Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoabnormal somatosensory cortex morphology

KCNQ2 LEF1 ARHGAP33

4.20e-0533293MP:0000859
MousePhenoabnormal parietal lobe morphology

KCNQ2 LEF1 ARHGAP33

5.95e-0537293MP:0000794
DomainRhoGAP

ARHGAP27 MYO9A ARHGAP33

2.71e-0462383SM00324
DomainRhoGAP

ARHGAP27 MYO9A ARHGAP33

2.84e-0463383PF00620
DomainRHOGAP

ARHGAP27 MYO9A ARHGAP33

2.97e-0464383PS50238
DomainRhoGAP_dom

ARHGAP27 MYO9A ARHGAP33

2.97e-0464383IPR000198
Domain-

ARHGAP27 MYO9A ARHGAP33

2.97e-04643831.10.555.10
DomainRho_GTPase_activation_prot

ARHGAP27 MYO9A ARHGAP33

7.57e-0488383IPR008936
DomainMYOSIN_MOTOR

MYO9A MYO16

2.71e-0338382PS51456
DomainMyosin_head

MYO9A MYO16

2.71e-0338382PF00063
DomainMyosin_head_motor_dom

MYO9A MYO16

2.71e-0338382IPR001609
DomainMYSc

MYO9A MYO16

2.71e-0338382SM00242
DomainHEAT

DNAAF5 MMS19

4.29e-0348382PF02985
DomainHEAT

DNAAF5 MMS19

6.20e-0358382IPR000357
DomainHEAT_REPEAT

DNAAF5 MMS19

8.92e-0370382PS50077
DomainAnk_2

CLIP3 KANK2 MYO16

9.44e-03215383PF12796
Domain-

DNAAF5 MMS19 USP9X

1.03e-022223831.25.10.10
DomainAnk

CLIP3 KANK2 MYO16

1.11e-02228383PF00023
DomainIQ

MYO9A MYO16

1.18e-0281382SM00015
Domain-

CLIP3 KANK2 MYO16

1.39e-022483831.25.40.20
DomainANK

CLIP3 KANK2 MYO16

1.43e-02251383SM00248
DomainIQ_motif_EF-hand-BS

MYO9A MYO16

1.44e-0290382IPR000048
DomainANK_REPEAT

CLIP3 KANK2 MYO16

1.46e-02253383PS50088
DomainAnkyrin_rpt-contain_dom

CLIP3 KANK2 MYO16

1.48e-02254383IPR020683
DomainANK_REP_REGION

CLIP3 KANK2 MYO16

1.48e-02254383PS50297
Pubmed

A limited panel of INSM1 and LEF1 immunostains accurately distinguishes between pancreatic neuroendocrine tumor and solid pseudopapillary neoplasm.

LEF1 INSM1

1.23e-06239234048981
Pubmed

TBX20 inhibits colorectal cancer tumorigenesis by impairing NHEJ-mediated DNA repair.

TBX20 PDZRN3

7.34e-06439235348274
Pubmed

Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships.

ARHGAP27 ARHGAP33

1.22e-05539212297274
Pubmed

Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal.

TBX20 LEF1

1.22e-05539219952280
Pubmed

PRC2 Is Dispensable in Vivo for β-Catenin-Mediated Repression of Chondrogenesis in the Mouse Embryonic Cranial Mesenchyme.

LEF1 SP7

3.42e-05839229223978
Pubmed

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.

SCAF1 GPATCH8 TOP1

3.47e-055639326919559
Pubmed

Tagging genes with cassette-exchange sites.

MMS19 GPATCH8 TOP1 USP9X FBXO15

3.54e-0533539515741177
Pubmed

Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.

SIN3B MMS19 TNRC18

5.18e-056439322865885
Pubmed

Prickle1 regulates differentiation of frontal bone osteoblasts.

LEF1 SP7

6.70e-051139230575813
Pubmed

Twist1 mediates repression of chondrogenesis by β-catenin to promote cranial bone progenitor specification.

LEF1 SP7

6.70e-051139223095887
Pubmed

GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis.

LEF1 SP7

8.03e-051239236449606
Pubmed

Deficiency of Fam20b-Catalyzed Glycosaminoglycan Chain Synthesis in Neural Crest Leads to Cleft Palate.

LEF1 SP7

8.03e-051239237298583
Pubmed

SOX9 modulates the expression of key transcription factors required for heart valve development.

TBX20 LEF1

1.11e-041439226525672
Pubmed

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

LEF1 SP7

1.27e-041539215866165
Pubmed

The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification.

LEF1 SP7

1.46e-041639221571217
Pubmed

The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation.

LEF1 SP7

1.46e-041639219557172
Pubmed

Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling.

LEF1 PDZRN3

1.65e-041739215511637
Pubmed

Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice.

LEF1 SP7

2.07e-041939232290615
Pubmed

Twist1 contributes to cranial bone initiation and dermal condensation by maintaining Wnt signaling responsiveness.

LEF1 SP7

2.07e-041939226677825
Pubmed

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis.

LEF1 SP7

2.07e-041939215866164
Pubmed

Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation.

TBX20 INSM1

2.07e-041939221068058
Pubmed

Segmental variations in trabecular bone density and microstructure of the spine in senescence-accelerated mouse (SAMP6): a murine model for senile osteoporosis.

LEF1 SP7

2.07e-041939222342532
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SCAF1 MMS19 KANK2 ARRDC4 TOP1 PDZRN3 ARHGAP33

2.15e-04111639731753913
Pubmed

Sequential roles of Hedgehog and Wnt signaling in osteoblast development.

LEF1 SP7

2.30e-042039215576404
Pubmed

Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.

TBX20 INSM1

2.54e-042139219542360
Pubmed

Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling.

LEF1 SP7

2.54e-042139234172578
Pubmed

Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.

SIN3B TNRC18 GPATCH8

2.59e-0411039326841866
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

SIN3B MMS19 TNRC18 USP9X

2.78e-0428239423667531
Pubmed

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning.

TBX20 LEF1

3.05e-042339216314491
Pubmed

The functional interactome landscape of the human histone deacetylase family.

SIN3B TNRC18 TOP1 USP9X

3.05e-0428939423752268
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

MMS19 TBKBP1 CMYA5 MYO9A TOP1 USP9X

3.30e-0484439625963833
Pubmed

Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin.

LEF1 SP7

3.33e-042439232186512
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

MMS19 GPATCH8 ARRDC4 USP9X

4.13e-0431339438270169
Pubmed

Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis.

TBX20 LEF1

4.23e-042739223824573
Pubmed

Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.

ERMP1 MYO16

4.88e-042939212652657
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

TNRC18 TBKBP1 USP9X TMEM151B

5.15e-0433239437433992
Pubmed

Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.

MYO9A MYO16 ARHGAP33

5.58e-0414339332560809
Pubmed

Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.

TBX20 LEF1

5.58e-043139222711842
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

MMS19 KANK2 USP9X

7.19e-0415639322952844
Pubmed

The developing mouse coronal suture at single-cell resolution.

LEF1 SP7

7.96e-043739234376651
Pubmed

USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.

PROB1 CMYA5

7.96e-043739232133736
Pubmed

Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis.

LEF1 SP7

8.40e-043839216818445
Pubmed

Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors.

LEF1 SP7

8.84e-043939224586192
InteractionNARF interactions

MMS19 LEF1 MPPED1

1.16e-0523393int:NARF
InteractionTMOD4 interactions

SHD KANK2 MYO9A

2.36e-0529393int:TMOD4
InteractionARID4B interactions

SIN3B TNRC18 TOP1 USP9X SP7

3.91e-05199395int:ARID4B
Cytoband17q21.31

ARHGAP27 GPATCH8 FAM171A2

5.57e-058241317q21.31
CytobandEnsembl 112 genes in cytogenetic band chr17q21

TBKBP1 ARHGAP27 GPATCH8 FAM171A2

8.33e-04473414chr17q21
Cytoband19q13.12

CLIP3 ARHGAP33

1.91e-037241219q13.12
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP27 ARHGAP33

2.52e-0350272721
GeneFamilyAnkyrin repeat domain containing

CLIP3 KANK2 MYO16

5.46e-03242273403
ToppCellwk_08-11-Epithelial-PNS-MFNG+_DBH+_neuron|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SHD KCNQ2 TBX20 TMEM151B INSM1

8.01e-07188415d3d7d21d4fa39ac4106a164652673de1bef8662d
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 PDZRN3 TMEM151B INSM1

8.66e-07191415c7b95a5f9185d533c08754ce2e4ce91533eb612e
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 PDZRN3 TMEM151B INSM1

8.89e-0719241556f2388c9c4e19883ae5cff332c77f596ff744a8
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD ZFHX2 KCNQ2 INSM1

1.96e-05174414271c51d220842402975d97c86c9acfdbdf62a32c
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 PDZRN3 INSM1

2.00e-051754142ce8bcf9926862e723219b4246388428d0c3fdee
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 PDZRN3 INSM1

2.09e-05177414d1dd778d1a52305b1ea3954f81fd5364b3d57bbe
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 FBXO15 INSM1

2.54e-051864144fe8e0bf74c7dbf73634cafdacad89020d2634d0
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SHD KCNQ2 FAM171A2 INSM1

2.54e-0518641410565fce7e1b4ec88bc8e1ed6410a83800be5014
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD ZFHX2 KCNQ2 INSM1

2.65e-05188414459e3fd4335a6f25f982d011b38702f4fcfed1cd
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD ZFHX2 KCNQ2 INSM1

2.65e-051884149fd262bbf6cdebfd945e39428a6059726fb55b3a
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIP3 KANK2 PDZRN3 MPPED1

2.82e-05191414b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD ZFHX2 TMEM151B INSM1

2.88e-05192414d8f5df2c2a50e567f24ebecc8033ac97ba89d9c5
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD ZFHX2 TMEM151B INSM1

2.94e-051934149661ea0ee7273928c7de2a9f49e853595fa77699
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD ZFHX2 SMIM28 TMEM151B

3.06e-05195414b25c534fc6320d4da6437ef1b27e32a5d5256f3e
ToppCellwk_08-11-Epithelial-PNS-TM4SF4+_PENK+_neuron|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SHD ZFHX2 TBX20 INSM1

3.12e-05196414afa3a2f5f3a51d1830c6f95f97a4b3e13ed42512
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal-INs|6_mon / Sample Type, Dataset, Time_group, and Cell type.

LRTM1 KCNQ2 PDZRN3 INSM1

3.12e-05196414556e18eae05bf19259fe02848bcc9120aa2a9d29
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD ZFHX2 SMIM28 TMEM151B

3.18e-051974148951787ed1f7ac1772a6ef0ba2dd44c51fd3c47b
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 PDZRN3 INSM1

3.24e-05198414c506334d81af672ef9ddc8c4fd2a790bdb58e63e
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD SMIM28 TMEM151B INSM1

3.24e-0519841450504a3871f76d6a5b439a56450d7770f4501eb0
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 GAREM1 INSM1

3.31e-05199414ce699726ac4825c65bf934cb9a76202ad7340596
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 SMIM28 INSM1

3.31e-05199414f2410509007d35e948a88f127f613d0119e6a4c4
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 GAREM1 INSM1

3.31e-05199414f1d5808ccb1d5d4e2d34f864e705e2484000e88f
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX2 SIN3B LEF1

1.53e-04113413357bc20edc5bc14eab8262d52260ed1686e9dc54
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX2 SIN3B LEF1

1.53e-0411341391e73e3b93be242fef0f14eddd8085a1f1c730ef
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KCNQ2 PDZRN3 MYO16

2.07e-04125413b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-5|TCGA-Adrenal / Sample_Type by Project: Shred V9

SHD KCNQ2 INSM1

2.53e-04134413d4b175257c47916ed90cdb5c555c2b26530ce8d5
ToppCellTCGA-Adrenal|World / Sample_Type by Project: Shred V9

RXFP3 TBX20 INSM1

3.19e-04145413522ad2bc90b8ec326fcbc7b2250b09566efeeca2
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-2|TCGA-Lung / Sample_Type by Project: Shred V9

SMIM28 INSM1 SP7

3.33e-04147413457bc1175810f241ed8966b76ed4fc4ef3fb144c
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Hippocampus / BrainAtlas - Mouse McCarroll V32

RXFP3 MYO16 MGRN1

4.34e-04161413b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SHD TMEM151B INSM1

4.34e-04161413bd520c9a1927d5d5355b4421e6b90b58bfb76a42
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

4.50e-0416341399cf60dc87f7ce288553091bffcd85109a02bd8f
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

4.50e-04163413510c0af66e82c5a8cf8edd0547dae4018a87dbbf
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-1|TCGA-Ovary / Sample_Type by Project: Shred V9

FAM171A2 MPPED1 TMEM151B

4.66e-041654132ca1154a8692af311d99a4d3aa2f2ac3d23a4310
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LRTM1 ERMP1 GAREM1

4.74e-04166413f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCellfacs-Lung-nan-3m-Epithelial-type_I_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACOT6 PDZRN3 MYO16

4.74e-0416641311b0ae82b3068ef91715dbdd49fe8e9791b4a480
ToppCellfacs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACOT6 PDZRN3 MYO16

4.74e-04166413fcc1aec31ebd39432d4cb284dc8fadf34e3c566a
ToppCellfacs-SCAT-Fat-18m-Lymphocytic-T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX2 LEF1 ARHGAP33

5.00e-04169413700a3a36c379872585204caa6a6cc269b036ae22
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-5|TCGA-Bladder / Sample_Type by Project: Shred V9

SHD TMEM151B INSM1

5.00e-041694139c4e83fe8225d16173a103bf5a57b17d623be923
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LRTM1 KANK2 TMEM151B

5.17e-04171413a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP27 KANK2 MYO9A

5.26e-041724137fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

5.26e-04172413bc3ed05fdd94d5e1f19285aea867b1453292baec
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP27 KANK2 MYO9A

5.26e-041724132a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CLIP3 PDZRN3 GAREM1

5.72e-041774133d955ea938a1d2fb1b6d68d4997fd454bd632dfc
ToppCellwk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SHD TMEM151B SP7

5.72e-0417741315a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

5.72e-041774136f3b254e56e722cc23495b49e99a4abce0243cb3
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

5.81e-04178413a9ba4089413b1c55d667ce836b6972ca572ee2b8
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

5.81e-0417841313dfd28a80889c2dacdc65b94a41bb9762dc409d
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_2|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

SHD PDZRN3 INSM1

5.91e-04179413d95367d689732ab2653e8d70d8d8e5eb15ae6eef
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIP3 KANK2 PDZRN3

5.91e-0417941302c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX2 KCNQ2 SMIM28

5.91e-04179413b8ca29aebd25ebac441bebd769bbf98c536d3166
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 FAM171A2

6.00e-04180413c72f15763ba707189e29c85db533557f01c7fdb1
ToppCellfacs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAAF5 PDP1 GAREM1

6.00e-041804137368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

CMYA5 TBX20 PDZRN3

6.10e-04181413719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

6.10e-04181413f2ebeb4941510c4b6e50f2379c574d1778d6ced1
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

6.20e-04182413d6740bca2b974122b8451989365a94a81140afd1
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERMP1 FAM171A2 TMEM151B

6.20e-04182413fe4fb213dc0ca482b0f94097fe1b0a51fc2690e2
ToppCellIIH-Treg-proli_CD4|IIH / Condition, Cell_class and T cell subcluster

SCAF1 MMS19 TNRC18

6.20e-041824135c7d02da9ca2bca49db9832704b6894dfaa08a71
ToppCellwk_15-18-Epithelial-PNS-Early_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SHD KCNQ2 INSM1

6.30e-041834137e8366ec8117d36cec67f77dcb0e9a6032d87fcb
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

6.40e-041844137aa245b73e10fd73d292e822de6b72920aa12355
ToppCellCOVID-19-Heart-CM_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

CMYA5 TBX20 PDZRN3

6.40e-04184413e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

6.40e-041844137712f2e1fae5cdde2d4e355b860dc8536b28e4f6
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD TBX20 INSM1

6.50e-04185413ef996f4cdbc3971c6c0460d13df64b075ab22154
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

6.50e-041854130149981d3818a6250f32c08456c28e7037c39d91
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD TBX20 INSM1

6.50e-04185413d51342a3979bd728a80e04126059a3fd8a0dbe3b
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIP3 KANK2 PDZRN3

6.60e-041864136add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCellwk_15-18-Epithelial-PNS-MFNG+_DBH+_neuron|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TBX20 TMEM151B INSM1

6.60e-0418641372f7427d62d65e37bb0bf99229a1b75df081a128
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SHD PDZRN3 INSM1

6.60e-04186413a07694caf7fede06a47636725bcc7f09909cdf07
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

6.71e-04187413dfc2b95d70daf533bc0cc4ce78af9f65dd75a25b
ToppCell5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNQ2 LEF1 TMEM151B

6.71e-04187413442b7bf6bc17fc2d38bccd678be8994b0ead374f
ToppCell5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNQ2 LEF1 TMEM151B

6.71e-04187413c0a18ab7d88420e20e478ccdce6a2cb0a60a7824
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD SMIM28 TMEM151B

6.71e-04187413a748b3a59e398e0da019db3f16d38adb1960c29f
ToppCell5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNQ2 LEF1 TMEM151B

6.71e-04187413fda45c15806f34e45d44bb2e1d144591bc6eaa02
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERMP1 FAM171A2 MYO9A

6.71e-041874139225caf66e06ebe57e90d677122acb6498607f36
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIP3 KANK2 PDZRN3

6.81e-041884133177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

6.81e-0418841333afe31b1093d317dc38c324197c6e91bf6c39d3
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIP3 KANK2 PDZRN3

6.81e-04188413293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SHD FAM171A2 INSM1

6.92e-041894138e6b6025f5554672e26a5d19fe365acb4333789c
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

CMYA5 PDZRN3 GAREM1

6.92e-041894130a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SHD TBX20 INSM1

6.92e-04189413de06ef69f3f97b3f21dc269eb6965da9b2f6e3f8
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIP3 KANK2 PDZRN3

6.92e-0418941345e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellfacs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRTM1 CLIP3 PDZRN3

7.02e-04190413c7bd087f36321cec61b98657433b4d19d135791f
ToppCellfacs-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRTM1 CLIP3 PDZRN3

7.02e-04190413834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ERMP1 FAM171A2 MYO9A

7.02e-04190413a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCellwk_08-11-Epithelial-PNS-Schwann_precursor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SHD KCNQ2 INSM1

7.02e-041904134a777d8aa19cadd3b61b023772df142421a89113
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDZRN3 PDP1 MYO16

7.02e-041904131bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Immature_INs|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

SHD PDZRN3 INSM1

7.02e-04190413842760bfe0a52e67bad800efa7d99448a4a23ebb
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

7.02e-041904135a82709eeb68df4563bb42b97636d110126d2f97
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIP3 KANK2 PDZRN3

7.13e-041914137853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD SMIM28 PDZRN3

7.13e-0419141373b15ffa60d592c43aaa575f1b1479d49a66dfe8
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KANK2 PDZRN3 MYO16

7.13e-0419141314057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

7.13e-04191413a53616c84178eb6c29b48662358765b082df3f97
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

7.24e-041924133fc7a661ef39286abfd82ed8ab580011f01cb8fd
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIP3 KANK2 PDZRN3

7.24e-04192413992d08092edbc68c47b945deb8708379738c239a
ToppCelldroplet-Thymus-nan-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIN3B LEF1 TOP1

7.35e-0419341381871f4f2b63ca5f64a9ff12f6c909a34bf52216
ToppCellwk_15-18-Epithelial-PNS|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SHD TMEM151B INSM1

7.35e-04193413ca65f8f93058ad50d89e69e06c10deeb46dbfc87
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

7.35e-041934134f4f430d7e1b65e19ca829f55ca93edeb6c1c85d
ToppCelldroplet-Thymus-nan-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIN3B LEF1 TOP1

7.35e-0419341312380713db6582749183a19de65d4af9d6469a3f
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

7.35e-0419341366af80f4b51e1ce97b6fb7c630dc5f95bfa7e7d4
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERMP1 FAM171A2 MYO9A

7.35e-041934130f2167eef8203a5659c8c72e4e77646003d64797
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNQ2 INSM1

7.35e-04193413d5930f7bd9b299f792212d40a3272a37adf64a82
Diseaseprogranulin measurement

GPATCH8 FAM171A2

3.87e-0422392EFO_0004625
Diseasefree cholesterol measurement

TBKBP1 KANK2 TOP1

4.52e-04113393EFO_0008591
Diseaseresting heart rate

WIPF1 TBX20 GAREM1

1.01e-03149393EFO_0004351
Diseaseleft ventricular diastolic function measurement

GAREM1 SP7

2.33e-0354392EFO_0008204
Diseaseelectroencephalogram measurement

CMYA5 MYO16

4.33e-0374392EFO_0004357
Diseasecancer (implicated_via_orthology)

SIN3B KANK2 TOP1

5.32e-03268393DOID:162 (implicated_via_orthology)
Diseaselipid measurement, lipoprotein measurement

TBKBP1 TOP1

6.34e-0390392EFO_0004529, EFO_0004732
Diseasecholesteryl ester measurement, intermediate density lipoprotein measurement

TBKBP1 KANK2

6.89e-0394392EFO_0008595, EFO_0010351
Diseaselipid measurement, intermediate density lipoprotein measurement

TBKBP1 TOP1

7.18e-0396392EFO_0004529, EFO_0008595
Diseasephospholipid measurement, intermediate density lipoprotein measurement

TBKBP1 TOP1

7.62e-0399392EFO_0004639, EFO_0008595
Diseasehair color

ERMP1 RXFP3 LEF1

8.01e-03311393EFO_0003924
Diseaseobsolete_red blood cell distribution width

AK9 TBKBP1 ARHGAP27 KANK2 MYO16 SP7

8.02e-031347396EFO_0005192

Protein segments in the cluster

PeptideGeneStartEntry
PETGHCIDPPYFPPS

ACOT6

356

Q3I5F7
YLPAPEVSPRNPPHF

ERMP1

761

Q7Z2K6
RFQPPPLYSEVDPHP

ARRDC4

391

Q8NCT1
PPEHPPQAYGVPIVF

MSANTD5

146

A0A3B3IT52
PSPPVLDPYLLPEEH

PDZRN3

376

Q9UPQ7
RHPPAPDIPTFYPLS

LEF1

186

Q9UJU2
HELYQPCPLPAPDPV

LRTM1

226

Q9HBL6
PYRPCAHLAFPPEPA

MYO16

1586

Q9Y6X6
YFPIDFTPPPNDPHG

MMS19

221

Q96T76
RPVQFPYVTPAPHEP

MGRN1

66

O60291
PIAPDLEHFPSYAPP

GPATCH8

1271

Q9UKJ3
AKEPEPAPPYHSPED

KCNQ2

661

O43526
VPSPPPRNPYDLHFI

GAREM1

251

Q9H706
VDPVPHDAPKPPGYT

MPPED1

76

O15442
PPNYHTPPYLTAEPE

PDP1

386

Q9P0J1
LHEPPSPPPPFDHYL

FAM171A2

471

A8MVW0
LSYPPAPSCFPPDHL

ARHGAP33

1136

O14559
LPPHSPFLDDSPEYG

FBXO15

336

Q8NCQ5
YPESPLVSEKPFPPH

CMYA5

536

Q8N3K9
PAFPAKDPDPPYSVE

KANK2

21

Q63ZY3
DKLDFAPPTPPHYPP

DNAAF5

326

Q86Y56
PVVHPSAPAPLPKDY

CLIP3

41

Q96DZ5
PEAAHPAPLYSPTRP

INSM1

91

Q01101
PPHAAAEPDLLYYPP

RXFP3

436

Q9NSD7
ENPELYVPPLAPHPL

AK9

1686

Q5TCS8
PPSVLPDYHLHDPYP

SPATA48

71

A4D263
DEHESPPPEDAPLYP

USP9X

2486

Q93008
YLDPFDAQPHPAPPD

SHD

106

Q96IW2
PPPPYHDALYFPVLI

TMEM151B

526

Q8IW70
PHPSPAAPEPLAYDY

ARHGAP27

81

Q6ZUM4
EDFPYSPLPPEATLP

SMIM28

111

A0A1B0GU29
PPAPHKPLDDVYSLF

SIN3B

761

O75182
VPHPYEPPEPSFDTV

PROB1

691

E7EW31
SDIPPRYPFQALPPH

TNRC18

1076

O15417
EEPSLPFLAYPPPSH

ZFHX2

151

Q9C0A1
DFAPLNPAPYPAPHL

SP7

201

Q8TDD2
FHPTDEAYSPPPAPE

SCAF1

231

Q9H7N4
FHPISDLPPPEPYVQ

WIPF1

456

O43516
DPPLPARLYVHPDSP

TBX20

176

Q9UMR3
PPAPAPPCTDLDLHY

TBKBP1

186

A7MCY6
EHKGPVFAPPYEPLP

TOP1

221

P11387
QFPDELAAYHPTPPL

MYO9A

1796

B2RTY4
LAAYHPTPPLSPELP

MYO9A

1801

B2RTY4