Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine N-sulfotransferase activity	NDST4 NDST3 NDST1	5.21e-08	4	48	3	GO:0015016
GeneOntologyMolecularFunction	N-acetylglucosamine deacetylase activity	NDST4 NDST3 NDST1	5.21e-08	4	48	3	GO:0050119
GeneOntologyMolecularFunction	heparan sulfate sulfotransferase activity	NDST4 NDST3 NDST1	5.81e-06	15	48	3	GO:0034483
GeneOntologyMolecularFunction	heparan sulfate N-deacetylase activity	NDST3 NDST1	1.69e-05	3	48	2	GO:0102140
GeneOntologyMolecularFunction	histone H3K9me2/H3K9me3 demethylase activity	KDM4A KDM4C	8.44e-05	6	48	2	GO:0140684
GeneOntologyMolecularFunction	deacetylase activity	NDST4 NDST3 NDST1	1.21e-04	40	48	3	GO:0019213
GeneOntologyMolecularFunction	histone H3K36 demethylase activity	KDM4A KDM4C	3.07e-04	11	48	2	GO:0051864
GeneOntologyMolecularFunction	sulfotransferase activity	NDST4 NDST3 NDST1	3.13e-04	55	48	3	GO:0008146
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM4A KDM4C	5.06e-04	14	48	2	GO:0032454
GeneOntologyMolecularFunction	transferase activity, transferring sulphur-containing groups	NDST4 NDST3 NDST1	7.50e-04	74	48	3	GO:0016782
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	NDST4 NDST3 NDST1	9.75e-04	81	48	3	GO:0016811
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM4A KDM4C	2.06e-03	28	48	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM4A KDM4C	2.52e-03	31	48	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM4A KDM4C	2.68e-03	32	48	2	GO:0140457
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	NDST4 NDST3 NDST1	5.77e-07	8	46	3	GO:0015014
GeneOntologyBiologicalProcess	heparin biosynthetic process	NDST4 NDST3 NDST1	1.69e-06	11	46	3	GO:0030210
GeneOntologyBiologicalProcess	heparin metabolic process	NDST4 NDST3 NDST1	6.91e-06	17	46	3	GO:0030202
GeneOntologyBiologicalProcess	proteoglycan biosynthetic process	NDST4 NDST3 NDST1 BMPR2	1.78e-05	70	46	4	GO:0030166
GeneOntologyBiologicalProcess	proteoglycan metabolic process	NDST4 NDST3 NDST1 BMPR2	6.45e-05	97	46	4	GO:0006029
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process	NDST4 NDST3 NDST1	6.46e-05	35	46	3	GO:0015012
GeneOntologyBiologicalProcess	polysaccharide metabolic process	NDST4 NDST3 NDST1 LEPR	1.78e-04	126	46	4	GO:0005976
GeneOntologyCellularComponent	side of membrane	ERMAP KCNMA1 CD59 TRAF5 THADA ICOS LEPR LRRK2 GP2	1.46e-04	875	48	9	GO:0098552
GeneOntologyCellularComponent	Golgi membrane	NDST4 NDST3 CD59 NDST1 RASGRP1 GALNT7 LRRK2 CNIH1	2.14e-04	721	48	8	GO:0000139
Domain	HSNSD	NDST4 NDST3 NDST1	5.58e-08	4	46	3	PF12062
Domain	Heparan_SO4_deacetylase	NDST4 NDST3 NDST1	5.58e-08	4	46	3	IPR021930
Domain	EPHD	KDM4A BRPF3 KDM4C	2.08e-05	22	46	3	PS51805
Domain	Sulfotransferase_dom	NDST4 NDST3 NDST1	9.43e-05	36	46	3	IPR000863
Domain	Sulfotransfer_1	NDST4 NDST3 NDST1	9.43e-05	36	46	3	PF00685
Domain	JmjN	KDM4A KDM4C	2.64e-04	10	46	2	SM00545
Domain	JMJN	KDM4A KDM4C	2.64e-04	10	46	2	PS51183
Domain	JmjN	KDM4A KDM4C	2.64e-04	10	46	2	PF02375
Domain	JmjN	KDM4A KDM4C	2.64e-04	10	46	2	IPR003349
Domain	-	KDM4A BRPF3 TRAF5 KDM4C TRIM5 RNF146	7.74e-04	449	46	6	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KDM4A BRPF3 TRAF5 KDM4C TRIM5 RNF146	8.68e-04	459	46	6	IPR013083
Domain	PHD	KDM4A BRPF3 KDM4C	1.37e-03	89	46	3	SM00249
Domain	TUDOR	KDM4A KDM4C	1.45e-03	23	46	2	PS50304
Domain	Znf_PHD	KDM4A BRPF3 KDM4C	1.46e-03	91	46	3	IPR001965
Domain	JmjC	KDM4A KDM4C	1.58e-03	24	46	2	PF02373
Domain	ZF_PHD_2	KDM4A BRPF3 KDM4C	1.65e-03	95	46	3	PS50016
Domain	ZF_PHD_1	KDM4A BRPF3 KDM4C	1.70e-03	96	46	3	PS01359
Domain	TUDOR	KDM4A KDM4C	2.00e-03	27	46	2	SM00333
Domain	Tudor	KDM4A KDM4C	2.47e-03	30	46	2	IPR002999
Domain	JMJC	KDM4A KDM4C	2.81e-03	32	46	2	PS51184
Domain	JmjC_dom	KDM4A KDM4C	2.81e-03	32	46	2	IPR003347
Domain	JmjC	KDM4A KDM4C	2.98e-03	33	46	2	SM00558
Domain	PROTEIN_KINASE_ATP	NEK1 BMPR2 BMP2K EPHA7 LRRK2	5.25e-03	459	46	5	PS00107
Domain	Znf_FYVE_PHD	KDM4A BRPF3 KDM4C	5.66e-03	147	46	3	IPR011011
Pathway	KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS	NDST4 NDST3 NDST1	2.28e-06	11	35	3	M47921
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE	NDST4 NDST3 NDST1	3.51e-05	26	35	3	M7330
Pathway	REACTOME_HS_GAG_BIOSYNTHESIS	NDST4 NDST3 NDST1	4.90e-05	29	35	3	MM14802
Pathway	REACTOME_HS_GAG_BIOSYNTHESIS	NDST4 NDST3 NDST1	6.01e-05	31	35	3	M685
Pathway	WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS	NDST4 NDST3 NDST1	1.40e-04	41	35	3	M48095
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	NDST4 NDST3 NDST1	3.19e-04	54	35	3	MM14633
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	NDST4 NDST3 NDST1	3.74e-04	57	35	3	M692
Pubmed	Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.	NDST4 NDST3 NDST1	9.86e-09	4	48	3	22049073
Pubmed	Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.	NDST4 NDST3 NDST1	9.86e-09	4	48	3	12070138
Pubmed	Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.	NDST4 NDST3 NDST1	2.46e-08	5	48	3	11087757
Pubmed	FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.	NDST4 NDST3 NDST1	1.37e-07	8	48	3	24067353
Pubmed	Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.	NDST4 NDST3 NDST1	4.04e-07	11	48	3	15944372
Pubmed	Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.	NDST4 NDST3 NDST1	5.38e-07	12	48	3	12460940
Pubmed	Involvement of ObRb receptor, nitric oxide, and BKCa channel signaling pathways in leptin-induced relaxation of pregnant mouse uterus.	KCNMA1 LEPR	1.87e-06	2	48	2	38945286
Pubmed	Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy.	KDM4A KDM4C	1.87e-06	2	48	2	23692052
Pubmed	Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.	NDST4 NDST3 NDST1	2.77e-06	20	48	3	17107998
Pubmed	NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.	NDST4 NDST3 NDST1	3.73e-06	22	48	3	19299468
Pubmed	Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.	KDM4A KDM4C	5.59e-06	3	48	2	27266524
Pubmed	Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.	NDST3 NDST1	5.59e-06	3	48	2	9915799
Pubmed	The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development.	KDM4A KDM4C	5.59e-06	3	48	2	19696013
Pubmed	Diversity within the JMJD2 histone demethylase family.	KDM4A KDM4C	5.59e-06	3	48	2	17207460
Pubmed	Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells.	KDM4A KDM4C	5.59e-06	3	48	2	17611647
Pubmed	The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.	KDM4A KDM4C	5.59e-06	3	48	2	31434704
Pubmed	Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.	LEPR LRRK2	5.59e-06	3	48	2	22357653
Pubmed	Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc.	KDM4A KDM4C	1.12e-05	4	48	2	33462212
Pubmed	The histone demethylase Kdm4 suppresses activation of hepatic stellate cell by inducing MiR-29 transcription.	KDM4A KDM4C	1.12e-05	4	48	2	31014673
Pubmed	Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation.	NDST3 NDST1	1.12e-05	4	48	2	29688404
Pubmed	Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses.	NDST3 NDST1	1.12e-05	4	48	2	16056228
Pubmed	Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells.	KDM4A KDM4C	1.12e-05	4	48	2	26120059
Pubmed	Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.	KDM4A KDM4C	1.12e-05	4	48	2	27257215
Pubmed	Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.	KDM4A KDM4C	1.86e-05	5	48	2	16738407
Pubmed	Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.	KDM4A KDM4C	1.86e-05	5	48	2	21914792
Pubmed	Identification and characterization of JMJD2 family genes in silico.	KDM4A KDM4C	2.79e-05	6	48	2	15138608
Pubmed	A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium.	BMPR2 ICOS	3.90e-05	7	48	2	10964520
Pubmed	Altered heparan sulfate structure in mice with deleted NDST3 gene function.	NDST3 NDST1	3.90e-05	7	48	2	18385133
Pubmed	Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.	KDM4A KDM4C	3.90e-05	7	48	2	21445275
Pubmed	Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis.	NEK1 LRRK2	8.33e-05	10	48	2	29891719
Pubmed	Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.	KDM4A KDM4C	1.02e-04	11	48	2	19144645
Pubmed	Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.	KDM4A KDM4C	1.68e-04	14	48	2	16603238
Pubmed	Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.	NDST4 NDST3 NDST1	1.95e-04	81	48	3	39217171
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	NDST1 BMPR2 ADAMTS6	3.63e-04	100	48	3	25807483
Pubmed	The transcription factor Maz is essential for normal eye development.	FZD4 ALDH1A1	3.85e-04	21	48	2	32571845
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM4A KDM4C	3.85e-04	21	48	2	27626377
Pubmed	Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.	KDM4A KDM4C	4.23e-04	22	48	2	28963472
Pubmed	GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.	THADA TRIM5	4.63e-04	23	48	2	23725790
Pubmed	Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.	NEK1 LRRK2	5.48e-04	25	48	2	24947832
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP34 NEMP1 KDM4A BRPF3 WDR37	7.98e-04	529	48	5	14621295
Pubmed	Genome-wide searching of rare genetic variants in WTCCC data.	NDST3 ZFAT	9.01e-04	32	48	2	20549515
Pubmed	Lem2 is essential for cardiac development by maintaining nuclear integrity.	ADAMTS6 SYNE2	9.01e-04	32	48	2	37067297
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM4A KDM4C	9.58e-04	33	48	2	26864203
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	BMPR2 GALNT7	1.14e-03	36	48	2	25615642
Pubmed	Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.	KDM4A KDM4C LEPR	1.16e-03	149	48	3	25231870
Pubmed	Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric mesenchyme by balancing SHH and BMP4 signaling.	BMPR2 ALDH1A1	1.20e-03	37	48	2	36094016
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	ALDH1A1 BMP2K	1.20e-03	37	48	2	22432025
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CD59 USP34 NEMP1 NDST1 BMPR2 THADA GALNT7	1.23e-03	1201	48	7	35696571
Pubmed	Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.	CD59 PATE4	1.27e-03	38	48	2	27098205
Interaction	NDST4 interactions	NDST4 NDST3 NDST1	6.60e-07	8	47	3	int:NDST4
Cytoband	4q26	NDST4 NDST3	9.85e-04	44	48	2	4q26
Cytoband	Ensembl 112 genes in cytogenetic band chr4q26	NDST4 NDST3	1.53e-03	55	48	2	chr4q26
Cytoband	17p13.2	ZNF232 SCIMP	1.53e-03	55	48	2	17p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q34	GALNT7 ASB5	1.88e-03	61	48	2	chr4q34
GeneFamily	Sulfotransferases, membrane bound	NDST4 NDST3 NDST1	5.84e-05	37	37	3	763
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM4A KDM4C	1.09e-03	24	37	2	485
GeneFamily	CD molecules\|Complement system\|LY6/PLAUR domain containing	CD59 PATE4	2.19e-03	34	37	2	1226
GeneFamily	Tudor domain containing	KDM4A KDM4C	2.59e-03	37	37	2	780
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	FZD4 CD59 ICOS LEPR	8.32e-03	394	37	4	471
Coexpression	KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3	FAM76B CD59 NDST1 BMPR2 THADA ADAMTS6 SEC14L2 SYNE2 CNIH1	1.92e-05	843	48	9	M2356
Coexpression	ZHENG_BOUND_BY_FOXP3	FAM76B THADA ICOS WDR37 ADAMTS6 TRIM5 SYNE2	3.22e-05	498	48	7	M1741
Coexpression	ZHENG_BOUND_BY_FOXP3	FAM76B THADA ICOS WDR37 ADAMTS6 TRIM5 SYNE2	3.60e-05	507	48	7	MM1030
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ERMAP RASGRP1 ELP2 ZFAT ICOS	9.13e-07	164	48	5	d6806deabf5f5c355934387be2baae125ac33fb8
ToppCell	COVID-19-lung-Capillary_1\|lung / Disease (COVID-19 only), tissue and cell type	FZD4 BMPR2 ADAMTS6 LEPR SYNE2	2.25e-06	197	48	5	7e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCell	(6)_Endothelial-E\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	FZD4 CD59 BMPR2 ADAMTS6 LEPR	2.30e-06	198	48	5	a5e1b321376caf262ea48904d31afd1b8e9d3be2
ToppCell	343B-Endothelial_cells-Endothelial-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	FZD4 CD59 BMPR2 ADAMTS6 LEPR	2.36e-06	199	48	5	bff61a784ef8bc040f5c7baabccaf7a7cddd5a31
ToppCell	343B-Endothelial_cells-Endothelial-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	FZD4 CD59 BMPR2 ADAMTS6 LEPR	2.36e-06	199	48	5	3cb1d9d9de64ed0a56c4f8d5e2fa02a13a73d8ac
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FZD4 RASGRP1 BRPF3 TRIM5	1.57e-05	140	48	4	276b3fa924176426efb31112ed4d355407f0b218
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NDST4 PLCZ1 ZAN	2.57e-05	53	48	3	5fa009c9f30c77de6cece40a47da46241f1de54c
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NDST4 PLCZ1 ZAN	2.57e-05	53	48	3	52a1f2a041e3ba2b11ed753f2f57b78e68b5cc0c
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASGRP1 ICOS ADAMTS6 ASB5	3.52e-05	172	48	4	1aecc98a3eadabae0f1f328091a9733d916017ec
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BRPF3 BMPR2 BMP2K LEPR	3.76e-05	175	48	4	1d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BRPF3 BMPR2 BMP2K LEPR	3.76e-05	175	48	4	427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-regulatory_T_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RASGRP1 THADA ICOS SYNE2	3.85e-05	176	48	4	856a8c4211ea33d926b18d8959a03909562aa563
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RASGRP1 ICOS ADAMTS6 SYNE2	4.02e-05	178	48	4	f94e306b9550f3d1b5de0bb806790c17823d439e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD59 RASGRP1 ICOS SYNE2	4.20e-05	180	48	4	6bb9f41c3a99d1bbe697f589fb2bcea9b7bfbeee
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASGRP1 THADA ICOS SLC25A40	4.48e-05	183	48	4	c9cb69377883d4579c608ec8b265153fe5290e67
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RASGRP1 BMPR2 SCIMP LRRK2	4.48e-05	183	48	4	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD59 RASGRP1 ICOS SYNE2	4.58e-05	184	48	4	08bff25390e3484b75c860738396a405141b69fd
ToppCell	IPF-Lymphoid-T_Regulatory\|IPF / Disease state, Lineage and Cell class	RASGRP1 THADA ICOS SYNE2	4.67e-05	185	48	4	221cbd09d94cc0947d0e3c1aa14716d17cb2068d
ToppCell	IPF-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	RASGRP1 THADA ICOS SYNE2	4.67e-05	185	48	4	77fbecdab10bacc005b1c7e22ca414cfecef13c1
ToppCell	COPD-Lymphoid-T_Regulatory\|COPD / Disease state, Lineage and Cell class	RASGRP1 THADA ICOS SYNE2	4.67e-05	185	48	4	846403edd4c8f646201d519055198fc38b7ffff9
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD59 BMPR2 LEPR LRRK2	4.67e-05	185	48	4	fa94c4a1660967f211ba095606cd0aa37d38e17a
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RASGRP1 ICOS ADAMTS6 SYNE2	4.67e-05	185	48	4	f1263899a2d41d182022dc4ca62cbae08a463c89
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RASGRP1 ICOS ADAMTS6 SYNE2	4.77e-05	186	48	4	bbcd9062c0f6f65ca6f3cb101b6fa72ddd1e14fe
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RASGRP1 CFAP54 EPHA7 LRRK2	4.77e-05	186	48	4	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP54 SYNE2 EPHA7 LRRK2	4.77e-05	186	48	4	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD59 BMPR2 LEPR LRRK2	4.87e-05	187	48	4	37d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NDST4 NDST3 TRAF5 ADAMTS6	4.87e-05	187	48	4	387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCell	3'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD59 BMPR2 LEPR LRRK2	4.87e-05	187	48	4	ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD59 RASGRP1 ICOS SYNE2	4.87e-05	187	48	4	9fdfca5b70f585843ef9d810154674a8e561e765
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD59 RASGRP1 ICOS SYNE2	4.87e-05	187	48	4	a525753a8a908ee1ef0b8f06e68855e4af27bf86
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NDST4 NDST3 TRAF5 ADAMTS6	4.98e-05	188	48	4	3004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCell	IPF-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	CD59 THADA ICOS CNIH1	5.08e-05	189	48	4	7a260485c2a7c743c14d048e5e480ae0a9b8e32c
ToppCell	NS-critical-d_0-4-Lymphoid-CTL\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RASGRP1 TRAF5 ICOS SYNE2	5.08e-05	189	48	4	fb7572fb4c7c43886d57a025decad076f32a14c4
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NDST4 NDST3 TRAF5 ADAMTS6	5.08e-05	189	48	4	0abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCell	normal_Pleural_Fluid-T/NK_cells-Treg\|normal_Pleural_Fluid / Location, Cell class and cell subclass	CD59 RASGRP1 ICOS SYNE2	5.18e-05	190	48	4	632b9541371483d25948b6f033863c49f38e3603
ToppCell	normal-na-Lymphocytic_T-T4_reg-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CD59 RASGRP1 ICOS SYNE2	5.18e-05	190	48	4	d8c1998eb02d5105598608d4733b63978ffa3eb2
ToppCell	metastatic_Lymph_Node-T/NK_cells-Treg\|metastatic_Lymph_Node / Location, Cell class and cell subclass	RASGRP1 THADA ICOS SYNE2	5.18e-05	190	48	4	0523f1039b39a45a23f2f4444e5b47ed581fc4bb
ToppCell	normal-na-Lymphocytic_T-T4_reg\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CD59 RASGRP1 ICOS SYNE2	5.18e-05	190	48	4	b8897c3e0fe8bb7efaf6a3787104d454d81a4c92
ToppCell	COPD-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	THADA ICOS SYNE2 CNIH1	5.29e-05	191	48	4	3ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCell	severe-Lymphocytic-CD4_T_cells_3\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CD59 RASGRP1 ICOS SYNE2	5.29e-05	191	48	4	afff6bfae9a2f1e17d2731315e7fe63c4601679f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP54 SYNE2 EPHA7 LRRK2	5.29e-05	191	48	4	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	Adult-Immune-T_lymphocyte-D175\|Adult / Lineage, Cell type, age group and donor	RASGRP1 TRAF5 ICOS SYNE2	5.29e-05	191	48	4	0b84fd1dc68146d9f72422b102744d2847f5ecb2
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD59 RASGRP1 ICOS SYNE2	5.40e-05	192	48	4	7a90ec9fc8f29216c4828e0cf5d040906456e53b
ToppCell	COVID-19_Severe-Lymphoid_T/NK-Treg\|COVID-19_Severe / Disease group, lineage and cell class	CD59 RASGRP1 ICOS SYNE2	5.40e-05	192	48	4	3fb4c148dadcf5e79094e55c6bb53ec7bf9d44c8
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CD59 RASGRP1 ICOS SYNE2	5.40e-05	192	48	4	d883b91bbab71673de4858346d3ab33e5fbbf842
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNMA1 TRAF5 ALDH1A1 ADAMTS6	5.51e-05	193	48	4	4aa976b596830b585e8d9c808d5072ed23d13a7c
ToppCell	metastatic_Lymph_Node-T/NK_cells-Treg\|T/NK_cells / Location, Cell class and cell subclass	CD59 THADA ICOS CNIH1	5.51e-05	193	48	4	bac302e69455aaaf1c18f3272bb213242664d747
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW12\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	ICOS SYNE2 EPHA7 CNIH1	5.51e-05	193	48	4	f62acf580ba642929f0f430dc4b3a9b6e828d7b0
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-T4_reg\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CD59 RASGRP1 ICOS SYNE2	5.51e-05	193	48	4	2a06bb3d6bbe544a26dc42d94a10f60acfd3600b
ToppCell	Control-Lymphoid_T/NK-Treg\|Control / Disease group, lineage and cell class	CD59 RASGRP1 ICOS SYNE2	5.51e-05	193	48	4	715f2bbee12a7952cba85d9cd8820411983ce790
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	RASGRP1 ICOS SEC14L2 SYNE2	5.51e-05	193	48	4	498d3a83bce6deff69aea71b18a43688e0a8ed7d
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-T4_reg-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CD59 RASGRP1 ICOS SYNE2	5.51e-05	193	48	4	b4f8afd871fdf9418b92ff419c8ba9739b6093ca
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-Tregs\|blood / Manually curated celltypes from each tissue	CD59 RASGRP1 ICOS SYNE2	5.51e-05	193	48	4	2ffe44edf2b02d11a7c10513692eb697a10f911e
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNMA1 TRAF5 ALDH1A1 ADAMTS6	5.51e-05	193	48	4	5578f7cb3ec68c9a38cc5304b618b81283024d5e
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FZD4 BMPR2 ADAMTS6 LEPR	5.51e-05	193	48	4	ad3f4fcc8e2816d696cbcde744dc16500e51ccac
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Treg\|T/NK_cells / Location, Cell class and cell subclass	CD59 THADA ICOS CNIH1	5.62e-05	194	48	4	e46963d5f156526342ebc0fb9e767d266e812c42
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RASGRP1 TRAF5 ICOS SYNE2	5.62e-05	194	48	4	3d6f2d190dd50804afea299957cc44c2bb756134
ToppCell	Healthy/Control-CD4+_Tcm\|World / Disease group and Cell class	RASGRP1 ICOS SEC14L2 SYNE2	5.62e-05	194	48	4	cbdd1786305108cbeddea07a21120067d78c59a0
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNMA1 TRAF5 ALDH1A1 ADAMTS6	5.62e-05	194	48	4	12a2c60303607b8b5812405ad216d0612c56c64b
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CD59 RASGRP1 ICOS SYNE2	5.62e-05	194	48	4	2faf49d85d09932c9c20d9f675c8093ad802fae5
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD59 RASGRP1 ICOS SYNE2	5.62e-05	194	48	4	fd3d5ac94de3db7136684c86f8589631ad87e6d8
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNMA1 TRAF5 ALDH1A1 ADAMTS6	5.62e-05	194	48	4	15060cc25baf49dd04d9c20499e28718610ef754
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FZD4 BMPR2 LEPR SMIM2	5.62e-05	194	48	4	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FZD4 BMPR2 LEPR SMIM2	5.62e-05	194	48	4	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NDST4 NDST3 TRAF5 ADAMTS6	5.62e-05	194	48	4	67f5e2f05a8de2213ab80d5ea16fdee121684633
ToppCell	COVID-19-lung-CD4+_T_cells_metabolically_active\|lung / Disease (COVID-19 only), tissue and cell type	RASGRP1 TRAF5 ICOS SYNE2	5.62e-05	194	48	4	2a144a1c2d537c8a59aa419206ddd96c23f0aeab
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-Memory_B\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRAF5 SCIMP ADAMTS6 LRRK2	5.73e-05	195	48	4	f43dacc972dc4df574c4639952d3be9fc4201d33
ToppCell	tumor_Lung-T/NK_cells-Treg\|T/NK_cells / Location, Cell class and cell subclass	CD59 THADA ICOS CNIH1	5.73e-05	195	48	4	dd112ef3f8bd0790719827b6bb120918687afdff
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNMA1 TRAF5 ALDH1A1 ADAMTS6	5.73e-05	195	48	4	bd7526dd80a60ff7bc866e4f5a0e8acdbc10d191
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNMA1 TRAF5 ALDH1A1 ADAMTS6	5.73e-05	195	48	4	8a04f0e92d10a368ccda5f566ae67ef51f1d34a9
ToppCell	367C-Endothelial_cells-Endothelial-E-\|367C / Donor, Lineage, Cell class and subclass (all cells)	FZD4 CD59 BMPR2 ADAMTS6	5.73e-05	195	48	4	65fc50e3818e902028fc4226070fa57609c66b9c
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|World / disease group, cell group and cell class (v2)	RASGRP1 ICOS SEC14L2 SYNE2	5.73e-05	195	48	4	a72bb5b1b15dd1ab70ced5622d94499caff8bb6b
ToppCell	367C-Endothelial_cells-Endothelial-E\|367C / Donor, Lineage, Cell class and subclass (all cells)	FZD4 CD59 BMPR2 ADAMTS6	5.73e-05	195	48	4	3b79e6bb525b17192ecec9e1227a29c419968144
ToppCell	BLOOD--(1)_Activated_T_cells\| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CD59 RASGRP1 ICOS SYNE2	5.73e-05	195	48	4	45515d5da8a8c8242eb70a1bea24fe44eca5407b
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	CD59 ALDH1A1 ICOS SCIMP	5.85e-05	196	48	4	fe90501010128b72e6711c567cb04b012f1520a4
ToppCell	Severe-Lymphoid-T-CD8_T\|Severe / Condition, Lineage, Cell class and cell subclass	RASGRP1 ICOS ADAMTS6 SYNE2	5.97e-05	197	48	4	00d884ec591f63a345d7fd0a6b368f9da4b4c6ce
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FZD4 CD59 BMPR2 LEPR	5.97e-05	197	48	4	0542badae77d2f606c13cfaf361319495c354351
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FZD4 CD59 BMPR2 SYNE2	5.97e-05	197	48	4	e8e879b7634a29569061d3515d180784094a31e7
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD59 THADA ICOS SYNE2	5.97e-05	197	48	4	7c9df6025b9d168bd6d041c6cff1e87e08b11847
ToppCell	B_cells-Memory_B_cells\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	TRAF5 SCIMP BMP2K LRRK2	5.97e-05	197	48	4	cdd1dbdaf257b0864c6dc8c1cbed6e9b68e114b7
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FZD4 CD59 BMPR2 LEPR	5.97e-05	197	48	4	7a1a3839b2c965136663241b0d4e96c64cfb656a
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNMA1 TRAF5 ALDH1A1 ADAMTS6	5.97e-05	197	48	4	5a63c2b824c7d0dbbc706e408459c9b9fe65daaa
ToppCell	control-Treg\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CD59 RASGRP1 ICOS SYNE2	5.97e-05	197	48	4	a80674a0b996aa57d52bfff7264c57caf4c31cc6
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FZD4 CD59 BMPR2 LEPR	5.97e-05	197	48	4	a6a64581699cfcb9607b288976fa3b09648725b7
ToppCell	Severe_COVID-19-T/NK-CD4+_T_2\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	RASGRP1 TRAF5 ICOS SYNE2	6.08e-05	198	48	4	c8c9343c19198b6534f8f07e74405e29b3a164bf
ToppCell	ASK452-Endothelial-Endothelium\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	CD59 BMPR2 LEPR SYNE2	6.08e-05	198	48	4	e282769f5fa1765bcce79a0ed9d761bf2e14b012
ToppCell	Sepsis-URO-Lymphocyte-T/NK-CD4+_CTL\|URO / Disease, condition lineage and cell class	RASGRP1 ICOS ADAMTS6 SYNE2	6.08e-05	198	48	4	c53405a8d082fbd10131a6ec88b69fdd835f2925
ToppCell	343B-Endothelial_cells\|343B / Donor, Lineage, Cell class and subclass (all cells)	FZD4 CD59 BMPR2 LEPR	6.08e-05	198	48	4	fab32347580c7a81ef1fe4fe7b325d9105a947d9
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FZD4 CD59 BMPR2 LEPR	6.08e-05	198	48	4	5b86dc00acf8ac2ede008f5d79c09996485bf250
ToppCell	severe-Treg\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CD59 RASGRP1 ICOS SYNE2	6.08e-05	198	48	4	377980b9f7d02818e1d145e6884604f8bfacc4f2
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FZD4 CD59 BMPR2 LEPR	6.08e-05	198	48	4	3ae1e2b4ca77b94eaa24a8c990780aff47dface6
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FZD4 CD59 BMPR2 LEPR	6.08e-05	198	48	4	13203249e5743ba2699871c184d141207e550a86
ToppCell	Transplant_Alveoli_and_parenchyma-Endothelial-Endothelial\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	FZD4 BMPR2 LEPR SYNE2	6.08e-05	198	48	4	531b0f88c95f813e3914c96749f591e80ca321d0
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FZD4 CD59 BMPR2 LEPR	6.08e-05	198	48	4	fb70a649e4e2edb32967328c1085dc5999c29a33
ToppCell	severe-Treg\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CD59 RASGRP1 ICOS SYNE2	6.08e-05	198	48	4	4935b40fc848037a06055f30d90bde940b9d5321
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_Exhausted\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RASGRP1 TRAF5 ICOS SYNE2	6.08e-05	198	48	4	a5f5c0b42ae43ba48a7e4f06c4ad179b2244d941
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_2-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RASGRP1 TRAF5 ICOS SYNE2	6.08e-05	198	48	4	93773b1abbf46b39e320d628077bf94958b872a4
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FZD4 CD59 BMPR2 LEPR	6.08e-05	198	48	4	71ee440b1ac566db63d0b415c50a0ad064d14f15
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_2\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	RASGRP1 TRAF5 ICOS SYNE2	6.08e-05	198	48	4	812ffe7369bf83ae5071970934c8831611db9557
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_Exhausted-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RASGRP1 TRAF5 ICOS SYNE2	6.08e-05	198	48	4	bb99db3e04d547248ea66953c2f8dd55c530461c
Computational	Neighborhood of BMPR2	UGT2B4 BMPR2 EPHA7	4.62e-04	53	31	3	MORF_BMPR2
Computational	Neighborhood of EPHA7	UGT2B4 BMPR2 SEC14L2 EPHA7	6.42e-04	139	31	4	MORF_EPHA7
Computational	Genes in the cancer module 119.	CD59 USP34 GMCL1 SYNE2	7.15e-04	143	31	4	MODULE_119
Drug	Ethosuximide [77-67-8]; Down 200; 28.4uM; PC3; HT_HG-U133A	USP34 BMPR2 SLC25A40 BMP2K RNF146 SYNE2	3.53e-06	197	48	6	2116_DN
Disease	quinate measurement	KDM4C LEPR LRRK2	1.70e-06	15	47	3	EFO_0021167
Disease	intellectual disability (implicated_via_orthology)	NDST4 NDST3 NDST1 ELP2	6.32e-06	75	47	4	DOID:1059 (implicated_via_orthology)
Disease	azoospermia (implicated_via_orthology)	NDST4 NDST3 NDST1	1.08e-05	27	47	3	DOID:14227 (implicated_via_orthology)
Disease	sex interaction measurement, Crohn's disease	USP34 RASGRP1 LRRK2	2.83e-05	37	47	3	EFO_0000384, EFO_0008343
Disease	Pulmonary Hypertension	KCNMA1 BMPR2 LEPR	3.59e-05	40	47	3	C0020542
Disease	Obesity, Morbid	KCNMA1 LEPR	5.19e-05	7	47	2	C0028756
Disease	Papillary Renal Cell Carcinoma	KCNMA1 ALDH1A1 SYNE2 LRRK2	5.21e-05	128	47	4	C1306837
Disease	Renal Cell Carcinoma	KCNMA1 ALDH1A1 SYNE2 LRRK2	5.21e-05	128	47	4	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	KCNMA1 ALDH1A1 SYNE2 LRRK2	5.21e-05	128	47	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	KCNMA1 ALDH1A1 SYNE2 LRRK2	5.21e-05	128	47	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	KCNMA1 ALDH1A1 SYNE2 LRRK2	5.21e-05	128	47	4	C1266044
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	KCNMA1 ALDH1A1 SYNE2 LRRK2	9.17e-05	148	47	4	C0279702
Disease	autism spectrum disorder (implicated_via_orthology)	NDST4 NDST3 NDST1 ELP2	1.02e-04	152	47	4	DOID:0060041 (implicated_via_orthology)
Disease	alopecia areata (is_marker_for)	KDM4A KDM4C	1.11e-04	10	47	2	DOID:986 (is_marker_for)
Disease	rheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement	FAM76B RASGRP1 ICOS	1.41e-04	63	47	3	EFO_0000685, EFO_0007791, EFO_0009459
Disease	autoimmune disease	FAM76B RASGRP1 ICOS SEC14L2	1.67e-04	173	47	4	EFO_0005140
Disease	atrial fibrillation	FAM76B USP34 GMCL1 ZFAT SYNE2	3.04e-04	371	47	5	EFO_0000275
Disease	sphingomyelin 14:0 measurement	THADA SYNE2	3.33e-04	17	47	2	EFO_0010390
Disease	posterior cingulate cortex volume measurement	NDST4 KDM4C	3.33e-04	17	47	2	EFO_0010324
Disease	age at menarche	NDST4 USP34 NEMP1 KDM4A KDM4C LEPR	3.46e-04	594	47	6	EFO_0004703
Disease	autoimmune thyroid disease, Hashimoto's thyroiditis, Graves disease	FAM76B ICOS	3.74e-04	18	47	2	EFO_0003779, EFO_0004237, EFO_0006812
Disease	alpha-tocopherol measurement	KDM4C SEC14L2	4.63e-04	20	47	2	EFO_0007898
Disease	Immunologic Deficiency Syndromes	RASGRP1 LEPR	6.15e-04	23	47	2	C0021051
Disease	stomach carcinoma (is_marker_for)	KDM4A KDM4C	6.70e-04	24	47	2	DOID:5517 (is_marker_for)
Disease	Autosomal Dominant Parkinsonism	ALDH1A1 LRRK2	9.14e-04	28	47	2	C0752098
Disease	Autosomal Dominant Juvenile Parkinson Disease	ALDH1A1 LRRK2	9.14e-04	28	47	2	C0752097
Disease	Parkinsonism, Experimental	ALDH1A1 LRRK2	9.14e-04	28	47	2	C0752101
Disease	Autosomal Recessive Parkinsonism	ALDH1A1 LRRK2	9.14e-04	28	47	2	C0752100
Disease	Familial Juvenile Parkinsonism	ALDH1A1 LRRK2	9.14e-04	28	47	2	C0752104
Disease	Ramsay Hunt Paralysis Syndrome	ALDH1A1 LRRK2	9.14e-04	28	47	2	C0242423
Disease	PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	ALDH1A1 LRRK2	9.14e-04	28	47	2	C1868675
Disease	Parkinsonism, Juvenile	ALDH1A1 LRRK2	1.05e-03	30	47	2	C0752105
Disease	Parkinsonian Disorders	ALDH1A1 LRRK2	1.05e-03	30	47	2	C0242422
Disease	obsolete_red blood cell distribution width	ERMAP FAM76B GMCL1 BMPR2 BMP2K TRIM5 RNF146 SYNE2	1.19e-03	1347	47	8	EFO_0005192

Protein segments in the cluster

Peptide	Gene	Start	Entry
VKVSWYCILGCKAEG	CFAP54	931	Q96N23
FLWGVIKQGYRCKDC	RASGRP1	561	O95267
WKLTCYICKQKGLGA	BRPF3	321	Q9ULD4
CIKTLRYCAGWADKI	ALDH1A1	126	P00352
CLITKAGLQVYNKCW	CD59	51	P13987
KADIWALGCLLYKLC	BMP2K	246	Q9NSY1
CKYGEVCRELWCLSK	ADAMTS6	501	Q9UKP5
GTYGLDSVKKKCLEW	GMCL1	221	Q96IK5
GFWCQLLEEGKTKCL	NDST3	806	O95803
MGLKCNTCIYTEGWK	PATE4	21	P0C8F1
LKYLWTVCCHCGGKT	KCNMA1	111	Q12791
IWALGCVLYELCTLK	NEK1	186	Q96PY6
WLYITCRKVCKGAEK	NEMP1	321	O14524
CFWKTEVLVKACPGG	GP2	146	P55259
FWCQLLEGGKTKCLG	NDST1	816	P52848
WIEYGKQAVLCSCRK	KDM4A	296	O75164
VRWIDYGKVAKLCTC	KDM4C	296	Q9H3R0
CGEGETLLKKWALYS	LRRK2	1801	Q5S007
KVDGKLLCWLCTLSY	FAM76B	121	Q5HYJ3
CWLKGDLKLFICYVE	LEPR	131	P48357
LWLCLYAKLGELCVD	MON2	1021	Q7Z3U7
FWCQLLEGGKTKCLG	NDST4	806	Q9H3R1
WLVPIGKCICKAGYQ	EPHA7	256	Q15375
LGCILICWLTKKKYS	ICOS	156	Q9Y6W8
YIWVKRSLNCVLKCG	FZD4	191	Q9ULV1
YKIWQCGGKLLFVPC	GALNT7	421	Q86SF2
CYGLWEKSKGDINLV	BMPR2	66	Q13873
CIWKLLYAGADVQKG	ASB5	216	Q8WWX0
AVGLECGKICLYTWK	ELP2	741	Q6IA86
CGKICLYTWKKTDQV	ELP2	746	Q6IA86
IIYDCEGLGLKHLWK	SEC14L2	151	O76054
EVYVGDKTKWILGVC	ERMAP	296	Q96PL5
LVRKTWKCGYVECSA	RASL10B	146	Q96S79
RLEWHIKGKYTCLGC	THADA	446	Q6YHU6
SVGLGLILYCVCKWQ	SCIMP	31	Q6UWF3
GIGLNEKFLYCCEKW	SYNE2	5591	Q8WXH0
LCVCEEGGNKLWYKK	SLC25A40	66	Q8TBP6
WGYVSALVKGCRCLE	PLCZ1	186	Q86YW0
FCYLCVKGASWLGKR	RNF146	56	Q9NTX7
LLEGTCYNGKLIWKV	TRAF5	396	O00463
ILAYCQKEGWCKLAF	CNIH1	111	O95406
CDTYIVLAWISKIKG	SMIM2	36	Q9BVW6
KLLLFCQEDGKVICW	TRIM5	101	Q9C035
LKCPVCSFVYGTKWE	ZFAT	1041	Q9P243
CLFCVWKFVRTGKKG	UGT2B4	511	P06133
ALLWSIETGKCLVKY	WDR37	181	Q9Y2I8
KECGKAYGWCSELIR	ZNF232	391	Q9UNY5
ILKPGCKEYFWLLCK	USP34	1726	Q70CQ2
VGERWYKPGCKELCV	ZAN	1491	Q9Y493