Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin binding	DIAPH1 DIAPH2 ESPN FMNL3 FMN2 INF2 PHACTR3	6.67e-05	479	43	7	GO:0003779
GeneOntologyBiologicalProcess	actin cytoskeleton organization	TAOK2 SHANK1 DIAPH1 DIAPH2 ESPN FMNL3 FMN2 CAVIN3 INF2 PHACTR3	4.51e-06	803	43	10	GO:0030036
GeneOntologyBiologicalProcess	actin filament-based process	TAOK2 SHANK1 DIAPH1 DIAPH2 ESPN FMNL3 FMN2 CAVIN3 INF2 PHACTR3	1.38e-05	912	43	10	GO:0030029
GeneOntologyBiologicalProcess	neuron projection retraction	DIAPH1 DIAPH2	2.54e-05	4	43	2	GO:0106028
GeneOntologyBiologicalProcess	multicellular organismal locomotion	DIAPH1 DIAPH2	2.54e-05	4	43	2	GO:0071965
GeneOntologyBiologicalProcess	hematopoietic stem cell homeostasis	TCIRG1 UBAP2L GLIS2	4.83e-05	34	43	3	GO:0061484
GeneOntologyBiologicalProcess	axon midline choice point recognition	DIAPH1 DIAPH2	8.86e-05	7	43	2	GO:0016199
GeneOntologyBiologicalProcess	parallel actin filament bundle assembly	ESPN FMN2	8.86e-05	7	43	2	GO:0030046
GeneOntologyBiologicalProcess	axon choice point recognition	DIAPH1 DIAPH2	1.51e-04	9	43	2	GO:0016198
GeneOntologyBiologicalProcess	actin nucleation	DIAPH1 FMN2 INF2	3.37e-04	65	43	3	GO:0045010
GeneOntologyCellularComponent	actin filament	DIAPH1 DIAPH2 ESPN FMN2 INF2	1.07e-05	146	42	5	GO:0005884
Domain	FH2	DIAPH1 DIAPH2 FMNL3 FMN2 INF2	1.50e-10	15	43	5	PS51444
Domain	FH2_Formin	DIAPH1 DIAPH2 FMNL3 FMN2 INF2	1.50e-10	15	43	5	IPR015425
Domain	FH2	DIAPH1 DIAPH2 FMNL3 FMN2 INF2	1.50e-10	15	43	5	PF02181
Domain	FH2	DIAPH1 DIAPH2 FMNL3 FMN2 INF2	1.50e-10	15	43	5	SM00498
Domain	Drf_GBD	DIAPH1 DIAPH2 FMNL3 INF2	3.04e-09	9	43	4	PF06371
Domain	FH3_dom	DIAPH1 DIAPH2 FMNL3 INF2	3.04e-09	9	43	4	IPR010472
Domain	GTPase-bd	DIAPH1 DIAPH2 FMNL3 INF2	3.04e-09	9	43	4	IPR010473
Domain	Drf_FH3	DIAPH1 DIAPH2 FMNL3 INF2	3.04e-09	9	43	4	PF06367
Domain	Drf_FH3	DIAPH1 DIAPH2 FMNL3 INF2	3.04e-09	9	43	4	SM01139
Domain	Drf_GBD	DIAPH1 DIAPH2 FMNL3 INF2	3.04e-09	9	43	4	SM01140
Domain	GBD/FH3_dom	DIAPH1 DIAPH2 FMNL3 INF2	7.94e-09	11	43	4	IPR014768
Domain	GBD_FH3	DIAPH1 DIAPH2 FMNL3 INF2	7.94e-09	11	43	4	PS51232
Domain	Drf_FH1	DIAPH1 FMN2	5.18e-06	2	43	2	PF06346
Domain	Formin_homology_1	DIAPH1 FMN2	5.18e-06	2	43	2	IPR009408
Domain	Drf_DAD	DIAPH1 DIAPH2	1.55e-05	3	43	2	IPR010465
Domain	Drf_DAD	DIAPH1 DIAPH2	1.55e-05	3	43	2	PF06345
Domain	DAD_dom	DIAPH1 DIAPH2	1.44e-04	8	43	2	IPR014767
Domain	DAD	DIAPH1 DIAPH2	1.44e-04	8	43	2	PS51231
Domain	UBA-like	TNRC6B DMRTA2 UBAP2L	4.29e-04	64	43	3	IPR009060
Domain	WH2	ESPN INF2	4.63e-04	14	43	2	SM00246
Domain	SAM_1	SHANK1 SAMD1 CASKIN1	5.13e-04	68	43	3	PF00536
Domain	WH2	ESPN INF2	6.09e-04	16	43	2	PF02205
Domain	WH2_dom	ESPN INF2	1.06e-03	21	43	2	IPR003124
Domain	SAM	SHANK1 SAMD1 CASKIN1	1.09e-03	88	43	3	SM00454
Domain	EPHD	BRPF3 KMT2D	1.16e-03	22	43	2	PS51805
Domain	SAM_DOMAIN	SHANK1 SAMD1 CASKIN1	1.36e-03	95	43	3	PS50105
Domain	WH2	ESPN INF2	1.38e-03	24	43	2	PS51082
Domain	SAM	SHANK1 SAMD1 CASKIN1	1.44e-03	97	43	3	IPR001660
Domain	Ank_2	SHANK1 ESPN PPP1R13B CASKIN1	1.48e-03	215	43	4	PF12796
Domain	SH3	SHANK1 PPP1R13B FYB2 CASKIN1	1.51e-03	216	43	4	SM00326
Domain	SH3_domain	SHANK1 PPP1R13B FYB2 CASKIN1	1.61e-03	220	43	4	IPR001452
Domain	Ank	SHANK1 ESPN PPP1R13B CASKIN1	1.84e-03	228	43	4	PF00023
Domain	-	SHANK1 SAMD1 CASKIN1	1.86e-03	106	43	3	1.10.150.50
Domain	SAM/pointed	SHANK1 SAMD1 CASKIN1	2.46e-03	117	43	3	IPR013761
Domain	-	SHANK1 ESPN PPP1R13B CASKIN1	2.49e-03	248	43	4	1.25.40.20
Domain	ANK	SHANK1 ESPN PPP1R13B CASKIN1	2.60e-03	251	43	4	SM00248
Domain	ANK_REPEAT	SHANK1 ESPN PPP1R13B CASKIN1	2.68e-03	253	43	4	PS50088
Domain	Ankyrin_rpt-contain_dom	SHANK1 ESPN PPP1R13B CASKIN1	2.72e-03	254	43	4	IPR020683
Domain	ANK_REP_REGION	SHANK1 ESPN PPP1R13B CASKIN1	2.72e-03	254	43	4	PS50297
Domain	Ankyrin_rpt	SHANK1 ESPN PPP1R13B CASKIN1	3.04e-03	262	43	4	IPR002110
Domain	-	ZC3H6 ZC3H4	3.82e-03	40	43	2	4.10.1000.10
Domain	Znf_FYVE_PHD	BRPF3 KMT2D ZBTB4	4.68e-03	147	43	3	IPR011011
Domain	ZnF_C3H1	ZC3H6 ZC3H4	5.46e-03	48	43	2	SM00356
Domain	zf-CCCH	ZC3H6 ZC3H4	5.69e-03	49	43	2	PF00642
Domain	ARM-type_fold	DIAPH1 DIAPH2 FMNL3 INF2	7.54e-03	339	43	4	IPR016024
Domain	Znf_CCCH	ZC3H6 ZC3H4	7.89e-03	58	43	2	IPR000571
Domain	ZF_C3H1	ZC3H6 ZC3H4	7.89e-03	58	43	2	PS50103
Pubmed	Expression of multiple formins in adult tissues and during developmental stages of mouse brain.	DIAPH1 DIAPH2 FMNL3 FMN2 INF2	5.09e-12	14	44	5	26272686
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TAOK2 STRN4 SHANK1 DIAPH1 DIAPH2 TNRC6B LMTK3 UBAP2L ZC3H4 PRRC2A ATF6B CASKIN1	1.77e-09	963	44	12	28671696
Pubmed	Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2).	DIAPH1 DIAPH2 INF2	7.55e-09	4	44	3	21278336
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TAOK2 SAMD1 KMT2D PRCC ZC3H4 ZCCHC8 SF3A2	2.30e-07	341	44	7	32971831
Pubmed	Functional proteomics mapping of a human signaling pathway.	DAB2 DIAPH1 FMNL3 PPP1R13B KMT2D ZCCHC8 SF3A2 PHACTR3	6.86e-07	591	44	8	15231748
Pubmed	mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.	DIAPH1 DIAPH2	1.56e-06	2	44	2	30256801
Pubmed	Coordination of microtubule acetylation and the actin cytoskeleton by formins.	FMN2 INF2	1.56e-06	2	44	2	29947928
Pubmed	Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis.	GLIS1 GLIS2	1.56e-06	2	44	2	11741991
Pubmed	The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization.	DIAPH1 DIAPH2	1.56e-06	2	44	2	14992721
Pubmed	Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.	DIAPH1 DIAPH2	1.56e-06	2	44	2	30808751
Pubmed	Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport.	DIAPH1 DIAPH2	1.56e-06	2	44	2	28760985
Pubmed	Diaphanous 1 and 2 regulate smooth muscle cell differentiation by activating the myocardin-related transcription factors.	DIAPH1 DIAPH2	1.56e-06	2	44	2	17170370
Pubmed	Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.	DIAPH1 DIAPH2	1.56e-06	2	44	2	21980468
Pubmed	Mechanisms of actin filament severing and elongation by formins.	DIAPH1 INF2	1.56e-06	2	44	2	38843827
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	FMN2 TNRC6B HDAC5 LMTK3 UBAP2L PRRC2A CASKIN1	2.10e-06	475	44	7	31040226
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	DIAPH1 FMN2 INF2 PRCC ZC3H4 ZCCHC8 SF3A2	3.18e-06	506	44	7	30890647
Pubmed	Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules.	DIAPH1 INF2	4.69e-06	3	44	2	21998204
Pubmed	Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling.	DIAPH2 INF2	4.69e-06	3	44	2	23620398
Pubmed	Unique transgenic animal model for hereditary hearing loss.	DIAPH1 ESPN	4.69e-06	3	44	2	19102128
Pubmed	mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety.	DIAPH1 DIAPH2	4.69e-06	3	44	2	27880913
Pubmed	GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions.	GLIS1 GLIS2	4.69e-06	3	44	2	14500813
Pubmed	Essential and nonredundant roles for Diaphanous formins in cortical microtubule capture and directed cell migration.	DIAPH1 DIAPH2	4.69e-06	3	44	2	24403606
Pubmed	Gene of the month: GLIS1-3.	GLIS1 GLIS2	4.69e-06	3	44	2	32699115
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	STRN4 FMN2 LMTK3 UBAP2L PRRC2A CASKIN1	4.84e-06	347	44	6	17114649
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	STRN4 PPP1R13B TNRC6B KMT2D ZNF598 UBAP2L PRRC2A	5.43e-06	549	44	7	38280479
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DIAPH1 FMN2 TNRC6B SAMD1 BRPF3 NCKAP5L ZC3H4 ZCCHC8 SH3BP2	9.00e-06	1116	44	9	31753913
Pubmed	Metastasis suppressor microRNA-335 targets the formin family of actin nucleators.	FMNL3 FMN2	9.37e-06	4	44	2	24223803
Pubmed	Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis.	DIAPH1 DIAPH2	9.37e-06	4	44	2	24239357
Pubmed	EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination.	DIAPH1 DIAPH2	9.37e-06	4	44	2	23890216
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	DAB2 SAMD1 PRRC2A SH3BP2	1.08e-05	108	44	4	19531213
Pubmed	RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.	DIAPH1 DIAPH2	1.56e-05	5	44	2	23034183
Pubmed	mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.	DIAPH1 DIAPH2	1.56e-05	5	44	2	31911947
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	STRN4 PPP1R13B TNRC6B HDAC5 NCKAP5L ZCCHC8	2.01e-05	446	44	6	24255178
Pubmed	Specificity of interactions between mDia isoforms and Rho proteins.	DIAPH1 DIAPH2	2.34e-05	6	44	2	18829452
Pubmed	The NECAP PHear domain increases clathrin accessory protein binding potential.	DAB2 NECAP1	2.34e-05	6	44	2	17762867
Pubmed	EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration.	DIAPH1 DIAPH2	2.34e-05	6	44	2	15311282
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	DAB2 CAVIN3 HDAC5 NCKAP5L UBAP2L PRCC ZCCHC8 SH3BP2	4.18e-05	1038	44	8	26673895
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	DIAPH1 DIAPH2 UBAP2L SF3A2	4.37e-05	154	44	4	16055720
Pubmed	Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.	ESPN KMT2D	5.60e-05	9	44	2	35296311
Pubmed	Cdc42 and mDia3 regulate microtubule attachment to kinetochores.	DIAPH1 DIAPH2	6.99e-05	10	44	2	15085137
Pubmed	Protein phosphatase 1α interacting proteins in the human brain.	PRR16 PPP1R13B PHACTR3	8.55e-05	67	44	3	22321011
Pubmed	A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.	DIAPH1 DIAPH2	1.02e-04	12	44	2	22246438
Pubmed	Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.	STRN4 SAMD1 HDAC5 SF3A2	1.32e-04	205	44	4	27976729
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	STRN4 UBAP2L ZC3H4 PRRC2A SF3A2	1.46e-04	399	44	5	35987950
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	TNRC6B ZNF598 UBAP2L PRCC ZC3H4 PRRC2A ZCCHC8	1.59e-04	934	44	7	33916271
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	PPP1R13B TNRC6B ZNF598 NCKAP5L	1.67e-04	218	44	4	33378226
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	DIAPH1 ZNF598 PRRC2A SF3A2	1.73e-04	220	44	4	24550385
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TNRC6B SAMD1 KMT2D HDAC5 ZCCHC8	1.81e-04	418	44	5	34709266
Pubmed	Genetic loci that control the angiogenic response to basic fibroblast growth factor.	MMP16 ZC3H4	1.86e-04	16	44	2	15226265
Pubmed	The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.	TNRC6B UBAP2L PRRC2A	2.56e-04	97	44	3	37151849
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	TAOK2 SHANK1 DIAPH1 CASKIN1	2.87e-04	251	44	4	27507650
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	SHANK1 TNRC6B UBAP2L PRRC2A ZCCHC8	2.87e-04	462	44	5	31138677
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	TNRC6B ZNF598 UBAP2L ZC3H4 PRRC2A NECAP1	2.87e-04	724	44	6	36232890
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KMT2D HDAC5 UBAP2L ZC3H4 ZCCHC8	3.07e-04	469	44	5	27634302
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	DIAPH1 DIAPH2 PRRC2A	3.15e-04	104	44	3	31240132
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	DAB2 TNRC6B PRCC ZC3H4 NECAP1	3.16e-04	472	44	5	38943005
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	TNRC6B ZNF598 UBAP2L	3.42e-04	107	44	3	30995489
Pubmed	A human MAP kinase interactome.	SHANK1 DAB2 DIAPH2 PPP1R13B NCKAP5L	3.62e-04	486	44	5	20936779
Pubmed	Human transcription factor protein interaction networks.	PPP1R13B TNRC6B KMT2D HDAC5 MRPL22 UBAP2L PRCC PRRC2A	3.77e-04	1429	44	8	35140242
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DAB2 KMT2D UBAP2L ZC3H4 PRRC2A ZCCHC8	4.09e-04	774	44	6	15302935
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	DAB2 UBAP2L ZC3H4 PRRC2A ZCCHC8	4.23e-04	503	44	5	16964243
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 STRN4 DIAPH2 KMT2D INF2 CASKIN1 ZBTB4	4.40e-04	1105	44	7	35748872
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ESPN TNRC6B ACVR2B MMP16 INF2 UBAP2L GLIS1 SH3BP2	4.96e-04	1489	44	8	28611215
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ZNF598 MRPL22 UBAP2L ZC3H4 PRRC2A SF3A2	5.10e-04	807	44	6	22681889
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TAOK2 STRN4 TNRC6B SAMD1 ZNF598 PRRC2A ZCCHC8 SF3A2	5.14e-04	1497	44	8	31527615
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TAOK2 FMNL3 BRPF3 ZC3H4 CASKIN1	5.32e-04	529	44	5	14621295
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	STRN4 DAB2 FMNL3	5.39e-04	125	44	3	29467281
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	TNRC6B ZNF598 NCKAP5L PRRC2A	5.75e-04	302	44	4	30561431
Pubmed	TERRA transcripts are bound by a complex array of RNA-binding proteins.	UBAP2L PRRC2A	5.79e-04	28	44	2	20975687
Pubmed	Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.	DIAPH1 FMNL3	6.21e-04	29	44	2	21834987
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	DIAPH1 PPP1R13B HDAC5 NCKAP5L ZCCHC8	8.56e-04	588	44	5	38580884
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	DIAPH1 TNRC6B ZNF598 INF2 ZC3H6 PRRC2A SF3A2	8.99e-04	1247	44	7	27684187
Pubmed	STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.	DAB2 SF3A2	9.59e-04	36	44	2	33230114
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	TAOK2 ZC3H4 PRRC2A	1.08e-03	159	44	3	30581152
Interaction	ZFP36 interactions	PPP1R13B TNRC6B ZNF598 NCKAP5L UBAP2L PRRC2A	1.94e-06	181	42	6	int:ZFP36
Interaction	MEX3B interactions	PPP1R13B TNRC6B ZNF598 NCKAP5L UBAP2L PRRC2A	6.29e-06	222	42	6	int:MEX3B
Interaction	FHDC1 interactions	DIAPH1 DIAPH2 FMNL3	6.72e-06	18	42	3	int:FHDC1
Interaction	FXR1 interactions	SHANK1 TNRC6B SAMD1 HDAC5 LMTK3 ZNF598 UBAP2L PRRC2A ATF6B	8.73e-06	679	42	9	int:FXR1
Interaction	PRMT2 interactions	SHANK1 ESPN SAMD1 PRRC2A	3.82e-05	91	42	4	int:PRMT2
Interaction	DAAM2 interactions	DIAPH1 DIAPH2 FMNL3	6.75e-05	38	42	3	int:DAAM2
Interaction	PHF21A interactions	TNRC6B SAMD1 KMT2D HDAC5 NCKAP5L ZCCHC8	7.28e-05	343	42	6	int:PHF21A
Interaction	FMNL1 interactions	DIAPH1 DIAPH2 FMNL3 HDAC5	7.74e-05	109	42	4	int:FMNL1
Interaction	ACTC1 interactions	DIAPH1 FMN2 INF2 PRCC ZC3H4 ZCCHC8 SF3A2 PHACTR3	7.95e-05	694	42	8	int:ACTC1
Interaction	PPP1CA interactions	DIAPH1 PRR16 PPP1R13B CAVIN3 HDAC5 INF2 SF3A2 PHACTR3	8.11e-05	696	42	8	int:PPP1CA
Interaction	MAPRE1 interactions	TAOK2 DAB2 DIAPH1 PPP1R13B ZNF598 NCKAP5L PRRC2A	8.38e-05	514	42	7	int:MAPRE1
Interaction	FMR1 interactions	DIAPH2 TNRC6B LMTK3 ZNF598 UBAP2L PRRC2A CASKIN1	1.09e-04	536	42	7	int:FMR1
Interaction	CNOT9 interactions	STRN4 TNRC6B ZNF598 UBAP2L PRRC2A	1.14e-04	231	42	5	int:CNOT9
Interaction	HDAC4 interactions	DIAPH1 FMN2 TNRC6B HDAC5 LMTK3 UBAP2L PRRC2A CASKIN1	1.29e-04	744	42	8	int:HDAC4
Interaction	DIAPH3 interactions	DIAPH1 DIAPH2 FMNL3 FMN2	1.32e-04	125	42	4	int:DIAPH3
Interaction	DVL2 interactions	TAOK2 DAB2 DIAPH1 PPP1R13B BRPF3 ZNF598 NECAP1	1.38e-04	557	42	7	int:DVL2
Interaction	ERLEC1 interactions	TCIRG1 ZC3H4 PRRC2A ATF6B	1.44e-04	128	42	4	int:ERLEC1
Interaction	FMNL3 interactions	DIAPH1 DIAPH2 FMNL3	1.45e-04	49	42	3	int:FMNL3
Interaction	EIF4E2 interactions	TNRC6B ZNF598 UBAP2L PRRC2A ZCCHC8	1.53e-04	246	42	5	int:EIF4E2
Interaction	DIS3L interactions	BRPF3 ZNF598 ZCCHC8	1.54e-04	50	42	3	int:DIS3L
Interaction	TOP3B interactions	TAOK2 STRN4 DIAPH2 TNRC6B KMT2D ZNF598 INF2 UBAP2L PRRC2A CASKIN1 ZBTB4	1.55e-04	1470	42	11	int:TOP3B
Interaction	WWTR1 interactions	STRN4 PPP1R13B TNRC6B KMT2D ZNF598 PRRC2A	2.25e-04	422	42	6	int:WWTR1
Interaction	PUM2 interactions	TNRC6B SAMD1 UBAP2L PRRC2A	2.27e-04	144	42	4	int:PUM2
Interaction	ZC3H6 interactions	ZC3H6 ZC3H4	2.30e-04	11	42	2	int:ZC3H6
Interaction	CPEB1 interactions	PPP1R13B TNRC6B UBAP2L PRRC2A	2.39e-04	146	42	4	int:CPEB1
Interaction	REST interactions	STRN4 SAMD1 HDAC5 ZNF598 SF3A2	2.52e-04	274	42	5	int:REST
Interaction	CDC42 interactions	TAOK2 DIAPH1 DIAPH2 FMNL3 PPP1R13B FMN2 NCKAP5L INF2 ZC3H4 SF3A2	3.05e-04	1323	42	10	int:CDC42
Interaction	LATS2 interactions	PPP1R13B TNRC6B NCKAP5L GLIS1 GLIS2	3.23e-04	289	42	5	int:LATS2
Interaction	CNTNAP2 interactions	SHANK1 TNRC6B UBAP2L CASKIN1	3.23e-04	158	42	4	int:CNTNAP2
Interaction	SOWAHB interactions	DIAPH1 DIAPH2	3.26e-04	13	42	2	int:SOWAHB
Interaction	PAN3 interactions	TNRC6B UBAP2L PRRC2A	3.36e-04	65	42	3	int:PAN3
Interaction	VASP interactions	DIAPH1 PPP1R13B FMN2 TNRC6B INF2	3.49e-04	294	42	5	int:VASP
Interaction	UBAP2L interactions	TAOK2 TNRC6B ZNF598 UBAP2L PRRC2A	3.71e-04	298	42	5	int:UBAP2L
Interaction	DIAPH2 interactions	DIAPH1 DIAPH2 FMNL3	3.84e-04	68	42	3	int:DIAPH2
Interaction	DAAM1 interactions	DIAPH1 DIAPH2 FMNL3	4.54e-04	72	42	3	int:DAAM1
Interaction	GIGYF1 interactions	TNRC6B BRPF3 ZNF598 UBAP2L	4.96e-04	177	42	4	int:GIGYF1
Interaction	CNOT2 interactions	TAOK2 TNRC6B UBAP2L PRRC2A	5.07e-04	178	42	4	int:CNOT2
Interaction	SMG7 interactions	TNRC6B KMT2D UBAP2L ZC3H4 PRRC2A	5.07e-04	319	42	5	int:SMG7
Interaction	RCOR1 interactions	TNRC6B SAMD1 KMT2D HDAC5 NCKAP5L ZCCHC8	5.22e-04	494	42	6	int:RCOR1
Interaction	ALG13 interactions	TNRC6B KMT2D UBAP2L PRRC2A	5.62e-04	183	42	4	int:ALG13
Interaction	SDHAP2 interactions	ZC3H4 PRRC2A	5.65e-04	17	42	2	int:SDHAP2
Interaction	SMAP2 interactions	DAB2 TNRC6B UBAP2L PRRC2A	6.35e-04	189	42	4	int:SMAP2
Interaction	SOX3 interactions	GLIS1 GLIS2	6.35e-04	18	42	2	int:SOX3
Interaction	FAM120C interactions	PPP1R13B TNRC6B UBAP2L PRRC2A	6.60e-04	191	42	4	int:FAM120C
Interaction	CAPN13 interactions	ZC3H4 PRRC2A	7.09e-04	19	42	2	int:CAPN13
Interaction	SMG5 interactions	TNRC6B UBAP2L PRRC2A	7.13e-04	84	42	3	int:SMG5
Interaction	CPSF6 interactions	TAOK2 DAB2 UBAP2L ZC3H4 ZCCHC8 SF3A2	7.25e-04	526	42	6	int:CPSF6
Interaction	LRP1 interactions	DAB2 DIAPH1 SAMD1 MMP16	7.27e-04	196	42	4	int:LRP1
Cytoband	12q13.12	FMNL3 KMT2D NCKAP5L	6.77e-06	38	44	3	12q13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr1p32	DMRTA2 GLIS1 FYB2	4.52e-04	155	44	3	chr1p32
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	STRN4 SHANK1 C19orf85 LMTK3 ZC3H4 FGF21	9.19e-04	1192	44	6	chr19q13
Cytoband	1p32.3	DMRTA2 GLIS1	1.58e-03	61	44	2	1p32.3
Cytoband	16p13.3	ZNF598 CASKIN1 GLIS2	1.67e-03	244	44	3	16p13.3
Cytoband	19q13.33	LMTK3 FGF21	4.69e-03	106	44	2	19q13.33
GeneFamily	Sterile alpha motif domain containing	SHANK1 SAMD1 CASKIN1	2.99e-04	88	27	3	760
GeneFamily	Ankyrin repeat domain containing	SHANK1 ESPN PPP1R13B CASKIN1	4.31e-04	242	27	4	403
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6B KMT2D	6.31e-04	25	27	2	775
GeneFamily	Zinc fingers CCCH-type	ZC3H6 ZC3H4	1.24e-03	35	27	2	73
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R13B LMTK3 PHACTR3	2.42e-03	181	27	3	694
GeneFamily	PHD finger proteins	BRPF3 KMT2D	7.93e-03	90	27	2	88
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF598 GLIS1 GLIS2 ZBTB4	2.09e-02	718	27	4	28
Coexpression	GSE16266_CTRL_VS_LPS_STIM_MEF_UP	FMNL3 SAMD1 BRPF3 SH3BP2 ZBTB4	1.78e-05	198	43	5	M7219
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	KMT2D ZNF598 NCKAP5L UBAP2L PRRC2A SH3BP2	1.79e-05	338	43	6	M17094
Coexpression	GSE15930_NAIVE_VS_72H_IN_VITRO_STIM_IL12_CD8_TCELL_UP	STRN4 DIAPH2 PRCC SF3A2 NECAP1	1.87e-05	200	43	5	M3608
Coexpression	GSE5589_UNSTIM_VS_45MIN_LPS_STIM_MACROPHAGE_DN	SHANK1 HDAC5 UBAP2L PRRC2A GLIS1	1.87e-05	200	43	5	M6599
Drug	Sulfaguanidine [57-67-0]; Down 200; 18.6uM; PC3; HG-U133A	STRN4 DAB2 DIAPH1 PPP1R13B ACVR2B SH3BP2	1.87e-06	198	43	6	1913_DN
Drug	Lynestrenol [52-76-6]; Down 200; 14uM; PC3; HG-U133A	TAOK2 STRN4 DIAPH1 ACVR2B UBAP2L SH3BP2	1.98e-06	200	43	6	1953_DN
Disease	autosomal dominant auditory neuropathy 1 (implicated_via_orthology)	DIAPH1 DIAPH2	5.93e-06	3	42	2	DOID:0060690 (implicated_via_orthology)
Disease	Papillary Renal Cell Carcinoma	SHANK1 FMN2 PRCC	8.09e-04	128	42	3	C1306837
Disease	Renal Cell Carcinoma	SHANK1 FMN2 PRCC	8.09e-04	128	42	3	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	SHANK1 FMN2 PRCC	8.09e-04	128	42	3	C1266043
Disease	Chromophobe Renal Cell Carcinoma	SHANK1 FMN2 PRCC	8.09e-04	128	42	3	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	SHANK1 FMN2 PRCC	8.09e-04	128	42	3	C1266044
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	SHANK1 FMN2 PRCC	1.23e-03	148	42	3	C0279702
Disease	bipolar disorder	TAOK2 PPP1R13B KMT2D HDAC5 MMP16	1.32e-03	577	42	5	MONDO_0004985
Disease	grip strength measurement	TNRC6B ZC3H4 PRRC2A GLIS1	1.53e-03	350	42	4	EFO_0006941
Disease	serum non-albumin protein measurement	DAB2 TCIRG1 PRRC2A FGF21	1.71e-03	361	42	4	EFO_0004568
Disease	schizophrenia, anorexia nervosa	PPP1R13B MMP16	2.14e-03	48	42	2	MONDO_0005090, MONDO_0005351
Disease	corpus callosum posterior volume measurement	TNRC6B ZBTB4	2.51e-03	52	42	2	EFO_0010298
Disease	sexual dimorphism measurement	TAOK2 BRPF3 HDAC5 ZC3H4 CASKIN1 ZBTB4	4.53e-03	1106	42	6	EFO_0021796
Disease	diverticular disease	DAB2 TNRC6B ZBTB4	4.61e-03	236	42	3	EFO_0009959

Protein segments in the cluster

Peptide	Gene	Start	Entry
RKGPAAPPPTPVKPP	CAVIN3	196	Q969G5
APPPTPVKPPRLGPG	CAVIN3	201	Q969G5
FTSKGPGPLLPPPPP	SH3BP2	226	P78314
PGPLLPPPPPKHGLP	SH3BP2	231	P78314
KLPPPPTLEPTGPAP	BRPF3	831	Q9ULD4
IPPPPPLPEGVGIPS	DIAPH1	651	O60610
PPPLGGVPPPPGISL	DIAPH2	606	O60879
PGSPLPPPVKPLSPD	DMRTA2	206	Q96SC8
KVPPPIPGVGKQLPP	PPP1R13B	446	Q96KQ4
LVTPPQPPPRAGPPK	DAB2	616	P98082
VPPVPGKPRQVLPPG	CASKIN1	756	Q8WXD9
KTKPPRLDPPPGVPP	NCKAP5L	1146	Q9HCH0
PGVPPARPPPLTKVP	NCKAP5L	1156	Q9HCH0
PRGTIGKPTPPPPPP	ESPN	421	B1AK53
PPDPGPLPLPGPREK	LMTK3	836	Q96Q04
LQKPPPPPPSPFLGV	C19orf85	86	A0A1B0GUS0
PLPGLPPALPEPPGI	FGF21	166	Q9NSA1
LRPPPKPPLPAPDGG	GLIS2	331	Q9BZE0
PPPPPLPSVGAKALP	INF2	441	Q27J81
AKALPTAPPPPPLPG	INF2	451	Q27J81
PGEPPSVPLLLPPGK	FMNL3	11	Q8IVF7
PPGTPPSYKLPLPGP	HDAC5	231	Q9UQL6
PIVSPLKGLGPPPLP	GLIS1	461	Q8NBF1
ILPLPPLPGAGIPPP	FMN2	931	Q9NZ56
GIPPPPLLPVSGPPL	FMN2	1231	Q9NZ56
PSPVPLPPGKPALPG	SAMD1	426	Q6SPF0
KLVEGPPPPPEPPKT	MRPL22	171	Q9NWU5
GQLPSPPLLPTPPPK	PHACTR3	226	Q96KR7
SLPAPKGPALLPPPP	PRCC	41	Q92733
GPPPPKPSRPPIVNL	FYB2	276	Q5VWT5
PGKIPHQGPPLPPTP	PRR16	241	Q569H4
PPPTTPPVPKVEPKG	PRRC2A	606	P48634
PPGLPLPIPGALGPP	TAOK2	751	Q9UL54
PSLPAGPPGVKRPPP	SF3A2	221	Q15428
KLLPWEEGPGPPPPP	SHANK1	1836	Q9Y566
SPPVKAVPIQPPGPP	ATF6B	546	Q99941
PGPPPPSPLVGLKPL	ACVR2B	176	Q13705
PRGTPPPVFTPPLPK	ZCCHC8	476	Q6NZY4
PPVFTPPLPKGTPPL	ZCCHC8	481	Q6NZY4
ITPLPKPPPGVGLLP	ZC3H6	386	P61129
KAPPNLPPGVPPLLP	UBAP2L	786	Q14157
GPPDKIPPPTRPLPT	MMP16	291	P51512
PPTLPPPIPPKGEGE	ZBTB4	986	Q9P1Z0
PLPKPPPGVGLLPTP	ZC3H4	506	Q9UPT8
PPGVGLLPTPPRPPG	ZC3H4	511	Q9UPT8
LLKGTPPPPPPGLVP	ZNF598	691	Q86UK7
LPPKVTGPPPGTPQP	STRN4	366	Q9NRL3
GLVLPPPKGRLPAPP	TCIRG1	76	Q13488
TPLPRPPPGLTNPKP	TNRC6B	1596	Q9UPQ9
VGLRKPPPPPLLSPP	UNQ6190/PRO20217	46	Q6UXQ8
PGTPKPQGPTLEPPP	KMT2D	4341	O14686
LLPPPPGGKVTIPPP	NECAP1	186	Q8NC96