Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Pubmed

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.

EDC3 CLASRP RNF111

1.70e-045148329892012
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF224 CLASRP SRRM5

8.87e-04119283chr19q13
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|343B / Donor, Lineage, Cell class and subclass (all cells)

ZNF224 RNF111

3.26e-0415582a4ff78e2efc6fe9a513bb2b64e5848f2ce65a09f
ToppCellNS-moderate-d_07-13-Myeloid-Mast_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DLC1 SRRM5

3.30e-041568217c38d3b03fc38cb125cf0d165b2fd694cd88edd
ToppCellBL-critical-LOC-Myeloid-Basophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ADGRB2 DLC1

3.56e-041628225ec9df914445b4daae4fd28fd0e60b64797c46d
ToppCellNS-moderate-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ADGRB2 DLC1

3.64e-041648235c673380f75cb4bfe080089bc723c4373bcc7a5
ToppCellmoderate-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ADGRB2 DLC1

3.73e-0416682c3835b424c63bf11a4e2c47635dc3787fc4a637a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRB2 DLC1

3.96e-0417182b0373ed8283ee1792b6a490bff93906546978593
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRB2 DLC1

3.96e-0417182b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ZNF224 EDC3

4.24e-041778236b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ZNF224 RNF111

4.68e-041868276cbc3610aedf8c19c17ad5faf6ef5e8980b6af5
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|368C / Donor, Lineage, Cell class and subclass (all cells)

ZNF224 RNF111

4.83e-0418982610d7cc1fc923dbd67d3b71f94d529a658982f87
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

ZNF224 RNF111

4.94e-04191829454f642c3621370fa23640b631301346b300950
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADGRB2 DLC1

5.30e-04198827dd874b09c81cc512ccc1e9b65f290a5f94d736e
Diseasebeta-amyloid 1-42 measurement

RNF111 DLC1

1.79e-048772EFO_0004670
Diseasesleep apnea measurement

DNM1P46 DLC1

3.18e-0411672EFO_0007817
Diseaseopioid dependence

RNF111 DLC1

1.31e-0323772EFO_0005611
Diseaseage-related hearing impairment

ADGRB2 DLC1

2.43e-0332472EFO_0005782
Diseaseintraocular pressure measurement

ADGRB2 DLC1

5.89e-0350972EFO_0004695
Diseaseapolipoprotein B measurement

ZNF224 CLASRP

9.82e-0366372EFO_0004615
Diseaseapolipoprotein A 1 measurement

RNF111 DLC1

1.57e-0284872EFO_0004614

Protein segments in the cluster

PeptideGeneStartEntry
ERPSLSQHRRHQSWS

ADGRB2

1531

O60241
RTRHNPSWRNHRSPS

C2orf16

1556

Q68DN1
RHSWRSRQSRHSGAT

DNM1P46

151

Q6ZS02
RRRHNSWSSSSRHPN

EDC3

156

Q96F86
RWHSFQSSHRPSLNS

DLC1

1001

Q96QB1
LRHHSSSRSRSSWSL

CLASRP

486

Q8N2M8
RSRSTLGHSRSHWSQ

RNF111

336

Q6ZNA4
RSHNWSRNPSKERSH

SRRM5

351

B3KS81
SWSSTRLTHQRRHSR

ZNF224

606

Q9NZL3