Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	mucus layer	MUC2 MUC5AC	7.05e-05	3	102	2	GO:0070701
Domain	WxxW_domain	MUC2 MUC5AC	4.03e-04	6	98	2	IPR025155
Domain	Mucin2_WxxW	MUC2 MUC5AC	4.03e-04	6	98	2	PF13330
Domain	EGF	VASN STAB1 THBS4 LTBP2 NOTCH2	5.31e-04	126	98	5	PF00008
Domain	Notch_dom	PAPPA NOTCH2	5.63e-04	7	98	2	IPR000800
Domain	Notch	PAPPA NOTCH2	5.63e-04	7	98	2	PF00066
Domain	NL	PAPPA NOTCH2	5.63e-04	7	98	2	SM00004
Domain	PTB	SH2D5 TBC1D1 MAPK8IP2	1.20e-03	40	98	3	SM00462
Domain	PTB/PI_dom	SH2D5 TBC1D1 MAPK8IP2	1.29e-03	41	98	3	IPR006020
Domain	EGF_3	ADAM19 VASN STAB1 THBS4 LTBP2 NOTCH2	1.50e-03	235	98	6	PS50026
Domain	TIL	MUC2 MUC5AC	1.74e-03	12	98	2	PF01826
Domain	C8	MUC2 MUC5AC	1.74e-03	12	98	2	PF08742
Domain	EGF-like_dom	ADAM19 VASN STAB1 THBS4 LTBP2 NOTCH2	2.00e-03	249	98	6	IPR000742
Domain	Unchr_dom_Cys-rich	MUC2 MUC5AC	2.05e-03	13	98	2	IPR014853
Domain	C8	MUC2 MUC5AC	2.05e-03	13	98	2	SM00832
Domain	EGF_1	ADAM19 VASN STAB1 THBS4 LTBP2 NOTCH2	2.26e-03	255	98	6	PS00022
Domain	TIL_dom	MUC2 MUC5AC	2.38e-03	14	98	2	IPR002919
Domain	EGF-like_CS	ADAM19 VASN STAB1 THBS4 LTBP2 NOTCH2	2.53e-03	261	98	6	IPR013032
Domain	zf-RING_2	RNF223 RNF43 RNF111	2.57e-03	52	98	3	PF13639
Domain	EGF_2	ADAM19 VASN STAB1 THBS4 LTBP2 NOTCH2	2.73e-03	265	98	6	PS01186
Domain	VWD	MUC2 MUC5AC	3.12e-03	16	98	2	SM00216
Domain	VWF_type-D	MUC2 MUC5AC	3.12e-03	16	98	2	IPR001846
Domain	VWFD	MUC2 MUC5AC	3.12e-03	16	98	2	PS51233
Domain	VWD	MUC2 MUC5AC	3.12e-03	16	98	2	PF00094
Domain	EGF_extracell	ADAM19 STAB1 LTBP2	3.86e-03	60	98	3	IPR013111
Domain	EGF_2	ADAM19 STAB1 LTBP2	3.86e-03	60	98	3	PF07974
Domain	EGF_CA	STAB1 THBS4 LTBP2 NOTCH2	3.90e-03	122	98	4	SM00179
Domain	CTCK_1	MUC2 MUC5AC	3.95e-03	18	98	2	PS01185
Domain	EGF-like_Ca-bd_dom	STAB1 THBS4 LTBP2 NOTCH2	4.14e-03	124	98	4	IPR001881
Domain	VWC_out	MUC2 MUC5AC	4.40e-03	19	98	2	SM00215
Domain	ZF_RING_2	RNF223 RNF43 TRIM7 KMT2C LONRF2 RNF111	4.85e-03	298	98	6	PS50089
Domain	RING	RNF223 RNF43 TRIM7 KMT2C LONRF2 RNF111	5.42e-03	305	98	6	SM00184
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA6C RNF223 ZNF628 POLRMT PRAG1 ZBTB42 RNF43 SBNO2 TRIM7 JAK3 KMT2C TULP4 NAPRT GPC2 NOTCH2 CBX2 BAHCC1 HR	5.61e-09	1105	105	18	35748872
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	ACD POLRMT ARHGEF17 BPTF KMT2C UNG	1.73e-06	119	105	6	23508102
Pubmed	Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.	MUC2 MUC5AC	9.03e-06	2	105	2	17203232
Pubmed	Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.	MUC2 MUC5AC	9.03e-06	2	105	2	12527922
Pubmed	Mucolytic activity of bacterial and human chitinases.	MUC2 MUC5AC	9.03e-06	2	105	2	17321686
Pubmed	Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma.	MUC2 MUC5AC	9.03e-06	2	105	2	20731025
Pubmed	In vivo glycosylation of mucin tandem repeats.	MUC2 MUC5AC	9.03e-06	2	105	2	11445551
Pubmed	Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins.	MUC2 MUC5AC	9.03e-06	2	105	2	23832517
Pubmed	Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution.	MUC2 MUC5AC	9.03e-06	2	105	2	23832516
Pubmed	MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB.	MYOD1 PPARGC1B	9.03e-06	2	105	2	27705798
Pubmed	Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma.	MUC2 MUC5AC	9.03e-06	2	105	2	14594655
Pubmed	The expression and interaction of hereditary factors producing hypotrichosis in the mouse; histology and experimental results.	HOXC13 HR	9.03e-06	2	105	2	21020475
Pubmed	Abnormal subcellular distribution of mature MUC2 and de novo MUC5AC mucins in adenomas of the rectum: immunohistochemical detection using non-VNTR antibodies to MUC2 and MUC5AC peptide.	MUC2 MUC5AC	9.03e-06	2	105	2	12820724
Pubmed	SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.	BACH1 FBXL17 NOTCH2	1.76e-05	17	105	3	27234298
Pubmed	Differences in the expression of mucins in various forms of cystitis glandularis.	MUC2 MUC5AC	2.70e-05	3	105	2	17659847
Pubmed	Biophysical characterization of the interaction between FAAP20-UBZ4 domain and Rev1-BRCT domain.	FAAP20 REV1	2.70e-05	3	105	2	26318859
Pubmed	Cadherin-catenin adhesion system and mucin expression: a comparison between young and older patients with gastric carcinoma.	MUC2 MUC5AC	2.70e-05	3	105	2	18825309
Pubmed	Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia.	MUC2 MUC5AC	2.70e-05	3	105	2	18300795
Pubmed	Gene expression profiling of colorectal mucinous adenocarcinomas.	MUC2 MUC5AC	2.70e-05	3	105	2	20485009
Pubmed	Expression of aberrant mucins in lobular carcinoma with histiocytoid feature of the breast.	MUC2 MUC5AC	2.70e-05	3	105	2	17333267
Pubmed	Clinicopathological and prognostic significance of MUC-2, MUC-4 and MUC-5AC expression in japanese gastric carcinomas.	MUC2 MUC5AC	2.70e-05	3	105	2	23464473
Pubmed	Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.	UNG REV1	2.70e-05	3	105	2	23140944
Pubmed	Meconium ileus in cystic fibrosis is not linked to central repetitive region length variation in MUC1, MUC2, and MUC5AC.	MUC2 MUC5AC	2.70e-05	3	105	2	24920497
Pubmed	Mucin gene polymorphisms in otitis media patients.	MUC2 MUC5AC	2.70e-05	3	105	2	19718741
Pubmed	Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas.	MUC2 MUC5AC	5.40e-05	4	105	2	33154304
Pubmed	Gastric mucin expression in first-degree relatives of gastric cancer patients.	MUC2 MUC5AC	5.40e-05	4	105	2	24901817
Pubmed	Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.	MUC2 MUC5AC	5.40e-05	4	105	2	25638393
Pubmed	Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS).	MUC2 MUC5AC	5.40e-05	4	105	2	36367122
Pubmed	Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.	MUC2 MUC5AC	5.40e-05	4	105	2	17471237
Pubmed	Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.	MUC2 MUC5AC	5.40e-05	4	105	2	22269464
Pubmed	The mouse secreted gel-forming mucin gene cluster.	MUC2 MUC5AC	5.40e-05	4	105	2	14984930
Pubmed	Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.	MUC2 MUC5AC	5.40e-05	4	105	2	22691042
Pubmed	Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.	MUC2 MUC5AC	5.40e-05	4	105	2	29869461
Pubmed	[Expression and clinical significance of Mucin and E-cadherin in colorectal tumors].	MUC2 MUC5AC	5.40e-05	4	105	2	17991319
Pubmed	Mucins in neoplastic spectrum of colorectal polyps: can they provide predictions?	MUC2 MUC5AC	5.40e-05	4	105	2	20929551
Pubmed	Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.	SGPP1 MUC2	5.40e-05	4	105	2	25166914
Pubmed	Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells.	MUC2 MUC5AC	5.40e-05	4	105	2	12391274
Pubmed	Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.	MUC2 MUC5AC	5.40e-05	4	105	2	23807779
Pubmed	MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance.	MUC2 MUC5AC	5.40e-05	4	105	2	27298226
Pubmed	PGE(2) induces MUC2 and MUC5AC expression in human intrahepatic biliary epithelial cells via EP4/p38MAPK activation.	MUC2 MUC5AC	5.40e-05	4	105	2	23619266
Pubmed	Mucin expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus.	MUC2 MUC5AC	5.40e-05	4	105	2	17401217
Pubmed	Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.	MUC2 MUC5AC	5.40e-05	4	105	2	12676567
Pubmed	Expression profile of mucins (MUC1, MUC2, MUC5AC, and MUC6) in ovarian mucinous tumours: changes in expression from benign to malignant tumours.	MUC2 MUC5AC	5.40e-05	4	105	2	25298197
Pubmed	Polymorphism of human mucin genes in chest disease: possible significance of MUC2.	MUC2 MUC5AC	8.97e-05	5	105	2	11062147
Pubmed	Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families.	LOX ADAMTSL4	8.97e-05	5	105	2	29758265
Pubmed	Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14.	MUC2 MUC5AC	8.97e-05	5	105	2	12507512
Pubmed	Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.	MUC2 MUC5AC	8.97e-05	5	105	2	12135769
Pubmed	pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins.	MUC2 MUC5AC	8.97e-05	5	105	2	10611155
Pubmed	Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett Esophagus?	MUC2 MUC5AC	8.97e-05	5	105	2	22261707
Pubmed	Differential expression of MUC genes in endometrial and cervical tissues and tumors.	MUC2 MUC5AC	8.97e-05	5	105	2	16188033
Pubmed	MUC1, MUC2, MUC4, MUC5AC and MUC6 expression in the progression of prostate cancer.	MUC2 MUC5AC	8.97e-05	5	105	2	16475027
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	ACD PRR30 IRF3 GLI4 CCDC120 ADAMTSL4 CBX2	1.23e-04	364	105	7	31391242
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC2 MUC5AC	1.34e-04	6	105	2	19110483
Pubmed	Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum.	MUC2 MUC5AC	1.34e-04	6	105	2	16142311
Pubmed	Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis.	MYOD1 THBS4	1.34e-04	6	105	2	9382869
Pubmed	Biosynthesis of gastrokine-2 in the human gastric mucosa: restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucins.	MUC2 MUC5AC	1.34e-04	6	105	2	17982272
Pubmed	Regulation of Rev1 by the Fanconi anemia core complex.	FAAP20 REV1	1.34e-04	6	105	2	22266823
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	ADAM19 THBS4 LOX LTBP2 MUC2	1.58e-04	167	105	5	22159717
Pubmed	TRIM7 inhibits encephalomyocarditis virus replication by activating interferon-β signaling pathway.	IRF3 TRIM7	1.88e-04	7	105	2	37023504
Pubmed	USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling.	RNF43 USP42	1.88e-04	7	105	2	33786993
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	BPTF KMT2C	2.50e-04	8	105	2	21447625
Pubmed	Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search.	SIMC1 RNF111	2.50e-04	8	105	2	23086935
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	MUC2 MUC5AC NOTCH2	2.62e-04	41	105	3	22675208
Pubmed	Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion.	MYOD1 LOX	3.21e-04	9	105	2	26954549
Pubmed	Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen.	HOXC13 HR	4.00e-04	10	105	2	9328433
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	EZH1 KMT2C HR	4.45e-04	49	105	3	34368113
Pubmed	Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.	FOXD2 FOXI1	4.88e-04	11	105	2	7683413
Pubmed	An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.	DDR1 CDK7	5.84e-04	12	105	2	1281307
Pubmed	Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country.	JAK3 UNG	6.89e-04	13	105	2	19859091
Pubmed	Conditional stabilization of beta-catenin expands the pool of lung stem cells.	MUC2 MUC5AC	6.89e-04	13	105	2	18356571
Pubmed	Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome.	MYOD1 NOTCH2	6.89e-04	13	105	2	9811581
Pubmed	VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability.	IRF3 STAB1	8.02e-04	14	105	2	25732088
Pubmed	Cilia-dependent GLI processing in neural crest cells is required for tongue development.	FOXD2 MYOD1	8.02e-04	14	105	2	28286175
Pubmed	Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.	MYOD1 NOTCH2	9.24e-04	15	105	2	17194759
Pubmed	HIV-1 reverse transcription.	POLR2M UNG	9.24e-04	15	105	2	23028129
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	DDR1 PRAG1 TRIM7 HERC4 RNF111 CDK7	9.51e-04	372	105	6	22939624
Pubmed	IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.	MYOD1 PPARGC1B	1.19e-03	17	105	2	22351927
Pubmed	Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.	EZH1 CBX2	1.19e-03	17	105	2	12589020
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC2 MUC5AC	1.34e-03	18	105	2	18834073
Pubmed	Mesenchymal-epithelial interaction regulates gastrointestinal tract development in mouse embryos.	LOX MUC2	1.34e-03	18	105	2	35830795
Pubmed	Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.	BACH1 FBXL17	1.34e-03	18	105	2	31257023
Pubmed	Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.	MYOD1 EZH1	1.34e-03	18	105	2	19303854
Pubmed	Muscle composition is regulated by a Lox-TGFβ feedback loop.	MYOD1 LOX	1.49e-03	19	105	2	25715398
Pubmed	Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway.	MUC5AC NOTCH2	1.49e-03	19	105	2	27122169
Pubmed	Transcription factor TFIIH components enhance the GR coactivator activity but not the cell cycle-arresting activity of the human immunodeficiency virus type-1 protein Vpr.	POLR2M CDK7	1.49e-03	19	105	2	12379213
Pubmed	Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.	NOTCH2 FOXI1	1.83e-03	21	105	2	19855135
Pubmed	E3 ubiquitin ligase FBXW7 balances airway cell fates.	MUC5AC NOTCH2	2.00e-03	22	105	2	34998785
Pubmed	The role of Irf6 in tooth epithelial invagination.	IRF3 NOTCH2	2.00e-03	22	105	2	22366192
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	INPP5K PRSS56 POLRMT EZH1 NCKAP5L RNF43 BPTF ZNF469 NOTCH2 BAHCC1	2.05e-03	1116	105	10	31753913
Pubmed	Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.	STAB1 HOXC13	2.39e-03	24	105	2	20935629
Pubmed	Dimerization quality control ensures neuronal development and survival.	BACH1 FBXL17	2.39e-03	24	105	2	30190310
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	TROAP LOX CCDC120 LONRF2 NOTCH2	2.44e-03	307	105	5	37499664
Pubmed	Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis.	MYOD1 GPC2	2.59e-03	25	105	2	26393505
Pubmed	Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.	MUC2 MUC5AC	2.59e-03	25	105	2	34391772
Pubmed	A quantitative protein interaction network for the ErbB receptors using protein microarrays.	SH2D5 JAK3 MAPK8IP2	2.60e-03	90	105	3	16273093
Pubmed	Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors.	MUC5AC NOTCH2	3.02e-03	27	105	2	32878924
Pubmed	Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.	MUC5AC NOTCH2	3.02e-03	27	105	2	21791528
Pubmed	Excess neuropeptides in lung signal through endothelial cells to impair gas exchange.	MUC5AC NOTCH2	3.02e-03	27	105	2	35303432
Interaction	ZKSCAN2 interactions	GLI4 LTBP2 NOTCH2	9.45e-06	9	99	3	int:ZKSCAN2
Coexpression	GSE22601_DOUBLE_POSITIVE_VS_CD8_SINGLE_POSITIVE_THYMOCYTE_UP	EZH1 ORAI2 NFKBIE PNRC1 ADAMTSL4 FAM8A1 RNF111	1.45e-05	200	103	7	M6253
Coexpression	GSE15324_NAIVE_VS_ACTIVATED_CD8_TCELL_UP	OCEL1 ZNF628 SIK1 ZBTB42 RUSC2 KMT2C PPARGC1B	1.45e-05	200	103	7	M3523
ToppCell	356C-Myeloid-Dendritic-pDC\|356C / Donor, Lineage, Cell class and subclass (all cells)	ADAM19 RPS6KA4 ABHD12B SIK1 GPC2 LONRF2	1.81e-06	156	104	6	d9d87368e43b24952e70f31f38425e15b716ff5b
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RPS6KA4 TROAP STAB1 GLI4 KLHDC7A LONRF2	2.42e-06	164	104	6	4307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RPS6KA4 TROAP STAB1 GLI4 KLHDC7A LONRF2	2.42e-06	164	104	6	1d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	THBS4 TBC1D1 SIMC1 SCNN1G LTBP2 FOXI1	2.50e-06	165	104	6	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	THBS4 TBC1D1 SIMC1 SCNN1G LTBP2 FOXI1	2.78e-06	168	104	6	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	COVID-19-Epithelial-Ionocytes\|Epithelial / Condition, Lineage and Cell class	PRAG1 TBC1D1 SCNN1G LTBP2 GPC2 FOXI1	4.27e-06	181	104	6	4a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PFKFB3 GSR SGPP1 SCNN1G PAPPA REPS2	4.27e-06	181	104	6	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DDR1 VASN PFKFB3 SGPP1 SCNN1G PAPPA	5.81e-06	191	104	6	7235a4d1601c88a2c8af571a2c04ab56d32f1b9a
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DDR1 CD177 PRSS22 MS4A15 SCNN1G MUC5AC	6.54e-06	195	104	6	b9e8f405f6d837bb39b615836d3e2df349737c0e
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DDR1 PFKFB3 SGPP1 SCNN1G PAPPA FOXI1	6.54e-06	195	104	6	0ac7762197cdd8d643f87148573a8df6e936c1b0
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DDR1 VASN PRSS22 PFKFB3 SGPP1 SCNN1G	7.35e-06	199	104	6	a4ebb0598e9a0c9f6e39a0db6d0623654c2a7d88
ToppCell	Biopsy_Other_PF-Immune-Monocytes\|Biopsy_Other_PF / Sample group, Lineage and Cell type	BACH1 PFKFB3 STAB1 JAK3 TNFRSF8 PNRC1	7.56e-06	200	104	6	83bca55d48aae8885deb83e15b2684910e4c3358
ToppCell	P07-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RNF43 TRIM7 NAPRT CRACDL LONRF2	2.99e-05	153	104	5	5501095bcf73080872ae01128f21399f9cfc5dd1
ToppCell	10x5'-bone_marrow-Lymphocytic_B-Pro-B\|bone_marrow / Manually curated celltypes from each tissue	DDR1 VASN GPC2 DYRK3 BAHCC1	3.08e-05	154	104	5	8a8c3851888ab86ca2b13ccc042cde1fef8d88f8
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-Sox9_Epi-Sox9_Epi_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF628 SH2D5 SIMC1 UNG HR	3.28e-05	156	104	5	b28bbdb515317368f1231b0b15d7442352f3b400
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	SIK1 EZH1 RNF43 SEC24D REPS2	3.48e-05	158	104	5	de65af8d3b8514b17978155f31975e2347b75251
ToppCell	356C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ADAM19 RPS6KA4 ABHD12B GPC2 LONRF2	4.16e-05	164	104	5	fed26f4ac36a2b0722bc7b9f91659c5e0cf4d53a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	INAFM1 TRIM7 LOX PNRC1 BAHCC1	4.54e-05	167	104	5	4ae9f2c5df13463709ea880ab035965fd99e7626
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	INAFM1 TRIM7 LOX PNRC1 BAHCC1	4.54e-05	167	104	5	4e58f9bf1e9d47720c871776ec34513ded4de9b7
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	ADAM19 STAB1 JAK3 ZNF469 LOX	4.67e-05	168	104	5	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	P28-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DDR1 ARHGEF17 KMT2C SCNN1G CCDC120	4.67e-05	168	104	5	8c8dbdbc7053f34e4ca0c5067af502fbea109fc1
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SEMA6C ADAM19 TROAP TEDC2 UNG	5.22e-05	172	104	5	6fcc16f1067672967ecbcdfdc727649ae9891dd9
ToppCell	droplet-Lung-nan-21m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SH2D5 SEC24D UNG DYRK3	5.36e-05	173	104	5	8fb32a9f2dbec16de840d55b4db7e7718f5a2a7a
ToppCell	droplet-Lung-nan-21m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SH2D5 SEC24D UNG DYRK3	5.36e-05	173	104	5	f663571aaae2365660a8b526c355f4bd1a124a74
ToppCell	NS-moderate-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	THBS4 SCNN1G LTBP2 FOXI1 CBX2	5.66e-05	175	104	5	a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PFKFB3 STAB1 TNFRSF8 TBC1D1 NFKBIE	5.98e-05	177	104	5	f28243b51be104cb3adcde63f03fc2206ed3121e
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 PRSS22 RNF43 PTPRQ SCNN1G	7.00e-05	183	104	5	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRSS22 PFKFB3 SGPP1 SCNN1G PAPPA	7.56e-05	186	104	5	aeac0c2db173cd1ea45b5052ab418d6cacd198d8
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 PRSS22 GPRIN3 PTPRQ SCNN1G	7.56e-05	186	104	5	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VASN PFKFB3 SGPP1 SCNN1G PAPPA	7.75e-05	187	104	5	b7689e7f6511920cd2beff27389555fddf685f61
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PFKFB3 SGPP1 SCNN1G PAPPA FOXI1	7.95e-05	188	104	5	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	NCKAP5L RNF43 RUSC2 ZNF469 LTBP2	7.95e-05	188	104	5	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-Trm_Th1/Th17\|lymph-node_spleen / Manually curated celltypes from each tissue	ADAM19 ABHD12B GPRIN3 PNRC1 ADAMTSL4-AS1	7.95e-05	188	104	5	a20521198c6db17589535fb439533329582c9dd2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRSS22 PFKFB3 SGPP1 SCNN1G PAPPA	7.95e-05	188	104	5	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	moderate-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	THBS4 TBC1D1 SCNN1G LTBP2 FOXI1	8.15e-05	189	104	5	6011b747e27d61d222380a7bffdd921a68e9b657
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PFKFB3 SGPP1 SCNN1G PAPPA REPS2	8.15e-05	189	104	5	c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PFKFB3 SGPP1 SCNN1G PAPPA REPS2	8.15e-05	189	104	5	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GPRIN3 PFKFB3 TBC1D1 SCNN1G PAPPA	8.35e-05	190	104	5	b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRSS22 PFKFB3 SGPP1 SCNN1G PAPPA	8.35e-05	190	104	5	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	15-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	ABHD12B LRTM1 TNFRSF8 LOX PTPRQ	8.35e-05	190	104	5	b47472dc9fe6ed99c2365203a3d8a59879e74a70
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DDR1 PFKFB3 SGPP1 SCNN1G PAPPA	8.56e-05	191	104	5	0a0719a0a49ae0099d61e22585ac74c10c24b4a2
ToppCell	facs-Diaphragm\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOD1 SBNO2 THBS4 NFKBIE NOTCH2	8.77e-05	192	104	5	486cbf9791ca619e307e8b18aa70ce22111f4f26
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VASN PFKFB3 SGPP1 SCNN1G PAPPA	8.77e-05	192	104	5	3d777d07878269b87ec7e1f06489cae7c989d633
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRSS22 PFKFB3 SGPP1 SCNN1G PAPPA	8.99e-05	193	104	5	371f4c98a599923fbe8382530b3eab05d873665a
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SCNN1G PAPPA KLHDC7A FOXI1	8.99e-05	193	104	5	536b277d90070c4571c592a3c6323b4bf4819f67
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SCNN1G PAPPA KLHDC7A FOXI1	8.99e-05	193	104	5	0499611c21d283321ef6dd24add154dea48da1b7
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	VASN ZNF469 LOX PAPPA ADAMTSL4	8.99e-05	193	104	5	adc9fc94f9ec686a417d08c0b8b7b7ab687afec0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DDR1 PFKFB3 SGPP1 SCNN1G PAPPA	9.21e-05	194	104	5	d602a0cdb69cd5a3e9ef61ddbab8d920557dd73e
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRSS22 PFKFB3 SGPP1 SCNN1G PAPPA	9.21e-05	194	104	5	158dc393639e69aecfb014f6106797214ea05fe5
ToppCell	Differ-Basal\|World / shred by cell class for mouse tongue	ABHD12B GSR STAB1 CRACDL NOTCH2	9.21e-05	194	104	5	851eff82c9f3d44c86e3e127a804bbd1fced6a7c
ToppCell	distal-Epithelial-Differentiating_Basal-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DDR1 CD177 PRSS22 MS4A15 SCNN1G	9.44e-05	195	104	5	3fe6e49a9161fc9e5160251e6932cb5378175a54
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	ADAM19 ARHGEF17 NCKAP5L RUSC2 ZNF469	9.44e-05	195	104	5	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-T-T_CD4-T_reg\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADAM19 GPRIN3 JAK3 TNFRSF8 BIN2	9.67e-05	196	104	5	c0028307cf5dddfc4b5db1445fa83b74019a20bd
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-skeletal_muscle_satellite_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOD1 BACH1 SBNO2 PNRC1 NOTCH2	9.67e-05	196	104	5	97ac47daf5bb07fa5dda3976e1ae402750f959b5
ToppCell	distal-3-Epithelial-Differentiating_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DDR1 CD177 PRSS22 MS4A15 SCNN1G	9.67e-05	196	104	5	77635a0f86910c4019d3370e9c8ba41de176bcf3
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAM19 BACH1 PFKFB3 PNRC1 ADAMTSL4-AS1	9.90e-05	197	104	5	59aa4a31674125ae422450aee45db3ced5c405d3
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BACH1 PFKFB3 PNRC1 ADAMTSL4-AS1 NOTCH2	9.90e-05	197	104	5	0c059476a8cdc6ac71a01d9c414295177f45f8de
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BACH1 PFKFB3 PNRC1 ADAMTSL4-AS1 NOTCH2	1.01e-04	198	104	5	4b6767bd6fd4bd43eed18fd4a34c20923fa795da
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RNF223 DDR1 PRSS22 MS4A15 SCNN1G	1.01e-04	198	104	5	5d57acbe0d245f8bd217eeea07af060092898fbd
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BACH1 PFKFB3 PNRC1 ADAMTSL4-AS1 NOTCH2	1.01e-04	198	104	5	18daf83309813f914b17bd226ea8a9269a26b107
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BACH1 PFKFB3 PNRC1 ADAMTSL4-AS1 NOTCH2	1.01e-04	198	104	5	72c7474e084d1334a09c0a3b0f3c3137038794c8
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BACH1 PFKFB3 STAB1 PNRC1 ADAMTSL4-AS1	1.01e-04	198	104	5	c288b29287a562460d8970264e1833801590da73
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DDR1 PRSS22 MS4A15 SCNN1G MUC5AC	1.04e-04	199	104	5	a8bfc0b93ad9968cf52a25be86995ffe436bd636
ToppCell	medial-2-Epithelial-Alveolar_Epithelial_Type_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DDR1 PRSS22 MS4A15 PFKFB3 SCNN1G	1.04e-04	199	104	5	456460c761e26ed4b1d88d9bee4d2a7c9bd9d416
ToppCell	severe-Myeloid-Neutrophils_4\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ADAM19 CD177 PFKFB3 ORAI2 JAK3	1.04e-04	199	104	5	50242666def13e5d4149c563ae000d6768f086f7
ToppCell	medial-Epithelial-Alveolar_Epithelial_Type_1-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DDR1 PRSS22 MS4A15 PFKFB3 SCNN1G	1.04e-04	199	104	5	5263338242f95c04690d0795749ccc20b0d19f7a
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RNF223 DDR1 PRSS22 TRIM7 MUC5AC	1.04e-04	199	104	5	ec1e110671e7725f752163c7241dbbf638dec2b2
ToppCell	distal-1-Hematologic-EREG+_Dendritic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SIK1 STAB1 ZNF469 PNRC1 CHRNA10	1.04e-04	199	104	5	15249f2f48b1e99d9d062835fd4c705a159e4abb
ToppCell	medial-Epithelial-Alveolar_Epithelial_Type_1\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DDR1 PRSS22 MS4A15 PFKFB3 SCNN1G	1.04e-04	199	104	5	c11365653c69a5dfb37946231f8af05149a61a71
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DDR1 VASN PRSS22 PFKFB3 SCNN1G	1.04e-04	199	104	5	5059a1d4df7d9989c922007a8dcba98b1f5687d5
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DDR1 CD177 PRSS22 SCNN1G MUC5AC	1.04e-04	199	104	5	a706ad5cd5e0dc8d7e925a05e45b07d35963f294
ToppCell	5'-Airway_Nasal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR1 PRSS22 GSR TRIM7 MUC5AC	1.06e-04	200	104	5	f6e967738b4f7b173d6e9977e305f77380dd6c8a
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR1 PRSS22 GSR TRIM7 MUC5AC	1.06e-04	200	104	5	b68d212159b9d04866ba02ff55c35be247805eec
ToppCell	5'-Airway_Nasal-Epithelial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR1 PRSS22 GSR TRIM7 MUC5AC	1.06e-04	200	104	5	358d71329921451c7f5a56f1db0f9989af2299dc
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-Unfolded_protein_responsible_cell\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TROAP PRAG1 LOX CBX2	1.16e-04	107	104	4	7fee0193ee02e9cc62f506660ea7ec23fb4d0c84
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-non-classical_monocyte\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ABHD12B CSMD3 ZNF469 CBX2	1.20e-04	108	104	4	695ed3f8cf637d767a6d79b0309d5ee82dfd063f
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MS4A15 TNFRSF8 PTPRQ SCNN1G	1.29e-04	110	104	4	c80d1c3df75648e2c8f6832279c2acca63d76681
ToppCell	Striatum-Macroglia-ASTROCYTE-Gja1\|Striatum / BrainAtlas - Mouse McCarroll V32	PRSS56 THBS4 NAPRT KLHDC7A	1.74e-04	119	104	4	d47880ef1cff036192c43646a04fa8598dd7e1f4
ToppCell	Striatum-Macroglia-ASTROCYTE\|Striatum / BrainAtlas - Mouse McCarroll V32	PRSS56 THBS4 NAPRT KLHDC7A	1.74e-04	119	104	4	0583387cc4497cf991fa42a81f2f66d9c6b774eb
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1-Excitatory_Neuron.Slc17a7.Parm1.Lsamp_(Deep_layer_pyramidal_cells--layer_5)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ABHD12B PTPRQ MUC5AC	2.17e-04	50	104	3	6790f78c37288ddf1a80934cae6309b61a929ac6
Disease	cystitis (is_marker_for)	MUC2 MUC5AC	1.14e-05	2	100	2	DOID:1679 (is_marker_for)
Disease	sputum mucin-5B amount	MUC2 MUC5AC	3.40e-05	3	100	2	OBA_2050332
Disease	mucinous adenocarcinoma (is_marker_for)	MUC2 MUC5AC	1.13e-04	5	100	2	DOID:3030 (is_marker_for)
Disease	Liver Diseases, Parasitic	RNF43 KMT2C	4.03e-04	9	100	2	C0023897
Disease	bringing up phlegm, sputum or mucus on most days, self-reported	MUC2 MUC5AC	4.03e-04	9	100	2	EFO_0009824
Disease	Colorectal Carcinoma	ADAM19 CSMD3 RNF43 KMT2C SCNN1G UNG ACTL9 LONRF2 HR	6.44e-04	702	100	9	C0009402
Disease	level of Phosphatidylethanolamine (16:0_20:4) in blood serum	POLR2M RNF111	1.32e-03	16	100	2	OBA_2045137
Disease	cholangiocarcinoma (is_marker_for)	PRSS56 MUC2 MUC5AC	1.35e-03	64	100	3	DOID:4947 (is_marker_for)
Disease	level of Phosphatidylethanolamine (18:0_20:4) in blood serum	POLR2M RNF111	1.87e-03	19	100	2	OBA_2045140
Disease	psoriasis	DDR1 ADAM19 RPS6KA4 RUSC2 BPTF	2.41e-03	273	100	5	EFO_0000676
Disease	Intrahepatic Cholangiocarcinoma	RNF43 KMT2C	2.99e-03	24	100	2	C0345905
Disease	stomach carcinoma (is_marker_for)	RNF43 KMT2C	2.99e-03	24	100	2	DOID:5517 (is_marker_for)
Disease	Extrahepatic Cholangiocarcinoma	RNF43 KMT2C	2.99e-03	24	100	2	C3805278

Protein segments in the cluster

Peptide	Gene	Start	Entry
CFSVQRPVPPPPSLE	UNG	166	P13051
PCGQSRPPELSPSPQ	CHRNA10	356	Q9GZZ6
PPAVLPPCARGNSEP	BACH1	676	O14867
PAQPPTANPCSGPRL	BAHCC1	1391	Q9P281
QAPCPPEQPDPRALQ	ADAMTSL4	376	Q6UY14
QLRVCQPPPPVPNAE	CSMD3	2391	Q7Z407
DIQCCPAPPSAPPRA	ADAMTSL4-AS1	6	Q5T5F5
PSRPIPPAPNCIVSQ	ADAM19	836	Q9H013
SQRRPPPPGMEVCPQ	C2orf27A	181	P0DPF5
EPRPRGNPPHSAPCV	DDR1	486	Q08345
CRQEPQPQGPPPAAG	GSR	46	P00390
CQAAASPEPPGPPAR	ABHD12B	6	Q7Z5M8
EAPRPGPNPSPNVVN	ACTL9	16	Q8TC94
APQPPADPGSLRCPV	CD177	121	Q8N6Q3
SLPPQAAPVPGDRQC	CD177	311	Q8N6Q3
QPAAPAAERCAPAPP	BPTF	11	Q12830
PLPACNGPAQAQPSP	BIN2	336	Q9UBW5
EGQRLPAPPACPAEV	JAK3	1056	P52333
LKTSAPRPPCQPQPG	OCEL1	91	Q9H607
NVPIDPSAPACPEPG	ORAI2	6	Q96SN7
VPGLQPRCHREPPPS	ARHGEF17	1556	Q96PE2
AQPAGAPQPQSTCPP	NOTCH2	2316	Q04721
APQPQSTCPPAVAGP	NOTCH2	2321	Q04721
PPGPASCQPGRQPLS	KRBA1	341	A5PL33
PCPLPAPDPVSSQAQ	LRTM1	231	Q9HBL6
VRPPDTCSQTPRPPG	KMT2C	2266	Q8NEZ4
SPEPINGELCGPPQP	NCKAP5L	221	Q9HCH0
PAFPGQEPRCGPEPT	FAAP20	61	Q6NZ36
QVFQECGPPDPVPAR	GPC2	341	Q8N158
PPRAGRPLCQADPQP	NFKBIE	101	O00221
QCLSPAPRPPGEPVS	MAPK8IP2	371	Q13387
NAARIPVPPACGKPQ	PRSS22	31	Q9GZN4
QLPPECPLEPGERPQ	CCDC120	66	Q96HB5
TPRCPSPEPPVTQRG	HR	311	O43593
PCLTPQPRAPAALPN	PNRC1	66	Q12796
GTKPPECPDFDPPRQ	MUC2	4406	Q02817
PDAAPQCPAGANPNP	MYOD1	301	P15172
PSCLPPEVPTQLPGQ	PFKFB3	491	Q16875
PQNCGPPDDFRCPNP	HERC4	381	Q5GLZ8
KCSPPFPPRIGPVAQ	RPS6KA4	256	O75676
PPQCPGCDRAEPIAQ	LONRF2	11	Q1L5Z9
CPLPGFVPVPAAPQA	MUC5AC	5321	P98088
QEGACVPVTCDPPPP	PAPPA	1406	Q13219
PGTREPCPAAQEPAP	CRACDL	661	Q6NV74
QPRTTPPPGAQCEVP	PAIP1	61	Q9H074
PPPGAQCEVPASPQR	PAIP1	66	Q9H074
RTPESVPEGPPQNCV	PTPRQ	341	Q9UMZ3
VPAGCPGPQPAPTQE	CBX2	336	Q14781
GPAEEAECPPPRQPQ	POLR2M	21	Q6EEV4
DPRTPAGPQFRCLPP	COL20A1	161	Q9P218
PTPGCQLPRPNCPVE	CDK7	301	P50613
RPPDAGCCQAPEQPP	FBXL17	241	Q9UF56
KRQPCAGPDTPIPPA	INPP5K	276	Q9BT40
PAGQPPGAVPCAQPR	GLI4	126	P10075
PNNASGLCPPPAILP	MS4A15	16	Q8N5U1
PCPPRPASPVIENGQ	LTBP2	591	Q14767
IPAPEAARQCAPPPA	HOXC13	96	P31276
CAPPAAGQQQPPREP	LOX	21	P28300
QLQPDGFRLPAPPCP	KLHDC7A	376	Q5VTJ3
PPRCSPQFPSIGQEP	FOXI1	11	Q12951
ACPPGPEKVPLPAQR	GPRIN3	276	Q6ZVF9
KQAPPCPEAPRSPQG	SCNN1G	576	P51170
CPEAPRSPQGQDNPA	SCNN1G	581	P51170
CPQLGVPAPPSEAPQ	POLRMT	726	O00411
PRSVQEAPCSPQGPP	C3orf86	51	P0DN24
EAPCSPQGPPAQRPA	C3orf86	56	P0DN24
CSNVLCNPSEPPPPR	DYRK3	46	O43781
PPTTAVPCPRDDPQA	FAM8A1	31	Q9UBU6
VPCPRDDPQAEPQAP	FAM8A1	36	Q9UBU6
SARPVCLPQEPQEPP	PRSS56	206	P0CW18
CAARPGVPPVPAPAA	INAFM1	76	C9JVW0
AVAPEPCPQPLRSPS	IRF3	161	Q14653
CQLSVPPGRAAAPPP	FOXD2	306	O60548
AQTACLPPPRPQRPV	NUTM2E	461	B1AL46
RPNPFCPPELGITQP	RUSC2	41	Q8N2Y8
PLIQASRPCPAAQPP	SUPT20HL1	511	Q3ZLR7
REGPIPEPCALAPNP	PRR23A	191	A6NEV1
PAPGTGIPVAPVNCP	TCP11X1	286	B4DZS4
AAVAEQPPRPCPVGR	TEDC2	321	Q7L2K0
PEERAQPEPCPGPTG	SH2D5	151	Q6ZV89
GEDCPSPQPAPASPR	PPARGC1B	251	Q86YN6
SNPQCPRALPEPAPG	RNF43	611	Q68DV7
PQPPGSDRNQCPAKP	SGPP1	66	Q9BX95
PQEVPCPRQNIPGPP	SIMC1	246	Q8NDZ2
PGCSQAPQPAPAPFV	SIK1B	671	A0A0B4J2F2
APQPAPAPFVIAPCD	SIK1B	676	A0A0B4J2F2
PGCSQAPQPAPAPFV	SIK1	671	P57059
APQPAPAPFVIAPCD	SIK1	676	P57059
RQAPALGCPAPPAPR	SBNO2	1231	Q9Y2G9
PQRFPGPPPVNNVAS	SEC24D	81	O94855
GPCQRTQGPELPPPD	ACD	241	Q96AP0
VPCPFCRQPTAVPPA	RNF223	96	E7ERA6
VPPGPDNCRLVPNPA	THBS4	676	P35443
NNPPLPGVQAPCSPK	TULP4	1196	Q9NRJ4
SPAPPARSEEPCEQP	USP42	856	Q9H9J4
GAATRAPPFPLPCPQ	TRIM7	66	Q9C029
PALPPRPCPSQSEQV	REPS2	516	Q8NFH8
ACPVERPPQVQAPCG	RNF111	536	Q6ZNA4
PVCRPEDPLPGPSNI	REV1	146	Q9UBZ9
FLNPAPPCGEPDTRP	SLC5A10	491	A0PJK1
PIECQEPPQPARGSP	TBC1D1	601	Q86TI0
PNALPPQCTPNIDGP	EZH1	266	Q92800
PGVDRQPPHSRPCLP	FAM90A2P	356	Q658T7
APPLGTQPDCNPTPE	TNFRSF8	326	P28908
PCPSPFGRAQRVPSP	TROAP	321	Q12815
RPPPPGCPGQAVEVT	SEMA6C	751	Q9H3T2
ESEPPVDRCLGQPPP	STAB1	2176	Q9NY15
PPGAQEPCTVRPAQV	NAPRT	456	Q6XQN6
QPPSQGPADPAPSCR	PRAG1	586	Q86YV5
ARDPAPCPASAPEQP	SNX19	271	Q92543
GPVPQPQDCPPSTCL	VASN	401	Q6EMK4
QLPASPSCRDPPGPQ	ZNF469	2121	Q96JG9
AALPPRASGPPPCQV	ZBTB42	166	B2RXF5
PRCFSGPPPRAPKQV	PRR30	371	Q53SZ7
CPGPDAAPQPQEAPA	ZNF628	316	Q5EBL2
VTCPQEPLAPAAPVP	ZNF628	426	Q5EBL2
PDIPPPQPDCGDFRS	SLC4A1AP	116	Q9BWU0