Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsemaphorin receptor activity

NRP1 PLXNC1 PLXNA1

6.08e-05121333GO:0017154
GeneOntologyBiologicalProcessprotein localization to early endosome

EZR RDX NRP1 MSN NF2

3.95e-08161315GO:1902946
GeneOntologyBiologicalProcesspositive regulation of early endosome to late endosome transport

EZR RDX MSN NF2

1.91e-0791314GO:2000643
GeneOntologyBiologicalProcessregulation of protein localization to early endosome

EZR RDX MSN NF2

3.17e-07101314GO:1902965
GeneOntologyBiologicalProcesspositive regulation of protein localization to early endosome

EZR RDX MSN NF2

3.17e-07101314GO:1902966
GeneOntologyBiologicalProcesspositive regulation of protein localization to endosome

EZR RDX MSN NF2

1.48e-06141314GO:1905668
GeneOntologyBiologicalProcessprotein localization to endosome

EZR RDX NRP1 MSN NF2

1.97e-06331315GO:0036010
GeneOntologyBiologicalProcessregulation of protein localization to endosome

EZR RDX MSN NF2

2.01e-06151314GO:1905666
GeneOntologyBiologicalProcessregulation of cell morphogenesis

EZR KALRN WNT5A RDX CORO1B BRWD3 MSN RHOG NF2 PLXNC1 PLXNA1

3.69e-0630213111GO:0022604
GeneOntologyBiologicalProcessregulation of early endosome to late endosome transport

EZR RDX MSN NF2

6.96e-06201314GO:2000641
GeneOntologyBiologicalProcessregulation of cell shape

EZR RDX BRWD3 MSN RHOG NF2 PLXNC1 PLXNA1

8.11e-061591318GO:0008360
GeneOntologyBiologicalProcessestablishment of epithelial cell apical/basal polarity

EZR WNT5A LAMA1 MSN

8.55e-06211314GO:0045198
GeneOntologyBiologicalProcessearly endosome to late endosome transport

EZR WDR81 RDX MSN NF2

1.61e-05501315GO:0045022
GeneOntologyBiologicalProcessgland morphogenesis

EZR WNT5A LAMA1 PTCH1 NRP1 MSN FGFR1 PLXNA1

1.84e-051781318GO:0022612
GeneOntologyBiologicalProcessestablishment of apical/basal cell polarity

EZR WNT5A LAMA1 MSN

2.08e-05261314GO:0035089
GeneOntologyBiologicalProcessvesicle-mediated transport between endosomal compartments

EZR WDR81 RDX MSN NF2

2.82e-05561315GO:0098927
GeneOntologyBiologicalProcessestablishment of monopolar cell polarity

EZR WNT5A LAMA1 MSN

2.83e-05281314GO:0061162
GeneOntologyBiologicalProcessbranching involved in salivary gland morphogenesis

LAMA1 NRP1 FGFR1 PLXNA1

2.83e-05281314GO:0060445
GeneOntologyBiologicalProcessestablishment or maintenance of monopolar cell polarity

EZR WNT5A LAMA1 MSN

3.26e-05291314GO:0061339
GeneOntologyBiologicalProcesspolarized epithelial cell differentiation

EZR WNT5A LAMA1 MSN

3.75e-05301314GO:0030859
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

CERS2 EZR TMEM67 RAP1GAP ARHGAP24 KALRN WNT5A RDX CORO1B ADCY6 NRP1 RHOG PLXNC1 TENM1 FGFR1 PLXNA1

9.38e-0584613116GO:0120035
GeneOntologyBiologicalProcesssalivary gland morphogenesis

LAMA1 NRP1 FGFR1 PLXNA1

9.70e-05381314GO:0007435
GeneOntologyBiologicalProcessregulation of cell projection organization

CERS2 EZR TMEM67 RAP1GAP ARHGAP24 KALRN WNT5A RDX CORO1B ADCY6 NRP1 RHOG PLXNC1 TENM1 FGFR1 PLXNA1

1.18e-0486313116GO:0031344
GeneOntologyBiologicalProcessestablishment of epithelial cell polarity

EZR WNT5A LAMA1 MSN

1.44e-04421314GO:0090162
GeneOntologyBiologicalProcesssalivary gland development

LAMA1 NRP1 FGFR1 PLXNA1

1.58e-04431314GO:0007431
GeneOntologyBiologicalProcessnegative regulation of vasoconstriction

DUSP5 MTNR1B NOS1

1.91e-04181313GO:0045906
GeneOntologyBiologicalProcessgland development

EZR RAP1GAP VWF KALRN WNT5A LAMA1 PRDX2 PTCH1 NRP1 MSN FGFR1 PLXNA1

2.33e-0455813112GO:0048732
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

DOCK2 RAP1GAP ARHGAP24 GARNL3 KALRN RDX ARHGEF11 NRP1 ARHGAP22

2.82e-043331319GO:0051056
GeneOntologyBiologicalProcessregulation of GTPase activity

RAP1GAP ARHGAP24 KALRN WNT5A RDX RHOG ARHGAP22 PLXNC1 PLXNA1

2.94e-043351319GO:0043087
GeneOntologyBiologicalProcesssynaptic signaling by nitric oxide

WNT5A NOS1

3.95e-0451312GO:0099163
GeneOntologyBiologicalProcessdichotomous subdivision of terminal units involved in salivary gland branching

NRP1 PLXNA1

3.95e-0451312GO:0060666
GeneOntologyBiologicalProcessregulation of organelle assembly

EZR TMEM67 WNT5A RDX ATG2A MSN NF2 FGFR1

4.28e-042801318GO:1902115
GeneOntologyBiologicalProcessexocrine system development

LAMA1 NRP1 FGFR1 PLXNA1

4.73e-04571314GO:0035272
GeneOntologyBiologicalProcessestablishment or maintenance of epithelial cell apical/basal polarity

EZR WNT5A LAMA1 MSN

5.06e-04581314GO:0045197
GeneOntologyCellularComponentsemaphorin receptor complex

NRP1 PLXNC1 PLXNA1

7.03e-05131343GO:0002116
GeneOntologyCellularComponenturopod

EZR MSN PIP5K1B

8.90e-05141343GO:0001931
GeneOntologyCellularComponentcell trailing edge

EZR MSN PIP5K1B

1.11e-04151343GO:0031254
GeneOntologyCellularComponentcell tip

EZR RDX MSN

1.64e-04171343GO:0051286
GeneOntologyCellularComponentglutamatergic synapse

CLSTN3 HTR4 KALRN WNT5A CORO1B GRM3 NRP1 RHOG ARHGAP22 PLXNC1 SCN8A KCNMA1 FGFR1 NOS1 PLXNA1

2.41e-0481713415GO:0098978
GeneOntologyCellularComponentcell pole

EZR RDX MSN

2.71e-04201343GO:0060187
GeneOntologyCellularComponentapical part of cell

EZR DYNC2H1 SLC2A7 SLC5A7 RDX PTCH1 PTH1R MSN NF2 KCNMA1 ATP12A CYBA

4.35e-0459213412GO:0045177
DomainERM_C_dom

EZR RDX MSN NF2

2.46e-0941334IPR011259
DomainERM

EZR RDX MSN NF2

2.46e-0941334PF00769
DomainERM

EZR RDX MSN NF2

2.46e-0941334IPR011174
DomainMoesin_tail

EZR RDX MSN NF2

8.46e-0871334IPR008954
DomainEz/rad/moesin-like

EZR RDX MSN NF2

1.34e-05211334IPR000798
DomainFERM_CS

EZR RDX MSN NF2

2.34e-05241334IPR019747
DomainFERM_C

EZR RDX MSN NF2

3.25e-05261334PF09380
DomainFERM_PH-like_C

EZR RDX MSN NF2

3.80e-05271334IPR018980
DomainFERM_C

EZR RDX MSN NF2

3.80e-05271334SM01196
DomainFERM_N

EZR RDX MSN NF2

8.57e-05331334IPR018979
DomainFERM_N

EZR RDX MSN NF2

8.57e-05331334PF09379
DomainDynein_heavy_chain_D4_dom

DYNC2H1 DNAH14 DNAH9

1.21e-04141333IPR024317
DomainDynein_HC_stalk

DYNC2H1 DNAH14 DNAH9

1.21e-04141333IPR024743
DomainATPase_dyneun-rel_AAA

DYNC2H1 MDN1 DNAH9

1.21e-04141333IPR011704
DomainMT

DYNC2H1 DNAH14 DNAH9

1.21e-04141333PF12777
DomainAAA_8

DYNC2H1 DNAH14 DNAH9

1.21e-04141333PF12780
DomainAAA_5

DYNC2H1 MDN1 DNAH9

1.21e-04141333PF07728
Domain-

STXBP5L WDR81 CORO1B CFAP43 PALB2 BRWD3 TECPR2 PLXNC1 CORO6 PLXNA1

1.38e-04333133102.130.10.10
DomainWD40/YVTN_repeat-like_dom

STXBP5L WDR81 CORO1B CFAP43 PALB2 BRWD3 TECPR2 PLXNC1 CORO6 PLXNA1

1.45e-0433513310IPR015943
DomainHomez_dom

ZHX3 HOMEZ

1.50e-0431332IPR024578
DomainHomez

ZHX3 HOMEZ

1.50e-0431332PF11569
DomainDHC_fam

DYNC2H1 DNAH14 DNAH9

1.51e-04151333IPR026983
DomainDynein_heavy

DYNC2H1 DNAH14 DNAH9

1.51e-04151333PF03028
DomainDynein_heavy_dom

DYNC2H1 DNAH14 DNAH9

1.51e-04151333IPR004273
DomainFERM_M

EZR RDX MSN NF2

3.18e-04461334PF00373
Domain-

EZR RDX MSN NF2

4.06e-044913341.20.80.10
DomainFERM_central

EZR RDX MSN NF2

4.06e-04491334IPR019748
DomainFERM_domain

EZR RDX MSN NF2

4.06e-04491334IPR000299
DomainFERM/acyl-CoA-bd_prot_3-hlx

EZR RDX MSN NF2

4.39e-04501334IPR014352
DomainFERM_1

EZR RDX MSN NF2

4.39e-04501334PS00660
DomainFERM_2

EZR RDX MSN NF2

4.39e-04501334PS00661
DomainFERM_3

EZR RDX MSN NF2

4.39e-04501334PS50057
DomainBand_41_domain

EZR RDX MSN NF2

4.39e-04501334IPR019749
DomainB41

EZR RDX MSN NF2

4.39e-04501334SM00295
Domain1-cysPrx_C

PRDX4 PRDX2

4.96e-0451332PF10417
DomainIP_trans

PITPNM2 PITPNC1

4.96e-0451332PF02121
DomainPeroxiredoxin_C

PRDX4 PRDX2

4.96e-0451332IPR019479
DomainPI_transfer

PITPNM2 PITPNC1

7.41e-0461332IPR001666
DomainWD_REPEATS_1

STXBP5L WDR81 CORO1B CFAP43 PALB2 BRWD3 TECPR2 CORO6

8.59e-042781338PS00678
DomainWD_REPEATS_2

STXBP5L WDR81 CORO1B CFAP43 PALB2 BRWD3 TECPR2 CORO6

8.79e-042791338PS50082
DomainWD_REPEATS_REGION

STXBP5L WDR81 CORO1B CFAP43 PALB2 BRWD3 TECPR2 CORO6

8.79e-042791338PS50294
DomainTrimer_CC

CORO1B CORO6

1.03e-0371332IPR015049
DomainDUF1899

CORO1B CORO6

1.03e-0371332IPR015048
DomainTrimer_CC

CORO1B CORO6

1.03e-0371332PF08954
DomainDUF1899

CORO1B CORO6

1.03e-0371332PF08953
DomainCoronin

CORO1B CORO6

1.03e-0371332IPR015505
DomainAhpC/TSA

PRDX4 PRDX2

1.03e-0371332IPR000866
DomainAhpC-TSA

PRDX4 PRDX2

1.03e-0371332PF00578
DomainDUF1899

CORO1B CORO6

1.03e-0371332SM01166
DomainWD40_repeat_dom

STXBP5L WDR81 CORO1B CFAP43 PALB2 BRWD3 TECPR2 CORO6

1.31e-032971338IPR017986
DomainDHC_N1

DYNC2H1 DNAH9

1.37e-0381332PF08385
DomainDynein_heavy_dom-1

DYNC2H1 DNAH9

1.37e-0381332IPR013594
DomainPlexin_cytopl

PLXNC1 PLXNA1

1.75e-0391332PF08337
DomainPatatin

PNPLA3 PNPLA7

1.75e-0391332PF01734
DomainPNPLA

PNPLA3 PNPLA7

1.75e-0391332PS51635
DomainPatatin/PLipase_A2-rel

PNPLA3 PNPLA7

1.75e-0391332IPR002641
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNC1 PLXNA1

1.75e-0391332IPR013548
DomainPlexin

PLXNC1 PLXNA1

1.75e-0391332IPR031148
DomainRap_GAP

RAP1GAP GARNL3

2.18e-03101332PF02145
DomainRap_GAP_dom

RAP1GAP GARNL3

2.65e-03111332IPR000331
DomainRAPGAP

RAP1GAP GARNL3

2.65e-03111332PS50085
DomainWD40

STXBP5L WDR81 CORO1B CFAP43 BRWD3 TECPR2 CORO6

3.11e-032681337SM00320
DomainC8

VWF FCGBP

3.17e-03121332PF08742
DomainTIL

VWF FCGBP

3.17e-03121332PF01826
DomainWD40_repeat

STXBP5L WDR81 CORO1B CFAP43 BRWD3 TECPR2 CORO6

3.37e-032721337IPR001680
DomainRho_GTPase_activation_prot

ARHGAP24 ARHGAP22 PLXNC1 PLXNA1

3.61e-03881334IPR008936
DomainUnchr_dom_Cys-rich

VWF FCGBP

3.73e-03131332IPR014853
DomainC8

VWF FCGBP

3.73e-03131332SM00832
DomainDynein_heavy_dom-2

DYNC2H1 DNAH9

4.33e-03141332IPR013602
DomainDHC_N2

DYNC2H1 DNAH9

4.33e-03141332PF08393
DomainTIL_dom

VWF FCGBP

4.33e-03141332IPR002919
DomainSEA

MUC3B MUC3A

4.33e-03141332SM00200
DomainVWF_type-D

VWF FCGBP

5.66e-03161332IPR001846
DomainVWFD

VWF FCGBP

5.66e-03161332PS51233
DomainVWD

VWF FCGBP

5.66e-03161332SM00216
DomainVWD

VWF FCGBP

5.66e-03161332PF00094
DomainHomeobox_KN

IRX4 HOMEZ

6.38e-03171332PF05920
DomainHomeobox_KN_domain

IRX4 HOMEZ

6.38e-03171332IPR008422
DomainAcyl_Trfase/lysoPLipase

PNPLA3 PNPLA7

6.38e-03171332IPR016035
DomainEGF

MUC3B LAMA1 FCGBP OIT3 TENM1 MUC3A

6.78e-032351336SM00181
Domain-

EZR ARHGAP24 KALRN RDX ARHGEF11 MSN ARHGAP22 NF2

6.97e-0339113382.30.29.30
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

EZR RAP1GAP KALRN RDX ARHGEF11 NRP1 MSN PLXNC1 FGFR1 PLXNA1

1.33e-052619810MM15676
PathwayREACTOME_L1CAM_INTERACTIONS

EZR LAMA1 RDX NRP1 MSN SCN8A FGFR1

2.09e-05121987M872
PathwayWP_PTDINS45P2_IN_CYTOKINESIS_PATHWAY

EZR RDX MSN

6.85e-0512983M45558
PathwayREACTOME_L1CAM_INTERACTIONS

EZR RDX NRP1 MSN FGFR1

1.08e-0468985MM14968
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

CUL2 EZR RAP1GAP KALRN LAMA1 RDX ARHGEF11 NRP1 MSN PLXNC1 SCN8A FGFR1 PLXNA1

1.68e-045759813M29853
Pubmed

Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition.

EZR RDX MSN NF2

2.17e-104135431018575
Pubmed

Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout.

EZR RDX MSN NF2

2.17e-10413549890997
Pubmed

Finding the Unicorn, a New Mouse Model of Midfacial Clefting.

EZR RDX PTCH1 MSN

2.69e-089135431940751
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

EZR ARHGAP24 KALRN WDR81 RDX CORO1B PRDX2 BCOR GRM3 ARHGEF11 VIRMA MSN LRPPRC MDN1 NAT10 KCNMA1 PRKCB NOS1

3.96e-089631351828671696
Pubmed

The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.

EZR RDX MSN

5.72e-08313538479753
Pubmed

Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins.

EZR RDX MSN

5.72e-083135318261459
Pubmed

Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.

EZR RDX MSN

5.72e-083135321659656
Pubmed

Expression, localization, and binding activity of the ezrin/radixin/moesin proteins in the mouse testis.

EZR RDX MSN

5.72e-083135319064715
Pubmed

Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.

EZR RDX MSN

5.72e-083135321864676
Pubmed

Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation.

EZR RDX MSN

5.72e-083135314613898
Pubmed

Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/Moesin.

EZR RDX MSN

5.72e-083135326555866
Pubmed

Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection.

EZR RDX MSN

5.72e-083135323703860
Pubmed

Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation.

EZR RDX MSN

5.72e-083135316889625
Pubmed

Effect of knockdown of ezrin, radixin, and moesin on P-glycoprotein function in HepG2 cells.

EZR RDX MSN

5.72e-083135321837648
Pubmed

Ezrin and moesin function together to promote T cell activation.

EZR RDX MSN

5.72e-083135319124745
Pubmed

Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.

EZR RDX MSN

5.72e-083135322132106
Pubmed

Ezrin-radixin-moesin family proteins are involved in parvovirus replication and spreading.

EZR RDX MSN

5.72e-083135319321616
Pubmed

Deciphering brain-specific transcriptomic expression of Ezr, Rad and Msn genes in the development of Mus musculus.

EZR RDX MSN

5.72e-083135329906485
Pubmed

Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM.

EZR RDX MSN

5.72e-083135331843195
Pubmed

Increased phosphorylation of ezrin/radixin/moesin proteins contributes to proliferation of rheumatoid fibroblast-like synoviocytes.

EZR RDX MSN

5.72e-083135321278069
Pubmed

Nuclear ERM (ezrin, radixin, moesin) proteins: regulation by cell density and nuclear import.

EZR RDX MSN

5.72e-083135315149851
Pubmed

ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.

EZR RDX MSN

5.72e-083135321352885
Pubmed

A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites.

EZR RDX MSN

5.72e-08313531429901
Pubmed

ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.

EZR RDX MSN

5.72e-083135332098334
Pubmed

Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infection.

EZR RDX MSN

5.72e-083135318295815
Pubmed

Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis.

EZR RDX MSN

5.72e-083135312360288
Pubmed

Dynamics and function of ERM proteins during cytokinesis in human cells.

EZR RDX MSN

5.72e-083135328889652
Pubmed

Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling.

EZR RDX MSN

5.72e-083135323116763
Pubmed

Induction of ezrin-radixin-moesin molecules after cryogenic traumatic brain injury of the mouse cortex.

EZR RDX MSN

5.72e-083135321451358
Pubmed

Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.

EZR RDX MSN

5.72e-083135320679347
Pubmed

Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells.

EZR RDX MSN

5.72e-083135312385025
Pubmed

Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?

EZR RDX MSN

5.72e-083135325286001
Pubmed

Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications.

EZR RDX MSN

5.72e-083135317977945
Pubmed

Ezrin/radixin/moesin proteins are high affinity targets for ADP-ribosylation by Pseudomonas aeruginosa ExoS.

EZR RDX MSN

5.72e-083135315252013
Pubmed

ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.

EZR RDX MSN

5.72e-083135332160548
Pubmed

The amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind advanced glycation end products, an interaction that may play a role in the development of diabetic complications.

EZR RDX MSN

5.72e-083135312734202
Pubmed

Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation.

WNT5A PTCH1 PTH1R WNT5B

1.51e-0713135412538525
Pubmed

CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.

EZR RDX MSN

2.28e-074135327793041
Pubmed

The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.

EZR RDX MSN

2.28e-074135315096511
Pubmed

NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins.

RDX MSN NF2

2.28e-07413539430655
Pubmed

Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus.

EZR RDX MSN

2.28e-074135317237445
Pubmed

Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering.

EZR RDX MSN

2.28e-074135315178693
Pubmed

Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and Ezrin-Radixin-Moesin (ERM) proteins.

EZR RDX MSN

2.28e-074135320660156
Pubmed

In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.

EZR RDX MSN

2.28e-074135319129194
Pubmed

Ezrin is a component of the HIV-1 virological presynapse and contributes to the inhibition of cell-cell fusion.

EZR RDX MSN

2.28e-074135324760896
Pubmed

Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.

EZR RDX MSN

2.28e-074135320855527
Pubmed

Functional binding interaction identified between the axonal CAM L1 and members of the ERM family.

EZR RDX MSN

2.28e-074135312070130
Pubmed

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

EZR RDX MSN

2.28e-074135319890007
Pubmed

The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins.

EZR RDX MSN

2.28e-074135328302370
Pubmed

Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network.

EZR RDX MSN

2.28e-074135322685202
Pubmed

CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation.

EZR RDX MSN

2.28e-074135321289089
Pubmed

The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes.

EZR RDX MSN

2.28e-074135321148287
Pubmed

Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cells.

EZR RDX MSN

2.28e-074135318941185
Pubmed

Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death.

EZR RDX MSN

2.28e-074135315818415
Pubmed

Proteomic profiling in pancreatic cancer with and without lymph node metastasis.

EZR RDX MSN

2.28e-074135319152423
Pubmed

LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.

EZR RDX MSN

2.28e-074135319255442
Pubmed

Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation.

EZR RDX MSN RHOG

4.97e-0717135420706633
Pubmed

Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice.

EZR RDX MSN

5.69e-07513539464455
Pubmed

Activated ERM protein plays a critical role in drug resistance of MOLT4 cells induced by CCL25.

EZR RDX MSN

5.69e-075135323326330
Pubmed

Regulation of NK cell trafficking by CD81.

EZR RDX MSN

5.69e-075135319830727
Pubmed

A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.

EZR RDX MSN

5.69e-075135323063725
Pubmed

Interplay between RAGE, CD44, and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells.

EZR RDX MSN

5.69e-075135321278261
Pubmed

Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein.

EZR RDX MSN

5.69e-075135322891241
Pubmed

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho.

EZR RDX MSN

5.69e-075135310806479
Pubmed

Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin.

EZR RDX MSN

5.69e-075135323019340
Pubmed

Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer).

EZR RDX MSN

5.69e-075135325575591
Pubmed

A novel role for BRCA1 in regulating breast cancer cell spreading and motility.

EZR RDX MSN

5.69e-075135321282464
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

ZHX3 WNT5A PTCH1 NRP1 WNT5B FGFR1 NOS1 PLXNA1 HOMEZ

6.53e-07251135929031500
Pubmed

Multiple mouse chromosomal loci for dynein-based motility.

DYNC2H1 WNT5A RBP3 DNAH14 DNAH9

1.10e-064713558812413
Pubmed

Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes.

EZR RDX MSN

1.13e-066135317515952
Pubmed

Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice.

EZR RDX MSN

1.13e-066135323229862
Pubmed

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2.

EZR RDX MSN

1.13e-06613539472040
Pubmed

Human immunodeficiency virus (HIV-1) Vpr induced downregulation of NHE1 induces alteration in intracellular pH and loss of ERM complex in target cells.

EZR RDX MSN

1.13e-066135317349711
Pubmed

Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.

EZR RDX MSN

1.13e-066135326209696
Pubmed

The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton.

RDX MSN NF2

1.13e-066135312226091
Pubmed

Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.

HTR4 GRM3 PALB2 MTR NOS1

1.84e-0652135519328558
Pubmed

Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress.

EZR RDX MSN

1.98e-067135322291017
Pubmed

MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.

EZR RDX MSN

1.98e-067135323264465
Pubmed

Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias.

WNT5A PTCH1 PTH1R WNT5B

3.04e-0626135430685387
Pubmed

VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1- and PKCε-dependent manner.

EZR RDX MSN

3.16e-068135324788249
Pubmed

Genetic link between renal birth defects and congenital heart disease.

TMEM67 DYNC2H1 WNT5A QRICH1

4.13e-0628135427002738
Pubmed

Radixin regulates cell migration and cell-cell adhesion through Rac1.

EZR RDX MSN

4.72e-069135322467863
Pubmed

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.

PTCH1 PTH1R FGFR1

6.73e-0610135316284117
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

EZR PITRM1 L3MBTL2 COPG1 DUSP5 SLC5A7 VIRMA PTH1R ARHGAP22 LRPPRC MDN1 TRIM17 NAT10 CORO6 PXYLP1 HOMEZ CYBA

6.84e-0612421351730973865
Pubmed

Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice.

EZR WNT5A RDX MSN

7.18e-0632135426184908
Pubmed

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival.

PTCH1 PTH1R NRP1

9.22e-0611135314722611
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PITPNM2 RAP1GAP HSP90B2P VWF KALRN RBP3 RDX CORO1B PRDX2 GRM3 ARHGEF11 VIRMA DHX9 LRPPRC SLC25A12 PRKCB CORO6 NOS1

1.13e-0514311351837142655
Pubmed

Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia.

PTCH1 PTH1R FGFR1

1.23e-0512135317660199
Pubmed

Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath.

EZR RDX MSN

1.23e-0512135318579745
Pubmed

Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/β-catenin signaling.

EZR RDX MSN

1.23e-0512135329361573
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

NRP1 PLXNC1 PLXNA1

1.23e-0512135321270798
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

THOC1 DOCK2 EZR ARHGAP24 COPG1 PRDX4 RDX PRDX2 ARHGEF11 VIRMA MSN RHOG ARHGAP22 SLC25A12

1.40e-059161351432203420
Pubmed

Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma.

EZR MSN

1.50e-052135225299115
Pubmed

Apical membrane segregation of phosphatidylinositol-4,5-bisphosphate influences parathyroid hormone 1 receptor compartmental signaling and localization via direct regulation of ezrin in LLC-PK1 cells.

EZR PTH1R

1.50e-052135221672629
Pubmed

NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin.

EZR NF2

1.50e-052135226483553
Pubmed

Ezrin and moesin expression within the developing human cerebrum and tuberous sclerosis-associated cortical tubers.

EZR MSN

1.50e-052135212111362
Pubmed

Localization and functional domains of the neurofibromatosis type II tumor suppressor, merlin.

RDX NF2

1.50e-05213529563848
Pubmed

Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology.

EZR RDX

1.50e-052135231382374
Pubmed

Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.

EZR MSN

1.50e-052135228624994
Pubmed

Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B.

MUC3B MUC3A

1.50e-052135210973822
InteractionL1CAM interactions

EZR RDX PTCH1 VIRMA NRP1 MSN FGFR1 PLXNA1

8.90e-09641328int:L1CAM
InteractionROCK1 interactions

CERS2 CUL2 EZR ARHGAP24 RDX VIRMA MSN RHOG FGFR1

4.96e-061921329int:ROCK1
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

EZR RDX MSN NF2

1.73e-045010141293
GeneFamilyPeroxiredoxins

PRDX4 PRDX2

4.57e-0461012953
GeneFamilyPhosphatidylinositol transfer proteins

PITPNM2 PITPNC1

4.57e-04610121151
GeneFamilyWD repeat domain containing|Coronins

CORO1B CORO6

6.37e-0471012495
GeneFamilyPlexins

PLXNC1 PLXNA1

1.08e-0391012683
GeneFamilyPatatin like phospholipase domain containing

PNPLA3 PNPLA7

1.35e-03101012466
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZHX3 HOMEZ

3.09e-03151012529
GeneFamilyWD repeat domain containing

STXBP5L WDR81 CORO1B CFAP43 BRWD3 CORO6

3.52e-032621016362
GeneFamilyDyneins, axonemal

DNAH14 DNAH9

3.98e-03171012536
GeneFamilyWnt family|Endogenous ligands

WNT5A WNT5B

4.97e-03191012360
GeneFamilyCD molecules|Mucins

MUC3B MUC3A

6.05e-03211012648
GeneFamilySolute carriers

SLC27A6 SLC2A7 SLC5A7 SLC30A2 SLC25A12 SLC41A1 SLC22A20P

6.68e-033951017752
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZHX3 ARHGAP24 LAMA1 CFAP43 DNAH14 NRP1 ARHGAP22 TENM1 FGFR1

5.69e-091871349c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellfacs-Heart-LA-24m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 EZR B4GALNT4 HLA-DOA DUSP5 PRKCB NOS1

1.12e-061771347a3f8c26d54e44688bbd678ac7ef55d8ad172617d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZHX3 LAMA1 CFAP43 DNAH14 NRP1 TENM1 FGFR1

1.55e-061861347f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZHX3 ARHGAP24 LAMA1 DNAH14 NRP1 TENM1 FGFR1

1.67e-061881347af740fa78542438fdff627ea1f74f4eee43316be
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PITPNM2 VWF KALRN DUSP5 PGM2L1 PITPNC1 FGFR1

1.85e-0619113472f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCellDendritic_Cells|World / lung cells shred on cell class, cell subclass, sample id

HLA-DOA VSIR RHOG FCGBP PLXNC1 PRKCB CYBA

1.99e-0619313477792eb6e247af2d7a8f80476f37dcd880922d625
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ARHGAP24 WNT5A VSIR KCNMA1 PIP5K1B SOAT1 CYBA

2.28e-06197134750f994e0d4e69019ec92e164edf3e4e951333766
ToppCellfacs-Heart-LV-24m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 EZR HLA-DOA DUSP5 PRKCB NOS1

1.16e-0516713464a669eafde3582a451614ad304769b47aa1d9578
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

CLSTN3 B4GALNT4 CAMK1G TRIM17 KCNMA1 CORO6

1.16e-0516713469efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

CLSTN3 B4GALNT4 CAMK1G TRIM17 KCNMA1 CORO6

1.16e-051671346904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCellfacs-Heart-LV-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 EZR HLA-DOA DUSP5 PRKCB NOS1

1.24e-051691346ae85cef7ef8f761c19f4af2a23fe333641c38a92
ToppCellfacs-Heart-LV-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 EZR HLA-DOA DUSP5 PRKCB NOS1

1.24e-051691346c01bc3f2f299109086ded83dc11e98559bf1940c
ToppCellControl-Endothelial_cells-Systemic_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

VWF ADAMTS4 KALRN SLC2A7 PITPNC1 NRP1

1.37e-051721346c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THOC1 DUSP5 PDCD2L PALB2 MDN1 MTR

1.51e-051751346bb058e714d21a0ec8532eaf3c7dd2faf78016bc0
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ZHX3 KALRN ST7 PAQR8 RDX CORO6

1.51e-05175134678a86cac3e6c0d115c997d1c29ee0e24af54551f
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THOC1 PDCD2L PALB2 MDN1 PRICKLE3 MTR

1.56e-0517613466b4afd2c9268172063fe5832896bea15e862579e
ToppCellfacs-Heart-LA-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 EZR HLA-DOA DUSP5 PRKCB NOS1

1.56e-051761346077f3fe5e3482ea3f639d789bd3d584161b36c02
ToppCellfacs-Heart-LA-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 EZR HLA-DOA DUSP5 PRKCB NOS1

1.56e-051761346fc2ba468677b19b55130c1f06737f40300cd9d2e
ToppCelldroplet-Lung|droplet / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1B VSIR MSN RHOG PRKCB CYBA

1.61e-051771346e1555e45880c04fcc89e1234e97897d27246250f
ToppCelldroplet-Lung|droplet / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CORO1B VSIR MSN RHOG PRKCB CYBA

1.61e-051771346dd35d534ba09237a37ac58cca184e5d84d3b36ac
ToppCellDendritic_Cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

VSIR RHOG CACNA2D4 PLXNC1 PRKCB CYBA

1.66e-05178134661ce3ec64c4cffceac08412e20c26e9c90ab8197
ToppCellCOVID-19-kidney-Stressed_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS4 KALRN DUSP5 PITPNC1 FGFR1 TMEM151A

1.72e-051791346754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PITPNM2 ADAMTS4 KALRN DUSP5 PITPNC1 FGFR1

2.07e-051851346673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCellDendritic_Cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

HLA-DOA VSIR FCGBP PLXNC1 PRKCB CYBA

2.47e-051911346b51c8ff1279581088557bb36760c70209c77148c
ToppCellCOVID-19-kidney-Myeloid|kidney / Disease (COVID-19 only), tissue and cell type

DOCK2 VSIR RHOG PLXNC1 PRKCB CYBA

2.55e-051921346441cd1ec171f643b28e1f6f9c04def629cc7391b
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ARHGAP24 VSIR RHOG ARHGAP22 FCGBP CYBA

2.55e-051921346314d94d676d13f4ca0eea8ba222c7eb00946849c
ToppCellCOVID-19-kidney-Myeloid|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK2 VSIR RHOG PLXNC1 PRKCB CYBA

2.55e-0519213460b9d22a222f1201e375f8e55cace9ef939febae4
ToppCellSmart-seq2-thymus_(Smart-seq2)-lymphocytic-B_lymphocytic-plasma_cell|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HSP90B2P PRDX4 DUSP5 SRM YIPF2 CYBA

2.62e-051931346bd82961502db42a0c862d3a29a2babe8032384c8
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK2 VSIR NRP1 ARHGAP22 KCNMA1 PRKCB

2.70e-051941346663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

VWF ADAMTS4 KALRN DUSP5 PITPNC1 FGFR1

2.78e-051951346a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

VWF ADAMTS4 KALRN DUSP5 PITPNC1 MSN

2.78e-051951346818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCellAdult-Immune-monocyte-D122|Adult / Lineage, Cell type, age group and donor

DOCK2 VSIR PLXNC1 KCNMA1 PRKCB CYBA

2.86e-05196134616b0acb6157534938ca83d4e909471e33a7d3c52
ToppCellSmart-seq2-thymus_(Smart-seq2)-lymphocytic-B_lymphocytic|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HSP90B2P PRDX4 DUSP5 SRM PRDX2 YIPF2

2.86e-05196134660cde394db9f1c39c258c3e7c01d3d1c76cc49a1
ToppCellmLN-T_cell-Treg|T_cell / Region, Cell class and subclass

ARHGAP24 PGM2L1 CORO1B PIP5K1B FGFR1 CCR8

2.94e-0519713463779489d57ebda33277c79cba037f4c73128c8ba
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 VSIR ARHGAP22 PLXNC1 KCNMA1 PRKCB

2.94e-0519713466ca6e17b7cc5f7ea8d4b6ca1ff670969bee65a45
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PCDHGB7 WNT5A PTH1R TRIM17 PAPPA FGFR1

2.94e-0519713462ca5ebb708935a90b12b8e98a22ae2d664ed002e
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN STXBP5L SCN8A KCNMA1 PRKCB CORO6

3.03e-051981346c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellTracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 HLA-DOA ARHGAP22 CACNA2D4 PLXNC1 PRKCB

3.03e-051981346d73585a5587941483db8d9ddc2d68f7d852bbbc8
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 ARHGAP22 PLXNC1 KCNMA1 PNPLA3 SOAT1

3.03e-0519813460b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VSIR RHOG CACNA2D4 PLXNC1 PRKCB CYBA

3.03e-0519813466d547122b8c4ddbdd0d3dae3bce4a125740d5457
ToppCellTracheal-NucSeq-Immune_Lymphocytic-B|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 DUSP5 WNT5B PLXNC1 PRKCB CYBA

3.11e-05199134658242d78517c05fa367a7c6edac57ef79107453c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK2 WDR81 CORO1B VSIR FCGBP CYBA

3.20e-05200134680e0483d5ab0c6213aae0ec62619f57e6ec0e4c2
ToppCellNeuronal-Inhibitory-iB|Neuronal / cells hierarchy compared to all cells using T-Statistic

BEST3 PITPNC1 TENM1 PIP5K1B PAPPA NOS1

3.20e-05200134645ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDCD2L ARHGAP22 UBA7 TMEM106C KCNMA1

4.97e-051321345a1fda8c5287168c4f159203ed27cadfb4ce1b131
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ARHGAP24 HTR4 SLC5A7 WNT5B NOS1

7.76e-05145134578f5f4b96420c7f391e4d32a9ed151ed95fad90b
ToppCellMS-CD4-CD8_2|MS / Condition, Cell_class and T cell subcluster

ST7 GRM3 PXYLP1 PNPLA7 IQCK

8.82e-05149134508fb6be5599c5988890c851ce5ac6781c319948e
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DOCK2 HTR4 WNT5A SLC5A7 WNT5B

8.82e-05149134598ae408d2d0347865875ff8bbd89d359decea526
ToppCellLPS-antiTNF-Stromal_mesenchymal-Fibroblasts-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNF25 CORO1B PTCH1 FASTKD3 SOAT1

9.39e-051511345f13a117ae26ae525da4f3e837d8f204d00dc6ee3
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAQR8 VSIR PRKCB HOMEZ CYBA

9.99e-0515313456a2a2379238133ce0ad714af130ffe02dd317247
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK2 HLA-DOA FCGBP KCNMA1 CYBA

9.99e-051531345099382241971412f84b6feefb897360a74a41143
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAQR8 VSIR PRKCB HOMEZ CYBA

9.99e-051531345faa442dd925b2b09919e93c492ccc3f19803ad24
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ARHGAP22 PIP5K1B CORO6 ATP12A NOS1

1.20e-0415913450dccc4275b9b4f8554dd556da7218e130bff8fd1
ToppCellmild_COVID-19_(asymptomatic)-B_cell|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

ARHGAP24 HLA-DOA DUSP19 PIP5K1B PAPPA

1.38e-041641345e4d43af7eb04d55328791b554bdf3a7ce6818027
ToppCellfacs-Heart-LA-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAP1GAP HLA-DOA SLC30A2 CACNA2D4 PRKCB

1.51e-0416713458ce8d93c79ac6a3f52252b4cec53378c362bfe0a
ToppCellfacs-Heart-LA-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAP1GAP HLA-DOA SLC30A2 CACNA2D4 PRKCB

1.51e-0416713458340f7075d00dccb304cfd4c9b5711ca6dbf7cce
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)|Hippocampus / BrainAtlas - Mouse McCarroll V32

HTR4 KALRN DUSP5 PGM2L1 PRKCB

1.55e-0416813456db453cbbbaf4144a86fadcfa5805d33396713b5
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ARHGAP24 HTR4 WNT5A SLC5A7 WNT5B

1.64e-04170134514aa86a4f526ed6986afcb28c49225522055550c
ToppCellCOVID-19-kidney-Plasma|kidney / Disease (COVID-19 only), tissue and cell type

DOCK2 WNT5B PLXNC1 PIP5K1B PRKCB

1.68e-041711345a59a054b8e119215f24dc5c80ad5a8094b3500f9
ToppCelldroplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EZR HIPK4 WNT5A LAMA1 FCGBP

1.73e-041721345c0bda7153e02bee7d0326138cc684151c404c2a1
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM67 GARNL3 DHX9 PRKCB SLC41A1

1.73e-0417213453f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-migDC|lymph-node_spleen / Manually curated celltypes from each tissue

WNT5A CAMK1G WNT5B ARHGAP22 NOS1

1.73e-0417213451b24bed3cd8e3fa463c5e7cefdf9e99e639e2f84
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_10|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

WNT5A WNT5B ARHGAP22 KCNMA1 NOS1

1.77e-04173134509a13407a41ff2cba82fc417b72bf9a24ce6c42e
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_10|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

WNT5A WNT5B ARHGAP22 KCNMA1 NOS1

1.77e-041731345bfec038a6783f166240da4861e100643c6ea80a5
ToppCell3'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells-CLP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HLA-DOA PGM2L1 PRKCB ZCCHC7 ZBTB11

1.77e-041731345b367b62309389e8b6a65de83c2434dc8ec905985
ToppCelldroplet-Lung-30m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HLA-DOA CFAP43 WNT5B ARHGAP22 FGFR1

1.77e-041731345b6aed736d8480e3a6a5718aabd2fb79b1b75fa48
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZHX3 KALRN ST7 RDX CORO6

1.82e-041741345a1f745962a104c6f4b86b7e482da8755384c773a
ToppCelldroplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BCOR UBA7 OIT3 PIP5K1B IQCK

1.82e-041741345e9e4532a474b4b0938a50ff85c9508aca53cd3ae
ToppCellCOVID-19-kidney-REN+Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

KALRN CAMK1G PITPNC1 PTH1R PIP5K1B

1.82e-0417413458393f0b43c767839c1630bcb952d62b42efc788d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR4 DNAH14 NRP1 ARHGAP22 PNPLA7

1.82e-0417413457d4b860e05b5931f6f9d757a68f75ff35597a47a
ToppCelldroplet-Lung-nan-18m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY6 AXIN1 DHX9 ARHGAP22 UBA7

1.92e-04176134524b2e94ee5defcefb64a1f2447a2cc71b015b0fd
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

OR4K2 PITPNC1 TENM1 PIP5K1B NOS1

1.92e-041761345322259a35f5c97d73ce7f75835dcdb5c954c91f8
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HTR4 WNT5A SLC5A7 WNT5B NOS1

1.92e-04176134505ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCell5'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAP1GAP HTR4 DNAH14 FCGBP PLXNA1

1.97e-041771345e1e45956887371b1c18f1eb479dd930031497520
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Neutrophil|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 B4GALNT4 VSIR PLXNC1 PRKCB

1.97e-041771345ed44b1bf2ffae97f94e944d1b6060d5163eba6a6
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZHX3 CAMK1G PLXNC1 POLL PLXNA1

2.03e-041781345c87945146b2734141f07b39d268e0d8086ee0364
ToppCelldroplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Hematologic-hematopoietic_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NTAQ1 PITPNC1 VSIR MSN PRKCB

2.08e-041791345cb880ef40c203c8bd16c4f69a70cf59f97ebbffd
ToppCelldroplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Hematologic|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NTAQ1 PITPNC1 VSIR MSN PRKCB

2.08e-041791345686b9f745d290ca686b42d9505e9792c78667e6e
ToppCelldroplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Hematologic-hematopoietic_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NTAQ1 PITPNC1 VSIR MSN PRKCB

2.08e-0417913451eb004e1a17e1f1e4337e0581e547c0f5a965e68
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM67 DYNC2H1 WDR81 WNT5B PAPPA

2.08e-041791345a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 HLA-DOA VSIR MSN CYBA

2.13e-04180134583f9060dcf1d0ff8d2b2edc1841b2624b81c0eb3
ToppCellCOVID-19-kidney-PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PITPNM2 KALRN DUSP5 PITPNC1 FGFR1

2.13e-041801345493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCellfacs-SCAT-Fat-24m-Lymphocytic-nan|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EZR HLA-DOA DUSP5 PRKCB NOS1

2.13e-04180134586cdb1652f1736c38b501f07cf40ce99134cf597
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DOCK2 EZR HLA-DOA PRKCB CYBA

2.13e-041801345b83d067dee641941c596e4a25d81327931b6ad61
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

NBPF3 PRDX4 KCNMA1 PIP5K1B INTS9

2.13e-0418013458e96f8646c002768b272359af485dc0ab57e0ccd
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF ADAMTS4 RDX PITPNC1 NRP1

2.13e-041801345efc4c5a4dea456527526bbfd88cf70d803893671
ToppCellfacs-SCAT-Fat-24m-Lymphocytic|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EZR HLA-DOA DUSP5 PRKCB NOS1

2.13e-041801345115ce9f048f933704a19759948dcc933245e63c4
ToppCellVE-matDC|VE / Condition, Cell_class and T cell subcluster

WNT5A DUSP5 CAMK1G WNT5B ARHGAP22

2.19e-041811345982fd96ef75bc9ab2c2f4970c01b76ba7a164871
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS4 WNT5A PTCH1 CORO6 PNPLA7

2.19e-041811345b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellVE-matDC-|VE / Condition, Cell_class and T cell subcluster

WNT5A DUSP5 CAMK1G WNT5B ARHGAP22

2.19e-0418113456252184ef098b911df50be4fe1b5565849a5b6b8
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 WNT5B PLXNC1 PIP5K1B PRKCB

2.19e-0418113455a4fe0eca7cbc9cbc8a2fdbe795a7c5f4052a659
ToppCellfacs-SCAT-Fat-24m-Lymphocytic-B_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EZR HLA-DOA DUSP5 PRKCB NOS1

2.19e-04181134514faef1dde781d501834379f2a6413e8d6a80b72
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DOCK2 EZR HLA-DOA PRKCB CYBA

2.19e-041811345d909821355f4bc9e35387cda6ecf7c56793d9da4
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DOCK2 EZR HLA-DOA PRKCB CYBA

2.19e-04181134552935c496b45207a173b5ac7812f46210c3f74b0
ToppCellfacs-Trachea-18m-Hematologic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK2 DUSP5 RHOG PRKCB CYBA

2.25e-041821345a72b200488d212f1783233a94fc9a9596269f284
ToppCellfacs-Spleen-nan-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGEE2 PITPNC1 VSIR NRP1 CCR8

2.25e-041821345fbe5bdd642b86010dbef0a567b25c69c7335688f
ToppCellASK454-Epithelial|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

PCDHGB7 RDX CFAP43 PLXNA1 IQCK

2.25e-041821345ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 HLA-DOA VSIR MSN CYBA

2.25e-041821345cf32603ad9b9882b0bb873327d58b50dd26a5bd3
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS4 NRP1 ARHGAP22 PLXNC1 CYBA

2.25e-0418213454a85429d365c4b2d73fc921f261b4b7635ac40bd
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS4 NRP1 ARHGAP22 PLXNC1 CYBA

2.25e-04182134553213af34af3337f5edc734d3b7b79e4349eac0d
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ARHGAP24 VSIR FCGBP PIP5K1B CYBA

2.25e-041821345c6b3762ccec326f057819f75fa7fac0145fb7d54
Diseaseepilepsy (implicated_via_orthology)

KALRN DHX9 RHOG PRICKLE3 SCN8A KCNMA1 ATP12A NOS1

7.10e-071631318DOID:1826 (implicated_via_orthology)
DiseaseMedulloblastoma

L3MBTL2 PTCH1 PALB2 AXIN1

7.29e-05501314C0025149
DiseaseGrand Mal Status Epilepticus

SCN8A KCNMA1 CCR8 NOS1

2.29e-04671314C0311335
DiseaseStatus Epilepticus, Subclinical

SCN8A KCNMA1 CCR8 NOS1

2.29e-04671314C0751522
DiseaseSimple Partial Status Epilepticus

SCN8A KCNMA1 CCR8 NOS1

2.29e-04671314C0751524
DiseaseNon-Convulsive Status Epilepticus

SCN8A KCNMA1 CCR8 NOS1

2.29e-04671314C0751523
DiseasePetit mal status

SCN8A KCNMA1 CCR8 NOS1

2.29e-04671314C0270823
DiseaseComplex Partial Status Epilepticus

SCN8A KCNMA1 CCR8 NOS1

2.29e-04671314C0393734
DiseaseStatus Epilepticus

SCN8A KCNMA1 CCR8 NOS1

2.42e-04681314C0038220
Diseaseresponse to ranibizumab

PLXNC1 KCNMA1

2.90e-0461312EFO_0008348
DiseaseMalignant neoplasm of breast

RAP1GAP VWF KALRN DYNC2H1 PALB2 NF2 PRICKLE3 TENM1 MTR ACCS FGFR1 FASTKD3 DNAH9 PADI3

3.09e-04107413114C0006142
DiseaseDisproportionate short stature

DYNC2H1 WNT5A PTH1R FGFR1

3.91e-04771314C0878659
Diseasefocal segmental glomerulosclerosis (is_marker_for)

RAP1GAP VWF

5.38e-0481312DOID:1312 (is_marker_for)
Diseasemesangial proliferative glomerulonephritis (biomarker_via_orthology)

VWF FGFR1

5.38e-0481312DOID:4783 (biomarker_via_orthology)
Diseaseacoustic neuroma (is_marker_for)

NF2 FGFR1

6.90e-0491312DOID:12689 (is_marker_for)
DiseaseCleft upper lip

PTCH1 MTR FGFR1

6.95e-04391313C0008924
DiseaseHoloprosencephaly sequence

PTCH1 FGFR1

8.60e-04101312cv:C0079541
DiseaseCleft palate, isolated

PTCH1 MTR FGFR1

8.65e-04421313C1837218
Diseaseneuroticism measurement, cognitive function measurement

HTR4 L3MBTL2 KALRN PTCH1 GRM3 NRP1 NF2 TMEM151A NOS1

9.85e-045661319EFO_0007660, EFO_0008354
DiseasePancreatic Neoplasm

RAP1GAP PTCH1 PALB2 NRP1

1.05e-031001314C0030297
Diseaseblood phosphate measurement

NBPF3 PITPNM2 ZHX3 RAP1GAP PIP5K1B

1.10e-031741315EFO_0010972
DiseaseMalignant neoplasm of pancreas

RAP1GAP PTCH1 PALB2 NRP1

1.13e-031021314C0346647
Diseasecortisol measurement, response to corticosteroid, response to synacthen

ELSPBP1 NOS1

1.48e-03131312EFO_0005843, EFO_0009175, GO_0031960
DiseaseNephronophthisis

TMEM67 SLC41A1

1.48e-03131312C0687120
DiseaseRS-10-hydroxywarfarin to RS-warfarin ratio measurement

MUC3B GCFC2 CAMK1G MUC3A

1.49e-031101314EFO_0803335
Diseasepulmonary function measurement, FEV/FEC ratio

HTR4 PITPNC1 PTCH1

1.70e-03531313EFO_0003892, EFO_0004713
Diseaseglycerol-3-phosphate measurement

NBPF3 CFAP43

1.98e-03151312EFO_0010488
Diseasetriglycerides to total lipids in chylomicrons and extremely large VLDL percentage

PCIF1 PNPLA3

1.98e-03151312EFO_0022328
Diseasespine bone mineral density

PTCH1 AXIN1 WNT5B KCNMA1

1.99e-031191314EFO_0007701
Diseasecalcium measurement

NBPF3 PITPNM2 STXBP5L WDR81 FRK PRICKLE3 PIP5K1B FGFR1 NOS1

2.01e-036281319EFO_0004838
DiseaseLobar Holoprosencephaly

PTCH1 FGFR1

2.25e-03161312C0431362
DiseaseSemilobar Holoprosencephaly

PTCH1 FGFR1

2.25e-03161312C0751617
Diseasephosphorus measurement

NBPF3 RAP1GAP

2.25e-03161312EFO_0004861
Diseasetriacylglycerol 56:9 measurement

BCOR PRKCB

2.55e-03171312EFO_0010436
Diseasecholesterol to total lipids in chylomicrons and extremely large VLDL percentage

PCIF1 PNPLA3

2.55e-03171312EFO_0022232
Diseasebipolar disorder (is_marker_for)

RAP1GAP VWF

3.18e-03191312DOID:3312 (is_marker_for)
Diseasecarotid artery disease (is_marker_for)

VWF PAPPA

3.18e-03191312DOID:3407 (is_marker_for)
Diseasephospholipids:total lipids ratio, intermediate density lipoprotein measurement

CERS2 PCIF1 PNPLA3

3.33e-03671313EFO_0008595, EFO_0020946
DiseaseAdenocarcinoma of prostate

PALB2 AXIN1

3.53e-03201312C0007112
DiseaseNon-alcoholic Fatty Liver Disease

LAMA1 RDX PNPLA3

3.77e-03701313C0400966
DiseaseNonalcoholic Steatohepatitis

LAMA1 RDX PNPLA3

3.77e-03701313C3241937
DiseaseInfiltrating duct carcinoma of female breast

CAMK1G FGFR1

3.89e-03211312C3165106
Diseaseosteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty

PTCH1 KCNMA1

3.89e-03211312EFO_0004616, EFO_0010726, EFO_1000786
Diseasefree cholesterol to total lipids in chylomicrons and extremely large VLDL percentage

PCIF1 PNPLA3

3.89e-03211312EFO_0022277
Diseasecholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage

PCIF1 PNPLA3

3.89e-03211312EFO_0022246
Diseaseobesity (biomarker_via_orthology)

PRKCB PNPLA3 FGFR1 NOS1

4.25e-031471314DOID:9970 (biomarker_via_orthology)
Diseaseotitis media (implicated_via_orthology)

NF2 FGFR1

4.26e-03221312DOID:10754 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
YSEFTLKCPICIYVP

PNAS-138

21

Q9BZS9
PYTLAAADYCIPSFL

BEST3

346

Q8N1M1
CSQVPYICSYLLPEE

CFAP43

606

Q8NDM7
CYYEILTPNTPFLID

CLSTN3

181

Q9BQT9
LCEAGEAFLIPTPYY

ACCS

181

Q96QU6
YEAPVLFRTEDYFPC

BLOC1S4

196

Q9NUP1
CPVFFVYIAYTLLPI

ADCY6

241

O43306
CIPCEPYEYLADEFT

GRM3

531

Q14832
DPSPLLFYLCAEVYQ

ARHGEF11

336

O15085
LLPFYDPDTSVVYVC

CORO1B

271

Q9BR76
FAVPVDLSAYPLYCT

BRWD3

1166

Q6RI45
DLSAYPLYCTVVAYP

BRWD3

1171

Q6RI45
VFEFEFSETPLLPCY

BCOR

1636

Q6W2J9
HCTLVYPLELYPAFF

CERS2

286

Q96G23
LFSCSVDYRPLYLPV

ATG2A

1116

Q2TAZ0
IIVVPYSEFACALLY

POLL

491

Q9UGP5
EPYDPDVLYYIFLCI

QRICH1

541

Q2TAL8
CSPKEYLETFIFPVL

IQCK

126

Q8N0W5
LVPCYPSGVIYDLLE

INTS9

296

Q9NV88
PVYCPVYESRLLATA

IRX4

46

P78413
YPTLCEPIRYSIPEE

PCDHGB7

26

Q9Y5F8
YCPPETAVLLASYAV

RDX

116

P35241
YLTEPVVEYCIQALP

HSP90B2P

206

Q58FF3
LSEEYTFYPDAVSPL

MDN1

3386

Q9NU22
EPICYPSLYEEVLGE

MAGEA9

296

P43362
ECRPLSYSNPVEYEL

MAGEE2

451

Q8TD90
CTKRYVITNPPYEFE

KCNMA1

1151

Q12791
PYEFELVPTDLIFCL

KCNMA1

1161

Q12791
PELSYLGIICVFAYI

SLC2A7

376

Q6PXP3
TPVVAAEDGTPYYCL

HIPK4

381

Q8NE63
LPVLCPDYLSYYTTI

KRT39

136

Q6A163
PTFRKIYCDAVPYLF

L3MBTL2

401

Q969R5
CHLYLPADEFPETYS

ATP12A

571

P54707
SLALADLVVAFYPYP

MTNR1B

81

P49286
YSIVAGVFVCLLEYP

CYBA

41

P13498
CVDDPKFYSYVEFPI

PLXNA1

286

Q9UIW2
YLAVAATYVLPEPET

PLXNC1

176

O60486
CEFPRLYTISEGYVP

OIT3

356

Q8WWZ8
PYEVDSFFCDLPVVF

OR4K2

171

Q8NGD2
PPTVLVYSATTECVY

MUC3A

116

Q02505
ISKTSYFLCYEPPTI

PGM2L1

486

Q6PCE3
YFLCYEPPTIKSIFE

PGM2L1

491

Q6PCE3
GLPLFLPYYICVADE

PDCD2L

181

Q9BRP1
KPDDYLYSICSEPLI

PIP5K1B

101

O14986
TITVSPFYGEYDICP

PNPLA3

181

Q9NST1
YLVIEDLSPGCPYQF

KALRN

2626

O60229
HPDQETYTDYVIPCF

LRPPRC

471

P42704
YCPPETAVLLASYAV

MSN

116

P26038
FCGTPDYIAPEIIAY

PRKCB

501

P05771
CYLELEFLYPLVPES

PAPPA

781

Q13219
EPLPLAYAVLYLTCV

PADI3

101

Q9ULW8
IDYALYCPDALTAFP

PITPNM2

921

Q9BZ72
FFYPLDFTFVCPTEI

PRDX2

41

P32119
VSGCPLPEACELYYV

NAT10

496

Q9H0A0
VVKSSDYCEYLRPPI

PNPLA7

1161

Q6ZV29
ILLCGYPPFYEETES

CAMK1G

211

Q96NX5
IYCPPEASVLLASYA

NF2

131

P35240
PPCTIFQAFKYYLDI

NOS1

1091

P29475
CTVPEGLLFPAEYYV

PALB2

396

Q86YC2
KYPNSLECTYIVFVP

NRP1

166

O14786
YQFFSCLPEDKVPYV

PRICKLE3

106

O43900
LVSAYFFSCPVPEKY

PAQR8

256

Q8TEZ7
YLELPDLCQPYRSDF

NBPF3

431

Q9H094
PVIPYAKYEDFLSCA

ARHGAP24

221

Q8N264
YLEPYLPCLSTEADK

FRK

11

P42685
YSPDECISLPVYTSA

DYNC2H1

4261

Q8NCM8
YYVLEPRVVDGTPCS

ADAMTS4

631

O75173
EVEAPEVEPRLVYCY

PCIF1

391

Q9H4Z3
YLPFVPSAEDVYDCQ

HLA-DOA

176

P06340
SQLLYEFYTCIPPVK

DOCK2

816

Q92608
FPDSYYEAFISLCIP

GCFC2

481

P16383
SPLYLEIIIYCTGAF

FGFR1

371

P11362
IPDVAAYCPAYVVKS

FCGBP

336

Q9Y6R7
CDTEYPVFVYQPAIR

CACNA2D4

1011

Q7Z3S7
YYPDIFSSPCDAELI

CCR8

16

P51685
DSIVVAYYFCGEPIP

AXIN1

781

O15169
DIYALCVAYPEPLGE

CUL2

41

Q13617
PYAITCSVVAFYIPF

HTR4

191

Q13639
LPFYDPDSSIVYLCG

CORO6

271

Q6QEF8
ELYAFECPVYQTPER

DNAH14

3451

Q0VDD8
TVPLLSFPDCYIAEF

MARF1

1021

Q9Y4F3
CQSEDYPRCIFPFIY

ELSPBP1

66

Q96BH3
AYEVLCYVPARSLPY

COPG1

686

Q9Y678
YCPPETAVLLGSYAV

EZR

116

P15311
IPADCPKEIYEHYFV

DNAH9

2361

Q9NYC9
YFPYPSLADIALLCL

HOMEZ

76

Q8IX15
ICVYLFTGELYPTEI

SLC22A20P

441

A6NK97
TFYSEYPECCVDVKP

DUSP5

131

Q16690
YDLDTVLPFPCLFDT

NTAQ1

96

Q96HA8
VLPFPCLFDTYVEDA

NTAQ1

101

Q96HA8
QAPYAIVCAFPYLLA

GARNL3

751

Q5VVW2
FNCPIIEVYGRTYPV

DHX9

556

Q08211
LIDFPTPIFYDVYLE

TMEM67

386

Q5HYA8
IFCVYLQPPSTYAVK

OR1L8

256

Q8NGR8
PPTVLVYSATTECVY

MUC3B

116

Q9H195
PIVLQYLCPVYISFF

SLC5A7

321

Q9GZV3
PFSYVYFFCTVPEIL

TMEM106C

196

Q9BVX2
PCFLAVLIDPYLDYS

TAAR3P

271

Q9P1P4
EYALAVCLSFFYPVL

SOAT1

461

P35610
YPLDFTFVCPTEIIA

PRDX4

116

Q13162
ICYTTNAFPKEYIPT

RHOG

21

P84095
PKVLTPYCYTIDVEI

FASTKD3

556

Q14CZ7
PPTYRADDEVICTSY

LAMA1

171

P25391
TEPYYCLSDFIAPLH

MTR

1076

Q99707
FPVNYVGECIRTVPY

PITRM1

861

Q5JRX3
EYLYPCLIITPLDCF

PTCH1

221

Q13635
CEDVNVDRFYPVLYP

RAP1GAP

161

P47736
YIFEYDQPDCLLSVT

TENM1

1901

Q9UKZ4
YIYPLVCAFFVALLP

SLC41A1

286

Q8IVJ1
PVTDPVYEALLYCNI

PXYLP1

56

Q8TE99
PCYEDALYFPVLIVH

TMEM151A

441

Q8N4L1
HLFYPYPICTETADR

ST7

481

Q9NRC1
YAIVTPSLNPFIYCL

OR6B1

276

O95007
AYFADCPPDLILVLY

STXBP5L

416

Q9Y2K9
PVVPFARYEDFLSCA

ARHGAP22

241

Q7Z5H3
SLENVLEPCAYAPTY

B4GALNT4

336

Q76KP1
LEPCAYAPTYVVKDF

B4GALNT4

341

Q76KP1
DIPFSAIYFPVYAHC

SLC25A12

491

O75746
ERPYVCPVCSEAYID

ZBTB11

911

O95625
TAIPLLCSYFFEAEP

RBP3

791

P10745
DPEPYLDVCIYDTCS

VWF

1076

P04275
SEDAPYPVCTVRYFP

UBA7

591

P41226
VVAVPCPDYIYDFNH

PTH1R

126

Q03431
YVCFTLVLQVPAEYP

RNF25

61

Q96BH1
AAFKVATPYSLYVCP

VSIR

31

Q9H7M9
PYTITEYTCSFLPKF

PITPNC1

91

Q9UKF7
EDLVYVDPSPDYCLR

WNT5B

276

Q9H1J7
LVAVPLEDFDPYYLT

SCN8A

76

Q9UQD0
EPVTFREFCPLYYLL

TECPR2

6

O15040
TQDLVYIDPSPDYCV

WNT5A

296

P41221
SLFPVVAYAYCTIPT

SRM

226

P19623
DVVPDATSAYPYLLL

TRIM17

296

Q9Y577
REVYDPSPVSPFICY

ZCCHC7

366

Q8N3Z6
ETVCIYGYSLFVFIP

YIPF2

201

Q9BWQ6
VYEQVVTFLPAYACP

SLC27A6

541

Q9Y2P4
FPYPTKAELCYLTVV

ZHX3

326

Q9H4I2
VPLLYFSCPYKTTFE

VIRMA

346

Q69YN4
YTIYVPFSCLLGDII

WDR81

1486

Q562E7
EAPTTCSIPIDYNLY

THOC1

221

Q96FV9
PEYKYVDPICTFVFS

SLC30A2

196

Q9BRI3
PETNILSYFPECFEF

DUSP19

121

Q8WTR2