Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS17 ADAMTS9 ADAMTS19

7.34e-05120143GO:0004222
GeneOntologyMolecularFunctionendopeptidase activity

ADAMTS17 BACE1 ADAMTS9 ADAMTS19

1.79e-04430144GO:0004175
GeneOntologyMolecularFunctionmetallopeptidase activity

ADAMTS17 ADAMTS9 ADAMTS19

3.32e-04200143GO:0008237
GeneOntologyMolecularFunctionpeptidase activity

ADAMTS17 BACE1 ADAMTS9 ADAMTS19

8.78e-04654144GO:0008233
GeneOntologyMolecularFunctionamide binding

LRP1 BACE1 IGF1R

1.07e-03299143GO:0033218
GeneOntologyMolecularFunctionamyloid-beta binding

LRP1 BACE1

2.26e-03102142GO:0001540
GeneOntologyBiologicalProcesscellular response to amyloid-beta

LRP1 BACE1 IGF1R

3.54e-0649133GO:1904646
GeneOntologyBiologicalProcessresponse to amyloid-beta

LRP1 BACE1 IGF1R

6.89e-0661133GO:1904645
GeneOntologyBiologicalProcesspositive regulation of axon regeneration

LRP1 IGF1R

4.96e-0517132GO:0048680
GeneOntologyBiologicalProcesspositive regulation of neuron projection regeneration

LRP1 IGF1R

5.58e-0518132GO:0070572
GeneOntologyBiologicalProcessextracellular matrix organization

ADAMTS17 LRP1 ADAMTS9 ADAMTS19

6.89e-05377134GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

ADAMTS17 LRP1 ADAMTS9 ADAMTS19

6.96e-05378134GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

ADAMTS17 LRP1 ADAMTS9 ADAMTS19

7.04e-05379134GO:0045229
GeneOntologyBiologicalProcesstranscytosis

LRP1 IGF1R

1.00e-0424132GO:0045056
GeneOntologyBiologicalProcessregulation of axon regeneration

LRP1 IGF1R

2.82e-0440132GO:0048679
GeneOntologyBiologicalProcessamyloid-beta clearance

LRP1 IGF1R

2.82e-0440132GO:0097242
GeneOntologyBiologicalProcesscardiac chamber development

LRP1 ADAMTS19 IGF1R

2.84e-04212133GO:0003205
GeneOntologyBiologicalProcessaorta morphogenesis

LRP1 ADAMTS9

2.97e-0441132GO:0035909
GeneOntologyBiologicalProcessregulation of neuron projection regeneration

LRP1 IGF1R

3.90e-0447132GO:0070570
GeneOntologyBiologicalProcessheart valve morphogenesis

ADAMTS9 ADAMTS19

7.01e-0463132GO:0003179
GeneOntologyBiologicalProcessprotein polyubiquitination

IRF2BP1 RNF213 FBXL7

7.02e-04289133GO:0000209
GeneOntologyBiologicalProcessaxon regeneration

LRP1 IGF1R

8.40e-0469132GO:0031103
GeneOntologyBiologicalProcessheart development

LRP1 ADAMTS9 ADAMTS19 IGF1R

9.87e-04757134GO:0007507
GeneOntologyBiologicalProcessheart valve development

ADAMTS9 ADAMTS19

1.07e-0378132GO:0003170
GeneOntologyBiologicalProcessaorta development

LRP1 ADAMTS9

1.13e-0380132GO:0035904
GeneOntologyBiologicalProcessneuron projection regeneration

LRP1 IGF1R

1.16e-0381132GO:0031102
GeneOntologyBiologicalProcesscirculatory system development

LRP1 ADAMTS9 ADAMTS19 RNF213 IGF1R

1.33e-031442135GO:0072359
GeneOntologyBiologicalProcessartery morphogenesis

LRP1 ADAMTS9

1.49e-0392132GO:0048844
GeneOntologyBiologicalProcesspositive regulation of response to wounding

LRP1 IGF1R

1.52e-0393132GO:1903036
GeneOntologyBiologicalProcessresponse to axon injury

LRP1 IGF1R

1.93e-03105132GO:0048678
DomainADAM_spacer1

ADAMTS17 ADAMTS9 ADAMTS19

5.89e-0723143IPR010294
DomainADAM_spacer1

ADAMTS17 ADAMTS9 ADAMTS19

5.89e-0723143PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS17 ADAMTS9 ADAMTS19

6.72e-0724143IPR013273
DomainPep_M12B_propep

ADAMTS17 ADAMTS9 ADAMTS19

3.02e-0639143PF01562
DomainPeptidase_M12B_N

ADAMTS17 ADAMTS9 ADAMTS19

3.02e-0639143IPR002870
DomainDISINTEGRIN_1

ADAMTS17 ADAMTS9 ADAMTS19

3.26e-0640143PS00427
DomainReprolysin

ADAMTS17 ADAMTS9 ADAMTS19

3.26e-0640143PF01421
DomainADAM_MEPRO

ADAMTS17 ADAMTS9 ADAMTS19

3.26e-0640143PS50215
DomainDISINTEGRIN_2

ADAMTS17 ADAMTS9 ADAMTS19

3.26e-0640143PS50214
DomainPeptidase_M12B

ADAMTS17 ADAMTS9 ADAMTS19

3.26e-0640143IPR001590
DomainCYSTEINE_SWITCH

ADAMTS17 ADAMTS9 ADAMTS19

3.51e-0641143PS00546
DomainDisintegrin_dom

ADAMTS17 ADAMTS9 ADAMTS19

3.51e-0641143IPR001762
DomainPept_M10_metallopeptidase

ADAMTS17 ADAMTS9 ADAMTS19

4.07e-0643143IPR001818
DomainTSP_1

ADAMTS17 ADAMTS9 ADAMTS19

1.30e-0563143PF00090
DomainTSP1_rpt

ADAMTS17 ADAMTS9 ADAMTS19

1.42e-0565143IPR000884
DomainTSP1

ADAMTS17 ADAMTS9 ADAMTS19

1.42e-0565143PS50092
DomainTSP1

ADAMTS17 ADAMTS9 ADAMTS19

1.42e-0565143SM00209
Domain-

ADAMTS17 ADAMTS9 ADAMTS19

2.76e-05811433.40.390.10
DomainMetalloPept_cat_dom

ADAMTS17 ADAMTS9 ADAMTS19

2.76e-0581143IPR024079
DomainPLAC

ADAMTS17 ADAMTS19

4.72e-0514142PF08686
DomainZINC_PROTEASE

ADAMTS17 ADAMTS9 ADAMTS19

4.89e-0598143PS00142
DomainPLAC

ADAMTS17 ADAMTS19

8.86e-0519142IPR010909
DomainPLAC

ADAMTS17 ADAMTS19

8.86e-0519142PS50900
DomainADAM_Cys-rich

ADAMTS17 ADAMTS19

1.81e-0427142IPR006586
DomainACR

ADAMTS17 ADAMTS19

1.81e-0427142SM00608
DomainGrowth_fac_rcpt_

LRP1 IGF1R

5.91e-03156142IPR009030
DomainZnf_C3HC4_RING-type

IRF2BP1 RNF213

7.13e-03172142IPR018957
Domainzf-C3HC4

IRF2BP1 RNF213

1.18e-02223142PF00097
DomainZF_RING_2

RNF213 KMT2C

2.03e-02298142PS50089
DomainRING

RNF213 KMT2C

2.13e-02305142SM00184
DomainZnf_RING

RNF213 KMT2C

2.41e-02326142IPR001841
DomainL_dom-like

IGF1R FBXL7

2.43e-02328142IPR032675
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS17 ADAMTS9 ADAMTS19

3.18e-0639113MM15165
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS17 ADAMTS9 ADAMTS19

3.18e-0639113M27417
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS17 ADAMTS9 ADAMTS19

1.72e-0568113M27303
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS17 ADAMTS9 ADAMTS19

7.09e-05109113MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS17 ADAMTS9 ADAMTS19

7.49e-05111113M27416
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS17 ADAMTS9 ADAMTS19

1.59e-04143113M27275
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS17 ADAMTS9 ADAMTS19

8.18e-04250113M27554
PathwayWP_ALZHEIMERS_DISEASE

LRP1 BACE1

1.45e-0374112MM15962
Pubmed

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

LRP1 BACE1

1.50e-07214215749709
Pubmed

The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1.

LRP1 BACE1

1.50e-07214220685197
Pubmed

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.

LRP1 BACE1

9.02e-07414219251705
Pubmed

COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.

LRP1 BACE1

1.50e-06514223926111
Pubmed

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.

ADAMTS17 ADAMTS19

3.16e-06714211867212
Pubmed

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.

LRP1 BACE1

3.16e-06714217920016
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS17 ADAMTS9 ADAMTS19

3.45e-067514320637190
Pubmed

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.

ADAMTS17 ADAMTS9

9.91e-061214225770910
Pubmed

Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes.

LRP1 BACE1

1.58e-051514220468060
Pubmed

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.

ADAMTS17 ADAMTS19

2.29e-051814235503090
Pubmed

Spatiotemporal regulation of GLI target genes in the mammalian limb bud.

ADAMTS19 IGF1R PMCHL2

7.21e-0520714326238476
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

ADAMTS9 RNF213 KMT2C FBXL7

1.68e-0473614429676528
CytobandEnsembl 112 genes in cytogenetic band chr15q26

ADAMTS17 IGF1R

1.76e-03206142chr15q26
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS17 ADAMTS9 ADAMTS19

8.23e-08199350
GeneFamilyADAM metallopeptidase domain containing|CD molecules

LRP1 IGF1R

1.54e-0239492471
CoexpressionLAKE_ADULT_KIDNEY_C2_PODOCYTES

ADAMTS9 ADAMTS19 IGF1R FBXL7

3.91e-06212144M39221
CoexpressionNIKOLSKY_BREAST_CANCER_15Q26_AMPLICON

ADAMTS17 IGF1R

6.08e-0522142M1352
CoexpressionGSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_UP

IRF2BP1 ADAMTS19 PMCHL2

1.33e-04192143M5665
CoexpressionGSE4748_CTRL_VS_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_UP

KMT2C ANGEL2 IGF1R

1.50e-04200143M6477
CoexpressionNABA_ECM_REGULATORS

ADAMTS17 ADAMTS9 ADAMTS19

2.50e-04238143M3468
CoexpressionNABA_ECM_REGULATORS

ADAMTS17 ADAMTS9 ADAMTS19

2.62e-04242143MM17062
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_500

ADAMTS17 LRP1 ADAMTS19 RNF213

4.98e-05357134gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_500
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000

ADAMTS17 ADAMTS19 RNF213

5.46e-05125133gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k1_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000

ADAMTS17 LRP1 ADAMTS9 ADAMTS19 RNF213

6.37e-05773135gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlasdev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_1000

ADAMTS17 LRP1 ADAMTS9 ADAMTS19 RNF213

6.77e-05783135gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_1000
CoexpressionAtlasdev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_500

LRP1 ADAMTS9 ADAMTS19 RNF213

6.89e-05388134gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_500
CoexpressionAtlasdev gonad_e13.5_F_SupCellPrec_Sry_top-relative-expression-ranked_200

ADAMTS17 ADAMTS19 RNF213

1.24e-04165133gudmap_dev gonad_e13.5_F_SupCellPrec_Sry_200
CoexpressionAtlasFacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#5

ADAMTS17 BACE1 NR6A1

2.53e-04210133Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K5
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#5_top-relative-expression-ranked_1000

ADAMTS9 RNF213 NR6A1

3.44e-04233133gudmap_developingGonad_e12.5_ovary_k5_1000
CoexpressionAtlasFacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_500_k-means-cluster#1

ADAMTS17 NR6A1

3.68e-0447132Facebase_RNAseq_e8.5_Paraxial Mesoderm_500_K1
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#2_top-relative-expression-ranked_1000

ADAMTS17 ADAMTS19 RNF213

4.28e-04251133gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k2_1000
CoexpressionAtlasdev gonad_e13.5_F_SupCellPrec_Sry_k-means-cluster#3_top-relative-expression-ranked_200

ADAMTS17 ADAMTS19

5.42e-0457132gudmap_dev gonad_e13.5_F_SupCellPrec_Sry_k3_200
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_k-means-cluster#3_top-relative-expression-ranked_1000

ADAMTS17 BACE1 ADAMTS9

6.71e-04293133gudmap_kidney_P0_JuxtaGlom_Ren1_k3_1000
CoexpressionAtlasdev gonad_e12.5_F_VasAssMesen_MafB_k-means-cluster#4_top-relative-expression-ranked_1000

ADAMTS17 ADAMTS19 RNF213

7.26e-04301133gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_k4_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_1000

ADAMTS17 LRP1 ADAMTS19 RNF213

8.13e-04740134gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_100

ADAMTS19 RNF213

8.63e-0472132gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_100
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000

ADAMTS9 RNF213 KMT2C NR6A1

9.72e-04776134gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000

LRP1 ADAMTS9 ADAMTS19 RNF213

9.76e-04777134gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_1000
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_1000

ADAMTS9 RNF213 KMT2C NR6A1

9.81e-04778134gudmap_developingGonad_e18.5_ovary_1000
CoexpressionAtlasdev gonad_e13.5_F_SupCellPrec_Sry_top-relative-expression-ranked_100

ADAMTS17 RNF213

1.01e-0378132gudmap_dev gonad_e13.5_F_SupCellPrec_Sry_100
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000

ADAMTS9 RNF213 KMT2C NR6A1

1.06e-03795134gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_1000

ADAMTS17 LRP1 ADAMTS19 RNF213

1.07e-03797134gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_1000
CoexpressionAtlasdev gonad_e12.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

ADAMTS17 ADAMTS9 ADAMTS19 RNF213

1.10e-03803134gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_1000
CoexpressionAtlasdev gonad_e11.5_M_SupCellPrec_Sry_top-relative-expression-ranked_100

ADAMTS9 RNF213

1.14e-0383132gudmap_dev gonad_e11.5_M_SupCellPrec_Sry_100
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_500

LRP1 ADAMTS9 RNF213

1.18e-03356133gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_500
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_500

LRP1 ADAMTS9 RNF213

1.26e-03364133gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_500
CoexpressionAtlasdev gonad_e12.5_M_SertoliCell_Sox9_top-relative-expression-ranked_100

ADAMTS9 RNF213

1.29e-0388132gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_100
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_500

LRP1 ADAMTS19 RNF213

1.34e-03372133gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_500
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#2_top-relative-expression-ranked_500

ADAMTS17 ADAMTS19

1.47e-0394132gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k2_500
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#4_top-relative-expression-ranked_1000

ADAMTS9 KMT2C

1.56e-0397132gudmap_developingGonad_e18.5_epididymis_1000_k4
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS19 IGF1R FBXL7

2.49e-051871437e376831a11ee72ed87abcdac631ca46ae29c250
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

LRP1 ADAMTS19 FBXL7

2.49e-051871434ea486991f66c29728d127171a07b81404ec0b78
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS19 IGF1R FBXL7

2.53e-05188143b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

LRP1 RNF213 KMT2C

2.95e-0519814361ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADAMTS17 LRP1 FBXL7

3.04e-0520014334f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic-3|TCGA-Mesothelium / Sample_Type by Project: Shred V9

ADAMTS17 ADAMTS19

7.04e-04127142df2854bcb2708ddc13b3ca48c03887380e827790
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Intermediate_Fibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

ADAMTS17 LRP1

8.18e-04137142dd5364a1002650d21e0c83d8c701b5f7b09d1c19
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-stem_cells_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

ANGEL2 NR6A1

1.00e-03152142375c9ef88c7703a002e868645a722c35e046ef1e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS9 ADAMTS19

1.04e-03155142e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS9 ADAMTS19

1.04e-031551425a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS9 ADAMTS19

1.04e-0315514290e629681a72baacc7981b82883866a487638dbc
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

RNF213 KMT2C

1.06e-031561421545169694f686d28648a68b552c2ae606599d66
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

IGF1R NR6A1

1.10e-031591428680b054622f573a82b1625fb93c2d5db81d1034
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGF1R NR6A1

1.13e-031611420d863d7d369391dd6148e1de6d6f8033dcb8fe0f
ToppCelldroplet-Lung-30m-Hematologic-myeloid-neutrophil|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTS17 IGF1R

1.14e-031621429c9a63adb692651ea5a52cc77b02c5ce11d0ccea
ToppCelldroplet-Lung-30m-Hematologic-myeloid-neutrophil-neutrophil|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTS17 IGF1R

1.14e-031621421d29983b22f963b34e72cfd1eec328d2d7c4932f
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

ADAMTS17 LRP1

1.15e-03163142f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|E18.5-samps / Age Group, Lineage, Cell class and subclass

ADAMTS17 LRP1

1.17e-03164142519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCellEndothelial-endothelial_cell_of_bronchial_vessel|World / Lineage, Cell type, age group and donor

ADAMTS9 FBXL7

1.18e-0316514284e553d699ac56df89a77248f7308b9133e1b683
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADAMTS17 NR6A1

1.20e-03166142006ced12f69ef13ddcba5a3891ddc7c18c384863
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADAMTS17 NR6A1

1.20e-031661426bb3410e65c971acc458c472015afcec6de6e310
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADAMTS9 FBXL7

1.20e-03166142f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAMTS17 FBXL7

1.20e-0316614294636dbc039f794c735960c3425e00bdd5523602
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADAMTS17 NR6A1

1.20e-03166142ac28c8cac1e94be0c47fb862c5809c92cdaa11f3
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ADAMTS17 NR6A1

1.20e-03166142823ec03714884cb860a1260410feac8c536b6d06
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAMTS9 FBXL7

1.21e-03167142d7fe24cdc4b55a9555ce9e20699f5036b88148e9
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D122|Adult / Lineage, Cell type, age group and donor

ADAMTS9 FBXL7

1.25e-03170142a99cb3d21f8eb926886340ea99491e078e607648
ToppCellMild_COVID-19-Myeloid-MoAM5|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

ADAMTS17 NR6A1

1.25e-03170142b2daf46ab5a49590ede8f75e4240bfe6e9d8b764
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS17 NR6A1

1.27e-03171142121e63ca281ad765d76c2afb3b4d441329b47f81
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 RNF213

1.28e-03172142c8ea80042faf923b08ff03d73100533d521d73ef
ToppCellControl-Endothelial_cells-Systemic_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

ADAMTS9 FBXL7

1.28e-03172142c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel|Adult / Lineage, Cell type, age group and donor

ADAMTS9 FBXL7

1.28e-03172142ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D122|Adult / Lineage, Cell type, age group and donor

ADAMTS9 FBXL7

1.30e-03173142dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCellCOPD-Lymphoid-ILC_A|Lymphoid / Disease state, Lineage and Cell class

ADAMTS17 IGF1R

1.30e-031731424a0043b29f8ede5a74bdb38cbf2c70e12b25e130
ToppCellP15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ADAMTS17 LRP1

1.31e-031741423c47d069bd836599a8d40eae485c23d4d3487517
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 RNF213

1.31e-03174142d5c22b43531414951666ee7542a66ed9380e2d14
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 FBXL7

1.34e-031761429bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCellmetastatic_Brain-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

IRF2BP1 NR6A1

1.34e-031761429c1f255de3082b3da4bef2a9bdff710cfd48261f
ToppCellControl-Neuronal_cells|Control / group, cell type (main and fine annotations)

ADAMTS9 FBXL7

1.34e-03176142c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCellControl-Neuronal_cells-Neuronal_cells|Control / group, cell type (main and fine annotations)

ADAMTS9 FBXL7

1.34e-0317614298c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCellCOPD-Lymphoid-ILC_A|COPD / Disease state, Lineage and Cell class

ADAMTS17 IGF1R

1.34e-03176142484452cb38fe4604f0910a068361ed461b5b0c21
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 FBXL7

1.34e-031761423f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

KMT2C ANGEL2

1.36e-03177142eb0cfe8e9a91910f9979608ed47add48d98ce4dd
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS17 IQCF3

1.36e-0317714201df8ab3285fa66b4805c555cfbfc4b3b16db919
ToppCellmetastatic_Lymph_Node-Endothelial_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

ADAMTS9 FBXL7

1.36e-0317714271bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCellmetastatic_Brain-Myeloid_cells-Activated_DCs|metastatic_Brain / Location, Cell class and cell subclass

IRF2BP1 NR6A1

1.36e-03177142739496fcc4156f4d5e3de9cd21cf3856037f0678
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|368C / Donor, Lineage, Cell class and subclass (all cells)

KMT2C ANGEL2

1.37e-03178142536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D231|Adult / Lineage, Cell type, age group and donor

ADAMTS9 FBXL7

1.37e-03178142c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS9 IGF1R

1.37e-03178142cc0382b0ee1e6c76522e2c86ad1425c45debab5d
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS9 FBXL7

1.37e-031781428f31b3fac51591f7f2bcb898c07708b3e9f93a16
ToppCellCOPD-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

ADAMTS9 FBXL7

1.39e-031791429968da1adcb561d9bf167a42ab5d9de85c071c4a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS19 FBXL7

1.39e-031791427394e77e665bf16d3733df91bb12907be460ab44
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS9 FBXL7

1.39e-031791422a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

ADAMTS19 FBXL7

1.39e-03179142dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS17 LRP1

1.40e-0318014208ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(other)|COVID-19 / group, cell type (main and fine annotations)

ADAMTS9 FBXL7

1.42e-0318114226eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

ADAMTS17 LRP1

1.43e-03182142ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 RNF213

1.43e-031821424234d0cc57b5266a5e03133c75c7918abe48465e
ToppCellfacs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS17 LRP1

1.43e-03182142c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCellfacs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS17 LRP1

1.43e-03182142dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS9 FBXL7

1.43e-03182142fbd5e332df73bf7141c822fa67b76367dc962017
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS9 FBXL7

1.45e-03183142ff95382cfed592190d0636d2b750328471f82e0d
ToppCellCOVID-19-kidney-Podocyte|kidney / Disease (COVID-19 only), tissue and cell type

ADAMTS19 FBXL7

1.45e-03183142fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

RNF213 KMT2C

1.45e-031831428f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS19 FBXL7

1.45e-031831427c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS9 ADAMTS19

1.45e-03183142612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS19 FBXL7

1.45e-03183142848fc6dd129150897ee339343e83c645b6e779eb
ToppCellControl-Endothelial_cells-Pulmonary_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

ADAMTS9 FBXL7

1.45e-0318314246be9f96755c7b65aeac061d95d15abeb6466034
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS9 ADAMTS19

1.45e-03183142eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

ADAMTS9 FBXL7

1.47e-031841420f19494789f38ab1a420545e15e748ca7eb345c3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS19 FBXL7

1.47e-031841427294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellwk_20-22-Epithelial-PNS-intermediate_Schwann|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

IRF2BP1 ADAMTS9

1.47e-031841424e3ba64692868563a579902aa9c6f88cab5bce26
ToppCellCOPD-Endothelial-VE_Venous|COPD / Disease state, Lineage and Cell class

ADAMTS9 FBXL7

1.47e-0318414244d716e7ba46a1ed03f5992631289653f8fd7d5e
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ADAMTS9 FBXL7

1.48e-0318514236ce23893915f5c380cca39b2c33a516edf31c3a
ToppCelldroplet-Liver-HEPATOCYTES-1m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS9 IGF1R

1.48e-03185142742350093d90f96735dc73e3360cdd749bae63fd
ToppCellCOPD-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

ADAMTS17 ADAMTS9

1.48e-0318514223579988036fc1925992c31919750f9b3fe9f790
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

LRP1 FBXL7

1.48e-031851428f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCellControl-Lymphoid-ILC_A|Lymphoid / Disease state, Lineage and Cell class

ADAMTS17 IGF1R

1.48e-03185142520795866d44def5be3910ce8e728045c716a24d
ToppCellCOVID-19-Endothelial_cells-Systemic_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

ADAMTS9 FBXL7

1.48e-03185142f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS17 LRP1

1.48e-03185142785c55d39909fac74415f24427979691e7e694e6
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ADAMTS9 FBXL7

1.48e-031851424a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS19 KMT2C

1.48e-03185142686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS17 LRP1

1.48e-0318514297a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCellP15-Mesenchymal-mesenchymal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ADAMTS17 LRP1

1.48e-0318514246460e74cc613df9043f5404e7342aa13cc34873
ToppCellLPS_only|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS9 RNF213

1.48e-03185142a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS19 FBXL7

1.48e-03185142b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCellCOPD-Endothelial-VE_Peribronchial|World / Disease state, Lineage and Cell class

ADAMTS9 FBXL7

1.48e-031851424abe04198ab5047c211f8d09cdb9650fa52a3cd6
ToppCellP03|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ADAMTS17 IGF1R

1.48e-03185142a07dbe1f76e40734a28826423a5cc64b8e56af5e
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF1R FBXL7

1.50e-031861422cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS17 LRP1

1.50e-0318614294d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF1R FBXL7

1.50e-0318614290d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BACE1 IGF1R

1.50e-03186142f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP1 KMT2C

1.50e-0318614223b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ADAMTS17 LRP1

1.50e-0318614288e6246172d816806a498a5c1f38e699f2f5d7c2
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BACE1 IGF1R

1.50e-031861428694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCellCOPD-Endothelial-VE_Peribronchial|COPD / Disease state, Lineage and Cell class

ADAMTS9 FBXL7

1.50e-0318614223c7d0e8372a71546d687278b985f761d282f92f
ToppCelldroplet-Liver-HEPATOCYTES-1m-Mesenchymal|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS9 IGF1R

1.51e-03187142e6afbaed352310a1cb49571a2aae18be1f533c9a
ToppCell10x5'v1-week_17-19-Lymphocytic_T-T_NK-NK_T_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS17 RNF213

1.51e-031871423301e0fca8c436d136c71f1a8fd59b3bb11bdd83
ToppCelldroplet-Liver-HEPATOCYTES-1m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS9 IGF1R

1.51e-03187142b6ecf55014f246461bf1ca12f24cb4d046661fa4
ToppCellCOPD-Endothelial-VE_Arterial|World / Disease state, Lineage and Cell class

ADAMTS9 FBXL7

1.51e-03187142be42ee71d3412bb1f52593d8814de85c354a0efa
Drugtegafur

ADAMTS17 ADAMTS19 IGF1R

3.35e-0649143CID000005386
DrugKawain [500-64-1]; Up 200; 17.4uM; MCF7; HT_HG-U133A

IRF2BP1 BACE1 ADAMTS9 FBXL7

4.78e-061941442299_UP
Drugvalinomycin; Up 200; 0.1uM; PC3; HT_HG-U133A

LRP1 ANGEL2 FBXL7

1.63e-041791435962_UP
DrugHalcinonide [3093-35-4]; Up 200; 8.8uM; HL60; HT_HG-U133A

LRP1 ANGEL2 NR6A1

1.77e-041841432185_UP
DrugLetrozole [112809-51-5]; Up 200; 14uM; HL60; HT_HG-U133A

BACE1 ANGEL2 IGF1R

1.80e-041851432916_UP
DrugPempidine tartrate [546-48-5]; Down 200; 13uM; PC3; HT_HG-U133A

ANGEL2 IGF1R FBXL7

1.95e-041901434307_DN
DrugHydroxyzine dihydrochloride [2192-20-3]; Down 200; 9uM; PC3; HT_HG-U133A

LRP1 IGF1R FBXL7

2.07e-041941436660_DN
DrugPhenacetin [62-44-2]; Up 200; 22.4uM; PC3; HT_HG-U133A

LRP1 ANGEL2 NR6A1

2.13e-041961433992_UP
DrugNortriptyline hydrochloride [894-71-3]; Up 200; 13.4uM; PC3; HT_HG-U133A

IRF2BP1 LRP1 IGF1R

2.13e-041961437300_UP
Drug0179445-0000 [211246-22-9]; Up 200; 1uM; MCF7; HT_HG-U133A

ANGEL2 IGF1R FBXL7

2.16e-041971434758_UP
DrugFenbufen [36330-85-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A

IRF2BP1 IGF1R NR6A1

2.16e-041971432308_UP
DrugFinasteride [98319-26-7]; Up 200; 10.8uM; PC3; HT_HG-U133A

IRF2BP1 LRP1 ANGEL2

2.16e-041971433744_UP
DrugNeostigmine bromide [114-80-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A

ANGEL2 NR6A1 FBXL7

2.20e-041981433294_DN
DrugTiaprofenic acid [33005-95-7]; Up 200; 15.4uM; HL60; HT_HG-U133A

IRF2BP1 ANGEL2 NR6A1

2.20e-041981432492_UP
Drugnovobiocin sodium, USP; Up 200; 100uM; SKMEL5; HG-U133A

IRF2BP1 ANGEL2 NR6A1

2.20e-04198143632_UP
DrugGlycopyrrolate [596-51-0]; Up 200; 10uM; PC3; HT_HG-U133A

IRF2BP1 LRP1 FBXL7

2.20e-041981437386_UP
DrugFlunixin meglumine [42461-84-7]; Up 200; 8.2uM; PC3; HT_HG-U133A

IRF2BP1 LRP1 NR6A1

2.20e-041981434273_UP
Drugalpha-Santonin [481-06-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A

ADAMTS9 NR6A1 FBXL7

2.20e-041981434353_UP
Drug(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Up 200; 11.8uM; HL60; HT_HG-U133A

IRF2BP1 ANGEL2 NR6A1

2.20e-041981432197_UP
DrugFlumequine [42835-25-6]; Up 200; 15.4uM; PC3; HT_HG-U133A

LRP1 ANGEL2 IGF1R

2.20e-041981435104_UP
DrugTodralazine hydrochloride [3778-76-5]; Up 200; 14.8uM; PC3; HT_HG-U133A

LRP1 ANGEL2 NR6A1

2.20e-041981435087_UP
DrugSolanine alpha [20562-02-1]; Up 200; 4.6uM; MCF7; HT_HG-U133A

IRF2BP1 IGF1R NR6A1

2.23e-041991434166_UP
DrugCaptopril [62571-86-2]; Up 200; 17.2uM; MCF7; HT_HG-U133A

IRF2BP1 IGF1R FBXL7

2.23e-041991431488_UP
DrugFamotidine [76824-35-6]; Down 200; 11.8uM; PC3; HT_HG-U133A

LRP1 IGF1R FBXL7

2.23e-041991436665_DN
DrugZaprinast [37762-06-4]; Up 200; 14.8uM; MCF7; HT_HG-U133A

IRF2BP1 ANGEL2 NR6A1

2.23e-041991433226_UP
Drug0317956-0000 [391210-11-0]; Up 200; 10uM; MCF7; HT_HG-U133A

ADAMTS9 IGF1R NR6A1

2.23e-041991433966_UP
DrugNalidixic acid sodium salt hydrate; Down 200; 14.6uM; PC3; HT_HG-U133A

IRF2BP1 ANGEL2 FBXL7

2.23e-041991433668_DN
DrugBuflomedil hydrochloride [35543-24-9]; Up 200; 11.6uM; MCF7; HT_HG-U133A

IRF2BP1 ANGEL2 FBXL7

2.23e-041991433274_UP
DrugCP-320650-01 [172079-28-6]; Up 200; 1uM; PC3; HT_HG-U133A

IRF2BP1 LRP1 ANGEL2

2.26e-042001433825_UP
DrugFlunixin meglumine [42461-84-7]; Down 200; 8.2uM; PC3; HT_HG-U133A

LRP1 IGF1R FBXL7

2.26e-042001433713_DN
DrugTSPP

LRP1 BACE1

5.50e-0457142CID000024403
DrugHypochlorous Acid

LRP1 BACE1 ANGEL2

1.54e-03387143ctd:D006997
DrugIsoflurane

BACE1 IGF1R

1.81e-03104142ctd:D007530
DrugMNPA

LRP1 IGF1R

2.52e-03123142CID000001301
DrugLinuron

BACE1 IGF1R

2.73e-03128142ctd:D008044
DrugCAS 68-19-9

IGF1R NR6A1

3.49e-03145142CID000002891
DiseaseAlzheimer's disease (biomarker_via_orthology)

LRP1 BACE1 IGF1R

2.58e-0658143DOID:10652 (biomarker_via_orthology)
Diseasediabetes mellitus (implicated_via_orthology)

LRP1 IGF1R

6.75e-0526142DOID:9351 (implicated_via_orthology)
DiseaseMoyamoya disease

LRP1 RNF213

1.61e-0440142MONDO_0016820
DiseaseAlzheimer's disease (implicated_via_orthology)

LRP1 IGF1R

3.29e-0457142DOID:10652 (implicated_via_orthology)
DiseaseHeadache

LRP1 RNF213

4.14e-0464142HP_0002315
Diseasemigraine disorder, Headache

LRP1 RNF213

7.47e-0486142HP_0002315, MONDO_0005277
DiseaseAcute Confusional Senile Dementia

BACE1 IGF1R

9.88e-0499142C0546126
DiseasePresenile dementia

BACE1 IGF1R

9.88e-0499142C0011265
DiseaseAlzheimer's Disease, Focal Onset

BACE1 IGF1R

9.88e-0499142C0750900
DiseaseAlzheimer Disease, Early Onset

BACE1 IGF1R

9.88e-0499142C0750901
DiseaseAlzheimer Disease, Late Onset

BACE1 IGF1R

9.88e-0499142C0494463
DiseaseFamilial Alzheimer Disease (FAD)

BACE1 IGF1R

1.01e-03100142C0276496
DiseaseAlzheimer's Disease

BACE1 IGF1R

1.03e-03101142C0002395
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

ADAMTS9 IGF1R

1.11e-03105142DOID:9352 (implicated_via_orthology)
Diseasecortical thickness

LRP1 ADAMTS9 IGF1R FBXL7

1.49e-031113144EFO_0004840
Diseasepeak expiratory flow

ADAMTS17 LRP1 IGF1R

1.51e-03498143EFO_0009718
DiseaseAlzheimer's disease (is_implicated_in)

LRP1 BACE1

1.74e-03132142DOID:10652 (is_implicated_in)
Diseasebrain measurement, neuroimaging measurement

ADAMTS9 ADAMTS19 FBXL7

2.01e-03550143EFO_0004346, EFO_0004464
Diseaseobesity (biomarker_via_orthology)

IGF1R PMCHL2

2.16e-03147142DOID:9970 (biomarker_via_orthology)
Diseaseprostate cancer (is_marker_for)

KMT2C IGF1R

2.42e-03156142DOID:10283 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
MVCQWRCLRCLRQQH

BACE1

476

P56817
NLQRCCWNRHISSCM

ANGEL2

41

Q5VTE6
LCQDMRWYQRCCQTC

ADAMTS17

1066

Q8TE56
LCQDMRWYQRCCETC

ADAMTS19

1181

Q8TE59
LQCRQCDRWMHAVCQ

KMT2C

1101

Q8NEZ4
RQCSNGRCVSNMLWC

LRP1

2571

Q07954
YNYRCWTTNRCQKMC

IGF1R

201

P08069
LQSCIRMWQCRQCYR

IQCF3

96

P0C7M6
RMWQCRQCYRQMCNA

IQCF3

101

P0C7M6
VCPYMMQCRRLWCNN

ADAMTS9

531

Q9P2N4
TNQLCRCARVCRRWY

FBXL7

131

Q9UJT9
TLRCMLGRVYQRCWQ

PMCHL2

71

Q9BQD1
MASVQASRRQWCYLC

IRF2BP1

1

Q8IU81
NCVMSRKQRNRCQYC

NR6A1

101

Q15406
SWRLYLVNLCQRCMD

RNF213

671

Q63HN8