Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	DNHD1 ABCA2 ATP8B4 MYO1C MYO5A CENPE ABCA13 DDX54 HELZ DYNC1H1 DDX10	8.83e-05	614	89	11	GO:0140657
GeneOntologyMolecularFunction	histone H4K20me methyltransferase activity	PRDM9 SETD4	1.17e-04	4	89	2	GO:0140941
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	1.17e-04	4	89	2	GO:0005219
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 MYO1C MYO5A CENPE DYNC1H1	1.85e-04	118	89	5	GO:0003774
GeneOntologyMolecularFunction	histone H3K9 trimethyltransferase activity	PRDM9 SUV39H2	1.95e-04	5	89	2	GO:0140949
GeneOntologyMolecularFunction	actin binding	KLHL5 VPS18 DST MYO1C MYO5A CLMN SPTA1 STK38L ABLIM3	2.84e-04	479	89	9	GO:0003779
GeneOntologyMolecularFunction	histone H4K20 monomethyltransferase activity	PRDM9 SETD4	2.91e-04	6	89	2	GO:0140944
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	2.91e-04	6	89	2	GO:0048763
GeneOntologyMolecularFunction	p53 binding	MSX1 NOP53 TEP1 TP53BP2	3.89e-04	77	89	4	GO:0002039
GeneOntologyMolecularFunction	histone H4K20 methyltransferase activity	PRDM9 SETD4	8.64e-04	10	89	2	GO:0042799
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	PRDM9 SETD4 SUV39H2	9.93e-04	44	89	3	GO:0140938
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1F CACNA1S RYR1	1.13e-03	46	89	3	GO:0005245
GeneOntologyMolecularFunction	histone binding	VRK1 GK KDM4C PHF14 H1-9P DNAJC2	1.20e-03	265	89	6	GO:0042393
GeneOntologyMolecularFunction	histone H3K9 methyltransferase activity	PRDM9 SUV39H2	1.48e-03	13	89	2	GO:0046974
GeneOntologyMolecularFunction	histone H3K36 methyltransferase activity	PRDM9 SETD4	1.48e-03	13	89	2	GO:0046975
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1F CACNA1S	1.73e-03	14	89	2	GO:0008331
GeneOntologyMolecularFunction	transcription factor binding	TCP10L MSX2 CCNT2 SP100 NFIA KDM4C PCLO DDX54 TP53BP2 STAT6	1.90e-03	753	89	10	GO:0008134
GeneOntologyMolecularFunction	histone H4 methyltransferase activity	PRDM9 SETD4	2.56e-03	17	89	2	GO:0140939
GeneOntologyMolecularFunction	calcium channel activity	CACNA1F CACNA1S RYR1 RYR2	2.66e-03	129	89	4	GO:0005262
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNHD1 DYNC1H1	2.87e-03	18	89	2	GO:0008569
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR2	2.87e-03	18	89	2	GO:0015278
GeneOntologyMolecularFunction	actin filament binding	MYO1C MYO5A CLMN SPTA1 ABLIM3	3.48e-03	227	89	5	GO:0051015
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	PRDM9 SETD4 SUV39H2	3.48e-03	68	89	3	GO:0016279
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	PRDM9 SETD4	3.54e-03	20	89	2	GO:0042800
GeneOntologyMolecularFunction	histone modifying activity	VRK1 PRDM9 KDM4C SETD4 SUV39H2	3.61e-03	229	89	5	GO:0140993
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	PRDM9 SETD4 SUV39H2	3.63e-03	69	89	3	GO:0016278
GeneOntologyMolecularFunction	calmodulin binding	CACNA1S MYO1C MYO5A RYR1 RYR2	3.68e-03	230	89	5	GO:0005516
GeneOntologyMolecularFunction	microtubule motor activity	DNHD1 CENPE DYNC1H1	3.78e-03	70	89	3	GO:0003777
GeneOntologyMolecularFunction	manganese ion binding	ADCY10 B4GALT7 PPM1N	3.93e-03	71	89	3	GO:0030145
GeneOntologyMolecularFunction	histone methyltransferase activity	PRDM9 SETD4 SUV39H2	3.93e-03	71	89	3	GO:0042054
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1F CACNA1S RYR1 RYR2	4.67e-03	151	89	4	GO:0015085
GeneOntologyBiologicalProcess	cellular response to caffeine	CACNA1S RYR1 RYR2	1.13e-05	11	86	3	GO:0071313
GeneOntologyBiologicalProcess	cellular response to purine-containing compound	CACNA1S RYR1 RYR2	2.46e-05	14	86	3	GO:0071415
GeneOntologyBiologicalProcess	biological phase	MSX2 MYO5A NFIA NFIX	7.06e-05	53	86	4	GO:0044848
GeneOntologyBiologicalProcess	response to caffeine	CACNA1S RYR1 RYR2	8.82e-05	21	86	3	GO:0031000
GeneOntologyBiologicalProcess	positive regulation of mesenchymal cell apoptotic process	MSX1 MSX2	1.03e-04	4	86	2	GO:2001055
GeneOntologyBiologicalProcess	embryonic nail plate morphogenesis	MSX1 MSX2	1.03e-04	4	86	2	GO:0035880
MousePheno	abnormal sarcoplasmic reticulum morphology	CACNA1S STUB1 RYR1 RYR2	5.94e-06	23	74	4	MP:0004088
MousePheno	abnormal muscle fiber mitochondrial morphology	CACNA1S DST RYR1 RYR2	2.64e-05	33	74	4	MP:0014342
MousePheno	abnormal skeletal muscle fiber mitochondrial morphology	CACNA1S DST RYR1	3.03e-05	12	74	3	MP:0014344
Domain	Ryanodine_rcpt	RYR1 RYR2	6.72e-05	3	89	2	IPR003032
Domain	Ryanrecept_TM4-6	RYR1 RYR2	6.72e-05	3	89	2	IPR009460
Domain	RyR	RYR1 RYR2	6.72e-05	3	89	2	PF02026
Domain	RR_TM4-6	RYR1 RYR2	6.72e-05	3	89	2	PF06459
Domain	Ryan_recept	RYR1 RYR2	6.72e-05	3	89	2	IPR013333
Domain	CTF_NFI	NFIA NFIX	1.34e-04	4	89	2	PF00859
Domain	CTF_NFI_1	NFIA NFIX	1.34e-04	4	89	2	PS00349
Domain	CTF_NFI_2	NFIA NFIX	1.34e-04	4	89	2	PS51080
Domain	CTF/NFI_DNA-bd-dom	NFIA NFIX	1.34e-04	4	89	2	IPR020604
Domain	VDCC_L_a1su	CACNA1F CACNA1S	1.34e-04	4	89	2	IPR005446
Domain	NfI_DNAbd_pre-N	NFIA NFIX	1.34e-04	4	89	2	PF10524
Domain	CTF/NFI	NFIA NFIX	1.34e-04	4	89	2	IPR000647
Domain	CTF/NFI_DNA-bd_N	NFIA NFIX	1.34e-04	4	89	2	IPR019548
Domain	CTF/NFI_DNA-bd_CS	NFIA NFIX	1.34e-04	4	89	2	IPR019739
Domain	RIH_assoc-dom	RYR1 RYR2	3.33e-04	6	89	2	IPR013662
Domain	Ins145_P3_rec	RYR1 RYR2	3.33e-04	6	89	2	PF08709
Domain	RIH_assoc	RYR1 RYR2	3.33e-04	6	89	2	PF08454
Domain	RIH_dom	RYR1 RYR2	3.33e-04	6	89	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	3.33e-04	6	89	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	3.33e-04	6	89	2	IPR015925
Domain	-	RYR1 RYR2	3.33e-04	6	89	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2	3.33e-04	6	89	2	PF01365
Domain	EF-hand-dom_pair	CACNA1F CACNA1S DST SPTA1 RYR1 RYR2 STAT6	4.42e-04	287	89	7	IPR011992
Domain	Ca_chan_IQ	CACNA1F CACNA1S	4.64e-04	7	89	2	SM01062
Domain	Ca_chan_IQ	CACNA1F CACNA1S	4.64e-04	7	89	2	PF08763
Domain	VDCC_a1su_IQ	CACNA1F CACNA1S	4.64e-04	7	89	2	IPR014873
Domain	GPHH	CACNA1F CACNA1S	4.64e-04	7	89	2	PF16905
Domain	GPHH_dom	CACNA1F CACNA1S	4.64e-04	7	89	2	IPR031649
Domain	P-loop_NTPase	ADCY10 DNHD1 ABCA2 MYO1C MYO5A CENPE ABCA13 DDX54 HELZ TEP1 DYNC1H1 DDX10	6.76e-04	848	89	12	IPR027417
Domain	SET	PRDM9 SETD4 SUV39H2	9.78e-04	41	89	3	PF00856
Domain	MIR	RYR1 RYR2	9.86e-04	10	89	2	PF02815
Domain	MIR_motif	RYR1 RYR2	9.86e-04	10	89	2	IPR016093
Domain	MIR	RYR1 RYR2	9.86e-04	10	89	2	PS50919
Domain	MIR	RYR1 RYR2	9.86e-04	10	89	2	SM00472
Domain	VDCCAlpha1	CACNA1F CACNA1S	9.86e-04	10	89	2	IPR002077
Domain	MAD_homology1_Dwarfin-type	NFIA NFIX	1.44e-03	12	89	2	IPR003619
Domain	DWA	NFIA NFIX	1.44e-03	12	89	2	SM00523
Domain	ABC_A	ABCA2 ABCA13	1.44e-03	12	89	2	IPR026082
Domain	MH1	NFIA NFIX	1.44e-03	12	89	2	PF03165
Domain	SET_dom	PRDM9 SETD4 SUV39H2	1.74e-03	50	89	3	IPR001214
Domain	SET	PRDM9 SETD4 SUV39H2	1.74e-03	50	89	3	PS50280
Domain	Dynein_HC_stalk	DNHD1 DYNC1H1	1.97e-03	14	89	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DYNC1H1	1.97e-03	14	89	2	IPR013602
Domain	DHC_N2	DNHD1 DYNC1H1	1.97e-03	14	89	2	PF08393
Domain	MT	DNHD1 DYNC1H1	1.97e-03	14	89	2	PF12777
Domain	Ion_trans_dom	CACNA1F CACNA1S RYR1 RYR2	2.16e-03	114	89	4	IPR005821
Domain	Ion_trans	CACNA1F CACNA1S RYR1 RYR2	2.16e-03	114	89	4	PF00520
Domain	DHC_fam	DNHD1 DYNC1H1	2.26e-03	15	89	2	IPR026983
Domain	Dynein_heavy	DNHD1 DYNC1H1	2.26e-03	15	89	2	PF03028
Domain	Spectrin_alpha_SH3	SPTA1 TP53BP2	2.26e-03	15	89	2	IPR013315
Domain	Dynein_heavy_dom	DNHD1 DYNC1H1	2.26e-03	15	89	2	IPR004273
Domain	IQ	MYO1C MYO5A UBE3C	4.73e-03	71	89	3	PF00612
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1S RYR1 RYR2	1.96e-05	11	71	3	M47958
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DST WDR36 MYO1C SUGP2 MYO5A NOP53 POLE DDX54 HELZ TEX10 PRPF40A DYNC1H1 DDX10	1.40e-08	653	90	13	22586326
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	NFIX RYR1 RYR2	6.69e-08	4	90	3	23482488
Pubmed	Human transcription factor protein interaction networks.	DST ACACB STUB1 MYO1C SUGP2 MYO5A NFIA NOP53 NFIX DDX54 HELZ TEX10 PRPF40A CNOT3 DYNC1H1 DDX10 SENP5	1.34e-07	1429	90	17	35140242
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 KLHL5 DST ACACB MYO5A CENPE DDX54 PRPF40A	1.80e-07	234	90	8	36243803
Pubmed	Postsynaptic CaV1.1-driven calcium signaling coordinates presynaptic differentiation at the developing neuromuscular junction.	CACNA1S PCLO RYR1	3.33e-07	6	90	3	31804576
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CACNA1F DST CENPE VPS13C PCLO PHF14 OR4B1 SAMD3 CPT1B DYNC1H1 RYR1 DIPK2B	4.48e-07	736	90	12	29676528
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	CCNT2 VRK1 WDR36 NFIA NOP53 AURKAIP1 TEX10 PRPF40A DYNC1H1 DDX10	1.26e-06	533	90	10	30554943
Pubmed	Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation.	MSX1 MSX2 STAT6	1.98e-06	10	90	3	21945076
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	CACNA1S RYR1 RYR2	1.98e-06	10	90	3	18434328
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	WDR36 SUGP2 NOP53 DDX54 HELZ PHF14 TEX10 DDX10	3.60e-06	349	90	8	25665578
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CCNT2 RAPGEF6 FAM13A STUB1 MYO1C SUGP2 NFIA HELZ PHF14 PRPF40A CNOT3	5.21e-06	774	90	11	15302935
Pubmed	Insertional mutation of the mouse Msx1 homeobox gene by an nlacZ reporter gene.	MSX1 MSX2	6.62e-06	2	90	2	9256350
Pubmed	Disruption of Msx-1 and Msx-2 reveals roles for these genes in craniofacial, eye, and axial development.	MSX1 MSX2	6.62e-06	2	90	2	9142497
Pubmed	Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle.	CACNA1S RYR1	6.62e-06	2	90	2	12954602
Pubmed	Msx1 and Msx2 gene expression is downregulated in the cadmium-induced omphalocele in the chick model.	MSX1 MSX2	6.62e-06	2	90	2	20620318
Pubmed	Fluorescence resonance energy transfer (FRET) indicates that association with the type I ryanodine receptor (RyR1) causes reorientation of multiple cytoplasmic domains of the dihydropyridine receptor (DHPR) α(1S) subunit.	CACNA1S RYR1	6.62e-06	2	90	2	23071115
Pubmed	Investigating the genetic susceptibility to exertional heat illness.	CACNA1S RYR1	6.62e-06	2	90	2	32054689
Pubmed	MSX-1 gene expression and regulation in embryonic palatal tissue.	MSX1 MSX2	6.62e-06	2	90	2	9870533
Pubmed	Ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice.	MSX1 MSX2	6.62e-06	2	90	2	15803476
Pubmed	Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape.	MSX1 MSX2	6.62e-06	2	90	2	1358591
Pubmed	Effects of conformational peptide probe DP4 on bidirectional signaling between DHPR and RyR1 calcium channels in voltage-clamped skeletal muscle fibers.	CACNA1S RYR1	6.62e-06	2	90	2	21575570
Pubmed	Ectoderm-mesenchyme and mesenchyme-mesenchyme interactions regulate Msx-1 expression and cellular differentiation in the murine limb bud.	MSX1 MSX2	6.62e-06	2	90	2	7537232
Pubmed	Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle.	CACNA1S RYR1	6.62e-06	2	90	2	12496092
Pubmed	Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian.	MSX1 MSX2	6.62e-06	2	90	2	1673109
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	6.62e-06	2	90	2	17259277
Pubmed	Differential impact of MSX1 and MSX2 homeogenes on mouse maxillofacial skeleton.	MSX1 MSX2	6.62e-06	2	90	2	18769023
Pubmed	Clinical utility gene card for: malignant hyperthermia.	CACNA1S RYR1	6.62e-06	2	90	2	21248738
Pubmed	Exome sequencing reveals novel rare variants in the ryanodine receptor and calcium channel genes in malignant hyperthermia families.	CACNA1S RYR1	6.62e-06	2	90	2	24013571
Pubmed	Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy.	MSX1 MSX2	6.62e-06	2	90	2	8861098
Pubmed	Regulated expression of homeobox genes Msx-1 and Msx-2 in mouse mammary gland development suggests a role in hormone action and epithelial-stromal interactions.	MSX1 MSX2	6.62e-06	2	90	2	8660900
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	6.62e-06	2	90	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	6.62e-06	2	90	2	26009179
Pubmed	Comparison of pathogenicity prediction tools on missense variants in RYR1 and CACNA1S associated with malignant hyperthermia.	CACNA1S RYR1	6.62e-06	2	90	2	27147545
Pubmed	Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C.	KDM4C SUV39H2	6.62e-06	2	90	2	28396876
Pubmed	Analysis of the entire ryanodine receptor type 1 and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) coding regions for variants associated with malignant hyperthermia in Australian families.	CACNA1S RYR1	6.62e-06	2	90	2	25735680
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	6.62e-06	2	90	2	32899693
Pubmed	Functional expression of transgenic 1sDHPR channels in adult mammalian skeletal muscle fibres.	CACNA1S RYR1	6.62e-06	2	90	2	21262876
Pubmed	Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth.	MSX1 MSX2	6.62e-06	2	90	2	8101167
Pubmed	The alpha(1S) III-IV loop influences 1,4-dihydropyridine receptor gating but is not directly involved in excitation-contraction coupling interactions with the type 1 ryanodine receptor.	CACNA1S RYR1	6.62e-06	2	90	2	18556650
Pubmed	Conditional alleles of Msx1 and Msx2.	MSX1 MSX2	6.62e-06	2	90	2	17654563
Pubmed	Distinct Components of Retrograde Ca(V)1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1.	CACNA1S RYR1	6.62e-06	2	90	2	26910427
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	6.62e-06	2	90	2	30542613
Pubmed	Msx homeobox gene family and craniofacial development.	MSX1 MSX2	6.62e-06	2	90	2	14728799
Pubmed	Increasing the number of diagnostic mutations in malignant hyperthermia.	CACNA1S RYR1	6.62e-06	2	90	2	19191329
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	6.62e-06	2	90	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	6.62e-06	2	90	2	11673493
Pubmed	Morphology and molecular composition of sarcoplasmic reticulum surface junctions in the absence of DHPR and RyR in mouse skeletal muscle.	CACNA1S RYR1	6.62e-06	2	90	2	12023238
Pubmed	Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle.	CACNA1S RYR1	6.62e-06	2	90	2	9199552
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	6.62e-06	2	90	2	11673462
Pubmed	Msh homeobox 1 (Msx1)- and Msx2-overexpressing bone marrow-derived mesenchymal stem cells resemble blastema cells and enhance regeneration in mice.	MSX1 MSX2	6.62e-06	2	90	2	28461333
Pubmed	[Induction phenomena during vertebrate limb development and homeo box gene expression].	MSX1 MSX2	6.62e-06	2	90	2	8099267
Pubmed	Next-generation Sequencing of RYR1 and CACNA1S in Malignant Hyperthermia and Exertional Heat Illness.	CACNA1S RYR1	6.62e-06	2	90	2	25658027
Pubmed	The Msh-like homeobox genes define domains in the developing vertebrate eye.	MSX1 MSX2	6.62e-06	2	90	2	1682128
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	6.62e-06	2	90	2	25370123
Pubmed	Quantitative reduction of RyR1 protein caused by a single-allele frameshift mutation in RYR1 ex36 impairs the strength of adult skeletal muscle fibres.	CACNA1S RYR1	6.62e-06	2	90	2	30689883
Pubmed	Four calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation.	CACNA1S RYR1	6.62e-06	2	90	2	35509066
Pubmed	Generation of an Msx2-GFP conditional null allele.	MSX1 MSX2	6.62e-06	2	90	2	18442049
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	6.62e-06	2	90	2	15033925
Pubmed	Rescue of the limb deformity in hammertoe mutant mice by retinoic acid-induced cell death.	MSX1 MSX2	6.62e-06	2	90	2	9097019
Pubmed	The function and evolution of Msx genes: pointers and paradoxes.	MSX1 MSX2	6.62e-06	2	90	2	7482767
Pubmed	Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice.	MSX1 MSX2	6.62e-06	2	90	2	31221479
Pubmed	Position-dependent expression of two related homeobox genes in developing vertebrate limbs.	MSX1 MSX2	6.62e-06	2	90	2	1677742
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	6.62e-06	2	90	2	18618700
Pubmed	RYR1 and CACNA1S genetic variants identified with statin-associated muscle symptoms.	CACNA1S RYR1	6.62e-06	2	90	2	30325262
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DNHD1 VRK1 ATP8B4 WDR36 MYO1C NOP53 VPS13C POLE PCLO DDX54 UBE3C PRPF40A DYNC1H1 DDX10	1.73e-05	1425	90	14	30948266
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	ADCY10 DNHD1 MYO1C ABCA13 EXPH5 RYR1	1.75e-05	208	90	6	33230847
Pubmed	Bayesian modeling to predict malignant hyperthermia susceptibility and pathogenicity of RYR1, CACNA1S and STAC3 variants.	CACNA1S RYR1	1.98e-05	3	90	2	31559918
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	1.98e-05	3	90	2	18403125
Pubmed	Characteristic tissue interaction of the diastema region in mice.	MSX1 MSX2	1.98e-05	3	90	2	15812993
Pubmed	Analysis of Msx1 and Msx2 transactivation function in the context of the heat shock 70 (Hspa1b) gene promoter.	MSX1 MSX2	1.98e-05	3	90	2	19338779
Pubmed	Regulation of proliferation in developing human tooth germs by MSX homeodomain proteins and cyclin-dependent kinase inhibitor p19INK4d.	MSX1 MSX2	1.98e-05	3	90	2	28933666
Pubmed	Two Types of Etiological Mutation in the Limb-Specific Enhancer of Shh.	MSX1 MSX2	1.98e-05	3	90	2	28710291
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	1.98e-05	3	90	2	18434746
Pubmed	Msx1CreERT2 knock-In allele: A useful tool to target embryonic and adult cardiac valves.	MSX1 MSX2	1.98e-05	3	90	2	25950518
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	1.98e-05	3	90	2	9204703
Pubmed	A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma.	MSX1 MSX2	1.98e-05	3	90	2	32210188
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	1.98e-05	3	90	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	1.98e-05	3	90	2	21881589
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	1.98e-05	3	90	2	24123915
Pubmed	The murine homeobox gene Msx-3 shows highly restricted expression in the developing neural tube.	MSX1 MSX2	1.98e-05	3	90	2	8861099
Pubmed	Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling.	CACNA1S RYR1	1.98e-05	3	90	2	16357209
Pubmed	Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures.	CACNA1S RYR1	1.98e-05	3	90	2	11206130
Pubmed	Malignant Hyperthermia Susceptibility	CACNA1S RYR1	1.98e-05	3	90	2	20301325
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	1.98e-05	3	90	2	12213830
Pubmed	Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification.	NFIA NFIX	1.98e-05	3	90	2	31128945
Pubmed	Msx Homeobox Genes Act Downstream of BMP2 to Regulate Endometrial Decidualization in Mice and in Humans.	MSX1 MSX2	1.98e-05	3	90	2	31125045
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	1.98e-05	3	90	2	23278119
Pubmed	LIM homeobox transcription factor Lhx2 inhibits skeletal muscle differentiation in part via transcriptional activation of Msx1 and Msx2.	MSX1 MSX2	1.98e-05	3	90	2	25460335
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2	1.98e-05	3	90	2	9242641
Pubmed	Targeted reduction of vascular Msx1 and Msx2 mitigates arteriosclerotic calcification and aortic stiffness in LDLR-deficient mice fed diabetogenic diets.	MSX1 MSX2	1.98e-05	3	90	2	25056439
Pubmed	Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice.	MSX1 MSX2	1.98e-05	3	90	2	7538067
Pubmed	Malleal processus brevis is dispensable for normal hearing in mice.	MSX1 MSX2	1.98e-05	3	90	2	12701100
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	1.98e-05	3	90	2	22948152
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	1.98e-05	3	90	2	23454728
Pubmed	STAC3 incorporation into skeletal muscle triads occurs independent of the dihydropyridine receptor.	CACNA1S RYR1	1.98e-05	3	90	2	30071129
Pubmed	STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function.	CACNA1S RYR1	1.98e-05	3	90	2	30543836
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	1.98e-05	3	90	2	10788707
Pubmed	Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2+ channels.	CACNA1S RYR1	1.98e-05	3	90	2	25548159
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2	1.98e-05	3	90	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	1.98e-05	3	90	2	7621815
Interaction	PSKH2 interactions	STUB1 SUGP2 MYO5A NOP53 DYNC1H1	1.17e-05	67	89	5	int:PSKH2
Interaction	RPS24 interactions	MSX2 VRK1 WDR36 NFIA NOP53 DDX54 RRM1 TEX10 DYNC1H1 DNAJC2 DDX10	2.11e-05	529	89	11	int:RPS24
Interaction	SIRT7 interactions	DST WDR36 MYO1C SUGP2 MYO5A NOP53 POLE DDX54 HELZ TEX10 PRPF40A DYNC1H1 DDX10	2.25e-05	744	89	13	int:SIRT7
Interaction	PRPH interactions	TCP10L STUB1 MYO5A EXPH5 VPS13C STK38L TP53BP2	3.36e-05	204	89	7	int:PRPH
Interaction	ATXN1 interactions	MSX2 SP100 ACACB STUB1 MYO1C SUGP2 MYO5A NFIA NFIX SORCS3 TRIM38 PRPF40A CNOT3 DYNC1H1 DNAJC2	4.62e-05	1039	89	15	int:ATXN1
Interaction	SAMD3 interactions	ACACB SUGP2 SAMD3	5.41e-05	17	89	3	int:SAMD3
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	3.46e-05	3	62	2	287
GeneFamily	ATP binding cassette subfamily A	ABCA2 ABCA13	1.03e-03	14	62	2	805
Coexpression	GSE42021_CD24HI_VS_CD24LOW_TREG_THYMUS_DN	KIAA0408 MSX1 SP100 RAPGEF6 PCLO DAPP1 TRIM38	5.93e-06	200	90	7	M9588
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VRK1 PRDM9 ATP8B4 DAPP1 PLEK TEP1 RYR1	4.93e-08	167	90	7	fd84a99ea142d1684cdcf4a88ef1d541760bc78a
ToppCell	severe-Myeloid-Immature_Neutrophils_2\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	VRK1 ATP8B4 CENPE ABCA13 POLE PCLO RRM1	1.58e-07	198	90	7	844f534551483c89ef789d1cfeb4680e54f794b2
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ATP8B4 MYO5A SPTA1 PLEK PPM1N TIAM2	1.67e-06	178	90	6	aa9f68a66e292f331faef881bbd0d028f0f2b0c5
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBXL13 SUGP2 SPTA1 MARCHF2 DAPP1 PLEK	1.78e-06	180	90	6	ca2a35bfb67347e47f511589a3d0f763e6664634
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBXL13 SUGP2 SPTA1 MARCHF2 DAPP1 PLEK	1.78e-06	180	90	6	4e9e8cde2919610c4ac0025b1c9819808048bc1d
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBXL13 SUGP2 SPTA1 MARCHF2 DAPP1 PLEK	1.78e-06	180	90	6	466381bf93c3da6a2a241daadb68e9aad2964eae
ToppCell	normal_Lung-Myeloid_cells-CD207+CD1a+_LCs\|normal_Lung / Location, Cell class and cell subclass	CD1E ATP8B4 CENPE DAPP1 PPM1N TIAM2	1.84e-06	181	90	6	b55dbcfae8c92d322071906831489830a22239b9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 CACNA1F ABCA13 SPTA1 PCLO RYR2	2.02e-06	184	90	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 CACNA1F ABCA13 SPTA1 PCLO RYR2	2.02e-06	184	90	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 CACNA1F ABCA13 SPTA1 PCLO RYR2	2.02e-06	184	90	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXO48 DST ACACB ABCA13 PCSK6 RYR2	2.15e-06	186	90	6	8eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD1E ATP8B4 GK DAPP1 PLEK STK38L	2.74e-06	194	90	6	bde6830a281f7cd7fd1733e40a41ddd2673ba88e
ToppCell	severe-Myeloid-Immature_Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	VRK1 ATP8B4 CENPE ABCA13 POLE RRM1	3.08e-06	198	90	6	e36303628af3139310c1d7a84d2919b7319bbda4
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FBXO48 CD1E ATP8B4 GK DAPP1 PLEK	3.17e-06	199	90	6	d330e28075096a09da3c27db8b52e364967c1e34
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	SP100 KLHL5 DST VPS13C PCLO TRIM38	3.17e-06	199	90	6	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRDM9 ATP8B4 PLEK TEP1 RYR1	2.13e-05	165	90	5	2477b0f1a0ea26184cf3cc4a9ffcdfa825cbc615
ToppCell	droplet-Marrow-nan-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP100 KIAA0825 POLE SPTA1 TEP1	2.39e-05	169	90	5	5f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SPTA1 PCLO SORCS3 RYR2	2.39e-05	169	90	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VRK1 DAPP1 PLEK TEP1 RYR1	2.46e-05	170	90	5	6686d1797988216c0d9417f21a2537369abce410
ToppCell	facs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VRK1 ATP8B4 DAPP1 PLEK RYR1	2.60e-05	172	90	5	eaba10a4d4eaab42ad2e2da65ebb20b50edaf815
ToppCell	PCW_13-14-Hematologic_ErythroMegGranulo-Hem_ErythroMeg\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SPTA1 FAM157C MARCHF2 DAPP1 PLEK	2.83e-05	175	90	5	c33317d8d60ea88ec326daf91dfd3416a62f9938
ToppCell	CF-Myeloid-Neutrophil\|Myeloid / Disease state, Lineage and Cell class	VPS18 GK FBXL13 KIAA0825 PLEK	2.83e-05	175	90	5	8020c3a34f77e68e8149f87481fb1dddd2ac675e
ToppCell	facs-Lung-EPCAM-18m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 ATP8B4 DAPP1 PLEK RYR1	2.99e-05	177	90	5	7bc92314b22a876296a4e2db51e7fb0fdfd69379
ToppCell	facs-Lung-EPCAM-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 ATP8B4 DAPP1 PLEK RYR1	2.99e-05	177	90	5	e73e2b6a72630bb56ac2af1cdeedc8f0f828f390
ToppCell	Severe-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CACNA1S PCSK6 DAPP1 PLEK RYR1	3.07e-05	178	90	5	b7374a97c51239782bed658381a02cb1b3d9bf66
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VRK1 ATP8B4 DAPP1 PLEK RYR1	3.15e-05	179	90	5	55fde77dae7f9e7f3431c3185d14212a25af83df
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CENPE POLE E2F2 SAMD3 RRM1	3.32e-05	181	90	5	e4dbc09f0210de465d8347969b301c22463a2b7d
ToppCell	normal_Lung-Myeloid_cells-CD207+CD1a+_LCs\|Myeloid_cells / Location, Cell class and cell subclass	CD1E ATP8B4 CENPE PPM1N TIAM2	3.41e-05	182	90	5	8dd79fef8f8463ad3194f9cc07c6cacf2c886304
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_NK-NK_CD56bright_CD16-\|lymph-node_spleen / Manually curated celltypes from each tissue	ABCA2 ATP8B4 SUGP2 HELZ SAMD3	3.88e-05	187	90	5	9000241566f48e435db9409b7255db68b68f6059
ToppCell	(0)_NK_CD160pos\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	ABCA2 ATP8B4 HELZ SAMD3 PLEK	4.08e-05	189	90	5	713991025bb92d38cb0507ff01fd91b48c8af45a
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXO48 CENPE CGAS RRM1 ABLIM3	4.19e-05	190	90	5	b99271d139c8d01e20feb95d99f79c9b2756b4cb
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	SP100 DST PTPRM NFIX ABLIM3	4.19e-05	190	90	5	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	proximal-Hematologic-Platelet/Megakaryocyte\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	VPS18 KIAA0825 CGAS E2F2 CPT1B	4.40e-05	192	90	5	522d1bb15edf1d6006b80289bd3baadb99584ae8
ToppCell	proximal-3-Hematologic-Platelet/Megakaryocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	VPS18 KIAA0825 CGAS E2F2 CPT1B	4.40e-05	192	90	5	f5f83dec37dff32a0c471cb05d23d13b0b0ad0c9
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST ACACB ABCA13 PCLO PCSK6	4.40e-05	192	90	5	e19e3e8edcc08e4a67873bfb6e46489ca6c8756a
ToppCell	proximal-Hematologic-Platelet/Megakaryocyte-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	VPS18 KIAA0825 CGAS E2F2 CPT1B	4.40e-05	192	90	5	57899a905ca3e336bb7f31edc6418a2546b9891a
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST ACACB ABCA13 PCLO PCSK6	4.40e-05	192	90	5	61c2caf6c838132ed5faa8791c288f2149eba2c8
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NFIA ABCA13 CLMN EXPH5 NFIX	4.51e-05	193	90	5	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	COVID-19-T_cells-Cycling_NK/T_cells\|COVID-19 / group, cell type (main and fine annotations)	VRK1 CENPE SPTA1 E2F2 RRM1	4.74e-05	195	90	5	764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B4 GK MYO5A PLEK RYR1	4.97e-05	197	90	5	8af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell	severe-unassigned\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ATP8B4 FBXL13 CENPE ABCA13 E2F2	4.97e-05	197	90	5	70704b149b2820b8601d2495b7cd9cbe91eda262
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD1E ATP8B4 GK PLEK STK38L	4.97e-05	197	90	5	a902aa05e5f711bcfdd9e19749ab636b597eb116
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD1E ATP8B4 DST STK38L RYR1	5.09e-05	198	90	5	d0371e2ca9e25727b35985940f6228f9d8e49727
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CACNA1F BMP3 GK FAM13A TP53BP2	5.09e-05	198	90	5	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD1E ATP8B4 DST STK38L RYR1	5.09e-05	198	90	5	08ad0bece508bb4f9cc126d94839b5c89ce21ba8
ToppCell	Severe-B_intermediate-10\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	VPS13C PCSK6 DAPP1 PLEK RYR1	5.09e-05	198	90	5	dfae26c3513a82bb7cb8dadbfcea2a1f420b1bab
ToppCell	control-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CD1E DST DAPP1 STK38L RYR1	5.22e-05	199	90	5	31825ba336603fe940dea6022e18ec25af110f4c
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	DNHD1 MSX2 RAPGEF6 ZNF268 CPT1B	5.22e-05	199	90	5	fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells-Neuroepithelial_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	VRK1 CENPE NFIA E2F2 RRM1	5.34e-05	200	90	5	8f8b8c225cdc79baf16fe04be89bdb65e404a055
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells\|10w / Sample Type, Dataset, Time_group, and Cell type.	VRK1 CENPE NFIA E2F2 RRM1	5.34e-05	200	90	5	a1f48eca9efb4f3ec3c9ace20f8c9257dd72c4ed
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DST ABCA13 EXPH5 NFIX PCLO	5.34e-05	200	90	5	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CD1E ATP8B4 DAPP1 PLEK STK38L	5.34e-05	200	90	5	f0e7c2f07a7065511bf0b6521ce2e74e04e48544
ToppCell	Biopsy_Control_(H.)-Immune-cDCs\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CD1E ATP8B4 DAPP1 PLEK STK38L	5.34e-05	200	90	5	cc6ba99a877a13c63dc1d6f81538065a7f29b8f6
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	VRK1 CENPE E2F2 RRM1 SUV39H2	5.34e-05	200	90	5	cfec2f712b870797fab3b0770f16feaafd37e8d5
ToppCell	erythropoietic-Polychromatic_Erythroblast\|erythropoietic / Lineage and Cell class	VRK1 FAM13A NFIA SPTA1 RRM1	5.34e-05	200	90	5	27056f28328df2a51d5634a7927b7084241e3ca2
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	VRK1 CENPE POLE E2F2 RRM1	5.34e-05	200	90	5	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DST ABCA13 EXPH5 NFIX PCLO	5.34e-05	200	90	5	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	droplet-Heart-nan-3m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ATP8B4 SPTA1 RYR1	1.86e-04	140	90	4	ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Erythrocyte\|Erythro-cells / Lineage, cell class and subclass	NFIX SPTA1 MARCHF2 E2F2	2.08e-04	144	90	4	7fbedc65314cfb06bcc527d794b5de7858f7c5ec
ToppCell	remission-multiplets\|remission / disease stage, cell group and cell class	CACNA1F ATP8B4 ABCA13 TP53BP2	2.37e-04	149	90	4	e9974260a5f2999b363f306cae005698c912893a
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VRK1 DAPP1 TEP1 RYR1	2.37e-04	149	90	4	32e0be7da42d26956683b21a1e7ae6915e4c16fb
ToppCell	droplet-Fat-Scat-21m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 PLEK TEP1 RYR1	2.49e-04	151	90	4	79827a76c675dcb82f59c0a45d0f962b02d5bfd6
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SP100 ATP8B4 CGAS SAMD3	2.62e-04	153	90	4	e25ddf75d78edfac962c8ec503c9f70f0f7f25bc
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRDM9 ATP8B4 CENPE CGAS	2.68e-04	154	90	4	e3a8a1e63ab345de62bd2e5e54342b00f04ae422
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VRK1 MYO5A TEP1 DNAJC2	2.68e-04	154	90	4	c663e9834be0b45389a862dc3c13a1f988a3e5ee
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADCY10 SAMD3 RYR1 TIAM2	2.82e-04	156	90	4	2cd007b423c2395c5ce331902e7f27c805755eb3
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VRK1 ATP8B4 CENPE VPS13C	2.89e-04	157	90	4	904cd98ae85ed6459e0663f077ac462842bf12df
ToppCell	E15.5-Hematopoietic\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ATP8B4 SPTA1 MARCHF2 PLEK	2.89e-04	157	90	4	6315aef4b9bf673069d43a730d4e940011509ac1
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	MSX2 CD1E STK38L TP53BP2	2.89e-04	157	90	4	7ceae5fe00c91d4feb8c314d3a31f027c03fa56f
ToppCell	COPD-Myeloid-DC_Langerhans\|COPD / Disease state, Lineage and Cell class	CD1E ATP8B4 DAPP1 PPM1N	2.96e-04	158	90	4	71af1319eec34bf7bc9361ec9ef720c280ce97d1
ToppCell	Posterior_cortex\|World / BrainAtlas - Mouse McCarroll V32	BMP3 EXPH5 NFIX RYR2	3.03e-04	159	90	4	18e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCell	droplet-Heart-nan-24m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 ABCA2 FBXL13 SETD4	3.03e-04	159	90	4	7ad3a91d29639b32f6264c91f401c14a35469ac0
ToppCell	COPD-Myeloid-DC_Langerhans\|World / Disease state, Lineage and Cell class	CD1E ATP8B4 DAPP1 PPM1N	3.10e-04	160	90	4	1b73a14ad6546d9f2812c19081278a79260abeae
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAPP1 PLEK TEP1 RYR1	3.10e-04	160	90	4	5c28121916a12dbc22ef2421040bdc9148a40b78
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAPP1 PLEK TEP1 RYR1	3.10e-04	160	90	4	b7093678987575f2f99d648821d31b4a37075aca
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S SP100 ATP8B4 PLEK	3.18e-04	161	90	4	16f77e7a5444d2f2b210362816cd7a07b9b42af6
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S SP100 ATP8B4 PLEK	3.18e-04	161	90	4	f5821f551cf5c64c9f75cdb723492c87aac1ece0
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S SP100 ATP8B4 PLEK	3.18e-04	161	90	4	58a32a1033f379579697bda1bbf047a088e4a34f
ToppCell	11.5-Distal-RBC\|Distal / Age, Tissue, Lineage and Cell class	SPTA1 MARCHF2 E2F2 SAMD3	3.33e-04	163	90	4	e9d814952d824539ff1dea119e4fca14a8c335a8
ToppCell	11.5-Distal-RBC-RBC\|Distal / Age, Tissue, Lineage and Cell class	SPTA1 MARCHF2 E2F2 SAMD3	3.33e-04	163	90	4	31b60e065bac4ad380247964e7574f210106ebae
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP3 VRK1 PTPRM NFIX	3.41e-04	164	90	4	08819970174a3eb4eee8e1e675075828665b845e
ToppCell	facs-MAT-Fat-3m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAPP1 PLEK TEP1 RYR1	3.41e-04	164	90	4	b81498c3934e0d52bf0329dc745e02966f9d8613
ToppCell	COPD-Myeloid-DC_Langerhans\|Myeloid / Disease state, Lineage and Cell class	CD1E ATP8B4 DAPP1 PPM1N	3.41e-04	164	90	4	a07c6e13c07a90bc37db0915eb14931eb8309a1e
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S SUGP2 SAMD3 IKBKB	3.49e-04	165	90	4	8c7a6f9e2ca0ce077426d3d0726e3f5a4c03b296
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1F CD1E DAPP1 PLEK	3.49e-04	165	90	4	d8b0a9b6f704b98e8f0412c11739879a26c036e2
ToppCell	PCW_13-14-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-im_megakaryocyte2_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FAM157C MARCHF2 DAPP1 PLEK	3.49e-04	165	90	4	d2ab667ff53f538b12ee4e07ea4b4d118600a228
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B4 CENPE PLEK RRM1	3.49e-04	165	90	4	1dcd6b8aa192baeaa1f7bb334843edab6049b96f
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-TRGV5/7_gdT\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TCP10L ATP8B4 RAPGEF6 SAMD3	3.65e-04	167	90	4	18e336faa2d2429ab49d1c6ae9bbf9923d74aa8d
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD1E ATP8B4 GK DAPP1	3.65e-04	167	90	4	ecdbfde870a2a44c44b9dd65a8737afc6fbf816c
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VRK1 CENPE CGAS TEP1	3.73e-04	168	90	4	b7cd33f5da4f37b9384fc3bd3ca01fbc790accfc
ToppCell	COVID-19-Myeloid-MoAM5,_CCL3L1\|Myeloid / Condition, Lineage and Cell class	TCP10L GK STK38L TP53BP2	3.73e-04	168	90	4	ea465152ea31391b63c02425beafa9a4f51f6703
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GK PLEK RYR1 TIAM2	3.73e-04	168	90	4	4b5be7c6662eceddf90a65015f12908278d1664e
ToppCell	droplet-Bladder-nan-24m-Hematologic-granulocyte-monocyte_progenitor\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ATP8B4 PLEK RYR1	3.73e-04	168	90	4	c6e0daa790dd5db20dd1ab8c1e7142484976d743
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GK PLEK RYR1 TIAM2	3.73e-04	168	90	4	689c41f6e9f65381570991cc311cba49a57ec955
ToppCell	droplet-Lung-nan-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GK PLEK RYR1 TIAM2	3.82e-04	169	90	4	ba023ee7bb165c2bfbefc2d969ff32ca1eeed33b
ToppCell	droplet-Lung-nan-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GK PLEK RYR1 TIAM2	3.82e-04	169	90	4	c96e0f3241d13926dbee9f91c0c8c5bfa7479a0d
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP3 FBXL13 MYO5A SPTA1	3.82e-04	169	90	4	c5015ddb838849ea892a2cae5a739b554eb6d793
ToppCell	PCW_10-12-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-im_megakaryocyte2_(17)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FAM157C MARCHF2 DAPP1 PLEK	3.90e-04	170	90	4	3886a77bc3ddbeb42a8149b759fe578871676d6e
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VRK1 CENPE CGAS TEP1	3.90e-04	170	90	4	9e94fa0d05abed3438b28296a293767096d517d6
ToppCell	facs-Marrow-T-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F VPS13C IKBKB TIAM2	3.90e-04	170	90	4	a78d9789c3e7c84a36e1bd380192d7aba4a4d443
Drug	Selegiline hydrochloride [14611-52-0]; Up 200; 17.8uM; MCF7; HT_HG-U133A	SP100 CD1E PRDM9 ACACB SPTA1 PCLO PCSK6 RYR2	9.06e-07	193	89	8	4146_UP
Drug	chloro-m-cresol	CACNA1S RYR1 RYR2	1.15e-06	6	89	3	CID000012008
Drug	NSC114784	CACNA1S RYR1 RYR2	1.15e-06	6	89	3	CID000419425
Drug	CNS 1145	CACNA1F CACNA1S RYR1 RYR2	8.18e-06	33	89	4	CID000190902
Drug	IHC-64	CACNA1F CACNA1S RYR1 RYR2	8.18e-06	33	89	4	CID000162753
Drug	estradiol, USP; Up 200; 0.01uM; MCF7; HT_HG-U133A	CD1E ABCA2 PCLO PCSK6 CPT1B CNOT3 RYR1	1.36e-05	200	89	7	5601_UP
Drug	FPL 64176	CACNA1S RYR1 RYR2	2.54e-05	15	89	3	CID000003423
Drug	etridiazole	MYO5A SPTA1 RYR1 RYR2	4.38e-05	50	89	4	CID000017432
Drug	methylcoumarin	CACNA1S RYR1 RYR2	4.52e-05	18	89	3	CID000007092
Drug	cis-diammineplatinum(II	RYR1 RYR2	4.52e-05	3	89	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR2	4.52e-05	3	89	2	CID002750949
Drug	8N3-cADPR	RYR1 RYR2	4.52e-05	3	89	2	CID000127713
Drug	aminodantrolene	RYR1 RYR2	4.52e-05	3	89	2	CID009570289
Drug	2-hydroxycarbazole	RYR1 RYR2	4.52e-05	3	89	2	CID000093551
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2	4.52e-05	3	89	2	CID005748312
Drug	Wang resin	DST SPTA1	4.52e-05	3	89	2	CID000070043
Drug	Cinildipine	CACNA1F CACNA1S RYR1 RYR2	6.86e-05	56	89	4	CID000002752
Drug	nilvadipine	CACNA1F CACNA1S RYR1 RYR2	9.00e-05	60	89	4	CID000004494
Drug	PCB74	RYR1 RYR2	9.02e-05	4	89	2	CID000036218
Drug	148504-47-6	RYR1 RYR2	9.02e-05	4	89	2	CID006444275
Drug	SC 38249	RYR1 RYR2	9.02e-05	4	89	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR2	9.02e-05	4	89	2	CID000035682
Drug	IAA-94	CACNA1F CACNA1S RYR1 RYR2	9.60e-05	61	89	4	CID000003667
Drug	NSC325316	NFIA NFIX DNAJC2	9.66e-05	23	89	3	CID000331608
Drug	AC1NBU2S	CACNA1F CACNA1S IKBKB RYR1 RYR2	9.68e-05	117	89	5	CID004473765
Drug	Azlocillin sodium salt [37091-65-9]; Up 200; 8.2uM; MCF7; HT_HG-U133A	SP100 PCSK6 PTPN21 IKBKB STK38L SUV39H2	1.02e-04	190	89	6	3468_UP
Drug	Ethisterone [434-03-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	CCNT2 ABCA2 PTPN21 PLEK CNOT3 SENP5	1.02e-04	190	89	6	4340_DN
Drug	lercanidipine	CACNA1F CACNA1S RYR1 RYR2	1.09e-04	63	89	4	CID000065866
Drug	(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; PC3; HT_HG-U133A	FAM13A ACACB KDM4C SETD4 IKBKB SENP5	1.14e-04	194	89	6	4524_DN
Drug	Xylazine [7361-61-7]; Up 200; 18.2uM; HL60; HT_HG-U133A	MSX2 ABCA2 PCSK6 MARCHF2 RYR1 RYR2	1.18e-04	195	89	6	2132_UP
Drug	Phenylpropanolamine hydrochloride [154-41-6]; Up 200; 21.4uM; MCF7; HT_HG-U133A	SP100 PRDM9 PCSK6 PTPN21 PLEK IKBKB	1.18e-04	195	89	6	3217_UP
Drug	Methacholine chloride [62-51-1]; Up 200; 20.4uM; MCF7; HT_HG-U133A	CD1E ACACB DDX54 DAPP1 PTPN21 STK38L	1.18e-04	195	89	6	3452_UP
Drug	Clorsulon [60200-06-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A	CCNT2 ABCA2 VPS13C PCSK6 MARCHF2 IKBKB	1.21e-04	196	89	6	7025_UP
Drug	Nizatidine [76963-41-2]; Up 200; 12uM; PC3; HT_HG-U133A	MSX2 ABCA2 PHF14 PTPN21 IKBKB TEP1	1.21e-04	196	89	6	6305_UP
Drug	Cefazolin sodium salt [27164-46-1]; Up 200; 8.4uM; HL60; HT_HG-U133A	CACNA1S ABCA2 FAM13A ACACB EXPH5 PCSK6	1.24e-04	197	89	6	2564_UP
Drug	PNU-0230031 [267429-39-0]; Down 200; 10uM; MCF7; HT_HG-U133A	ABCA2 ACACB SUGP2 KDM4C PCSK6 DAPP1	1.24e-04	197	89	6	3629_DN
Drug	Cephapirin sodium salt [24356-60-3]; Up 200; 9uM; MCF7; HT_HG-U133A	ACACB KDM4C EXPH5 DAPP1 STK38L RYR1	1.24e-04	197	89	6	3471_UP
Drug	prochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A	CCNT2 EXPH5 PCSK6 DDX54 SETD4 ABLIM3	1.24e-04	197	89	6	1640_DN
Drug	Streptomycin sulfate [3810-74-0]; Down 200; 2.8uM; MCF7; HT_HG-U133A	B4GALT7 CLMN EXPH5 DAPP1 PTPN21 STK38L	1.24e-04	197	89	6	7194_DN
Drug	Famotidine [76824-35-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A	CCNT2 CACNA1S PTPRM EXPH5 VPS13C RYR1	1.28e-04	198	89	6	1529_UP
Drug	Omeprazole [73590-58-6]; Down 200; 11.6uM; PC3; HT_HG-U133A	SP100 B4GALT7 ACACB NFIX POLE IKBKB	1.28e-04	198	89	6	6606_DN
Drug	Sulfasalazine [599-79-1]; Down 200; 10uM; MCF7; HT_HG-U133A	ABCA2 B4GALT7 DAPP1 PHF14 PTPN21 CPT1B	1.28e-04	198	89	6	2882_DN
Drug	topiramate; Up 200; 3uM; MCF7; HT_HG-U133A_EA	CCNT2 SP100 ABCA2 ZNF268 DAPP1 PTPN21	1.28e-04	198	89	6	915_UP
Drug	nordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A	MSX1 ABCA2 B4GALT7 MARCHF2 DDX54 TP53BP2	1.32e-04	199	89	6	6942_DN
Drug	Ondansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; HL60; HT_HG-U133A	ACACB EXPH5 E2F2 ABLIM3 CNOT3 RYR2	1.32e-04	199	89	6	6153_UP
Drug	Clioquinol [130-26-7]; Down 200; 13uM; MCF7; HT_HG-U133A	ABCA2 SUGP2 IKBKB TEP1 STK38L ABLIM3	1.32e-04	199	89	6	5623_DN
Drug	Benoxinate hydrochloride [5987-82-6]; Up 200; 11.6uM; MCF7; HT_HG-U133A	ACACB PCSK6 PLEK CPT1B CNOT3 RYR1	1.32e-04	199	89	6	4115_UP
Drug	Cephalothin sodium salt [58-71-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	CCNT2 SP100 ACACB KDM4C PCSK6 TEP1	1.32e-04	199	89	6	6079_DN
Drug	bepridil	CACNA1F CACNA1S PLEK RYR1 RYR2	1.37e-04	126	89	5	CID000002351
Drug	gallopamil	CACNA1F CACNA1S RYR1 RYR2	1.39e-04	67	89	4	CID000001234
Drug	A 68930	RYR1 RYR2	1.50e-04	5	89	2	ctd:C065380
Drug	4'-deoxydoxorubicin	STUB1 RYR2	1.50e-04	5	89	2	CID000044554
Drug	AC1L2AC7	CACNA1F CACNA1S RYR1 RYR2	1.55e-04	69	89	4	CID000068733
Drug	AC1L1IZ2	GK MYO1C MYO5A RRM1 DYNC1H1 RYR1 RYR2	1.91e-04	304	89	7	CID000004795
Drug	CAS 298-57-7	CACNA1F CACNA1S RYR1 RYR2	1.93e-04	73	89	4	CID000002761
Drug	ethosuximide	CACNA1F CACNA1S RYR1 RYR2	2.04e-04	74	89	4	CID000003291
Drug	MBED	RYR1 RYR2	2.24e-04	6	89	2	CID000129958
Drug	AC1O528X	RYR1 RYR2	2.24e-04	6	89	2	CID006475857
Disease	Malignant hyperthermia, susceptibility to	CACNA1S RYR1	9.20e-06	2	90	2	cv:C5437603
Disease	Malignant hyperthermia	CACNA1S RYR1	9.20e-06	2	90	2	cv:C5779784
Disease	Malignant hyperpyrexia due to anesthesia	CACNA1S RYR1	9.20e-06	2	90	2	C0024591
Disease	malignant hyperthermia (is_implicated_in)	CACNA1S RYR1	2.75e-05	3	90	2	DOID:8545 (is_implicated_in)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	2.75e-05	3	90	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	2.75e-05	3	90	2	DOID:8545 (implicated_via_orthology)
Disease	Rare disease with malignant hyperthermia	CACNA1S RYR1	5.50e-05	4	90	2	cv:C5681128
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1F CACNA1S	5.50e-05	4	90	2	DOID:0060173 (implicated_via_orthology)
Disease	fasting blood glucose measurement, glucose tolerance test, fasting blood insulin measurement	VPS13C MTNR1B	9.15e-05	5	90	2	EFO_0004307, EFO_0004465, EFO_0004466
Disease	Epidermolysis Bullosa Simplex	DST EXPH5	9.15e-05	5	90	2	C0079298
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1F CACNA1S STUB1	1.82e-04	36	90	3	DOID:11723 (implicated_via_orthology)
Disease	epidermolysis bullosa simplex (is_implicated_in)	DST EXPH5	1.91e-04	7	90	2	DOID:4644 (is_implicated_in)
Disease	Uterine leiomyoma, estrogen-receptor negative breast cancer	EXPH5 DDX10	4.07e-04	10	90	2	EFO_1000650, HP_0000131
Disease	Congenital myopathy (disorder)	CACNA1S RYR1	5.95e-04	12	90	2	C0270960
Disease	Glaucoma, Primary Open Angle	WDR36 TP53BP2	7.02e-04	13	90	2	C0339573
Disease	5-methyluridine (ribothymidine) measurement	PCLO CPT1B	8.17e-04	14	90	2	EFO_0020013
Disease	Pontoneocerebellar hypoplasia	VRK1 PCLO	1.07e-03	16	90	2	cv:C1261175
Disease	diabetic nephropathy	VRK1 PCSK6 MTNR1B SORCS3	1.17e-03	150	90	4	EFO_0000401
Disease	Antihistamine use measurement	WDR36 STAT6	1.21e-03	17	90	2	EFO_0009943
Disease	glucose homeostasis measurement, acute insulin response measurement	PTPRM MTNR1B	1.36e-03	18	90	2	EFO_0006831, EFO_0006896
Disease	colorectal cancer, inflammatory bowel disease	BMP3 ATP8B4	1.52e-03	19	90	2	EFO_0003767, MONDO_0005575
Disease	advanced glycosylation end product-specific receptor ligand measurement	FAM13A TRIM38	1.86e-03	21	90	2	EFO_0010762
Disease	progression free survival, ovarian serous carcinoma	MSX1 ABCA13	2.04e-03	22	90	2	EFO_0004920, EFO_1001516
Disease	mental or behavioural disorder	PTPRM KDM4C VPS13C SORCS3	2.23e-03	179	90	4	EFO_0000677
Disease	insular cortex volume measurement	FAM13A VPS13C	2.23e-03	23	90	2	EFO_0010309
Disease	Autism Spectrum Disorders	MTNR1B RYR2 DIPK2B	2.26e-03	85	90	3	C1510586
Disease	response to perphenazine	CLMN DAPP1	2.85e-03	26	90	2	GO_0097334

Protein segments in the cluster

Peptide	Gene	Start	Entry
DRLALWKRNELKKQA	ABLIM3	666	O94929
LKKARRKQWIEPRNC	BMP3	356	P12645
KTPNRLKKIRNWRAN	CCNT2	246	O60583
LKKIRNWRANQAARK	CCNT2	251	O60583
KAKNLKRLWVERSNT	ABCA13	131	Q86UQ4
LSDQIRRWQKAQKKA	ATP8B4	1096	Q8TF62
WKKNVRLQGLHRLQK	DNHD1	376	Q96M86
LLALWRVERKQLKNI	ADCY10	101	Q96PN6
RKTERFQKWLQAKRL	DIPK2B	146	Q9H7Y0
QNWLSAKVRKQLRLK	CGAS	341	Q8N884
WIEKQNRATRAQRKK	DNAJC2	246	Q99543
NELRDRLWKKKAALQ	TP53BP2	306	Q13625
RLWKKKAALQQKENL	TP53BP2	311	Q13625
EIKKLQRLRDQIKTW	CNOT3	51	O75175
EVKQKWASRLLAKLR	NFIA	66	Q12857
RLWKLRVLQAEVKIN	ACACB	1621	O00763
ANQELRIVIKKIWKR	CACNA1F	1546	O60840
KFIWNQKRARIAKSI	nan	846	O00370
EIKQKWASRLLAKLR	NFIX	66	Q14938
NAKKLRRKEQLWEKL	NOP53	141	Q9NZM5
KPNWIERQLLKARKL	KIAA0825	1081	Q8IV33
EWRKTNQKVRLKIRE	MARCHF2	206	Q9P0N8
AVKLRWLLDNVRKVQ	GK3P	151	Q14409
KTVVRLQEKRQKELW	IKBKB	641	O14920
LQEKRQKELWNLLKI	IKBKB	646	O14920
ARWKTLNKKVAQRAA	DST	5371	Q03001
LRIWVLVLQARRKAK	MTNR1B	221	P49286
PAWRKRDQKRIAAQK	B4GALT7	261	Q9UBV7
GRQQLKWDRKKKRFV	DDX54	726	Q8TDD1
KVDLRKRIVNWHKLL	PCLO	5121	Q9Y6V0
KWLQQQEVKRRVKRQ	PCSK6	136	P29122
RQLQRLLWTACKKKE	PPM1N	6	Q8N819
WRVILLRNYQKSKVK	FBXO48	101	Q5FWF7
RIQISLWPRKQKRRK	FAM157C	96	P0CG43
VKAWLQRRRKVRKAS	KDM4C	356	Q9H3R0
KLWRKININESAKII	KIAA0408	51	Q6ZU52
KLQKTKRDIRWLQGV	EXPH5	41	Q8NEV8
KKKWQLQARQRLARR	POLE	1276	Q07864
LKWTNDLAKFRRQLK	FAM13A	706	O94988
RKEFDVKQILKIRWR	KLHL5	51	Q96PQ7
WQKRYASRLIKLKQQ	HELZ	211	P42694
RLDRKWKRKNYLALQ	PHF14	501	O94880
KLRNLQKKRDRESCW	HIDE1	146	A8MVS5
KQNQRRWVDLEKPLK	PTPN21	71	Q16825
EQAKQLRKRNWEALK	PRPF40A	521	O75400
IKERSKLLNKRTWQR	PRDM9	456	Q9NQV7
EAIKRLLVRNWFINK	OR5T1	311	Q8NG75
WIKNRVLKKWKTRLN	CD1E	371	P15812
LIRKKAKNNIQWVGR	E2F2	181	Q14209
ANEELRAIIKKIWKR	CACNA1S	1486	Q13698
IAKKKRWNSIEERRI	STUB1	141	Q9UNE7
IKILRWKLSQIRKQL	DAPP1	251	Q9UN19
AVKLRWLLDNVRKVQ	GK	151	P32189
QLQLLLWKNVTLKRR	ABCA2	6	Q9BZC7
QLKKWKNRLILKRAA	FBXL13	116	Q8NEE6
LNKWQALLVQIRKAR	DYNC1H1	1076	Q14204
QLRKQLKKPEWQVER	DDX10	36	Q13206
SKSKLKVKRQRQQRW	H1-9P	181	P60008
KKAVWHKLLSKQRRR	RYR1	3616	P21817
VWHKLLSKQRKRAVV	RYR2	3586	Q92736
QELKAKRKRRVTWCL	CENPE	411	Q02224
INSWKKRLIRIKNGI	CPT1B	36	Q92523
KRSFLKLIRQVDKWQ	PTPRM	1361	P28827
EVKIAIRRLWSKKEN	OR4B1	291	Q8NGF8
VKIWFQNRRAKAKRL	MSX2	186	P35548
TKWKEKVQIQRQKIR	TRIM38	166	O00635
ACAAKAKWRQVVLQK	RAPGEF6	521	Q8TEU7
KRKAETWKKNRRQLA	STK38L	266	Q9Y2H1
EKLRALQLQRWKARK	TCP10L	91	Q8TDR4
LQLQRWKARKKSAAS	TCP10L	96	Q8TDR4
VKIWFQNRRAKAKRL	MSX1	216	P28360
WRKDIGNVIKRALVK	SORCS3	1021	Q9UPU3
VKQILARSKALQWTK	SAMD3	131	Q8N6K7
LLKQGHRRKNWKVRK	PLEK	251	P08567
LRKWLKARKFQDSNL	SETD4	36	Q9NVD3
QIKFEKDLRRIWLKA	AURKAIP1	166	Q9NWT8
QRKAIKALLAWVQRK	CLMN	186	Q96JQ2
RQKAVVKPQRIWTKR	PGBD2	101	Q6P3X8
KVCKLRKAQRSWVQK	SENP5	256	Q96HI0
QKQKSRRIEKVLEWL	ZNF268	51	Q14587
QLKREKLRVHKARQW	TEP1	631	Q99973
VQKERKLELVARRKW	TIAM2	521	Q8IVF5
KQGRVRKVVKAQQLW	RRM1	376	P23921
EAAKALVLKRIQIWK	STAT6	191	P42226
YIVKKAKQRIALQRW	SUV39H2	126	Q9H5I1
LRKKLWLKIARHVVQ	VPS18	751	Q9P253
RKHLTLNNKVQKKRW	SP100	556	P23497
AVRNLKKKLLPWQRR	SUGP2	666	Q8IX01
QQWRLKVLVRLSKFL	TEX10	221	Q9NXF1
KRQWNLRLDVKKNPV	VPS13C	2346	Q709C8
QRVLDRWKALKAQLI	SPTA1	1476	P02549
RWKALKAQLIDERTK	SPTA1	1481	P02549
AKPEQIQKWIRTRKL	VRK1	91	Q99986
QRRNKDVLAWVKKRR	TAPR1	121	Q14CZ0
KRWIQLFKVITNLVK	UBE3C	596	Q15386
RWKNLLNLDVIKKKN	WDR36	761	Q8NI36
LEQRKRWVKAKELAV	GARIN5B	666	Q8N5Q1
KAAKRKWAAQTIRRL	MYO1C	776	O00159
IRIQKTIRGWLLRKK	MYO5A	771	Q9Y4I1