Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainPID_Shc-like

SHC1 SHC3

7.21e-064212IPR006019
DomainSH2

SHC1 LCP2 SHC3

1.90e-04101213PF00017
DomainSH2

SHC1 LCP2 SHC3

2.45e-04110213SM00252
DomainSH2

SHC1 LCP2 SHC3

2.51e-04111213PS50001
DomainSH2

SHC1 LCP2 SHC3

2.58e-04112213IPR000980
Domain-

SHC1 LCP2 SHC3

2.58e-041122133.30.505.10
DomainPID

SHC1 SHC3

4.47e-0428212PF00640
DomainPID

SHC1 SHC3

5.85e-0432212PS01179
DomainPTB

SHC1 SHC3

9.15e-0440212SM00462
DomainPTB/PI_dom

SHC1 SHC3

9.62e-0441212IPR006020
Domain-

WRNIP1 HS3ST3A1 GET3 TJP3

8.78e-037462143.40.50.300
DomainP-loop_NTPase

WRNIP1 HS3ST3A1 GET3 TJP3

1.36e-02848214IPR027417
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PATHWAY_ADAPTOR_PROTEINS

SHC1 SHC3

4.10e-0510142M47930
PathwayREACTOME_SIGNALLING_TO_RAS

SHC1 SHC3

6.01e-0512142MM14657
PathwayREACTOME_SIGNALLING_TO_RAS

SHC1 SHC3

1.72e-0420142M12256
PathwayREACTOME_SIGNALLING_TO_ERKS

SHC1 SHC3

2.94e-0426142MM14716
PathwayKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

SHC1 LCP2 SHC3

3.02e-04137143M5669
PathwayREACTOME_DAP12_SIGNALING

SHC1 LCP2

3.66e-0429142M27171
PathwayREACTOME_DAP12_SIGNALING

SHC1 LCP2

4.19e-0431142MM14886
PathwayREACTOME_SIGNALLING_TO_ERKS

SHC1 SHC3

5.05e-0434142M13881
PathwayREACTOME_RET_SIGNALING

SHC1 SHC3

6.31e-0438142MM15493
PathwayREACTOME_RET_SIGNALING

SHC1 SHC3

6.99e-0440142M27746
PathwayREACTOME_DAP12_INTERACTIONS

SHC1 LCP2

9.25e-0446142M27151
PathwayPID_CD8_TCR_PATHWAY

SHC1 LCP2

1.23e-0353142M88
PathwayREACTOME_DAP12_INTERACTIONS

SHC1 LCP2

1.27e-0354142MM14871
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

SHC1 LCP2

1.47e-0358142MM14914
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

SHC1 LCP2

1.57e-0360142MM14913
PathwayPID_FCER1_PATHWAY

SHC1 LCP2

1.57e-0360142M7
PathwayPID_TRKR_PATHWAY

SHC1 SHC3

1.62e-0361142M187
PathwayREACTOME_SIGNALING_BY_NTRK1_TRKA

SHC1 SHC3

1.73e-0363142MM14714
PathwayPID_TCR_PATHWAY

SHC1 LCP2

1.78e-0364142M34
PathwayKEGG_GLIOMA

SHC1 SHC3

1.84e-0365142M1835
PathwayKEGG_CHRONIC_MYELOID_LEUKEMIA

SHC1 SHC3

2.31e-0373142M321
PathwayREACTOME_SIGNALING_BY_NTRKS

SHC1 SHC3

2.44e-0375142MM14652
PathwayWP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE

SHC1 SHC3

3.05e-0384142M39839
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

SHC1 LCP2

3.19e-0386142M27206
PathwayKEGG_ERBB_SIGNALING_PATHWAY

SHC1 SHC3

3.27e-0387142M12467
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

SHC1 LCP2

3.27e-0387142M27205
Pubmed

[A variety of functions of conventional and neuronal Shc adapter molecules in phosphotyrosine-mediated signalings].

SHC1 SHC3

3.47e-07221211831027
Pubmed

Evolution of Shc functions from nematode to human.

SHC1 SHC3

1.04e-06321211088019
Pubmed

Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development.

SHC1 SHC3

2.08e-06421221117147
Pubmed

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.

SHC1 SHC3

2.08e-06421211877420
Pubmed

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.

SHC1 SHC3

2.08e-0642121623525
Pubmed

SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling.

SHC1 LCP2

3.47e-0652129716598
Pubmed

Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling.

SHC1 LCP2

5.20e-06621210477741
Pubmed

A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.

SHC1 SHC3

5.20e-0662128610109
Pubmed

Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression.

SHC1 SHC3

5.20e-06621220442398
Pubmed

Insulin-stimulated disassociation of the SOS-Grb2 complex.

SHC1 SHC3

5.20e-0662127739560
Pubmed

The structural basis of the activation of Ras by Sos.

SHC1 SHC3

7.28e-0672129690470
Pubmed

Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum.

SHC1 SHC3

7.28e-0672129325171
Pubmed

Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor.

SHC1 SHC3

1.25e-05921215716419
Pubmed

The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.

SHC1 SHC3

1.25e-05921211163269
Pubmed

Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.

SHC1 LCP2 SHC3

1.35e-057721322973453
Pubmed

HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.

SHC1 SHC3

2.28e-051221216436505
Pubmed

Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.

SHC1 SHC3

2.28e-051221212446789
Pubmed

Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135.

SHC1 SHC3

3.15e-051421211409899
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

TCF25 LMTK2 UNC13A

3.32e-0510421310470851
Pubmed

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.

SHC1 LCP2

3.63e-051521210790433
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

SHC1 LCP2 TCF25 SHC3 GET3 NEUROD2

4.02e-05112421621900206
Pubmed

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

SHC1 LCP2 SNX9

7.07e-0513421324658140
Pubmed

In silico prediction of physical protein interactions and characterization of interactome orphans.

SHC1 LCP2 SNX9

7.39e-0513621325402006
Pubmed

Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.

SHC1 SHC3

9.51e-052421220624904
Pubmed

Nerve growth factor signaling, neuroprotection, and neural repair.

SHC1 SHC3

1.12e-042621211520933
Pubmed

Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.

LSP1 GET3

2.04e-043521215188402
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

WRNIP1 TCF25 SNX9 PRMT3

3.20e-0456021435241646
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

SHC1 WRNIP1 TCF25 PRMT3 TJP3

3.20e-04103821526673895
Pubmed

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.

POLI TCF25 SNX9

3.48e-0423021329513927
Pubmed

Substrate-trapping techniques in the identification of cellular PTP targets.

SHC1 LCP2

4.01e-044921215588985
Pubmed

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

SNX9 TJP3

4.18e-045021219807924
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SHC1 LMTK2 SEMA4F PRRC2B TJP3

4.27e-04110521535748872
Pubmed

Next-generation sequencing to generate interactome datasets.

LCP2 POLI TCF25 PRRC2B GET3

5.06e-04114721521516116
GeneFamilySH2 domain containing

SHC1 LCP2 SHC3

8.99e-05101163741
CoexpressionGSE17721_POLYIC_VS_PAM3CSK4_4H_BMDC_DN

SHC1 WRNIP1 LCP2 CREBZF

1.78e-05200214M3833
ToppCellE18.5-Immune-Immune_Myeloid-DC-cDC2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LMTK2 SNX9 LSP1

6.47e-0516821393b7138f17aa14a6398c9b4ea7237781a0e19a66
ToppCellE18.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LMTK2 SNX9 LSP1

6.47e-05168213e393553208617a023f1646169c892a87c95db3f5
ToppCellfacs-MAT-Fat-18m-Lymphocytic-T_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 SEMA4F TJP3

7.06e-0517321397391a763c17ce0107c9e2386e88c417ac75a72e
ToppCellfacs-Kidney-nan-18m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 SEMA4F LSP1

7.31e-0517521384d91843b34504636d5af6bda9930031409a1627
ToppCellfacs-Kidney-nan-18m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 SEMA4F LSP1

7.31e-051752132368aa8318ab83e0e0fd539a17264f9e1d755cf1
ToppCellfacs-SCAT-Fat-18m-Lymphocytic-NK_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 SEMA4F TJP3

7.56e-05177213be35bb178fbc149f8a12984c012d98b486325ba9
ToppCellfacs-Heart-RA-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 SNX9 GET3

7.68e-05178213b505e2550860e777535ee95f29c936242fd607f1
ToppCellDendritic_Cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

LCP2 SNX9 LSP1

7.68e-051782133a28103cf282cc3637d1875a3b4cd7ddf3207687
ToppCelldroplet-Tongue-nan-24m-Myeloid-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 SEMA4F LSP1

7.81e-051792131b079d80f789473701c781f3431ad306e9766797
ToppCell10x5'|World / Manually curated celltypes from each tissue

LCP2 SNX9 LSP1

1.01e-04195213de28b998793271c4f69ce9e183c3e62d809e9cc8
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Ngfr_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HDGFL1 TJP3

6.74e-04822121ed7d7f70f00d6e280cd59c54e710bb724c8b50b
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Ngfr_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HDGFL1 TJP3

6.74e-0482212a5d3c5b7012d8ca7418670242d22aad3ed8c5191
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HDGFL1 TJP3

6.74e-0482212cefd8c6f60ef27fb8823faddca1cf8bbd636f474
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Hpcal1-Tpbg_(Entorhinal_cortex)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

LSP1 SHC3

7.07e-0484212a087403869ee4275cb1fa4e9b0b16426dcf72a31
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Hpcal1-Tpbg_(Entorhinal_cortex)|Hippocampus / BrainAtlas - Mouse McCarroll V32

LSP1 SHC3

7.07e-0484212171fc90fb0d430ebf0a040c54f083aebb0e2b390
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Slc17a7.Cplx3_(Cortical_subplate)|Striatum / BrainAtlas - Mouse McCarroll V32

LSP1 NEUROD2

1.08e-0310421259e982b521610af0532c63b2caf934fa65644b0b
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Slc17a7.Cplx3_(Cortical_subplate)--|Striatum / BrainAtlas - Mouse McCarroll V32

LSP1 NEUROD2

1.08e-031042127642c6ac1a51b431a8d48d35520930c072a3710e
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Slc17a7.Cplx3_(Cortical_subplate)-|Striatum / BrainAtlas - Mouse McCarroll V32

LSP1 NEUROD2

1.08e-03104212016704f1d1c43e6d4067ad1d81c22cc660e605d0
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LCP2 LSP1

1.53e-0312421280526f503e1477b9455d10f27f7e6b56caea3a66
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LCP2 LSP1

1.68e-03130212793c42602dde22da0715a5304ea70d791fdd5354
ToppCellhealthy_donor-Lymphocytic-T_cell-CD4+_T_cell_(ISG_high)|healthy_donor / Disease condition, Lineage, Cell class and subclass

DIXDC1 PRMT3

1.89e-0313821297f5dc17522462133e582b508ad0ef036e656872
ToppCellMild/Remission-B_naive-13|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

DIXDC1 TJP3

2.08e-031452127827aef87f834cd0d19780417757c9386e19b22e
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-regulatory_T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HS3ST3A1 PRRC2B

2.11e-031462127748277cf2f12e2930d4f5a22247ab9bc266a954
ToppCellfacs-Skin-nan-18m-Myeloid-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 SEMA4F

2.20e-0314921223a1b95c12f2e3708dc003e13fab423e89821f11
ToppCellfacs-Skin-nan-18m-Myeloid|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 SEMA4F

2.20e-03149212bb18a18b891af85849b9658d774053f839c9a8e1
ToppCellPND01-03-samps-Myeloid-Granulocyte|PND01-03-samps / Age Group, Lineage, Cell class and subclass

LCP2 LSP1

2.20e-031492127bdb396de8a1ef27ab0c2aaf1452576f4b0b5561
ToppCellfacs-Skin-nan-18m-Myeloid-macrophage|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 SEMA4F

2.20e-03149212c53a3226adc8fd0eaaa842b6a96442287580cbe0
ToppCellPND01-03-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative|PND01-03-samps / Age Group, Lineage, Cell class and subclass

LCP2 LSP1

2.20e-0314921250f53018e525b3d252caa8bed9e075b1bb1086dd
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

LSP1 NEUROD2

2.22e-031502129d5bbdca19da60e1a2121ef64ec8e1375a5dbf6d
ToppCelldroplet-Lung-nan-3m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.25e-03151212c743dc8758416a4f562d60c8fd2df7e659ab6951
ToppCellwk_15-18-Hematologic-Myeloid-HSC/ELP|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

LCP2 LSP1

2.28e-03152212f2cedf16e826aad763bfee5e46444327482f9a53
ToppCellLymphoid-Lymphoid-T_cells_(Cd4+_Tnaive-Tcm)|Lymphoid / shred on cell class and cell subclass (v4)

LCP2 ERICH1

2.31e-03153212ffb8ac88513e83d3ba01574e60beb5476154372b
ToppCellPND28-Immune-Immune_Myeloid-DC-maDC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LSP1 GET3

2.31e-03153212b03375c54aa701817c0fc2c3fef32b870169e697
ToppCellPND28-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LSP1 GET3

2.31e-0315321218bd770a18e642581a6df144d47184c1ac383713
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

HS3ST3A1 SNX9

2.34e-03154212b16f3139ce50e70a6a2377b1da7d7877b4000ea1
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Cpa6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LSP1 NEUROD2

2.34e-0315421212cbc38bc1f7231c67e1d2d5e86e95bc12e24682
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LSP1 NEUROD2

2.40e-03156212fe383ce3a0c37f7343d7026cb51260a04d4c2829
ToppCellsevere_COVID-19-CD8+_T_naive|severe_COVID-19 / disease group, cell group and cell class (v2)

DIXDC1 TJP3

2.40e-0315621247aa46cdf5af9834f4b890ac6ce5e8d548ee98db
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.40e-0315621239aa3adbee9f04cdc0055487d393edfa515e062b
ToppCellPND07-28-samps-Myeloid-Granulocyte|PND07-28-samps / Age Group, Lineage, Cell class and subclass

LCP2 LSP1

2.40e-031562125e1c5a7c9293b886920739cf766521df7f69726c
ToppCellPND07-28-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative|PND07-28-samps / Age Group, Lineage, Cell class and subclass

LCP2 LSP1

2.40e-03156212166f7b1220eaf8e1149dde260dd85a094855c54f
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.40e-03156212a09e3aefe78d63ad5428ad48c6f83e547eb819f6
ToppCellPND07-28-samps|World / Age Group, Lineage, Cell class and subclass

LCP2 LSP1

2.43e-03157212a2005768a6d268879e3fd6dbd8cf674dc98be587
ToppCellfacs-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LCP2 LSP1

2.46e-03158212121d63b8e2e37107467b170e5b2c798a7dbf6325
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.46e-03158212b1b1e50ddd231dcd10cc8e6bb68b2a5e0bb1450a
ToppCelldroplet-Lung-nan-3m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4F DIXDC1

2.46e-03158212ee8ce3cd202807df692b28bb1a81827d49d73862
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4F LSP1

2.46e-0315821290ca742739a208d457db087655ba3d1c18a9da57
ToppCellE17.5-Hematopoietic|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LCP2 LSP1

2.49e-03159212a5648f731f1a22d1af1be2b0e1b80e29d05bae04
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LCP2 LSP1

2.49e-031592126c0ef40f64d2e35eaae3d0002e3c1f22d1239736
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-CD8+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.49e-03159212776139481f2d3630461b4dabca606ebf6e6f034e
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP2 LSP1

2.49e-03159212dd9059f98eec43adbcc0cd42bb155670f7a3a479
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LCP2 LSP1

2.49e-03159212745a59c33b04620c5329bdd50e74a8e611f2dc55
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.49e-03159212bbb19e2f0b7cee70836fa96dc22f888cbc403d28
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Mast|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP2 HS3ST3A1

2.52e-031602126393e3d5c5c8176c93aecd89b313bd054a00d474
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.52e-03160212c0f37057ff073c0578c5236ab5b5f4c9fe2d6224
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP2 UNC13A

2.52e-03160212b2d8940ea8c068273b7da1589d3d6ae5110d8209
ToppCellfacs-Lung-18m-Hematologic-myeloid-non-classical_monocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LCP2 LSP1

2.52e-03160212bc4a93dc5f37829799c37877e751ff3bc122e4ab
ToppCellE18.5-Immune-Immune_Myeloid-DC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LMTK2 LSP1

2.52e-031602129f1fec2cf565193c73cc3c8a4f0476e57478e3b8
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.52e-031602123a5a7984d9ffcb0fbada02b95ffd7aca091acf30
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP2 UNC13A

2.52e-03160212229841be7b984a00a301cd5d88c11226a90d8a88
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.52e-0316021232a105b99fc565c944672f518d6947dcf9ea8832
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.52e-031602129e238e7cb31070a5b9da73b4bfddde54b969b0fd
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP2 UNC13A

2.52e-0316021299c9ae2041445539fada842e1af01368669bfca0
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4F LSP1

2.52e-031602128dae9b0cf90a09acb196223f45a14680102630b2
ToppCellmetastatic_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|metastatic_Brain / Location, Cell class and cell subclass

SNX9 LSP1

2.52e-03160212bc86c6ba1b7815ab944e1ec9da703f469373b8b1
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Mast-Mast_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP2 HS3ST3A1

2.52e-031602122065938e944eb99478fd8132c2c03adeaee6d447
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP2 UNC13A

2.52e-031602129caab1bb63c7e66c44783852ee75b16bb40fa594
ToppCelldroplet-Lung-nan-3m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS3ST3A1 UNC13A

2.56e-03161212110cc7122e3c9f105a11d811d77c8a8852b9de6c
ToppCellVE-CD8-CD4_Treg|VE / Condition, Cell_class and T cell subcluster

SHC1 TJP3

2.56e-03161212a114f4f75859d9ef900e5146686438d051241429
ToppCelldroplet-Lung-nan-3m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS3ST3A1 UNC13A

2.56e-03161212f1d3287d9cb4e0eec99b3509f5dc4b87ae8c8cc9
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.56e-03161212f5821f551cf5c64c9f75cdb723492c87aac1ece0
ToppCellE17.5-Hematopoietic-Immune|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LCP2 LSP1

2.56e-03161212e3ff08d0b9c686253556c56ee88648206751ef2b
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.56e-0316121258a32a1033f379579697bda1bbf047a088e4a34f
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma|TCGA-Brain / Sample_Type by Project: Shred V9

SHC3 UNC13A

2.56e-031612125f6b2d7f80a8ee16651e304481d2da3fae313824
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.56e-0316121254eda81a570e422b35fcea799e640c7654122969
ToppCellE17.5-Hematopoietic-Immune-immune_cell_unspecified|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LCP2 LSP1

2.56e-0316121230741ca6548db2dfb5cf1faecf0d7412c91d0077
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LMTK2 NEUROD2

2.56e-03161212ba7ce599b173cf81c8323e7c96dc3d57379f1ed6
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DIXDC1 TJP3

2.56e-0316121241a89a3d99a9bd6039a3d881d1d9dcd18bc07f25
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.56e-0316121216f77e7a5444d2f2b210362816cd7a07b9b42af6
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DIXDC1 TJP3

2.56e-03161212c4970501c038ed36de447da70eabff020ad78713
ToppCellfacs-Lung-nan-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.59e-031622123fd6aaf0fbaffc7ab38aa25e46c37ef511e1e704
ToppCellfacs-Lung-nan-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.59e-031622128134f73eb76693f4f1845f643042fdc1e81c274c
ToppCellfacs-Thymus-Thymus_Flowthrough-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.59e-031622127e6d20704d77b28512690f882f9ddbbd9c5c3228
ToppCellfacs-Kidney-nan-24m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.59e-03162212f223ea00cf7fbc25e6d5a946ee1ff05f7d4abb06
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.59e-0316221258fe827198c172eeaa26273b0fad7991a718b0bf
ToppCellfacs-Thymus-Thymus_Flowthrough|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.59e-031622122c193f766f2cefe67682f34325d1de6aed778f49
ToppCelldroplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LCP2 LSP1

2.62e-03163212f6c8db5963ee1f8e0c2996f1aeecd58c00e9b099
ToppCellPND01-Immune|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP2 LSP1

2.62e-0316321298af13bd4257a9da325e1ffe5a254f0f58ca6c4b
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.62e-031632128028636632c168dc50731d0ebecaf88a70daf81d
ToppCellfacs-Lung-Endomucin-24m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.62e-031632120644eb8a66d4e944063125c423de66d2393388b1
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-TRGV2_gdT|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LCP2 LSP1

2.62e-03163212004765e016c5658ee4a8bda4899804303064727b
ToppCellfacs-Lung-Endomucin-24m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.62e-0316321204152557aae230e9587fcc16cbabf1247cc5b419
ToppCellPND01-Immune-Immune_Myeloid|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP2 LSP1

2.62e-03163212ca12d01615be371fe215ec673d4ec787381e0ca6
ToppCellfacs-Lung-3m-Hematologic-myeloid-non-classical_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LCP2 LSP1

2.62e-03163212bbbc3f0ce2616d07136f69ce682ba1d3790711d9
ToppCelldroplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LCP2 LSP1

2.65e-03164212ea2897942ad72fba900c7ab354d6a9e203bf0e4a
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-Ly6g5b+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.65e-031642124e1861382c9e93856da19303474c8975c19706d2
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.65e-0316421215d52666e5150e7c34b1f641a937fb2d5e8aaf8a
ToppCellfacs-Lung-EPCAM-24m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.65e-03164212d622f0d8d8bad48dfdf160ec63c545df192637a9
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.65e-03164212467ad12884b70d243988174ae960ee2b7b6cfb0c
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-mature_NK_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LCP2 LSP1

2.65e-0316421222f37c39fdce2cf6dc72c6db619537d4b0234839
DrugResveratrol [501-36-0]; Down 200; 17.6uM; HL60; HG-U133A

LSP1 PRMT3 PRRC2B CREBZF

2.73e-051942141715_DN
DrugPentoxifylline [6493-05-6]; Down 200; 14.4uM; HL60; HG-U133A

LCP2 POLI LSP1 PRMT3

2.84e-051962141444_DN
DrugReserpinic acid hydrochloride; Up 200; 9.2uM; PC3; HT_HG-U133A

WRNIP1 LMTK2 CREBZF TJP3

2.96e-051982146603_UP
Diseasedisease free survival, response to mepolizumab

LCP2 HS3ST3A1

1.19e-0424202EFO_0000409, EFO_0008459
Diseaseresponse to beta blocker, heart rate

POLI SNX9

6.81e-0457202EFO_0004326, EFO_0007766
Diseasetreatment-resistant hypertension

LSP1 PRMT3

2.46e-03109202EFO_1002006

Protein segments in the cluster

PeptideGeneStartEntry
GWGEQHNDDPDSAVD

UNC13A

181

Q9UPW8
EDGADASEEDPTWAG

ERICH1

296

Q86X53
EEIFHDDDAIPGWEG

DIXDC1

656

Q155Q3
DEEASQEWHAEAPGG

HDGFL1

231

Q5TGJ6
DEEGGGFEWDDDFSP

LMTK2

1411

Q8IWU2
DDGEEAAWEEESPGL

HS3ST3A1

106

Q9Y663
AAWEDEDDADLPHGK

PRMT3

31

O60678
EAPELDEDEGFGDWS

LSP1

71

P33241
AGWGVEAEEFEDAPD

GET3

6

O43681
EGGGDDDEEDAEAWA

POLI

11

Q9UNA4
GPATGDDDDWDEDWD

SNX9

156

Q9Y5X1
VALSPAEWGDEDGDD

SEMA4F

231

O95754
DEPWTEEEGDGSDHP

SHC3

326

Q92529
GLWRGDDDDEAAAAE

CREBZF

141

Q9NS37
ADADDGWAGLHEEVD

PRRC2B

366

Q5JSZ5
GDADADGEDDPGHWD

WRNIP1

176

Q96S55
DGEDDPGHWDADAAE

WRNIP1

181

Q96S55
HDAESSDEDGYDWGP

TJP3

901

O95049
LEAPHEDDAEGEGEW

TCF25

661

Q9BQ70
GFDGSAWDEEEEEPP

SHC1

331

P29353
FPEETESHEEDNGGW

LCP2

91

Q13094
WGDGEDDEPRSDKGD

NEUROD2

21

Q15784