Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR2 RYR3

9.77e-064262GO:0005219
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR2 RYR3

2.44e-056262GO:0048763
GeneOntologyMolecularFunctionG protein-coupled receptor activity

LHCGR OR8K3 GPRC6A TSHR RXFP1 GRM1 P2RY2

1.02e-04884267GO:0004930
GeneOntologyMolecularFunctioncalmodulin binding

PHKB CAMKK1 RYR2 RYR3

2.10e-04230264GO:0005516
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR2 RYR3

2.46e-0418262GO:0015278
GeneOntologyMolecularFunctionprotein-hormone receptor activity

LHCGR TSHR

3.71e-0422262GO:0016500
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

LHCGR TSHR RXFP1

6.71e-04133263GO:0008528
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR2 RYR3

7.41e-0431262GO:0099604
GeneOntologyMolecularFunctionpeptide receptor activity

LHCGR TSHR RXFP1

7.79e-04140263GO:0001653
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR2 RYR3

8.40e-0433262GO:0005217
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

LHCGR OR8K3 GPRC6A TSHR RXFP1 GRM1 P2RY2

1.35e-031353267GO:0004888
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A6 MFSD2B MFSD1

6.51e-03296263GO:0015291
GeneOntologyMolecularFunctionhormone binding

LHCGR RXFP1

7.90e-03103262GO:0042562
GeneOntologyBiologicalProcessactivation of adenylate cyclase activity

LHCGR TSHR RXFP1

1.04e-0534263GO:0007190
GeneOntologyBiologicalProcesspositive regulation of adenylate cyclase activity

LHCGR TSHR RXFP1

1.70e-0540263GO:0045762
GeneOntologyBiologicalProcesspositive regulation of cyclase activity

LHCGR TSHR RXFP1

2.96e-0548263GO:0031281
GeneOntologyBiologicalProcesspositive regulation of lyase activity

LHCGR TSHR RXFP1

3.15e-0549263GO:0051349
GeneOntologyBiologicalProcessregulation of adenylate cyclase activity

LHCGR TSHR RXFP1

5.52e-0559263GO:0045761
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

LHCGR GRM1 P2RY2 RYR2 RYR3

7.56e-05359265GO:0006874
GeneOntologyBiologicalProcesscellular response to caffeine

RYR2 RYR3

8.35e-0511262GO:0071313
GeneOntologyBiologicalProcessregulation of cyclase activity

LHCGR TSHR RXFP1

8.82e-0569263GO:0031279
GeneOntologyBiologicalProcessregulation of lyase activity

LHCGR TSHR RXFP1

1.04e-0473263GO:0051339
GeneOntologyBiologicalProcesscalcium ion homeostasis

LHCGR GRM1 P2RY2 RYR2 RYR3

1.10e-04389265GO:0055074
GeneOntologyBiologicalProcesscellular response to purine-containing compound

RYR2 RYR3

1.38e-0414262GO:0071415
GeneOntologyBiologicalProcessregulation of cytosolic calcium ion concentration

GRM1 P2RY2 RYR2

1.58e-0484263GO:0051480
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

LHCGR MFSD2B OR8K3 GPRC6A TSHR RXFP1 GRM1 P2RY2

2.23e-041395268GO:0007186
GeneOntologyBiologicalProcesscellular response to nitrogen compound

LHCGR TSHR KBTBD2 P2RY2 RYR2 RYR3

2.84e-04752266GO:1901699
GeneOntologyBiologicalProcessresponse to caffeine

RYR2 RYR3

3.16e-0421262GO:0031000
GeneOntologyBiologicalProcesscellular response to ATP

P2RY2 RYR3

3.16e-0421262GO:0071318
GeneOntologyBiologicalProcesscalcium-mediated signaling

LHCGR GRM1 RYR2 RYR3

3.23e-04266264GO:0019722
GeneOntologyBiologicalProcessadenylate cyclase-modulating G protein-coupled receptor signaling pathway

LHCGR TSHR RXFP1 GRM1

4.25e-04286264GO:0007188
GeneOntologyBiologicalProcessnegative regulation of cytosolic calcium ion concentration

RYR2 RYR3

4.50e-0425262GO:0051481
GeneOntologyBiologicalProcessresponse to magnesium ion

RYR2 RYR3

4.50e-0425262GO:0032026
GeneOntologyBiologicalProcessintracellular chemical homeostasis

LHCGR KAT5 GRM1 P2RY2 RYR2 RYR3

6.02e-04866266GO:0055082
GeneOntologyBiologicalProcessphospholipase C-activating G protein-coupled receptor signaling pathway

LHCGR GRM1 P2RY2

6.11e-04133263GO:0007200
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

LHCGR RYR2 RYR3

8.02e-04146263GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

LHCGR RYR2 RYR3

8.18e-04147263GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

LHCGR RYR2 RYR3

8.50e-04149263GO:0051282
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

LHCGR GRM1 P2RY2 RYR2 RYR3

8.81e-04611265GO:0030003
GeneOntologyBiologicalProcesssequestering of calcium ion

LHCGR RYR2 RYR3

9.18e-04153263GO:0051208
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

LHCGR GRM1 P2RY2 RYR2 RYR3

9.54e-04622265GO:0006873
GeneOntologyBiologicalProcessinorganic ion homeostasis

LHCGR GRM1 P2RY2 RYR2 RYR3

9.54e-04622265GO:0098771
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

RYR2 RYR3

9.90e-0437262GO:0014808
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

RYR2 RYR3

1.10e-0339262GO:1903514
GeneOntologyBiologicalProcesscellular homeostasis

LHCGR KAT5 GRM1 P2RY2 RYR2 RYR3

1.16e-03981266GO:0019725
GeneOntologyBiologicalProcessresponse to ATP

P2RY2 RYR3

1.16e-0340262GO:0033198
GeneOntologyBiologicalProcesscellular response to alkaloid

RYR2 RYR3

1.16e-0340262GO:0071312
GeneOntologyBiologicalProcessresponse to purine-containing compound

P2RY2 RYR2 RYR3

1.16e-03166263GO:0014074
GeneOntologyBiologicalProcesscalcium ion transport into cytosol

LHCGR RYR2

1.28e-0342262GO:0060402
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

RYR2 RYR3

1.40e-0344262GO:0070296
GeneOntologyBiologicalProcesscarboxylic acid transport

SLC6A6 LHCGR GRM1 P2RY2

1.63e-03410264GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

SLC6A6 LHCGR GRM1 P2RY2

1.66e-03412264GO:0015849
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

LHCGR GRM1 P2RY2 RYR2 RYR3

1.67e-03705265GO:0055080
GeneOntologyBiologicalProcessadenylate cyclase-activating G protein-coupled receptor signaling pathway

LHCGR TSHR RXFP1

1.74e-03191263GO:0007189
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

LHCGR GRM1 P2RY2 RYR2 RYR3

1.79e-03717265GO:0050801
GeneOntologyBiologicalProcessicosanoid secretion

LHCGR P2RY2

2.26e-0356262GO:0032309
GeneOntologyBiologicalProcessamino acid import across plasma membrane

SLC6A6 GRM1

2.42e-0358262GO:0089718
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

LHCGR RYR2 RYR3

2.50e-03217263GO:0097553
GeneOntologyBiologicalProcessprotein localization to lysosome

LHCGR MFSD1

2.59e-0360262GO:0061462
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

LHCGR TSHR

2.67e-0361262GO:0007187
GeneOntologyBiologicalProcesspositive regulation of cytosolic calcium ion concentration

LHCGR P2RY2 RYR2

2.73e-03224263GO:0007204
DomainRR_TM4-6

RYR2 RYR3

5.59e-063262PF06459
DomainRyanrecept_TM4-6

RYR2 RYR3

5.59e-063262IPR009460
DomainRyR

RYR2 RYR3

5.59e-063262PF02026
DomainRyanodine_rcpt

RYR2 RYR3

5.59e-063262IPR003032
DomainRyan_recept

RYR2 RYR3

5.59e-063262IPR013333
DomainRIH_assoc

RYR2 RYR3

2.79e-056262PF08454
DomainGphrmn_rcpt_fam

LHCGR TSHR

2.79e-056262IPR002131
DomainRIH_assoc-dom

RYR2 RYR3

2.79e-056262IPR013662
DomainIns145_P3_rec

RYR2 RYR3

2.79e-056262PF08709
DomainRYDR_ITPR

RYR2 RYR3

2.79e-056262PF01365
DomainRIH_dom

RYR2 RYR3

2.79e-056262IPR000699
DomainIns145_P3_rcpt

RYR2 RYR3

2.79e-056262IPR014821
DomainRyanodine_recept-rel

RYR2 RYR3

2.79e-056262IPR015925
Domain-

RYR2 RYR3

2.79e-0562621.25.10.30
DomainMIR

RYR2 RYR3

8.33e-0510262PS50919
DomainMIR

RYR2 RYR3

8.33e-0510262PF02815
DomainMIR

RYR2 RYR3

8.33e-0510262SM00472
DomainLRR_5

LHCGR TSHR

8.33e-0510262PF13306
DomainLRR_5

LHCGR TSHR

8.33e-0510262IPR026906
DomainMIR_motif

RYR2 RYR3

8.33e-0510262IPR016093
DomainGPCR_3_9-Cys_dom

GPRC6A GRM1

1.44e-0413262IPR011500
DomainNCD3G

GPRC6A GRM1

1.44e-0413262PF07562
DomainGPCR_3_CS

GPRC6A GRM1

1.68e-0414262IPR017979
DomainGPCR_3

GPRC6A GRM1

3.85e-0421262IPR000337
DomainG_PROTEIN_RECEP_F3_4

GPRC6A GRM1

4.23e-0422262PS50259
Domain7tm_3

GPRC6A GRM1

4.23e-0422262PF00003
DomainGPCR_3_C

GPRC6A GRM1

4.23e-0422262IPR017978
DomainG_PROTEIN_RECEP_F3_2

GPRC6A GRM1

4.23e-0422262PS00980
DomainG_PROTEIN_RECEP_F3_3

GPRC6A GRM1

4.23e-0422262PS00981
DomainG_PROTEIN_RECEP_F3_1

GPRC6A GRM1

4.23e-0422262PS00979
DomainBTB

GMCL2 ZBTB33 KBTBD2

7.79e-04131263PF00651
DomainANF_receptor

GPRC6A GRM1

1.20e-0337262PF01094
DomainANF_lig-bd_rcpt

GPRC6A GRM1

1.20e-0337262IPR001828
DomainPeripla_BP_I

GPRC6A GRM1

1.34e-0339262IPR028082
DomainBTB

GMCL2 ZBTB33 KBTBD2

1.39e-03160263PS50097
DomainBTB

GMCL2 ZBTB33 KBTBD2

1.94e-03180263SM00225
DomainGPCR_Rhodpsn_7TM

LHCGR OR8K3 TSHR RXFP1 P2RY2

2.06e-03670265IPR017452
DomainBTB/POZ_dom

GMCL2 ZBTB33 KBTBD2

2.10e-03185263IPR000210
Domain7tm_1

LHCGR OR8K3 TSHR RXFP1 P2RY2

2.15e-03677265PF00001
DomainG_PROTEIN_RECEP_F1_1

LHCGR OR8K3 TSHR RXFP1 P2RY2

2.27e-03685265PS00237
DomainG_PROTEIN_RECEP_F1_2

LHCGR OR8K3 TSHR RXFP1 P2RY2

2.35e-03691265PS50262
DomainGPCR_Rhodpsn

LHCGR OR8K3 TSHR RXFP1 P2RY2

2.37e-03692265IPR000276
DomainSPRY

RYR2 RYR3

6.48e-0387262SM00449
DomainSPRY

RYR2 RYR3

7.53e-0394262PF00622
DomainSPRY_dom

RYR2 RYR3

7.53e-0394262IPR003877
DomainB30.2/SPRY

RYR2 RYR3

7.68e-0395262IPR001870
DomainB302_SPRY

RYR2 RYR3

7.68e-0395262PS50188
DomainLRRNT

LHCGR RXFP1

8.16e-0398262IPR000372
DomainLRRNT

LHCGR RXFP1

8.16e-0398262SM00013
Domain-

LHCGR TSHR RXFP1

9.76e-033212633.80.10.10
DomainMFS

MFSD2B MFSD1

9.84e-03108262PS50850
DomainL_dom-like

LHCGR TSHR RXFP1

1.03e-02328263IPR032675
DomainIon_trans_dom

RYR2 RYR3

1.09e-02114262IPR005821
DomainIon_trans

RYR2 RYR3

1.09e-02114262PF00520
DomainMFS_dom

MFSD2B MFSD1

1.48e-02134262IPR020846
DomainEF-hand_1

RYR2 RYR3

1.88e-02152262PF00036
PathwayWP_GPCRS_NONODORANT

LHCGR GPRC6A TSHR RXFP1 GRM1 P2RY2

2.47e-06266226MM15843
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

LHCGR PHKB GRM1 RYR2 RYR3

6.71e-06178225M2890
PathwayKEGG_MEDICUS_REFERENCE_RORA_MEDIATED_TRANSCRIPTION

KAT5 GRM1

2.32e-055222M49011
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ATXN1_TO_RORA_MEDIATED_TRANSCRIPTION

KAT5 GRM1

3.47e-056222M47665
PathwayREACTOME_GPCR_LIGAND_BINDING

LHCGR GPRC6A TSHR RXFP1 GRM1 P2RY2

3.83e-05430226MM15160
PathwayREACTOME_SIGNALING_BY_GPCR

LHCGR GPRC6A TSHR RXFP1 GRM1 CAMKK1 P2RY2

3.83e-05646227MM14962
PathwayKEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION

LHCGR TSHR RXFP1 GRM1 P2RY2

5.19e-05272225M13380
PathwayREACTOME_GPCR_LIGAND_BINDING

LHCGR GPRC6A TSHR RXFP1 GRM1 P2RY2

5.79e-05463226M507
PathwayREACTOME_SIGNALING_BY_GPCR

LHCGR GPRC6A TSHR RXFP1 GRM1 CAMKK1 P2RY2

6.51e-05702227M746
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

RYR2 RYR3

1.27e-0411222M47958
PathwayREACTOME_HORMONE_LIGAND_BINDING_RECEPTORS

LHCGR TSHR

1.52e-0412222M13070
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

RYR2 RYR3

1.79e-0413222M39589
PathwayREACTOME_HORMONE_LIGAND_BINDING_RECEPTORS

LHCGR TSHR

2.41e-0415222MM14972
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR2 RYR3

3.91e-0419222M47760
PathwayWP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA

GRM1 RYR3

5.27e-0422222M39795
PathwayWP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV

GRM1 RYR2

1.19e-0333222M39875
PathwayPID_ARF6_PATHWAY

LHCGR TSHR

1.34e-0335222M86
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

LHCGR TSHR RXFP1

1.37e-03143223MM15055
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

GPRC6A GRM1

1.50e-0337222MM15067
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

LHCGR TSHR RXFP1 P2RY2

1.55e-03330224M18334
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

LHCGR TSHR RXFP1 P2RY2

1.60e-03333224MM14963
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

GPRC6A GRM1

1.66e-0339222M793
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

RXFP1 RYR2 RYR3

1.69e-03154223MM15974
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

RXFP1 RYR2 RYR3

1.75e-03156223M39475
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

LHCGR TSHR RXFP1

1.79e-03157223M4904
PathwayWP_15Q25_COPY_NUMBER_VARIATION

GRM1 RYR2

2.31e-0346222M48105
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

LHCGR GRM1

2.72e-0350222M47951
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

LHCGR TSHR P2RY2

2.89e-03186223MM15994
PathwayREACTOME_ION_HOMEOSTASIS

RYR2 RYR3

3.17e-0354222MM15202
PathwayREACTOME_ION_HOMEOSTASIS

RYR2 RYR3

3.17e-0354222M27460
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

GPRC6A GRM1 P2RY2

4.07e-03210223MM15043
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

GPRC6A GRM1 P2RY2

4.46e-03217223M18437
PathwayWP_GPCRS_PEPTIDE

LHCGR TSHR

5.27e-0370222MM15959
Pubmed

Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding.

LHCGR TSHR

5.37e-0722621651314
Pubmed

An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.

LHCGR TSHR

5.37e-07226218162522
Pubmed

Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.

LHCGR TSHR

5.37e-0722622293030
Pubmed

The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.

RYR2 RYR3

5.37e-07226214550562
Pubmed

A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.

LHCGR TSHR

5.37e-07226211312274
Pubmed

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.

RYR2 RYR3

5.37e-07226221531043
Pubmed

Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.

RYR2 RYR3

5.37e-07226216678258
Pubmed

Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.

RYR2 RYR3

5.37e-07226214985349
Pubmed

Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies.

LHCGR TSHR

5.37e-07226222309849
Pubmed

Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.

RYR2 RYR3

5.37e-0722628898078
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR2 RYR3

1.61e-0632629242641
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR2 RYR3

1.61e-06326218403125
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR2 RYR3

1.61e-06326222948152
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR2 RYR3

1.61e-06326210788707
Pubmed

RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.

RYR2 RYR3

1.61e-06326215024040
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR2 RYR3

1.61e-06326218434746
Pubmed

Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.

RYR2 RYR3

1.61e-06326229730765
Pubmed

Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.

LHCGR TSHR

1.61e-0632628747461
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR2 RYR3

1.61e-06326225239916
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR2 RYR3

1.61e-0632627621815
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR2 RYR3

1.61e-0632629204703
Pubmed

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.

RYR2 RYR3

1.61e-06326218643873
Pubmed

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).

RYR2 RYR3

1.61e-06326211159936
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR2 RYR3

1.61e-0632627876312
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR2 RYR3

1.61e-06326221881589
Pubmed

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.

LHCGR TSHR

1.61e-06326211847099
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR2 RYR3

1.61e-06326210473538
Pubmed

Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.

RYR2 RYR3

1.61e-0632627959768
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR2 RYR3

1.61e-06326212213830
Pubmed

The organization of proteins in the human red blood cell membrane. A review.

RYR2 RYR3

1.61e-0632624600883
Pubmed

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.

RYR2 RYR3

1.61e-0632627635066
Pubmed

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.

LHCGR TSHR

1.61e-06326215889138
Pubmed

Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.

RYR2 RYR3

3.22e-0642629384575
Pubmed

A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.

RYR2 RYR3

3.22e-06426218206662
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR2 RYR3

3.22e-0642629607712
Pubmed

Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.

RYR2 RYR3

3.22e-06426223482488
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR2 RYR3

3.22e-06426223413940
Pubmed

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

SLC6A6 LHCGR RYR2 RYR3

3.82e-0614326420424473
Pubmed

Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.

RYR2 RYR3

5.37e-06526233060591
Pubmed

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

RYR2 RYR3

5.37e-06526219011160
Pubmed

KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.

ZBTB33 KAT5

5.37e-06526225288747
Pubmed

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

RYR2 RYR3

5.37e-06526223918386
Pubmed

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

RYR2 RYR3

8.05e-06626219549818
Pubmed

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

RYR2 RYR3

8.05e-06626219009018
Pubmed

Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.

RYR2 RYR3

8.05e-06626226025922
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR2 RYR3

8.05e-06626223463619
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR2 RYR3

8.05e-06626216844763
Pubmed

FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.

RYR2 RYR3

8.05e-06626214592808
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR2 RYR3

8.05e-06626220519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR2 RYR3

8.05e-06626225966694
Pubmed

Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.

GRM1 P2RY2

1.13e-05726225003238
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR2 RYR3

1.13e-05726211860456
Pubmed

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

RYR2 RYR3

1.13e-05726220962236
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

RYR2 RYR3

1.50e-05826211784029
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR2 RYR3

1.50e-05826219033399
Pubmed

Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.

LHCGR TSHR RXFP1

1.96e-057026312036966
Pubmed

The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.

GPRC6A GRM1

2.41e-051026217156446
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

RYR2 RYR3

3.53e-051226219095005
Pubmed

Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.

LHCGR TSHR

1.01e-042026220716560
Pubmed

Circular RNA profile in liver tissue of EpCAM knockout mice.

PHKB PROM1

1.23e-042226231524221
Pubmed

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.

SLC6A6 RYR2

2.01e-042826223006423
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

ZBTB33 KBTBD2 SLFN13 PI4KA RYR2

2.45e-0477726535844135
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

RYR2 RYR3

3.72e-043826230786075
Pubmed

The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.

KAT5 GRM1 PI4KA

4.35e-0419926336688959
Pubmed

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.

LHCGR TSHR P2RY2

4.42e-0420026318240029
CytobandEnsembl 112 genes in cytogenetic band chr6q22

TBC1D32 GPRC6A RNF217

5.13e-05127263chr6q22
Cytoband6q22.31

TBC1D32 RNF217

1.07e-04272626q22.31
GeneFamilyGlycoprotein hormone receptors

LHCGR TSHR

2.81e-063182199
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR2 RYR3

2.81e-063182287
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZBTB33 KBTBD2

7.72e-03134182861
GeneFamilyEF-hand domain containing

RYR2 RYR3

1.97e-02219182863
CoexpressionHOWLIN_PUBERTAL_MAMMARY_GLAND

SLC6A6 PROM1 PI4KA

3.80e-0566263M1267
CoexpressionHOWLIN_PUBERTAL_MAMMARY_GLAND

SLC6A6 PROM1 PI4KA

5.15e-0573263MM533
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RXFP1 GRM1 RYR2 RYR3

4.19e-06189264e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RXFP1 GRM1 RYR2 RYR3

4.19e-06189264b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Ptgfr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RXFP1 RYR3 SGPP2

5.45e-05127263fb58f4b4d3722f4b9a2e4946c0244c5b70dd883b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PROM1 TSHR SPINK7

6.53e-051352638521107817df49efd9a2e81078c8535ed33e729c
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Prdm8|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RXFP1 GRM1 SGPP2

9.10e-05151263090b067873740c282865e2d02cf47d5cb3dd7607
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PROM1 SLFN13 SGPP2

9.47e-05153263499670e716fc85ce76630fc813cec86f8419f2a1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A6 PROM1 RYR3

1.16e-041642631cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RXFP1 GRM1 CAMKK1

1.51e-04179263445eeb0356d9fd894aa33dd9f45d893b21424149
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RXFP1 GRM1 CAMKK1

1.58e-0418226335b2a5625323bf0917214d3b82fafc4a8f5e75ff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRM1 RYR2 RYR3

1.63e-04184263ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRM1 RYR2 RYR3

1.63e-041842632cbed6462fea2622871bb7e49b0df3d984239281
ToppCellCV-Healthy-7|CV / Virus stimulation, Condition and Cluster

PHKB SLFN13 SGPP2

1.63e-041842630e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRM1 RYR2 RYR3

1.63e-041842632b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RXFP1 GRM1 CAMKK1

1.63e-041842639a185e6ea86bbfbb48bfe88650a8c05ceba78d7f
ToppCellfacs-Bladder-nan-18m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LHCGR PROM1 RYR2

1.66e-041852633e00879466e626aa8604efecfc4678d64f54dbfc
ToppCellCV-Healthy-7|Healthy / Virus stimulation, Condition and Cluster

PHKB SLFN13 SGPP2

1.66e-041852631979d189c204f4c2893e3170a514ee7d5523406c
ToppCellfacs-Bladder-nan-18m-Epithelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LHCGR PROM1 RYR2

1.66e-041852633dc5812c961ff209f197ff4cbfb90009c0537550
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RXFP1 GRM1 RYR2

1.69e-04186263337f768cc43db2db96ba6495b076006b1a5b0331
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RXFP1 GRM1 RYR2

1.69e-04186263e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 PROM1 SGPP2

1.74e-041882634dc89c7843ebd078e3414e835c56f11fa27f0c5f
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 PROM1 SGPP2

1.74e-04188263d577b3c2a844e3062c7ca9e9ebc1722d0ac95caa
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 PROM1 SGPP2

1.74e-041882631e788b60dd643bf220d8dfafa82d85fd083cbc71
ToppCellfacs-Heart-RA-24m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RXFP1 RYR2 RYR3

1.77e-04189263e4efbb0733b382f4c855f6653dcddf36e0f8df28
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RXFP1 CAMKK1 RYR2

1.79e-0419026349e09cdb843b3d889a06a811aa5affae68b25a75
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 PROM1 SGPP2

1.85e-04192263a116db7dec495e5a0ba9c7537057cd1e567d7885
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 PROM1 SGPP2

1.85e-041922639ae05db5bfb8b9d3935c0328e6f2d489d2b1ebfd
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 PROM1 SGPP2

1.85e-0419226366defad13bd8e79319741e43ddb056841710b1d7
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

TBC1D32 RYR2 RYR3

2.03e-041982630c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCellNeuronal-Excitatory|Neuronal / cells hierarchy compared to all cells using T-Statistic

RXFP1 GRM1 RYR2

2.09e-042002634409065bc7aa995354c71e0f9d6f3726cf393d6b
Drugmyo-inositol

SLC6A6 LHCGR GPRC6A TSHR KAT5 GRM1 P2RY2 PI4KA RYR2 RYR3

9.85e-098112610CID000000892
Drug2-hydroxyheptanoic acid

RYR2 RYR3

3.76e-063262CID002750949
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR2 RYR3

3.76e-063262CID005748312
Drug8N3-cADPR

RYR2 RYR3

3.76e-063262CID000127713
Drug2-hydroxycarbazole

RYR2 RYR3

3.76e-063262CID000093551
Drugaminodantrolene

RYR2 RYR3

3.76e-063262CID009570289
Drugcis-diammineplatinum(II

RYR2 RYR3

3.76e-063262CID000159790
DrugLOPAC

PI4KA RYR2 RYR3

5.26e-0630263CID000062696
DrugM-HN

PROM1 RYR2 RYR3

5.82e-0631263CID000015450
DrugSC 38249

RYR2 RYR3

7.51e-064262CID000134834
DrugAC1L1U7A

RYR2 RYR3

7.51e-064262CID000035682
DrugPCB74

RYR2 RYR3

7.51e-064262CID000036218
Drug148504-47-6

RYR2 RYR3

7.51e-064262CID006444275
Drug1,2-dichlorohexafluorocyclobutane

GRM1 RYR2 RYR3

1.00e-0537263CID000009643
DrugOrg 41841

LHCGR TSHR

1.25e-055262ctd:C510603
DrugAspartylglutamate

LHCGR TSHR GRM1

1.27e-0540263CID000151403
DrugAC1O528X

RYR2 RYR3

1.88e-056262CID006475857
DrugNSC114784

RYR2 RYR3

1.88e-056262CID000419425
DrugMBED

RYR2 RYR3

1.88e-056262CID000129958
Drugthieno[2,3-d]pyrimidine

LHCGR TSHR

1.88e-056262CID012225304
Drugchloro-m-cresol

RYR2 RYR3

1.88e-056262CID000012008
DrugAzumoleno

RYR2 RYR3

2.62e-057262CID000056259
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR2 RYR3

2.62e-057262CID009547999
DrugBr2BAPTA

RYR2 RYR3

2.62e-057262CID003081001
DrugAC1L1KC5

KAT5 GRM1 P2RY2 PI4KA RYR2 RYR3

2.69e-05541266CID000005428
DrugAC1L1KS5

KAT5 GRM1 P2RY2 RYR2 RYR3

3.37e-05334265CID000005631
DrugD-myo-inositol-1,4,5-triphosphate

KAT5 GRM1 P2RY2 PI4KA RYR2 RYR3

3.53e-05568266CID000000806
Drugfura 2

LHCGR RYR2 RYR3

5.51e-0565263CID000057054
DrugPCB 95

RYR2 RYR3

5.61e-0510262CID000038012
Drugbaclofen

GPRC6A GRM1 RYR2 RYR3

6.21e-05191264CID000002284
DrugNO-cAMP

LHCGR TSHR RXFP1

6.59e-0569263CID006426615
DrugR 478

RYR2 RYR3

6.85e-0511262CID000084223
Drug8-amino-cADPR

RYR2 RYR3

6.85e-0511262CID003081323
DrugPCB 66

RYR2 RYR3

6.85e-0511262CID000036185
DrugFlucloxacillin sodium [1847-24-1]; Down 200; 8.4uM; PC3; HT_HG-U133A

SLC6A6 ZBTB33 KAT5 GRM1

6.86e-051962645102_DN
Drug(2S,3R)-Sphingosine

KAT5 PI4KA RYR2 RYR3 SGPP2

6.94e-05389265CID000001104
Druggadolinium

GPRC6A GRM1 RYR2 RYR3

7.28e-05199264CID000023982
DrugC070379

GRM1 P2RY2 RYR2 RYR3

7.28e-05199264CID003034747
DrugRyanodine

RYR2 RYR3

8.22e-0512262ctd:D012433
DrugXeC compound

GRM1 RYR2 RYR3

1.18e-0484263CID000005701
DrugFPL 64176

RYR2 RYR3

1.30e-0415262CID000003423
DrugGvapspat amide

RYR2 RYR3

1.30e-0415262CID000125015
Drug3-(1H-pyrrole-2-carboxylate

GRM1 P2RY2 RYR2 RYR3

1.34e-04233264CID000005114
DrugPicrotoxin

LHCGR TSHR RYR2

1.65e-0494263ctd:D010852
Drugkazinol B

RYR2 RYR3

1.69e-0417262CID000480869
Druggamma-aminobutyric acid

SLC6A6 GPRC6A GRM1 RYR2 RYR3

1.75e-04474265CID000000119
Drugborate

P2RY2 RYR2 RYR3

1.87e-0498263CID000007628
Drugmethylcoumarin

RYR2 RYR3

1.90e-0418262CID000007092
Drugindo-1

P2RY2 RYR2 RYR3

1.93e-0499263CID000105060
DrugAC1L380G

RYR2 RYR3

2.12e-0419262CID000084698
DrugAC1MW7VF

RYR2 RYR3

2.12e-0419262CID000414699
Drugindo-1/AM

RYR2 RYR3

2.60e-0421262CID000123918
Drugfluo-3

P2RY2 RYR2 RYR3

3.57e-04122263CID000104978
DrugA-26

LHCGR TSHR

3.70e-0425262CID000037120
DrugT0702

RYR2 RYR3

3.70e-0425262CID000005908
DrugKn 04

P2RY2 RYR3

4.01e-0426262CID000131117
DrugAC1L1IZE

P2RY2 RYR2 RYR3

4.39e-04131263CID000004799
DrugBAPTA

GRM1 P2RY2 RYR2 RYR3

4.70e-04324264CID000104751
DrugGTP[S]

KAT5 GRM1 P2RY2 PI4KA RYR3

4.85e-04591265CID000001764
Drug2,4-xylidinothiazoline

RYR2 RYR3

5.35e-0430262CID000099296
DrugSBFI

KAT5 GRM1

5.35e-0430262CID000123881
Drugcarboxyamidotriazole

KAT5 PI4KA

5.71e-0431262CID000108144
DrugDantrolene-13C3

GRM1 RYR2 RYR3

5.91e-04145263CID000002951
Drugnimodipine

GRM1 RYR2 RYR3

5.91e-04145263CID000004497
Drugsalicylhydroxamic acid

SPINK7 RYR2 RYR3

6.03e-04146263CID000066644
DrugM3/M4

RYR2 RYR3

6.09e-0432262CID000486507
DrugCNS 1145

RYR2 RYR3

6.48e-0433262CID000190902
DrugIHC-64

RYR2 RYR3

6.48e-0433262CID000162753
DrugCHAPS detergent

KAT5 RYR2 RYR3

7.58e-04158263CID000107670
Drugphorbol acetate myristate

LHCGR TSHR KAT5 GRM1 P2RY2 RYR2 RYR3

7.61e-041399267CID000004792
Druglidocaine

PHKB RYR2 RYR3

7.86e-04160263CID000003676
Drug4-chloro-m-cresol

RYR2 RYR3

8.15e-0437262CID000001732
Drugmag-fura-2

RYR2 RYR3

8.15e-0437262CID000123839
Drugforskolin from Coleus forskohlii

LHCGR TSHR GRM1 P2RY2 RYR2 RYR3

8.18e-041013266CID000003413
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR2 RYR3

2.24e-063262DOID:8545 (implicated_via_orthology)
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR2 RYR3

2.24e-063262DOID:3529 (implicated_via_orthology)
DiseaseTourette syndrome

TSHR SGPP2

8.91e-0450262EFO_0004895
Diseaseplatelet crit

MFSD2B PHKB GMCL2 KAT5 P2RY2

1.29e-03952265EFO_0007985
Diseasesmooth surface dental caries

PROM1 TSHR

1.37e-0362262EFO_0006339
Diseaseacute lymphoblastic leukemia

RXFP1 RYR2

1.55e-0366262EFO_0000220

Protein segments in the cluster

PeptideGeneStartEntry
CVFLGPDYQVYICIA

TBC1D32

1181

Q96NH3
VVAFFIICACYIKIY

LHCGR

536

P22888
LIVDGRVYYICIVCK

ZBTB33

486

Q86T24
VTLYCFVYGKCPFID

CAMKK1

341

Q8N5S9
TLPVLYLCEFCLKYG

KAT5

256

Q92993
IKPSLVCCEGYIYAI

KBTBD2

371

Q8IY47
KEYLCKYAIPCLIGI

PI4KA

176

P42356
IICVCYYVAVFPFIG

MFSD1

271

Q9H3U5
YCIAAAVVVVTYPVC

MFSD2B

231

A6NFX1
FKYVLLPVSYGVVCV

P2RY2

31

P41231
LYCTFIPKCYVIICK

GPRC6A

826

Q5T6X5
DCSIYKKYPVVAIPC

SPINK7

31

P58062
CYIILAGIFLGYVCP

GRM1

631

Q13255
VISFFCIIGYYCLKV

RYR2

4581

Q92736
CIIGYYCLKVPLVIF

RYR2

4586

Q92736
VFCGKELYGYLCVIK

SLFN13

301

Q68D06
YRILGKTVVCYPIIF

PHKB

566

Q93100
CVGCFIFSLVKYVPL

SLC6A6

516

P31641
YICCNFLYISPEKGI

GMCL2

501

Q8NEA9
KIVYYEAGIILCCVL

PROM1

101

O43490
VVIGLFVFPIYCLCK

RNF217

516

Q8TC41
CQVLVAIPYLYCTFI

OR8K3

141

Q8NH51
VCVIVVPFFLCYNYP

SGPP2

251

Q8IWX5
IISLVCVVGYYCLKV

RYR3

4486

Q15413
CVVGYYCLKVPLVVF

RYR3

4491

Q15413
LTLEKYICIVYPFRC

RXFP1

506

Q9HBX9
PFVVYCQYKEPLLEC

TRMT6

396

Q9UJA5
IVAFVIVCCCYVKIY

TSHR

591

P16473