Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	TDG MBD4	1.59e-05	2	80	2	GO:0008263
GeneOntologyMolecularFunction	mismatch base pair DNA N-glycosylase activity	TDG MBD4	9.46e-05	4	80	2	GO:0000700
Domain	Ago_hook	TNRC6A TNRC6B	5.15e-05	3	78	2	PF10427
Domain	TNRC6_PABC-bd	TNRC6A TNRC6B	5.15e-05	3	78	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6A TNRC6B	5.15e-05	3	78	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6A TNRC6B	5.15e-05	3	78	2	PF16608
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6A TNRC6B	2.22e-04	6	55	2	MM15083
Pathway	WP_BASE_EXCISION_REPAIR	PARP2 TDG MBD4	2.34e-04	31	55	3	M39861
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6A TNRC6B	3.10e-04	7	55	2	M46421
Pathway	KEGG_BASE_EXCISION_REPAIR	PARP2 TDG MBD4	3.37e-04	35	55	3	M5500
Pathway	REACTOME_CLEAVAGE_OF_THE_DAMAGED_PYRIMIDINE	TDG MBD4	4.12e-04	8	55	2	MM14478
Pathway	KEGG_MEDICUS_REFERENCE_BASE_EXCISION_AND_STRAND_CLEAVAGE_BY_MONOFUNCTIONAL_GLYCOSYLASE	TDG MBD4	4.12e-04	8	55	2	M47828
Pathway	REACTOME_RESOLUTION_OF_ABASIC_SITES_AP_SITES	PARP2 TDG MBD4	4.30e-04	38	55	3	M27701
Pathway	REACTOME_RESOLUTION_OF_ABASIC_SITES_AP_SITES	PARP2 TDG MBD4	4.65e-04	39	55	3	MM17222
Pathway	REACTOME_DISPLACEMENT_OF_DNA_GLYCOSYLASE_BY_APEX1	TDG MBD4	5.29e-04	9	55	2	MM14479
Pathway	REACTOME_DISPLACEMENT_OF_DNA_GLYCOSYLASE_BY_APEX1	TDG MBD4	5.29e-04	9	55	2	M26900
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	TNRC6A TNRC6B	5.29e-04	9	55	2	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	TNRC6A TNRC6B	5.29e-04	9	55	2	M46436
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	TNRC6A TNRC6B	6.59e-04	10	55	2	M48013
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	TNRC6A TNRC6B	1.13e-03	13	55	2	M46434
Pathway	WP_DNA_REPAIR_PATHWAYS_FULL_NETWORK	PARP2 TDG MBD4 FAAP100	1.22e-03	120	55	4	M40049
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TLN1 TNRC6B NFASC CACNA1G WDFY3 PPFIA3 BIRC6 GCN1	7.74e-08	225	84	8	12168954
Pubmed	Role of GW182 protein in the cell.	TNRC6A TNRC6B	5.76e-06	2	84	2	29791863
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6A TNRC6B	1.73e-05	3	84	2	34108231
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6A TNRC6B	1.73e-05	3	84	2	16880270
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6A TNRC6B	1.73e-05	3	84	2	31670606
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ORC4 BUB1 TNRC6A WRNIP1 TNRC6B YTHDC2	2.76e-05	242	84	6	34011540
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6A TNRC6B	3.45e-05	4	84	2	21063388
Pubmed	Genetic causes of Parkinson's disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR.	LRRK2 QDPR	3.45e-05	4	84	2	27613114
Pubmed	Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding.	MYOCD TDG	5.74e-05	5	84	2	18945672
Pubmed	Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population.	TDG MBD4	5.74e-05	5	84	2	19403629
Pubmed	A quantitative model of human DNA base excision repair. I. Mechanistic insights.	TDG MBD4	5.74e-05	5	84	2	11937636
Pubmed	Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA.	TDG MBD4	5.74e-05	5	84	2	18452947
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	TNRC6A TNRC6B	1.20e-04	7	84	2	19470757
Pubmed	Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway.	TDG MBD4	1.20e-04	7	84	2	20595612
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	TNRC6A TNRC6B	1.20e-04	7	84	2	19383768
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	CCT5 TLN1 TNRC6A TNRC6B	1.35e-04	107	84	4	30995489
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	DIP2B TNRC6A TNRC6B PPFIA3 QDPR	1.91e-04	218	84	5	33378226
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	CCT5 TLN1 GCN1 OBI1	2.04e-04	119	84	4	35776542
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CRYBG2 KLHL25 SLC2A4RG CDC42BPA TLN1 WDFY3 GTF2IRD1 FAAP100 BIRC6 GCN1	3.31e-04	1105	84	10	35748872
Pubmed	Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse.	SERPINB8 WRNIP1	4.42e-04	13	84	2	11863365
Pubmed	Alternative splice variants encoding unstable protein domains exist in the human brain.	FAT2 NFASC	4.42e-04	13	84	2	15491607
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	PDE3B TNRC6A TNRC6B YTHDC2 GCN1	4.52e-04	263	84	5	34702444
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	TNRC6A TNRC6B	5.15e-04	14	84	2	19716330
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	ORC4 CCT5 TLN1 BUB1 WRNIP1 YTHDC2 GCN1	5.28e-04	582	84	7	20467437
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	BUB1 TNRC6A TNRC6B BIRC6 GCN1 OBI1	5.37e-04	418	84	6	34709266
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CDC42BPA TENM3 CCT5 LRRK2 TNRC6A TNRC6B BIRC6 GCN1	5.86e-04	777	84	8	35844135
Pubmed	Detection of differentially expressed genes in the early developmental stage of the mouse mandible.	CCT5 FRG1	5.93e-04	15	84	2	11461004
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	TNRC6A TNRC6B	5.93e-04	15	84	2	21981923
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	OXER1 TIGD2 TENM3 WDFY3 ASIC4 PSD4	7.18e-04	442	84	6	15815621
Pubmed	Variation within DNA repair pathway genes and risk of multiple sclerosis.	PARP2 TDG MBD4	7.19e-04	72	84	3	20522537
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	TNRC6A TNRC6B YTHDC2 GCN1	7.67e-04	169	84	4	31462741
Pubmed	Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.	NFASC CACNA1G	8.60e-04	18	84	2	31910261
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	TNRC6A TNRC6B YTHDC2	9.76e-04	80	84	3	35803934
Pubmed	A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors.	TENM3 NFASC	1.06e-03	20	84	2	35224516
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DIP2B WDFY3 GCN1	1.24e-03	87	84	3	12465718
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FAT2 STARD8 PRORP ZNF160 BIRC6 GALNT16	1.26e-03	493	84	6	15368895
Pubmed	Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.	STARD8 GRID2IP ENC1	1.29e-03	88	84	3	21491433
Pubmed	Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.	TNRC6A TNRC6B	1.29e-03	22	84	2	22187428
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	GRID2IP CCT5 XIRP2 YTHDC2 BEND4 ZNF99	1.31e-03	497	84	6	36774506
Pubmed	Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.	TNRC6A TNRC6B	1.41e-03	23	84	2	28811219
Pubmed	Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract.	TDG MBD4	1.54e-03	24	84	2	23920106
Pubmed	HEY1 functions are regulated by its phosphorylation at Ser-68.	CCT5 FRG1 BIRC6	1.60e-03	95	84	3	27129302
Pubmed	Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations.	TDG MBD4	1.67e-03	25	84	2	20226869
Pubmed	The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.	CCT5 TNRC6A TNRC6B	1.70e-03	97	84	3	37151849
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NRXN3 CDC42BPA CCT5 TNRC6A NFASC CACNA1G	1.80e-03	529	84	6	14621295
Pubmed	Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.	CCT5 TNRC6A TNRC6B	1.91e-03	101	84	3	19167051
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	TENM3 TNRC6A USP12 TNRC6B WDFY3 FBXO34	1.92e-03	536	84	6	15840001
Pubmed	Polymorphisms in the base excision repair pathway and graft-versus-host disease.	TDG MBD4	1.95e-03	27	84	2	20574454
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	CDC42BPA PMPCB ADAM21 USP12 CES4A PLA2G4F GALNT16	1.95e-03	730	84	7	34857952
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	TENM3 TNRC6A USP12 TNRC6B WDFY3 FBXO34	1.96e-03	538	84	6	10512203
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	SERPINB8 CDC42BPA CCT5 TNRC6A YTHDC2 QDPR GCN1	1.98e-03	732	84	7	34732716
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DIP2B TENM3 TNRC6A	2.02e-03	103	84	3	10819331
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	PDE3B MXRA5 TLN1 NFASC PPFIA3 BIRC6 FBXO34	2.05e-03	736	84	7	29676528
Pubmed	Quality control by DNA repair.	TDG MBD4	2.09e-03	28	84	2	10583946
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF195 ZNF99	2.24e-03	29	84	2	14563677
GeneFamily	DNA glycosylases	TDG MBD4	4.06e-04	11	50	2	1024
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRIT2 MXRA5 NFASC ADGRA3	1.01e-03	161	50	4	593
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6A TNRC6B	2.16e-03	25	50	2	775
Disease	electrodermal activity measurement	NRXN3 TNRC6A	2.17e-05	3	80	2	EFO_0006866
Disease	plasma renin activity measurement	TENM3 XIRP2	2.58e-04	9	80	2	EFO_0006828
Disease	corpus callosum posterior volume measurement	ENO4 CFAP54 TNRC6B	3.85e-04	52	80	3	EFO_0010298
Disease	taurocholate measurement	CDC42BPA ADGRA3	1.34e-03	20	80	2	EFO_0010538
Disease	Uterine leiomyoma	TSPAN12 TNRC6B MYOCD	1.96e-03	91	80	3	HP_0000131
Disease	medial orbital frontal cortex volume measurement	FAT2 NRXN3	2.09e-03	25	80	2	EFO_0010315
Disease	sex interaction measurement, Crohn's disease	LRRK2 PRORP	4.55e-03	37	80	2	EFO_0000384, EFO_0008343
Disease	risk-taking behaviour	NRXN3 PSORS1C1 TNRC6A USP12 NFASC CACNA1G BIRC6	4.70e-03	764	80	7	EFO_0008579

Protein segments in the cluster

Peptide	Gene	Start	Entry
KCLFMSGLSEVQLNH	TDG	161	Q13569
AGLTFHALSGKNMCN	CFAP54	186	Q96N23
HNTTANMGTCLIAKS	ACY3	116	Q96HD9
MSQILSALGLCNSSA	BIRC6	2991	Q9NR09
NMACISKNQGSELSG	BUB1	181	O43683
ADFMKTTLNQGSCLH	ADAM21	381	Q9UKJ8
SMSNKLSNGHAVCLI	ATP13A3	101	Q9H7F0
KNMIHNCSLIASALT	ADGRA3	296	Q8IWK6
GNGLSASKSQIMNCL	GVINP1	1056	Q7Z2Y8
HQCSNRIGSMKIKSS	FBXO34	126	Q9NWN3
GKLLDSNHSQSMISC	BEND4	186	Q6ZU67
GMAKGAVHQLCQSLA	QDPR	151	P09417
QQQGKCLAATSTLMS	GALNT16	481	Q8N428
KMGQHSLVACSGNLN	PARP2	156	Q9UGN5
GNEINMLCKHTTSLL	LRRC9	776	Q6ZRR7
SQLCSMDSKANIVHG	ORC4	306	O43929
MNLSSKLAQLTCHGN	PMPCB	331	O75439
ALMDKSLHVGTQCAL	MLANA	56	Q16655
TCMASNSIGKSNLVI	LRIT2	326	A6NDA9
CRANVKSGAIMANLS	PPFIA3	861	O75145
AHMNAAVSLTNCALG	AQP7P3	91	A6NL99
KTTAQMLQTFGSCLA	MCF2L2	211	Q86YR7
SSSGIISMFNLCKKH	FAT2	2431	Q9NYQ8
KASQRKAMNTCGSHL	OR2W1	231	Q9Y3N9
SDSNLCNSCGHQMLK	PDE3B	571	Q13370
LCLMAQTALGALHTK	CES4A	11	Q5XG92
MSKSCGNNLAAISVG	GAPT	1	Q8N292
LAEMQNAAGVKSSCS	NRXN3	626	Q9Y4C0
AMNSICQTALSADGK	OBI1	266	Q5W0B1
LTGVKMSHSAVNALC	DIP2B	1166	Q9P265
EQNSTGKLCLSHMRA	HEXD	166	Q8WVB3
SGCKMLNHLFEGSNT	LRRK2	461	Q5S007
DCAKAVMSNLSAHGV	GCN1	1481	Q92616
LNRTGHQLADMLKSC	ASIC4	166	Q96FT7
RAQVHVCSSKMGALS	PLA2G4F	421	Q68DD2
KALTSLNEAMNVSCA	FAAP100	481	Q0VG06
LNEAMNVSCALLSSG	FAAP100	486	Q0VG06
QVCTAQMAGLHSSDK	MYOCD	681	Q8IZQ8
GAAACKVNLFMLSTN	OXER1	161	Q8TDS5
CLASNKMGSIRHTIS	NFASC	316	O94856
VFQNGKMALLASNSC	FRG1	141	Q14331
NCSHDKVVSMLQGSG	GRID2IP	331	A4D2P6
AKRMSCHALASGNKL	KLHL25	526	Q9H0H3
SMHKLLETQSTGACQ	CACNA1G	631	O43497
AMGCLASTVLGSLQK	CRYBG2	1421	Q8N1P7
KDCSMAALTSHLQNQ	MBD4	156	O95243
QITGKMSHLGCLTIN	ENO4	351	A6NNW6
QGCLDSSAARHKMTL	KIAA1210	396	Q9ULL0
AKRMSCHAVASGNKL	ENC1	526	O14682
SALDSMCSALSKLNA	GTF2IRD1	36	Q9UHL9
AGLLKHSAALSCLMA	LGSN	346	Q5TDP6
SIKVTVHCMNSSSGQ	NUP210L	1256	Q5VU65
AALSTACQNMIASLG	MN1	826	Q10571
NSKAMCVLAGSDHSA	SERGEF	211	Q9UGK8
NTDLHGQNIGKSMSC	PSD4	691	Q8NDX1
TTLGSKVVNSCHRQM	CCT5	171	P48643
CMNGTEAAQLSTKSR	STK11	391	Q15831
LGSILNASTVAAAMC	RO60	386	P10155
SQMAGCHSSIDVAKS	PRORP	146	O15091
SASNNKCSILMLADT	CDC42BPA	1171	Q5VT25
LSHDKSISFNGCMTQ	OR6Y1	91	Q8NGX8
AATQGLSHMISDCKK	STARD8	761	Q92502
AKGSTAAQMSQALCL	SERPINB8	46	P50452
KNCSAMGAHLVVINS	CLEC4E	106	Q9ULY5
TLSQTMGKSCHGNLV	XIRP2	1821	A4UGR9
IMCCANATGLHKLNL	TIGD2	211	Q4W5G0
ECGKAFNNSSTLMKH	ZNF99	541	A8MXY4
RAMTSHINICSKLGA	TMEM269	76	A0A1B0GVZ9
NECGKAFSMHSNLAT	ZNF160	456	Q9HCG1
NLLASSGQKTVDCMT	WDFY3	131	Q8IZQ1
SCGKVLSTASAMQRH	SLC2A4RG	206	Q9NR83
SAMQLSQCAKNLGTA	TLN1	1016	Q9Y490
MTCTDQKSHSQRALG	PSORS1C1	1	Q9UIG5
ASICTMGANASALEK	USP12	11	O75317
QCHTMRKSGTLSVLQ	TTC41P	791	Q6P2S7
TNGCLKSMTAQGLEL	TENM3	1591	Q9P273
MSLKNDNSQHLSCPS	TSPAN12	261	O95859
NCISALHKSMRGSDQ	WRNIP1	501	Q96S55
VCKMGFSLLTSLAQH	ZNF319	136	Q9P2F9
LISMGANVHSKASNG	YTHDC2	526	Q9H6S0
KAQKSLHMCVLGNTT	TNRC6A	1831	Q8NDV7
CSSLSNQQMILAGEK	ZNF195	366	O14628
AAKAQTALHMCVLGN	TNRC6B	1696	Q9UPQ9
NGLHLKSMENLQSCI	LRRIQ3	36	A6PVS8
KITAMAGHTISLNCS	MXRA5	2551	Q9NR99