Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

RAB6D RAP1A RAP1B ABCB7 KIF27 DNAH10 ABCB6 RAB6B RAB6C ATP10D DHX15 ARL4C ATP2C1 SUPV3L1 DDX53 GNAI1 GNAI3 KIF13A RAB6A DNAH11

1.46e-0577517420GO:0017111
GeneOntologyMolecularFunctionpyrophosphatase activity

RAB6D RAP1A RAP1B ABCB7 KIF27 DNAH10 ABCB6 RAB6B RAB6C ATP10D DHX15 ARL4C ATP2C1 SUPV3L1 DDX53 GNAI1 GNAI3 KIF13A RAB6A DNAH11

4.48e-0583917420GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

RAB6D RAP1A RAP1B ABCB7 KIF27 DNAH10 ABCB6 RAB6B RAB6C ATP10D DHX15 ARL4C ATP2C1 SUPV3L1 DDX53 GNAI1 GNAI3 KIF13A RAB6A DNAH11

4.56e-0584017420GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

RAB6D RAP1A RAP1B ABCB7 KIF27 DNAH10 ABCB6 RAB6B RAB6C ATP10D DHX15 ARL4C ATP2C1 SUPV3L1 DDX53 GNAI1 GNAI3 KIF13A RAB6A DNAH11

4.56e-0584017420GO:0016818
GeneOntologyMolecularFunctionGTP binding

RAB6D RAP1A RAP1B SAMHD1 LRRK1 RAB6B RAB6C ARL4C ADSS2 GNAI1 GNAI3 RAB6A

1.96e-0439717412GO:0005525
GeneOntologyMolecularFunctionbeta-adrenergic receptor kinase activity

GRK5 GRK6

4.48e-0441742GO:0047696
GeneOntologyMolecularFunctionguanyl ribonucleotide binding

RAB6D RAP1A RAP1B SAMHD1 LRRK1 RAB6B RAB6C ARL4C ADSS2 GNAI1 GNAI3 RAB6A

4.85e-0443917412GO:0032561
GeneOntologyMolecularFunctionguanyl nucleotide binding

RAB6D RAP1A RAP1B SAMHD1 LRRK1 RAB6B RAB6C ARL4C ADSS2 GNAI1 GNAI3 RAB6A

4.85e-0443917412GO:0019001
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ROCK2 CDS1 POLE GRK5 GRK6 DGKQ LRRK1 TIPARP NEK4 PIKFYVE STK11 DGUOK ETNK2 DLG2 EIF2AK4 ATM CTU1 EPHA10 PARP12

5.53e-0493817419GO:0016772
GeneOntologyMolecularFunctionGTPase activating protein binding

FMNL3 GNAI1 GNAI3

5.69e-04191743GO:0032794
GeneOntologyMolecularFunctionG protein-coupled serotonin receptor binding

GNAI1 GNAI3

7.42e-0451742GO:0031821
GeneOntologyCellularComponentG protein-coupled receptor complex

DRD2 GRM1 GPR156

8.75e-05111733GO:0097648
GeneOntologyCellularComponentintegrin alphaIIb-beta3 complex

ITGA2B TSPAN32

2.03e-0431732GO:0070442
DomainP-loop_NTPase

TANC2 ATP6V1B1 RAP1A RAP1B ABCB7 KIF27 DNAH10 MTHFD1L ABCB6 SLFN5 LRRK1 RAB6B RAB6C DHX15 ARL4C ADSS2 CHST15 TJP1 SUPV3L1 DGUOK RAD54B DLG2 DDX53 GNAI1 GNAI3 MYO15A KIF13A RAB6A DNAH11

6.84e-1084817029IPR027417
Domain-

ATP6V1B1 RAP1A RAP1B ABCB7 DNAH10 MTHFD1L ABCB6 SLFN5 LRRK1 RAB6B RAB6C DHX15 ARL4C CHST15 TJP1 SUPV3L1 DGUOK RAD54B DLG2 DDX53 GNAI1 GNAI3 MYO15A RAB6A DNAH11

1.77e-08746170253.40.50.300
DomainGPCR_3

GRM1 GRM4 GPR158 GPR156

3.51e-05211704IPR000337
Domain7tm_3

GRM1 GRM4 GPR158 GPR156

4.26e-05221704PF00003
DomainG_PROTEIN_RECEP_F3_2

GRM1 GRM4 GPR158 GPR156

4.26e-05221704PS00980
DomainG_PROTEIN_RECEP_F3_3

GRM1 GRM4 GPR158 GPR156

4.26e-05221704PS00981
DomainG_PROTEIN_RECEP_F3_1

GRM1 GRM4 GPR158 GPR156

4.26e-05221704PS00979
DomainG_PROTEIN_RECEP_F3_4

GRM1 GRM4 GPR158 GPR156

4.26e-05221704PS50259
DomainGPCR_3_C

GRM1 GRM4 GPR158 GPR156

4.26e-05221704IPR017978
PathwayREACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

RAP1A RAP1B ITGA2B CRK

7.22e-06151244M12101
PathwayREACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

RAP1A RAP1B ITGA2B CRK

7.22e-06151244MM14961
PathwayWP_CHEMOKINE_SIGNALING

ROCK2 RAP1A RAP1B GRK5 GRK6 CRK GNAI1 GNAI3 PREX1

1.49e-051651249M39400
PathwayWP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION

RAP1A RAP1B DRD2 GRM1 GNAI1

2.82e-05411245M39655
PathwayWP_CHEMOKINE_SIGNALING_PATHWAY

ROCK2 RAP1A RAP1B GRK5 GRK6 CRK GNAI1 GNAI3 PREX1

3.53e-051841249MM15943
PathwayKEGG_CHEMOKINE_SIGNALING_PATHWAY

ROCK2 RAP1A RAP1B GRK5 GRK6 CRK GNAI1 GNAI3 PREX1

4.18e-051881249M4844
PathwayREACTOME_INTEGRIN_SIGNALING

RAP1A RAP1B ITGA2B CRK

8.56e-05271244M760
PathwayREACTOME_INTEGRIN_SIGNALING

RAP1A RAP1B ITGA2B CRK

9.92e-05281244MM14958
PathwayREACTOME_MET_ACTIVATES_RAP1_AND_RAC1

RAP1A RAP1B CRK

1.04e-04111243M27776
PathwayREACTOME_MET_ACTIVATES_RAP1_AND_RAC1

RAP1A RAP1B CRK

1.04e-04111243MM15515
PathwayREACTOME_MET_PROMOTES_CELL_MOTILITY

COL5A2 RAP1A RAP1B CRK

1.31e-04301244MM15517
PathwayPID_FAK_PATHWAY

DOCK1 ROCK2 RAP1A RAP1B CRK

1.66e-04591245M281
PathwayBIOCARTA_MET_PATHWAY

DOCK1 RAP1A RAP1B CRK

1.92e-04331244M19358
PathwayWP_HEPATOCYTE_GROWTH_FACTOR_RECEPTOR_SIGNALING

DOCK1 RAP1A RAP1B CRK

2.16e-04341244M39383
PathwayPID_CXCR4_PATHWAY

RAP1B GRK6 CRK ARR3 GNAI1 GNAI3

2.49e-041001246M124
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

DOCK1 ROCK2 RAP1A RAP1B ITGA2B CRK

2.77e-041021246M39577
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

DOCK1 ROCK2 RAP1A RAP1B ITGA2B CRK

2.77e-041021246MM15830
PathwayREACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

RAP1A RAP1B ITGA2B

2.80e-04151243M1262
PathwayREACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

RAP1A RAP1B ITGA2B

2.80e-04151243MM14959
PathwayREACTOME_PLATELET_AGGREGATION_PLUG_FORMATION

RAP1A RAP1B ITGA2B CRK

3.34e-04381244MM15456
PathwayREACTOME_PLATELET_AGGREGATION_PLUG_FORMATION

RAP1A RAP1B ITGA2B CRK

3.70e-04391244M10735
PathwayPID_ECADHERIN_NASCENT_AJ_PATHWAY

RAP1A RAP1B CRK TJP1

3.70e-04391244M156
PathwayWP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER

DOCK1 RAP1A RAP1B CRK RPTOR ATM

4.17e-041101246M48043
PathwayREACTOME_MET_PROMOTES_CELL_MOTILITY

COL5A2 RAP1A RAP1B CRK

4.49e-04411244M27778
PathwayPID_THROMBIN_PAR1_PATHWAY

ROCK2 AKAP13 GNAI1 GNAI3

5.40e-04431244M238
PathwayREACTOME_ARMS_MEDIATED_ACTIVATION

RAP1A CRK

7.54e-0451242MM14671
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DOCK1 CPAMD8 MBTPS1 CDS1 RAP1A ANK3 BLNK NCAM2 ECPAS STEAP2 RAB6B CCNY NIT2 ATP2C1 FAM111A GPR158 TJP1 PTPRS RPTOR LMLN ANKRD17 AKAP13 KDM2A EIF2AK4 MCTP2 THRAP3

3.77e-0814891762628611215
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ZNF326 MTHFD1L ACLY POLE URB2 SRBD1 DIS3 SLC2A1 DHX15 USP5 ADSS2 SUPV3L1 RPTOR PIP ANKRD17 NLE1 AKAP13 KDM2A EIF3A PRPF38A DCTN4 SNRPA1 THRAP3 PARP12

9.98e-0813531762429467282
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TANC2 ARSJ MTHFD1L PHF12 POLE GRK5 GRK6 DGKQ PANX1 LRRK1 SLC2A1 TBC1D9 PIKFYVE CELSR2 CHST15 PTPRS KCNH2 RPTOR NLE1 AKAP13 PREX1

2.20e-0711051762135748872
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

ZNF326 RAP1B KIF27 DNAH10 MTHFD1L ACLY POLE SAMHD1 URB2 GRM1 ECPAS DIS3 SLC2A1 PRDM2 DHX15 ADSS2 SUPV3L1 RPTOR CC2D2A EIF3A ATM SUZ12 SNRPA1 THRAP3

2.57e-0714251762430948266
Pubmed

RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.

RAP1A RAP1B GNAI1 GNAI3

3.04e-0712176410926822
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

ROCK2 RAP1A RAP1B GRK5 GRK6 SRBD1 OR10G7 PHEX STK11 TBC1D31 IFT88 TJP1 LMLN CC2D2A NLE1 DLG2 PABPC1L GNAI1 EIF3A EIF2AK4 GNAI3 ATM PREX1 THRAP3

3.18e-0714421762435575683
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

ROCK2 TPTE ZNF326 MTHFD1L ACLY POLE SAMHD1 ECPAS DIS3 USP5 ATP2C1 PTPRA TJP1 PTPRS ANKRD17 GNAI1 EIF3A GNAI3 SNRPA1

5.87e-079741761928675297
Pubmed

Coupling of dopamine receptor subtypes to multiple and diverse G proteins.

DRD2 GNAI1 GNAI3

1.26e-065176310978845
Pubmed

Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation.

RAP1B ITGA2B GNAI1

2.52e-066176315863506
Pubmed

Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells.

GNAI1 GNAI3 MYO15A

2.52e-066176330975754
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

ROCK2 RAP1B ANK3 PANX1 FMNL3 PTPRA PTPRS DLG2 ELMOD3 GNAI3 IL6ST

3.90e-063771761138117590
Pubmed

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.

DOCK1 RAP1B ECPAS FMNL3 RPTOR GNAI3

6.33e-0689176627034005
Pubmed

Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis.

TJP1 GNAI1 GNAI3

1.05e-059176338651641
Pubmed

Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages.

GRK5 GRK6 ARR3

1.05e-059176318180038
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

ONECUT2 ABCB7 KMT5A SLFN5 URB2 ONECUT1 SLC2A1 CCNY RETREG3 DHX15 ATP2C1 FAM111A TJP1 RPTOR PIP PTRHD1 UGT8 GNAI3 THRAP3

1.24e-0512031761929180619
Pubmed

The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina.

TJP1 GNAI1 GNAI3

1.49e-0510176326755700
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

KMT5A DIS3 CRK DHX15 TJP1 RPTOR ANKRD17 THRAP3

1.50e-05215176835973513
Pubmed

Crk proteins transduce FGF signaling to promote lens fiber cell elongation.

RAP1A RAP1B CRK TJP1

1.79e-0531176429360039
Pubmed

Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form.

RAP1A RAP1B

2.55e-052176213679863
Pubmed

Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function.

RAP1A RAP1B

2.55e-052176225807985
Pubmed

Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population.

RAP1A RAP1B

2.55e-052176234140948
Pubmed

Activated heterotrimeric G protein αi subunits inhibit Rap-dependent cell adhesion and promote cell migration.

RAP1A GNAI1

2.55e-052176229259127
Pubmed

Neutrophil-derived glutamate regulates vascular endothelial barrier function.

GRM1 GRM4

2.55e-052176211847215
Pubmed

Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.

RAP1A RAP1B

2.55e-052176229222111
Pubmed

Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1.

RAP1A RAP1B

2.55e-052176218305243
Pubmed

Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation.

RAB6B RAB6A

2.55e-052176238830762
Pubmed

Expression of protein-tyrosine phosphatases in the major insulin target tissues.

PTPRA PTPRS

2.55e-05217629357975
Pubmed

Mutation in RAP1 is a rare event in myelodysplastic syndromes.

RAP1A RAP1B

2.55e-052176216118622
Pubmed

Mutation analysis of RAP1 gene in papillary thyroid carcinomas.

RAP1A RAP1B

2.55e-052176218948674
Pubmed

Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.

RAB6C RAB6A

2.55e-052176211054569
Pubmed

Expression of Rap 1 suppresses genomic instability of H-ras transformed mouse fibroblasts.

RAP1A RAP1B

2.55e-05217629330640
Pubmed

Dose-dependent regulation of horizontal cell fate by Onecut family of transcription factors.

ONECUT2 ONECUT1

2.55e-052176232790713
Pubmed

Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.

RAP1A RAP1B

2.55e-052176224039860
Pubmed

Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition.

RAP1A RAP1B

2.55e-052176231403469
Pubmed

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

STK11 ATM

2.55e-052176212234250
Pubmed

Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.

RAP1A RAP1B

2.55e-052176218805968
Pubmed

Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response.

GNAI1 GNAI3

2.55e-052176233754034
Pubmed

The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands.

RAP1A RAP1B

2.55e-052176218191594
Pubmed

Loss of neuronatin promotes "browning" of primary mouse adipocytes while reducing Glut1-mediated glucose disposal.

SLC2A1 NNAT

2.55e-052176223482445
Pubmed

Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively.

RAP1A RAP1B

2.55e-05217622108841
Pubmed

Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase.

PIKFYVE STK11

2.55e-052176238743625
Pubmed

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.

RAP1A RAP1B

2.55e-052176218056377
Pubmed

Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions.

RAP1A RAP1B

2.55e-052176218625726
Pubmed

Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

GRK5 GRK6

2.55e-052176217786238
Pubmed

The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.

ATP6V1B1 TRPV5

2.55e-052176219470676
Pubmed

Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.

RAP1A RAP1B

2.55e-05217623141412
Pubmed

Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation.

GRK5 GRK6

2.55e-052176220038610
Pubmed

Prognostic impact of the combination of glucose transporter 1 and ATP citrate lyase in node-negative patients with non-small lung cancer.

ACLY SLC2A1

2.55e-052176225837797
Pubmed

The human genome encodes at least three non-allellic G proteins with alpha i-type subunits.

GNAI1 GNAI3

2.55e-05217622440724
Pubmed

Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.

ADSS2 ATM

2.55e-052176219115993
Pubmed

The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction.

RAP1A RAP1B

2.55e-052176232651478
Pubmed

Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.

GRM1 GRM4

2.55e-052176217446080
Pubmed

Increased prevalence of glycoprotein IIb/IIIa Leu33Pro polymorphism in term infants with grade I intracranial haemorrhage.

ITGA2B F5

2.55e-052176216773503
Pubmed

The C-terminal polyproline-containing region of ELMO contributes to an increase in the life-time of the ELMO-DOCK complex.

DOCK1 ELMOD3

2.55e-052176222177965
Pubmed

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.

RAP1A RAP1B

2.55e-052176226804993
Pubmed

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.

RAP1A RAP1B

2.55e-052176232184389
Pubmed

A region of the third intracellular loop of the short form of the D2 dopamine receptor dictates Gi coupling specificity.

DRD2 GNAI1

2.55e-052176214581469
Pubmed

Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis.

RAP1A RAP1B

2.55e-052176230796637
Pubmed

Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration.

RAP1A RAP1B

2.55e-052176223946483
Pubmed

Rheb binds and regulates the mTOR kinase.

RAP1A RPTOR ATM

2.71e-0512176315854902
Pubmed

Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.

ITGA2B PTAFR TSPAN32 KCNH2 IL9R

2.71e-0569176517192395
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ANK3 MCF2L2 ADGRB3 NCAM2 ZNF879 STAT6 PTPRA IFT88 TJP1 SUPV3L1 LGI3 PCSK6 CEP70 BTG3 DLG2 C1S ATM PREX1 RAB6A

3.05e-0512851761935914814
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ROCK2 TANC2 RAP1A ANK3 ADGRB3 GRM1 GRM4 CELSR2 GPR158 TJP1 PTPRS RPTOR ANKRD17 DLG2 GNAI1 THRAP3

3.41e-059631761628671696
Pubmed

A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells.

TJP1 GNAI1 GNAI3

3.51e-0513176324135232
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

RAP1B ABCB7 ANK3 SLFN12 DIS3 SLC2A1 PRDM2 STAT6 STK11 CDK5RAP3 TBC1D31 ANKRD17 EIF2AK4 GNAI3 PRPF38A KIF13A PARP12

3.96e-0510841761711544199
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ROCK2 TANC2 ANK3 ACLY NCAM2 GRM1 SLC2A1 DHX15 USP5 PTPRA TJP1 PTPRS RPTOR LGI3 DLG2 GNAI1 EIF3A DCTN4 THRAP3 DNAH11

4.11e-0514311762037142655
Pubmed

Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors.

ONECUT2 ONECUT1 TJP1

4.45e-0514176316103213
Pubmed

p130Cas: a versatile scaffold in signaling networks.

RAP1A RAP1B ITGA2B

4.45e-0514176316581250
Pubmed

Integrins and Src: dynamic duo of adhesion signaling.

RAP1A RAP1B ITGA2B

4.45e-0514176316005629
Pubmed

RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.

TJP1 GNAI3 MYO15A

5.54e-0515176336260679
Pubmed

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.

RAP1A RAP1B CRK DHX15 USP5 PYGM EIF3A DCTN4

6.95e-05267176833417871
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

ROCK2 RAP1B MTHFD1L ECPAS RAB6B DIS3 SLC2A1 DHX15 USP5 CDK5RAP3 ADSS2 TJP1 SUPV3L1 ANKRD17 GNAI1 EIF3A GNAI3 SNRPA1 THRAP3

6.96e-0513671761932687490
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

DOCK1 TANC2 ZNF326 ACLY MCF2L2 NCAM2 ECPAS RAB6B CRK ARID3B PIP AKAP13 PRPF38A PREX1 RAB6A

7.11e-059161761532203420
Pubmed

Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.

RAP1A RAP1B

7.61e-053176224642466
Pubmed

Rap1 signaling prevents L-type calcium channel-dependent neurotransmitter release.

RAP1A RAP1B

7.61e-053176223616533
Pubmed

Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins.

GNAI1 GNAI3

7.61e-053176216962188
Pubmed

Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6.

GRK5 GRK6

7.61e-05317627789183
Pubmed

The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse.

RAP1A CRK

7.61e-053176228790195
Pubmed

G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

GRK5 GRK6

7.61e-053176219801552
Pubmed

Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice.

RAP1A RAP1B

7.61e-053176238010922
Pubmed

Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton.

RAP1B ITGA2B

7.61e-053176211994301
Pubmed

Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis.

RAP1A RAP1B

7.61e-053176232539601
Pubmed

Rab6 family proteins interact with the dynein light chain protein DYNLRB1.

RAB6B RAB6A

7.61e-053176218044744
Pubmed

Preferential Coupling of Dopamine D2S and D2L Receptor Isoforms with Gi1 and Gi2 Proteins-In Silico Study.

DRD2 GNAI1

7.61e-053176231936673
Pubmed

The role of Crk/Dock180/Rac1 pathway in the malignant behavior of human ovarian cancer cell SKOV3.

DOCK1 CRK

7.61e-053176220237902
Pubmed

Dysfunction of the PI3 kinase/Rap1/integrin α(IIb)β(3) pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia.

RAP1A ITGA2B

7.61e-053176223243278
Pubmed

The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.

ABCB7 ABCB6

7.61e-053176216467350
Pubmed

DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.

DOCK1 CRK

7.61e-05317628657152
Pubmed

Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.

ACLY SLC2A1

7.61e-053176237747441
Pubmed

Rap1 and its effector RIAM are required for lymphocyte trafficking.

RAP1A RAP1B

7.61e-053176226324702
Pubmed

OC-3, a novel mammalian member of the ONECUT class of transcription factors.

ONECUT2 ONECUT1

7.61e-053176211944891
Pubmed

Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria.

GNAI1 GNAI3

7.61e-053176229342363
Pubmed

Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).

RAP1A RAP1B

7.61e-053176222577140
Pubmed

Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells.

KCNH2 GNAI3

7.61e-053176237923359
Pubmed

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.

RAD54B ATM

7.61e-053176219061978
Pubmed

Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B.

RAP1A RAP1B

7.61e-053176227760305
Pubmed

Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31.

TIPARP PARP12

7.61e-053176212851707
Pubmed

An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions.

RAP1A PTPRA

7.61e-053176225631816
Pubmed

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.

GNAI1 GNAI3

7.61e-053176230836096
Pubmed

Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus.

GNAI1 GNAI3

7.61e-053176229507199
GeneFamilySchlafen family

SLFN12 SLFN5

9.58e-04712421110
GeneFamilyG protein-coupled receptors, Class C orphans

GPR158 GPR156

9.58e-0471242285
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM1 GRM4

1.27e-0381242281
GeneFamilyCUT class homeoboxes and pseudogenes

ONECUT2 ONECUT1

1.63e-0391242527
GeneFamilyProprotein convertase subtilisin/kexin family

MBTPS1 PCSK6

1.63e-0391242973
GeneFamilyATP binding cassette subfamily B

ABCB7 ABCB6

2.46e-03111242806
CoexpressionMARTINEZ_RESPONSE_TO_TRABECTEDIN_DN

RAP1B PANX1 DIS3 SLC2A1 CRK RNF14 SUPV3L1 RAD54B EIF3A RAB6A THRAP3

2.22e-0627217411M15123
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

DOCK1 ROCK2 COL5A2 RAP1A GRK5 TIPARP DHX15 NEK4 PIKFYVE PPP2R5A ATP2C1 PTPRA TBC1D31 ANKRD17 AKAP13 GNAI1 EIF3A SUZ12 RAB6A

4.55e-0685617419M4500
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

RAP1A ZNF326 KMT5A PHF12 CRK PRDM2 CCNY BCO1 TBC1D31 CELSR2 LMLN KDM2A GNAI1 EIF2AK4 GNAI3 PRPF38A

2.29e-0559516916Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#5

ROCK2 ABCB7 FHOD3 ECPAS NEK4 CELSR2 PAPPA EIF3A ATM

3.88e-052041699Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_1000_K5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 CPAMD8 ARSJ ANK3 BLNK SYT9 FHOD3 TBC1D9 DLG2 PAPPA

2.93e-0918317410b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ONECUT2 FAT4 EFCAB6 DNAH10 NCAM2 GRM1 MYO15A USH2A EPHA10 DNAH11

3.09e-09184174102cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ONECUT2 FAT4 EFCAB6 DNAH10 NCAM2 GRM1 MYO15A USH2A EPHA10 DNAH11

3.09e-0918417410ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ONECUT2 FAT4 EFCAB6 DNAH10 NCAM2 GRM1 MYO15A USH2A EPHA10 DNAH11

3.09e-09184174102b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROCK2 COL5A2 RAP1B CRK DHX15 ADSS2 EIF3A GNAI3 RAB6A IL6ST

5.67e-0919617410151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 CPAMD8 ARSJ ANK3 BLNK SYT9 FHOD3 DLG2 PAPPA

5.53e-081871749e3095455d2f255854f339f6b05fa87852af0700f
ToppCellRA-02._Fibroblast_II|RA / Chamber and Cluster_Paper

COL5A2 MTHFD1L GRK5 ADGRB3 NCAM2 SAMHD1 PTPRS C1S PAPPA

7.91e-0819517496a02ebbeb3199447ddce64d92d8809436e040eba
ToppCellMesenchymal_cells-Osteoblasts|Mesenchymal_cells / Lineage and Cell class

COL5A2 DCBLD1 FHOD3 FMNL3 PHEX PTPRS KCNH2 PREX1

6.40e-071831748d6b52d52fe9a7a6c798947f05420d79fe12e4662
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CPAMD8 ARSJ ANK3 BLNK SYT9 FHOD3 TBC1D9 DLG2

6.95e-071851748d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCellRV-01._Fibroblast_I|RV / Chamber and Cluster_Paper

COL5A2 GRK5 ADGRB3 NCAM2 SAMHD1 PTPRS C1S PAPPA

9.19e-071921748356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCellRV-02._Fibroblast_II|RV / Chamber and Cluster_Paper

COL5A2 GRK5 ADGRB3 NCAM2 SAMHD1 PTPRS C1S PAPPA

9.94e-07194174811c79a8c56ece42713b04b321982e41e239f07a5
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK1 ANK3 SYT9 LGI3 UGT8 DLG2 GNAI1 SEC14L5

9.94e-071941748cb0422e7607dbd77204428b7e2c70dfe14a6ca11
ToppCellfacs-Trachea-nan-3m|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROCK2 COL5A2 MBTPS1 CRK TIPARP PTPRA GNAI3 RAB6A

1.12e-0619717480353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

COL5A2 ADGRB3 NCAM2 STEAP2 PTPRS DLG2 C1S PAPPA

1.12e-061971748fb847f2277609c31fffcdf49517243ce0684facf
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

TANC2 COL5A2 FAT4 ANK3 NCAM2 STEAP2 DLG2 MCTP2

1.12e-061971748f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

COL5A2 ADGRB3 NCAM2 STEAP2 PTPRS DLG2 C1S PAPPA

1.16e-061981748df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

FAT4 ADGRB3 NCAM2 STEAP2 PHEX PTPRS C1S GNAI1

1.25e-062001748aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

FAT4 ADGRB3 NCAM2 STEAP2 PHEX PTPRS C1S GNAI1

1.25e-062001748a510deaada669e690329183e18df02870bd204b3
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FAT4 ADGRB3 NCAM2 STEAP2 PHEX PTPRS C1S GNAI1

1.25e-062001748dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AADAC ZNF326 LRRK1 ZNF879 MSL2 GNAI1 DNAH11

4.49e-061681747d69452e2cfeb74023b5cf3d09064d7dcad0008ec
ToppCellControl-Lymphoid-pDC|Control / Condition, Lineage and Cell class

CETP BLNK SLC2A1 PHEX ARL4C PTPRS CCDC152

6.09e-0617617475de16ff65476bde8b23322a44e11412e14f1bafe
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_CTXN3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ONECUT2 COL5A2 GRM1 STEAP2 RAD54B KIF13A EPHA10

6.32e-06177174796d639407f79669f3990138793d157b94273581c
ToppCellGlobus_pallidus-Neuronal-Inhibitory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DGKQ FHOD3 GRM1 RNF14 ARL4C KCNH2 EPHA10

7.58e-06182174704ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CPAMD8 ANK3 BLNK SYT9 FHOD3 DLG2 PAPPA

9.70e-0618917473a295c215b5c18e7c673f92b7af5be523421682c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CPAMD8 ANK3 BLNK SYT9 FHOD3 DLG2 PAPPA

9.70e-061891747fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CPAMD8 ANK3 SYT9 NCAM2 FHOD3 TBC1D9 DLG2

1.07e-0519217470bb06738e1c3ec0c044a7ee61f6cf1d4781fb53c
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANK3 TJP1 LGI3 UGT8 DLG2 GNAI1 SEC14L5

1.07e-0519217473ce5dbde41aeb73d49f2c7991d34682f0827fa5a
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

COL5A2 ADGRB3 NCAM2 STEAP2 PHEX PTPRS C1S

1.11e-051931747ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellLV-01._Fibroblast_I|LV / Chamber and Cluster_Paper

COL5A2 GRK5 ADGRB3 NCAM2 PTPRS C1S PAPPA

1.11e-051931747dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCellproximal-3-Hematologic-IGSF21+_Dendritic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

BLNK LRRK1 URB2 F5 TBC1D31 ATM PARP12

1.19e-0519517478592d0332bc82a91e173680cfd1afc5ee189b289
ToppCellCOVID-19-Heart-Fib_1|Heart / Disease (COVID-19 only), tissue and cell type

COL5A2 ARSJ GRK5 ADGRB3 NCAM2 PCSK6 C1S

1.19e-051951747f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCellproximal-Hematologic-IGSF21+_Dendritic|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

BLNK LRRK1 URB2 F5 TBC1D31 ATM PARP12

1.19e-051951747c48ff83c48342875f06c6c9e7d5bc6084a992848
ToppCellRV-02._Fibroblast_II|World / Chamber and Cluster_Paper

COL5A2 GRK5 ADGRB3 NCAM2 PTPRS PCSK6 PAPPA

1.19e-051951747ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCellproximal-Hematologic-IGSF21+_Dendritic-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

BLNK LRRK1 URB2 F5 TBC1D31 ATM PARP12

1.19e-051951747ae9d61011e95f7840cbb154738c79745fd29943e
ToppCellRA-02._Fibroblast_II|World / Chamber and Cluster_Paper

MTHFD1L GRK5 ADGRB3 NCAM2 SAMHD1 PTPRS PAPPA

1.23e-051961747e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

COL5A2 ADGRB3 NCAM2 STEAP2 DLG2 C1S PAPPA

1.27e-051971747f1c8936986123a3151140c374fcd62d6705c530b
ToppCellfacs-Trachea-3m|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ROCK2 COL5A2 MBTPS1 CRK PTPRA GNAI3 RAB6A

1.27e-051971747e77016d64b1cac9825fec7cfe5071f1567401187
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TANC2 AADAC CDS1 ARSJ ANK3 LGI3 BTG3

1.31e-051981747aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

TANC2 SLFN5 CHST15 TJP1 LMLN PTRHD1 SUZ12

1.31e-05198174776d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CELSR2 TJP1 PTPRS LGI3 UGT8 DLG2 GNAI1

1.35e-0519917475d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CELSR2 TJP1 PTPRS LGI3 UGT8 DLG2 GNAI1

1.35e-0519917479dd4b17fb8c70ab9e126b23b72600463f3db832d
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CELSR2 TJP1 PTPRS LGI3 UGT8 DLG2 GNAI1

1.35e-0519917476fb5f931e6217142de38c1fffc011e63bda4772b
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CELSR2 TJP1 PTPRS LGI3 UGT8 DLG2 GNAI1

1.35e-0519917471bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCellfacs-Brain_Non-Myeloid-Hippocampus|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACLY NCAM2 PTPRA PCSK6 UGT8 KIF13A RAB6A

1.40e-052001747fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SAMHD1 SLFN5 PRDM2 AKAP13 KDM2A EIF3A ATM

1.40e-05200174712f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL5A2 FAT4 ADGRB3 NCAM2 STEAP2 PTPRS PAPPA

1.40e-052001747cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

GRK6 PANX1 PTAFR NEK4 STK11 TBC1D31 CHST15

1.40e-052001747f11ae9055e72c938b6c9e52701478b2eee681ac4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANK3 DMRT2 LGI3 UGT8 DLG2 GNAI1 SEC14L5

1.40e-052001747829978708463a7459fe1041bd90196775bc4b531
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SAMHD1 SLFN5 F5 ARL4C PTPRA IL6ST

2.77e-051501746c922dbb4c9c12ccf08bd5f6168b20606c605d052
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

ZNF326 BLNK CEP70 AKAP13 PRPF38A THRAP3

4.26e-051621746810881210e015c788814e4fe8d7a24c929cf2621
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAT4 MCF2L2 ABCB6 DIS3 RETREG3 C1S

5.05e-051671746b742558ca92985db0a67c88f530bc375f3d3bb98
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POLE SLFN5 ONECUT1 ZNF879 TJP1 RPTOR

5.05e-051671746774f3264318b002d0df5d06d41d645366038d0bf
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|368C / Donor, Lineage, Cell class and subclass (all cells)

ZNF326 MCF2L2 TSPAN32 RPTOR PABPC1L GNAI1

5.39e-0516917460d96c0b4fd26fbc0bf44ff7bed2936eebcc55b74
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL5A2 FAT4 SAMHD1 C1S PAPPA IL6ST

5.39e-051691746c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

COL5A2 MTHFD1L ADGRB3 NCAM2 SAMHD1 PTPRS

5.39e-0516917466373562ab3b1765060212a6a53d6543e7e942e80
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRB3 SAMHD1 LRRK1 FMNL3 PHEX PTPRS

5.76e-051711746af1c93eb75f45c042ea475d93db56e4da207e31f
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DGKQ GRM1 STEAP2 RNF14 KCNH2 EPHA10

6.14e-0517317467e3897868dd3f6e4974f593c60649a543ffc8693
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

AADAC DCBLD1 STEAP2 DNAJC28 PTPRS LGI3

6.14e-051731746ef8d720b99470fe1953661f6e66bc0366266bdb6
ToppCellControl-Myeloid-pDC|Control / Disease group,lineage and cell class (2021.01.30)

BLNK SLC2A1 PHEX ARL4C PTPRS CCDC152

6.75e-051761746baa3563973ea1a351fe028f55828463d2a51bf1a
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

COL5A2 AADAC FAT4 STEAP2 PCSK6 PAPPA

6.97e-0517717463d955ea938a1d2fb1b6d68d4997fd454bd632dfc
ToppCellCiliated_cells-A-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

EFCAB6 DNAH10 DCDC2B PIP VWA3B DNAH11

7.19e-051781746255473ee6df8a13079fb3bb61038162a40cb4c2c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RAP1B ANK3 BLNK FHOD3 TBC1D9 PAPPA

7.41e-051791746d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

COL5A2 GRK5 ADGRB3 NCAM2 PTPRS PCSK6

7.41e-051791746dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POLE SLFN12 RAB6B TIPARP C1S ATM

7.88e-051811746274c0b768925cd5804483303f8c5ebd17a534c41
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-5|TCGA-Colorectal / Sample_Type by Project: Shred V9

CDS1 ARSJ ATP2C1 UGT8 MCTP2 EPHA10

7.88e-0518117468fcc9e77fee7c248df26b6c59b10e672242e2084
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 BLNK FHOD3 TBC1D9 DLG2 PAPPA

7.88e-051811746aa233b652921848af2257cc3687a7a09c3acfb67
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MORC1 SAMHD1 SLFN5 ARL4C GNAI1 IL6ST

8.12e-051821746b86690c109cdc16844a6cd2216c1bf2bf28efd45
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EFCAB6 DNAH10 DCDC2B CC2D2A VWA3B DNAH11

8.89e-0518517465e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellCOVID-19-Fibroblasts-Adventitial_FB|COVID-19 / group, cell type (main and fine annotations)

COL5A2 STEAP2 PTPRS DLG2 C1S PAPPA

8.89e-051851746a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 CPAMD8 ARSJ BLNK DMRT2 TRPV5

8.89e-0518517463d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell5'-Adult-LargeIntestine-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL5A2 ANK3 ADGRB3 NCAM2 SAMHD1 PAPPA

8.89e-051851746f607b6ee579562e2f92103fa5c7053df0170a229
ToppCell5'-Adult-LargeIntestine-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL5A2 ANK3 ADGRB3 NCAM2 SAMHD1 PAPPA

8.89e-051851746317f2c854f00aa5957319b818c85eeed7d72ec7f
ToppCell5'-Adult-LargeIntestine-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL5A2 ANK3 ADGRB3 NCAM2 SAMHD1 PAPPA

8.89e-0518517467bb8fdfe04f85d25056380ec58222366de323a21
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RAP1B SLFN5 ARL4C TBC1D31 ATM MCTP2

9.16e-051861746fc0b488c201a32d829047b58460297df2818b45d
ToppCellCiliated_cells-B-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

EFCAB6 DNAH10 DCDC2B PIP VWA3B DNAH11

9.16e-051861746f72267d533fd0c5280d9741ceee3dd116300a7e4
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TANC2 ANK3 MTHFD1L CEP70 DLG2 MCTP2

9.16e-051861746acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D175|Adult / Lineage, Cell type, age group and donor

COL5A2 ADGRB3 NCAM2 STEAP2 PTPRS PAPPA

9.43e-051871746e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCellCOVID-19-kidney-CD-PC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ANK3 BLNK FHOD3 SLC2A1 PAPPA TRPV5

9.71e-0518817468f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell10x5'v1-week_17-19-Hematopoietic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RAP1B ITGA2B TSPAN32 RAB6B KCNH2 SEC14L5

9.71e-051881746c00ba0abd0c7bb2c8f9166a2ac6220aae4f4d857
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 SAMHD1 SLFN5 ARL4C ATM IL6ST

1.00e-0418917469ab77c6fcb573854da5922412f53d2168bda6b58
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 SAMHD1 SLFN5 ARL4C ATM IL6ST

1.00e-0418917465a9e2ca9a9ee2dc37ab9147a902115a9f1a80169
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 TIPARP ETNK2 CEP70 AKAP13 SLC5A12

1.00e-041891746a48df46274d51e84ffb40264646de7346104efb9
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL5A2 ADGRB3 PHEX PTPRS C1S PAPPA

1.00e-0418917462a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CPAMD8 ANK3 BLNK SYT9 DMRT2 PAPPA

1.00e-041891746532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D175|Adult / Lineage, Cell type, age group and donor

COL5A2 NCAM2 STEAP2 PTPRS C1S PAPPA

1.03e-0419017467dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 BLNK FHOD3 PTAFR TBC1D9 TRPV5

1.03e-0419017464836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL5A2 MTHFD1L LRRK1 STEAP2 C1S PAPPA

1.03e-0419017460fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCellFetal_29-31_weeks-Immune-natural_killer_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TSPAN32 ARL4C TBC1D31 ATM MCTP2 PREX1

1.06e-0419117465696e2e2db7b898a1c7ab3582ae74cb712dd5bdf
ToppCellControl-pDC|Control / Disease condition and Cell class

BLNK SLC2A1 FMNL3 PHEX PTPRS CCDC152

1.06e-041911746543e1437a52d04436862dd1c27b4fae95c44fcc8
ToppCellControl-pDC-|Control / Disease condition and Cell class

BLNK SLC2A1 FMNL3 PHEX PTPRS CCDC152

1.06e-0419117461d7b0fae4d114d6db933c18b4eb2066ffa61356d
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TSPAN32 ARL4C TBC1D31 ATM MCTP2 PREX1

1.06e-0419117469b8b64a36e27a2523b8730c7922fd7ad865a021e
ToppCellLV-02._Fibroblast_II|World / Chamber and Cluster_Paper

COL5A2 GRK5 ADGRB3 NCAM2 PCSK6 C1S

1.06e-041911746d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCellRV-01._Fibroblast_I|World / Chamber and Cluster_Paper

COL5A2 GRK5 ADGRB3 NCAM2 PTPRS PCSK6

1.06e-04191174670c067c54084bfb02c29bab085f4defd477194fb
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL5A2 FAT4 ADGRB3 NCAM2 STEAP2 PTPRS

1.06e-0419117466688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CPAMD8 ANK3 BLNK TBC1D9 DMRT2 PAPPA

1.09e-04192174640f44ac4ab673ee6156abdd2074a60b9de3281ad
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 FHOD3 ANKRD17 DLG2 AKAP13 SLC5A12

1.09e-041921746e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell15-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

CDS1 DNAH10 DCDC2B CC2D2A VWA3B DNAH11

1.12e-041931746aa3acc7571405169efb656d214f3a8cbf988362e
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL5A2 GRK5 ADGRB3 NCAM2 PHEX PTPRS

1.12e-04193174699525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

COL5A2 FAT4 STEAP2 DLG2 C1S PAPPA

1.12e-041931746e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellCOVID-19-kidney-CD-PC|kidney / Disease (COVID-19 only), tissue and cell type

TANC2 ANK3 BLNK SLC2A1 PAPPA TRPV5

1.12e-041931746738689d009e4b118d7ce3171a207294b95cbe78b
DrugDebrisoquin sulfate [581-88-4]; Up 200; 9uM; HL60; HG-U133A

ROCK2 ANK3 GRK5 GRK6 TSPAN32 GRM4 RAB6B CELSR2 KDM2A PARP12

2.80e-06197173101591_UP
DrugSulindac [38194-50-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A

ECPAS PRDM2 PHEX ARL4C ARR3 ETNK2 NLE1 KDM2A NNAT KIF13A

2.80e-06197173101693_UP
Drugguanine

DOCK1 RAP1A RAP1B DRD2 GRK5 GRK6 MCF2L2 GRM1 CRK STK11 ARL4C ADSS2 DGUOK LMLN UGT8 AKAP13 GNAI1 GNAI3 NNAT PREX1 RAB6A

5.28e-0690217321CID000000764
Drugirinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A

ROCK2 TBC1D9 CRK PRDM2 NEK4 CHST15 TJP1 RAD54B AKAP13

1.15e-0518317397498_DN
DrugAjmaline [4360-12-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A

ONECUT2 BLNK ATP10D BCO1 DNAJC28 KCNH2 PCSK6 ATM NNAT

1.76e-0519317392899_UP
DrugClozapine [5786-21-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A

ONECUT2 DRD2 GRK5 ECPAS RAB6B KCNH2 PIP ATM IL6ST

1.91e-0519517395265_UP
DrugNicergoline; Down 200; 8.2uM; PC3; HT_HG-U133A

POLE GRK6 ATP10D PRDM2 USP5 ANKRD17 AKAP13 KDM2A EIF3A

1.99e-0519617392058_DN
DrugTiapride hydrochloride [51012-33-0]; Up 200; 11uM; HL60; HT_HG-U133A

GRK5 LRRK1 URB2 ECPAS ATP2C1 PTPRA TJP1 PCSK6 NLE1

1.99e-0519617392331_UP
DiseaseDeoxyguanosine Kinase Deficiency

SAMHD1 DGUOK

3.38e-0521722C3711385
Diseaseretinal degeneration (implicated_via_orthology)

RAB6D RAB6B RAB6C RAB6A

4.00e-05331724DOID:8466 (implicated_via_orthology)
DiseaseKabuki make-up syndrome

RAP1A RAP1B

2.01e-0441722C0796004
DiseaseStomach Carcinoma

POLE STK11 ATM

2.40e-04211723C0699791
Diseaseactivating signal cointegrator 1 complex subunit 1 measurement

GRK6 PIKFYVE

3.34e-0451722EFO_0801340
Diseasechronotype measurement, sun exposure measurement

ARSJ UGT8

3.34e-0451722EFO_0008328, EFO_0010729
Diseasepartial thromboplastin time

GRK6 F5 C1S

3.60e-04241723EFO_0004310
Diseaseazoospermia (implicated_via_orthology)

DMRT2 PTPRS SNRPA1

5.14e-04271723DOID:14227 (implicated_via_orthology)
DiseaseParkinson's disease (biomarker_via_orthology)

DRD2 GRK5 GRK6

7.04e-04301723DOID:14330 (biomarker_via_orthology)
Diseaseheart conduction disease (implicated_via_orthology)

PHEX KCNH2 ETNK2

8.53e-04321723DOID:10273 (implicated_via_orthology)
DiseaseColorectal Carcinoma

CPAMD8 MTHFD1L POLE MCF2L2 SYT9 ABCB6 GRM1 F5 STK11 PTPRS KDM2A IL6ST

8.92e-0470217212C0009402
DiseaseMcCune Albright syndrome (implicated_via_orthology)

GNAI1 GNAI3

9.24e-0481722DOID:1858 (implicated_via_orthology)
Diseaseendometrial cancer (implicated_via_orthology)

POLE STK11

9.24e-0481722DOID:1380 (implicated_via_orthology)
Diseasecholesteryl esters to total lipids in very large HDL percentage

CETP MSL2 CELSR2

1.21e-03361723EFO_0022257
Diseasecholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

KIF27 DNAH10 CETP DGKQ MSL2 CELSR2 PCSK6

1.22e-032761727EFO_0004612, EFO_0020943
DiseaseCataract

CPAMD8 SLC2A1 ATM

1.31e-03371723C0086543
Diseasehemorrhoid

COL5A2 DCBLD1 SRBD1 PAPPA MYO15A

1.74e-031471725EFO_0009552
Diseaseanti-SARS-CoV-2 IgG measurement, response to COVID-19 vaccine

FHOD3 FMNL3

1.79e-03111722EFO_0803358, EFO_0803362
Diseasevascular endothelial growth factor D measurement

GRK6 PCSK6

1.79e-03111722EFO_0010575
Diseaseautosomal dominant nonsyndromic deafness (is_implicated_in)

ELMOD3 EPHA10

1.79e-03111722DOID:0050564 (is_implicated_in)
Diseasequality of life during menstruation measurement, acne

FHOD3 FMNL3

1.79e-03111722EFO_0003894, EFO_0009366
Diseaseosteoarthritis

DNAH10 KMT5A NCAM2 SRBD1 PRDM2 DLG2

1.98e-032221726MONDO_0005178
Diseasecholesteryl esters to total lipids in small HDL percentage

CETP CELSR2 PCSK6

2.02e-03431723EFO_0022254
Diseasegranulins measurement

ITGA2B CELSR2

2.15e-03121722EFO_0008141
Diseasephospholipids:total lipids ratio, high density lipoprotein cholesterol measurement

CETP DGKQ MSL2 NEK4 CELSR2 PCSK6 DNAH11

2.24e-033071727EFO_0004612, EFO_0020946
Diseaseoptic disc area measurement

ARSJ F5 UGT8

2.31e-03451723EFO_0006937
DiseaseGastric Adenocarcinoma

GRK6 ATM EPHA10

2.31e-03451723C0278701
Diseasesmall vessel stroke

FAT4 ONECUT1 ARL4C DLG2

2.44e-03961724EFO_1001504
Diseasetransmembrane protein 87B measurement

GRK6 PCSK6

2.53e-03131722EFO_0802158
DiseaseT-cell surface glycoprotein CD3 epsilon chain measurement

F5 PIKFYVE

2.53e-03131722EFO_0802114
DiseaseAlzheimer disease, dementia, family history of Alzheimer’s disease

DCBLD1 FHOD3 FMNL3

2.78e-03481723EFO_0009268, MONDO_0001627, MONDO_0004975
Diseaseblood cobalt measurement

F5 RPTOR CC2D2A USH2A

2.93e-031011724EFO_0007577
DiseaseTobacco Dependence

DRD2 RPTOR

2.94e-03141722C0040332
DiseaseNicotine Dependence

DRD2 RPTOR

2.94e-03141722C0028043
Diseaseesterified cholesterol measurement, low density lipoprotein cholesterol measurement

CELSR2 ANKRD17

2.94e-03141722EFO_0004611, EFO_0008589
DiseaseNicotine Use Disorder

DRD2 RPTOR

2.94e-03141722C0376384
Diseasecholesteryl esters to total lipids in small VLDL percentage

CETP CELSR2 PCSK6

2.95e-03491723EFO_0022256
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

KIF27 DNAH10 CETP MSL2 CELSR2 PCSK6

3.10e-032431726EFO_0004612, EFO_0020944
Diseasecholesterol to total lipids in small HDL percentage

CETP CELSR2 PCSK6

3.30e-03511723EFO_0022240
Diseasecholesterol to total lipids in small VLDL percentage

CETP CELSR2 PCSK6

3.30e-03511723EFO_0022242
DiseaseHypertriglyceridemia

CETP CELSR2

3.37e-03151722C0020557
Diseasemelanoma

FAT4 DCBLD1 STK11 DLG2 ATM SUZ12

3.43e-032481726C0025202
Diseaseurate measurement, bone density

ATP6V1B1 MTHFD1L ADGRB3 TIPARP CEP70 DLG2 VWA3B EIF2AK4 USH2A DNAH11

3.55e-0361917210EFO_0003923, EFO_0004531
DiseaseTremor, Rubral

ABCB7 SLC2A1

3.84e-03161722C0750940
DiseaseAtaxia, Appendicular

ABCB7 SLC2A1

3.84e-03161722C0750937
DiseaseAtaxia, Motor

ABCB7 SLC2A1

3.84e-03161722C0278161
Diseaseinterferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement

F5 PCSK6

3.84e-03161722EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
Diseaseidiopathic scoliosis (implicated_via_orthology)

MBTPS1 DNAH10

3.84e-03161722DOID:0060250 (implicated_via_orthology)
DiseaseAtaxia, Sensory

ABCB7 SLC2A1

3.84e-03161722C0240991
DiseaseBlood Coagulation Disorders

COL5A2 F5

3.84e-03161722C0005779
DiseaseAbnormal coordination

ABCB7 SLC2A1

3.84e-03161722C0520966
DiseaseAtaxia, Truncal

ABCB7 SLC2A1

3.84e-03161722C0427190
Diseasecorneal topography

LRRK1 TJP1 AKAP13 EIF2AK4

3.86e-031091724EFO_0004345
Diseasetriglycerides in medium VLDL measurement

DNAH10 CETP CELSR2

4.09e-03551723EFO_0022155
Diseaseresponse to tenofovir, creatinine clearance measurement

DCBLD1 FHOD3 FMNL3 PREX1

4.25e-031121724EFO_0007934, EFO_0009279
DiseaseBenign neoplasm of stomach

POLE ATM

4.34e-03171722C0153943
DiseaseTactile Amnesia

GNAI1 GNAI3

4.34e-03171722C0750906
DiseaseAmnestic State

GNAI1 GNAI3

4.34e-03171722C0750907
DiseaseDissociative Amnesia

GNAI1 GNAI3

4.34e-03171722C0236795
DiseaseNeoplasm of uncertain or unknown behavior of stomach

POLE ATM

4.34e-03171722C0496905
DiseaseHysterical amnesia

GNAI1 GNAI3

4.34e-03171722C0233750
DiseaseTemporary Amnesia

GNAI1 GNAI3

4.34e-03171722C0233796
DiseaseCarcinoma in situ of stomach

POLE ATM

4.34e-03171722C0154060
DiseaseAmnesia

GNAI1 GNAI3

4.34e-03171722C0002622
Diseasealpha-L-iduronidase measurement

RNF212 DGKQ

4.34e-03171722EFO_0020139
DiseaseGlobal Amnesia

GNAI1 GNAI3

4.34e-03171722C0262497
Diseasecholesterol to total lipids in chylomicrons and extremely large VLDL percentage

CETP CELSR2

4.34e-03171722EFO_0022232
Diseasetriglycerides to total lipids in small VLDL percentage

CETP CELSR2 PCSK6

4.75e-03581723EFO_0022338
Diseaseprogression free survival, ovarian carcinoma

FHOD3 FMNL3

4.86e-03181722EFO_0001075, EFO_0004920
Diseasevery low density lipoprotein cholesterol measurement, esterified cholesterol measurement

CETP CELSR2

4.86e-03181722EFO_0008317, EFO_0008589
Diseaseadverse effect, response to xenobiotic stimulus

FHOD3 FMNL3 VWA3B

4.98e-03591723EFO_0009658, GO_0009410
Diseasehydrocephalus (implicated_via_orthology)

KIF27 CELSR2

5.41e-03191722DOID:10908 (implicated_via_orthology)
Diseasesodium-coupled monocarboxylate transporter 1 measurement

CETP CELSR2

5.41e-03191722EFO_0802076
Diseaseblood nickel measurement

F5 RPTOR KIF13A USH2A

5.42e-031201724EFO_0007583
Diseasered blood cell density measurement

ARSJ DNAH10 TSPAN32 PCSK6 UGT8 CC2D2A AKAP13 KDM2A EIF2AK4 MYO15A PREX1 SMIM19

5.64e-0388017212EFO_0007978
DiseaseSchizophrenia

DRD2 ANK3 GRK6 ETNPPL GRM1 GRM4 PTPRA ADSS2 KCNH2 DLG2 ATM MCTP2

5.79e-0388317212C0036341
Diseaselymphocyte percentage of leukocytes

KMT5A GRK5 SAMHD1 LRRK1 TSPAN32 SLC2A1 CRK MSL2 STK11 PREX1

5.82e-0366517210EFO_0007993

Protein segments in the cluster

PeptideGeneStartEntry
VFQTYAKLRQVPRLF

URB2

456

Q14146
REAQFLYAQKLVTQP

ARID3B

36

Q8IVW6
KVIQTAFQRASYPDI

CETP

46

P11597
RQQKVIPVVNSFYAA

ELMOD3

276

Q96FG2
YRLKFNEFVNTVPTI

ARL4C

31

P56559
PFLKAVLRQERVSLY

CDS1

336

Q92903
YAVKRIPINPASRQF

EIF2AK4

616

Q9P2K8
FNNILVRVYVPKRKS

AADAC

86

P22760
LQYDKNFIQIRRVFP

ADGRB3

121

O60242
VITFVRYNDTPIVKA

GRM4

606

Q14833
QAVPIETRRYALKNV

FAT4

1501

Q6V0I7
VTQRITKYPVLFQRI

AKAP13

2146

Q12802
YFRVTLLKATPVQVD

DGKQ

876

P52824
LQARKPVQIFERSVY

DGUOK

131

Q16854
KFYNTPARVIVLLQE

DNAH11

376

Q96DT5
RALNVLVPIFYRNIV

ABCB6

276

Q9NP58
PEQKQIYRFVRTLFS

CCNY

166

Q8ND76
APQFSEKRYVVQVRE

CELSR2

396

Q9HCU4
VVRYLVKEVNQFPSD

ANKRD17

1401

O75179
FAKQKVYNPRIRVES

DHX15

441

O43143
KRSRFQFLYDVQVPI

MTHFD1L

851

Q6UB35
QFLYDVQVPIVDKIR

MTHFD1L

856

Q6UB35
FRKDLYVQTLQVVPA

ARR3

71

P36575
QLSQIVPKVAVFYRA

ATP2C1

606

P98194
FASDPIKIVRAQRQY

ETNPPL

26

Q8TBG4
KVIVSLQYPQDLRAR

ARMC12

311

Q5T9G4
IRTTKYTLLNFVPRN

ATP10D

76

Q9P241
RVIQKRVPNAYDKTA

CRK

241

P46108
FILRRTQEIINKYLP

RAD54B

526

Q9Y620
EIFYDLVRQINRKTP

RAP1A

156

P62834
EIFYDLVRQINRKTP

RAP1B

156

P61224
NPFIYSLRNKEVISV

OR5K2

286

Q8NHB8
YNVKQLFRRVAAALP

RAB6A

161

P20340
YNVKQLFRRVASALP

RAB6B

161

Q9NRW1
YNVKQLFRRVAAALP

RAB6C

161

Q9H0N0
YNVKQLFRRVAAALP

RAB6D

161

Q53S08
NYIPTQQDVLRTRVK

GNAI1

166

P63096
PEFKYRILQILRVQN

TIPARP

486

Q7Z3E1
IDVEKPLNSFQYQRR

MORC1

461

Q86VD1
LFNPVVYTLRNKEVK

OR10G7

281

Q8NGN6
FLSRVPSDVQKVQYA

MCTP2

846

Q6DN12
IVKEYRNQFPEILRR

MAGEE1

521

Q9HCI5
TQQNRKLTDFYPVRR

KMT5A

216

Q9NQR1
PIARSEVFRYSLQKL

NNAT

46

Q16517
VTPQRKVFRSLKYAE

MBTPS1

126

Q14703
NYIPTQQDVLRTRVK

GNAI3

166

P08754
KVTILELFRSPAYRQ

SLC2A1

256

P11166
ESYAVRKNEFPVIVR

LRRK1

181

Q38SD2
ELLRDFPRQKSYFIV

MYO15A

2291

Q9UKN7
VLKVFLSRTAQRIPY

GPR158

506

Q5T848
RRLSQFNKTAVPVRY

ARSJ

521

Q5FYB0
PQAISYLEKTFQVRR

LMLN

121

Q96KR4
RYRTISKIPQITLNF

KCNH2

326

Q12809
ASYLIKPEVQVRQVA

ECPAS

486

Q5VYK3
DLIRFKPSQRQIYLF

MCF2L2

861

Q86YR7
VTPREVQRLYVQVNK

ETNK2

321

Q9NVF9
PVEIRTILFRYFNKV

KIF27

1106

Q86VH2
RVKRQVRSDPQALYF

PCSK6

146

P29122
NPLIYSLRNKEVFRA

OR2M4

286

Q96R27
YIQIFITVFRLPQKE

OR52A1

221

Q9UKL2
TVLQIKVYRDFINIP

PDZD9

101

Q8IXQ8
LRQPYIKRQISFFLE

NEK4

256

P51957
KRYSIPQAIFAQRVL

ONECUT1

306

Q9UBC0
LKRYSIPQAIFAQRV

ONECUT2

346

O95948
SQYFPDSVIVKNIRQ

DNAJC28

176

Q9NX36
QRIQTRPYLFEQVAK

FAM161B

541

Q96MY7
FDKIFVPQVREYLRS

JRKL

266

Q9Y4A0
SIPRVFYVNQRVAKA

POLE

1361

Q07864
VTNLKPATRYVFQIR

EPHA10

516

Q5JZY3
RQTDVRVTKFKAPQY

ODF3

186

Q96PU9
SFRQPKVVRYRVVNL

PAPPA

346

Q13219
VVYTLFVPFRQKTDV

PANX1

291

Q96RD7
RALEFTNIYVKNLPV

PABPC1L

186

Q4VXU2
KAFTEINRLLPYFRQ

MSL2

26

Q9HCI7
RYVLFVLAVLQKSEP

PTPRS

1241

Q13332
LPFYFVQKIERVQNL

PARP12

521

Q9H0J9
RYLLVRTPKTFAEAQ

PRG3

111

Q9Y2Y8
KNYVQRIVDVRPTLV

PIKFYVE

736

Q9Y2I7
PERAIFQIKQYNSVS

ATM

2271

Q13315
QYFERASLIQPTQVK

IFT88

641

Q13099
VQDLKPFTEYVFRIR

IL6ST

286

P40189
IYNIEDRTRVPNKFR

KDM2A

311

Q9Y2K7
VVFFNKRVYNIPVRF

BLNK

386

Q8WV28
KRVYNIPVRFIEATK

BLNK

391

Q8WV28
LRSQEVPEFRNYKQV

CC2D2A

916

Q9P2K1
QAQFYENIVKVIRPK

DOCK1

1321

Q14185
VNEVQRFEYSRPIRK

DOCK1

1431

Q14185
NFERKAVYQRQVRAP

DMRT2

186

Q9Y5R5
AVYQRQVRAPSLLAK

DMRT2

191

Q9Y5R5
VTQNRVFAYLCKRVP

CEP70

191

Q8NHQ1
RFNVLQYVVPEVKDL

EIF3A

376

Q14152
LDTFVYQIPRRIFIQ

EFCAB6

326

Q5THR3
RIKPSAFYARPQQTI

DCDC2B

256

A2VCK2
VLREQIVAQYPSLKR

FAM111A

291

Q96PZ2
PVFVRFIRSYKEAEQ

FMNL3

916

Q8IVF7
RPLQFASQKEVVLYA

CTU1

211

Q7Z7A3
SKVPDEVRQRYINLF

LINC00032

36

P0C843
SPRYVDRVTEFLQQK

CDK5RAP3

426

Q96JB5
FIQTDKPVYRPQHRV

CPAMD8

131

Q8IZJ3
EALVKVINNPSYRQR

UGT8

411

Q16880
PYAIREVNINKFCRI

FHOD3

1231

Q2V2M9
PAKAKYVFRDVVQIT

C1S

306

P09871
VLPQSIYRRKLQHFQ

CCDC152

206

Q4G0S7
RLVQPFEDNIKISVY

ADGRF2

161

Q8IZF7
IQESKLPVYQVFARE

ANK3

2751

Q12955
VFEYRTQNVARLPII

COL5A2

1461

P05997
YKVFTQRVPDKRVII

GPR156

146

Q8NFN8
AFQQYPDLLKSIIRV

DDX53

226

Q86TM3
IKRLQVAQLYPIAIF

DLG2

781

Q15700
VNPIIYTTFNIEFRK

DRD2

421

P14416
NNFIPPIVARYVRVV

DCBLD1

381

Q8N8Z6
KLYRQNIVLNRPFSI

FAM217A

471

Q8IXS0
LERQPVTKNTFRQYR

GRK5

176

P34947
LERQPVTKNTFRQYR

GRK6

176

P43250
YIIIAKPERNVRSAF

GRM1

836

Q13255
FKIQLVAVNYIPEVR

DCTN4

296

Q9UJW0
NTYLTKAFQQRDPRI

DNAH10

4061

Q8IVF4
SPFINENTRRKFLIY

SEC14L5

436

O43304
ITRQYRKVKAPAAAQ

PRDM2

1696

Q13029
KNRVLQIIPYEFNRV

PTPRA

561

P18433
NPFIYTLRNKEVRET

OR6F1

286

Q8NGZ6
NPIVYAVRTKQIRES

OR52M1

291

Q8NGK5
NRVTPQNERIYLIVK

KIF13A

1241

Q9H1H9
KRNTLNPVYNEAIVF

SYT9

411

Q86SS6
QLPFLLYQVTRKFRD

PARS2

176

Q7L3T8
KVLDIIYQPQAIFRV

NLE1

86

Q9NVX2
IYQPQAIFRVRAVTR

NLE1

91

Q9NVX2
VNQLKPFHRYEIRIQ

USH2A

4596

O75445
LKRIPQAVIDEFYSR

ATP6V1B1

486

P15313
PKFIVDYQTQERERI

TBC1D31

681

Q96DN5
VQYLVLRKDLSQAPF

PTRHD1

26

Q6GMV3
IYKVPQVRVLDFQKV

SNRPA1

136

P09661
IDTPQFQRLRYIKQL

SAMHD1

136

Q9Y3Z3
IQVRFKNLASRPYSL

F5

1656

P12259
ITYNRFQAVTRPIKT

PTAFR

111

P25105
EVQRKEVQARAVFYP

PHF12

786

Q96QT6
RKIYSINEDLVFLRP

PREX1

666

Q8TCU6
DVKVARTLPVAQAYQ

TANC2

1946

Q9HCD6
RNQQSDFYKIPIEIV

STEAP2

241

Q8NFT2
QQIPVFRQKRSDLYA

NIT2

256

Q9NQR4
VVAKYINRFRQAQPT

PROSER3

101

Q2NL68
EYEPAKRFSIRQIRQ

STK11

291

Q15831
RAFKELPVNAQNYVR

ADSS2

416

P30520
RRIIFYSLIKPSINE

SUPV3L1

436

Q8IYB8
FKLSPRVKRIFYQNV

IL9R

291

Q01113
VAVYRAQPVVKASVQ

ITGA2B

476

P08514
DAAVIPIKNNRFYTI

PIP

126

P12273
YILFVRKNAIVVLIP

DIS3

851

Q9Y2L1
TIPFIIRYRKELINN

SRBD1

241

Q8N5C6
SIAYKATVNARPQRV

RPTOR

836

Q8N122
KSTIVRLLFRFYEPQ

ABCB7

511

O75027
RVQILKDYVRQHFPA

ACLY

986

P53396
QPSIAKRYIDQKFVQ

PPP2R5A

176

Q15172
AYRCIRVNKFQRVDP

BTG3

56

Q14201
IIDQRTRQPVQTKFY

BCO1

286

Q9HAY6
ITQKILRDFYRPFNA

CHST15

531

Q7LFX5
LQQTVRKRNFPFYIT

ERVK-25

546

P63136
YVRLKPALQRLDFSV

RETREG3

216

Q86VR2
KTLPIYAEVQRAVLF

RNF212

251

Q495C1
EIFYDLVRQINRKTP

nan

156

A6NIZ1
TRIYLDLPQNFKIFV

RNF14

36

Q9UBS8
RQSFYRNPIKEVVRF

TPTE

256

P56180
VPEKNFRVTAYKAVQ

THRAP3

516

Q9Y2W1
IYQKLTFREVVSPQE

NCAM2

111

O15394
TLYNRIKREPNKFFV

PYGM

586

P11217
FAVIRRASLEKNPYQ

TSPAN32

41

Q96QS1
SIYQRDPLKLVATFR

STAT6

86

P42226
EKPTQIYRFLRTRNL

SUZ12

91

Q15022
ITERANPYFILQRRK

TBC1D9

16

Q6ZT07
SPRYKIIEKRQSVAF

TRBV11-2

26

A0A584
PNFYDTISKIRLRQQ

SMIM19

66

Q96E16
SENVVVRVPQYFKDL

PHEX

336

P78562
VYRADAKEIPRIFQI

ROCK2

1216

O75116
QRIKEILPQYVSAFA

SLFN12

216

Q8IYM2
NPQYLVEKIIRTRIY

PRPF38A

16

Q8NAV1
VQTKFPAYERVVLRE

TJP1

626

Q07157
RRPRSQQYSVLFKQL

ZNF879

181

B4DU55
AIPAAQVILNKYVER

TTC37

961

Q6PGP7
LQQTVRKRNFPFYIT

ERVK-19

551

Q9WJR5
TVIDQVKRFQEIPIY

VWA3B

616

Q502W6
VKRFQEIPIYTISFN

VWA3B

621

Q502W6
QLRFNKPVRYAATVI

SLC5A12

116

Q1EHB4
KEQQKRYFPVFSDRV

SLFN5

371

Q08AF3
VQVLFSIPDFQRKYV

USP5

341

P45974
PLRVLRYVEVFKNSD

TRPV5

641

Q9NQA5
SILNNPIVKARYERF

ZNF326

451

Q5BKZ1
KFVRFQELAVQAPRA

LGI3

501

Q8N145