Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	RSF1 WRN MYO18A HLTF RFC1	3.09e-05	127	57	5	GO:0008094
GeneOntologyCellularComponent	myosin filament	MYH3 OBSCN MYO18A	4.24e-05	25	57	3	GO:0032982
MousePheno	abnormal prenatal body size	EPRS1 ZFAT STXBP3 TRAF3IP1 UBR5 RSF1 MYO18A CKAP5 PKNOX1 WDFY3 PAK1IP1 RFC1 THOC2	2.49e-05	1116	44	13	MP:0010866
MousePheno	decreased cortical ventricular zone thickness	WDFY3 THOC2	9.62e-05	5	44	2	MP:0014558
MousePheno	abnormal prenatal growth/weight/body size	EPRS1 ZFAT STXBP3 TRAF3IP1 UBR5 WNT2 RSF1 MYO18A CKAP5 PKNOX1 WDFY3 PAK1IP1 RFC1 THOC2	1.23e-04	1493	44	14	MP:0004196
MousePheno	abnormal cortical ventricular zone thickness	WDFY3 THOC2	1.44e-04	6	44	2	MP:0014556
MousePheno	embryonic lethality prior to tooth bud stage	KANSL3 EPRS1 STXBP3 TRAF3IP1 MYO18A CKAP5 PKNOX1 AK2 EXOC1 PAK1IP1 RFC1 THOC2 ARHGAP21	2.28e-04	1383	44	13	MP:0013293
Domain	PH	ARHGAP12 OBSCN ARHGEF18 PLCH1 ARHGAP20 ARHGAP21	1.79e-04	278	56	6	SM00233
Domain	PH_DOMAIN	ARHGAP12 OBSCN ARHGEF18 PLCH1 ARHGAP20 ARHGAP21	1.83e-04	279	56	6	PS50003
Domain	PH_domain	ARHGAP12 OBSCN ARHGEF18 PLCH1 ARHGAP20 ARHGAP21	1.86e-04	280	56	6	IPR001849
Domain	PH_dom-like	ARHGAP12 OBSCN ARHGEF18 WDFY3 PLCH1 ARHGAP20 ARHGAP21	2.70e-04	426	56	7	IPR011993
Domain	RhoGAP	ARHGAP12 ARHGAP20 ARHGAP21	8.52e-04	62	56	3	SM00324
Domain	RhoGAP	ARHGAP12 ARHGAP20 ARHGAP21	8.93e-04	63	56	3	PF00620
Domain	RHOGAP	ARHGAP12 ARHGAP20 ARHGAP21	9.34e-04	64	56	3	PS50238
Domain	RhoGAP_dom	ARHGAP12 ARHGAP20 ARHGAP21	9.34e-04	64	56	3	IPR000198
Domain	-	ARHGAP12 ARHGAP20 ARHGAP21	9.34e-04	64	56	3	1.10.555.10
Domain	-	ARHGAP12 OBSCN ARHGEF18 PLCH1 ARHGAP20 ARHGAP21	1.09e-03	391	56	6	2.30.29.30
Domain	IQ	MYH3 OBSCN MYO18A	1.26e-03	71	56	3	PF00612
Domain	Myosin_tail_1	MYH3 MYO18A	1.31e-03	18	56	2	PF01576
Domain	Myosin_tail	MYH3 MYO18A	1.31e-03	18	56	2	IPR002928
Domain	Myosin-like_IQ_dom	MYH3 MYO18A	1.46e-03	19	56	2	IPR027401
Domain	-	MYH3 MYO18A	1.46e-03	19	56	2	4.10.270.10
Domain	IQ	MYH3 OBSCN MYO18A	1.85e-03	81	56	3	SM00015
Domain	Rho_GTPase_activation_prot	ARHGAP12 ARHGAP20 ARHGAP21	2.34e-03	88	56	3	IPR008936
Domain	IQ_motif_EF-hand-BS	MYH3 OBSCN MYO18A	2.49e-03	90	56	3	IPR000048
Domain	IQ	MYH3 OBSCN MYO18A	2.74e-03	93	56	3	PS50096
Domain	PH	ARHGAP12 OBSCN ARHGEF18 ARHGAP21	4.91e-03	229	56	4	PF00169
Domain	Myosin_head_motor_dom	MYH3 MYO18A	5.79e-03	38	56	2	IPR001609
Domain	MYOSIN_MOTOR	MYH3 MYO18A	5.79e-03	38	56	2	PS51456
Domain	Myosin_head	MYH3 MYO18A	5.79e-03	38	56	2	PF00063
Domain	MYSc	MYH3 MYO18A	5.79e-03	38	56	2	SM00242
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	IVD EPRS1 MYH3 CENPF TCHHL1 U2SURP ARHGAP12 RSF1 MYO18A ANKRD26 MAGI3 PLCH1 NCAPH ARHGAP21 ESF1	9.49e-09	1442	58	15	35575683
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EPRS1 PRCC U2SURP RSF1 CKAP5 ANKRD26 AK2 RFC1 THOC2 NCAPH ARHGAP21 ESF1	3.76e-08	934	58	12	33916271
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	EPRS1 CENPF KLHL7 MYO18A CKAP5 PUM3 PAK1IP1 RFC1 THOC2 NCAPH IKBIP ESF1 NSD3	1.17e-07	1257	58	13	36526897
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	KANSL3 EPRS1 CENPF U2SURP HMGXB4 WRN CKAP5 HLTF RFC1 THOC2 IKBIP NSD3	1.22e-06	1294	58	12	30804502
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	UBR5 CENPF U2SURP RSF1 CKAP5 PUM3 RFC1 THOC2 ESF1	1.29e-06	653	58	9	22586326
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	EPRS1 U2SURP WRN CKAP5 HLTF RFC1 THOC2	1.57e-06	340	58	7	24332808
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EPRS1 UBR5 U2SURP RSF1 CKAP5 HLTF PUM3 EXOC1 WDFY3 RFC1 NCAPH ESF1	1.94e-06	1353	58	12	29467282
Pubmed	RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.	WRN HLTF RFC1	2.43e-06	16	58	3	26474068
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	EPRS1 STXBP3 CENPF VPS13C U2SURP CKAP5 PUM3 PAK1IP1 RFC1 THOC2 NCAPH ESF1	3.32e-06	1425	58	12	30948266
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EPRS1 PRCC U2SURP HMGXB4 RSF1 PUM3 RFC1 THOC2 ESF1 NSD3	3.64e-06	954	58	10	36373674
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CENPF WRN MYO18A CKAP5 PUM3 PAK1IP1 RFC1 THOC2 ESF1	4.39e-06	759	58	9	35915203
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	KANSL3 UBR5 RSF1 HLTF PAK1IP1 RFC1 THOC2 NCAPH ESF1 NSD3	6.23e-06	1014	58	10	32416067
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EPRS1 FBXL16 TRAF3IP1 KLHL7 CKAP5 PKNOX1 MAGI3 EXOC1 WDFY3 ARHGAP21 BFSP1	7.75e-06	1285	58	11	35914814
Pubmed	Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway.	HLTF RFC1	8.19e-06	3	58	2	30335157
Pubmed	Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model.	KMT5B WDFY3	8.19e-06	3	58	2	30564305
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	STXBP3 UBR5 KLHL7 VPS13C ARHGAP12 CKAP5 ANKRD26 MAGI3 ARHGAP21	1.12e-05	853	58	9	28718761
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	RSF1 CKAP5 ANKRD26 PUM3 EXOC1 RFC1 THOC2 NSD3	1.14e-05	645	58	8	25281560
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MYH3 ZFAT OBSCN ANKRD26 PUM3 EXOC1 ARHGAP21	1.87e-05	497	58	7	23414517
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	UBR5 CENPF RFC1 NCAPH ESF1	2.70e-05	210	58	5	16565220
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	EPRS1 MYH3 CENPF VPS13C OBSCN CKAP5 MAGI3 ARHGAP20	2.92e-05	736	58	8	29676528
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	KMT5B HMGXB4 RSF1 RFC1 PLCH1 THOC2 NSD3	2.92e-05	533	58	7	30554943
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	EPRS1 UBR5 U2SURP CKAP5 RFC1	3.45e-05	221	58	5	29991511
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KANSL3 EPRS1 MYO18A CKAP5 PAK1IP1 RFC1 THOC2 ESF1	4.17e-05	774	58	8	15302935
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	TRAF3IP1 UBR5 CKAP5 HLTF ARHGEF18 AK2	4.73e-05	390	58	6	17643375
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	EPRS1 U2SURP HLTF RFC1 NCAPH NSD3	5.01e-05	394	58	6	27248496
Pubmed	Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.	KMT5B WDFY3	5.71e-05	7	58	2	36897941
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	KANSL3 EPRS1 KLHL7 U2SURP WRN HLTF PAK1IP1 RFC1 THOC2 NCAPH	5.87e-05	1318	58	10	30463901
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	EPRS1 VPS13C CKAP5 ARHGAP21	6.37e-05	128	58	4	30995482
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	HMGXB4 RSF1 WRN HLTF PUM3 RFC1 NSD3	6.70e-05	608	58	7	36089195
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	KANSL3 U2SURP HMGXB4 NCAPH	7.61e-05	134	58	4	25452129
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	KANSL3 EPRS1 UBR5 U2SURP CKAP5 HLTF PUM3 RFC1 THOC2	8.28e-05	1103	58	9	34189442
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	U2SURP WRN RFC1 THOC2 ADARB2	9.05e-05	271	58	5	32433965
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	EPRS1 UBR5 U2SURP MYO18A CKAP5 AK2 RFC1 NCAPH ESF1	1.13e-04	1149	58	9	35446349
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	KANSL3 VPS13C ARHGAP20 ARHGAP21	1.27e-04	153	58	4	10718198
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	U2SURP PUM3 PAK1IP1 RFC1 ARHGAP21 ESF1	1.53e-04	483	58	6	36912080
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	U2SURP CKAP5 HLTF RFC1 THOC2 IKBIP	1.58e-04	486	58	6	30940648
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	EPRS1 ARHGAP12 CKAP5 ANKRD26 MAGI3 PLCH1 ARHGAP21	1.72e-04	708	58	7	39231216
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	STXBP3 UBR5 VPS13C MYO18A MAGI3 AK2 ARHGAP21	1.89e-04	719	58	7	35337019
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TRAF3IP1 UBR5 CENPF KLHL7 CKAP5 ARHGEF18 WDFY3 ARHGAP21	1.89e-04	963	58	8	28671696
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	EPRS1 CENPF RSF1 RFC1 THOC2 NCAPH	1.90e-04	503	58	6	16964243
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	CENPF U2SURP HLTF PUM3 PAK1IP1 RFC1 THOC2 ESF1	2.26e-04	989	58	8	36424410
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	UBR5 VPS13C MYO18A HLTF AK2 NCAPH ARHGAP21	2.52e-04	754	58	7	35906200
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	UBR5 VPS13C WRN ANKRD26 NCAPH ARHGAP21 ESF1	3.02e-04	777	58	7	35844135
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	HLTF PUM3 RFC1 NCAPH	3.21e-04	195	58	4	19454010
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	IVD CENPF ARHGEF18 ARHGAP20	3.34e-04	197	58	4	20811636
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	EPRS1 WRN MYO18A CKAP5	3.67e-04	202	58	4	33005030
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	EPRS1 U2SURP CKAP5 EXOC1 RFC1 THOC2 ARHGAP21	3.85e-04	809	58	7	32129710
Pubmed	Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.	UBR5 CKAP5	4.11e-04	18	58	2	26598607
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	PRCC U2SURP CKAP5 HLTF EXOC1 NCAPH	4.14e-04	582	58	6	20467437
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	EPRS1 OBSCN ARHGEF18 THOC2 ARHGAP21 IKBIP ESF1 LRRC71	4.18e-04	1084	58	8	11544199
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	KANSL3 EPRS1 TCHHL1 WRN PUM3 PAK1IP1 RFC1 THOC2 IKBIP	4.18e-04	1371	58	9	36244648
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	PUM3 RFC1 THOC2 NCAPH	4.64e-04	215	58	4	30462309
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	EPRS1 U2SURP RFC1	4.66e-04	90	58	3	35654790
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	EPRS1 U2SURP PUM3 PAK1IP1 RFC1 THOC2 NSD3	5.06e-04	847	58	7	35850772
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	IVD EPRS1 U2SURP CKAP5 THOC2 NCAPH IKBIP	5.06e-04	847	58	7	35235311
Pubmed	Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.	U2SURP CKAP5 EXOC1 IKBIP	5.23e-04	222	58	4	35941108
Pubmed	Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.	UBR5 HLTF NSD3	5.46e-04	95	58	3	29490077
Pubmed	ETAA1 acts at stalled replication forks to maintain genome integrity.	WRN HLTF	5.62e-04	21	58	2	27723720
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	MYH3 CENPF ARHGEF18 PUM3 PAK1IP1	6.09e-04	410	58	5	26949251
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	EPRS1 UBR5 HLTF PLCH1	6.17e-04	232	58	4	25515538
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	TEX15 RFC1 PLCH1 THOC2	6.37e-04	234	58	4	36243803
Pubmed	A protein interaction landscape of breast cancer.	IVD UBR5 MYO18A PUM3 PAK1IP1 ARHGAP21	6.49e-04	634	58	6	34591612
Pubmed	Nucleolar proteome dynamics.	HLTF PUM3 RFC1 ADARB2 ESF1	6.72e-04	419	58	5	15635413
Pubmed	Genomic variants in an inbred mouse model predict mania-like behaviors.	OBSCN HLTF	6.76e-04	23	58	2	29768498
Pubmed	Defining the membrane proteome of NK cells.	EPRS1 UBR5 MYO18A CKAP5 HLTF EXOC1 NCAPH IKBIP	6.83e-04	1168	58	8	19946888
Pubmed	The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.	UBR5 U2SURP HMGXB4	7.11e-04	104	58	3	31365120
Pubmed	Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.	VPS13C U2SURP	7.37e-04	24	58	2	35543156
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EPRS1 PRCC HLTF PLCH1 ARHGAP21 ESF1	7.39e-04	650	58	6	38777146
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	UBR5 VPS13C MYO18A MAGI3 ARHGAP21	7.55e-04	430	58	5	32581705
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	EPRS1 UBR5 U2SURP HLTF PUM3 RFC1	7.69e-04	655	58	6	35819319
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	EPRS1 U2SURP RSF1 CKAP5 RFC1	8.45e-04	441	58	5	31239290
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	EPRS1 CENPF CKAP5 NCAPH	8.91e-04	256	58	4	33397691
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	HLTF PKNOX1 PUM3 ESF1	9.30e-04	259	58	4	30404004
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	UBR5 CENPF PRCC WRN THOC2	9.53e-04	453	58	5	29656893
Pubmed	DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.	WRN HLTF	1.00e-03	28	58	2	32937373
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	UBR5 CENPF HMGXB4	1.05e-03	119	58	3	23508102
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	TRAF3IP1 CENPF EXOC1	1.08e-03	120	58	3	31413325
Pubmed	Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.	ZFAT ADAMTSL3	1.08e-03	29	58	2	21998595
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	RSF1 RFC1 TTC5 NCAPH IKBIP	1.11e-03	469	58	5	27634302
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	KANSL3 CENPF PRCC HMGXB4 ARHGAP21	1.14e-03	472	58	5	38943005
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	EPRS1 MYO18A ARHGAP21 ESF1	1.14e-03	274	58	4	34244482
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	WRN RFC1 THOC2 ESF1	1.29e-03	283	58	4	30585729
Pubmed	HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.	CENPF HLTF	1.31e-03	32	58	2	27114546
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	EPRS1 U2SURP PUM3 PAK1IP1 THOC2 ADARB2	1.35e-03	731	58	6	29298432
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	U2SURP CKAP5 MAGI3	1.36e-03	130	58	3	12421765
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	EPRS1 WRN CKAP5 ANKRD26 PLCH1 ARHGAP21	1.36e-03	732	58	6	34732716
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ANKRD26 ARHGEF18 MAGI3 PUM3 PLCH1	1.39e-03	493	58	5	15368895
Pubmed	Hypertrophic Cardiomyopathy Overview	OBSCN PRKAG2	1.48e-03	34	58	2	20301725
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TRAF3IP1 KLHL7 PRCC WRN EXOC1 IKBIP TULP1 ESF1	1.50e-03	1321	58	8	27173435
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EPRS1 UBR5 CENPF U2SURP CKAP5 PUM3 THOC2	1.53e-03	1024	58	7	24711643
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	EPRS1 CENPF PRCC U2SURP ESF1	1.55e-03	506	58	5	30890647
Pubmed	A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.	RSF1 ESF1	1.57e-03	35	58	2	29104064
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	MAGI3 ARHGAP21	1.66e-03	36	58	2	26053890
Interaction	HECTD1 interactions	EPRS1 CENPF U2SURP WRN MYO18A CKAP5 PUM3 ZNF215 EXOC1 PAK1IP1 RFC1 THOC2 NCAPH ESF1	5.41e-07	984	58	14	int:HECTD1
Interaction	NAA40 interactions	EPRS1 PRCC U2SURP RSF1 CKAP5 ANKRD26 AK2 RFC1 THOC2 NCAPH ARHGAP21 ESF1	1.80e-05	978	58	12	int:NAA40
Interaction	CAVIN1 interactions	UBR5 CKAP5 MAGI3 EXOC1 TTC5 ARHGAP21 ESF1	1.99e-05	292	58	7	int:CAVIN1
Interaction	TERF2IP interactions	KANSL3 PRCC U2SURP HMGXB4 RSF1 WDFY3 RFC1 THOC2 NSD3	2.62e-05	552	58	9	int:TERF2IP
Interaction	H1-5 interactions	TCHHL1 U2SURP RSF1 ANKRD26 PUM3 CCDC168 NCAPH CLDN10	5.11e-05	463	58	8	int:H1-5
Interaction	NUP43 interactions	KANSL3 UBR5 RSF1 WRN HLTF AK2 CCDC168 RFC1 NSD3	6.87e-05	625	58	9	int:NUP43
Interaction	YWHAZ interactions	IVD KLHL7 KMT5B PRCC RSF1 MYO18A CKAP5 ANKRD26 ARHGEF18 PUM3 WDFY3 PLCH1 ARHGAP21	7.53e-05	1319	58	13	int:YWHAZ
Interaction	CENPA interactions	HMGXB4 RSF1 HLTF RFC1 THOC2 ESF1 NSD3	1.00e-04	377	58	7	int:CENPA
Cytoband	20p12.1	BFSP1 ESF1	4.62e-04	25	58	2	20p12.1
Cytoband	10p12.1	ANKRD26 ARHGAP21	7.59e-04	32	58	2	10p12.1
Cytoband	15q25.2	C15orf40 ADAMTSL3	1.37e-03	43	58	2	15q25.2
Cytoband	8p12	WRN TEX15	1.63e-03	47	58	2	8p12
Cytoband	1q41	EPRS1 CENPF	3.19e-03	66	58	2	1q41
Cytoband	2q11.2	KANSL3 NCAPH	3.79e-03	72	58	2	2q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr8p12	WRN TEX15	3.79e-03	72	58	2	chr8p12
Cytoband	Ensembl 112 genes in cytogenetic band chr1q41	EPRS1 CENPF	6.23e-03	93	58	2	chr1q41
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP12 ARHGAP20 ARHGAP21	1.83e-04	50	40	3	721
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT5B NSD3	2.56e-03	34	40	2	487
GeneFamily	PDZ domain containing	MYO18A MAGI3 ARHGAP21	4.58e-03	152	40	3	1220
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	STXBP3 UBR5 CENPF U2SURP ARHGAP12 HMGXB4 WRN CKAP5 HLTF PUM3 WDFY3 THOC2	2.49e-07	856	57	12	M4500
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	EPRS1 STXBP3 VPS13C RSF1 WRN HLTF PUM3 EXOC1 RFC1 ESF1	1.35e-06	656	57	10	M18979
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	UBR5 CENPF U2SURP ARHGAP12 HMGXB4 WRN CKAP5 PUM3	7.24e-06	466	57	8	M13522
Coexpression	RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP	EPRS1 CENPF U2SURP RSF1 CKAP5 PUM3 RFC1 THOC2 ESF1	2.37e-05	721	57	9	M10237
Coexpression	PUJANA_BRCA2_PCC_NETWORK	UBR5 CENPF HMGXB4 WRN CKAP5 HLTF NCAPH	3.74e-05	426	57	7	M9516
Coexpression	SHEN_SMARCA2_TARGETS_UP	STXBP3 VPS13C U2SURP HLTF EXOC1 WDFY3 RWDD3	3.91e-05	429	57	7	M29
Coexpression	GSE38696_LIGHT_ZONE_VS_DARK_ZONE_BCELL_UP	UBR5 KLHL7 HLTF ARHGEF18 THOC2	5.03e-05	184	57	5	M9005
Coexpression	GSE24634_TEFF_VS_TCONV_DAY5_IN_CULTURE_UP	TRAF3IP1 CENPF KLHL7 CKAP5 PUM3	7.46e-05	200	57	5	M4617
Coexpression	GSE21379_TFH_VS_NON_TFH_CD4_TCELL_UP	KMT5B HMGXB4 RSF1 CLDN10 NSD3	7.46e-05	200	57	5	M7500
Coexpression	GSE37301_LYMPHOID_PRIMED_MPP_VS_COMMON_LYMPHOID_PROGENITOR_UP	MYH3 KLHL7 CKAP5 RFC1 NCAPH	7.46e-05	200	57	5	M8853
Coexpression	SMID_BREAST_CANCER_BASAL_UP	EPRS1 CENPF KLHL7 AK2 PAK1IP1 PLCH1 NCAPH CLDN10	8.81e-05	662	57	8	M8124
Coexpression	LAKE_ADULT_KIDNEY_C3_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S1_S2	ANKRD26 PUM3 WDFY3 THOC2 CLDN10	1.19e-04	221	57	5	M39222
Coexpression	MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_9	WRN NSD3	1.29e-04	8	57	2	M9239
Coexpression	FISCHER_G2_M_CELL_CYCLE	CENPF KMT5B CKAP5 PKNOX1 NCAPH	1.62e-04	236	57	5	M130
Coexpression	DODD_NASOPHARYNGEAL_CARCINOMA_UP	EPRS1 CENPF U2SURP HMGXB4 WRN CKAP5 AK2 RFC1 NCAPH IKBIP NSD3	1.93e-04	1407	57	11	M14427
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	EPRS1 UBR5 CENPF VPS13C RSF1 CKAP5 ANKRD26 MAGI3 RWDD3 ESF1	1.34e-06	532	57	10	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3	TRAF3IP1 UBR5 CENPF CKAP5 ANKRD26 ESF1	1.25e-05	192	57	6	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000	EPRS1 TRAF3IP1 UBR5 CENPF U2SURP CKAP5 ANKRD26 PUM3 PLCH1 ARHGAP21 ESF1	5.45e-05	989	57	11	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	VPS13C U2SURP RSF1 ANKRD26 THOC2 CLDN10	2.32e-07	199	58	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	EPRS1 RSF1 CKAP5 WDFY3 THOC2	5.25e-06	193	58	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	RSF1 ANKRD26 PUM3 THOC2 ESF1	5.81e-06	197	58	5	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	CENPF VPS13C RSF1 ANKRD26 CLDN10	5.95e-06	198	58	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	VPS13C U2SURP RSF1 RFC1 NSD3	6.10e-06	199	58	5	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	RSF1 ANKRD26 RFC1 THOC2 NSD3	6.10e-06	199	58	5	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCell	Control-Control-Myeloid-immature_Neutrophil\|Control / Disease, condition lineage and cell class	KANSL3 CENPF CKAP5 PAK1IP1 NCAPH	6.25e-06	200	58	5	118321ac443feb42aee171baccfc4610f00a8822
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CCDC60 CENPF TEX15 NCAPH	2.82e-05	134	58	4	4d8f7ddad02fe76a614771e115ebb8e04623ba85
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Krt80_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYH3 WNT2 OBSCN CLDN10	4.49e-05	151	58	4	f50c5ae9dae507df750df25e151b58685fec70ce
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Cpa6\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYH3 WNT2 OBSCN CLDN10	4.85e-05	154	58	4	12cbc38bc1f7231c67e1d2d5e86e95bc12e24682
ToppCell	Control-B_naive-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	KMT5B ARHGEF18 PUM3 NSD3	7.28e-05	171	58	4	d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell	COVID-19_Mild-Neu_2\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	KLHL7 ARHGAP12 WRN RWDD3	7.45e-05	172	58	4	f5fd08b42c002d4693646b27e7b708eceb49524f
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l44\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRAF3IP1 C15orf40 RWDD3 NCAPH	7.62e-05	173	58	4	b6bb2a136a40f0946bbcde8d5972d3f059d080c7
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPF CKAP5 CCDC168 NCAPH	7.96e-05	175	58	4	d43ae33a6256606ce848247cad32d74f21b38988
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT5B VPS13C CKAP5 ARHGAP21	8.14e-05	176	58	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	WNT2 MAGI3 ARHGAP20 ARHGAP21	8.32e-05	177	58	4	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	ARHGAP12 MYO18A ANKRD26 WDFY3	8.32e-05	177	58	4	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	Ciliated_cells-A-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	CCDC60 MYO18A CLDN10 LRRC71	8.69e-05	179	58	4	1c41314b6fcfcac8d62034e7037570120d58f20f
ToppCell	Control-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	KANSL3 PRCC CKAP5 NCAPH	9.67e-05	184	58	4	ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell	Anterior_Cingulate_gyrus_(CgG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP3 ARHGAP12 PUM3 PLCH1	1.01e-04	186	58	4	32af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CENPF CKAP5 CCDC168 NCAPH	1.05e-04	188	58	4	319fbeca200ab998daf49fcaee0bfdb57bf7ee4b
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CENPF WNT2 CKAP5 NCAPH	1.07e-04	189	58	4	d049f33115610bda4489968759f754730698b9cd
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CENPF CKAP5 NCAPH IKBIP	1.12e-04	191	58	4	0ba5b112a82e489f5a21966f78a403a7436ce73b
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Polychromatic_Erythroblast\|Megakaryocytic-erythropoietic / Lineage, cell class and subclass	CENPF HLTF PAK1IP1 NCAPH	1.31e-04	199	58	4	fa698f00d2dad74d28b4696c8c23dce70f123e52
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	CENPF CKAP5 NCAPH IKBIP	1.31e-04	199	58	4	d8f904f531bfe091b7d8caaa147ea4a03d627995
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating-cycling_dorsal_progenitors\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	CENPF CKAP5 NCAPH IKBIP	1.31e-04	199	58	4	ca17e8c0f5bc2c41ce28351a7418d934404e563b
ToppCell	Sigmoid-(1)_T_cell-(18)_cycling_gd_T\|Sigmoid / shred on region, Cell_type, and subtype	IVD CENPF MYO18A NCAPH	1.33e-04	200	58	4	6e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCell	Sigmoid-T_cell-cycling_gd_T\|Sigmoid / Region, Cell class and subclass	IVD CENPF MYO18A NCAPH	1.33e-04	200	58	4	9769185abae084ffac36420c749625e679b70ca8
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	UBR5 CENPF ARHGAP12 WDFY3 PLCH1 NCAPH	5.32e-06	174	58	6	7530_DN
Drug	Alexidine dihydrochloride [22573-93-9]; Down 200; 6.8uM; PC3; HT_HG-U133A	IVD CENPF PKNOX1 WDFY3 RWDD3 PLCH1	1.05e-05	196	58	6	3699_DN
Drug	Sulfapyridine [144-83-2]; Down 200; 16uM; PC3; HT_HG-U133A	TRAF3IP1 CENPF VPS13C U2SURP PKNOX1 WDFY3	1.18e-05	200	58	6	7151_DN
Disease	exercise test	CCDC60 WRN	6.81e-04	20	57	2	EFO_0004328
Disease	cerebral amyloid deposition measurement	CCDC60 AK2 WDFY3	8.34e-04	95	57	3	EFO_0007707
Disease	Retinitis Pigmentosa	KLHL7 ARHGEF18 TULP1	1.08e-03	104	57	3	C0035334
Disease	Dupuytren Contracture	KLHL7 WNT2 TULP1	1.21e-03	108	57	3	EFO_0004229
Disease	insomnia measurement	TRAF3IP1 UBR5 TEX15 PLCH1 ARHGAP21	1.64e-03	443	57	5	EFO_0007876

Protein segments in the cluster

Peptide	Gene	Start	Entry
MDTKKKKDVSSPGGS	PRKAG2	6	Q9UGJ0
EIAGKMDLKSSSKLK	ARHGEF18	656	Q6ZSZ5
MVKKKGIAAKSSKTS	CXorf66	81	Q5JRM2
MKKIFSKKGESPLGS	ANKRD26	1	Q9UPS8
MKCTKVGGSDKAKAK	CLDN10	101	P78369
SKSTIKKINKDKSMG	CCDC60	191	Q8IWA6
TFEGTGPTKKKAKMR	ADARB2	166	Q9NS39
MEVKGKKQFTGKSTK	PUM3	1	Q15397
KPEKKSASSGEMSKK	TRAF3IP1	301	Q8TDR0
TKTAKMKTDKKENAG	MAGI3	661	Q5TCQ9
DTGMSKKKSRQGKLV	KMT5B	606	Q4FZB7
GKKLKATMDAGKLVS	AK2	61	P54819
GIKKMKTSCKFKIDS	ESF1	136	Q9H501
RKTFTTGMAAVKKKS	MYO18A	1006	Q92614
KTDKTQTMKTPKGLG	LRRC71	361	Q8N4P6
MAASGVEKSSKKKTE	KLHL7	1	Q8IXQ5
KKKKKSSPQSTDTAM	HMGXB4	96	Q9UGU5
KRKASSSEGSMKVKA	HMGXB4	476	Q9UGU5
EKGMPGFSTSKKLDK	IVD	231	P26440
MSEVKSRKKSGPKGA	IKBIP	1	Q70UQ0
GATIEMASKDKSSKK	ARHGAP12	526	Q8IWW6
GKKLSSSSKVGMEVK	OBSCN	1111	Q5VST9
KDGKKLSSSSKVRME	OBSCN	1201	Q5VST9
AKSAQGKKMPSKTSL	CKAP5	1136	Q14008
ESFSKKSKKAVMSGI	CENPF	2951	P49454
VETMIGKTKSDKKKS	BFSP1	646	Q12934
ISKAKKKSEGLTQSM	KANSL3	441	Q9P2N6
IKMTGTTKESKKFAT	EXOC1	431	Q9NV70
SSVPTTKKKMLKKGA	HLTF	446	Q14527
KCMEGLKTSFPKTGK	CCDC168	2071	Q8NDH2
SCTMKGEEKSPKTKK	RSF1	561	Q96T23
SKKGVKAMSLKRSTI	FBXL16	191	Q8N461
RLAGGSCTKKKMKTL	ARHGAP20	26	Q9P2F6
HTKEMPTSGSKEKTK	EPRS1	706	P07814
TEEKTMKSFSKKKGE	PRCC	431	Q92733
MLDSSCSETPKTKKK	PKNOX1	321	P55347
TDAMIKKKTKSSKPS	RFC1	1116	P35251
ATGDLAKKKDSKMKG	MYH3	201	P11055
DTSKKLMDKTKRGGL	WRN	1416	Q14191
KLMKEISSTKKATEG	STXBP3	306	O00186
IGKMSTAKRTLSKKE	U2SURP	86	O15042
SATEMGTTKKAVKPK	NCAPH	201	Q15003
AEMPKKAGATTKGKS	C15orf40	26	Q8WUR7
GTKMRKTKKKGSGEA	TULP1	191	O00294
KVDVDSSGKKCKEKM	RWDD3	201	Q9Y3V2
SSGKKCKEKMISVLF	RWDD3	206	Q9Y3V2
SCDPKKMGSAKDSKG	WNT2	136	P09544
MCGKKFKSKGTLKSH	ZFAT	941	Q9P243
KSEKMDKISSGGKKE	THOC2	1546	Q8NI27
EMGTSKEKAKTVTLK	WDFY3	3106	Q8IZQ1
KGKVKTKKLQSMLGS	TTC5	281	Q8N0Z6
PQTCKSMKGSELKKA	VPS13C	886	Q709C8
ATKESGLISTKKRKM	PAK1IP1	361	Q9NWT1
MIPSSSASKKKCEKG	NSD3	906	Q9BZ95
TASAPAKGRKKSKMG	PLCH1	921	Q4KWH8
SIKEKMKAGSRTGKP	ZNF215	146	Q9UL58
LKTNKPMAGSKKTSS	TCHHL1	206	Q5QJ38
KTSGEKKCLSRKSMA	TEX15	1096	Q9BXT5
TKVFDVMKKGKSTGS	ARHGAP21	1731	Q5T5U3
AKNKKPKSSAGISSM	UBR5	511	O95071
SKIKSEMKTKLGEQG	ADAMTSL3	881	P82987