Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmRNA binding

CASC3 FXR1 G3BP1 ATXN2 SUPT5H RBMX NCL TAF15 DHX33 MBD2 MECP2 CHTOP METTL14

1.36e-086945113GO:0003729
GeneOntologyMolecularFunctionmolecular condensate scaffold activity

FXR1 G3BP1 MECP2 NUP153

3.93e-0642514GO:0140693
GeneOntologyMolecularFunctionmethyl-CpG binding

MBD2 MECP2 CHTOP

6.71e-0531513GO:0008327
GeneOntologyMolecularFunctionPH domain binding

LSM4 NCL

2.28e-049512GO:0042731
GeneOntologyMolecularFunctionsiRNA binding

MBD2 MECP2

4.15e-0412512GO:0035197
GeneOntologyMolecularFunctionchromatin binding

RBMXL1 SUPT5H RBMX MBD6 MBD2 MECP2 NUP153 RING1

5.27e-04739518GO:0003682
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

G3BP1 FBL DHX57 DHX33 METTL14 LRRC47

6.51e-04417516GO:0140098
GeneOntologyMolecularFunctionRNA helicase activity

G3BP1 DHX57 DHX33

1.04e-0378513GO:0003724
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

G3BP1 DHX57 DHX33

1.12e-0380513GO:0008186
GeneOntologyBiologicalProcessRNA localization

CASC3 FXR1 ATXN2 FBL CHTOP NUP153

1.37e-05217506GO:0006403
GeneOntologyBiologicalProcessRNA transport

CASC3 FXR1 ATXN2 CHTOP NUP153

6.46e-05175505GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

CASC3 FXR1 ATXN2 CHTOP NUP153

6.46e-05175505GO:0050657
GeneOntologyBiologicalProcessestablishment of RNA localization

CASC3 FXR1 ATXN2 CHTOP NUP153

7.00e-05178505GO:0051236
GeneOntologyBiologicalProcessretrograde neuronal dense core vesicle transport

MECP2 KIF1C

8.59e-056502GO:1990049
GeneOntologyBiologicalProcessregulation of mRNA metabolic process

CASC3 FXR1 RBMXL1 RBMX NCL TAF15 METTL14

9.05e-05443507GO:1903311
GeneOntologyBiologicalProcessanterograde neuronal dense core vesicle transport

MECP2 KIF1C

1.60e-048502GO:1990048
GeneOntologyBiologicalProcesspositive regulation of mRNA splicing, via spliceosome

RBMXL1 RBMX NCL

1.66e-0444503GO:0048026
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

FXR1 RBMX TAF15 METTL14

1.73e-04115504GO:1903312
GeneOntologyBiologicalProcessRNA splicing

CASC3 RBMXL1 RBMX LSM4 NCL TAF15 METTL14

1.96e-04502507GO:0008380
GeneOntologyBiologicalProcessmRNA splicing, via spliceosome

CASC3 RBMXL1 RBMX LSM4 NCL METTL14

2.19e-04358506GO:0000398
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions with bulged adenosine as nucleophile

CASC3 RBMXL1 RBMX LSM4 NCL METTL14

2.19e-04358506GO:0000377
GeneOntologyBiologicalProcesspositive regulation of mRNA processing

RBMXL1 RBMX NCL

2.28e-0449503GO:0050685
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions

CASC3 RBMXL1 RBMX LSM4 NCL METTL14

2.32e-04362506GO:0000375
GeneOntologyBiologicalProcessnuclear pore complex assembly

FXR1 NUP153

3.12e-0411502GO:0051292
GeneOntologyBiologicalProcessnucleobase-containing compound transport

CASC3 FXR1 ATXN2 CHTOP NUP153

3.35e-04249505GO:0015931
GeneOntologyBiologicalProcessdense core granule cytoskeletal transport

MECP2 KIF1C

3.74e-0412502GO:0099519
GeneOntologyBiologicalProcesspositive regulation of mRNA metabolic process

FXR1 RBMXL1 RBMX NCL METTL14

4.01e-04259505GO:1903313
GeneOntologyBiologicalProcessmRNA transport

CASC3 FXR1 CHTOP NUP153

4.20e-04145504GO:0051028
GeneOntologyBiologicalProcesspositive regulation of RNA splicing

RBMXL1 RBMX NCL

4.80e-0463503GO:0033120
GeneOntologyBiologicalProcessdense core granule transport

MECP2 KIF1C

5.14e-0414502GO:1901950
GeneOntologyBiologicalProcessnuclear pore organization

FXR1 NUP153

8.60e-0418502GO:0006999
GeneOntologyBiologicalProcessnuclear export

CASC3 NOP9 CHTOP NUP153

1.05e-03185504GO:0051168
GeneOntologyCellularComponentnuclear protein-containing complex

CASC3 RBMXL1 SUPT5H RBMX LSM4 E2F3 NCL MBD2 CCDC9 CHTOP NUP153 CREBZF RING1

1.87e-0513775113GO:0140513
GeneOntologyCellularComponentsupraspliceosomal complex

RBMXL1 RBMX

3.49e-054512GO:0044530
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

CASC3 FXR1 G3BP1 ATXN2 LSM4 NCL

4.76e-05269516GO:0036464
GeneOntologyCellularComponentribonucleoprotein granule

CASC3 FXR1 G3BP1 ATXN2 LSM4 NCL

6.81e-05287516GO:0035770
GeneOntologyCellularComponentcytoplasmic stress granule

CASC3 FXR1 G3BP1 ATXN2

8.85e-0596514GO:0010494
GeneOntologyCellularComponentdense fibrillar component

FBL NCL

1.22e-047512GO:0001651
GeneOntologyCellularComponentspliceosomal complex

CASC3 RBMXL1 RBMX LSM4 NCL

1.76e-04215515GO:0005681
GeneOntologyCellularComponentribonucleoprotein complex

CASC3 NOP9 ILF2 G3BP1 RBMXL1 ATXN2 FBL RBMX LSM4 NCL

5.32e-0411945110GO:1990904
GeneOntologyCellularComponentexon-exon junction complex

CASC3 CCDC9

1.19e-0321512GO:0035145
GeneOntologyCellularComponentheterochromatin

MBD2 MECP2 RING1

1.93e-03101513GO:0000792
HumanPhenoAbnormal superficial reflex

ATXN2 TSPOAP1 DDHD1 TAF15 MECP2 KIF1C

8.12e-05301146HP:0031828
HumanPhenoBabinski sign

ATXN2 TSPOAP1 DDHD1 TAF15 MECP2 KIF1C

8.12e-05301146HP:0003487
HumanPhenoLower limb hyperreflexia

ZNF142 TSPOAP1 MECP2 KIF1C

8.69e-0592144HP:0002395
HumanPhenoCachexia

ATXN2 EWSR1 TAF15 MECP2

1.20e-04100144HP:0004326
HumanPhenoAbnormal tongue physiology

FXR1 ATXN2 TAF15 MECP2

2.07e-04115144HP:0030810
DomainMethyl_CpG_DNA-bd

MBD6 MBD2 MECP2

2.93e-0611503IPR001739
DomainMBD

MBD6 MBD2 MECP2

2.93e-0611503PF01429
DomainMBD

MBD6 MBD2 MECP2

2.93e-0611503SM00391
DomainMBD

MBD6 MBD2 MECP2

2.93e-0611503PS50982
DomainDNA-bd_dom

MBD6 MBD2 MECP2

2.93e-0611503IPR016177
DomainRRM_1

G3BP1 RBMXL1 RBMX EWSR1 NCL TAF15

1.87e-05208506PF00076
DomainRRM

G3BP1 RBMXL1 RBMX EWSR1 NCL TAF15

2.38e-05217506SM00360
Domainzf-RanBP

EWSR1 TAF15 NUP153

2.68e-0522503PF00641
DomainRRM_dom

G3BP1 RBMXL1 RBMX EWSR1 NCL TAF15

3.07e-05227506IPR000504
DomainZnF_RBZ

EWSR1 TAF15 NUP153

3.08e-0523503SM00547
DomainRRM_dom_euk

RBMXL1 RBMX NCL

3.08e-0523503IPR003954
DomainRRM_1

RBMXL1 RBMX NCL

3.08e-0523503SM00361
DomainZF_RANBP2_2

EWSR1 TAF15 NUP153

3.08e-0523503PS50199
DomainRRM

G3BP1 RBMXL1 RBMX EWSR1 NCL TAF15

3.30e-05230506PS50102
DomainZF_RANBP2_1

EWSR1 TAF15 NUP153

3.51e-0524503PS01358
DomainZnf_RanBP2

EWSR1 TAF15 NUP153

3.98e-0525503IPR001876
Domain-

G3BP1 RBMXL1 RBMX EWSR1 NCL TAF15

4.59e-052445063.30.70.330
DomainNucleotide-bd_a/b_plait

G3BP1 RBMXL1 RBMX EWSR1 NCL TAF15

6.26e-05258506IPR012677
DomainHMGI/Y_DNA-bd_CS

EWSR1 MBD2 MECP2

7.70e-0531503IPR000637
DomainRBM1CTR

RBMXL1 RBMX

1.95e-048502PF08081
DomainRBM1CTR

RBMXL1 RBMX

1.95e-048502IPR012604
Domain-

MBD2 MECP2

1.95e-0485023.30.890.10
Domain-

EWSR1 TAF15

3.12e-04105024.10.1060.10
DomainDUF1605

DHX57 DHX33

9.31e-0417502IPR011709
DomainOB_NTP_bind

DHX57 DHX33

9.31e-0417502PF07717
DomainHA2

DHX57 DHX33

1.05e-0318502PF04408
DomainHelicase-assoc_dom

DHX57 DHX33

1.05e-0318502IPR007502
DomainHA2

DHX57 DHX33

1.05e-0318502SM00847
DomainLSM_dom

ATXN2 LSM4

1.57e-0322502IPR010920
DomainDNA/RNA_helicase_DEAH_CS

DHX57 DHX33

3.95e-0335502IPR002464
DomainDEAH_ATP_HELICASE

DHX57 DHX33

4.64e-0338502PS00690
PathwayWP_MRNA_PROCESSING

NOP9 FXR1 G3BP1 RBMXL1 FBL SUPT5H RBMX LSM4 EWSR1 NCL TAF15

9.28e-094513611MM15946
PathwayREACTOME_METABOLISM_OF_RNA

CASC3 FBL SUPT5H RBMX LSM4 NCL CHTOP NUP153 METTL14

1.70e-05612369MM15547
PathwayREACTOME_METABOLISM_OF_RNA

CASC3 FBL SUPT5H RBMX LSM4 NCL CHTOP NUP153 METTL14

6.36e-05724369M16843
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

CASC3 RBMX LSM4 CHTOP NUP153 METTL14

6.47e-05277366MM15414
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

CASC3 RBMX LSM4 CHTOP NUP153 METTL14

7.28e-05283366M13087
PathwayBIOCARTA_SARS_PATHWAY

FBL NCL

1.32e-047362M5374
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

CASC3 NOP9 FXR1 ILF2 G3BP1 ATXN2 FBL SUPT5H NOM1 RBMX DHX57 LSM4 EWSR1 NCL TAF15 CCDC9 CHTOP PURG KIF1C LRRC47

1.02e-19807522022681889
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

NOP9 FXR1 ILF2 G3BP1 FBL SUPT5H RBMX DHX57 LSM4 EWSR1 NCL TAF15 MECP2 CCDC9 METTL14 RING1

5.34e-15723521634133714
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

FXR1 ILF2 G3BP1 RBMXL1 FBL RBMX LSM4 EWSR1 NCL TMEM214 TAF15 ERMP1 CHTOP LRRC47 RING1

8.75e-14711521533022573
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

NOP9 ILF2 FBL SUPT5H NOM1 RBMX LSM4 EWSR1 NCL TMEM214 TAF15 DHX33 MBD2 MECP2 CHTOP NUP153 RING1

2.90e-121294521730804502
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

CASC3 FXR1 ILF2 G3BP1 ATXN2 FBL NOM1 RBMX DHX57 EWSR1 NCL TAF15 MBD2 MECP2 CHTOP LRRC47 RING1

7.22e-121371521736244648
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

CASC3 ZNF469 NOP9 FXR1 ILF2 G3BP1 SUPT5H RBMX DHX57 EWSR1 TAF15 CCDC9 CHTOP

1.04e-11653521333742100
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

IRS4 FXR1 ILF2 G3BP1 FBL SUPT5H RBMX DHX57 EWSR1 NCL TAF15 NUP153 LRRC47

1.04e-11653521322586326
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

IRS4 FXR1 ILF2 G3BP1 ATXN2 RBMX EWSR1 NCL TAF15 TUSC1 CCDC9 CHTOP

2.58e-11551521234728620
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

CASC3 FXR1 ILF2 G3BP1 RBMXL1 ATXN2 FBL RBMX DHX57 LSM4 NCL TAF15 CHTOP

3.09e-11713521329802200
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

IRS4 FXR1 ILF2 G3BP1 FBL RBMX NCL TAF15 MECP2 NUP153 LRRC47

4.56e-11441521131239290
Pubmed

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.

FXR1 ILF2 G3BP1 FBL SUPT5H LSM4 TAF15 MBD2

5.40e-1114752828977470
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

CASC3 FXR1 ILF2 G3BP1 RBMXL1 ATXN2 RBMX DHX57 EWSR1 NCL PURG

7.47e-11462521131138677
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

FXR1 ILF2 G3BP1 ATXN2 FBL SUPT5H RBMX DHX57 EWSR1 NCL TAF15 CHTOP

9.11e-11615521231048545
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

CASC3 G3BP1 ATXN2 FBL SUPT5H DHX57 DHX33 MECP2 NUP153 RING1

9.91e-11349521025665578
Pubmed

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.

FXR1 ILF2 G3BP1 FBL RBMX LSM4 EWSR1 NCL NUP153

1.76e-1026052936199071
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

FXR1 ILF2 G3BP1 RBMXL1 ATXN2 FBL NOM1 RBMX EWSR1 NCL MECP2 CHTOP NUP153 METTL14 LRRC47

2.76e-101257521536526897
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

NOP9 IRS4 FXR1 ILF2 ATXN2 FBL NOM1 RBMX DHX57 EWSR1 NCL TAF15

2.77e-10678521230209976
Pubmed

Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.

FXR1 ILF2 G3BP1 FBL RBMX DHX57 EWSR1

6.08e-1012152734029587
Pubmed

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.

ILF2 G3BP1 FBL RBMX EWSR1 NCL TAF15 MECP2 CHTOP LRRC47

7.49e-10430521038172120
Pubmed

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

FXR1 G3BP1 RBMX EWSR1 TAF15

8.49e-103052515782174
Pubmed

SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation.

FXR1 ILF2 G3BP1 RBMXL1 EWSR1 NCL NUP153

1.01e-0913052732905556
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

FXR1 ILF2 G3BP1 FBL NOM1 RBMX DHX57 NCL CHTOP KIF1C LRRC47

1.19e-09601521133658012
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

ILF2 G3BP1 FBL SUPT5H NOM1 RBMX EWSR1 NCL TAF15 MBD2 CHTOP

1.28e-09605521128977666
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

IRS4 ILF2 G3BP1 FBL RBMX EWSR1 NCL TAF15 CHTOP NUP153 LRRC47

2.33e-09641521136057605
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

IRS4 FXR1 ILF2 G3BP1 NOM1 DHX57 EWSR1 NCL DHX33 LRRC47

2.42e-09486521030940648
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

NOP9 IRS4 FXR1 ILF2 G3BP1 FBL SUPT5H RBMX EWSR1 NCL TAF15 CHTOP NUP153

2.54e-091024521324711643
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

IRS4 FXR1 ILF2 G3BP1 RBMXL1 FBL NOM1 RBMX LSM4 EWSR1 NCL TAF15 DHX33 LRRC47

2.96e-091257521437317656
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

NOP9 IRS4 FXR1 G3BP1 NCL TAF15 DHX33 LRRC47

3.12e-0924552835652658
Pubmed

Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.

RBMXL1 FBL RBMX EWSR1 NCL TAF15 NUP153

3.15e-0915352728225217
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

NOP9 FXR1 ILF2 G3BP1 FBL NOM1 RBMX EWSR1 NCL TAF15 CHTOP NUP153

3.40e-09847521235850772
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

FXR1 G3BP1 ATXN2 RBMX EWSR1 CCDC9 KIF1C LRRC47

4.67e-0925852837794589
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

IRS4 FXR1 ILF2 G3BP1 FBL SUPT5H NOM1 RBMX DHX57 LSM4 EWSR1 NCL CHTOP RING1

6.36e-091335521429229926
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

ILF2 G3BP1 RBMXL1 FBL RBMX DHX57 LSM4 EWSR1 NCL TAF15 RRAS CHTOP NUP153

1.04e-081153521329845934
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

NOP9 FXR1 ILF2 G3BP1 FBL NOM1 RBMX DHX57 NCL DHX33 CHTOP

1.33e-08759521135915203
Pubmed

Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.

CASC3 FXR1 ILF2 G3BP1 RBMX

1.51e-085252526265008
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

IRS4 FXR1 ILF2 G3BP1 ATXN2 FBL RBMX DHX57 LSM4 NCL NUP153 LRRC47

1.55e-08971521233306668
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

FXR1 G3BP1 FBL NOM1 EWSR1 NCL TAF15 MBD2 CHTOP NUP153

4.07e-08655521035819319
Pubmed

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.

FXR1 ILF2 G3BP1 DHX57 EWSR1 NCL LRRC47

4.25e-0822352733731348
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

FXR1 G3BP1 RBMXL1 RBMX LSM4 EWSR1 NCL TAF15

4.65e-0834752816033648
Pubmed

Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.

IRS4 ILF2 FBL RBMX EWSR1 NCL CHTOP

6.25e-0823652736339263
Pubmed

The SARS-CoV-2 RNA interactome.

FXR1 ILF2 G3BP1 EWSR1 LRRC47

9.14e-087452533989516
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

IRS4 ILF2 G3BP1 RBMXL1 FBL RBMX LSM4 EWSR1 NCL CHTOP

1.13e-07731521029298432
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

FXR1 ILF2 G3BP1 RBMXL1 FBL NOM1 RBMX EWSR1 NCL DHX33 LRRC47

1.28e-07949521136574265
Pubmed

ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.

IRS4 G3BP1 NFATC4 NCL TAF15 LRRC47

1.83e-0716652635687106
Pubmed

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.

CASC3 ILF2 FBL RBMX CCDC9 CHTOP

2.04e-0716952623084401
Pubmed

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

FXR1 ILF2 RBMXL1 FBL RBMX EWSR1 NCL TAF15

2.04e-0742152834650049
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

CASC3 IRS4 FXR1 ILF2 RBMXL1 ATXN2 FBL NOM1 RBMX DHX57 NCL TMEM214 ARMCX2

2.17e-071496521332877691
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CASC3 ATXN2 NOM1 DHX57 TMEM214 TAF15 ERMP1 DHX33 RRAS MBD2 MECP2 CHTOP METTL14

2.19e-071497521331527615
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

FXR1 ILF2 G3BP1 FBL RBMX EWSR1 NCL TAF15 CCDC9 CHTOP LRRC47 RING1

2.34e-071247521227684187
Pubmed

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3.

FXR1 ILF2 G3BP1 RBMX EWSR1 NCL

2.42e-0717452635031058
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

IRS4 ILF2 G3BP1 ATXN2 RBMX EWSR1 NCL TAF15 CHTOP NUP153

2.87e-07809521032129710
Pubmed

Revealing A-Raf functions through its interactome.

IRS4 ILF2 FBL EWSR1 NCL TAF15

3.70e-0718752629777862
Pubmed

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.

IRS4 FXR1 ILF2 G3BP1 FBL RBMX PAK4 NCL

4.18e-0746352834901782
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

ZNF142 ILF2 G3BP1 RBMXL1 FBL NOM1 RBMX EWSR1 NCL TAF15

4.23e-07844521025963833
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

NOP9 ILF2 RBMXL1 SUPT5H RBMX DHX57 EWSR1 NCL TAF15 GPC2 MECP2

4.72e-071082521138697112
Pubmed

In vitro nuclear interactome of the HIV-1 Tat protein.

ILF2 FBL NCL TAF15 MBD2 NUP153

4.72e-0719552619454010
Pubmed

Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.

ILF2 FBL RBMX EWSR1 NCL TAF15

6.33e-0720552627976729
Pubmed

UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.

IRS4 ILF2 RBMXL1 FBL PAK4 LSM4 TAF15 CHTOP

6.51e-0749152836273042
Pubmed

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.

IRS4 ILF2 G3BP1 NOM1 RBMX EWSR1 NCL TAF15 RING1

9.17e-0770452932994395
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

NOP9 IRS4 FXR1 ILF2 G3BP1 FBL SUPT5H RBMX NCL CHTOP NUP153 LRRC47

9.64e-071425521230948266
Pubmed

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

ILF2 G3BP1 FBL RBMX DHX57 NCL

1.03e-0622352620020773
Pubmed

Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL.

ILF2 FBL RBMX NCL MBD2

1.16e-0612352535583604
Pubmed

Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.

IRS4 FXR1 ILF2 G3BP1 ATXN2 RBMX EWSR1 NCL TAF15

1.17e-0672552927025967
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

FBL NOM1 DHX57 TMEM214 MECP2 CHTOP METTL14 RING1

1.20e-0653352830554943
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

IRS4 ILF2 G3BP1 ATXN2 RBMX EWSR1 NCL TAF15 MECP2 NUP153

1.28e-06954521036373674
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CASC3 FXR1 ILF2 G3BP1 ATXN2 ADGRB2 EWSR1 NCL TAF15 NUP153

1.39e-06963521028671696
Pubmed

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

FXR1 ILF2 FBL NCL

1.65e-065752417932509
Pubmed

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.

FXR1 ILF2 FBL RBMX NCL CHTOP

1.74e-0624452630349055
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

ILF2 FBL SUPT5H RBMX EWSR1 NCL TAF15 DHX33 MBD2 NUP153

1.77e-06989521036424410
Pubmed

Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.

ILF2 G3BP1 RBMX EWSR1 NCL NUP153

1.78e-0624552621182205
Pubmed

Landscape of the SOX2 protein-protein interactome.

ILF2 G3BP1 EWSR1 NCL TAF15

1.90e-0613652521280222
Pubmed

Interactome analysis of the human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (hMTr1) protein.

FXR1 ILF2 G3BP1 RBMX NCL

2.05e-0613852530320910
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

G3BP1 ATXN2 SUPT5H LSM4 EWSR1 NCL TAF15

2.13e-0639952735987950
Pubmed

Localization of fibrillarin and nucleolin in nucleoli of mouse preimplantation embryos.

FBL NCL

2.19e-0625227772340
Pubmed

MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation.

NCL MECP2

2.19e-06252221420494
Pubmed

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome.

MBD2 MECP2

2.19e-06252211242117
Pubmed

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

EWSR1 TAF15

2.19e-06252222454397
Pubmed

Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin.

FBL NCL

2.19e-06252222909121
Pubmed

Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation.

MBD2 MECP2

2.19e-06252215939760
Pubmed

Components of the DNA methylation system of chromatin control are RNA-binding proteins.

MBD2 MECP2

2.19e-06252215342650
Pubmed

Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.

MBD2 MECP2

2.19e-06252214633992
Pubmed

Direct homo- and hetero-interactions of MeCP2 and MBD2.

MBD2 MECP2

2.19e-06252223335972
Pubmed

Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins.

EWSR1 TAF15

2.19e-0625228954779
Pubmed

METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.

MN1 METTL14

2.19e-06252235810559
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

IRS4 NFATC4 FBL NOM1 RBMX CHTOP LRRC47 RING1

2.34e-0658352829844126
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

FXR1 NCL TMEM214 TAF15 ERMP1 DHX33 MBD2 GPR162 KIF1C RING1

2.35e-061021521026760575
Pubmed

rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.

ILF2 SUPT5H DHX33 KIF1C RING1

2.35e-0614252530217970
Pubmed

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

ILF2 RBMX MECP2 CHTOP

2.99e-066652432051553
Pubmed

Repression of rRNA transcription by PARIS contributes to Parkinson's disease.

IRS4 ILF2 FBL RBMX NCL LRRC47

3.26e-0627252625315684
Pubmed

TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.

ILF2 RBMX TMEM214 TAF15 MECP2

3.29e-0615252528192407
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

FXR1 ILF2 G3BP1 FBL RBMX NCL MECP2 CHTOP

3.95e-0662652833644029
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

IRS4 FXR1 G3BP1 FBL SUPT5H NCL NUP153

4.05e-0644052734244565
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

SUPT5H EWSR1 NCL TAF15 MECP2 NUP153

4.09e-0628352630585729
Pubmed

Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 Virus.

G3BP1 ATXN2 FBL NOM1 DHX57

4.10e-0615952534578187
Pubmed

Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.

ILF2 RBMX EWSR1 NCL MECP2

4.10e-0615952522751105
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

FXR1 ILF2 G3BP1 FBL RBMX DHX57 NCL DHX33 CHTOP LRRC47 RING1

4.13e-061353521129467282
Pubmed

A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.

ILF2 G3BP1 RBMXL1 LSM4 EWSR1 NCL

4.35e-0628652632041737
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

IRS4 FXR1 ILF2 G3BP1 FBL RBMX NUP153 LRRC47

4.54e-0663852833239621
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

ILF2 G3BP1 RBMXL1 FBL RBMX NCL TAF15 CHTOP

5.32e-0665252831180492
Pubmed

Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.

FXR1 G3BP1 LSM4

5.47e-062352320696395
InteractionELAVL2 interactions

CASC3 FXR1 ILF2 G3BP1 RBMXL1 ATXN2 RBMX MECP2 CCDC9 PURG

3.60e-111885110int:ELAVL2
InteractionPRMT1 interactions

IRS4 FXR1 ILF2 G3BP1 ATXN2 FBL SUPT5H RBMX EWSR1 NCL TAF15 MBD2 TUSC1 MECP2 CCDC9 CHTOP METTL14

5.58e-119295117int:PRMT1
InteractionSNRNP70 interactions

CASC3 FXR1 ILF2 G3BP1 RBMXL1 ATXN2 FBL RBMX DHX57 LSM4 EWSR1 NCL TAF15 MECP2 CCDC9 CHTOP METTL14

1.36e-109845117int:SNRNP70
InteractionMYCN interactions

CASC3 IRS4 FXR1 ILF2 G3BP1 RBMXL1 ATXN2 FBL NOM1 RBMX DHX57 LSM4 EWSR1 NCL TAF15 MECP2 CCDC9 CHTOP RING1

3.57e-1013735119int:MYCN
InteractionDDX5 interactions

FXR1 ILF2 G3BP1 ATXN2 FBL SUPT5H RBMX EWSR1 NCL TAF15 MBD6 MECP2 METTL14

1.10e-095685113int:DDX5
InteractionWDR77 interactions

FXR1 ILF2 G3BP1 FBL SUPT5H LSM4 NCL TAF15 MBD2 CHTOP METTL14

1.31e-093615111int:WDR77
InteractionRBM8A interactions

CASC3 NOP9 ILF2 ATXN2 SUPT5H RBMX DHX57 EWSR1 NCL MECP2 CCDC9 CHTOP

1.68e-094735112int:RBM8A
InteractionILF2 interactions

CASC3 FXR1 ILF2 RBMXL1 ATXN2 SUPT5H RBMX EWSR1 NCL TAF15 MECP2 METTL14 KIF1C

1.75e-095905113int:ILF2
InteractionTDRD3 interactions

CASC3 FXR1 G3BP1 ATXN2 FBL DHX57 LSM4 EWSR1 CCDC9

2.76e-09212519int:TDRD3
InteractionSRSF3 interactions

CASC3 ILF2 G3BP1 RBMXL1 RBMX EWSR1 NCL TAF15 MBD6 MECP2 CCDC9 METTL14

5.09e-095225112int:SRSF3
InteractionBMI1 interactions

CASC3 FXR1 ILF2 G3BP1 ATXN2 FBL PAK4 EWSR1 NCL TAF15 MBD2 CHTOP RING1

6.59e-096595113int:BMI1
InteractionWDR5 interactions

FXR1 ILF2 G3BP1 RBMXL1 FBL RBMX LSM4 EWSR1 NCL TMEM214 TAF15 ERMP1 MBD6 CHTOP LRRC47 RING1

6.62e-0911015116int:WDR5
InteractionDDX17 interactions

ILF2 ATXN2 FBL SUPT5H RBMX EWSR1 NCL TAF15 MBD6 MECP2 METTL14

7.37e-094265111int:DDX17
InteractionRC3H2 interactions

NOP9 IRS4 FXR1 ILF2 G3BP1 ATXN2 FBL NOM1 RBMX DHX57 EWSR1 NCL TAF15

7.61e-096675113int:RC3H2
InteractionSRSF1 interactions

CASC3 FXR1 ILF2 RBMXL1 RBMX DHX57 EWSR1 NCL TAF15 MBD6 MECP2 METTL14

1.36e-085705112int:SRSF1
InteractionSNRPD1 interactions

ILF2 G3BP1 SUPT5H RBMX LSM4 EWSR1 NCL TAF15 MECP2 METTL14

1.37e-083475110int:SNRPD1
InteractionFAM120A interactions

CASC3 FXR1 ILF2 G3BP1 RBMXL1 ATXN2 FBL RBMX TAF15 PURG

1.45e-083495110int:FAM120A
InteractionDDX21 interactions

CASC3 ILF2 G3BP1 FBL RBMX DHX57 NCL TAF15 MECP2 CHTOP NUP153 PURG METTL14

1.83e-087185113int:DDX21
InteractionSYNCRIP interactions

ILF2 G3BP1 RBMXL1 ATXN2 FBL DHX57 LSM4 EWSR1 NCL TAF15 MECP2 PURG METTL14

1.92e-087215113int:SYNCRIP
InteractionRPS16 interactions

CASC3 NOP9 FXR1 ILF2 ATXN2 FBL DHX57 NCL MBD6 MECP2 PURG METTL14 LRRC47

2.01e-087245113int:RPS16
InteractionZC3H18 interactions

IRS4 ILF2 G3BP1 RBMXL1 FBL SUPT5H RBMX LSM4 EWSR1 NCL TAF15 MECP2 CHTOP PURG

2.27e-088775114int:ZC3H18
InteractionSIRT7 interactions

IRS4 FXR1 ILF2 G3BP1 FBL SUPT5H RBMX DHX57 EWSR1 NCL TAF15 NUP153 LRRC47

2.78e-087445113int:SIRT7
InteractionKHDRBS2 interactions

ILF2 ATXN2 SUPT5H RBMX EWSR1 MECP2 CHTOP

3.42e-08129517int:KHDRBS2
InteractionRPS8 interactions

NOP9 ILF2 G3BP1 ATXN2 FBL NOM1 DHX57 NCL MBD6 MECP2 PURG METTL14

5.65e-086495112int:RPS8
InteractionTARDBP interactions

ILF2 G3BP1 ATXN2 FBL RBMX DHX57 EWSR1 NCL TAF15 MECP2 METTL14

5.69e-085205111int:TARDBP
InteractionLARP7 interactions

IRS4 ILF2 G3BP1 RBMXL1 FBL RBMX DHX57 LSM4 EWSR1 NCL TAF15 RRAS CHTOP NUP153 PURG

6.02e-0811135115int:LARP7
InteractionCPSF6 interactions

FXR1 ILF2 G3BP1 SUPT5H RBMX LSM4 EWSR1 TAF15 MECP2 CHTOP METTL14

6.39e-085265111int:CPSF6
InteractionCASC3 interactions

CASC3 ILF2 ATXN2 EWSR1 CCDC9 PURG KIF1C

6.64e-08142517int:CASC3
InteractionHNRNPR interactions

ILF2 ATXN2 FBL RBMX LSM4 EWSR1 NCL TAF15 MBD6 MECP2 METTL14

7.73e-085365111int:HNRNPR
InteractionSRSF7 interactions

CASC3 FXR1 ILF2 RBMXL1 EWSR1 TAF15 MECP2 CCDC9 METTL14 KIF1C

9.24e-084255110int:SRSF7
InteractionKHDRBS3 interactions

FXR1 G3BP1 ATXN2 RBMX MECP2 METTL14

1.33e-0794516int:KHDRBS3
InteractionMEPCE interactions

ILF2 G3BP1 RBMXL1 FBL RBMX DHX57 LSM4 EWSR1 NCL TAF15 RRAS MECP2 CHTOP

1.48e-078595113int:MEPCE
InteractionYTHDF3 interactions

FXR1 G3BP1 ATXN2 FBL DHX57 METTL14 KIF1C LRRC47

1.78e-07246518int:YTHDF3
InteractionRPS6 interactions

NOP9 FXR1 ILF2 G3BP1 ATXN2 FBL NOM1 DHX57 NCL DHX33 MECP2 PURG METTL14

1.81e-078745113int:RPS6
InteractionEP300 interactions

CASC3 ZNF469 NOP9 FXR1 ILF2 G3BP1 SUPT5H RBMX DHX57 EWSR1 TAF15 MN1 MECP2 CCDC9 CHTOP RING1

1.91e-0714015116int:EP300
InteractionHNRNPUL1 interactions

FXR1 ILF2 G3BP1 RBMX EWSR1 NCL TAF15 MECP2 METTL14

2.13e-07351519int:HNRNPUL1
InteractionRALY interactions

CASC3 ILF2 RBMXL1 FBL RBMX TAF15 MECP2 PURG METTL14

2.40e-07356519int:RALY
InteractionCIT interactions

NOP9 ZNF142 FXR1 ILF2 G3BP1 RBMXL1 FBL SUPT5H RBMX DHX57 LSM4 NCL TMEM214 TAF15 NUP153 RING1

3.05e-0714505116int:CIT
InteractionMAGOH interactions

CASC3 FXR1 ILF2 FBL RBMX MECP2 CCDC9 CHTOP

3.05e-07264518int:MAGOH
InteractionHNRNPAB interactions

ILF2 G3BP1 ATXN2 RBMX EWSR1 NCL TAF15 MECP2 METTL14

3.39e-07371519int:HNRNPAB
InteractionHNRNPC interactions

CASC3 ILF2 RBMXL1 SUPT5H RBMX TAF15 MBD2 MECP2 CCDC9 PURG METTL14

4.15e-076345111int:HNRNPC
InteractionSRSF6 interactions

CASC3 FXR1 RBMXL1 NOM1 RBMX DHX57 EWSR1 TAF15 MECP2 METTL14

4.38e-075035110int:SRSF6
InteractionCSDE1 interactions

FXR1 G3BP1 ATXN2 FBL SUPT5H DHX57 METTL14 KIF1C

5.31e-07284518int:CSDE1
InteractionDDX3X interactions

FXR1 ILF2 G3BP1 ATXN2 RBMX DHX57 EWSR1 NCL TAF15 MBD6 MECP2

5.40e-076515111int:DDX3X
InteractionPSPC1 interactions

CASC3 FXR1 ILF2 ATXN2 DHX57 EWSR1 NCL TAF15 MECP2 NUP153

5.43e-075155110int:PSPC1
InteractionRPS3A interactions

NOP9 ILF2 G3BP1 ATXN2 FBL DHX57 NCL MBD6 MECP2 PURG METTL14

5.73e-076555111int:RPS3A
InteractionSAFB2 interactions

FXR1 G3BP1 SUPT5H RBMX EWSR1 TAF15 MECP2

5.76e-07195517int:SAFB2
InteractionPRC1 interactions

FXR1 ILF2 G3BP1 RBMXL1 FBL RBMX ADGRB2 NCL TAF15 DHX33 MN1 MECP2 NUP153

6.16e-079735113int:PRC1
InteractionFMR1 interactions

CASC3 FXR1 ILF2 G3BP1 ATXN2 FBL DHX57 EWSR1 NCL CHTOP

7.81e-075365110int:FMR1
InteractionRC3H1 interactions

NOP9 IRS4 FXR1 ILF2 G3BP1 ATXN2 FBL RBMX DHX57 EWSR1 NCL

7.94e-076775111int:RC3H1
InteractionEIF4ENIF1 interactions

NOP9 FXR1 G3BP1 ATXN2 FBL DHX57 LSM4 EWSR1

8.02e-07300518int:EIF4ENIF1
InteractionRPL31 interactions

ILF2 G3BP1 FBL SUPT5H NOM1 RBMX DHX57 EWSR1 NCL DHX33 METTL14

8.29e-076805111int:RPL31
InteractionPNN interactions

CASC3 ILF2 SUPT5H NCL TAF15 MN1 MECP2 CCDC9

8.44e-07302518int:PNN
InteractionRBM45 interactions

FXR1 ILF2 G3BP1 RBMX EWSR1 NCL MECP2

8.60e-07207517int:RBM45
InteractionWWP2 interactions

FXR1 ILF2 G3BP1 ATXN2 FBL SUPT5H RBMX DHX57 EWSR1 NCL TAF15 CHTOP

9.00e-078405112int:WWP2
InteractionTHOC1 interactions

FXR1 SUPT5H PAK4 TAF15 MECP2 CHTOP KIF1C

9.47e-07210517int:THOC1
InteractionHDLBP interactions

FXR1 ILF2 G3BP1 FBL RBMX DHX57 EWSR1 TAF15 CHTOP METTL14 LRRC47 RING1

1.08e-068555112int:HDLBP
InteractionRIOK1 interactions

ILF2 G3BP1 FBL SUPT5H RBMX DHX57 LSM4 NCL CHTOP LRRC47

1.20e-065625110int:RIOK1
InteractionCLK3 interactions

CASC3 RBMXL1 RBMX MECP2 CCDC9 CHTOP PURG

1.29e-06220517int:CLK3
InteractionNOP56 interactions

FXR1 ILF2 FBL SUPT5H NOM1 DHX57 NCL DHX33 MECP2 METTL14

1.36e-065705110int:NOP56
InteractionSNRPC interactions

ILF2 RBMXL1 SUPT5H RBMX LSM4 EWSR1 TAF15 MECP2 CHTOP

1.40e-06440519int:SNRPC
InteractionPURG interactions

CASC3 ZNF142 RBMXL1 ATXN2 DHX57 NCL PURG

1.42e-06223517int:PURG
InteractionSRSF9 interactions

FXR1 G3BP1 RBMX EWSR1 TAF15 MECP2 METTL14

1.46e-06224517int:SRSF9
InteractionTHRAP3 interactions

CASC3 FXR1 SUPT5H RBMX EWSR1 NCL TAF15 MECP2 METTL14

1.48e-06443519int:THRAP3
InteractionUPF1 interactions

CASC3 FXR1 ILF2 G3BP1 ATXN2 FBL RBMX EWSR1 MECP2 PURG

1.62e-065815110int:UPF1
InteractionSRP72 interactions

FXR1 ILF2 ATXN2 FBL DHX57 NCL MECP2 PURG

1.75e-06333518int:SRP72
InteractionTERF2 interactions

IRS4 FBL SUPT5H NCL DHX33 MECP2 SOCS7 RING1

2.05e-06340518int:TERF2
InteractionMYBBP1A interactions

NOP9 ILF2 G3BP1 FBL NOM1 NCL MBD6 MECP2 METTL14

2.13e-06463519int:MYBBP1A
InteractionHEXIM1 interactions

ILF2 G3BP1 RBMXL1 RBMX DHX57 LSM4 EWSR1 NCL TAF15 RRAS MECP2 CHTOP

2.15e-069135112int:HEXIM1
InteractionR3HDM1 interactions

FXR1 G3BP1 ATXN2 FBL EWSR1

2.25e-0684515int:R3HDM1
InteractionLARP4B interactions

CASC3 FXR1 G3BP1 RBMXL1 ATXN2 FBL DHX57

2.31e-06240517int:LARP4B
InteractionPRMT5 interactions

G3BP1 FBL SUPT5H LSM4 EWSR1 NCL MBD2 CHTOP METTL14

2.45e-06471519int:PRMT5
InteractionNCBP1 interactions

ILF2 ATXN2 FBL SUPT5H NCL TAF15 MECP2 METTL14

2.70e-06353518int:NCBP1
InteractionSRPK1 interactions

ILF2 FBL PAK4 EWSR1 NCL TAF15 CHTOP PURG METTL14

2.72e-06477519int:SRPK1
InteractionCHD4 interactions

ILF2 G3BP1 FBL SUPT5H NOM1 RBMX EWSR1 NCL TAF15 MBD2 MECP2 CHTOP

2.85e-069385112int:CHD4
InteractionC9orf72 interactions

IRS4 FXR1 ILF2 G3BP1 RBMXL1 FBL NOM1 RBMX LSM4 EWSR1 NCL TAF15 DHX33 LRRC47

3.23e-0613195114int:C9orf72
InteractionSPOP interactions

FXR1 ILF2 G3BP1 RBMXL1 FBL EWSR1 NCL CHTOP NUP153

3.44e-06491519int:SPOP
InteractionUBE2O interactions

CASC3 NOP9 IRS4 ILF2 RBMXL1 FBL NOM1 PAK4 LSM4 TAF15 CHTOP

3.55e-067905111int:UBE2O
InteractionDDX50 interactions

FXR1 G3BP1 FBL DHX57 NCL MECP2 PURG

3.63e-06257517int:DDX50
InteractionBRD7 interactions

IRS4 FXR1 ILF2 G3BP1 NOM1 DHX57 EWSR1 NCL DHX33 LRRC47

3.68e-066375110int:BRD7
InteractionEIF4A3 interactions

CASC3 ILF2 FBL SUPT5H NOM1 RBMX MECP2 CCDC9 CHTOP

3.93e-06499519int:EIF4A3
InteractionLYAR interactions

ILF2 FBL NOM1 DHX57 NCL ARMCX2 MBD6 MECP2

4.06e-06373518int:LYAR
InteractionDHX15 interactions

FXR1 ILF2 ATXN2 FBL RBMX EWSR1 NCL TAF15 MECP2

4.12e-06502519int:DHX15
InteractionDDX6 interactions

CASC3 FXR1 ILF2 G3BP1 ATXN2 PAK4 LSM4 NCL MECP2

4.19e-06503519int:DDX6
InteractionU2AF2 interactions

CASC3 ILF2 FBL RBMX EWSR1 NCL TAF15 MECP2 CHTOP METTL14

4.46e-066515110int:U2AF2
InteractionSNRPD3 interactions

ILF2 RBMX LSM4 EWSR1 TAF15 MBD6 MECP2 METTL14

4.66e-06380518int:SNRPD3
InteractionMATR3 interactions

ILF2 MCTP1 G3BP1 RBMXL1 FBL RBMX EWSR1 TAF15 MECP2 METTL14

4.71e-066555110int:MATR3
InteractionCCDC8 interactions

NOP9 IRS4 FXR1 ILF2 G3BP1 FBL RBMX EWSR1 NCL CHTOP

4.77e-066565110int:CCDC8
InteractionFZR1 interactions

IRS4 FXR1 ILF2 G3BP1 ATXN2 FBL RBMX DHX57 LSM4 E2F3 NCL NUP153 LRRC47

4.88e-0611725113int:FZR1
InteractionRPLP0 interactions

CASC3 ILF2 G3BP1 ATXN2 NOM1 EWSR1 NCL MECP2 PURG METTL14

5.03e-066605110int:RPLP0
InteractionRPS9 interactions

ILF2 G3BP1 FBL NOM1 DHX57 NCL MECP2 PURG METTL14

5.07e-06515519int:RPS9
InteractionSNRPF interactions

ILF2 G3BP1 SUPT5H LSM4 EWSR1 TAF15 MECP2 CHTOP

5.12e-06385518int:SNRPF
InteractionSNRPB interactions

ILF2 SUPT5H RBMX LSM4 EWSR1 TAF15 MECP2 CHTOP METTL14

5.23e-06517519int:SNRPB
InteractionG3BP2 interactions

IRS4 FXR1 G3BP1 ATXN2 RBMX DHX57 NCL NUP153 METTL14

5.32e-06518519int:G3BP2
InteractionPRRC2A interactions

CASC3 FXR1 G3BP1 ATXN2 FBL RBMX DHX57 EWSR1

5.53e-06389518int:PRRC2A
InteractionCIC interactions

IRS4 NFATC4 FBL SUPT5H NOM1 RBMX EWSR1 CHTOP LRRC47 RING1

5.98e-066735110int:CIC
InteractionAGO1 interactions

FXR1 ILF2 G3BP1 ATXN2 NCL MECP2

6.63e-06183516int:AGO1
InteractionRECQL4 interactions

IRS4 FXR1 ILF2 G3BP1 FBL SUPT5H NOM1 RBMX DHX57 LSM4 EWSR1 NCL CHTOP RING1

7.11e-0614125114int:RECQL4
InteractionUFL1 interactions

IRS4 FXR1 ILF2 G3BP1 FBL RBMX DHX57 EWSR1 NCL MECP2 METTL14 LRRC47

7.51e-0610315112int:UFL1
InteractionRNF113A interactions

FXR1 G3BP1 FBL NOM1 EWSR1 NCL TAF15 MBD2 CHTOP NUP153

7.63e-066925110int:RNF113A
Cytoband17q21.1

CASC3 RAPGEFL1

2.36e-042052217q21.1
Cytoband17p13.2

DHX33 KIF1C

1.80e-035552217p13.2
GeneFamilyZinc fingers CXXC-type|Methyl-CpG binding domain containing

MBD6 MBD2 MECP2

8.23e-07113231025
GeneFamilyRNA binding motif containing

G3BP1 RBMXL1 RBMX EWSR1 NCL TAF15

1.75e-06213326725
GeneFamilyZinc fingers RANBP2-type |RNA binding motif containing

EWSR1 TAF15 NUP153

6.55e-062132389
GeneFamilyDEAH-box helicases

DHX57 DHX33

3.59e-0416322500
CoexpressionHOUNKPE_HOUSEKEEPING_GENES

CASC3 NOP9 ILF2 G3BP1 FBL LSM4 NCL MBD2 MECP2 CHTOP NUP153 RING1

1.61e-0611295212M42508
CoexpressionHOUNKPE_HOUSEKEEPING_GENES

CASC3 NOP9 ILF2 G3BP1 FBL LSM4 NCL MBD2 MECP2 CHTOP NUP153 RING1

2.09e-0611585212MM1338
CoexpressionMUELLER_PLURINET

FBL LSM4 EWSR1 NCL MBD2 NUP153

2.75e-05299526M123
CoexpressionGINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN

ZNF142 TSPOAP1 EWSR1 GPC2 CHTOP

3.21e-05184525M19988
CoexpressionGSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP

ZNF142 ILF2 MSC TMEM214 CHTOP

4.56e-05198525M9534
CoexpressionGSE15139_GMCSF_TREATED_VS_UNTREATED_NEUTROPHILS_DN

G3BP1 RBMXL1 TMEM214 DHX33 CCDC9

4.67e-05199525M7099
CoexpressionGSE3039_CD4_TCELL_VS_ALPHAALPHA_CD8_TCELL_UP

ATXN2 TSPOAP1 DDHD1 TUSC1 SOCS7

4.78e-05200525M6456
CoexpressionGSE20366_CD103_POS_VS_NEG_TREG_KLRG1NEG_DN

ZNF142 TSPOAP1 DHX33 MBD2 CHTOP

4.78e-05200525M4338
CoexpressionDODD_NASOPHARYNGEAL_CARCINOMA_UP

FXR1 ILF2 G3BP1 FBL NOM1 DDHD1 RBMX E2F3 NCL DHX33 CHTOP

8.09e-0514075211M14427
CoexpressionPUJANA_CHEK2_PCC_NETWORK

ILF2 G3BP1 FBL RBMX LSM4 EWSR1 NCL NUP153

1.18e-04761528M11961
CoexpressionFLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP

G3BP1 GUSBP11 E2F3 ARMCX2 CHTOP NUP153 CREBZF

1.24e-04568527M4023
CoexpressionKRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN

NOP9 G3BP1 ATXN2 TSPOAP1 FBL DHX57 EWSR1 NCL DHX33

1.93e-041045529M8525
CoexpressionHEIDENBLAD_AMPLIFIED_IN_PANCREATIC_CANCER

FBL SUPT5H PAK4

2.00e-0457523M9044
CoexpressionMYLLYKANGAS_AMPLIFICATION_HOT_SPOT_22

EWSR1 MN1

2.10e-0411522M11594
CoexpressionAtlasMESO-15 amniotic fluid MSC_vs_MESO-15 blastocyst-Confounder_removed-fold2.0_adjp0.05

CASC3 RBMXL1 TSPOAP1 FBL RBMX DHX57 E2F3 DHX33 GPC2 GPR162 MN1 NUP153 SOCS7

2.68e-0514795013PCBC_ratio_MESO-15 amniotic fluid MSC_vs_MESO-15 blastocyst_cfr-2X-p05
ToppCellHippocampus-Macroglia-POLYDENDROCYTE|Hippocampus / BrainAtlas - Mouse McCarroll V32

ILF2 RBMX PAK4 EWSR1 GPC2 CHTOP

8.53e-081885268bd6f2cd1aadbd6f9ed31b160f59c1eff144e1dc
ToppCellHSPCs|World / Lineage and Cell class

G3BP1 RBMXL1 FBL EWSR1 NCL

3.53e-06199525df1ffc416c6946f1ba182f242a50ee41a571d565
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5|Hippocampus / BrainAtlas - Mouse McCarroll V32

ILF2 RBMX EWSR1 GPC2

5.77e-0518052444988c34861df359a68376500c42a64fbcc4b431
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial-intestinal_crypt_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

G3BP1 RBMXL1 FBL EWSR1

7.12e-05190524933c778bb8ec89621906fe7d484c1d2c6cd28d80
ToppCellE12.5|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ILF2 G3BP1 FBL NCL

7.72e-051945244b335e4da58de1cd94194dc4208ce83854e5e50a
ToppCellcontrol-Others-CD34+_GATA2+_cells|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ILF2 FBL RBMX NCL

8.03e-0519652425994ca143701c72d2f84a3b6d348fcfa1d26a54
ToppCellmild-Others-CD34+_GATA2+_cells|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FXR1 FBL RBMX ERMP1

8.19e-05197524a375edbc885ae069f9abcd8d5886fdaa8913f83d
ToppCellCV-Severe-2|Severe / Virus stimulation, Condition and Cluster

MSC G3BP1 FBL NCL

8.35e-05198524254659bb53dc2511c714295c2df1ab1fddb2f867
ToppCell10x5'v1-week_12-13-Lymphocytic_B-B_lineage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ILF2 RBMX EWSR1 TAF15

8.51e-05199524ea75804c34989c99aab542e6d72617ed144819b6
ToppCellMegakaryocytic-erythropoietic-Erythro-cells-Basophilic_Erythroblast|Megakaryocytic-erythropoietic / Lineage, cell class and subclass

ILF2 FBL RBMX NCL

8.51e-051995246f159c1215439ec22374903124085746fa8da333
ToppCellCD8+_Memory_T_cell-CV-2|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

MSC G3BP1 FBL NCL

8.51e-051995241e33d8e2e0d6a54ef6e2e13f986e19fd209275a8
ToppCell10x5'v1-week_12-13-Lymphocytic_B|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ILF2 RBMX EWSR1 TAF15

8.51e-05199524713dfd8552635645db5e0b5721c64e5c9b4aa06c
ToppCellmegakaryocytic-CD34+_Megakaryoblast|megakaryocytic / Lineage and Cell class

ILF2 FBL RBMX NCL

8.51e-0519952499a65887d3c8a2cde26693dd74404b101bba9d58
ToppCellCV-Moderate-2|CV / Virus stimulation, Condition and Cluster

G3BP1 FBL LSM4 NCL

8.51e-051995242d98424a5247e87f98095c11fb945289092a9d75
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Mesoderm|5w / Sample Type, Dataset, Time_group, and Cell type.

ZNF142 TSNARE1 RRAS PURG

8.68e-052005240927061536a664b4f7feb9e5b0a8c11ca0d5955c
ToppCell5'-GW_trimst-1|5' / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ILF2 RBMX LSM4 GPC2

8.68e-05200524a4c6d0cccba7aee35eaedf29faff32b9494b6582
ComputationalNeighborhood of MLH1

ILF2 RBMX NCL NUP153

8.58e-0642344GNF2_MLH1
ComputationalNeighborhood of FBL

ILF2 FBL RBMX LSM4 NCL

7.16e-05140345MORF_FBL
ComputationalNeighborhood of KPNB1

FBL RBMX NCL NUP153

7.78e-0573344GNF2_KPNB1
ComputationalNeighborhood of PCNA

G3BP1 FBL RBMX NCL

1.28e-0483344MORF_PCNA
ComputationalNeighborhood of TDG

RBMX NCL NUP153

1.77e-0435343GNF2_TDG
ComputationalNeighborhood of APEX1

ILF2 FBL RBMX NCL

1.91e-0492344GNF2_APEX1
ComputationalNeighborhood of ANP32B

FXR1 ILF2 NCL

1.92e-0436343GCM_ANP32B
ComputationalNeighborhood of DEK

RBMX NCL NUP153

7.92e-0458343GNF2_DEK
ComputationalTFs and nuclear.

ILF2 NFATC4 E2F3 EWSR1 NUP153

8.24e-04237345MODULE_252
ComputationalGenes in the cancer module 32.

ILF2 FBL RBMX EWSR1 NCL

8.89e-04241345MODULE_32
ComputationalNeighborhood of RPA1

ILF2 G3BP1 RBMX

9.18e-0461343MORF_RPA1
ComputationalNeighborhood of SMC1L1

G3BP1 RBMX NCL

9.63e-0462343MORF_SMC1L1
ComputationalGenes in the cancer module 98.

ILF2 NFATC4 FBL E2F3 EWSR1 NUP153

1.30e-03393346MODULE_98
ComputationalNeighborhood of NPM1

FBL RBMX NCL

1.49e-0372343GNF2_NPM1
ComputationalNeighborhood of BUB3

ILF2 FBL RBMX LSM4 NCL

1.65e-03277345MORF_BUB3
ComputationalNeighborhood of XRCC5

ILF2 RBMX NCL

1.67e-0375343GNF2_XRCC5
ComputationalNeighborhood of SOD1

ILF2 G3BP1 FBL RBMX LSM4

1.68e-03278345MORF_SOD1
ComputationalNeighborhood of G22P1

ILF2 FBL RBMX NCL

2.02e-03172344MORF_G22P1
ComputationalGenes in the cancer module 198.

ILF2 NFATC4 E2F3 EWSR1 NUP153

2.45e-03303345MODULE_198
ComputationalNeighborhood of SMC1L1

RBMX NUP153

3.24e-0327342GNF2_SMC1L1
ComputationalNeighborhood of RPA1

RBMX NUP153

3.49e-0328342GNF2_RPA1
Diseaseamyotrophic lateral sclerosis type 6 (implicated_via_orthology)

EWSR1 TAF15

8.78e-063512DOID:0060198 (implicated_via_orthology)
DiseaseExtraskeletal Myxoid Chondrosarcoma

EWSR1 TAF15

2.92e-055512C1275278
DiseaseAmyotrophic Lateral Sclerosis

ATXN2 EWSR1 TAF15

1.40e-0458513C0002736
Diseasefrontotemporal dementia (implicated_via_orthology)

EWSR1 TAF15

1.91e-0412512DOID:9255 (implicated_via_orthology)
Diseasebipolar disorder, sex interaction measurement

TSNARE1 TUSC1

4.40e-0418512EFO_0008343, MONDO_0004985
Diseaseeye measurement

ZNF469 ATXN2

1.00e-0327512EFO_0004731
Diseaseamyotrophic lateral sclerosis (implicated_via_orthology)

EWSR1 TAF15

1.24e-0330512DOID:332 (implicated_via_orthology)
Diseaseinterleukin 2 receptor antagonist measurement

ZNF469 LSM4

1.68e-0335512EFO_0008332
DiseaseMitral valve prolapse

ATXN2 MN1

1.78e-0336512HP_0001634
Diseasespleen volume

ATXN2 KIF1C

2.53e-0343512EFO_0600047

Protein segments in the cluster

PeptideGeneStartEntry
RRTLSLQPGGGGGGG

ADGRB2

1356

O60241
GRRGGRGGPGKMDKG

EWSR1

631

Q01844
TGRGKPRLGGGSGLG

GUSBP11

6

Q6P575
GGRTRKRSPGGSGGA

ERMP1

46

Q7Z2K6
KRSPGGSGGASRGAG

ERMP1

51

Q7Z2K6
GGGKGVTRSRNGGKG

ARMCX2

281

Q7L311
RGRGGFQGRGGDPKS

TAF15

341

Q92804
GGRGGSGGTRGPPSR

RBMX

111

P38159
MPGLVGGSSRRRGGG

TSPOAP1

1396

O95153
GRGSGKRGRRGGGGL

MBD6

851

Q96DN6
PAGGKRGRGAKGSGR

NOP9

16

Q86U38
KGGGGGRAGGPERRT

MCTP1

36

Q6DN14
ARRVGGGGGTKAGGP

GPR162

216

Q16538
RRDGSGGKGGGGSAR

GPC2

531

Q8N158
GGRGRGGPRGGKSSI

FXR1

451

P51114
GGRGGGKGKGRAEGS

LRRC47

261

Q8N1G4
GAPRGGGRGGTSAGR

METTL14

411

Q9HCE5
GGGRPGLGRGRNSNK

ATXN2

236

Q99700
SGGNRGRGRGGKRGN

FBL

66

P22087
GLQGSGGRGGGLRRP

KIF1C

951

O43896
KPKGEGGFGGRGGGR

NCL

646

P19338
GRGRGRPPSGGSGLG

MBD2

91

Q9UBB5
GGGGSGSLPSQRGGR

CASC3

41

O15234
RGGSGGGGGPPAKRR

E2F3

121

O00716
PGEQPRGGGAGGRGR

CCDC9

116

Q9Y3X0
NRLRGPGGPRGGLGG

G3BP1

426

Q13283
PGKGGGKGSSRGGRG

DHX57

11

Q6P158
GRFGSRGGPGGGFRP

ILF2

11

Q12905
GGRGGGGGRRQQPPL

DHX33

41

Q9H6R0
VFGGRGRGGIPGTGR

LSM4

111

Q9Y4Z0
GGGGATGGSPGERKR

DDHD1

131

Q8NEL9
KRPRGGGAGGSSVGT

RING1

201

Q06587
RGGPGKAGSRGRFAG

PAK4

126

O96013
RRGGGGGRGRGGKNV

PURG

6

Q9UJV8
GGTGGKGKSGGRFRL

IRS4

641

O14654
APGTGRGRGRPKGSG

MECP2

181

P51608
DGKPVSGGGGRGRGR

MN1

931

Q10571
PRGFGAGRGGSGGTR

RBMXL1

106

Q96E39
AGRGGSGGTRGPPSR

RBMXL1

111

Q96E39
RSVRLGGPGGGAGGA

NFATC4

91

Q14934
GGRGPRRGPAGGGEK

NOM1

26

Q5C9Z4
SPGGGSGGMSRGRGR

SUPT5H

686

O00267
VRGRGGPGRGGLGRG

CHTOP

156

Q9Y3Y2
IARGGGLGSRGPFGG

TSNARE1

6

Q96NA8
KGRRPGVGAGAGGRG

TMEM214

16

Q6NUQ4
RRKSPGGGGGGGSGN

CREBZF

186

Q9NS37
GGVGGGGGGKIRTRR

NUP153

6

P49790
ELSSPGRGGGGGGRL

SOCS7

136

O14512
GSGSGGGGRASGLRP

ZNF469

966

Q96JG9
GGRGGGGKRGTPQTQ

ZNF142

1051

P52746
ASGTGRGRPRGGGPG

RRAS

6

P10301
GGGGGPAGGQRSLQR

RAPGEFL1

41

Q9UHV5
RSGRARGGGSPSGGG

TUSC1

31

Q2TAM9
KRKRPRVAGGGGAGG

MSC

71

O60682