAM1 PRKDC	8.71e-04	70	50	3	PS50077
Domain	6-PGluconate_DH_C-like	UBQLN2 UBQLN1	1.17e-03	19	50	2	IPR008927
Domain	C2H2_Znf_fam	ZSCAN5B ZSCAN5A	1.87e-03	24	50	2	IPR027775
Domain	UBA	UBQLN2 UBQLN1	2.91e-03	30	50	2	SM00165
Domain	UBA	UBQLN2 UBQLN1	4.18e-03	36	50	2	PF00627
Domain	UBIQUITIN_1	UBQLN2 UBQLN1	4.41e-03	37	50	2	PS00299
Domain	ARM-like	MROH2B TOGARAM1 PRKDC STAG2	5.84e-03	270	50	4	IPR011989
Domain	UBQ	UBQLN2 UBQLN1	5.91e-03	43	50	2	SM00213
Domain	UBA	UBQLN2 UBQLN1	6.18e-03	44	50	2	IPR015940
Domain	UBA	UBQLN2 UBQLN1	7.03e-03	47	50	2	PS50030
Domain	ubiquitin	UBQLN2 UBQLN1	7.03e-03	47	50	2	PF00240
Domain	UBIQUITIN_2	UBQLN2 UBQLN1	9.20e-03	54	50	2	PS50053
Domain	HEAT	TOGARAM1 PRKDC	1.06e-02	58	50	2	IPR000357
Domain	Ubiquitin_dom	UBQLN2 UBQLN1	1.06e-02	58	50	2	IPR000626
Domain	UBA-like	UBQLN2 UBQLN1	1.27e-02	64	50	2	IPR009060
Pathway	REACTOME_ATORVASTATIN_ADME	UGT1A4 UGT1A3 UGT1A5	6.25e-06	15	35	3	MM15697
Pathway	REACTOME_HEME_DEGRADATION	UGT1A4 UGT1A3 UGT1A5	1.55e-05	20	35	3	MM14721
Pathway	REACTOME_PREDNISONE_ADME	UGT1A4 UGT1A3 UGT1A5	2.40e-05	23	35	3	MM16639
Pathway	REACTOME_GLUCURONIDATION	UGT1A4 UGT1A3 UGT1A5	2.74e-05	24	35	3	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT1A4 UGT1A3 UGT1A5	3.11e-05	25	35	3	M17787
Pathway	WP_GLUCURONIDATION	UGT1A4 UGT1A3 UGT1A5	3.11e-05	25	35	3	MM15820
Pathway	KEGG_ASCORBATE_AND_ALDARATE_METABOLISM	UGT1A4 UGT1A3 UGT1A5	3.11e-05	25	35	3	M605
Pathway	WP_GLUCURONIDATION	UGT1A4 UGT1A3 UGT1A5	3.51e-05	26	35	3	M39404
Pathway	KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	UGT1A4 UGT1A3 UGT1A5	4.40e-05	28	35	3	M19580
Pathway	REACTOME_METABOLISM_OF_PORPHYRINS	UGT1A4 UGT1A3 UGT1A5	6.62e-05	32	35	3	MM14719
Pathway	KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	UGT1A4 UGT1A3 UGT1A5	1.40e-04	41	35	3	M7399
Pathway	REACTOME_DRUG_ADME	UGT1A4 UGT1A3 UGT1A5 ABCG2	1.47e-04	109	35	4	M45012
Pathway	REACTOME_ASPIRIN_ADME	UGT1A4 UGT1A3 UGT1A5	1.73e-04	44	35	3	M45014
Pathway	REACTOME_ASPIRIN_ADME	UGT1A4 UGT1A3 UGT1A5	1.85e-04	45	35	3	MM15694
Pathway	WP_ATM_SIGNALING_IN_DEVELOPMENT_AND_DISEASE	BUB1 PRKDC MAPK13	2.11e-04	47	35	3	M39518
Pathway	KEGG_DRUG_METABOLISM_OTHER_ENZYMES	UGT1A4 UGT1A3 UGT1A5	2.69e-04	51	35	3	M17726
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	UGT1A4 UGT1A3 UGT1A5	2.85e-04	52	35	3	M14171
Pathway	KEGG_STEROID_HORMONE_BIOSYNTHESIS	UGT1A4 UGT1A3 UGT1A5	3.37e-04	55	35	3	M14933
Pathway	KEGG_RETINOL_METABOLISM	UGT1A4 UGT1A3 UGT1A5	5.27e-04	64	35	3	M9488
Pathway	REACTOME_HEME_DEGRADATION	UGT1A4 ABCG2	6.16e-04	15	35	2	M27060
Pathway	KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	UGT1A4 UGT1A3 UGT1A5	6.85e-04	70	35	3	M16794
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	UGT1A4 UGT1A3 UGT1A5	7.44e-04	72	35	3	M9257
Pathway	REACTOME_MEMBRANE_TRAFFICKING	NAA35 MYH9 UBQLN2 UBQLN1 COG6 ZW10 F5	7.75e-04	630	35	7	M11480
Pathway	KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	BUB1 MAPK13 ADCY3	1.20e-03	85	35	3	M3578
Pathway	WP_ESTROGEN_METABOLISM	UGT1A3 UGT1A5	1.34e-03	22	35	2	MM15888
Pathway	WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING	ABCG2 MAPK13	1.47e-03	23	35	2	M39709
Pathway	REACTOME_VESICLE_MEDIATED_TRANSPORT	NAA35 MYH9 UBQLN2 UBQLN1 COG6 ZW10 F5	1.76e-03	725	35	7	M27507
Pathway	REACTOME_METABOLISM_OF_PORPHYRINS	UGT1A4 ABCG2	2.02e-03	27	35	2	M1088
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	UGT1A4 UGT1A3 UGT1A5 NR1H4	2.03e-03	219	35	4	MM14838
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	UGT1A4 UGT1A3 UGT1A5 NR1H4	2.07e-03	220	35	4	M10320
Pathway	REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS	UGT1A4 UGT1A3 UGT1A5	2.33e-03	107	35	3	MM14595
Pathway	WP_THERMOGENESIS	SMARCB1 MAPK13 ADCY3	2.39e-03	108	35	3	M39746
Pathway	REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS	UGT1A4 UGT1A3 UGT1A5	2.46e-03	109	35	3	M18788
Pathway	KEGG_MEDICUS_REFERENCE_DYNEIN_RECRUITMENT_TO_THE_KINETOCHORE	BUB1 ZW10	2.49e-03	30	35	2	M47889
Pubmed	Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C	4.10e-12	4	51	4	31155506
Pubmed	ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes and extra-TFIIIC (ETC) sites to modulate mitotic progression.	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C	4.10e-12	4	51	4	27732952
Pubmed	NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C	1.43e-07	32	51	4	38060382
Pubmed	A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.	UGT1A4 UGT1A3 UGT1A5	2.48e-07	9	51	3	22511988
Pubmed	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.	UGT1A4 UGT1A3 UGT1A5	2.48e-07	9	51	3	1339448
Pubmed	Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.	UGT1A4 UGT1A3 UGT1A5	3.54e-07	10	51	3	23642732
Pubmed	UDP-glucuronosyltransferases.	UGT1A4 UGT1A3 UGT1A5	3.54e-07	10	51	3	11465080
Pubmed	A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.	UGT1A4 UGT1A3 UGT1A5	3.54e-07	10	51	3	23371916
Pubmed	A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.	UGT1A4 UGT1A3 UGT1A5	3.54e-07	10	51	3	22558097
Pubmed	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	UGT1A4 UGT1A3 UGT1A5	6.47e-07	12	51	3	19419973
Pubmed	Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.	UGT1A4 UGT1A3 UGT1A5	6.47e-07	12	51	3	11434514
Pubmed	UGT1A1 is a major locus influencing bilirubin levels in African Americans.	UGT1A4 UGT1A3 UGT1A5	8.41e-07	13	51	3	22085899
Pubmed	Genome-wide analysis of hepatic lipid content in extreme obesity.	UGT1A4 UGT1A3 UGT1A5	8.41e-07	13	51	3	25246029
Pubmed	Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.	UGT1A4 UGT1A3 UGT1A5	1.07e-06	14	51	3	21646302
Pubmed	Human UDP-glucuronosyltransferases: metabolism, expression, and disease.	UGT1A4 UGT1A3 UGT1A5	1.07e-06	14	51	3	10836148
Pubmed	Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.	UGT1A4 UGT1A3 UGT1A5	1.07e-06	14	51	3	14672974
Pubmed	The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.	UGT1A4 UGT1A3 UGT1A5	1.07e-06	14	51	3	9295054
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C	1.64e-06	58	51	4	31598710
Pubmed	Genome-wide association meta-analysis for total serum bilirubin levels.	UGT1A4 UGT1A3 UGT1A5	1.64e-06	16	51	3	19414484
Pubmed	Genome-wide association of serum bilirubin levels in Korean population.	UGT1A4 UGT1A3 UGT1A5	1.99e-06	17	51	3	20639394
Pubmed	Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin.	UGT1A3 UGT1A5	2.11e-06	2	51	2	8068691
Pubmed	Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids.	UGT1A3 NR1H4	2.11e-06	2	51	2	20189675
Pubmed	Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.	UGT1A4 UGT1A3	2.11e-06	2	51	2	24641623
Pubmed	A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.	UBQLN2 UBQLN1	2.11e-06	2	51	2	29247619
Pubmed	Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis.	UBQLN2 UBQLN1	2.11e-06	2	51	2	35063704
Pubmed	N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases.	UGT1A4 UGT1A3	2.11e-06	2	51	2	14570768
Pubmed	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	UGT1A4 UGT1A3 UGT1A5 ABCG2	2.76e-06	66	51	4	19898482
Pubmed	A genome-wide assessment of variability in human serum metabolism.	UGT1A4 UGT1A3 UGT1A5	2.83e-06	19	51	3	23281178
Pubmed	Genetic determinants influencing human serum metabolome among African Americans.	UGT1A4 UGT1A3 UGT1A5	5.88e-06	24	51	3	24625756
Pubmed	Ubiquitin receptor proteins hHR23a and hPLIC2 interact.	UBQLN2 UBQLN1	6.32e-06	3	51	2	17098253
Pubmed	Isolation and characterization of a UDP-glucuronosyltransferase (UGT1A01) cloned from female rhesus monkey.	UGT1A3 UGT1A5	6.32e-06	3	51	2	12051676
Pubmed	Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.	UBQLN2 UBQLN1	6.32e-06	3	51	2	20529957
Pubmed	Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.	UGT1A4 UGT1A3	6.32e-06	3	51	2	23611809
Pubmed	A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I molecules.	UGT1A3 UGT1A5	6.32e-06	3	51	2	21383159
Pubmed	Defining the membrane proteome of NK cells.	MYH9 ATP13A1 BUB1 INTS1 AKAP13 PRKDC ZW10 F5 ADCY3 STAG2	6.41e-06	1168	51	10	19946888
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	UBQLN2 UBQLN1 WASHC4 INTS1 PRKDC ADCY3	7.62e-06	322	51	6	26514267
Pubmed	Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.	UGT1A4 UGT1A5	1.26e-05	4	51	2	18223459
Pubmed	UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding.	UBQLN2 UBQLN1	1.26e-05	4	51	2	36423739
Pubmed	E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure.	UBQLN2 UBQLN1	1.26e-05	4	51	2	36827983
Pubmed	Herp enhances ER-associated protein degradation by recruiting ubiquilins.	UBQLN2 UBQLN1	1.26e-05	4	51	2	18307982
Pubmed	Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.	UGT1A3 UGT1A5	1.26e-05	4	51	2	12644700
Pubmed	Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8.	UGT1A4 UGT1A3	1.26e-05	4	51	2	9535849
Pubmed	Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.	UGT1A4 UGT1A3	1.26e-05	4	51	2	9271343
Pubmed	PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.	UBQLN2 UBQLN1	1.26e-05	4	51	2	19148225
Pubmed	p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.	A1CF MAPK13	1.26e-05	4	51	2	34758018
Pubmed	Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins.	UBQLN2 UBQLN1	1.26e-05	4	51	2	16813565
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	S100A10 NAA35 METTL13 MYH9 UBQLN2 UBQLN1 SMARCB1 AKAP13 PRKDC KLHL8	1.59e-05	1297	51	10	33545068
Pubmed	A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes.	AKAP13 PRKDC	2.10e-05	5	51	2	29298866
Pubmed	Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations.	UGT1A3 UGT1A5	2.10e-05	5	51	2	7677729
Pubmed	Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin.	UBQLN2 UBQLN1	2.10e-05	5	51	2	15975090
Pubmed	Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.	PRKDC NR1H4	2.10e-05	5	51	2	19833092
Pubmed	Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.	UGT1A4 UGT1A3	2.10e-05	5	51	2	15057901
Pubmed	Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.	UBQLN2 UBQLN1	2.10e-05	5	51	2	10549293
Pubmed	Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.	UBQLN2 UBQLN1	2.10e-05	5	51	2	11827521
Pubmed	Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.	WBP2 MYH9 PRKDC	2.82e-05	40	51	3	30865227
Pubmed	Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.	UGT1A4 UGT1A3	3.15e-05	6	51	2	19204906
Pubmed	RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.	UBQLN2 UBQLN1	3.15e-05	6	51	2	35247097
Pubmed	Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.	UGT1A4 UGT1A5	4.41e-05	7	51	2	8467709
Pubmed	The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.	UBQLN2 UBQLN1	4.41e-05	7	51	2	10983987
Pubmed	Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.	UBQLN2 UBQLN1	4.41e-05	7	51	2	23774650
Pubmed	The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.	UBQLN2 UBQLN1	4.41e-05	7	51	2	18199683
Pubmed	Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).	UGT1A3 UGT1A5	4.41e-05	7	51	2	8464825
Pubmed	Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.	UBQLN2 UBQLN1	4.41e-05	7	51	2	27345149
Pubmed	Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis.	UBQLN2 UBQLN1	4.41e-05	7	51	2	20059542
Pubmed	Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.	UBQLN2 UBQLN1	4.41e-05	7	51	2	30664872
Pubmed	Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B.	UBQLN2 UBQLN1	4.41e-05	7	51	2	18535780
Pubmed	Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.	UGT1A4 UGT1A3	5.87e-05	8	51	2	17179145
Pubmed	Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.	UGT1A4 UGT1A3	5.87e-05	8	51	2	20610558
Pubmed	Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.	UGT1A4 UGT1A3	5.87e-05	8	51	2	12695355
Pubmed	Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.	UBQLN2 UBQLN1	5.87e-05	8	51	2	23459205
Pubmed	Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry.	UGT1A4 UGT1A3	5.87e-05	8	51	2	22579593
Pubmed	HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins.	SMARCB1 PRKDC	5.87e-05	8	51	2	15875659
Pubmed	Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.	SMARCB1 PRKDC	5.87e-05	8	51	2	16075307
Pubmed	GABAergic neuronal IL-4R mediates T cell effect on memory.	GAD2 PRKDC	5.87e-05	8	51	2	34793707
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	UBQLN2 UBQLN1 RNF139 EPG5	7.09e-05	150	51	4	32423001
Pubmed	Pou3f1 orchestrates a gene regulatory network controlling contralateral retinogeniculate projections.	GAD2 POU4F2	7.54e-05	9	51	2	37590135
Pubmed	Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway.	GAD2 ADCY3	7.54e-05	9	51	2	15611992
Pubmed	Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina.	GAD2 POU4F2	7.54e-05	9	51	2	12724837
Pubmed	Human metabolic individuality in biomedical and pharmaceutical research.	UGT1A4 UGT1A3 UGT1A5	8.22e-05	57	51	3	21886157
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	WBP2 S100A10 GAD2 UBQLN2 UBQLN1 WASHC4 APPL2 ATP13A1 PRKDC	9.36e-05	1285	51	9	35914814
Pubmed	Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.	UGT1A4 UGT1A3	1.38e-04	12	51	2	20308471
Pubmed	Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis.	UGT1A4 UGT1A3	1.38e-04	12	51	2	18161889
Pubmed	PAQR9 Modulates BAG6-mediated protein quality control of mislocalized membrane proteins.	UBQLN2 UBQLN1	1.38e-04	12	51	2	31904842
Pubmed	UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.	UBQLN2 UBQLN1	1.63e-04	13	51	2	27477512
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	BCL9L TOGARAM1 AKAP13 PRKDC F5	1.86e-04	361	51	5	26167880
Pubmed	Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development.	GAD2 POU4F2	1.90e-04	14	51	2	14625556
Pubmed	Selection system for genes encoding nuclear-targeted proteins.	NOL4 UBQLN2	1.90e-04	14	51	2	9853615
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C STAG2	1.91e-04	363	51	5	14691545
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	METTL13 MYH9 BUB1 INTS1 PRKDC STAG2	2.03e-04	582	51	6	20467437
Pubmed	Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.	MYH9 AKAP13 PRKDC	2.17e-04	79	51	3	29121065
Pubmed	Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.	WBP2 MYH9 LBH	2.25e-04	80	51	3	16094384
Pubmed	Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.	MYH9 AKAP13 PRKDC	2.42e-04	82	51	3	30274258
Pubmed	BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons.	GAD2 POU4F2	2.50e-04	16	51	2	19339595
Pubmed	Discovery and refinement of loci associated with lipid levels.	UGT1A4 UGT1A3 UGT1A5 KLHL8	2.63e-04	211	51	4	24097068
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	UBQLN1 INTS1 SMARCB1 PRKDC STAG2	2.78e-04	394	51	5	27248496
Pubmed	Jmjd3 Plays Pivotal Roles in the Proper Development of Early-Born Retinal Lineages: Amacrine, Horizontal, and Retinal Ganglion Cells.	POU4F2 ADCY3	2.83e-04	17	51	2	32986815
Pubmed	Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system.	GAD2 POU4F2	3.18e-04	18	51	2	24799694
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	METTL13 TOGARAM1 KLHL8 CLEC16A	3.36e-04	225	51	4	12168954
Pubmed	Gene essentiality and synthetic lethality in haploid human cells.	COG6 SMARCB1 ARMH3 CLEC16A	3.59e-04	229	51	4	26472760
Pubmed	Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina.	GAD2 POU4F2	3.94e-04	20	51	2	16026391
Interaction	C3orf18 interactions	ATP13A1 INTS1 PRKDC ZW10 ARMH3 STAG2	3.47e-07	115	49	6	int:C3orf18
Interaction	SMIM2 interactions	UBQLN2 UBQLN1	1.73e-05	3	49	2	int:SMIM2
Interaction	DEFB115 interactions	UBQLN2 UBQLN1	1.73e-05	3	49	2	int:DEFB115
Interaction	DMKN interactions	GAD2 UBQLN2 UBQLN1	2.99e-05	25	49	3	int:DMKN
Interaction	APOC4 interactions	GAD2 UBQLN2 UBQLN1	3.79e-05	27	49	3	int:APOC4
Interaction	OR4N2 interactions	S100A10 UBQLN2 UBQLN1	4.72e-05	29	49	3	int:OR4N2
Interaction	UGT1A3 interactions	UGT1A3 UGT1A5	5.76e-05	5	49	2	int:UGT1A3
Interaction	GUCA2B interactions	UBQLN2 UBQLN1	5.76e-05	5	49	2	int:GUCA2B
Interaction	GPR17 interactions	WASHC4 COG6 INTS1 PRKDC ZW10 STAG2	6.12e-05	283	49	6	int:GPR17
Interaction	KIR2DL4 interactions	ATP13A1 PRKDC ZW10 STAG2	8.01e-05	94	49	4	int:KIR2DL4
Interaction	ILVBL interactions	UBQLN2 COG6 INTS1 ZW10 CLEC16A	8.06e-05	183	49	5	int:ILVBL
Interaction	C1QTNF4 interactions	UBQLN2 UBQLN1	8.63e-05	6	49	2	int:C1QTNF4
Interaction	SMIM19 interactions	UBQLN2 UBQLN1	1.21e-04	7	49	2	int:SMIM19
Interaction	COMTD1 interactions	UBQLN1 COG6 INTS1 ZW10 STAG2	1.22e-04	200	49	5	int:COMTD1
Interaction	APOC2 interactions	GAD2 UBQLN2 UBQLN1	1.25e-04	40	49	3	int:APOC2
Interaction	F10 interactions	GAD2 UBQLN2 F5	1.56e-04	43	49	3	int:F10
Interaction	GPR162 interactions	UBQLN2 UBQLN1	1.61e-04	8	49	2	int:GPR162
Interaction	WFDC12 interactions	UBQLN2 UBQLN1	1.61e-04	8	49	2	int:WFDC12
Interaction	LY6G6D interactions	UBQLN2 RNF139	2.06e-04	9	49	2	int:LY6G6D
Interaction	FAM234A interactions	COG6 PRKDC ZW10 STAG2	2.48e-04	126	49	4	int:FAM234A
Interaction	IGFBP6 interactions	UBQLN2 UBQLN1 POU4F2	2.59e-04	51	49	3	int:IGFBP6
Interaction	EFNA4 interactions	COG6 INTS1 PRKDC ZW10 STAG2	2.80e-04	239	49	5	int:EFNA4
Interaction	SEZ6L interactions	UBQLN2 UBQLN1	3.14e-04	11	49	2	int:SEZ6L
Interaction	RTL8A interactions	UBQLN2 UBQLN1	3.14e-04	11	49	2	int:RTL8A
Interaction	PAQR9 interactions	UBQLN2 UBQLN1	3.14e-04	11	49	2	int:PAQR9
Interaction	PLAAT3 interactions	UBQLN2 UBQLN1	3.14e-04	11	49	2	int:PLAAT3
Interaction	MTNR1B interactions	UBQLN2 INTS1 PRKDC ADCY3	3.23e-04	135	49	4	int:MTNR1B
Interaction	ZMYM3 interactions	NOL4 UBQLN2 UBQLN1 ZSCAN5A	3.42e-04	137	49	4	int:ZMYM3
Cytoband	19q13.43	ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C	2.81e-06	87	51	4	19q13.43
Cytoband	2q37	UGT1A4 UGT1A3 UGT1A5	5.68e-06	31	51	3	2q37
Cytoband	Ensembl 112 genes in cytogenetic band chr12q23	WASHC4 APPL2 TCP11L2 NR1H4	2.43e-05	150	51	4	chr12q23
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	NAA35 TMC1 UBQLN1	1.43e-03	199	51	3	chr9q21
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	UGT1A4 UGT1A3 UGT1A5	2.06e-03	226	51	3	chr2q37
Cytoband	Ensembl 112 genes in cytogenetic band chr4q22	ABCG2 KLHL8	3.11e-03	74	51	2	chr4q22
Cytoband	22q13.1	MYH9 CACNA1I	4.07e-03	85	51	2	22q13.1
GeneFamily	UDP glucuronosyltransferases	UGT1A4 UGT1A3 UGT1A5	4.07e-05	32	38	3	363
GeneFamily	Ubiquilin family	UBQLN2 UBQLN1	4.28e-05	5	38	2	783
Drug	4-methylumbelliferyl glucuronide	UGT1A4 UGT1A3 GAD2 UGT1A5 ABCG2	1.98e-08	38	50	5	CID000091553
Drug	9-OH-risperidone	UGT1A4 UGT1A3 UGT1A5 ABCG2	7.78e-08	19	50	4	CID000475100
Drug	tectochrysin	UGT1A4 UGT1A3 UGT1A5 ABCG2	9.71e-08	20	50	4	CID005281954
Drug	H-Ni	UGT1A4 UGT1A3 UGT1A5 PRKDC	4.05e-07	28	50	4	CID000445665
Drug	4-ethylphenol	UGT1A4 UGT1A3 UGT1A5 MAPK13	6.20e-07	31	50	4	CID000031242
Drug	AC1MRQNQ	UGT1A4 UGT1A3 UGT1A5	8.29e-07	9	50	3	CID003522271
Drug	DHPASiU	UGT1A4 UGT1A3 UGT1A5	8.29e-07	9	50	3	CID000197602
Drug	Chebi:32663	UGT1A4 UGT1A3 UGT1A5	8.29e-07	9	50	3	CID005460873
Drug	3-iodophenol	UGT1A4 UGT1A3 UGT1A5	8.29e-07	9	50	3	CID000012272
Drug	AC1L4J7U	UGT1A4 UGT1A3 UGT1A5	8.29e-07	9	50	3	CID000186631
Drug	acacetin	UGT1A4 UGT1A3 UGT1A5 ABCG2	1.44e-06	38	50	4	CID005280442
Drug	4-nitrophenyl)imidazole	UGT1A4 UGT1A3 UGT1A5	1.62e-06	11	50	3	CID000123155
Drug	AC1O5XMV	UGT1A4 UGT1A3 UGT1A5	1.62e-06	11	50	3	CID006442661
Drug	harmol	UGT1A4 UGT1A3 UGT1A5 ABCG2	1.77e-06	40	50	4	CID000068094
Drug	AC1Q6O8B	UGT1A4 UGT1A3 UGT1A5 NR1H4	1.96e-06	41	50	4	CID000000334
Drug	TCPOBOP	UGT1A4 UGT1A3 UGT1A5 ABCG2 NR1H4	2.08e-06	95	50	5	CID000005382
Drug	N-OH-DABZ	UGT1A4 UGT1A3 UGT1A5	2.16e-06	12	50	3	CID000051366
Drug	1-O-beta-D-glucopyranosyl-D-mannitol	UGT1A4 UGT1A3 UGT1A5	2.16e-06	12	50	3	CID000088735
Drug	2,4,6-TCB	UGT1A4 UGT1A3 UGT1A5	2.16e-06	12	50	3	CID000037247
Drug	7,7,7-triphenylheptanoic acid	UGT1A4 UGT1A3 UGT1A5	2.16e-06	12	50	3	CID000276709
Drug	nonanoyl-N-methylglucamide	UGT1A4 UGT1A3 UGT1A5	2.16e-06	12	50	3	CID000160090
Drug	L 654969	UGT1A4 UGT1A3 UGT1A5 ABCG2	2.17e-06	42	50	4	CID000005218
Drug	kaempferol	UGT1A4 UGT1A3 UGT1A5 ABCG2 STAG2	2.30e-06	97	50	5	CID005280863
Drug	tritanol	UGT1A4 UGT1A3 UGT1A5	2.81e-06	13	50	3	CID000006457
Drug	5-azido-UDP-glucuronic acid	UGT1A4 UGT1A3 UGT1A5	2.81e-06	13	50	3	CID003081279
Drug	cotinine-N-glucuronide	UGT1A4 UGT1A3 UGT1A5	2.81e-06	13	50	3	CID000000411
Drug	propranolol glucuronide	UGT1A4 UGT1A3 UGT1A5	3.57e-06	14	50	3	CID000119515
Drug	PCB-61	UGT1A4 UGT1A3 UGT1A5	3.57e-06	14	50	3	CID000036401
Drug	AC1L1G0K	UGT1A4 UGT1A3 UGT1A5 MAPK13	4.05e-06	49	50	4	CID000003473
Drug	2,2',3,5,5'-pentachlorobiphenyl	UGT1A4 UGT1A3 UGT1A5	4.45e-06	15	50	3	CID000040469
Drug	coumarin-3-carboxylic acid	UGT1A4 UGT1A3 UGT1A5	4.45e-06	15	50	3	CID000010752
Drug	sulforaphane nitrile	UGT1A4 UGT1A3 UGT1A5	4.45e-06	15	50	3	CID000543743
Drug	afloqualone	UGT1A4 UGT1A3 UGT1A5	4.45e-06	15	50	3	CID000002040
Drug	naphthyl sulphate	UGT1A4 UGT1A3 UGT1A5	4.45e-06	15	50	3	CID000114775
Drug	afloqualone	UGT1A4 UGT1A3	4.73e-06	2	50	2	ctd:C033541
Drug	albendazole sulfoxide	ABCG2 NR1H4	4.73e-06	2	50	2	ctd:C027186
Drug	(+/-)-Abacavir	UGT1A4 UGT1A3 UGT1A5 ABCG2	4.77e-06	51	50	4	CID000001971
Drug	quercetin-3,4'-diglucoside	UGT1A4 UGT1A3 UGT1A5	5.47e-06	16	50	3	CID005320835
Drug	1'-hydroxyestragole	UGT1A4 UGT1A3 UGT1A5	5.47e-06	16	50	3	CID000040003
Drug	bilirubin-phosphate	UGT1A4 UGT1A3 UGT1A5	5.47e-06	16	50	3	CID005497144
Drug	tangeretin	UGT1A4 UGT1A3 UGT1A5 MAPK13	6.00e-06	54	50	4	CID000068077
Drug	3 beta,5 alpha,25R)- 3-hydroxyspirostan-12-one	UGT1A4 UGT1A3 UGT1A5	6.63e-06	17	50	3	CID000003573
Drug	6-hydroxychrysene	UGT1A4 UGT1A3 UGT1A5	6.63e-06	17	50	3	CID000037766
Drug	Invader	UGT1A4 UGT1A3 UGT1A5 F5	6.95e-06	56	50	4	CID006442259
Drug	flavopiridol	UGT1A4 UGT1A3 UGT1A5 SMARCB1 ABCG2 MAPK13	7.63e-06	216	50	6	CID005287969
Drug	ethyl-beta-D-6-glucosiduronic acid	UGT1A4 UGT1A3 UGT1A5	7.94e-06	18	50	3	CID000152226
Drug	Br 2	UGT1A4 UGT1A3 UGT1A5	7.94e-06	18	50	3	CID003060900
Drug	SureCN12722713	UGT1A4 UGT1A3 UGT1A5	7.94e-06	18	50	3	CID005488034
Drug	2,3,7-trichlorodibenzo-p-dioxin	UGT1A4 UGT1A3 UGT1A5	7.94e-06	18	50	3	CID000036614
Drug	ApApG	UGT1A4 UGT1A3 UGT1A5	7.94e-06	18	50	3	CID003081975
Drug	C1 11-32	UGT1A4 UGT1A3 UGT1A5	7.94e-06	18	50	3	CID000443077
Drug	C11131	UGT1A4 UGT1A3 UGT1A5	7.94e-06	18	50	3	CID000443076
Drug	SN-38G	UGT1A4 UGT1A3 UGT1A5 ABCG2	8.57e-06	59	50	4	CID000443154
Drug	almokalant	UGT1A4 UGT1A3 UGT1A5	9.42e-06	19	50	3	CID003033962
Drug	5alpha-spirostan-3beta-ol	UGT1A4 UGT1A3 UGT1A5	9.42e-06	19	50	3	CID000091433
Drug	AC1L1OBF	UGT1A4 UGT1A3 UGT1A5	1.11e-05	20	50	3	CID000032736
Drug	4'-hydroxydiclofenac	UGT1A4 UGT1A3 UGT1A5	1.11e-05	20	50	3	CID000116545
Drug	naringenin	UGT1A4 UGT1A3 UGT1A5 ABCG2 STAG2	1.21e-05	136	50	5	CID000000932
Drug	estriol-16-glucuronide	UGT1A4 UGT1A3 UGT1A5	1.29e-05	21	50	3	CID000122281
Drug	dulcin	UGT1A4 UGT1A3 UGT1A5	1.29e-05	21	50	3	CID000009013
Drug	Benzamidoxime hydrochloride	UGT1A4 UGT1A3 UGT1A5	1.29e-05	21	50	3	CID000069186
Drug	pregnenolone-16 alpha-carbonitrile	UGT1A4 UGT1A3 UGT1A5 NR1H4	1.42e-05	67	50	4	CID000015032
Drug	TBHQ	UGT1A4 UGT1A3 UGT1A5 ABCG2 NR1H4	1.44e-05	141	50	5	CID000016043
Drug	amonafide	UGT1A4 UGT1A3 UGT1A5	1.49e-05	22	50	3	CID000050515
Drug	N-methylpiperazine	UGT1A4 UGT1A3 UGT1A5	1.49e-05	22	50	3	CID000053167
Drug	amidoxime	UGT1A4 UGT1A3 UGT1A5	1.71e-05	23	50	3	CID000465967
Drug	estradiol-3-glucuronide	UGT1A4 UGT1A3 UGT1A5	1.71e-05	23	50	3	CID000066651
Drug	phenanthridine	UGT1A4 UGT1A3 UGT1A5	1.71e-05	23	50	3	CID000009189
Drug	AS-3201	UGT1A4 UGT1A3 UGT1A5	1.95e-05	24	50	3	CID000153948
Drug	AC1L7AJI	UGT1A4 UGT1A3 UGT1A5 BUB1 ABCG2 PRKDC	2.00e-05	256	50	6	CID000003750
Drug	eugenol	UGT1A4 UGT1A3 UGT1A5 SMARCB1	2.00e-05	73	50	4	CID000003314
Drug	5-MOP	UGT1A4 UGT1A3 UGT1A5	2.22e-05	25	50	3	CID000002355
Drug	AzMC	UGT1A4 UGT1A3 UGT1A5	2.22e-05	25	50	3	CID000064986
Drug	N-acetylbenzidine	UGT1A4 UGT1A3 UGT1A5	2.22e-05	25	50	3	CID000018787
Drug	5,6-benzoquinoline	UGT1A4 UGT1A3 UGT1A5	2.22e-05	25	50	3	CID000006796
Drug	N-phenylmaleimide	UGT1A4 UGT1A3 UGT1A5	2.22e-05	25	50	3	CID000013662
Drug	N-benzylformamide	UGT1A4 UGT1A3 UGT1A5 F5	2.35e-05	76	50	4	CID000080654
Drug	DiMeIQx	UGT1A4 UGT1A3 UGT1A5	2.81e-05	27	50	3	CID000104739
Drug	Farnesol	UGT1A4 UGT1A3 NR1H4	2.81e-05	27	50	3	ctd:D005204
Drug	diflunisal	UGT1A4 UGT1A3 UGT1A5	2.81e-05	27	50	3	CID000003059
Drug	N-hydroxy-4-aminobiphenyl	UGT1A4 UGT1A3 UGT1A5	3.14e-05	28	50	3	CID000081261
Drug	CARMINE	UGT1A4 UGT1A3 UGT1A5	3.14e-05	28	50	3	CID000014749
Drug	erucin	UGT1A4 UGT1A3 UGT1A5	3.14e-05	28	50	3	CID000078160
Drug	5 alpha-androstane	UGT1A4 UGT1A3 UGT1A5 NR1H4	3.49e-05	84	50	4	CID000094144
Drug	AC1L1JAL	UGT1A4 UGT1A3 UGT1A5	3.50e-05	29	50	3	CID000004954
Drug	7-hydroxy-4-trifluoromethylcoumarin	UGT1A4 UGT1A3 UGT1A5	3.50e-05	29	50	3	CID005375667
Drug	trans-3'-hydroxycotinine	UGT1A4 UGT1A3 UGT1A5	3.50e-05	29	50	3	CID000000414
Drug	7-hydroxycoumarin glucuronide	UGT1A4 UGT1A3 UGT1A5	3.50e-05	29	50	3	CID000125641
Drug	iberin	UGT1A4 UGT1A3 UGT1A5	3.50e-05	29	50	3	CID000010455
Drug	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	UGT1A4 UGT1A3 ABCG2	3.50e-05	29	50	3	ctd:C060533
Drug	diosmetin	UGT1A4 UGT1A3 UGT1A5 ABCG2	3.65e-05	85	50	4	CID005281612
Drug	tolcapone	UGT1A4 UGT1A3 UGT1A5	3.88e-05	30	50	3	CID004659569
Drug	paricalcitol	UGT1A4 UGT1A3 UGT1A5	3.88e-05	30	50	3	CID005281104
Drug	AC1L9E0Q	UGT1A4 UGT1A3 UGT1A5	3.88e-05	30	50	3	CID000443095
Drug	dihydroartemisinin	UGT1A4 UGT1A3 UGT1A5	3.88e-05	30	50	3	CID000107770
Drug	sulfinpyrazone	UGT1A4 UGT1A3 UGT1A5 ABCG2	4.00e-05	87	50	4	CID000005342
Drug	PCB 156	UGT1A4 UGT1A3 UGT1A5	4.29e-05	31	50	3	CID000038019
Drug	4'-HPPH	UGT1A4 UGT1A3 UGT1A5	4.29e-05	31	50	3	CID000017732
Drug	indole-2-carboxylic acid	UGT1A4 UGT1A3 UGT1A5	4.73e-05	32	50	3	CID000072899
Drug	NNAL	UGT1A4 UGT1A3 UGT1A5	4.73e-05	32	50	3	CID000104856
Disease	sulfate of piperine metabolite C18H21NO3 (3) measurement	UGT1A4 UGT1A3 UGT1A5 ABCG2	7.08e-10	9	47	4	EFO_0801037
Disease	sulfate of piperine metabolite C18H21NO3 (1) measurement	UGT1A4 UGT1A3 UGT1A5 ABCG2	7.08e-10	9	47	4	EFO_0801036
Disease	X-11793--oxidized bilirubin measurement	UGT1A4 UGT1A3 UGT1A5	2.11e-07	8	47	3	EFO_0021260
Disease	Succinimide measurement	UGT1A4 UGT1A3 UGT1A5	2.11e-07	8	47	3	EFO_0022118
Disease	X-11530 measurement	UGT1A4 UGT1A3 UGT1A5	2.11e-07	8	47	3	EFO_0021249
Disease	sulfate of piperine metabolite C16H19NO3 (2) measurement	UGT1A4 UGT1A3 UGT1A5	2.11e-07	8	47	3	EFO_0801034
Disease	cholelithiasis, bilirubin measurement	UGT1A4 UGT1A3 UGT1A5	2.11e-07	8	47	3	EFO_0004570, EFO_0004799
Disease	X-11522 measurement	UGT1A4 UGT1A3 UGT1A5	2.11e-07	8	47	3	EFO_0800696
Disease	X-10458 measurement	UGT1A4 UGT1A3 UGT1A5	2.11e-07	8	47	3	EFO_0800692
Disease	X-24849 measurement	UGT1A4 UGT1A3 UGT1A5	2.11e-07	8	47	3	EFO_0800909
Disease	membrane-associated progesterone receptor component 1 measurement	UGT1A4 UGT1A3 UGT1A5	2.11e-07	8	47	3	EFO_0802740
Disease	X-16946 measurement	UGT1A4 UGT1A3 UGT1A5	2.11e-07	8	47	3	EFO_0800766
Disease	X-11442 measurement	UGT1A4 UGT1A3 UGT1A5	3.16e-07	9	47	3	EFO_0021236
Disease	X-11441 measurement	UGT1A4 UGT1A3 UGT1A5	3.16e-07	9	47	3	EFO_0021235
Disease	circulating cell free DNA measurement	UGT1A4 UGT1A3 UGT1A5	3.16e-07	9	47	3	EFO_0004739
Disease	testis-specific chromodomain protein Y 1 measurement	UGT1A4 UGT1A3 UGT1A5	3.16e-07	9	47	3	EFO_0802127
Disease	X-11880 measurement	UGT1A4 UGT1A3 UGT1A5	3.16e-07	9	47	3	EFO_0800698
Disease	bilirubin measurement, response to xenobiotic stimulus	UGT1A4 UGT1A3 UGT1A5	3.16e-07	9	47	3	EFO_0004570, GO_0009410
Disease	protein-tyrosine kinase 6 measurement	UGT1A4 UGT1A3 UGT1A5	3.16e-07	9	47	3	EFO_0020691
Disease	X-21448 measurement	UGT1A4 UGT1A3 UGT1A5	4.51e-07	10	47	3	EFO_0800816
Disease	UDP-glucuronosyltransferase 1-6 measurement	UGT1A4 UGT1A3 UGT1A5	4.51e-07	10	47	3	EFO_0802185
Disease	X-23974 measurement	UGT1A4 UGT1A3 UGT1A5	4.51e-07	10	47	3	EFO_0800867
Disease	bilirubin measurement, response to tenofovir	UGT1A4 UGT1A3 UGT1A5	4.51e-07	10	47	3	EFO_0004570, EFO_0009279
Disease	X-21796 measurement	UGT1A4 UGT1A3 UGT1A5	6.19e-07	11	47	3	EFO_0800825
Disease	insomnia, bilirubin measurement	UGT1A4 UGT1A3 UGT1A5	6.19e-07	11	47	3	EFO_0004570, EFO_0004698
Disease	histidine betaine (hercynine) measurement	UGT1A4 UGT1A3 UGT1A5	6.19e-07	11	47	3	EFO_0800972
Disease	aldosterone measurement	UGT1A4 UGT1A3 UGT1A5	6.19e-07	11	47	3	EFO_0010219
Disease	biliverdin measurement	UGT1A4 UGT1A3 UGT1A5	8.25e-07	12	47	3	EFO_0021033
Disease	p-cresol glucuronide measurement	UGT1A4 UGT1A3 UGT1A5	8.25e-07	12	47	3	EFO_0800079
Disease	retinol dehydrogenase 16 measurement	UGT1A4 UGT1A3 UGT1A5	1.07e-06	13	47	3	EFO_0802007
Disease	low density lipoprotein cholesterol measurement, body fat percentage	UGT1A4 UGT1A3 UGT1A5	2.54e-06	17	47	3	EFO_0004611, EFO_0007800
Disease	angiopoietin-related protein 1 measurement	UGT1A4 UGT1A3 UGT1A5	3.04e-06	18	47	3	EFO_0801382
Disease	tissue factor measurement	UGT1A4 UGT1A3 UGT1A5	4.94e-06	21	47	3	EFO_0010623
Disease	amyotrophic lateral sclerosis type 15 (implicated_via_orthology)	UBQLN2 UBQLN1	7.44e-06	3	47	2	DOID:0060206 (implicated_via_orthology)
Disease	xanthurenate measurement	UGT1A4 UGT1A3 UGT1A5	1.34e-05	29	47	3	EFO_0010551
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	UBQLN2 UBQLN1 EPG5	1.49e-05	30	47	3	DOID:332 (implicated_via_orthology)
Disease	response to dolutegravir	UGT1A4 UGT1A3 UGT1A5	1.49e-05	30	47	3	EFO_0600017
Disease	sensorineural hearing loss (is_implicated_in)	MYH9 TMC1 F5	2.00e-05	33	47	3	DOID:10003 (is_implicated_in)
Disease	neutrophil percentage of granulocytes	WDR36 COG6 AKAP13 PRKDC CLEC16A	3.10e-05	228	47	5	EFO_0007994
Disease	eosinophil percentage of granulocytes	WDR36 COG6 AKAP13 PRKDC CLEC16A	3.51e-05	234	47	5	EFO_0007996
Disease	gout (is_implicated_in)	A1CF ABCG2	3.71e-05	6	47	2	DOID:13189 (is_implicated_in)
Disease	urate measurement, spine bone mineral density	UGT1A4 UGT1A3 UGT1A5	1.10e-04	58	47	3	EFO_0004531, EFO_0007701
Disease	pregnenetriol sulfate measurement	UGT1A4 UGT1A5	1.35e-04	11	47	2	EFO_0800586
Disease	plasma N-desmethylclozapine measurement	UGT1A4 UGT1A5	1.35e-04	11	47	2	EFO_0600039
Disease	frontotemporal dementia (implicated_via_orthology)	UBQLN2 UBQLN1	1.62e-04	12	47	2	DOID:9255 (implicated_via_orthology)
Disease	pregnenetriol disulfate measurement	UGT1A4 UGT1A5	1.92e-04	13	47	2	EFO_0800587
Disease	thyroxine measurement	UGT1A4 UGT1A3 UGT1A5	3.18e-04	83	47	3	EFO_0005130
Disease	hormone measurement	UGT1A4 UGT1A3 UGT1A5	3.30e-04	84	47	3	EFO_0004730
Disease	X-21441 measurement	UGT1A4 UGT1A5	3.33e-04	17	47	2	EFO_0800814
Disease	rhinitis	WDR36 CLEC16A	3.33e-04	17	47	2	EFO_0008521
Disease	cholelithiasis	UGT1A4 UGT1A3 UGT1A5	3.78e-04	88	47	3	EFO_0004799
Disease	basophil count, eosinophil count	WDR36 COG6 PRKDC CLEC16A	5.88e-04	241	47	4	EFO_0004842, EFO_0005090
Disease	Sensorineural Hearing Loss (disorder)	MYH9 TMC1	6.15e-04	23	47	2	C0018784
Disease	bilirubin measurement	UGT1A4 UGT1A3 A1CF UGT1A5 KLHL8	6.74e-04	442	47	5	EFO_0004570
Disease	gallstones	UGT1A4 UGT1A3 UGT1A5	6.88e-04	108	47	3	EFO_0004210
Disease	adult onset asthma	WDR36 COG6 CLEC16A	8.89e-04	118	47	3	EFO_1002011
Disease	non-high density lipoprotein cholesterol measurement	UGT1A4 UGT1A3 A1CF APPL2 UGT1A5 NR1H4	9.01e-04	713	47	6	EFO_0005689
Disease	Autosomal dominant nonsyndromic hearing loss	MYH9 TMC1	9.81e-04	29	47	2	cv:C5779548
Disease	hip bone mineral density	ZSCAN5A TTC21B IQCJ-SCHIP1	1.07e-03	126	47	3	EFO_0007702
Disease	social communication impairment	TTC21B CLEC16A	1.19e-03	32	47	2	EFO_0005427
Disease	asthma, seasonal allergic rhinitis	WDR36 CLEC16A	1.19e-03	32	47	2	EFO_0003956, MONDO_0004979
Disease	seasonal allergic rhinitis	WDR36 CLEC16A	1.19e-03	32	47	2	EFO_0003956
Disease	chronic rhinosinusitis	WDR36 CLEC16A	1.35e-03	34	47	2	EFO_1000024
Disease	nasal disorder	WDR36 CLEC16A	1.43e-03	35	47	2	MONDO_0002436

Protein segments in the cluster

Peptide	Gene	Start	Entry
MMPLFGDQMDNAKRM	UGT1A3	391	P35503
MMMADLMFRKQDYEQ	TTC21B	956	Q7Z4L5
MEVLMMMNNATIPTA	EPG5	2271	Q9HCE0
QLMERLKPSMQHMFM	BUB1	836	O43683
KIYEMRMMMDFNGNN	A1CF	81	Q9NQ94
MAMAMQMATFAINYK	ATP13A1	1106	Q9HD20
PKADAFFVMMFTLMM	ABCG2	501	Q9UNQ0
LKQMDSLMPLMMTAQ	AKAP13	291	Q12802
MVEFIVTHMMKEFPM	ARMH3	451	Q5T2E6
FMEMMSMKPAKGVLT	NR1H4	26	Q96RI1
SNMYAMMIARFKMFP	GAD2	246	Q05329
PTLKMLMEMVMTNNY	INTS1	761	Q8N201
AKMTEVMMNTQPMEE	LBH	16	Q53QV2
GSMEMFDPLTNKWMM	KLHL8	381	Q9P2G9
VMPFMQTDLQKIMGM	MAPK13	106	O15264
KDMFQETMEAMRIMG	MYH9	316	P35579
DMATFMVNSLYMMKT	COG6	496	Q9Y2V7
MKTMDNVATFCMLLM	CACNA1I	756	Q9P0X4
LMMTQMSKYAMPSST	BCL9L	1086	Q86UU0
VPSKYSMTVMVFLMM	ADCY3	836	O60266
NALQYRKQMAMMEPM	APPL2	186	Q8NEU8
PQMSFLKMDMTQMEF	METTL13	96	Q8N6R0
MNSFLPMESCTFMVM	OR56A1	111	Q8NGH5
NQYSSLMIMMAMAMK	MT-ND2	91	P03891
TMMFESGSKIRAFMM	RNF139	486	Q8WU17
MQMDMANFTIMSLRP	TCP11L2	221	Q8N4U5
NMPMDMREFVLLFMT	F5	1761	P12259
MMMMSLNSKQAFSMP	POU4F2	1	Q12837
MMMMALSKTFGQKPV	SMARCB1	1	Q12824
MALAMAKPMAKMQVE	IQCJ-SCHIP1	446	B3KU38
GMSVMNKDMDLQMSF	MROH2B	741	Q7Z745
NMPITMAYMKHMKLQ	NOL4	191	O94818
MPSQMEHAMETMMFT	S100A10	1	P60903
KNEMNMVMSLLGMFC	TMC1	406	Q8TDI8
MTMKPMNVEYLMMDA	CLEC16A	621	Q2KHT3
LDMLVMEQFMISMPQ	ZSCAN5DP	81	P0CG00
LFEAMSAIEMMDPKM	NAA35	56	Q5VZE5
NMMLFEVVKMGKSAM	STAG2	81	Q8N3U4
MQNMLSAPYMRSMMQ	UBQLN1	391	Q9UMX0
MLVMEQFMISMPQEL	ZSCAN5B	86	A6NJL1
MLVMEQFMISMPQEL	ZSCAN5A	86	Q9BUG6
MMPLFGDQMDNAKRM	UGT1A5	391	P35504
SMVMFMLGKATQMPE	PRKDC	936	P78527
TTMNLYMSMQKPMTK	WASHC4	456	Q2M389
MMIQIMENPFVQSML	UBQLN2	181	Q9UHD9
MLFFMMCHPNFEKML	TOGARAM1	1391	Q9Y4F4
MLVMEQFMISMPQEL	ZSCAN5C	86	A6NGD5
MGETMQSRFSMMPQS	TDH	201	Q8IZJ6
MPFKELMMMLQASLQ	ZW10	721	O43264
EVMQSFLKMIGMMLD	WDR36	871	Q8NI36
MMPLFGDQMDNAKRM	UGT1A4	391	P22310
AMQSFMMPFYLMKDC	WBP2	66	Q969T9