Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	FUT3 FUT4 FUT5 FUT6	7.16e-09	6	95	4	GO:0017083
GeneOntologyMolecularFunction	alpha-(1->3)-fucosyltransferase activity	FUT3 FUT4 FUT5 FUT6	3.32e-08	8	95	4	GO:0046920
GeneOntologyMolecularFunction	fucosyltransferase activity	FUT3 FUT4 FUT5 FUT6	4.64e-07	14	95	4	GO:0008417
GeneOntologyMolecularFunction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	FUT3 FUT5	2.24e-05	2	95	2	GO:0017060
GeneOntologyMolecularFunction	ATP-dependent activity	ACSM1 ATP8B2 CHD5 DDX60L MYO15A ATP2A2 ATP2A3 DNAH8 DNAH9 SLC27A5 MOV10	1.60e-04	614	95	11	GO:0140657
GeneOntologyMolecularFunction	polysaccharide binding	CLEC18A CLEC18B CLEC18C	4.26e-04	31	95	3	GO:0030247
GeneOntologyBiologicalProcess	fucosylation	FUT3 FUT4 FUT5 FUT6	1.13e-06	18	93	4	GO:0036065
GeneOntologyBiologicalProcess	L-fucose catabolic process	FUT4 FUT5 FUT6	7.31e-06	9	93	3	GO:0042355
GeneOntologyBiologicalProcess	fucose catabolic process	FUT4 FUT5 FUT6	7.31e-06	9	93	3	GO:0019317
GeneOntologyBiologicalProcess	L-fucose metabolic process	FUT4 FUT5 FUT6	1.04e-05	10	93	3	GO:0042354
GeneOntologyBiologicalProcess	oligosaccharide biosynthetic process	FUT3 FUT4 FUT5 FUT6	1.11e-05	31	93	4	GO:0009312
GeneOntologyBiologicalProcess	sphingolipid metabolic process	ELOVL4 PRKD3 SMPD1 FUT3 FUT4 FUT5 FUT6	1.49e-05	176	93	7	GO:0006665
GeneOntologyBiologicalProcess	calcium ion transport from cytosol to endoplasmic reticulum	ATP2A2 ATP2A3	2.01e-05	2	93	2	GO:1903515
GeneOntologyBiologicalProcess	fucose metabolic process	FUT4 FUT5 FUT6	4.76e-05	16	93	3	GO:0006004
GeneOntologyBiologicalProcess	membrane lipid metabolic process	ELOVL4 PRKD3 SMPD1 FUT3 FUT4 FUT5 FUT6	8.00e-05	229	93	7	GO:0006643
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	ELOVL4 PRKD3 SMPD1 FUT4 FUT6	1.88e-04	117	93	5	GO:0030148
GeneOntologyBiologicalProcess	cytosol to endoplasmic reticulum transport	ATP2A2 ATP2A3	1.99e-04	5	93	2	GO:0046967
GeneOntologyBiologicalProcess	oligosaccharide metabolic process	FUT3 FUT4 FUT5 FUT6	2.83e-04	70	93	4	GO:0009311
GeneOntologyCellularComponent	Golgi cisterna	HLA-H SORT1 FUT3 FUT4 FUT5 FUT6	3.12e-05	135	93	6	GO:0031985
GeneOntologyCellularComponent	Golgi cisterna membrane	SORT1 FUT3 FUT4 FUT5 FUT6	6.28e-05	94	93	5	GO:0032580
GeneOntologyCellularComponent	Golgi stack	HLA-H SORT1 FUT3 FUT4 FUT5 FUT6	1.16e-04	171	93	6	GO:0005795
GeneOntologyCellularComponent	microvillus membrane	SLC34A2 IZUMO1R PTPRH	6.42e-04	38	93	3	GO:0031528
GeneOntologyCellularComponent	platelet dense tubular network membrane	ATP2A2 ATP2A3	6.91e-04	9	93	2	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ATP2A2 ATP2A3	1.05e-03	11	93	2	GO:0031094
GeneOntologyCellularComponent	outer dynein arm	DNAH8 DNAH9	1.26e-03	12	93	2	GO:0036157
HumanPheno	Decreased pulmonary function	SLC34A2 PIK3CA SMPD1	4.10e-05	13	28	3	HP:0005952
HumanPheno	Progressive pulmonary function impairment	SLC34A2 PIK3CA SMPD1	4.10e-05	13	28	3	HP:0006520
Domain	Glyco_transf_10	FUT3 FUT4 FUT5 FUT6	3.17e-08	8	88	4	PF00852
Domain	Glyco_tran_10_N	FUT3 FUT4 FUT5 FUT6	3.17e-08	8	88	4	PF17039
Domain	Glyco_trans_10	FUT3 FUT4 FUT5 FUT6	3.17e-08	8	88	4	IPR001503
Domain	Glyco_tran_10_N	FUT3 FUT4 FUT5 FUT6	3.17e-08	8	88	4	IPR031481
Domain	-	CLEC18A CLEC18B CLEC18C	4.41e-05	15	88	3	3.40.33.10
Domain	CAP	CLEC18A CLEC18B CLEC18C	4.41e-05	15	88	3	PF00188
Domain	CAP_domain	CLEC18A CLEC18B CLEC18C	4.41e-05	15	88	3	IPR014044
Domain	SCP	CLEC18A CLEC18B CLEC18C	4.41e-05	15	88	3	SM00198
Domain	Allrgn_V5/Tpx1	CLEC18A CLEC18B CLEC18C	4.41e-05	15	88	3	IPR001283
Domain	P-type_ATPase_IIA	ATP2A2 ATP2A3	6.56e-05	3	88	2	IPR005782
Domain	-	ATP8B2 ATP2A2 ATP2A3	4.54e-04	32	88	3	3.40.1110.10
Domain	-	ATP8B2 ATP2A2 ATP2A3	4.54e-04	32	88	3	2.70.150.10
Domain	C2	RGS3 PIK3CA PLA2G4F FER1L5 RASAL1	4.75e-04	137	88	5	SM00239
Domain	C2	RGS3 PIK3CA PLA2G4F FER1L5 RASAL1	5.59e-04	142	88	5	PS50004
Domain	ATPase_P-typ_cyto_domN	ATP8B2 ATP2A2 ATP2A3	5.93e-04	35	88	3	IPR023299
Domain	DHC_N1	DNAH8 DNAH9	6.03e-04	8	88	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH8 DNAH9	6.03e-04	8	88	2	IPR013594
Domain	P_typ_ATPase	ATP8B2 ATP2A2 ATP2A3	6.45e-04	36	88	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP8B2 ATP2A2 ATP2A3	6.45e-04	36	88	3	IPR018303
Domain	ATPASE_E1_E2	ATP8B2 ATP2A2 ATP2A3	6.45e-04	36	88	3	PS00154
Domain	-	RGS3 PIK3CA PLA2G4F FER1L5 RASAL1	6.74e-04	148	88	5	2.60.40.150
Domain	ATPase_P-typ_transduc_dom_A	ATP8B2 ATP2A2 ATP2A3	6.99e-04	37	88	3	IPR008250
Domain	E1-E2_ATPase	ATP8B2 ATP2A2 ATP2A3	6.99e-04	37	88	3	PF00122
Domain	Hydrolase_3	ATP2A2 ATP2A3	9.64e-04	10	88	2	PF08282
Domain	C2_dom	RGS3 PIK3CA PLA2G4F FER1L5 RASAL1	1.07e-03	164	88	5	IPR000008
Domain	C-type_lectin_CS	CLEC18A CLEC18B CLEC18C	1.09e-03	43	88	3	IPR018378
Domain	Dynein_heavy_chain_D4_dom	DNAH8 DNAH9	1.93e-03	14	88	2	IPR024317
Domain	Dynein_HC_stalk	DNAH8 DNAH9	1.93e-03	14	88	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH8 DNAH9	1.93e-03	14	88	2	IPR013602
Domain	DHC_N2	DNAH8 DNAH9	1.93e-03	14	88	2	PF08393
Domain	MT	DNAH8 DNAH9	1.93e-03	14	88	2	PF12777
Domain	AAA_8	DNAH8 DNAH9	1.93e-03	14	88	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH8 DNAH9	1.93e-03	14	88	2	IPR011704
Domain	AAA_5	DNAH8 DNAH9	1.93e-03	14	88	2	PF07728
Domain	p53-like_TF_DNA-bd	FUT3 FUT5 FUT6	2.00e-03	53	88	3	IPR008967
Domain	DHC_fam	DNAH8 DNAH9	2.21e-03	15	88	2	IPR026983
Domain	Dynein_heavy_dom	DNAH8 DNAH9	2.21e-03	15	88	2	IPR004273
Domain	Dynein_heavy	DNAH8 DNAH9	2.21e-03	15	88	2	PF03028
Domain	-	ATP2A2 ATP2A3	2.52e-03	16	88	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP2A2 ATP2A3	2.52e-03	16	88	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP2A2 ATP2A3	2.85e-03	17	88	2	IPR006068
Domain	Cation_ATPase_C	ATP2A2 ATP2A3	2.85e-03	17	88	2	PF00689
Domain	Acyl_Trfase/lysoPLipase	PNPLA5 PLA2G4F	2.85e-03	17	88	2	IPR016035
Domain	AMP-bd_C	ACSM1 SLC27A5	2.85e-03	17	88	2	IPR025110
Domain	AMP-binding_C	ACSM1 SLC27A5	2.85e-03	17	88	2	PF13193
Domain	Cation_ATPase_N	ATP2A2 ATP2A3	3.20e-03	18	88	2	PF00690
Domain	Cation_ATPase_N	ATP2A2 ATP2A3	3.20e-03	18	88	2	SM00831
Domain	C2	RGS3 PLA2G4F FER1L5 RASAL1	3.42e-03	131	88	4	PF00168
Domain	ATPase_P-typ_cation-transptr_N	ATP2A2 ATP2A3	3.56e-03	19	88	2	IPR004014
Pathway	KEGG_MEDICUS_REFERENCE_LEWIS_X_ANTIGEN_BIOSYNTHESIS	FUT3 FUT4 FUT5 FUT6	1.69e-09	5	62	4	M47966
Pathway	KEGG_MEDICUS_REFERENCE_SIALYL_LEWIS_X_ANTIGEN_BIOSYNTHESIS	FUT3 FUT4 FUT5 FUT6	5.05e-09	6	62	4	M47967
Pathway	REACTOME_BLOOD_GROUP_SYSTEMS_BIOSYNTHESIS	FUT3 FUT4 FUT5 FUT6	1.92e-06	21	62	4	M27917
Pathway	KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES	FUT3 FUT4 FUT5 FUT6	4.72e-06	26	62	4	M17377
Pathway	BIOCARTA_AMAN_PATHWAY	FUT4 FUT5 FUT6	3.55e-05	15	62	3	M22009
Pathway	WP_FOLATE_METABOLISM	CAT IZUMO1R MTHFR FLAD1	2.37e-04	69	62	4	M39617
Pubmed	Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.	FUT3 FUT4 FUT5 FUT6	3.21e-10	5	100	4	29593094
Pubmed	Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.	FUT3 FUT5 FUT6	2.31e-08	3	100	3	7650030
Pubmed	Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.	CLEC18A CLEC18B CLEC18C	2.31e-08	3	100	3	26170455
Pubmed	Overexpressed N-fucosylation on the cell surface driven by FUT3, 5, and 6 promotes cell motilities in metastatic pancreatic cancer cell lines.	FUT3 FUT5 FUT6	2.31e-08	3	100	3	30808544
Pubmed	Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21.	FUT4 FUT5 FUT6	2.31e-08	3	100	3	7782074
Pubmed	Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities.	FUT3 FUT4 FUT5	2.31e-08	3	100	3	1740457
Pubmed	The C-type lectin-like domain superfamily.	CLEC18A CLEC18B CLEC18C	2.31e-08	3	100	3	16336259
Pubmed	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.	CLEC18A CLEC18B CLEC18C	2.31e-08	3	100	3	33603190
Pubmed	Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.	FUT3 FUT4 FUT5 FUT6	8.57e-08	15	100	4	11698403
Pubmed	The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.	CLEC18A CLEC18B CLEC18C	9.21e-08	4	100	3	16709836
Pubmed	Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cells.	FUT3 FUT5 FUT6	9.21e-08	4	100	3	19349624
Pubmed	Regulation of SERCA pumps expression in diabetes.	ATP2A2 ATP2A3	8.18e-06	2	100	2	25270119
Pubmed	The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor.	SORT1 SMPD1	8.18e-06	2	100	2	16787399
Pubmed	Down-regulation of FUT3 and FUT5 by shRNA alters Lewis antigens expression and reduces the adhesion capacities of gastric cancer cells.	FUT3 FUT5	8.18e-06	2	100	2	21978830
Pubmed	Correlation of FUT3 and FUT6 Gene Polymorphisms With Helicobacter pylori Infection.	FUT3 FUT6	8.18e-06	2	100	2	39108208
Pubmed	The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.	FUT4 FUT6	8.18e-06	2	100	2	20965272
Pubmed	Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI Is defined by amino acids near the N terminus of the catalytic domain.	FUT5 FUT6	8.18e-06	2	100	2	17604274
Pubmed	Alterations in genes encoding sarcoplasmic-endoplasmic reticulum Ca(2+) pumps in association with head and neck squamous cell carcinoma.	ATP2A2 ATP2A3	8.18e-06	2	100	2	18295663
Pubmed	Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1.	ATP2A2 ATP2A3	8.18e-06	2	100	2	19650915
Pubmed	Acceptor specificity of different length constructs of human recombinant alpha 1,3/4-fucosyltransferases. Replacement of the stem region and the transmembrane domain of fucosyltransferase V by protein A results in an enzyme with GDP-fucose hydrolyzing activity.	FUT3 FUT5	8.18e-06	2	100	2	7721776
Pubmed	Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3.	ATP2A2 ATP2A3	8.18e-06	2	100	2	21885870
Pubmed	Multiple and diverse coexpression, location, and regulation of additional SERCA2 and SERCA3 isoforms in nonfailing and failing human heart.	ATP2A2 ATP2A3	8.18e-06	2	100	2	19962989
Pubmed	Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.	FUT5 FUT6	8.18e-06	2	100	2	1339443
Pubmed	FUT family mediates the multidrug resistance of human hepatocellular carcinoma via the PI3K/Akt signaling pathway.	FUT4 FUT6	2.45e-05	3	100	2	24232099
Pubmed	Modulation of endoplasmic reticulum calcium pump by Bcl-2.	ATP2A2 ATP2A3	2.45e-05	3	100	2	9788433
Pubmed	Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis.	ATP2A2 ATP2A3	2.45e-05	3	100	2	16973504
Pubmed	Alteration of RANKL-induced osteoclastogenesis in primary cultured osteoclasts from SERCA2+/- mice.	ATP2A2 ATP2A3	2.45e-05	3	100	2	19419309
Pubmed	SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activity.	SELENON ATP2A2	2.45e-05	3	100	2	25452428
Pubmed	Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.	ATP2A2 ATP2A3	2.45e-05	3	100	2	15161756
Pubmed	The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors.	ATP2A2 ATP2A3	2.45e-05	3	100	2	16410239
Pubmed	Difucosylated oligosaccharide Lewis Y is contained within integrin αvβ3 on RL95-2 cells and required for endometrial receptivity.	FUT3 FUT4	2.45e-05	3	100	2	20605574
Pubmed	Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases.	ABL2 CAT	2.45e-05	3	100	2	12950161
Pubmed	Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab.	FUT3 FUT6	2.45e-05	3	100	2	20179215
Pubmed	Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.	ABL2 CAT	2.45e-05	3	100	2	12777400
Pubmed	SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.	SAV1 SLMAP	4.89e-05	4	100	2	29063833
Pubmed	Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.	MTHFR SLC29A1	4.89e-05	4	100	2	34331561
Pubmed	miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.	FUT5 FUT6	4.89e-05	4	100	2	28771224
Pubmed	The nongastric H+-K+-ATPases: molecular and functional properties.	ATP2A2 ATP2A3	4.89e-05	4	100	2	10362770
Pubmed	Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension.	SORT1 SMPD1	4.89e-05	4	100	2	35104805
Pubmed	PNPT1, MYO15A, PTPRQ, and SLC12A2-associated genetic and phenotypic heterogeneity among hearing impaired assortative mating families in Southern India.	PTPRQ MYO15A	4.89e-05	4	100	2	34374074
Pubmed	Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.	ATP2A2 ATP2A3	4.89e-05	4	100	2	25110346
Pubmed	Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19.	FUT3 FUT6	4.89e-05	4	100	2	7656588
Pubmed	SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets.	ATP2A2 ATP2A3	4.89e-05	4	100	2	18068335
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP8B2 ATP2A2 ATP2A3	7.98e-05	29	100	3	15071553
Pubmed	Catalase expression in MCF-7 breast cancer cells is mainly controlled by PI3K/Akt/mTor signaling pathway.	CAT PIK3CA	8.14e-05	5	100	2	24630930
Pubmed	A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers.	SEMA4B RASAL1	8.14e-05	5	100	2	35857828
Pubmed	A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.	ABL2 HGH1 SLC34A2 SORT1 MYO15A ATP2A2 TEDC1	8.87e-05	363	100	7	25036637
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	CLEC18A CLEC18B CLEC18C	1.67e-04	37	100	3	22432025
Pubmed	Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.	ATP2A2 ATP2A3	1.70e-04	7	100	2	24786561
Pubmed	Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.	FUT3 FUT6	1.70e-04	7	100	2	21203500
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH8 DNAH9	1.70e-04	7	100	2	31178125
Pubmed	The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.	SAV1 SLMAP	1.70e-04	7	100	2	23386615
Pubmed	Gene knockout studies of Ca2+-transporting ATPases.	ATP2A2 ATP2A3	2.27e-04	8	100	2	10951186
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	ATP2A2 ATP2A3	2.27e-04	8	100	2	19033399
Pubmed	Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development.	IZUMO1R MTHFR	2.27e-04	8	100	2	22365888
Pubmed	Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides.	ATP2A2 ATP2A3	2.27e-04	8	100	2	27923914
Pubmed	A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.	ATP2A2 ATP2A3	2.91e-04	9	100	2	25640239
Pubmed	Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection.	ABL2 PEPD TEDC1	3.20e-04	46	100	3	18330356
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	FUT4 DNAH8 DNAH9	3.41e-04	47	100	3	8812413
Pubmed	Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease.	CAT MESP1	4.43e-04	11	100	2	36693621
Pubmed	CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.	EPS8L2 MYO15A	5.30e-04	12	100	2	28663585
Pubmed	Identification and Herc5-mediated ISGylation of novel target proteins.	RGS3 FUT4	5.30e-04	12	100	2	16884686
Pubmed	Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.	FUT3 FUT6	6.25e-04	13	100	2	24941225
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SEMA4B SLC39A1 C1RL SELENON GGCX SORT1 SMPD1 ATP2A2 ATP2A3 SLC29A1 RUSF1	6.81e-04	1201	100	11	35696571
Pubmed	Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice.	SLC27A5 GOT2	7.28e-04	14	100	2	17463056
Pubmed	[Association of genetic factors with clinical peculiarities of hypertensive disease in patients with burdened familial anamnesis].	CAT MTHFR	7.28e-04	14	100	2	19254215
Pubmed	Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.	CAT MTHFR	7.28e-04	14	100	2	20078877
Pubmed	Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouse.	MESP1 FUT4	9.57e-04	16	100	2	27435625
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	MESP1 ATP2A2	1.08e-03	17	100	2	27725084
Pubmed	Genetic Hearing Loss Overview	PTPRQ SLC17A8 MYO15A	1.10e-03	70	100	3	20301607
Pubmed	Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.	PRKD3 PIK3CA	1.66e-03	21	100	2	9446795
Pubmed	HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.	PRKD3 PIK3CA	1.82e-03	22	100	2	11154208
Pubmed	The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.	ATP2A2 ATP2A3	1.82e-03	22	100	2	28890335
Pubmed	FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.	HGH1 SMPD1	1.99e-03	23	100	2	26124079
Pubmed	Identification of type 2 diabetes-associated combination of SNPs using support vector machine.	CAT PIK3CA MTHFR	2.33e-03	91	100	3	20416077
GeneFamily	Fucosyltransferases\|Blood group antigens	FUT3 FUT4 FUT5 FUT6	6.21e-08	13	57	4	434
GeneFamily	ATPases Ca2+ transporting	ATP2A2 ATP2A3	3.47e-04	9	57	2	1209
GeneFamily	C-type lectin domain family	CLEC18A CLEC18B CLEC18C	4.37e-04	47	57	3	494
GeneFamily	Dyneins, axonemal	DNAH8 DNAH9	1.29e-03	17	57	2	536
GeneFamily	Solute carriers	SLC39A1 SLC34A2 SLC26A1 SLC17A8 SLC29A1 SLC27A5	1.48e-03	395	57	6	752
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRH PTPRQ	1.97e-03	21	57	2	813
GeneFamily	Acyl-CoA synthetase family	ACSM1 SLC27A5	3.02e-03	26	57	2	40
GeneFamily	Actins\|Deafness associated genes	PTPRQ SLC17A8 MYO15A	5.44e-03	113	57	3	1152
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	FUT3 SLC29A1	6.06e-03	37	57	2	454
Coexpression	WAGNER_APO2_SENSITIVITY	FUT3 FUT4 FUT5 FUT6	2.69e-06	26	99	4	M13240
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8L2 C1RL SLC26A1 SLC17A8 MMD2 SLC27A5	3.72e-06	182	101	6	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8L2 C1RL SLC26A1 SLC17A8 MMD2 SLC27A5	3.72e-06	182	101	6	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8L2 C1RL SLC26A1 SLC17A8 MMD2 SLC27A5	3.72e-06	182	101	6	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Hpcal-Krt12_(Entorhinal_cortex)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	LRRC72 MESP1 STPG3 MYO15A	1.37e-05	64	101	4	2c214aa905083eb8bd8e66d33643987280030eb8
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Hpcal-Krt12_(Entorhinal_cortex)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	LRRC72 MESP1 STPG3 MYO15A	1.37e-05	64	101	4	813e9c3c10ebcee3638db843e19818bb37529895
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	MESP1 PTPRH FUT3 FUT6 ATP2A3	2.00e-05	145	101	5	e932361734839c14ffa0c1e028dcef9c833f884f
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	MESP1 PTPRH FUT3 FUT6 ATP2A3	2.07e-05	146	101	5	a4f2e3ea79e7154873c01739672ec6454547e6a6
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CUL7 CHD5 SLC17A8 MIEF1 TEDC1	3.51e-05	163	101	5	953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPN3 ACSM1 CAT PNPLA5 GOT2	3.72e-05	165	101	5	dba630e205eb3725195f8861e4af5b745ccfdc74
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPN3 ACSM1 CAT PNPLA5 GOT2	3.72e-05	165	101	5	a508d66031c1a46b062afbee3cde1cbd0c163a03
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPN3 ACSM1 CAT PNPLA5 GOT2	3.72e-05	165	101	5	b03c8c3110f32257e78838885b313a922af73c98
Drug	AC1MPID6	FUT3 FUT4 FUT5 FUT6	4.81e-09	6	98	4	CID003411618
Drug	AC1MQWF5	FUT3 FUT4 FUT5 FUT6	6.64e-08	10	98	4	CID003458642
Drug	AC1MPID3	FUT3 FUT4 FUT5 FUT6	1.19e-06	19	98	4	CID003411617
Drug	(2S,3R,4S,5S,6R)-2-benzyl-6-(hydroxymethyl)oxane-3,4,5-triol	FUT3 FUT4 FUT5 FUT6	2.68e-06	23	98	4	CID010332525
Drug	selenate	CAT SLC26A1 FUT3 FUT5 FUT6	6.03e-06	60	98	5	CID000001089
Drug	2'-fucosyllactose	FUT3 FUT4 FUT5 FUT6	8.12e-06	30	98	4	CID000170484
Drug	lacto-N-tetraose	FUT3 FUT4 FUT5 FUT6	1.06e-05	32	98	4	CID000440993
Drug	nifedipine	SLC39A1 CAT PRKD3 CACNA2D4 SMPD1 CYP4F3 FUT3 ATP2A2 ATP2A3 GOT2	1.22e-05	415	98	10	CID000004485
Drug	NSC239129	C1RL ATP2A2 ATP2A3	3.39e-05	15	98	3	CID000084597
Drug	2a-e	CAT FUT3 FUT5 FUT6	3.50e-05	43	98	4	CID000006942
Disease	alpha-(1;3)-fucosyltransferase 5 measurement	FUT3 FUT5 FUT6	1.25e-07	4	94	3	EFO_0021979
Disease	candidiasis (implicated_via_orthology)	PRKD3 FUT3 FUT4 FUT5 FUT6	2.90e-07	44	94	5	DOID:1508 (implicated_via_orthology)
Disease	galactoside 3(4)-L-fucosyltransferase measurement	FUT3 FUT5 FUT6	1.09e-06	7	94	3	EFO_0021853
Disease	alpha-(1,3)-fucosyltransferase 5 measurement	FUT3 FUT5 FUT6	1.09e-06	7	94	3	EFO_0020136
Disease	Urolithiasis	SLC26A1 GGCX	3.01e-05	3	94	2	C0451641
Disease	Brody myopathy (implicated_via_orthology)	ATP2A2 ATP2A3	3.01e-05	3	94	2	DOID:0050692 (implicated_via_orthology)
Disease	rectal benign neoplasm (is_implicated_in)	PIK3CA MTHFR	3.01e-05	3	94	2	DOID:1984 (is_implicated_in)
Disease	serum carcinoembryonic antigen measurement	FUT3 FUT5 FUT6	3.43e-05	20	94	3	EFO_0005760
Disease	cancer antigen 19.9 measurement	FUT3 FUT6	6.00e-05	4	94	2	EFO_0010584
Disease	polyp of gallbladder	FUT3 FUT6	6.00e-05	4	94	2	MONDO_0021416
Disease	desmoglein-2 measurement	FUT3 FUT6	9.98e-05	5	94	2	EFO_0020322
Disease	level of V-set and immunoglobulin domain-containing protein 2 in blood serum	FUT3 FUT6	9.98e-05	5	94	2	OBA_2044774
Disease	lactoperoxidase measurement	FUT3 FUT6	1.49e-04	6	94	2	EFO_0020525
Disease	neurodegenerative disease (biomarker_via_orthology)	CAT GOT2	1.49e-04	6	94	2	DOID:1289 (biomarker_via_orthology)
Disease	lithostathine-1-alpha measurement	FUT3 FUT6	2.09e-04	7	94	2	EFO_0801083
Disease	angle-closure glaucoma (is_implicated_in)	CAT MTHFR	2.09e-04	7	94	2	DOID:13550 (is_implicated_in)
Disease	folic acid measurement	MTHFR TUBA4B MYO15A	4.30e-04	46	94	3	EFO_0005111
Disease	Pulmonary Thromboembolisms	CAT MTHFR	6.49e-04	12	94	2	C0524702
Disease	Pulmonary Embolism	CAT MTHFR	6.49e-04	12	94	2	C0034065
Disease	Fetal Alcohol Spectrum Disorders	CAT PIK3CA	7.65e-04	13	94	2	C2985290
Disease	urate measurement, bone density	BAZ2B PPFIA2 SELENON PSMG3-AS1 SLC17A8 DNAH8 DNAH9 RASAL1	8.20e-04	619	94	8	EFO_0003923, EFO_0004531
Disease	cancer biomarker measurement	FUT3 FUT6	1.03e-03	15	94	2	EFO_0005127
Disease	galectin-3 measurement	FUT3 FUT6	1.17e-03	16	94	2	EFO_0008137
Disease	Fetal Alcohol Syndrome	CAT PIK3CA	1.32e-03	17	94	2	C0015923
Disease	glucose homeostasis measurement, acute insulin response measurement	ATP2A2 ATP2A3	1.49e-03	18	94	2	EFO_0006831, EFO_0006896
Disease	essential hypertension (is_implicated_in)	CAT ATP2A2	1.49e-03	18	94	2	DOID:10825 (is_implicated_in)
Disease	Nonsyndromic genetic hearing loss	PTPRQ SLC17A8 MYO15A	1.86e-03	76	94	3	cv:C5680182
Disease	hypothyroidism (biomarker_via_orthology)	CAT MTHFR ATP2A2	2.15e-03	80	94	3	DOID:1459 (biomarker_via_orthology)
Disease	N-glycan measurement	FUT3 FUT6	2.23e-03	22	94	2	EFO_0004999
Disease	e-selectin measurement	FUT3 FUT6	2.23e-03	22	94	2	EFO_0004575
Disease	Nonsyndromic Deafness	EPS8L2 SLC17A8 MYO15A	2.23e-03	81	94	3	C3711374
Disease	Kidney Diseases	MTHFR SMPD1 RASAL1	2.82e-03	88	94	3	C0022658

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRARWLMPVIPALWE	C8orf44	36	Q96CB5
FSDWGMEWAQPRLPK	NKAPP1	56	Q8N9T2
LKDPDMVWDFWSLRP	CAT	176	P04040
RILHWRWTEPPAPFM	CHD5	471	Q8TDI0
ELMRACWKWSPADRP	ABL2	516	P42684
WFPQPHVPWRDMEGK	BTNL2	386	Q9UIR0
AMAKAWEPWLPAEAL	SMPD1	346	P17405
SPKPIPEEMQFGWWR	BAZ2B	1706	Q9UIF8
WDLTPMLSSSEPWGR	EPN3	361	Q9H201
MRPTWKALSHPAWPE	ARL9	1	Q6T311
TLVWRPGGELWIEPM	C16orf54	71	Q6UWD8
SLLRMPPWMNPWLLV	ATP2A3	921	Q93084
EMPEKWARAQAPPSW	ATP8B2	6	P98198
GAPSPLRVELWDWDM	RASAL1	191	O95294
KPGVWWPDMHRLADR	PEPD	321	P12955
LSLPIFPGWMEWLSP	RGS3	96	P49796
FPGWMEWLSPDIALP	RGS3	101	P49796
PRAPWMEREGPKYWD	HLA-H	71	P01893
VPSRMVPRPKDDWDW	DZIP1L	636	Q8IYY4
LGMWTEDPRRPLPWA	MTHFR	336	P42898
PWLNLRELGPWASHM	MMD2	121	Q8IY49
WTLPGMRATWQPAPF	PSMG3-AS1	6	Q96PY0
PLLLELWTVMPTWAG	IZUMO1R	6	A6ND01
SWEEVGPPSWRNKMH	MYO15A	1191	Q9UKN7
RVENWPLMQSPWPTL	ELOVL4	36	Q9GZR5
ATSSPRPPGQRWVWM	FUT4	281	P22083
WELDNVLMPSPRIWP	KCNJ5-AS1	26	Q8TAV5
NDILGMWIPEVLDWP	HERC1	2951	Q15751
PLLWPWKLDNRGRRM	DDX60L	1606	Q5H9U9
GRALPAWRWRPMTEL	CUL7	456	Q14999
PPKPYRWILDMTWLN	DNAH8	3796	Q96JB1
PSKRIPSWSGRPIWM	PRKD3	246	O94806
SGKRSWEEPNWMGSP	MIEF1	66	Q9NQG6
WEEPNWMGSPRLLNR	MIEF1	71	Q9NQG6
WPRWLADKMLPLLGA	PLA2G4F	6	Q68DD2
EDWMSALCPRLWDVP	PLCXD1	21	Q9NUJ7
GESWMRPRSEWPREP	EPS8L2	396	Q9H6S3
KRPLWLNWENPDIMS	PIK3CA	776	P42336
GMLWLLALAWPPQAR	LRIT1	6	Q9P2V4
KMRPASWGAPISWEQ	MFSD14A	216	Q96MC6
PLPGTVGDFWRMVWE	PTPRQ	2111	Q9UMZ3
IDMPPTEDRSWWRGK	ARHGAP33	216	O14559
EWCLPDMELWPRELT	BTBD18	541	B2RXH4
LLRMPPWENIWLVGS	ATP2A2	921	P16615
WVMGRPFGSEQRPKW	CARD6	751	Q9BX69
MPVRTLFPESWLWRK	C3P1	1	Q6ZMU1
SSRWIPLQPMPVAWA	CACNA2D4	31	Q7Z3S7
SPPPESSWRRTMAWG	CRTC2	136	Q53ET0
MPGPRVWGKYLWRSP	C1RL	1	Q9NZP8
PKRSWGTWEEAMCPL	C16orf90	156	A8MZG2
MDPLGPAKPQWSWRC	FUT6	1	P51993
WVSRWMEGAPPRMPS	FRMD6-AS1	346	P0C7T7
LQDWLRSPGMDSKPW	FAM47A	6	Q5JRC9
WVWTRMNPSGVKPTP	KLHDC4	281	Q8TBB5
LSSLGLWPMAASPWL	CYP4F3	6	Q08477
RWPLMVDPQLQGIKW	DNAH9	3461	Q9NYC9
PGWPAFMRINPLLDW	FLAD1	506	Q8NFF5
LPRMPWAMIWDFTEP	IRF2BP2	21	Q7Z5L9
PEDLRLVLMPWGPWH	MENT	196	Q9BUN1
MSWDPNPVPRTLRCW	LRRC72	1	A6NJI9
PTVVAWLELWLGMPA	PPFIA2	901	O75334
PARLMGRALDPQWPW	HGH1	106	Q9BTY7
MDPLGAAKPQWPWRR	FUT3	1	P21217
MDPLGPAKPQWLWRR	FUT5	1	Q11128
ANRMEPLWTGFWPAP	RUSF1	311	Q96GQ5
MERPWGAADGLSRWP	SORT1	1	Q99523
RSVWPPMVWLDLQDR	FER1L5	1166	A0AVI2
RWLLWPMLFPVAPRD	MOV10	466	Q9HCE1
LGSPWPENFWEDLIM	MYCT1	56	Q8N699
LPDVPADLWWMQGLL	PNPLA5	366	Q7Z6Z6
MGLRSWLAAPWGALP	SEMA4B	6	Q9NPR2
LWPELGRLEHPMFWP	SETD6	146	Q8TBK2
WMKQDPRRWGNPARA	SHISAL1	141	Q3SXP7
IKEGWIPMPVRRSWL	SPATA31E1	776	Q6ZUB1
ESWMLSAAWGPTRRP	MESP1	11	Q9BRJ9
LETWMPLSPLEWLPE	MESP1	251	Q9BRJ9
FMWPGKDSRWLPSLV	SLC29A1	351	Q99808
WWQRLPMPALSLPTR	TUBA4B	226	Q9H853
SWWTHVEMGPPDPIL	GOT2	31	P00505
GDHLALMLPRVPEWW	ACSM1	111	Q08AH1
WVQPPAADMRRLDWS	CLEC18A	61	A5D8T8
WVQPPAADMRRLDWS	CLEC18B	61	Q6UXF7
WVQPPAADMRRLDWS	CLEC18C	61	Q8NCF0
NFLPLWMRSLKPWDA	SLC34A2	591	O95436
LPPGWSVDWTMRGRK	SAV1	201	Q9H4B6
AGAPSPWPWEARLMH	PRSS53	306	Q2L4Q9
MGTEWTLWVFPPLKR	TRIML2	346	Q8N7C3
MAAPWRRWPTGLLAV	TMEM223	1	A0PJW6
WVQPLLMDLSPWRAK	GGCX	501	P38435
RVPTWGALPAWAMEL	ZFR2	801	Q9UPR6
PLSDTAPPRDSWMFW	NUFIP1	26	Q9UHK0
APPRDSWMFWAMLPP	NUFIP1	31	Q9UHK0
KVWDLPRLWRMSPAD	SLC26A1	456	Q9H2B4
PRLWRMSPADALVWA	SLC26A1	461	Q9H2B4
LGLAMLARPWLGPWV	SLC27A5	46	Q9Y2P5
MGPWGEPELLVWRPE	SLC39A1	1	Q9NY26
PMHPSGWPTLLWAVD	STPG3	356	Q8N7X2
LLREKGNNKPWPWMP	SLMAP	791	Q14BN4
MRPWALAVTRWPPSA	RNF44	1	Q7L0R7
TPGMGPRTFWNDLWL	TEDC1	251	Q86SX3
ELGEPWWIIPSELSM	SELENON	216	Q9NZV5
MRVPPAGTWALRPIW	ZNF516-DT	1	Q6ZTR6
ELMPPTLKWQERWPV	SPTY2D1OS	21	A0A0U1RRN3
VMLWWKAPGDPHSQL	PTPRH	581	Q9HD43
GPQGSWRFLEWKSMP	USP6	441	P35125
WRFLEWKSMPRLPTD	USP6	446	P35125
MWSKWAPPLERSRLA	SLC17A8	206	Q8NDX2
LLWVWLQGTDFMPDP	XKR8	241	Q9H6D3