Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	organofluorine metabolic process	CYP2D6 POR	1.14e-05	2	70	2	GO:0090346
GeneOntologyBiologicalProcess	organohalogen metabolic process	CYP2D6 POR	1.14e-05	2	70	2	GO:0090345
GeneOntologyCellularComponent	t-UTP complex	NOL11 HEATR1	3.40e-05	3	71	2	GO:0034455
MousePheno	abnormal renal tubule epithelial cell primary cilium morphology	TMEM67 WWTR1 ARHGAP35	2.78e-05	16	53	3	MP:0011066
MousePheno	increased tumor incidence following infection	RAG1 SAMD9L	8.42e-05	4	53	2	MP:0012563
MousePheno	abnormal kidney epithelial cell primary cilium morphology	TMEM67 WWTR1 ARHGAP35	8.64e-05	23	53	3	MP:0011065
Domain	Adaptor_Cbl_EF_hand-like	CBL CBLB	4.63e-05	3	74	2	IPR014741
Domain	Adaptor_Cbl_SH2-like	CBL CBLB	4.63e-05	3	74	2	IPR014742
Domain	Cbl_N2	CBL CBLB	4.63e-05	3	74	2	PF02761
Domain	Cbl_N3	CBL CBLB	4.63e-05	3	74	2	PF02762
Domain	Cbl_N	CBL CBLB	4.63e-05	3	74	2	PF02262
Domain	Adaptor_Cbl_N_hlx	CBL CBLB	4.63e-05	3	74	2	IPR003153
Domain	CBL_PTB	CBL CBLB	4.63e-05	3	74	2	PS51506
Domain	Adaptor_Cbl	CBL CBLB	4.63e-05	3	74	2	IPR024162
Domain	Cbl_PTB	CBL CBLB	4.63e-05	3	74	2	IPR024159
Domain	-	CBL CBLB	4.63e-05	3	74	2	1.20.930.20
Domain	Pept_M10A_stromelysin-type	MMP24 MMP21 MMP12	4.67e-05	18	74	3	IPR016293
Domain	PG_binding_1	MMP24 MMP21 MMP12	6.48e-05	20	74	3	PF01471
Domain	Peptidoglycan-bd-like	MMP24 MMP21 MMP12	6.48e-05	20	74	3	IPR002477
Domain	Hemopexin-like_dom	MMP24 MMP21 MMP12	9.99e-05	23	74	3	IPR000585
Domain	Hemopexin-like_repeat	MMP24 MMP21 MMP12	9.99e-05	23	74	3	IPR018487
Domain	M10A_MMP	MMP24 MMP21 MMP12	9.99e-05	23	74	3	IPR033739
Domain	Hemopexin	MMP24 MMP21 MMP12	9.99e-05	23	74	3	PF00045
Domain	HEMOPEXIN	MMP24 MMP21 MMP12	9.99e-05	23	74	3	PS00024
Domain	-	MMP24 MMP21 MMP12	9.99e-05	23	74	3	2.110.10.10
Domain	HEMOPEXIN_2	MMP24 MMP21 MMP12	9.99e-05	23	74	3	PS51642
Domain	HX	MMP24 MMP21 MMP12	9.99e-05	23	74	3	SM00120
Domain	Pept_M10A	MMP24 MMP21 MMP12	9.99e-05	23	74	3	IPR021190
Domain	Peptidase_M10	MMP24 MMP21 MMP12	1.14e-04	24	74	3	PF00413
Domain	RETICULON	RTN4 RTN3	1.54e-04	5	74	2	PS50845
Domain	ZnMc	MMP24 MMP21 MMP12	2.03e-04	29	74	3	SM00235
Domain	Peptidase_Metallo	MMP24 MMP21 MMP12	2.03e-04	29	74	3	IPR006026
Domain	Reticulon	RTN4 RTN3	3.21e-04	7	74	2	PF02453
Domain	Reticulon	RTN4 RTN3	4.27e-04	8	74	2	IPR003388
Domain	CYSTEINE_SWITCH	MMP24 MMP21 MMP12	5.71e-04	41	74	3	PS00546
Domain	Pept_M10_metallopeptidase	MMP24 MMP21 MMP12	6.58e-04	43	74	3	IPR001818
Domain	MATH/TRAF_dom	SPOPL SPOP	9.96e-04	12	74	2	IPR002083
Domain	MATH	SPOPL SPOP	9.96e-04	12	74	2	PS50144
Domain	MATH	SPOPL SPOP	9.96e-04	12	74	2	SM00061
Domain	MATH	SPOPL SPOP	9.96e-04	12	74	2	PF00917
Domain	-	SPOPL SPOP	1.37e-03	14	74	2	2.60.210.10
Domain	Hemopexin_CS	MMP24 MMP12	2.03e-03	17	74	2	IPR018486
Domain	C2	SYTL5 PKN1 FER1L6 NEDD4	2.14e-03	137	74	4	SM00239
Domain	C2	SYTL5 PKN1 FER1L6 NEDD4	2.44e-03	142	74	4	PS50004
Domain	-	SYTL5 PKN1 FER1L6 NEDD4	2.83e-03	148	74	4	2.60.40.150
Domain	Cyclophilin-like_dom	RANBP2 PPWD1	3.40e-03	22	74	2	IPR029000
Domain	CSA_PPIASE_2	RANBP2 PPWD1	3.40e-03	22	74	2	PS50072
Domain	Pro_isomerase	RANBP2 PPWD1	3.40e-03	22	74	2	PF00160
Domain	-	RANBP2 PPWD1	3.40e-03	22	74	2	2.40.100.10
Domain	Cyclophilin-type_PPIase_dom	RANBP2 PPWD1	3.40e-03	22	74	2	IPR002130
Domain	CSA_PPIASE_1	RANBP2 PPWD1	3.40e-03	22	74	2	PS00170
Domain	-	CAPN9 EPS15L1 PPP2R3B CBL CBLB	3.77e-03	261	74	5	1.10.238.10
Pubmed	Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells.	RAG1 CBL CBLB	9.25e-09	3	74	3	34630435
Pubmed	Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.	EPS15L1 CBL CBLB NEDD4	1.33e-08	13	74	4	12218189
Pubmed	Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.	RAG1 CBL CBLB	1.51e-06	11	74	3	29562201
Pubmed	Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.	KIAA1210 RANBP2 EPS15L1 RTN3 NEDD4	3.91e-06	110	74	5	37219487
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	NCAPD3 RANBP2 MYBBP1A ACACA EIF4A3 UBE3C	4.12e-06	197	74	6	31620119
Pubmed	Germline loss-of-function SAMD9 and SAMD9L alterations in adult myelodysplastic syndromes.	SAMD9L SAMD9	4.47e-06	2	74	2	30322869
Pubmed	A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.	SPOPL SPOP	4.47e-06	2	74	2	16740475
Pubmed	Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.	CBL CBLB	4.47e-06	2	74	2	25871390
Pubmed	Evolutionary expansion of SPOP and associated TD/POZ gene family: impact of evolutionary route on gene expression pattern.	SPOPL SPOP	4.47e-06	2	74	2	20399258
Pubmed	RTN3 and RTN4: Architects of SARS-CoV-2 replication organelles.	RTN4 RTN3	4.47e-06	2	74	2	37318453
Pubmed	Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.	CBL CBLB	4.47e-06	2	74	2	17056522
Pubmed	Pro-apoptotic ASY/Nogo-B protein associates with ASYIP.	RTN4 RTN3	4.47e-06	2	74	2	12811824
Pubmed	SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies.	SAMD9L SAMD9	4.47e-06	2	74	2	29535429
Pubmed	E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.	CBLB NEDD4	4.47e-06	2	74	2	22763434
Pubmed	Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes.	SAMD9L SAMD9	4.47e-06	2	74	2	34621053
Pubmed	Association of a new c-Cbl related protein with the very first stages of apoptosis induction.	CBL CBLB	4.47e-06	2	74	2	12102152
Pubmed	Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.	SAMD9L SAMD9	4.47e-06	2	74	2	33731850
Pubmed	Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing.	CBL CBLB	4.47e-06	2	74	2	32584413
Pubmed	A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.	CBL CBLB	4.47e-06	2	74	2	27276677
Pubmed	Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia.	CBL CBLB	4.47e-06	2	74	2	17475912
Pubmed	Aberrant SPOP-CHAF1A ubiquitination axis triggers tumor autophagy that endows a therapeutical vulnerability in diffuse large B cell lymphoma.	CHAF1A SPOP	4.47e-06	2	74	2	35773729
Pubmed	Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation.	RTN4 RTN3	4.47e-06	2	74	2	18779370
Pubmed	WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation.	CBLB NEDD4	4.47e-06	2	74	2	12907674
Pubmed	[Pancytopenia in children caused by SAMD9/9L mutation: 5 cases report and literature review].	SAMD9L SAMD9	4.47e-06	2	74	2	37357006
Pubmed	Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.	CBL CBLB	4.47e-06	2	74	2	26177294
Pubmed	The role of E3 ubiquitin ligase Cbl proteins in β-elemene reversing multi-drug resistance of human gastric adenocarcinoma cells.	CBL CBLB	4.47e-06	2	74	2	23665906
Pubmed	Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy.	CBL CBLB	4.47e-06	2	74	2	24994594
Pubmed	Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication.	RTN4 RTN3	4.47e-06	2	74	2	37093123
Pubmed	A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection.	SAMD9L SAMD9	4.47e-06	2	74	2	29447249
Pubmed	The Implication of Reticulons (RTNs) in Neurodegenerative Diseases: From Molecular Mechanisms to Potential Diagnostic and Therapeutic Approaches.	RTN4 RTN3	4.47e-06	2	74	2	33924890
Pubmed	RTN3 and RTN4: Candidate modulators in vascular cell apoptosis and atherosclerosis.	RTN4 RTN3	4.47e-06	2	74	2	20717916
Pubmed	Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.	SPOPL SPOP	4.47e-06	2	74	2	16651542
Pubmed	Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse.	SAMD9L SAMD9	4.47e-06	2	74	2	17407603
Pubmed	c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation.	CBL CBLB	4.47e-06	2	74	2	12415267
Pubmed	Viral host range factors antagonize pathogenic SAMD9 and SAMD9L variants.	SAMD9L SAMD9	4.47e-06	2	74	2	36894052
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RIOX2 NCAPD3 RANBP2 MYBBP1A ACACA EIF4A3 CHAF1A RTN4 NOL11 POR RTN3 HEATR1 UBE3C	8.85e-06	1425	74	13	30948266
Pubmed	Expression of c-Cbl, Cbl-b, and epidermal growth factor receptor in gastric carcinoma and their clinical significance.	CBL CBLB	1.34e-05	3	74	2	20038312
Pubmed	Regulation of immune responses by E3 ubiquitin-protein ligases.	CBL CBLB	1.34e-05	3	74	2	11826757
Pubmed	Cbl-b regulates the CD28 dependence of T-cell activation.	CBL CBLB	1.34e-05	3	74	2	10646609
Pubmed	Cbl-b and c-Cbl negatively regulate osteoblast differentiation by enhancing ubiquitination and degradation of Osterix.	CBL CBLB	1.34e-05	3	74	2	25744063
Pubmed	A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.	CBL CBLB	1.34e-05	3	74	2	10074432
Pubmed	E3 ubiquitin ligases Cbl-b and c-Cbl downregulate PD-L1 in EGFR wild-type non-small cell lung cancer.	CBL CBLB	1.34e-05	3	74	2	29364514
Pubmed	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	CBL CBLB	1.34e-05	3	74	2	12874286
Pubmed	Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion.	RTN4 RTN3	1.34e-05	3	74	2	24262037
Pubmed	Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.	CBL CBLB	1.34e-05	3	74	2	31282857
Pubmed	Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease.	RAG1 CBLB	1.34e-05	3	74	2	19017948
Pubmed	Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights.	CBL CBLB	1.34e-05	3	74	2	18596201
Pubmed	Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.	CBL CBLB	1.34e-05	3	74	2	15265912
Pubmed	[Expressions of c-Cbl, Cbl-b and EGFR and its role of prognosis in NSCLC].	CBL CBLB	1.34e-05	3	74	2	21645455
Pubmed	T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation.	CBL CBLB	1.34e-05	3	74	2	23684068
Pubmed	Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins.	RTN4 RTN3	1.34e-05	3	74	2	16979658
Pubmed	Cbl regulates the activity of SIRT2.	CBL CBLB	1.34e-05	3	74	2	25285640
Pubmed	VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease.	CBL CBLB	1.34e-05	3	74	2	27449297
Pubmed	PARP14 correlates with GBM proliferation and poor prognosis by elevating expression of SAMD/SAMD9L.	SAMD9L SAMD9	1.34e-05	3	74	2	37612499
Pubmed	Cbl and Cbl-b independently regulate EGFR through distinct receptor interaction modes.	CBL CBLB	1.34e-05	3	74	2	37903221
Pubmed	Germline predisposition in myeloid neoplasms: Unique genetic and clinical features of GATA2 deficiency and SAMD9/SAMD9L syndromes.	SAMD9L SAMD9	1.34e-05	3	74	2	33038986
Pubmed	Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.	CBL CBLB	1.34e-05	3	74	2	19268472
Pubmed	Cbl negatively regulates JNK activation and cell death.	CBL CBLB	1.34e-05	3	74	2	19546888
Pubmed	The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T lymphocytes.	CBL CBLB	1.34e-05	3	74	2	17330819
Pubmed	A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation.	CBL CBLB	1.34e-05	3	74	2	18316398
Pubmed	CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis.	CYP2D6 POR	1.34e-05	3	74	2	19448135
Pubmed	A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins.	EPS15L1 NEDD4	1.34e-05	3	74	2	11919637
Pubmed	The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1.	RTN4 RTN3	1.34e-05	3	74	2	19405102
Pubmed	c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.	CBL CBLB	1.34e-05	3	74	2	21768087
Pubmed	Prevalence of germline GATA2 and SAMD9/9L variants in paediatric haematological disorders with monosomy 7.	SAMD9L SAMD9	1.34e-05	3	74	2	32770553
Pubmed	Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress.	RTN4 RTN3	1.34e-05	3	74	2	17191123
Pubmed	Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).	CBL CBLB	1.34e-05	3	74	2	15315962
Pubmed	Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells.	CBL NEDD4	1.34e-05	3	74	2	18931680
Pubmed	The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling.	CBL CBLB	1.34e-05	3	74	2	27048651
Pubmed	Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b.	CBL CBLB	1.34e-05	3	74	2	15273720
Pubmed	Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.	CBL CBLB	1.34e-05	3	74	2	11087752
Pubmed	The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes.	CBL CBLB	1.34e-05	3	74	2	38170572
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	MRPL50 NCAPD3 RANBP2 GOPC AGL CHAF1A WWTR1 HEATR1 PRDM15 JMJD1C	1.35e-05	857	74	10	25609649
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP24 MMP21 MMP12	1.38e-05	22	74	3	23421805
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	RIOX2 NCAPD3 EPS15L1 CHAF1A POR ARHGAP35 CBL USP48 PRDM15	1.57e-05	689	74	9	36543142
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	RANBP2 EPS15L1 MYBBP1A RTN4 HEATR1 JMJD1C	1.83e-05	256	74	6	33397691
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	NCAPD3 RANBP2 MYBBP1A ACACA EIF4A3 AGL NOL11 HTATSF1 HEATR1	1.85e-05	704	74	9	29955894
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EPS15L1 MYBBP1A ACACA WWTR1 HEATR1 ARHGAP35 CBL JMJD1C	2.21e-05	549	74	8	38280479
Pubmed	IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.	CBL CBLB	2.67e-05	4	74	2	29237719
Pubmed	Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia.	SERPINA1 ARHGAP35	2.67e-05	4	74	2	28387812
Pubmed	SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells.	RAG1 CBL	2.67e-05	4	74	2	38019655
Pubmed	Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.	ACACA PCK1	2.67e-05	4	74	2	38447582
Pubmed	Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome.	RIOX2 JMJD1C	2.67e-05	4	74	2	26608785
Pubmed	Evidence for direct interaction between Sprouty and Cbl.	CBL CBLB	2.67e-05	4	74	2	11053437
Pubmed	Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection.	RANBP2 SP100	2.67e-05	4	74	2	15608651
Pubmed	CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.	CBL CBLB	2.67e-05	4	74	2	29729186
Pubmed	Cbl promotes clustering of endocytic adaptor proteins.	CBL CBLB	2.67e-05	4	74	2	16228008
Pubmed	An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.	CBL CBLB	2.67e-05	4	74	2	28100467
Pubmed	Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.	CBL CBLB	2.67e-05	4	74	2	19815501
Pubmed	Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.	CBL CBLB	2.67e-05	4	74	2	20951942
Pubmed	Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.	RTN4 RTN3	2.67e-05	4	74	2	16965550
Pubmed	H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.	CBL CBLB	2.67e-05	4	74	2	26353930
Pubmed	The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.	CBL CBLB	2.67e-05	4	74	2	12935897
Pubmed	Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.	CBL CBLB	2.67e-05	4	74	2	20805496
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCAPD3 RANBP2 EPS15L1 MYBBP1A ACACA CHAF1A PKN1 ARHGAP35 MED13	3.88e-05	774	74	9	15302935
Pubmed	T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells.	RAG1 CBLB	4.45e-05	5	74	2	23749633
Pubmed	Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.	CBL CBLB	4.45e-05	5	74	2	17020880
Pubmed	Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins.	CBL CBLB	4.45e-05	5	74	2	18239087
Pubmed	Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization.	CBL NEDD4	4.45e-05	5	74	2	28794017
Pubmed	Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.	SPOPL SPOP	4.45e-05	5	74	2	22632832
Cytoband	7q21.2	SAMD9L SAMD9	2.65e-04	15	74	2	7q21.2
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP24 MMP21 MMP12	3.21e-05	24	47	3	891
GeneFamily	Cyclophilin peptidylprolyl isomerases	RANBP2 PPWD1	1.10e-03	19	47	2	909
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 PRUNE2 FSIP2 SERPINA1 SYTL5 FER1L6	9.17e-07	196	74	6	847b3377f463bfded046eec63cc1b547f3dc33c1
ToppCell	BAL-Control-cDC_1\|Control / Compartment, Disease Groups and Clusters	SP100 SAMD9L SAMD9 CYP2D6 OAS3	1.15e-05	177	74	5	aa021f6d62e9d740c5ea499faaf875de835a2865
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	OTOA SAMD9L SAMD9 APOL3 OAS3	1.22e-05	179	74	5	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	SP100 SAMD9L SAMD9 OAS3 JMJD1C	1.35e-05	183	74	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ZNF10 RANBP2 CBLB JMJD1C MED13	1.54e-05	188	74	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	SP100 SAMD9L SAMD9 APOL3 OAS3	1.54e-05	188	74	5	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	RA-11._Adipocyte\|World / Chamber and Cluster_Paper	PRUNE2 ACACA RTN4 RTN3 PCK1	1.54e-05	188	74	5	4dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCell	Calu_3-infected-SARSCoV2\|infected / Cell line, Condition and Strain	SP100 SAMD9L SAMD9 APOL3 OAS3	1.66e-05	191	74	5	2da876d26f37a00dbdf1ee79d724306e8b20f304
ToppCell	Mild/Remission-B_activate-7\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SP100 SAMD9L SAMD9 OAS3 JMJD1C	1.66e-05	191	74	5	382686d62f7b8576c44bb9726a4e10dc26fd348e
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 PRUNE2 FSIP2 SYTL5 FER1L6	1.79e-05	194	74	5	49cc5f5de4380302100e8cd937f08abe317ac75e
ToppCell	3'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 PRUNE2 SERPINA1 SYTL5 FER1L6	1.79e-05	194	74	5	1a188e52f2f0b6eca3e8d4a4671d9beab0fbbb88
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 PRUNE2 FSIP2 SYTL5 FER1L6	1.79e-05	194	74	5	fb935df966c451e659b8bde281f8aebcb632f6cf
ToppCell	Mild/Remission-B_activate-7\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SP100 SAMD9L SAMD9 OAS3 JMJD1C	1.79e-05	194	74	5	01c97543972159a9468272da06e7e611e2c21fae
ToppCell	COVID-19_Moderate-CD8+_T_activated\|World / disease group, cell group and cell class	SP100 SAMD9L SAMD9 OAS3 CBLB	1.84e-05	195	74	5	070c5d3bdbd4ea54a579c01c37fb99bcf823982e
ToppCell	3'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 PRUNE2 SERPINA1 SYTL5 FER1L6	1.84e-05	195	74	5	3365768101454060b9ea96ef6b426c76c150bc8f
ToppCell	mild-Myeloid-Neutrophils_2\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SERPINA1 SAMD9L SAMD9 RTN3 OAS3	1.88e-05	196	74	5	e9f30eb8a3915c3b2af009c832bff9b349b65ae5
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RANBP2 SP100 SERPINA1 SAMD9L SCIN	1.88e-05	196	74	5	e54c08f88779f9fd453a4f5b85aed1f460d8a1e1
ToppCell	severe-Myeloid-Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SP100 SERPINA1 SAMD9L SAMD9 OAS3	1.93e-05	197	74	5	c8a90d82170cf20e14aebecddcf7cc0ca56cda87
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 PRUNE2 SERPINA1 SYTL5 FER1L6	1.93e-05	197	74	5	d624f3a105b19f19a0dd253ce8de3ed13adc1f01
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	SP100 SAMD9L SAMD9 OAS3 JMJD1C	1.93e-05	197	74	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	CD8+_Memory_T_cell-CV-1\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	SP100 SAMD9L SAMD9 APOL3 OAS3	1.93e-05	197	74	5	e59b47bccc781b2117196fe322efa87559c237c6
ToppCell	control-Myeloid-Neutrophils_2\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SP100 SERPINA1 SAMD9L SAMD9 OAS3	1.93e-05	197	74	5	8819db1550bf14566c6d33d97f7f83419e867ace
ToppCell	CV-Severe-1\|Severe / Virus stimulation, Condition and Cluster	SP100 SAMD9L SAMD9 APOL3 OAS3	1.98e-05	198	74	5	9b9ee0b0f6cc92e7be94869604c98f43d57ff8ff
ToppCell	CV-Severe-1\|CV / Virus stimulation, Condition and Cluster	SP100 SAMD9L SAMD9 APOL3 OAS3	1.98e-05	198	74	5	fc0e885e370ffb780eada62bb2b52065c2f8b26b
ToppCell	severe-Myeloid-Neutrophils_2\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SP100 SERPINA1 SAMD9L SAMD9 OAS3	1.98e-05	198	74	5	636878836678a0715550fa09f2e3dac11c4d73fe
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	SP100 SAMD9L SAMD9 OAS3 JMJD1C	1.98e-05	198	74	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	Mild-CD8+_T_activated\|Mild / Disease group and Cell class	SP100 SAMD9L SAMD9 OAS3 CBLB	1.98e-05	198	74	5	ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SP100 SAMD9L SAMD9 OAS3 JMJD1C	1.98e-05	198	74	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	BAL-Severe-cDC_1\|Severe / Compartment, Disease Groups and Clusters	SERPINA1 SAMD9L SAMD9 OAS3 SCIN	2.02e-05	199	74	5	9f5750212b887f92761ade33fc6e108cd5275297
ToppCell	BAL-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	SP100 SAMD9L SAMD9 OAS3 SCIN	2.02e-05	199	74	5	c55181bdec8952b54198f0d4c9c5c84265b16572
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SP100 SAMD9L SAMD9 OAS3 JMJD1C	2.07e-05	200	74	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Healthy-CD4+_T_activated\|Healthy / disease group, cell group and cell class	SYCP2 SAMD9L CYP2D6 OAS3	9.99e-05	145	74	4	45e8089fdf7d6f69b383816d8945e39fba24c873
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GABRR2 SLC14A2 FER1L6	1.17e-04	57	74	3	5ae53d915bee8a5fc7936d2a46517da1b6abbf79
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2-Inhibitory_Gad1Gad2_Htr3a.Chrm2_(Interneuron,__(candidate_CGE-derived_10))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GABRR2 SLC14A2 FER1L6	1.17e-04	57	74	3	e61b10212685e5217550db0812141a1f3f6567c8
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2-Inhibitory_Gad1Gad2_Htr3a.Chrm2_(Interneuron,__(candidate_CGE-derived_10))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GABRR2 SLC14A2 FER1L6	1.17e-04	57	74	3	f5edb5e8eddc51e0b8040e88baa5d8971871f9ea
ToppCell	MS-CD4-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	SP100 SAMD9L SAMD9 OAS3	1.20e-04	152	74	4	b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	ZNF10 RANBP2 CBLB JMJD1C	1.32e-04	156	74	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CAPN9 SERPINA1 SYTL5 FER1L6	1.36e-04	157	74	4	5fb41af247465aa29aa7b8edd26e3d3794766f80
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRUNE2 RGN WDR87 WWTR1	1.36e-04	157	74	4	29622bac6b16bb39cec4319bf4c4f92d33345e8a
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SAMD9L SAMD9 OAS3 CNTN1	1.57e-04	163	74	4	d005115aa1e1458b51de7eb719794617a4168608
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCHE SCIN PCK1 CNTN1	1.57e-04	163	74	4	1eec7f5e5fed05fa21d3f81db588f10605f08ea7
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FSIP2 OAS3 HYDIN NEDD4	1.64e-04	165	74	4	436ce4bc75e1ba4351c439ccad19f84ad5bcb92f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FSIP2 OAS3 HYDIN NEDD4	1.64e-04	165	74	4	242bdb7654f415391fb8e9bdc06412c7eee9c97e
ToppCell	COVID-19_Severe-CD4+_T_activated\|COVID-19_Severe / Disease condition and Cell class	SP100 SAMD9L SAMD9 OAS3	1.68e-04	166	74	4	0f138dbafad6f83975944e8f6398411127b150cc
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 PRUNE2 SERPINA1 FER1L6	1.88e-04	171	74	4	48125d825ca2d7ef34564250f5b47d2a579e03c9
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	CAPN9 FSIP2 MMP24 SYTL5	1.93e-04	172	74	4	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	RSV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	SP100 SAMD9L SAMD9 OAS3	2.06e-04	175	74	4	ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SP100 SAMD9L SAMD9 OAS3	2.06e-04	175	74	4	97616bb5c127284aa9e67bc336dfcf29e137164b
ToppCell	RSV-Healthy-1\|RSV / Virus stimulation, Condition and Cluster	SP100 SAMD9L SAMD9 OAS3	2.06e-04	175	74	4	ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FSIP2 TRPM5 SLC14A2	2.07e-04	69	74	3	4831573a45ace5f06cd409f0e75bce838ed65a88
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ADCK1 UBE3C SCIN PRDM15	2.20e-04	178	74	4	9d575902d3dbe33437c9d4200df093a741269803
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	ADCK1 UBE3C SCIN PRDM15	2.20e-04	178	74	4	536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1\|TCGA-Adrenal / Sample_Type by Project: Shred V9	PRUNE2 RANBP2 SPOPL HTATSF1	2.24e-04	179	74	4	431e1b29015ec817f778499106d24b19cfc825ae
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	ZNF10 RANBP2 CBLB JMJD1C	2.34e-04	181	74	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	HSPA12A ACACA RTN3 PCK1	2.44e-04	183	74	4	b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRUNE2 BCHE WWTR1 CNTN1	2.44e-04	183	74	4	61a73de857f4ae02dcba3af348f436f602b28ff2
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Dlk1_(Zona_Incerta,_ventral_part_(ZIV)_and/or_Lateral_hypothalamus_(LH))-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	RAG1 MMP12 FER1L6	2.45e-04	73	74	3	cfb3d5bbb1d2b6d228c2cfbdc14e6f70860fe1f2
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Dlk1_(Zona_Incerta,_ventral_part_(ZIV)_and/or_Lateral_hypothalamus_(LH))--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	RAG1 MMP12 FER1L6	2.45e-04	73	74	3	23e4ed235e75c7cf2807bd0dda56be7744d0fca0
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Dlk1_(Zona_Incerta,_ventral_part_(ZIV)_and/or_Lateral_hypothalamus_(LH))\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	RAG1 MMP12 FER1L6	2.45e-04	73	74	3	93f1a39aeb4859c2d7c821ce0ebafb7b7a9d81d4
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA SYCP2 HYDIN CNTN1	2.49e-04	184	74	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA SYCP2 HYDIN CNTN1	2.49e-04	184	74	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_prolif-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OTOA SERPINA1 PKN1 SCIN	2.49e-04	184	74	4	65b00145cb7da7d64eb6765569573c1a902a1036
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA SYCP2 HYDIN CNTN1	2.49e-04	184	74	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP100 SAMD9L APOL3 PCK1	2.54e-04	185	74	4	03df43e9c2ce4ec24ffed8e4e2993f94ba951c8b
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SERPINA1 SAMD9L SAMD9 OAS3	2.54e-04	185	74	4	f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial-Endo_L2-5_CLDN5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP100 SAMD9L APOL3 PCK1	2.54e-04	185	74	4	dbdbd6593cd98550238519746bb45fbf0617550b
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Endo\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP100 SAMD9L APOL3 PCK1	2.54e-04	185	74	4	de2c24719946d5a37a982d816776cea7f3984c49
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Sc17a7.Oprk1_(Claustrum?)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FSIP2 TRPM5 SLC14A2	2.55e-04	74	74	3	0feb6bd4c4277f62a4f596370c00ed64e79a389b
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Sc17a7.Oprk1_(Claustrum?)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FSIP2 TRPM5 SLC14A2	2.55e-04	74	74	3	4908cbf8ef5881a01a58c26076bd263f8a5665c2
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Sc17a7.Oprk1_(Claustrum?)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FSIP2 TRPM5 SLC14A2	2.55e-04	74	74	3	c26fdce3f979a2f5280a6adcc980419389aec3cb
ToppCell	critical-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SAMD9L SAMD9 APOL3 OAS3	2.65e-04	187	74	4	72e4aec49ea0c5fe6cee2a1a46369dbc90cd3fad
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RIOX2 SAMD9L CHAF1A CBL	2.65e-04	187	74	4	c667fae6440dc98072b584f203d00f0fb1cb2f21
ToppCell	CV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	SP100 SAMD9L SAMD9 OAS3	2.93e-04	192	74	4	2a2052b44e8f679ef484f03ba4fb37b0ec841b88
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	ZNF10 RANBP2 CBLB JMJD1C	2.93e-04	192	74	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	BAL-Mild\|BAL / Compartment, Disease Groups and Clusters	SAMD9 APOL3 OAS3 SCIN	2.93e-04	192	74	4	1a6cbf014d3f7a3fb6f53adab078c4742e7137de
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SAMD9L APOL3 OAS3	2.97e-04	78	74	3	d5e2e2e04e380b265b2530e93cba6f98ad329e4f
ToppCell	COVID-19_Moderate-CD4+_T_activated\|World / disease group, cell group and cell class	SP100 SAMD9L SAMD9 OAS3	2.99e-04	193	74	4	c2a2a2c14a7085690262db5c2a70e38db67dee18
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 SYTL5 SCIN FER1L6	2.99e-04	193	74	4	402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CAPN9 POR SCIN FER1L6	2.99e-04	193	74	4	605fc2a25ed6846fb283b2918cfed98df6039d6b
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 SYTL5 SCIN FER1L6	2.99e-04	193	74	4	7ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell	moderate-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SAMD9L SAMD9 APOL3 OAS3	2.99e-04	193	74	4	22455801194bd8c73c5c397f5eac4f723429c383
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	SP100 SAMD9L SAMD9 OAS3	2.99e-04	193	74	4	7256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RTN4 WWTR1 SCIN SLC14A2	3.05e-04	194	74	4	46070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-natural_killer_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SPATA31D1 SP100 SAMD9L SAMD9	3.05e-04	194	74	4	a3a81638b55cb5fc08fe83c8b88f68d49b87e6cb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RTN4 WWTR1 SCIN SLC14A2	3.05e-04	194	74	4	abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell	metastatic_Lymph_Node\|World / Location, Cell class and cell subclass	SP100 SAMD9L OAS3 MMP12	3.05e-04	194	74	4	af6b5806238a610443564754367e91ce378c4a6d
ToppCell	PBMC-Mild\|PBMC / Compartment, Disease Groups and Clusters	SP100 SAMD9L SAMD9 OAS3	3.05e-04	194	74	4	d1366b169d14011194e61d16b6b0953349febc78
ToppCell	control-Myeloid-Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SP100 SAMD9L SAMD9 OAS3	3.05e-04	194	74	4	267e213e8efe53aadfe553a2ca010a0e3b4b8939
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-natural_killer_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SPATA31D1 SP100 SAMD9L SAMD9	3.05e-04	194	74	4	0abca32c3547a45cebab0bd69c1f7a0002deaa80
ToppCell	critical-Myeloid-Monocyte-derived_Macrophage\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SAMD9L SAMD9 APOL3 OAS3	3.05e-04	194	74	4	e36d1fd141bdcbd9ed66a33de6cdfde77189a0c1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SAMD9L SAMD9 OAS3 CBLB	3.11e-04	195	74	4	662b50a2aa97373bf343b88caace9717049c722a
ToppCell	PBMC-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	SP100 SAMD9L SAMD9 OAS3	3.11e-04	195	74	4	674355ca00314bde90ef7f6ddb83afe2d5323130
ToppCell	B_cells-ISG-high_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	SAMD9L SAMD9 APOL3 OAS3	3.11e-04	195	74	4	b64d9e1a8834401b4dc501566546647754ae21fc
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 TRPM5 RTN4 CNTN1	3.11e-04	195	74	4	58b769da05a8f6b05aeb08d4f8b112941087ad00
ToppCell	CV-Moderate-1\|Moderate / Virus stimulation, Condition and Cluster	SP100 SAMD9L SAMD9 OAS3	3.17e-04	196	74	4	b50cfcd87c5b67806450cb8b3c6860ab97f6d3b1
ToppCell	mild-Myeloid-Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SP100 SAMD9L SAMD9 OAS3	3.17e-04	196	74	4	ded44b38ea489946e9eedfe752b5a9fde9149c16
ToppCell	Mild-CD4+_T_activated\|Mild / Disease group and Cell class	SP100 SAMD9L SAMD9 OAS3	3.17e-04	196	74	4	daa1c3322d81e649161e889e1d78451d2d425d09
ToppCell	Mild-CD8+_T_activated\|World / Disease group and Cell class	SP100 SAMD9L SAMD9 OAS3	3.17e-04	196	74	4	79632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCell	CV-Severe\|CV / Virus stimulation, Condition and Cluster	SP100 SAMD9L APOL3 OAS3	3.17e-04	196	74	4	d0ddeaaa9ad0576e312a49bd3e68d12addccad3c
ToppCell	Mild-CD4+_T_activated\|World / Disease group and Cell class	SP100 SAMD9L SAMD9 OAS3	3.17e-04	196	74	4	417b4fc2e4388f34c410576131b02936f93e46b6
Disease	Familial monosomy 7 syndrome	SAMD9L SAMD9	5.71e-06	2	71	2	cv:C5681220
Disease	Vasculitis	SERPINA1 CBL	1.71e-05	3	71	2	C0042384
Disease	rho-related GTP-binding protein Rho6 measurement	SERPINA1 BCHE	3.41e-05	4	71	2	EFO_0803022
Disease	hereditary spastic paraplegia 12 (implicated_via_orthology)	RTN4 RTN3	3.41e-05	4	71	2	DOID:0110765 (implicated_via_orthology)
Disease	hereditary spastic paraplegia (implicated_via_orthology)	CAPN9 RTN4 RTN3	1.54e-04	43	71	3	DOID:2476 (implicated_via_orthology)
Disease	cholesterol to total lipids in large VLDL percentage	TDRD15 SERPINA1 JMJD1C	1.76e-04	45	71	3	EFO_0022236
Disease	cholesteryl esters to total lipids in small VLDL percentage	TDRD15 SERPINA1 JMJD1C	2.27e-04	49	71	3	EFO_0022256
Disease	Cryptogenic Tonic-Clonic Epilepsy	CYP2D6 BCHE	2.54e-04	10	71	2	C0751117
Disease	Epilepsy, Tonic-Clonic, Symptomatic	CYP2D6 BCHE	2.54e-04	10	71	2	C0751119
Disease	Epilepsy, Tonic-Clonic, Familial	CYP2D6 BCHE	2.54e-04	10	71	2	C0751118
Disease	adseverin measurement	BCHE SCIN	2.54e-04	10	71	2	EFO_0801358
Disease	Tonic-Clonic Epilepsy	CYP2D6 BCHE	2.54e-04	10	71	2	C0014549
Disease	cholesteryl esters to total lipids in large VLDL percentage	TDRD15 SERPINA1 JMJD1C	3.38e-04	56	71	3	EFO_0022250
Disease	Centriacinar Emphysema	SERPINA1 MMP12	3.71e-04	12	71	2	C0221227
Disease	Panacinar Emphysema	SERPINA1 MMP12	3.71e-04	12	71	2	C0264393
Disease	Focal Emphysema	SERPINA1 MMP12	3.71e-04	12	71	2	C2350878
Disease	free cholesterol to total lipids in very large VLDL percentage	TDRD15 SERPINA1 JMJD1C	3.94e-04	59	71	3	EFO_0022289
Disease	trimethylamine-N-oxide measurement	RTN4 UBE3C	5.10e-04	14	71	2	EFO_0010541
Disease	Pulmonary Emphysema	SERPINA1 MMP12	7.58e-04	17	71	2	C0034067
Disease	citrate measurement	SERPINA1 POR JMJD1C	9.26e-04	79	71	3	EFO_0010114
Disease	hydrocephalus (implicated_via_orthology)	TMEM67 HYDIN	9.51e-04	19	71	2	DOID:10908 (implicated_via_orthology)
Disease	Drug toxicity	SERPINA1 CYP2D6 BCHE	1.11e-03	84	71	3	C0013221
Disease	Adverse reaction to drug	SERPINA1 CYP2D6 BCHE	1.11e-03	84	71	3	C0041755
Disease	liver fibrosis measurement	TDRD15 CBL JMJD1C	1.18e-03	86	71	3	EFO_0010576
Disease	Liver Cirrhosis	TMEM67 RGN SERPINA1	1.99e-03	103	71	3	C0023890
Disease	Fibrosis, Liver	TMEM67 RGN SERPINA1	2.10e-03	105	71	3	C0239946
Disease	Neurotoxicity Syndromes	GABRR2 BCHE	2.22e-03	29	71	2	C0235032
Disease	Encephalopathy, Toxic	GABRR2 BCHE	2.22e-03	29	71	2	C0149504
Disease	Toxic Encephalitis	GABRR2 BCHE	2.22e-03	29	71	2	C0154659
Disease	gallstones	SERPINA1 POC1B JMJD1C	2.27e-03	108	71	3	EFO_0004210
Disease	Familial aplasia of the vermis	TMEM67 POC1B	2.38e-03	30	71	2	C0431399

Protein segments in the cluster

Peptide	Gene	Start	Entry
WAVRVEEKAKFDGIF	EPS15L1	121	Q9UBC2
FPEFEFMWLVDEAKK	ADCK1	211	Q86TW2
FICPALEFTKKFSEW	BCHE	426	P06276
YIFFKGKWERPFEVK	SERPINA1	211	P01009
DPFFSSKVKDWVERL	ACACA	871	Q13085
TIDESPVFKEFVKRW	GLCE	591	O94923
KEWDEFLAKGKRFRV	CHAF1A	666	Q13111
SEWKFKLFRVRSFEK	RAG1	26	P15918
LFRFDVESKEWKERG	RANBP2	1201	P49792
DFVWFLISEEDKKTP	PPP2R3B	376	Q9Y5P8
IFHVNWFRKDKEGKF	PCK1	511	P35558
FKDRFFWLKVSERPK	MMP12	301	P39900
FRWLEVLEKEFDKAF	GOPC	31	Q9HD26
EVIKWTKFFVVFRHP	NOL11	151	Q9H8H0
FKRKAEVVFGDPTEW	OTOA	1006	Q7RTW8
VFFKGDKYWVFKEVT	MMP24	441	Q9Y5R2
DFLKARLWIEFDGEK	NEDD4	986	P46934
WFLFRKKKEEVPEFT	POR	41	P16435
FWKSLTFDKEVKVFE	NCR3LG1	66	Q68D85
KEFWDGFEEVSKRQK	JMJD1C	2236	Q15652
IKQFFVAVEREEWKF	EIF4A3	251	P38919
FWRKFFGDKTIVPWK	CBLB	181	Q13191
FPREGIFKKLFDKWQ	FSIP2	2831	Q5CZC0
LFPKKFISEKWFDVC	MMP21	546	Q8N119
KVVWEKFSSQPKFER	LCT	881	P09848
DFIEQFKIKRPAAWV	HSPA12A	366	O43301
LWIPDKRGKFSEFKA	POC1B	86	Q8TC44
LKEDKFPRFWKEVVE	MYBBP1A	276	Q9BQG0
KKAWFPKITEDFIAT	HTATSF1	56	O43719
VFEIRLSKKEPNFVW	IGSF22	346	Q8N9C0
FKWDIKKFEPHFSIS	HYDIN	4561	Q4G0P3
SVLKDEAVWEKPFRF	CYP2D6	401	P10635
FKPFDGEEWKKVTVT	CNTN1	746	Q12860
EQFREWFLKEFPQVK	APOL3	146	O95236
FIWHPFSIDKEDKEF	HEPHL1	601	Q6MZM0
WFLGRDEAFAIKTKK	KIAA1210	1396	Q9ULL0
RKAFGEKTIVPWKSF	CBL	191	P22681
TFRPLFFKLFDWAKT	HEATR1	1911	Q9H583
FFKLFDWAKTEDAPK	HEATR1	1916	Q9H583
LEFDEFKVFWDKLKQ	CAPN9	581	O14815
DGRLVKKIWVPDVFF	GABRR2	126	P28476
FEVKFEVSKWENPRV	OAS3	856	Q9Y6K5
VFFIDWERPKGKVLK	TMEM67	636	Q5HYA8
FEDWVKTFELFRGKS	FER1L6	1291	Q2WGJ9
DLIFWRDVKKTGFVF	RTN3	846	O95197
DFKPFERVWEVKDSK	RTN4	386	Q9NQC3
TGEWFFEEKAKRFKQ	SYTL5	116	Q8TDW5
FWSRFRKEKEPVVVE	MRPL50	26	Q8N5N7
EKSFDRKTPTFLEIW	PRUNE2	1611	Q8WUY3
WSEEAKIFFRDFLSK	TDRD15	1861	B5MCY1
ETPIFKQFFKDWRDK	SCIN	336	Q9Y6U3
KEIKWFAVLEFDPES	SAMD9L	436	Q8IVG5
LKEIKWFAVLEFDPE	SAMD9	431	Q5K651
FGPFESRRVAKWEKE	PRDM15	441	P57071
WKKIEEGIEFVKHFR	PPWD1	116	Q96BP3
EDVKKQPFFRTLGWE	PKN1	866	Q16512
FVDIPAKKVCRWDSF	RGN	31	Q15493
FVRIGKWFVKPYEKD	MED13	136	Q9UHV7
ETKPEFLKWFVVLEE	ARHGAP35	371	Q9NRY4
LQEEFVKWKGSLFFR	NCAPD3	1006	P42695
QFKEKFPSKHFSWED	TRPM5	281	Q9NZQ8
WGFKKFIRRDFLLDE	SPOPL	131	Q6IQ16
WGFKKFIRRDFLLDE	SPOP	131	O43791
FKGFPDWKSFQREEE	SPATA31D1	76	Q6ZQQ2
EKEFVDFWEKIFQKF	SYCP2	1436	Q9BX26
QSEDKKWFTPREFEI	SP100	631	P23497
AREKLSAFVRKFPFW	ZBED8	401	Q8IZ13
SAFVRKFPFWQKRIE	ZBED8	406	Q8IZ13
TETFFKEFWEQKPLL	RIOX2	51	Q8IUF8
FKDVFVDFTREEWKL	ZNF10	16	P21506
SQFFVEEWRKFVRKP	USP48	746	Q86UV5
LKDKSPVFQFFDWVL	SLC14A2	571	Q15849
QKDFWDFKDKRRFPK	WDR87	2691	Q6ZQQ6
KTFREWDFDLKKLPN	TMA16	141	Q96EY4
FWRVVEGFTDEEKRK	UBE3C	996	Q15386
SSWRKKILPESFFKE	WWTR1	41	Q9GZV5
DIFPKLKLWEFFQVD	AGL	291	P35573