Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of skin epidermis

KRT2 KRT76 KRT75 KRT85

3.68e-0643494GO:0030280
GeneOntologyMolecularFunctionstructural constituent of presynaptic active zone

PCLO RIMBP2

1.64e-048492GO:0098882
GeneOntologyMolecularFunctionstructural molecule activity

KRT2 KRT76 VWF KRT75 KRT27 KRT85 PCLO RIMBP2 SSPOP

2.77e-04891499GO:0005198
GeneOntologyBiologicalProcessintermediate filament organization

KRT2 KRT76 KRT75 KRT27 KRT85

9.35e-0775495GO:0045109
GeneOntologyBiologicalProcessintermediate filament cytoskeleton organization

KRT2 KRT76 KRT75 KRT27 KRT85

3.71e-0699495GO:0045104
GeneOntologyBiologicalProcessintermediate filament-based process

KRT2 KRT76 KRT75 KRT27 KRT85

3.90e-06100495GO:0045103
GeneOntologyBiologicalProcesskeratinization

KRT2 KRT76 KRT75 KRT85

5.41e-0587494GO:0031424
GeneOntologyBiologicalProcesspresynaptic actin cytoskeleton organization

ARHGEF7 PCLO

5.50e-055492GO:0099140
GeneOntologyBiologicalProcesspresynaptic cytoskeleton organization

ARHGEF7 PCLO

8.24e-056492GO:0099187
GeneOntologyCellularComponentkeratin filament

KRT2 KRT76 KRT75 KRT85

7.86e-0597494GO:0045095
GeneOntologyCellularComponentintermediate filament

KRT2 KRT76 KRT75 KRT27 KRT85

1.87e-04227495GO:0005882
GeneOntologyCellularComponentintermediate filament cytoskeleton

KRT2 KRT76 KRT75 KRT27 KRT85

3.68e-04263495GO:0045111
MousePhenorough coat

KRT76 KRT75 KRT27

4.21e-0524403MP:0010179
DomainKeratin_2_head

KRT2 KRT76 KRT75 KRT85

4.64e-0724504IPR032444
DomainKeratin_2_head

KRT2 KRT76 KRT75 KRT85

4.64e-0724504PF16208
DomainKeratin_II

KRT2 KRT76 KRT75 KRT85

6.50e-0726504IPR003054
DomainFilament

KRT2 KRT76 KRT75 KRT27 KRT85

1.28e-0671505SM01391
DomainIF

KRT2 KRT76 KRT75 KRT27 KRT85

1.37e-0672505PS00226
DomainFilament

KRT2 KRT76 KRT75 KRT27 KRT85

1.47e-0673505PF00038
DomainIF

KRT2 KRT76 KRT75 KRT27 KRT85

1.79e-0676505IPR001664
DomainIntermediate_filament_CS

KRT2 KRT76 KRT75 KRT85

2.41e-0563504IPR018039
DomainNdr

NDRG1 NDRG2

4.20e-054502PF03096
DomainNDRG

NDRG1 NDRG2

4.20e-054502IPR004142
DomainTIL

VWF SSPOP

4.56e-0412502PF01826
DomainC8

VWF SSPOP

4.56e-0412502PF08742
DomainUnchr_dom_Cys-rich

VWF SSPOP

5.38e-0413502IPR014853
DomainC8

VWF SSPOP

5.38e-0413502SM00832
DomainTIL_dom

VWF SSPOP

6.26e-0414502IPR002919
DomainTSP_1

ADGRB2 ISM2 SSPOP

6.40e-0463503PF00090
DomainZnf_FYVE_PHD

PHF20L1 PCLO MLLT6 PHF10

6.40e-04147504IPR011011
DomainTSP1

ADGRB2 ISM2 SSPOP

7.02e-0465503SM00209
DomainTSP1_rpt

ADGRB2 ISM2 SSPOP

7.02e-0465503IPR000884
DomainTSP1

ADGRB2 ISM2 SSPOP

7.02e-0465503PS50092
DomainVWD

VWF SSPOP

8.23e-0416502SM00216
DomainVWF_type-D

VWF SSPOP

8.23e-0416502IPR001846
DomainVWFD

VWF SSPOP

8.23e-0416502PS51233
DomainVWD

VWF SSPOP

8.23e-0416502PF00094
DomainCTCK_1

VWF SSPOP

1.05e-0318502PS01185
DomainVWC_out

VWF SSPOP

1.17e-0319502SM00215
DomainCys_knot_C

VWF SSPOP

2.03e-0325502IPR006207
DomainCTCK_2

VWF SSPOP

2.03e-0325502PS01225
DomainZF_PHD_1

PHF20L1 MLLT6 PHF10

2.17e-0396503PS01359
DomainVWFC_1

VWF SSPOP

4.18e-0336502PS01208
DomainVWC

VWF SSPOP

4.64e-0338502SM00214
DomainVWFC_2

VWF SSPOP

4.64e-0338502PS50184
DomainLDLR_class-A_CS

CFI SSPOP

5.13e-0340502IPR023415
DomainVWF_dom

VWF SSPOP

5.65e-0342502IPR001007
DomainKeratin_I

KRT76 KRT27

6.18e-0344502IPR002957
DomainLdl_recept_a

CFI SSPOP

6.46e-0345502PF00057
Domain-

CFI SSPOP

6.74e-03465024.10.400.10
DomainLDLRA_1

CFI SSPOP

7.32e-0348502PS01209
DomainLDLRA_2

CFI SSPOP

7.62e-0349502PS50068
DomainLDrepeatLR_classA_rpt

CFI SSPOP

7.62e-0349502IPR002172
DomainLDLa

CFI SSPOP

7.62e-0349502SM00192
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT2 KRT76 KRT75 KRT27 KRT85

4.43e-0687405MM15351
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT2 KRT76 KRT75 KRT27 KRT85

3.02e-05129405M27649
PathwayREACTOME_KERATINIZATION

KRT2 KRT76 KRT75 KRT27 KRT85

6.83e-05153405MM15343
Pubmed

New consensus nomenclature for mammalian keratins.

KRT2 KRT76 KRT75 KRT27 KRT85

3.65e-086351516831889
Pubmed

Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.

KRT2 KRT75 KRT85

1.64e-061651312399393
Pubmed

NDRG1/2 expression is inhibited in primary acute myeloid leukemia.

NDRG1 NDRG2

2.11e-06251219775754
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADGRB2 CUBN ISM2 SSPOP

4.62e-067551420637190
Pubmed

RNA-binding protein CUGBP1 regulates insulin secretion via activation of phosphodiesterase 3B in mice.

PDE3B CELF1

6.32e-06351227255754
Pubmed

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.

NDRG1 NDRG2

6.32e-06351226443704
Pubmed

N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom.

NDRG1 NDRG2

6.32e-06351210831399
Pubmed

Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.

NDRG1 NDRG2

6.32e-06351220551432
Pubmed

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3.

NDRG1 NDRG2

6.32e-06351215461589
Pubmed

Differential expression patterns of NDRG family proteins in the central nervous system.

NDRG1 NDRG2

1.26e-05451217998568
Pubmed

Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart.

NDRG1 NDRG2

1.26e-05451211352569
Pubmed

Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc.

NDRG1 NDRG2

1.26e-05451210581191
Pubmed

Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.

NDRG1 NDRG2

1.26e-05451211936845
Pubmed

The mouse Psma1 gene coding for the alpha-type C2 proteasome subunit: structural and functional analysis, mapping, and colocalization with Pde3b on mouse chromosome 7.

PDE3B PSMA1

1.26e-05451210873386
Pubmed

The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo.

ARHGEF7 PCLO

2.10e-05551212473661
Pubmed

Ndr kinases regulate retinal interneuron proliferation and homeostasis.

NDRG1 NDRG2

2.10e-05551230135513
Pubmed

Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway.

NDRG1 NDRG2

2.10e-05551224928906
Pubmed

ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.

KRT2 KRT76 KRT75 CPT1B

2.35e-0511351434474245
Pubmed

Differentiation-related gene-1 decreases Bim stability by proteasome-mediated degradation.

NDRG1 BCL2L11

3.15e-05651219622774
Pubmed

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.

NDRG1 NDRG2

3.15e-05651236446521
Pubmed

NDRG2 and PRA1 interact and synergistically inhibit T-cell factor/β-catenin signaling.

NDRG1 NDRG2

4.41e-05751223068607
Pubmed

Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy.

IRS4 NHS

5.87e-05851232371981
Pubmed

Molecular enzymology of carnitine transfer and transport.

PRKAG2 CPT1B

7.54e-05951211257506
Pubmed

RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.

KRT2 KRT76 KRT75

8.22e-055751331862882
Pubmed

Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.

NDRG1 CUBN

9.42e-051051217302988
Pubmed

Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.

KRT75 KRT85

1.38e-041251210692104
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

KRT2 KRT76 VWF ARGLU1 PCLO ARFGEF2 DLST RIMBP2 PRKAG2

2.10e-04143151937142655
Pubmed

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2.

VWF CFI

2.19e-041551236305765
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

KRT2 IRS4 POLR1A KRT75

2.23e-0420251424639526
Pubmed

NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development.

NDRG1 NDRG2

2.50e-041651226305214
Pubmed

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

PRKAG2 CPT1B

3.18e-041851216054041
Pubmed

Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.

KRT75 KRT85

3.55e-041951227234308
Pubmed

Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.

PDE3B PSMA1

3.55e-041951225208829
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

CDCA2 KRT2 ARGLU1 PCLO NCSTN

3.94e-0442551524999758
Pubmed

DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.

KRT2 KRT75 KRT85 DLST

4.15e-0423851435864588
Pubmed

Charting the molecular network of the drug target Bcr-Abl.

KRT2 KRT76 KRT75 KRT85

6.30e-0426651419380743
Pubmed

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.

KRT2 KRT75 ARGLU1 KRT85 DLST

7.36e-0448851531324722
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

CDCA2 KRT2 POLR1A PLAA PSMA1 DLST FASTKD2 ZNF512

7.38e-04135351829467282
Pubmed

Physiological and pathophysiological characteristics of ataxin-3 isoforms.

KRT2 IRS4 PSMA1 DLST

7.73e-0428151430455355
Pubmed

A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.

NDRG1 NDRG2

7.78e-042851225912685
Pubmed

Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.

PSMA1 FASTKD2

7.78e-042851228655764
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

KRT2 KRT76 KRT75 KRT27 PSMA1 CUBN CFI

9.09e-04107051723533145
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

CDCA2 IRS4 POLR1A PSMA1 PCLO DLST FASTKD2 ZNF512

1.03e-03142551830948266
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ARHGEF7 PCNX1 FASTKD2 NCSTN DNA2

1.05e-0352951514621295
Pubmed

Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.

ARHGEF7 CFI

1.08e-033351224204828
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

BCL2L11 ADGRB2 ARFGEF2 PCNX1 MLLT6 TNFRSF21 KLHL17

1.10e-03110551735748872
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CDCA2 KRT2 KRT76 IRS4 KRT75 PHF20L1 PCLO DLST

1.11e-03144251835575683
Pubmed

Hypertrophic Cardiomyopathy Overview

PRKAG2 CHST3

1.15e-033451220301725
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

KRT2 KRT76 KRT75 KRT27 PSMA1 NCSTN PHF10

1.40e-03115351729845934
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

PDE3B IRS4 ARGLU1 PSMA1 PCLO DLST FASTKD2 ZNF512

1.41e-03149651832877691
InteractionKRT25 interactions

KRT2 KRT76 KRT75 KRT85

1.53e-0635494int:KRT25
InteractionKRT37 interactions

KRT2 KRT76 KRT75 PSMA1 KRT85

4.36e-06100495int:KRT37
InteractionKRT35 interactions

KRT2 KRT76 KRT75 KRT27 KRT85

7.28e-06111495int:KRT35
InteractionKRT13 interactions

KRT2 KRT76 KRT75 PSMA1 KRT85

9.02e-06116495int:KRT13
InteractionPRPH interactions

KRT2 KRT76 KRT75 KRT27 PSMA1 DLST

9.73e-06204496int:PRPH
InteractionPHTF1 interactions

KRT2 KRT76 KRT75

1.50e-0520493int:PHTF1
InteractionKRT20 interactions

KRT2 KRT76 KRT75 KRT27

1.65e-0563494int:KRT20
InteractionKRT12 interactions

KRT2 KRT76 KRT75

2.64e-0524493int:KRT12
InteractionKRT36 interactions

KRT2 KRT76 KRT75 KRT85

3.13e-0574494int:KRT36
InteractionKRT7 interactions

KRT2 KRT76 KRT75 KRT27

4.26e-0580494int:KRT7
InteractionKRT19 interactions

KRT2 KRT76 KRT75 PSMA1 KRT85 MLLT6

6.01e-05282496int:KRT19
InteractionKRT38 interactions

KRT2 KRT76 KRT75 PSMA1 KRT85

6.01e-05172495int:KRT38
InteractionKRT15 interactions

KRT2 KRT76 KRT75 PSMA1 KRT85

7.07e-05178495int:KRT15
InteractionKRT33B interactions

KRT2 KRT76 KRT75 KRT85

7.68e-0593494int:KRT33B
InteractionKRT26 interactions

KRT76 KRT75 KRT85

8.37e-0535493int:KRT26
InteractionKRT16 interactions

KRT2 KRT76 KRT75 KRT85 ARFGEF2

1.14e-04197495int:KRT16
InteractionKRT27 interactions

KRT2 KRT76 KRT75 KRT27 KRT85

1.28e-04202495int:KRT27
InteractionKRT32 interactions

KRT2 KRT76 KRT75

1.67e-0444493int:KRT32
InteractionKRT84 interactions

KRT2 KRT76 KRT75

2.30e-0449493int:KRT84
CytobandEnsembl 112 genes in cytogenetic band chr12q13

KRT2 KRT76 KRT75 KRT85

1.26e-03423514chr12q13
CytobandEnsembl 112 genes in cytogenetic band chr14q24

PCNX1 DLST ISM2

1.45e-03200513chr14q24
Cytoband11p15.1

PDE3B PSMA1

2.06e-036051211p15.1
Cytoband12q13.13

KRT2 KRT76

2.55e-036751212q13.13
Cytoband12q13

KRT75 KRT85

2.86e-037151212q13
Cytoband7q36.1

PRKAG2 SSPOP

3.11e-03745127q36.1
Cytoband14q24.3

DLST ISM2

4.85e-039351214q24.3
GeneFamilyKeratins, type II

KRT2 KRT76 KRT75 KRT85

1.57e-0727334609
GeneFamilyPHD finger proteins

PHF20L1 MLLT6 PHF10

5.84e-049033388
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

CDCA2 WDR81 RIMBP2

4.32e-03181333694
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B NDRG1 RIMBP2 TOP6BL PRKAG2

1.17e-06162515285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B PSMA1 RIMBP2 TOP6BL PRKAG2

1.24e-061645156fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B PSMA1 RIMBP2 TOP6BL PRKAG2

2.07e-06182515f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B NDRG1 RIMBP2 TOP6BL PRKAG2

2.13e-06183515b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

NDRG1 PCLO NHS RIMBP2 CUBN

2.36e-06187515d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B NDRG1 RIMBP2 TOP6BL PRKAG2

2.36e-06187515f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B PSMA1 RIMBP2 TOP6BL PRKAG2

2.49e-061895158ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B NDRG1 RIMBP2 TOP6BL PRKAG2

2.69e-0619251540f44ac4ab673ee6156abdd2074a60b9de3281ad
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B NDRG1 RIMBP2 TOP6BL PRKAG2

2.83e-061945154d6c9b016e3a0641954a8ea10c97d1cd76fadd9f
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tfh|GI_small-bowel / Manually curated celltypes from each tissue

ADGRB2 OBSCN-AS1 DNA2 ZNF512

1.69e-05134514bf94ce5edde8912a27010e229c313d8102d6de62
ToppCellNS-moderate-d_16-33-Epithelial-unknown_epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PLK2 IRS4 NDRG1 ARGLU1

1.84e-0513751403e124901a0e85b59b6882bbafab568b50907e8b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 RIMBP2 TOP6BL PRKAG2

2.43e-0514751464fa0753a3a79f492ef8acc6942bf90d379a983f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 RIMBP2 TOP6BL PRKAG2

2.69e-0515151410da94037225a71844281ddcb395072250a78094
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B PSMA1 TOP6BL PRKAG2

4.18e-051695140332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO PCNX1 RIMBP2 PRKAG2

4.69e-05174514f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDRG1 WDR81 CUBN CFI

5.01e-051775142bf639e9e801e5144462ffc957f5739e0dfcd500
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDRG1 WDR81 CUBN CFI

5.01e-051775149c7c6824b9011363851f084a500d665f025b026e
ToppCell390C-Lymphocytic-ILC-ILC-1|390C / Donor, Lineage, Cell class and subclass (all cells)

PDE3B POLR1A KRT85 ZNF512

5.23e-05179514e7045e27f0eb88f552b31c04b56d78e5ccd7a36c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B PSMA1 TOP6BL PRKAG2

5.35e-05180514788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B RIMBP2 TOP6BL PRKAG2

5.46e-05181514aa233b652921848af2257cc3687a7a09c3acfb67
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCLO NHS RIMBP2 CUBN

5.58e-051825149d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B RIMBP2 TOP6BL PRKAG2

5.70e-05183514d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 RIMBP2 TOP6BL PRKAG2

5.95e-05185514a0a629e5d2b65f670ea907bd3f5e3caf17687d8f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 RIMBP2 TOP6BL PRKAG2

5.95e-05185514d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCellCOVID-19-kidney-CD-PC|COVID-19 / Disease (COVID-19 only), tissue and cell type

NDRG1 RIMBP2 TOP6BL PRKAG2

6.33e-051885148f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B RIMBP2 TOP6BL PRKAG2

6.33e-051885144154f4787483c7e076e87a187733a9f666742c3d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 RIMBP2 TOP6BL PRKAG2

6.46e-051895143a295c215b5c18e7c673f92b7af5be523421682c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 RIMBP2 TOP6BL PRKAG2

6.46e-05189514c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 RIMBP2 TOP6BL PRKAG2

6.46e-05189514fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 ARHGEF7 RIMBP2 PRKAG2

6.46e-05189514a48df46274d51e84ffb40264646de7346104efb9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 RIMBP2 TOP6BL PRKAG2

6.59e-0519051411d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B PSMA1 RIMBP2 TOP6BL

6.59e-051905144836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B RIMBP2 TOP6BL PRKAG2

6.73e-0519151496b78b4e819ea6052334bfcbc7abbf35897df885
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 RIMBP2 TOP6BL PRKAG2

6.87e-05192514fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NDRG1 RIMBP2 TOP6BL PRKAG2

6.87e-05192514bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCellCOVID-19-kidney-CD-PC|kidney / Disease (COVID-19 only), tissue and cell type

NDRG1 RIMBP2 TOP6BL PRKAG2

7.01e-05193514738689d009e4b118d7ce3171a207294b95cbe78b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B NDRG1 TOP6BL PRKAG2

7.15e-05194514be869e186386d03ebb670971dd24fa656b4b0edf
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLK2 VWF NDRG1 CFI

7.29e-0519551481a98ebb0d43f416f9a8bba580531dc0cfea8f74
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLK2 VWF NDRG1 CFI

7.44e-051965145609b2d93172a488b35d854298a3a4e504e17e28
ToppCellCOVID-19-lung-Capillary_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

PDE3B VWF ARGLU1 PSMA1

7.44e-05196514ac28e9be288af6f00a841aea4ce4b99aed6b4505
ToppCellmedial-Endothelial-Vein-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLK2 VWF NDRG1 CFI

8.04e-052005143f689029f5bc7db0af50a405f1e252aeec529077
ToppCellmedial-Endothelial-Vein|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLK2 VWF NDRG1 CFI

8.04e-052005141163e5f6dfb304c94bf8885629350454f4b6bee8
ToppCelldistal-Endothelial-Vein|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLK2 VWF NDRG1 CFI

8.04e-052005146acf7afe122f81a95c4c66f4d0878d997b57127a
ToppCellmedial-2-Endothelial-Vein|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLK2 VWF NDRG1 CFI

8.04e-0520051449da4e3ff10262a492c2cf566a7f2e35e418bfda
DrugEthambutol dihydrochloride [1070-11-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A

PLAA ARHGEF7 PCLO TOP6BL NDRG2 TNFRSF21

4.92e-061965164120_DN
Disease5-methyluridine (ribothymidine) measurement

PCLO CPT1B

2.43e-0414492EFO_0020013
DiseaseProteinuria

VWF CUBN

2.80e-0415492HP_0000093
Diseasediet measurement, fasting blood insulin measurement

ARHGEF7 CFI

6.11e-0422492EFO_0004466, EFO_0008111
Diseasediet measurement, HOMA-IR

ARHGEF7 CFI

6.68e-0423492EFO_0004501, EFO_0008111
Diseaseresponse to angiotensin receptor blocker

POLR1A PRKAG2

1.14e-0330492EFO_0010735

Protein segments in the cluster

PeptideGeneStartEntry
CSRSCGRGSRSRMRT

ADGRB2

376

O60241
RSPRRMSFSGIFRSS

PRKAG2

116

Q9UGJ0
IMRFSTTTSSSGRAR

MLLT6

406

P55198
TSLAECTFTKRRTMG

CFI

191

P05156
LSRGCAFVTFTTRAM

CELF1

146

Q92879
MGRSRSRSSSRSKHT

ARGLU1

1

Q9NWB6
RRCSVTSMESTVSSG

ARFGEF2

611

Q9Y6D5
IFMRRSSLLSRSSSG

BCL2L11

81

O43521
RMGSTSRKSCCSYIS

ARHGEF7

786

Q14155
STATCMRRSSIQSTF

NCSTN

226

Q92542
SAVVSGSSRMSCVAR

KRT76

21

Q01546
SMSRSATAACRAQLS

FAM189A1

436

O60320
TRMSVLSFCRSHTVS

OR8D2

161

Q9GZM6
MSCRSYRISSGCGVT

KRT85

1

P78386
GGSRRSTSSFSCLSR

KRT2

31

P35908
TARFCLRSMLSGESS

ISM2

471

Q6H9L7
TQSTFSTMGTVSRRR

PCLO

3736

Q9Y6V0
STMGTVSRRRICRTN

PCLO

3741

Q9Y6V0
SSLRMSTTGFVPCRR

PCNX1

2136

Q96RV3
RSISSLMGAFSGSCR

PDE3B

381

Q13370
TRLMRSRTASGSSVT

NDRG1

321

Q92597
MSVRFSSTSRRLGSC

KRT27

1

Q7Z3Y8
MARRGFSCLLLSTTA

MTRNR2L9

1

P0CJ76
CRAMSIGARSQSART

PSMA1

156

P25786
MLSRSRCVSRAFSRS

DLST

1

P36957
RRMGSGDSSRSCETS

PHF10

46

Q8WUB8
SSTMSRLARTCGREQ

CUBN

1571

O60494
AASCMFTRRSSVGVA

KLHL17

606

Q6TDP4
RRTICTFDSSGFESM

CDCA2

921

Q69YH5
SGTSIASSIRCMRRA

DNA2

126

P51530
MFREGRTETVRSCTS

CPT1B

596

Q92523
MGCSSSSTKTRRSDT

PPEF1

1

O14829
SFSRTSRSCSRFLKG

OBSCN-AS1

56

Q96MR7
LTRSSGSSLASRSMF

PHF20L1

601

A8MW92
MASCSFTRDQATRRL

IRS4

1

O14654
TFLSRSGSARCRSES

RIMBP2

136

O15034
VSGASMTTRGCFFTR

POLR1A

636

O95602
RGSSRSLMEFSTCGL

SSPOP

3066

A2VEC9
LASCSRIARRATATM

TNFRSF21

11

O75509
SIMSILTGSTRSSFR

TOP6BL

401

Q8N6T0
RSRLSRMAADSGSCD

NHS

581

Q6T4R5
CMTRLSRSRTASLTS

NDRG2

321

Q9UN36
FSTLVSTSRTMRLCC

FASTKD2

31

Q9NYY8
TQFMFRRGSSRSLCE

CHST3

216

Q7LGC8
TRGRSSTARCSLFGS

VWF

26

P04275
FGRTTTAKSVCRMLS

NPVF

131

Q9HCQ7
MTRSCSAVGCSTRDT

THAP9

1

Q9H5L6
MTSGATRYRLSCSLR

PLAA

1

Q9Y263
RMIVRGTLGSCSSSS

PLK2

446

Q9NYY3
LRCMRESCSSSFTSI

ZNF512

251

Q96ME7
MAASRSTRVTRSTVG

ZZZ3

1

Q8IYH5
TMASSDSTLRFVDCR

WDR81

1756

Q562E7
MSRQSSITFQSGSRR

KRT75

1

O95678