Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	triplex DNA binding	DDX12P DDX11L8 DDX11	1.87e-07	4	73	3	GO:0045142
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	DDX12P CHD9 CHD1 CHD2 DDX11L8 DDX11	7.06e-06	127	73	6	GO:0008094
GeneOntologyMolecularFunction	5'-3' DNA helicase activity	DDX12P DDX11L8 DDX11	7.57e-06	11	73	3	GO:0043139
GeneOntologyMolecularFunction	G-quadruplex DNA binding	DDX12P DDX11L8 DDX11	1.66e-05	14	73	3	GO:0051880
GeneOntologyMolecularFunction	helicase activity	DDX12P CHD9 CHD1 CHD2 DDX11L8 DDX11	2.45e-05	158	73	6	GO:0004386
GeneOntologyMolecularFunction	DNA replication origin binding	DDX12P DDX11L8 DDX11	3.68e-05	18	73	3	GO:0003688
GeneOntologyMolecularFunction	glycogen phosphorylase activity	PYGL PYGM	3.95e-05	3	73	2	GO:0008184
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR2 RYR3	7.87e-05	4	73	2	GO:0005219
GeneOntologyMolecularFunction	1,4-alpha-oligoglucan phosphorylase activity	PYGL PYGM	1.31e-04	5	73	2	GO:0004645
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR2 RYR3	1.96e-04	6	73	2	GO:0048763
GeneOntologyMolecularFunction	ATP hydrolysis activity	DDX12P ATAD3C CHD9 CHD1 CHD2 ATP10A DDX11L8 DDX11	2.03e-04	441	73	8	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD9 CHD1 CHD2	3.33e-04	37	73	3	GO:0140658
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	DDX12P CHD9 CHD1 CHD2 DDX11L8 DDX11	3.93e-04	262	73	6	GO:0140097
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	XRN2 DDX12P DIS3L CARS1 CHD9 CHD1 CHD2 DDX11L8 DDX11	5.56e-04	645	73	9	GO:0140640
GeneOntologyMolecularFunction	4 iron, 4 sulfur cluster binding	DDX12P DDX11L8 DDX11	6.77e-04	47	73	3	GO:0051539
GeneOntologyMolecularFunction	pyridoxal phosphate binding	PYGL PYGM DDC	1.13e-03	56	73	3	GO:0030170
GeneOntologyMolecularFunction	vitamin B6 binding	PYGL PYGM DDC	1.19e-03	57	73	3	GO:0070279
GeneOntologyMolecularFunction	chromatin binding	DDX12P HDAC8 CHD1 CHD2 DDX11L8 STAT3 DNAJC2 DDX11 OVOL2	1.45e-03	739	73	9	GO:0003682
GeneOntologyMolecularFunction	DNA helicase activity	DDX12P DDX11L8 DDX11	1.52e-03	62	73	3	GO:0003678
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	KCNN3 RYR2 RYR3 CHRNG	1.73e-03	140	73	4	GO:0099094
GeneOntologyMolecularFunction	ATP-dependent activity	DDX12P ATAD3C CHD9 CHD1 CHD2 ATP10A DDX11L8 DDX11	1.77e-03	614	73	8	GO:0140657
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR2 RYR3	1.94e-03	18	73	2	GO:0015278
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	RHOG DDX12P ATAD3C CHD9 CHD1 CHD2 ATP10A DDX11L8 DDX11	2.01e-03	775	73	9	GO:0017111
GeneOntologyMolecularFunction	AMP binding	PYGL PYGM	2.65e-03	21	73	2	GO:0016208
GeneOntologyMolecularFunction	iron-sulfur cluster binding	DDX12P DDX11L8 DDX11	2.93e-03	78	73	3	GO:0051536
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DDX12P DDX11L8 DDX11	3.15e-03	80	73	3	GO:0008186
GeneOntologyMolecularFunction	pyrophosphatase activity	RHOG DDX12P ATAD3C CHD9 CHD1 CHD2 ATP10A DDX11L8 DDX11	3.42e-03	839	73	9	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	RHOG DDX12P ATAD3C CHD9 CHD1 CHD2 ATP10A DDX11L8 DDX11	3.44e-03	840	73	9	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	RHOG DDX12P ATAD3C CHD9 CHD1 CHD2 ATP10A DDX11L8 DDX11	3.44e-03	840	73	9	GO:0016818
GeneOntologyMolecularFunction	metal cluster binding	DDX12P DDX11L8 DDX11	3.49e-03	83	73	3	GO:0051540
GeneOntologyBiologicalProcess	sister chromatid cohesion	DDX12P SLF1 BUB1 HDAC8 DDX11L8 DDX11	1.23e-07	67	72	6	GO:0007062
GeneOntologyBiologicalProcess	positive regulation of sister chromatid cohesion	SLF1 BUB1 DDX11	6.60e-06	11	72	3	GO:0045876
GeneOntologyBiologicalProcess	establishment of sister chromatid cohesion	DDX12P DDX11L8 DDX11	6.60e-06	11	72	3	GO:0034085
GeneOntologyBiologicalProcess	regulation of sister chromatid cohesion	SLF1 BUB1 DDX11	4.46e-05	20	72	3	GO:0007063
GeneOntologyCellularComponent	Ctf18 RFC-like complex	DDX12P DDX11L8 DDX11	4.82e-06	10	73	3	GO:0031390
GeneOntologyCellularComponent	sarcoplasmic reticulum	SYNE2 PYGM RYR2 RYR3	2.56e-04	88	73	4	GO:0016529
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	SYNE2 RYR2 RYR3	5.22e-04	45	73	3	GO:0033017
GeneOntologyCellularComponent	smooth endoplasmic reticulum	STX17 RYR2 RYR3	5.57e-04	46	73	3	GO:0005790
GeneOntologyCellularComponent	sarcoplasm	SYNE2 PYGM RYR2 RYR3	6.83e-04	114	73	4	GO:0016528
MousePheno	increased allantois apoptosis	DDX12P DDX11L8 DDX11	3.36e-06	8	56	3	MP:0003891
MousePheno	absent paraxial mesoderm	DDX12P DDX11L8 DDX11	5.03e-06	9	56	3	MP:0012184
MousePheno	decreased paraxial mesoderm size	DDX12P DDX11L8 DDX11	1.31e-05	12	56	3	MP:0012183
MousePheno	abnormal chromosome number	DDX12P BUB1 HDAC8 DDX11L8 DDX11	2.34e-05	86	56	5	MP:0004023
MousePheno	small allantois	DDX12P DDX11L8 DDX11	3.29e-05	16	56	3	MP:0004559
MousePheno	decreased embryo size	DDX12P HDAC8 ANKRD11 CHD1 GCN1 DDC DDX11L8 STAT3 CHRNG DDX11 OVOL2	5.03e-05	659	56	11	MP:0001698
MousePheno	placental labyrinth hypoplasia	DDX12P DDX11L8 DDX11	6.61e-05	20	56	3	MP:0001715
MousePheno	abnormal cell nucleus morphology	DDX12P SYNE2 BUB1 HDAC8 DDX11L8 DDX11	9.01e-05	184	56	6	MP:0003111
MousePheno	aneuploidy	DDX12P BUB1 DDX11L8 DDX11	1.02e-04	61	56	4	MP:0004024
MousePheno	abnormal amniotic cavity morphology	DDX12P DDX11L8 DDX11	1.32e-04	25	56	3	MP:0011199
MousePheno	abnormal chromosome morphology	DDX12P BUB1 HDAC8 DDX11L8 DDX11	1.45e-04	126	56	5	MP:0003702
MousePheno	decreased inner cell mass proliferation	DDX12P DDX11L8 STAT3 DDX11	1.65e-04	69	56	4	MP:0012113
MousePheno	abnormal cell cycle	RIF1 DDX12P BUB1 HAT1 CHD1 CHD2 GCN1 DDX11L8 DDX11	2.03e-04	520	56	9	MP:0003077
MousePheno	abnormal inner cell mass proliferation	DDX12P DDX11L8 STAT3 DDX11	2.05e-04	73	56	4	MP:0004966
MousePheno	abnormal mesenchyme morphology	DDX12P DDX11L8 DDX11 OVOL2	2.91e-04	80	56	4	MP:0006301
MousePheno	increased embryonic tissue cell apoptosis	DDX12P CHD1 DDX11L8 DDX11 OVOL2	3.58e-04	153	56	5	MP:0013504
MousePheno	wavy neural tube	DDX12P DDX11L8 DDX11	4.30e-04	37	56	3	MP:0000930
MousePheno	abnormal embryonic growth/weight/body size	RIF1 DDX12P ATAD3C HDAC8 ANKRD11 CHD1 GCN1 DDC DDX11L8 STAT3 RYR2 CHRNG DDX11 OVOL2	4.50e-04	1295	56	14	MP:0002088
MousePheno	abnormal germ layer morphology	DDX12P DDX11L8 STAT3 DDX11 OVOL2	4.53e-04	161	56	5	MP:0014138
MousePheno	abnormal paraxial mesoderm morphology	DDX12P DDX11L8 DDX11	5.42e-04	40	56	3	MP:0008029
MousePheno	abnormal prenatal growth/weight/body size	RIF1 DDX12P ATAD3C HDAC8 ANKRD11 CHD1 CHD2 GCN1 DDC DDX11L8 STAT3 RYR2 CHRNG DDX11 OVOL2	5.87e-04	1493	56	15	MP:0004196
MousePheno	absent somites	DDX12P DDX11L8 DDX11	6.26e-04	42	56	3	MP:0006386
MousePheno	failure of heart looping	DDX12P DDX11L8 DDX11	6.71e-04	43	56	3	MP:0004251
MousePheno	abnormal embryonic tissue cell apoptosis	DDX12P CHD1 DDX11L8 DDX11 OVOL2	7.52e-04	180	56	5	MP:0013503
Domain	Ribosomal_L26	RPL26 RPL26L1	1.42e-05	2	71	2	PF16906
Domain	Ribosomal_L26/L24P_euk/arc	RPL26 RPL26L1	1.42e-05	2	71	2	IPR005756
Domain	Ribosomal_L24/26_CS	RPL26 RPL26L1	4.26e-05	3	71	2	IPR005825
Domain	PHOSPHORYLASE	PYGL PYGM	4.26e-05	3	71	2	PS00102
Domain	DUF4208	CHD1 CHD2	4.26e-05	3	71	2	PF13907
Domain	Ryanrecept_TM4-6	RYR2 RYR3	4.26e-05	3	71	2	IPR009460
Domain	Phosphorylase	PYGL PYGM	4.26e-05	3	71	2	PF00343
Domain	Glycg_phsphrylas	PYGL PYGM	4.26e-05	3	71	2	IPR011833
Domain	RyR	RYR2 RYR3	4.26e-05	3	71	2	PF02026
Domain	Glyco_trans_35	PYGL PYGM	4.26e-05	3	71	2	IPR000811
Domain	Ryanodine_rcpt	RYR2 RYR3	4.26e-05	3	71	2	IPR003032
Domain	DUF4208	CHD1 CHD2	4.26e-05	3	71	2	SM01176
Domain	DUF4208	CHD1 CHD2	4.26e-05	3	71	2	IPR025260
Domain	RR_TM4-6	RYR2 RYR3	4.26e-05	3	71	2	PF06459
Domain	RIBOSOMAL_L24	RPL26 RPL26L1	4.26e-05	3	71	2	PS01108
Domain	Ryan_recept	RYR2 RYR3	4.26e-05	3	71	2	IPR013333
Domain	Chromo_domain	CHD9 CHD1 CHD2	1.01e-04	24	71	3	IPR023780
Domain	Chromo	CHD9 CHD1 CHD2	1.29e-04	26	71	3	PF00385
Domain	CHROMO_1	CHD9 CHD1 CHD2	1.61e-04	28	71	3	PS00598
Domain	CHROMO_2	CHD9 CHD1 CHD2	1.61e-04	28	71	3	PS50013
Domain	RIH_assoc	RYR2 RYR3	2.12e-04	6	71	2	PF08454
Domain	RIH_assoc-dom	RYR2 RYR3	2.12e-04	6	71	2	IPR013662
Domain	RIH_dom	RYR2 RYR3	2.12e-04	6	71	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 RYR3	2.12e-04	6	71	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 RYR3	2.12e-04	6	71	2	IPR015925
Domain	-	RYR2 RYR3	2.12e-04	6	71	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 RYR3	2.12e-04	6	71	2	PF01365
Domain	Ins145_P3_rec	RYR2 RYR3	2.12e-04	6	71	2	PF08709
Domain	SNF2_N	CHD9 CHD1 CHD2	2.41e-04	32	71	3	IPR000330
Domain	Chromodomain-like	CHD9 CHD1 CHD2	2.41e-04	32	71	3	IPR016197
Domain	SNF2_N	CHD9 CHD1 CHD2	2.41e-04	32	71	3	PF00176
Domain	Chromo/shadow_dom	CHD9 CHD1 CHD2	2.65e-04	33	71	3	IPR000953
Domain	CHROMO	CHD9 CHD1 CHD2	2.65e-04	33	71	3	SM00298
Domain	KOW	RPL26 RPL26L1	2.96e-04	7	71	2	SM00739
Domain	DNA/RNA_helicase_DEAH_CS	CHD1 CHD2 DDX11	3.16e-04	35	71	3	IPR002464
Domain	DEAH_ATP_HELICASE	CHD1 CHD2 DDX11	4.04e-04	38	71	3	PS00690
Domain	MIR	RYR2 RYR3	6.29e-04	10	71	2	PS50919
Domain	MIR	RYR2 RYR3	6.29e-04	10	71	2	PF02815
Domain	MIR	RYR2 RYR3	6.29e-04	10	71	2	SM00472
Domain	MIR_motif	RYR2 RYR3	6.29e-04	10	71	2	IPR016093
Domain	KOW	RPL26 RPL26L1	7.66e-04	11	71	2	IPR005824
Domain	KOW	RPL26 RPL26L1	7.66e-04	11	71	2	PF00467
Domain	Translation_prot_SH3-like	RPL26 RPL26L1	1.87e-03	17	71	2	IPR008991
Domain	Rib_L2_dom2	RPL26 RPL26L1	2.10e-03	18	71	2	IPR014722
Domain	Chromodomain_CS	CHD1 CHD2	2.10e-03	18	71	2	IPR023779
Domain	-	RPL26 RPL26L1	2.10e-03	18	71	2	2.30.30.30
Domain	SPRY	FBXO45 RYR2 RYR3	4.44e-03	87	71	3	SM00449
Domain	Spectrin_repeat	SYNE2 PPL	5.41e-03	29	71	2	IPR002017
Domain	SPRY	FBXO45 RYR2 RYR3	5.51e-03	94	71	3	PF00622
Domain	SPRY_dom	FBXO45 RYR2 RYR3	5.51e-03	94	71	3	IPR003877
Domain	B30.2/SPRY	FBXO45 RYR2 RYR3	5.68e-03	95	71	3	IPR001870
Domain	B302_SPRY	FBXO45 RYR2 RYR3	5.68e-03	95	71	3	PS50188
Domain	Spectrin/alpha-actinin	SYNE2 PPL	6.57e-03	32	71	2	IPR018159
Domain	SPEC	SYNE2 PPL	6.57e-03	32	71	2	SM00150
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION	PYGL PYGM G6PC2	5.46e-06	9	58	3	M47621
Pubmed	Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.	DDX12P DDX11L8 DDX11	8.87e-09	3	73	3	17611414
Pubmed	Mammalian ChlR1 has a role in heterochromatin organization.	DDX12P DDX11L8 DDX11	8.87e-09	3	73	3	21854770
Pubmed	The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.	DDX12P DDX11L8 DDX11	4.93e-07	8	73	3	22678773
Pubmed	Network organization of the human autophagy system.	RIF1 KBTBD6 HAT1 TAOK1 GCN1 NBR1 TBL2 ALDH7A1	3.84e-06	437	73	8	20562859
Pubmed	CHD1 and CHD2 are positive regulators of HIV-1 gene expression.	CHD1 CHD2	4.35e-06	2	73	2	25297984
Pubmed	Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.	RYR2 RYR3	4.35e-06	2	73	2	21531043
Pubmed	Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.	RYR2 RYR3	4.35e-06	2	73	2	16678258
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	4.35e-06	2	73	2	8898078
Pubmed	Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion.	DDX12P DDX11	4.35e-06	2	73	2	32855419
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	4.35e-06	2	73	2	14550562
Pubmed	Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA.	DDX12P DDX11	4.35e-06	2	73	2	8833153
Pubmed	Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.	RYR2 RYR3	4.35e-06	2	73	2	14985349
Pubmed	Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1.	DDX12P DDX11	4.35e-06	2	73	2	9013641
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPL26 NOP14 ATAD3C RPL26L1 SYNE2 CHD2 G6PC2 PTPN21 SPAG17 PPL RYR2 VAT1 DDX11	8.60e-06	1442	73	13	35575683
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RPL26 RIF1 XRN2 NOP14 SYNE2 PYGL CHD1 CHD2 GCN1	9.14e-06	653	73	9	22586326
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR2 RYR3	1.30e-05	3	73	2	18403125
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR2 RYR3	1.30e-05	3	73	2	18434746
Pubmed	Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.	RYR2 RYR3	1.30e-05	3	73	2	29730765
Pubmed	Activation of HDAC8 Can Suppress the Proliferation of Osteosarcoma Cells via TP53 and STAT3/ERK Signaling Pathways.	HDAC8 STAT3	1.30e-05	3	73	2	38182151
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR2 RYR3	1.30e-05	3	73	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR2 RYR3	1.30e-05	3	73	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR2 RYR3	1.30e-05	3	73	2	21881589
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR2 RYR3	1.30e-05	3	73	2	12213830
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR2 RYR3	1.30e-05	3	73	2	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR2 RYR3	1.30e-05	3	73	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR2 RYR3	1.30e-05	3	73	2	10788707
Pubmed	RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.	RYR2 RYR3	1.30e-05	3	73	2	15024040
Pubmed	HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.	HDAC8 STAT3	1.30e-05	3	73	2	25321483
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR2 RYR3	1.30e-05	3	73	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR2 RYR3	1.30e-05	3	73	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR2 RYR3	1.30e-05	3	73	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR2 RYR3	1.30e-05	3	73	2	11159936
Pubmed	The genomic and clinical landscape of fetal akinesia.	GCN1 RYR3	1.30e-05	3	73	2	31680123
Pubmed	Identification of putative phenotype-modifying genetic factors associated with phenotypic diversity in Brooke-Spiegler syndrome.	NBR1 STAT3	1.30e-05	3	73	2	32744342
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR2 RYR3	1.30e-05	3	73	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR2 RYR3	1.30e-05	3	73	2	7959768
Pubmed	CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.	CHD1 CHD2	1.30e-05	3	73	2	33022763
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR2 RYR3	1.30e-05	3	73	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR2 RYR3	1.30e-05	3	73	2	7635066
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	RHOG RPL26 XRN2 NOP14 AGPAT5 HAT1 PYGL TAOK1 CHD1 CHD2 GCN1 STAT3	1.81e-05	1318	73	12	30463901
Pubmed	Characterization of the CHD family of proteins.	CHD1 CHD2	2.60e-05	4	73	2	9326634
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR2 RYR3	2.60e-05	4	73	2	18206662
Pubmed	Comparison of the positional cloning methods used to isolate the BRCA1 gene.	NBR1 VAT1	2.60e-05	4	73	2	7581362
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR2 RYR3	2.60e-05	4	73	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR2 RYR3	2.60e-05	4	73	2	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR2 RYR3	2.60e-05	4	73	2	9607712
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR2 RYR3	2.60e-05	4	73	2	23482488
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	PYGL PYGM G6PC2	3.12e-05	29	73	3	32798765
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MTMR4 SYNE2 CHD9 GCN1	3.48e-05	87	73	4	12465718
Pubmed	Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.	HDAC8 PYGL CHD2	3.82e-05	31	73	3	14684825
Pubmed	Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.	RYR2 RYR3	4.33e-05	5	73	2	33060591
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR2 RYR3	4.33e-05	5	73	2	23918386
Pubmed	The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.	RIF1 CRMP1	4.33e-05	5	73	2	17118363
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR2 RYR3	4.33e-05	5	73	2	19011160
Pubmed	Analysis of mouse embryonic patterning and morphogenesis by forward genetics.	DDX12P DDX11L8 DDX11	4.63e-05	33	73	3	15755804
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	RPL26 RIF1 XRN2 DDX12P RPL26L1 HAT1 PYGL GCN1 TBL2 VAT1 DDX11	6.00e-05	1257	73	11	37317656
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR2 RYR3	6.48e-05	6	73	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR2 RYR3	6.48e-05	6	73	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR2 RYR3	6.48e-05	6	73	2	23463619
Pubmed	Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms.	HDAC8 STAT3	6.48e-05	6	73	2	23111066
Pubmed	Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells.	PLD1 STAT3	6.48e-05	6	73	2	22504301
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR2 RYR3	6.48e-05	6	73	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR2 RYR3	6.48e-05	6	73	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR2 RYR3	6.48e-05	6	73	2	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR2 RYR3	6.48e-05	6	73	2	19009018
Pubmed	Inhibition of Platelet GPVI Protects Against Myocardial Ischemia-Reperfusion Injury.	NBEAL2 PLD1	6.48e-05	6	73	2	26916731
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR2 RYR3	6.48e-05	6	73	2	16844763
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RHOG ZNF793 XRN2 DIS3L CHD9 TAOK1 TNKS2 LRP1B STAT3 RYR3 CRMP1	7.31e-05	1285	73	11	35914814
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	NBEAL2 ANKRD11 CHD9 TAOK1 CHD2 TBL2 RYR3	8.43e-05	497	73	7	36774506
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR2 RYR3	9.06e-05	7	73	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR2 RYR3	9.06e-05	7	73	2	20962236
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR2 RYR3	1.21e-04	8	73	2	19033399
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR2 RYR3	1.21e-04	8	73	2	11784029
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	RPL26 XRN2 MARCHF5 SYNE2 HAT1 PYGL GCN1 TBL2 PPL ALDH7A1 VAT1	1.26e-04	1367	73	11	32687490
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	RPL26 RPL26L1 SYNE2 CARS1 LRP1B TBL2	1.40e-04	375	73	6	32788342
Pubmed	A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.	NBR1 VAT1	1.55e-04	9	73	2	7545954
Pubmed	E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis.	ATAD3C PYGM STAT3 CRMP1	1.92e-04	135	73	4	29859926
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	RHOG RIF1 NOP14 AGPAT5 MARCHF5 HAT1 CHD1 CHD2 STAT3 VAT1	2.03e-04	1203	73	10	29180619
Pubmed	Meta-analysis identifies six new susceptibility loci for atrial fibrillation.	SYNE2 KCNN3	2.83e-04	12	73	2	22544366
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR2 RYR3	2.83e-04	12	73	2	19095005
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	RPL26 XRN2 NOP14 CARS1 NBR1	3.29e-04	283	73	5	28533407
Pubmed	RhoG signals in parallel with Rac1 and Cdc42.	RHOG PLD1	3.34e-04	13	73	2	12376551
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	XRN2 ODAD1 CHD2 GCN1 RYR3	3.35e-04	284	73	5	29459677
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	HDAC8 ANKRD11 HAT1 CHD2	3.41e-04	157	73	4	30186101
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RIF1 MTMR4 NOP14 SYNE2 PTPN21 STX17 GCN1 NBR1 VAT1	3.44e-04	1049	73	9	27880917
Pubmed	The functional interactome landscape of the human histone deacetylase family.	RIF1 SYNE2 HDAC8 ANKRD11 GCN1	3.62e-04	289	73	5	23752268
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	RPL26 XRN2 NOP14 NBR1	3.84e-04	162	73	4	31363146
Pubmed	NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.	STX17 NBR1	3.89e-04	14	73	2	31857374
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	RPL26 RIF1 XRN2 NOP14 RPL26L1 CHD1 PLD1 TBL2	3.98e-04	847	73	8	35850772
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	RIF1 ANKRD11 RYR2 RYR3	4.41e-04	168	73	4	30631154
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	RIF1 XRN2 NOP14 HAT1 GCN1 TBL2 STAT3	4.44e-04	653	73	7	33742100
Pubmed	Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively.	PYGL PYGM	4.48e-04	15	73	2	2575583
Pubmed	Germline genomic variants associated with childhood acute lymphoblastic leukemia.	DDC RYR2	4.48e-04	15	73	2	19684603
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	XRN2 SYNE2 CARS1 HAT1 PYGL GCN1	6.33e-04	498	73	6	36634849
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	RPL26 NOP14 RPL26L1 CHD1 TBL2	6.61e-04	330	73	5	33301849
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	RHOG XRN2 ATAD3C CARS1 GCN1 TBL2 DNAJC2	6.75e-04	701	73	7	30196744
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	RPL26 XRN2 NOP14 SLF1 ATAD3C RPL26L1 CHD9 CHD1 CHD2	6.78e-04	1153	73	9	29845934
Pubmed	Tagging genes with cassette-exchange sites.	RIF1 ZNF277 HSPBAP1 CARS1 TBL2	7.07e-04	335	73	5	15741177
Pubmed	Defining the membrane proteome of NK cells.	RPL26 XRN2 NOP14 NBEAL2 MARCHF5 BUB1 PLD1 GCN1 NBR1	7.44e-04	1168	73	9	19946888
Pubmed	Human transcription factor protein interaction networks.	RPL26 RIF1 XRN2 NOP14 SLF1 KBTBD6 DIS3L RPL26L1 SYNE2 STAT3	7.83e-04	1429	73	10	35140242
Cytoband	Ensembl 112 genes in cytogenetic band chr2q31	FASTKD1 HAT1 G6PC2	2.92e-03	178	73	3	chr2q31
Cytoband	Ensembl 112 genes in cytogenetic band chr10q23	MARCHF5 LIPJ TNKS2	3.77e-03	195	73	3	chr10q23
Cytoband	Ensembl 112 genes in cytogenetic band chr2q13	NPHP1 BUB1	4.02e-03	59	73	2	chr2q13
Cytoband	Ensembl 112 genes in cytogenetic band chr14q31	GPR65 PTPN21	4.02e-03	59	73	2	chr14q31
GeneFamily	Glycogen phosphorylases	PYGL PYGM	2.43e-05	3	52	2	437
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR2 RYR3	2.43e-05	3	52	2	287
GeneFamily	DNA helicases	CHD2 DDX11	1.07e-03	17	52	2	1167
Coexpression	XIE_TRASTUZUMAB_CARDIOTOXICITY_MMU_MIR_708_5P_GENES	DDX12P NBR1 DDX11L8 DDX11	1.07e-05	49	73	4	MM17508
Coexpression	GSE369_PRE_VS_POST_IL6_INJECTION_IFNG_WT_LIVER_DN	XRN2 TAOK1 CHD2 SLAMF1 DDC VAT1	2.04e-05	200	73	6	M5980
Coexpression	GSE8621_LPS_PRIMED_UNSTIM_VS_LPS_PRIMED_AND_LPS_STIM_MACROPHAGE_DN	RIF1 MTMR4 AGPAT5 PKD2L2 FASTKD1 TAOK1	2.04e-05	200	73	6	M6975
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-RGCs_early_2\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	ODAD1 ECM2 DYNLT5 PYGM FAM181B SPAG17	4.51e-07	176	73	6	8e0ac3ad5e47614b4befabd674a40e3eaae553f3
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 SYNE2 KCNN3 DYNLT5 SPAG17	8.71e-07	197	73	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RIF1 MTMR4 DIS3L SLC25A44 PPCS	9.64e-06	173	73	5	28c98a9a54aa2cfa67464db4f628c9357ad185b9
ToppCell	droplet-Spleen-nan-18m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPL26 XRN2 CHD9 CHD1 CHD2	1.23e-05	182	73	5	eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	RIF1 SYNE2 CHD9 TAOK1 CHD2	1.27e-05	183	73	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOP14 SYNE2 ANKRD11 CHD1 STAT3	1.40e-05	187	73	5	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SYNE2 ANKRD11 TAOK1 CHD1 CHD2	1.44e-05	188	73	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIF1 ANKRD11 G6PC2 TNKS2 DDC	1.72e-05	195	73	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 KCNN3 DYNLT5 SPAG17	1.94e-05	200	73	5	cc906ff02fd335ff633b3b97afceb670494f910a
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 KCNN3 DYNLT5 SPAG17	1.94e-05	200	73	5	79e59ab31d3d3385b1b072dc75508af9546c2e1b
ToppCell	LPS_only-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils\|LPS_only / Treatment groups by lineage, cell group, cell type	RHOG GPR65 NBEAL2 PYGL SLAMF1	1.94e-05	200	73	5	3504aeba7b30cac9c428ba3871c072e2202752b4
ToppCell	LPS_IL1RA-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	RHOG GPR65 NBEAL2 PYGL SLAMF1	1.94e-05	200	73	5	fd1b6db3c62f5a205b769ba0e61433dae6285b67
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 KCNN3 DYNLT5 SPAG17	1.94e-05	200	73	5	873def69bf55ccbfc944bc10c5afc06be019c312
ToppCell	LPS_IL1RA-Hematopoietic_Myeloid-Granulocytic_cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	RHOG GPR65 NBEAL2 PYGL SLAMF1	1.94e-05	200	73	5	0b7573ec4e9c67c7d11dd8f5011a70bade30e930
ToppCell	LPS_only-Hematopoietic_Myeloid-Granulocytic_cells\|LPS_only / Treatment groups by lineage, cell group, cell type	RHOG GPR65 NBEAL2 PYGL SLAMF1	1.94e-05	200	73	5	c5afebbc16024c60e84a67be81c78b0bfb73ec68
ToppCell	NS-critical-d_0-4-Myeloid-pDC\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ZIK1 AGPAT5 BUB1 KCNN3	9.23e-05	144	73	4	0fde5cd82df9b90aefde19275cff6c2ec3c9d5cb
ToppCell	droplet-Fat-Mat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOG GPR65 GPR34 PYGL	1.52e-04	164	73	4	baf6c40b004433c6b1d0bbbb74f73fcd6ee162ea
ToppCell	Ciliated_cells-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ODAD1 SPAG17 RYR3 CHRNG	1.52e-04	164	73	4	0e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKD2L2 BUB1 TBL2 PPL	1.52e-04	164	73	4	b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKD2L2 BUB1 TBL2 PPL	1.52e-04	164	73	4	a1e43c6b3e2553f5604100db6e92bf244b70c36d
ToppCell	droplet-Fat-Mat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOG GPR65 GPR34 PYGL	1.52e-04	164	73	4	1fc64b21e97e651f88a92de51536b3753f3e08d6
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZIK1 KCNN3 RYR2 VAT1	1.56e-04	165	73	4	6d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZIK1 KCNN3 RYR2 VAT1	1.56e-04	165	73	4	84f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|Liver / Manually curated celltypes from each tissue	ATAD3C KBTBD6 HDAC8 SLAMF1	1.60e-04	166	73	4	9afa33b5ad27dc33576be592f9b22d8161366838
ToppCell	Ciliated_cells-A-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	ODAD1 KCNN3 DYNLT5 SPAG17	1.63e-04	167	73	4	edb722ee9b6ccd00fb038f702be8664020932659
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Prlr_(Entorhinal_cortex?)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DYNLT5 SPAG17 PPL	1.67e-04	65	73	3	57d0d892dab8bc8465067feeff279c967a43b781
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Prlr_(Entorhinal_cortex?)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DYNLT5 SPAG17 PPL	1.67e-04	65	73	3	aba26f607f35c2920cdf956309285ad9e7b758a7
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 DYNLT5 SPAG17	1.71e-04	169	73	4	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKD2L2 DYNLT5 DDC CRMP1	1.71e-04	169	73	4	dbf9b1d52b29bf4b60bd23012cc1ea82d344747f
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SYNE2 CHD1 CHD2 STAT3	1.79e-04	171	73	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	normal_Lung-T/NK_cells-Exhausted_Tfh\|normal_Lung / Location, Cell class and cell subclass	NOP14 PLEKHN1 RYR2 CRMP1	1.87e-04	173	73	4	e8ead6c51c41dbd43c717ba9d1a7a0ab39c79330
ToppCell	droplet-Tongue-nan-24m-Myeloid-basal_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR65 GPR34 SLAMF1 CRMP1	2.08e-04	178	73	4	9423e209de94d26e96117581c95dc069850225d3
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ODAD1 KCNN3 DYNLT5 SPAG17	2.13e-04	179	73	4	5e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCell	droplet-Tongue-nan-24m-Myeloid-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR65 GPR34 SLAMF1 CRMP1	2.13e-04	179	73	4	1b079d80f789473701c781f3431ad306e9766797
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BUB1 KCNN3 CRMP1 DDX11	2.13e-04	179	73	4	df4d0b2fe47d2c7def729b3217cb01ced01495ff
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 DYNLT5 SPAG17	2.17e-04	180	73	4	1f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ATAD3C SLAMF1 PPL RYR2	2.17e-04	180	73	4	8e96f8646c002768b272359af485dc0ab57e0ccd
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR65 PPCS SLAMF1 ATP10A	2.22e-04	181	73	4	8a8061725e718c89a4c751a415120c5312acc757
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE2 PLEKHN1 SLAMF1 ATP10A	2.32e-04	183	73	4	a492b3827d2c368d33a7a5118748beaf4d7f6797
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPAG17 LRP1B RYR2 RYR3	2.36e-04	184	73	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XRN2 ANKRD11 CHD9 CHD1	2.36e-04	184	73	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPAG17 LRP1B RYR2 RYR3	2.36e-04	184	73	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPAG17 LRP1B RYR2 RYR3	2.36e-04	184	73	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Brain_organoid-organoid_Kanton_Nature\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	SLF1 MARCHF5 SYNE2 CHD9	2.41e-04	185	73	4	857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	NPHP1 ODAD1 DYNLT5 SPAG17	2.41e-04	185	73	4	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	mild-Myeloid-Immature_Neutrophils_1\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DYNLT5 PYGL PLD1 VAT1	2.41e-04	185	73	4	d747bc91fc276f12a5572ab0223fc71f829a5110
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KCNN3 PLD1 FAM181B LRP1B	2.46e-04	186	73	4	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NPHP1 ODAD1 DYNLT5 SPAG17	2.46e-04	186	73	4	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	tumor_Lung-Epithelial_cells-tS3\|Epithelial_cells / Location, Cell class and cell subclass	NPHP1 ODAD1 KCNN3 SPAG17	2.51e-04	187	73	4	3cea677279e71fdb9879530dea10a5e6393beacd
ToppCell	tumor_Lung-Epithelial_cells-tS3\|tumor_Lung / Location, Cell class and cell subclass	NPHP1 ODAD1 KCNN3 SPAG17	2.57e-04	188	73	4	26326b4e298e33f9ba393fc632238aa8c54b1ea3
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	SYNE2 PLEKHN1 STX17 ATP10A	2.57e-04	188	73	4	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-Myeloid-Mast_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RHOG GPR65 GPR34 DYNLT5	2.57e-04	188	73	4	3fe9d698ff8f540edebf8609e7d42d3f81271edb
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE2 ANKRD11 CHD1 CHD2	2.57e-04	188	73	4	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	NPHP1 SLF1 ODAD1 SPAG17	2.57e-04	188	73	4	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	COVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BUB1 KCNN3 SLAMF1 DDX11	2.57e-04	188	73	4	567b08514d9d84cbb40f9b7a679eec304f023428
ToppCell	normal_Lung-MAST_cells\|normal_Lung / Location, Cell class and cell subclass	RPL26 GPR65 GPR34 DYNLT5	2.62e-04	189	73	4	f09e387dc0626536050cd537dda212471a7267c4
ToppCell	normal_Lung-MAST_cells-MAST\|normal_Lung / Location, Cell class and cell subclass	RPL26 GPR65 GPR34 DYNLT5	2.62e-04	189	73	4	fd053209034fca6eaefe0e5ad024ac4548a100c9
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-MAIT\|lymph-node_spleen / Manually curated celltypes from each tissue	GPR65 SYNE2 PLD1 SLAMF1	2.62e-04	189	73	4	afe3a4fe7c10eeeb7064129778d940269c9acbef
ToppCell	PBMC-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	RIF1 SLF1 BUB1 HAT1	2.67e-04	190	73	4	84ee185939bdefb10705b621a70da27701eadcee
ToppCell	control-Myeloid-Immature_Neutrophils_1\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	KBTBD6 DYNLT5 PYGL PLD1	2.67e-04	190	73	4	38e83337c70c8734b63f8589ba59e0f98603f94c
ToppCell	ASK454-Epithelial-Ciliated\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	NPHP1 SLF1 SPAG17 SLAMF1	2.67e-04	190	73	4	5cea6480f08253d7adf484e511d3fdfa96641268
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Myeloid-Cd4_positive_Macrophages\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOP14 AGPAT5 DYNLT5 DNAJC2	2.72e-04	191	73	4	45023854f285ac465f23ea1b33c970e14992e709
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOP14 AGPAT5 DYNLT5 DNAJC2	2.72e-04	191	73	4	6890a8e4b4530987a5b044614fcd7e00716a4d66
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOP14 ECM2 CHD9 CHD1	2.78e-04	192	73	4	11088878043a6ff95ba1970361256a82e434b80a
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SYNE2 CHD1 CHD2 STAT3	2.78e-04	192	73	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHP1 NBEAL2 PPL VAT1	2.78e-04	192	73	4	44cb225392c8d07150955ecf203fbdf6021c9790
ToppCell	multiciliated\|World / shred by cell class for turbinate	NPHP1 CARS1 DYNLT5 SPAG17	2.78e-04	192	73	4	0f89ea0deb651ca11531c51ee94e0233608d22ea
ToppCell	15-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	ODAD1 DYNLT5 SPAG17 PPL	2.78e-04	192	73	4	9cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCell	ILEUM-inflamed-(1)_Tregs\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RHOG SYNE2 SLAMF1 STAT3	2.78e-04	192	73	4	1fe3417dfd1cf1758fd82c9ac13dbd88bdf0b548
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR34 CHD9 TAOK1 TNKS2	2.83e-04	193	73	4	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	Bronchial_Brush\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	NPHP1 ODAD1 DYNLT5 SPAG17	2.83e-04	193	73	4	3e693ac4c92576e3f2c9efdd3f1d96d3d336e260
ToppCell	distal-Hematologic-Basophil/Mast_2-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPR65 GPR34 BUB1 DYNLT5	2.83e-04	193	73	4	f22d0a2ea6bbdd625909ccb6a89aca89ab670306
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR34 CHD9 TAOK1 TNKS2	2.83e-04	193	73	4	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR34 CHD9 TAOK1 TNKS2	2.83e-04	193	73	4	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	distal-Hematologic-Basophil/Mast_2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPR65 GPR34 BUB1 DYNLT5	2.83e-04	193	73	4	dcdc1498726c68bf590bf84cb81e5f7fb7ba4d78
ToppCell	distal-3-Hematologic-Basophil/Mast_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPR65 GPR34 BUB1 DYNLT5	2.83e-04	193	73	4	23c6c798525dad43eff792727902ea562bf373be
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR34 CHD9 TAOK1 TNKS2	2.83e-04	193	73	4	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 CARS1 DYNLT5 SPAG17	2.89e-04	194	73	4	3cd90d01ed5a5ce65aad8284dab2537ec16e3d7c
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NPHP1 ODAD1 DYNLT5 SPAG17	2.89e-04	194	73	4	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 DYNLT5 SPAG17	2.89e-04	194	73	4	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 DYNLT5 SPAG17	2.95e-04	195	73	4	0e763f36786515698b593e5c93f6a56619c1242d
ToppCell	10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	GPR65 GPR34 RYR3 VAT1	2.95e-04	195	73	4	fbedb9978ded857fd35c2a8664f7579f42edaa36
ToppCell	distal-Hematologic-Basophil/Mast_1-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RPL26 GPR65 GPR34 DYNLT5	2.95e-04	195	73	4	5aab51a1e6842f2a397926e451133a67467fc614
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 DYNLT5 SPAG17	2.95e-04	195	73	4	581b04220587e1d5198b1abd6965965ace7803e7
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 DYNLT5 SPAG17	2.95e-04	195	73	4	93b1559382a12cfb158aa5fac7386e38b4f87989
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPR65 AGPAT5 ATP10A STAT3	2.95e-04	195	73	4	69201b1172bcf0999c726516e4d30863afceab0b
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 ODAD1 DYNLT5 SPAG17	2.95e-04	195	73	4	79dc031258579ea328181dda33710dd897f1064a
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHP1 CARS1 DYNLT5 SPAG17	2.95e-04	195	73	4	db4270c135c392ed443670981656e3cd5b95939d
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	NPHP1 ODAD1 DYNLT5 SPAG17	2.95e-04	195	73	4	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	NPHP1 ODAD1 DYNLT5 SPAG17	2.95e-04	195	73	4	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	severe-Myeloid-Immature_Neutrophils_1\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	KBTBD6 PYGL PLD1 VAT1	2.95e-04	195	73	4	becad890a420267ca41e98e61a8da343b51e1945
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIF1 ANKRD11 G6PC2 DDC	2.95e-04	195	73	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOP14 ECM2 CHD9 CHD1	2.95e-04	195	73	4	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	distal-3-Hematologic-Basophil/Mast_1\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RPL26 GPR65 GPR34 DYNLT5	2.95e-04	195	73	4	009986b5b32a7df3bdbe6cc1adf48023060f454f
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	NPHP1 ODAD1 DYNLT5 SPAG17	3.01e-04	196	73	4	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	NS-moderate-d_07-13-Epithelial-Ciliated-diff\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NPHP1 ODAD1 DYNLT5 SPAG17	3.01e-04	196	73	4	9a91a6e5f93ce3bb5a0fc63677553f4c2df95c43
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NPHP1 ODAD1 DYNLT5 SPAG17	3.01e-04	196	73	4	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NPHP1 ODAD1 DYNLT5 SPAG17	3.06e-04	197	73	4	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_prolif\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RHOG RPL26 GPR34 PYGL	3.06e-04	197	73	4	61f2c420b77d0527d57532172b07bfb7a4cf971a
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NPHP1 ODAD1 DYNLT5 SPAG17	3.06e-04	197	73	4	71fea4aa6ce96c7693fa94792d08770622873850
Drug	Gvapspat amide	PYGL PYGM RYR2 RYR3	1.15e-07	15	71	4	CID000125015
Drug	etafenone	PYGL PYGM ALDH7A1	2.89e-07	5	71	3	CID000003275
Drug	2',3'-dideoxy-3'-fluorocytidine	PYGL PYGM DDC	1.01e-06	7	71	3	CID000356019
Drug	Etafenone [inn]	PYGL PYGM ALDH7A1	1.61e-06	8	71	3	CID000066659
Drug	1-N-Acetyl-Beta-D-Glucosamine	PYGL PYGM	9.59e-06	2	71	2	DB02320
Drug	3,5-dimethylphenyl isocyanate	PYGL PYGM	2.87e-05	3	71	2	CID000521488
Drug	5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone	PYGL PYGM	2.87e-05	3	71	2	CID000093111
Drug	adenosine-5'-chloromethylphosphonate	PYGL PYGM	2.87e-05	3	71	2	CID000191554
Drug	hydan	PYGL PYGM	2.87e-05	3	71	2	CID000008360
Drug	EHMF	PYGL PYGM	2.87e-05	3	71	2	CID000033931
Drug	2-hydroxycarbazole	RYR2 RYR3	2.87e-05	3	71	2	CID000093551
Drug	5'-deoxy-5'-fluoro-5'-(methylthio)adenosine	PYGL PYGM	2.87e-05	3	71	2	CID000147839
Drug	pyridoxal 5'-methylenephosphonate	PYGL PYGM	2.87e-05	3	71	2	CID003082249
Drug	Plp 5'-mpa	PYGL PYGM	2.87e-05	3	71	2	CID003082151
Drug	cis-diammineplatinum(II	RYR2 RYR3	2.87e-05	3	71	2	CID000159790
Drug	glucose-1,2-cyclic phosphate	PYGL PYGM	2.87e-05	3	71	2	CID000191723
Drug	3'-FFdUrd	PYGL PYGM	2.87e-05	3	71	2	CID000072260
Drug	2-hydroxyheptanoic acid	RYR2 RYR3	2.87e-05	3	71	2	CID002750949
Drug	2',3',4',5,5'-pentachloro-2-biphenylol	PYGL PYGM	2.87e-05	3	71	2	CID000119518
Drug	AC1L8XK3	PYGL PYGM	2.87e-05	3	71	2	CID000409735
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR2 RYR3	2.87e-05	3	71	2	CID005748312
Drug	8N3-cADPR	RYR2 RYR3	2.87e-05	3	71	2	CID000127713
Drug	N-acetyl-N'-beta-D-glucopyranosyl urea	PYGL PYGM	2.87e-05	3	71	2	CID000446801
Drug	NSC758405	PYGL PYGM	2.87e-05	3	71	2	CID000003201
Drug	aminodantrolene	RYR2 RYR3	2.87e-05	3	71	2	CID009570289
Drug	3,5-dinitrophenyl phosphate	PYGL PYGM	2.87e-05	3	71	2	CID000151920
Drug	riboflavin tetraacetate	PYGL PYGM	2.87e-05	3	71	2	CID000094186
Drug	pyridoxal phosphoglucose	PYGL PYGM	2.87e-05	3	71	2	CID000196007
Drug	2,5-dimethyl-3-furanone	PYGL PYGM	2.87e-05	3	71	2	CID000085730
Drug	3,5-dinitrophenol	PYGL PYGM	2.87e-05	3	71	2	CID000011459
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; PC3; HT_HG-U133A	RIF1 ZNF277 ECM2 PLD1 PTPN21 ATP10A	3.59e-05	198	71	6	3755_UP
Drug	4-pyridoxic acid	PYGL PYGM PPL	4.92e-05	23	71	3	CID000006723
Drug	galocitabine	PYGL PYGM	5.73e-05	4	71	2	CID000065950
Drug	2,5-anhydro-D-mannitol 1-phosphate	PYGL PYGM	5.73e-05	4	71	2	CID000189134
Drug	AC1LAMW2	PYGL PYGM	5.73e-05	4	71	2	CID000491364
Drug	FdUrd-C8	PYGL PYGM	5.73e-05	4	71	2	CID000094262
Drug	Mem-CC	PYGL PYGM	5.73e-05	4	71	2	CID003081269
Drug	PCB74	RYR2 RYR3	5.73e-05	4	71	2	CID000036218
Drug	5-deoxyribose-1-phosphate	PYGL PYGM	5.73e-05	4	71	2	CID000135786
Drug	148504-47-6	RYR2 RYR3	5.73e-05	4	71	2	CID006444275
Drug	ingliforib	PYGL PYGM	5.73e-05	4	71	2	CID006451325
Drug	uric acid riboside	PYGL PYGM	5.73e-05	4	71	2	CID000164933
Drug	pseudo-dl-glucose	PYGL PYGM	5.73e-05	4	71	2	CID000125259
Drug	SC 38249	RYR2 RYR3	5.73e-05	4	71	2	CID000134834
Drug	AC1L1U7A	RYR2 RYR3	5.73e-05	4	71	2	CID000035682
Drug	BCIp4A	PYGL PYGM	5.73e-05	4	71	2	CID000192417
Drug	pyridoxal diphosphate	PYGL PYGM	5.73e-05	4	71	2	CID000125696
Drug	3'-chloromethotrexate	PYGL PYGM	5.73e-05	4	71	2	CID000097703
Drug	heptulose-2-P	PYGL PYGM	9.53e-05	5	71	2	CID000124823
Drug	m-anisidine	PYGL PYGM	9.53e-05	5	71	2	CID000010824
Drug	6-FPLP	PYGL PYGM	9.53e-05	5	71	2	CID000146246
Drug	gluconohydroximo-1,5-lactone	PYGL PYGM	9.53e-05	5	71	2	CID009576855
Drug	2-hydroxypropylphosphonate	PYGL PYGM	9.53e-05	5	71	2	CID000441028
Drug	DHPBU	PYGL PYGM	9.53e-05	5	71	2	CID000125914
Drug	6-FDPL	PYGL PYGM	9.53e-05	5	71	2	CID000129578
Drug	5'-isobutylthioinosine	PYGL PYGM	9.53e-05	5	71	2	CID003080910
Drug	3'-O-methylpyridoxal 5'-phosphate	PYGL PYGM	9.53e-05	5	71	2	CID003082179
Drug	GlcMan	PYGL PYGM	9.53e-05	5	71	2	CID000152120
Drug	U66985	PYGL PYGM	9.53e-05	5	71	2	CID000127224
Drug	indirubin-5-sulphonate	PYGL PYGM	9.53e-05	5	71	2	CID005288641
Drug	AC1O3M08	PYGL PYGM	9.53e-05	5	71	2	CID006331955
Drug	AC1LCUXJ	PYGL PYGM	9.53e-05	5	71	2	CID000656425
Drug	6-amino-5-bromouracil	PYGL PYGM	9.53e-05	5	71	2	CID000080578
Drug	ddEtUrd	PYGL PYGM	9.53e-05	5	71	2	CID000451452
Drug	5-trifluoromethyl-2'-deoxycytidine	PYGL PYGM	9.53e-05	5	71	2	CID000125618
Drug	M-HN	ALDH7A1 RYR2 RYR3	1.23e-04	31	71	3	CID000015450
Drug	CV-araU	PYGL PYGM	1.43e-04	6	71	2	CID006441877
Drug	2-thiothymidine	PYGL PYGM	1.43e-04	6	71	2	CID003005944
Drug	Carbocyclic Bvdc	PYGL PYGM	1.43e-04	6	71	2	CID006438602
Drug	DNPP	PYGL PYGM	1.43e-04	6	71	2	CID000067056
Drug	MBED	RYR2 RYR3	1.43e-04	6	71	2	CID000129958
Drug	5-chloro-indole-2-carboxylic acid	PYGL PYGM	1.43e-04	6	71	2	CID000082693
Drug	chloro-m-cresol	RYR2 RYR3	1.43e-04	6	71	2	CID000012008
Drug	2,2-dimethyl-3-hydroxybutyric acid	PYGL PYGM	1.43e-04	6	71	2	CID000152984
Drug	EdUMP	PYGL PYGM	1.43e-04	6	71	2	CID003085112
Drug	4-hydroxyacetophenone	PYGL PYGM	1.43e-04	6	71	2	ctd:C031335
Drug	5'-deoxy-5'-chloroformycin	PYGL PYGM	1.43e-04	6	71	2	CID000126430
Drug	AC1O528X	RYR2 RYR3	1.43e-04	6	71	2	CID006475857
Drug	NSC-97433	PYGL PYGM	1.43e-04	6	71	2	CID000001803
Drug	5-n-propylthioadenosine	PYGL PYGM	1.43e-04	6	71	2	CID000656428
Drug	AzddCyd	PYGL PYGM	1.43e-04	6	71	2	CID000451374
Drug	5-Ffdru	PYGL PYGM	1.43e-04	6	71	2	CID000065561
Drug	AR-L57	PYGL PYGM	1.43e-04	6	71	2	CID000156890
Drug	Carbocyclic Ivdu	PYGL PYGM	1.43e-04	6	71	2	CID006439191
Drug	NSC114784	RYR2 RYR3	1.43e-04	6	71	2	CID000419425
Drug	alpha-(fluoromethyl)dehydroornithine	PYGL PYGM	1.99e-04	7	71	2	CID006439607
Drug	2,4-Dbe	CARS1 G6PC2	1.99e-04	7	71	2	CID000007206
Drug	Azumoleno	RYR2 RYR3	1.99e-04	7	71	2	CID000056259
Drug	6-fluoropyridoxal	PYGL PYGM	1.99e-04	7	71	2	CID003080803
Drug	l 1400	KCNN3 ALDH7A1	1.99e-04	7	71	2	CID000015548
Drug	heptenitol	PYGL PYGM	1.99e-04	7	71	2	CID000188267
Drug	AC1L3372	PYGL PYGM	1.99e-04	7	71	2	CID000108025
Drug	Br2BAPTA	RYR2 RYR3	1.99e-04	7	71	2	CID003081001
Drug	1 Gpt	PYGL PYGM	1.99e-04	7	71	2	CID000101247
Drug	formycins	PYGL PYGM	1.99e-04	7	71	2	CID000512867
Drug	Promonta	PYGL PYGM	1.99e-04	7	71	2	CID000108494
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR2 RYR3	1.99e-04	7	71	2	CID009547999
Drug	5'-methylthioinosine	PYGL PYGM	1.99e-04	7	71	2	CID000161214
Drug	hydantocidin	PYGL PYGM	1.99e-04	7	71	2	CID000125429
Drug	I TU	PYGL PYGM ALDH7A1	2.09e-04	37	71	3	CID000001830
Disease	Warsaw breakage syndrome (implicated_via_orthology)	DDX12P DDX11L8 DDX11	1.39e-08	3	72	3	DOID:0060535 (implicated_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR2 RYR3	1.76e-05	3	72	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR2 RYR3	1.76e-05	3	72	2	DOID:8545 (implicated_via_orthology)
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD2	1.22e-04	7	72	2	DOID:0050834 (implicated_via_orthology)
Disease	blindness (implicated_via_orthology)	RPL26 RPL26L1	1.63e-04	8	72	2	DOID:1432 (implicated_via_orthology)
Disease	velopharyngeal dysfunction	PDILT FBXO45 PPL CRMP1	2.30e-04	122	72	4	EFO_0009336
Disease	autism spectrum disorder (implicated_via_orthology)	CHD9 TAOK1 CHD1 CHD2	5.30e-04	152	72	4	DOID:0060041 (implicated_via_orthology)
Disease	acute lymphoblastic leukemia	PYGL DDC RYR2	5.71e-04	66	72	3	EFO_0000220
Disease	Autism Spectrum Disorders	ANKRD11 CHD2 RYR2	1.19e-03	85	72	3	C1510586
Disease	Glycogen Storage Disease	PYGL PYGM	1.98e-03	27	72	2	C0017919
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement	KCNN3 DDX11	2.28e-03	29	72	2	EFO_0004735, EFO_0004736

Protein segments in the cluster

Peptide	Gene	Start	Entry
AANNGHYKVVKLLLR	ANKRD11	241	Q6UB99
KVFQQHYTNKIRALR	BUB1	1056	O43683
VVNRLKKAYAQIRVG	ALDH7A1	346	P49419
AGHQKVVFYLLIQRK	CHRNG	226	P07510
YKLIVIVHIGQLNRQ	DYNLT5	126	Q8N7M0
GIHRKRNSIQIYLLN	GPR34	81	Q9UPC5
VKGLQAYIRKHVQLS	DDC	371	P20711
ARAHRIGQKKQVNIY	CHD1	896	O14646
GHVRYKATQRQIKAA	DNAJC2	96	Q99543
GRHQKKIRSKTQNYL	ATP10A	786	O60312
IFYKRIHGREKRQAN	LRP1B	3946	Q9NZR2
KNLAQRVVVYLQHGL	LIPJ	41	Q5W064
RKNQNIGYKLGHRRA	KCNN3	261	Q9UGI6
KERVTNLRGKHKQIY	PPL	111	O60437
NLRGKHKQIYRLAVK	PPL	116	O60437
TNIGLYEKRIQQHKL	FAM214A	231	Q32MH5
FKQQQYLRQAHRKIL	MARCHF5	256	Q9NX47
RLTGNKVQQYHRALV	GCN1	556	Q92616
VNHRKYLQKQIKRCS	FAM181B	91	A6NEQ2
KIHGVQQQYAYKQRR	OVOL2	196	Q9BRP0
QLQHRVQLKYAAKRL	DDX11	146	Q96FC9
VNRQKFQILGRKTRH	NOP14	36	P78316
RAYSKEVHQRINKQL	ODAD1	6	Q96M63
IQHRLRQIEAGYKQE	MTMR4	1021	Q9NYA4
QKVALLHQKYRGLTA	PTPN21	186	Q16825
NRARKALEIYQHQVV	PPCS	241	Q9HAB8
KYLSQVLHGKQIRFR	HSPBAP1	61	Q96EW2
RCHRIGQNKAVKVYR	CHD9	1291	Q3L8U1
FKINKQHARRVYEIL	HAT1	321	O14929
AHRIGQKKQVNIYRL	CHD2	901	O14647
RNVYIKKNGFTLHRN	FBXO45	121	P0C2W1
GRYIQGILNVNKHRA	DIS3L	241	Q8TF46
QLQHRVQLKYAAKRL	DDX11L8	146	A8MPP1
QLKLLQKLDHYGRQR	FASTKD1	476	Q53R41
ERLQQLQHRVQLKYA	DDX12P	161	Q92771
RNIKKNRGLYRHILL	ATAD3C	161	Q5T2N8
RNGVLIIQHLQKDYR	G6PC2	6	Q9NQR9
NHTRKINVIVLRYNK	ECM2	506	O94769
RIQQILNYIKGNLKH	HDAC8	361	Q9BY41
KQKLLYQQARLHDRG	RYR2	3721	Q92736
EHLYQRVKIRNKVFG	CRMP1	476	Q14194
TNNYRIIKHGQKLLL	KBTBD6	556	Q86V97
KRQHIYQRCIQLKQA	NPHP1	41	O15259
HYKGQQIGKVVQVYR	RPL26L1	61	Q9UNX3
GRKYQNHSTIIIAKI	PDILT	431	Q8N807
RNLGKVVHYAKVQLR	PLEKHN1	91	Q494U1
KIIKRARQNHLFEQY	CARS1	101	P49589
YQQIKRNIGGKHARL	SYNE2	4881	Q8WXH0
LRLLKKHNYNILQVV	NBR1	936	Q14596
IAQRILKAHRENQKY	PLD1	801	Q13393
QGQALAKQIHAVRYL	RHOG	141	P84095
KALRIYHEQQVKTRG	RIF1	2356	Q5UIP0
EHRQKLRKKYGVQFI	NBEAL2	1051	Q6ZNJ1
VILQLRRRGKTNHYQ	SLAMF1	256	Q13291
KIQTRQYKALRNHLL	TAOK1	731	Q7L7X3
IRTRLQVQKGKSLYH	SLC25A44	41	Q96H78
KVLLQVLQEAHKQYR	SPAG17	791	Q6Q759
QKIHARKNAYRNENL	ZNF793	386	Q6ZN11
AVKRNVRKIILHENY	TMPRSS11F	271	Q6ZWK6
IQVKRIHEYKRQLLN	PYGM	566	P11217
KQKTLYQQARLHERG	RYR3	3611	Q15413
RLRKHQINIEKYQRC	STX17	31	P56962
NVLYQHNLRRIKQFL	STAT3	76	P40763
HYKGQQIGKVVQVYR	RPL26	61	P61254
KAFRGKYSLVQHQRV	ZIK1	246	Q3SY52
DRLVNIYKNVVHKTG	XRN2	361	Q9H0D6
ELHYINLKLNQVVRK	PKD2L2	606	Q9NZM6
ICNRKVYQAVRHNKA	GPR65	201	Q8IYL9
VEIKNTLRKHIYRAQ	SLF1	371	Q9BQI6
HLAAGYNRVKIVQLL	TNKS2	216	Q9H2K2
YNRVKIVQLLLQHGA	TNKS2	221	Q9H2K2
VVARLLALYNQGHIK	VAT1	341	Q99536
YQQVKLVNFIRRQVH	ZNF277	341	Q9NRM2
AIRQNALGHVRYVLK	AGPAT5	106	Q9NUQ2
VQVKRIHEYKRQLLN	PYGL	566	P06737
QKQYQRIRKEKPQQH	TBL2	61	Q9Y4P3