Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainPapD-like

VAPB CFAP65 TMEM131

2.11e-0591203IPR008962
DomainDUF3480

ZFYVE16 ZFYVE9

4.09e-0521202PF11979
DomainDUF3480

ZFYVE16 ZFYVE9

4.09e-0521202IPR022557
DomainZnf_FYVE_endofin

ZFYVE16 ZFYVE9

4.09e-0521202IPR017165
DomainSynaptophysin/porin

SYNPR SYPL2

2.44e-0441202IPR001285
DomainTLDc

TBC1D24 NCOA7

4.04e-0451202SM00584
DomainMSP_dom

VAPB CFAP65

6.04e-0461202IPR000535
DomainTLDc_dom

TBC1D24 NCOA7

6.04e-0461202IPR006571
DomainhnRNP_C

HNRNPCL1 HNRNPCL4

6.04e-0461202IPR017347
DomainMSP

VAPB CFAP65

6.04e-0461202PS50202
DomainTLD

TBC1D24 NCOA7

6.04e-0461202PF07534
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RANBP2 HNRNPCL1 RAE1 NUP58 HNRNPCL3

3.90e-0558935MM15149
Pubmed

Interaction network of human early embryonic transcription factors.

RANBP2 TSHZ3 RAE1 C15orf39 NUP58 RFX7 EMSY MED15 ZFHX4 TLE1 ASXL3 ATF3 MED12

4.53e-103511241338297188
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RANBP2 TSHZ3 IRS4 ZFYVE16 DVL2 C15orf39 RB1CC1 DCTN1 ZFHX4 TLE1 PLEKHA5 MED12

3.68e-084181241234709266
Pubmed

Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.

HNRNPCL1 HNRNPCL3 PER2

1.53e-067124325846207
Pubmed

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

MED15 MED12 MED13

5.21e-0610124323746844
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

VAPB FKBP15 RANBP2 DPYSL2 IRS4 CAND1 ZFYVE16 DVL2 DCTN1 EMSY BRAP AHCY COPS4 NCOA7

6.51e-069341241433916271
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CACNA1E FKBP15 DLGAP2 RANBP2 DPYSL2 CAND1 DVL2 MPDZ DCTN1 EMSY OTUD4 PLEKHA5 HERC2 UNC79

9.18e-069631241428671696
Pubmed

Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation.

PTCH1 HMX2 GLI2

9.51e-0612124338602877
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

RANBP2 CAND1 RAE1 EIF4A3 DACH1 C15orf39 EMSY MED15 ZC3H10 CELF1 AHCY COPS4 SYK ATF3 MED12

9.53e-0611031241534189442
Pubmed

A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve.

APCDD1 CEP192 ASXL3

1.23e-0513124336325906
Pubmed

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.

MED15 MED12 MED13

1.23e-0513124314657022
Pubmed

CDK8 is a positive regulator of transcriptional elongation within the serum response network.

MED15 MED12 MED13

1.23e-0513124320098423
Pubmed

Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms.

PTCH1 GLI2

1.26e-052124225833741
Pubmed

Regulation of LEF-1/TCF transcription factors by Wnt and other signals.

HNF1A TLE1

1.26e-052124210209158
Pubmed

Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology.

MUC16 MUC4

1.26e-052124223544943
Pubmed

Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA.

ZFYVE16 ZFYVE9

1.26e-052124216775010
Pubmed

Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha.

HNF1A MUC4

1.26e-052124217037983
Pubmed

Gastric cancer (GC) patients with hedgehog pathway activation: PTCH1 and GLI2 as independent prognostic factors.

PTCH1 GLI2

1.26e-052124223371028
Pubmed

CREMα suppresses spleen tyrosine kinase expression in normal but not systemic lupus erythematosus T cells.

CREM SYK

1.26e-052124221953500
Pubmed

Hedgehog signaling, keratin 6 induction, and sebaceous gland morphogenesis: implications for pachyonychia congenita and related conditions.

PTCH1 GLI2

1.26e-052124218688029
Pubmed

Structure, function, and activator-induced conformations of the CRSP coactivator.

MED15 MED12 MED13

1.56e-0514124311834832
Pubmed

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

MED15 MED12 MED13

1.95e-0515124318418385
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

DPYSL2 IRS4 DACH1 MPDZ DCTN1 EMSY BRAP MED15 PLEKHA5 MED12

2.89e-055491241038280479
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

FKBP15 SALL4 EMSY MED15 MED12 MED13

3.13e-05167124620362541
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ADAMTS3 ZFYVE16 KDM6B PER2 HERC2

3.68e-0510412459205841
Pubmed

Mutations in UNC80, Encoding Part of the UNC79-UNC80-NALCN Channel Complex, Cause Autosomal-Recessive Severe Infantile Encephalopathy.

UNC79 UNC80

3.77e-053124226708753
Pubmed

Microbial products alter the expression of membrane-associated mucin and antimicrobial peptides in a three-dimensional human endocervical epithelial cell model.

MUC16 MUC4

3.77e-053124223053434
Pubmed

Genetic variants in components of the NALCN-UNC80-UNC79 ion channel complex cause a broad clinical phenotype (NALCN channelopathies).

UNC79 UNC80

3.77e-053124230167850
Pubmed

Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.

MUC16 MUC4

3.77e-053124230236127
Pubmed

Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells.

OTUD4 ATF3

3.77e-053124238553613
Pubmed

ST5 Positively Regulates Osteoclastogenesis via Src/Syk/calcium Signaling Pathways.

DENND2B SYK

3.77e-053124231707778
Pubmed

Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis.

PTCH1 GLI2

3.77e-053124228127049
Pubmed

The role of sonic hedgehog homologue signal pathway in hypospadias aetiology.

PTCH1 GLI2

3.77e-053124234275739
Pubmed

Mediator kinase module and human tumorigenesis.

MED12 MED13

3.77e-053124226182352
Pubmed

Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.

UNC79 UNC80

3.77e-053124221040849
Pubmed

Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling).

MUC16 MUC4

3.77e-053124227483328
Pubmed

MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer.

MUC16 MUC4

3.77e-053124224204560
Pubmed

Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.

UNC79 UNC80

3.77e-053124232620897
Pubmed

Expression of the transmembrane mucins, MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis.

MUC16 MUC4

3.77e-053124224939955
Pubmed

ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage.

ATR POLN

3.77e-053124221242293
Pubmed

Regulation of membrane-associated mucins in the human corneal epithelial cells by dexamethasone.

MUC16 MUC4

3.77e-053124217592322
Pubmed

Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair.

ATR HERC2

3.77e-053124223178497
Pubmed

Nuclear translocation of IGF-1R via p150(Glued) and an importin-β/RanBP2-dependent pathway in cancer cells.

RANBP2 DCTN1

3.77e-053124224909165
Pubmed

Bile-salt-stimulated lipase and mucins from milk of 'secretor' mothers inhibit the binding of Norwalk virus capsids to their carbohydrate ligands.

CEL MUC4

3.77e-053124216266293
Pubmed

Gli1 is important for medulloblastoma formation in Ptc1+/- mice.

PTCH1 GLI2

3.77e-053124215806168
Pubmed

TBX1 and Basal Cell Carcinoma: Expression and Interactions with Gli2 and Dvl2 Signaling.

DVL2 GLI2

3.77e-053124231963474
Pubmed

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

MUC16 MUC4

3.77e-053124235879412
Pubmed

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.

MED15 MED12 MED13

4.11e-0519124316799563
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

HNRNPCL1 RAE1 ATR EIF4A3 HNRNPCL3 OTUD4 TMEM131 PAN3 MED12

4.39e-05462124931138677
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

VAPB RANBP2 IRS4 CAND1 ATP5PO ATR EIF4A3 SMARCAD1 TMEM43 TFG DCTN1 KLHL23 AHCY COPS4 MGAM2 DNPEP

4.89e-0514251241630948266
Pubmed

Human transcription factor protein interaction networks.

HNF1A TSHZ3 IRS4 ATP5PO DACH1 C15orf39 CEP192 RFX7 EMSY MED15 ZFHX4 GLI2 TLE1 OTUD4 HERC2 PAN3

5.05e-0514291241635140242
Pubmed

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.

RANBP2 RAE1 ZFYVE16 BRAP TLE1 AHCY COPS4

5.09e-05267124733417871
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

FKBP15 RANBP2 DPYSL2 HNRNPCL1 ATP5PO MUC16 NEB TFG QSOX1 H2BC1 AHCY DNPEP

5.13e-058441241225963833
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

VAPB RANBP2 DPYSL2 DVL2 CEP192 DCTN1 EMSY ELMO2 TMEM131 MINDY4 HERC2 PAN3

5.68e-058531241228718761
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

RANBP2 DVL2 DACH1 SMARCAD1 DCTN1 CREM EMSY H2BC1 ZFHX4 TLE1 AHCY ATF3

5.93e-058571241225609649
Pubmed

Composite co-activator ARC mediates chromatin-directed transcriptional activation.

MED15 MED12 MED13

7.44e-0523124310235267
Pubmed

HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability.

ATR HERC2

7.53e-054124225326330
Pubmed

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.

MED12 MED13

7.53e-054124219047373
Pubmed

The splicing factor hnRNP C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells.

HNRNPCL1 HNRNPCL3

7.53e-054124223831410
Pubmed

hnRNPC induces isoform shifts in miR-21-5p leading to cancer development.

HNRNPCL1 HNRNPCL3

7.53e-054124235729324
Pubmed

TRPV4 activation in human corneal epithelial cells promotes membrane mucin production.

MUC16 MUC4

7.53e-054124239024979
Pubmed

SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma.

SALL4 PTCH1

7.53e-054124238062245
Pubmed

The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma.

PTCH1 GLI2

7.53e-054124223493353
Pubmed

Hedgehog signaling in neonatal and adult lung.

PTCH1 GLI2

7.53e-054124223371063
Pubmed

N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway.

HNRNPCL1 HNRNPCL3

7.53e-054124236681355
Pubmed

hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability.

HNRNPCL1 HNRNPCL3

7.53e-054124210805751
Pubmed

Hedgehog signaling drives medulloblastoma growth via CDK6.

PTCH1 GLI2

7.53e-054124229202464
Pubmed

The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium.

UNC79 UNC80

7.53e-054124232494638
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

CAND1 ATP5PO RAE1 ATR TMEM43 DCTN1 TMEM131

7.67e-05285124732838362
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

FKBP15 RAE1 C15orf39 TMEM43 NUP58 TFG TBC1D24 TLE1 PLEKHA5 HERC2 DNPEP

8.51e-057541241133060197
Pubmed

An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.

DPYSL2 IRS4 DVL2

9.61e-0525124337589075
Pubmed

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.

RANBP2 RAE1 NUP58

9.61e-0525124310601273
Pubmed

Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.

HNRNPCL1 HNRNPCL3 NEDD9

1.08e-0426124315890332
Pubmed

Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.

RANBP2 RAE1 NUP58

1.08e-0426124312228227
Pubmed

Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.

MED15 MED12 MED13

1.08e-0426124334506481
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

TRAF3IP2 HNRNPCL1 ATR MPDZ C15orf39 SMARCAD1 HNRNPCL3 ELMO2 HNRNPCL4 PLEKHA5

1.17e-046501241038777146
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

RANBP2 ZFYVE16 NEDD9 SYK OTUD4

1.19e-04133124515144186
Pubmed

Autophagic Flux Is Regulated by Interaction Between the C-terminal Domain of PATCHED1 and ATG101.

RB1CC1 PTCH1

1.25e-045124229453315
Pubmed

Evidence for the involvement of the Gli gene family in embryonic mouse lung development.

PTCH1 GLI2

1.25e-04512429268579
Pubmed

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.

PTCH1 GLI2

1.25e-045124230554998
Pubmed

The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation.

PTCH1 GLI2

1.25e-045124219654211
Pubmed

Heterogeneous nuclear ribonucleoprotein C1 may control miR-30d levels in endometrial exosomes affecting early embryo implantation.

HNRNPCL1 HNRNPCL3

1.25e-045124229846695
Pubmed

Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA. Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene.

HNRNPCL1 HNRNPCL3

1.25e-04512429128719
Pubmed

Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism.

HNRNPCL1 HNRNPCL3

1.25e-045124225809670
Pubmed

3D confocal reconstruction of gene expression in mouse.

PTCH1 GLI2

1.25e-045124211118884
Pubmed

The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress.

TBC1D24 NCOA7

1.25e-045124226668325
Pubmed

The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells.

DVL2 GLI2

1.25e-045124227477274
Pubmed

Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6.

TRAF3IP2 SYK

1.25e-045124225202827
Pubmed

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms.

PTCH1 GLI2

1.25e-045124217328886
Pubmed

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

ADAMTS3 PTCH1 KDM6B GLI2 DLEU7

1.32e-04136124525429064
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

VAPB TRAF3IP2 TMEM39B CELF1 GLI2 COPS4 SYK PLEKHA5 MED13

1.36e-04536124915840001
Pubmed

Mediator and cohesin connect gene expression and chromatin architecture.

SALL4 MED15 MED12

1.36e-0428124320720539
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

SGPP2 TMEM39B SALL4 CEP192 PTCH1 DCTN1 CELF1 AOPEP OTUD4 TMEM131 ADAM17 OTULINL PAN3

1.37e-0410841241311544199
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

VAPB TRAF3IP2 TMEM39B CELF1 GLI2 COPS4 SYK PLEKHA5 MED13

1.40e-04538124910512203
Pubmed

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.

VAPB IRS4 EIF4A3 TMEM43 RB1CC1 HERC2

1.55e-04223124634226595
Pubmed

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

VAPB IRS4 CAND1 ATP5PO TMEM43 DCTN1 OTUD4

1.57e-04320124728685749
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

VAPB DPYSL2 IRS4 CAND1 MPDZ NEB COPS4

1.63e-04322124726514267
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

RANBP2 HNRNPCL1 CAND1 RAE1 HNRNPCL3 AHCY

1.66e-04226124637839992
Pubmed

Integrated structural analysis of the human nuclear pore complex scaffold.

RANBP2 RAE1 NUP58

1.67e-0430124324315095
Pubmed

The Structure Inventory of the Nuclear Pore Complex.

RANBP2 RAE1 NUP58

1.67e-0430124327016207
Pubmed

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.

DVL2 PTCH1 GLI2

1.67e-0430124324302887
InteractionHDAC1 interactions

RANBP2 TSHZ3 IKZF2 IRS4 ATR ZFYVE16 DVL2 DACH1 C15orf39 SALL4 SMARCAD1 RB1CC1 DCTN1 CREM EMSY H2BC1 ZFHX4 GLI2 TLE1 SYK PLEKHA5 ATF3 MED12

1.36e-07110812023int:HDAC1
GeneFamilyNucleoporins

RANBP2 RAE1 NUP58

4.06e-04328231051
GeneFamilyCyclins|Mediator complex

MED15 MED12 MED13

4.45e-04338231061
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

TSHZ3 ZFHX4

2.05e-0315822529
GeneFamilyOTU domain containing

OTUD4 OTULINL

2.64e-0317822669
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000

IKZF2 IRS4 CAND1 DHRS3 ADAMTS3 DACH1 SALL4 NUP58 PTCH1 NEDD9 ZFHX4 CELF1 GLI2 OTUD4 PLEKHA5 TNKS2 MED13 CDHR4

5.59e-0780611918gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#2_top-relative-expression-ranked_500

IRS4 ADAMTS3 APCDD1 DACH1 SALL4 ZFHX4

3.15e-06721196gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_500_k2
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SALL4 NEB ZFHX4 TRPM3 ASXL3 UNC79 UNC80

8.58e-0718412472cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SALL4 NEB ZFHX4 TRPM3 ASXL3 UNC79 UNC80

8.58e-071841247ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SALL4 NEB ZFHX4 TRPM3 ASXL3 UNC79 UNC80

8.58e-0718412472b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DHRS3 ARL4D AHCY NCOA7 PLEKHA5 ATF3 MUC4

1.45e-0619912474099df3c052a9536d72ba01492317be7d83a79ad
ToppCellMild/Remission-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NEB MS4A7 CREM ARL4D SYK ARHGAP25

2.28e-0613612461b3c6edcbe0eb674d2d9c838e83ebe2b93e3eec1
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP2 PINLYP CFAP65 MED15 TRPM3 MUC4

4.85e-061551246441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

APCDD1 SMARCAD1 TFG QSOX1 ZC3H10 TMEM131

7.18e-061661246c8fd241088de27c6e741a5dfee3cd770183b6bcb
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP15 NEB MS4A7 SYK ATF3 ADAM17

1.21e-0518212464234d0cc57b5266a5e03133c75c7918abe48465e
ToppCellMild/Remission-B_intermediate-10|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NEB MS4A7 CREM ARL4D SYK ARHGAP25

1.25e-051831246278064c9f0582463b83bf156d34e77f60187613b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 PTCH1 AOPEP GLI2

1.55e-0519012462e592323085ba9c019d678ac2a784462ab470ed9
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RANBP2 HNRNPCL1 EIF4A3 KDM6B MS4A7 CREM

1.55e-0519012464d401b73c0e7eb38e95d0851a128bf12bb0d3a9f
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF2 KDM6B CREM QSOX1 SLC15A1 OTULINL

1.55e-051901246d85b34d19af43d83ebe728f3c7bbefd3792df4a6
ToppCelldroplet-Marrow-nan-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL2 DHRS3 SUSD3 ELMO2 AHCY OTULINL

1.55e-051901246e2fdbfaf08da3274b6bdda615386aa880040a90a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 PTCH1 AOPEP GLI2

1.55e-051901246445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 PTCH1 AOPEP GLI2

1.59e-051911246c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 PTCH1 AOPEP GLI2

1.59e-051911246cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TSHZ3 DACH1 PTCH1 HOXB3 ZFHX4 GLI2

1.74e-051941246b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TSHZ3 DACH1 PTCH1 HOXB3 ZFHX4 GLI2

1.79e-0519512460e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KDM6B MS4A7 CREM ARHGAP25 ATF3 ADAM17

1.79e-051951246fa8ac154e5aebc26463ff84f0ad1038095770bc6
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 APCDD1 PTCH1 DENND2B ZFHX4 GLI2

1.90e-051971246ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 APCDD1 PTCH1 DENND2B ZFHX4 GLI2

1.90e-05197124637f6b6f2809b952382eaebb642b0aad6371f4251
ToppCell3'-Adult-SmallIntestine|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SUSD3 SLC13A2 OTC SLC15A1 FAM151A ARHGAP25

1.90e-0519712461614bc5f41fd2c8385e58ed6b87ef1536421f29a
ToppCellILEUM-inflamed-(8)_Fibroblasts|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

APCDD1 DACH1 PTCH1 DENND2B QSOX1 KLHL23

2.01e-0519912463a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Car3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IRS4 ADAMTS3 FAM151A LIPM CHST4

3.68e-0513412454ef5f395e321cf04e56560be2502a8aa157682f4
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_2|367C / Donor, Lineage, Cell class and subclass (all cells)

MUC16 KDM6B MS4A7 NEDD9 ATF3

4.70e-051411245e409da87da5a38ba4d0ccc5e3f8bd89f480f9dab
ToppCellfacs-Thymus-Flowthrough-24m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEL DHRS3 SLC13A2 FAM151A KLHL23

8.06e-051581245c870fd17213129943562487338e2669e2930d719
ToppCellControl-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NEB MS4A7 ARL4D SYK ARHGAP25

9.07e-051621245aa80452b972bb8ad3670ffaba4ce26fadb33b185
ToppCellCOVID-19-lung-Mesothelial|COVID-19 / Disease (COVID-19 only), tissue and cell type

DLGAP2 ADAMTS3 MUC16 ZFHX4 GLI2

9.61e-05164124583303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCellfacs-Heart-RA-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E SGPP2 SUSD3 LIPM SYK

9.89e-05165124536415924d05373e9dd3665be599f4f3f40bf0497
ToppCellfacs-Heart-RA-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E SGPP2 SUSD3 LIPM SYK

9.89e-05165124556310fddd3d8e4afdfde066d26cee9747e5b8c6a
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-Lymphoid_DC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1E DLGAP2 MUC16 ZC3H10 ZNF85

1.05e-0416712458b223333c0c7a85b5a1af6f2f5b12ee0d94357f6
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFYVE16 MS4A7 ZFHX4 GLI2 OTULINL

1.05e-041671245f5bffa77061baec0ba87bd688a047595f32534db
ToppCelldroplet-Heart-4Chambers-21m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SUSD3 MPDZ PER2 TRPM3 OPLAH

1.17e-041711245e852d0e8589eecf4a2e5fea039b52a67c5d58dbd
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1E QSOX1 TLE1 OTULINL MMD

1.27e-041741245c529f3674b784f872f4387ffdeb46aecb619976b
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SUSD3 MUC16 SYNPR FAM151A CHST4

1.41e-0417812451e05bc26591fea16e29bcfc5f538dda1dc427f05
ToppCellmetastatic_Brain-T/NK_cells-Exhausted_Tfh|T/NK_cells / Location, Cell class and cell subclass

RANBP2 DCTN1 UBXN11 CELF1 SLC49A3

1.41e-0417812459a3581a0158dfa5a1cc942f8c532afb5e38b272a
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IKZF2 MUC16 SALL4 PER2 MUC4

1.45e-0417912456e965e424eebef50f0202cff75f458be395cfca1
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SUSD3 NEB SYK ARHGAP25 OTULINL

1.45e-04179124530efe1f0394c0edb27b91890b5c4637b73cbc5ec
ToppCellCOVID-19-kidney-CD-IC-B|COVID-19 / Disease (COVID-19 only), tissue and cell type

SGPP2 DACH1 HMX2 HOXB3 NCOA7

1.56e-041821245ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell3'-Adult-SmallIntestine-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC13A2 OTC SLC15A1 FAM151A MGAM2

1.65e-041841245ed7a8e79e5723a5f5a03f542203d9e50bdef5f50
ToppCellMild/Remission-B_intermediate-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

DPYSL2 MS4A7 ARL4D SYK ARHGAP25

1.65e-0418412453d4864605c812862cf8926e02370eea3b8ccf32f
ToppCellFrontal_cortex-Neuronal-Excitatory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CACNA1E CFAP65 CELF1 MMD GABRA5

1.65e-0418412456e17c8151d6dc543de16d804db956c63c3fda414
ToppCellControl-Epithelial_cells-Airway_goblet|Control / group, cell type (main and fine annotations)

MUC16 SLC15A1 DLEU7 MUC4 MGAM2

1.65e-041841245d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL2 QSOX1 SLC15A1 CHST4 PAN3

1.69e-041851245fd1911b57927c03470f9387962ca9581e5643fb3
ToppCellfacs-Large_Intestine-Distal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL2 QSOX1 SLC15A1 CHST4 PAN3

1.69e-0418512457a18d525de6f874924bfc61b9666b307da86421a
ToppCell3'-Adult-SmallIntestine-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC13A2 OTC SLC15A1 FAM151A MGAM2

1.73e-041861245bdd9d3a432aab46e733469b362f0064d35c1ac49
ToppCell(5)_Glands_duct|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

MUC16 SLC13A2 MS4A7 NEDD9 CHST4

1.73e-041861245ad8d5010e5095508f4995e0c6c016a44e8ffb8dd
ToppCellE16.5-samps-Mesenchymal-Myofibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

TSHZ3 PTCH1 HOXB3 OTC AOPEP

1.73e-041861245e044b3428b7eacfdc72d0f57cdabaa1de04c74cd
ToppCell3'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC13A2 OTC SLC15A1 FAM151A MGAM2

1.77e-0418712459042bd0f57213a51503d9df2e4dce3209b7772d3
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

RANBP2 IKZF2 NEB CREM TLE1

1.77e-041871245f31d865ce2a21bdf64dbe29ee3e4505ab482604a
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DACH1 PTCH1 TLE1 DLEU7 OTULINL

1.86e-041891245b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS3 RAB11FIP2 DACH1 SYNPR HOXB3

1.86e-04189124590aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial-large_intestine_goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL2 MS4A7 QSOX1 CHST4 UNC79

1.86e-041891245e11998c57609c5714705713ac3a32016d6d841dd
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 PTCH1 GLI2

1.86e-041891245c734e5693808a0333139e87bd5be2597a9252afe
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS3 RAB11FIP2 DACH1 HOXB3 ASXL3

1.91e-0419012454836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCellControl-Epithelial-Ciliated_cells|Control / Condition, Lineage and Cell class

MUC16 CFAP65 CFAP57 MUC4 CDHR4

1.96e-041911245ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 PTCH1 GLI2

1.96e-041911245806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 CFAP65 CFAP57 MUC4 CDHR4

1.96e-041911245e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 CFAP65 CFAP57 MUC4 CDHR4

1.96e-0419112459d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellwk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

MUC16 CFAP65 CFAP57 MUC4 CDHR4

1.96e-041911245e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCellControl-Epithelial|Control / Condition, Lineage and Cell class

MUC16 CFAP65 CFAP57 MUC4 CDHR4

1.96e-0419112456228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 CFAP65 CFAP57 MUC4 CDHR4

1.96e-0419112451c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 DENND2B GLI2

2.01e-0419212459093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellCOVID-19-kidney-CNT|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS3 SGPP2 DACH1 HOXB3 TRPM3

2.01e-041921245760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SALL4 PTCH1 HOXB3 ZFHX4 GLI2

2.01e-04192124567e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 DENND2B GLI2

2.01e-0419212459ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellPBMC-Severe-cDC_0|Severe / Compartment, Disease Groups and Clusters

QSOX1 UBXN11 ZFYVE9 OTUD4 ADAM17

2.01e-0419212454f4774b925058191673b4ba4b4d05b8b37f61795
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DACH1 PTCH1 HOXB3 TLE1 UNC80

2.01e-04192124572881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCellCOVID-19-kidney-CNT|kidney / Disease (COVID-19 only), tissue and cell type

ADAMTS3 RAB11FIP2 DACH1 DENND2B HOXB3

2.01e-041921245d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCellControl-B_intermediate-10|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NEB MS4A7 CREM ARL4D SYK

2.01e-041921245224bd958369ba8fa0d7be2126f7dc61c9f6ac19d
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

DACH1 TRPM3 AOPEP PLEKHA5 PAN3

2.01e-041921245e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

RANBP2 CAND1 ATR ZFYVE16 MED13

2.05e-041931245abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL2 CREM QSOX1 CHST4 MUC4

2.05e-0419312454aee372ba2c0351b0221d0d468707d1ad21526d6
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DENND2B CFAP65 PLEKHA5 CFAP57 CDHR4

2.05e-041931245ea345d34440b25f65358a53dc72831998d1c3620
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ATR ADAMTS3 SGPP2 C15orf39 NCOA7

2.05e-0419312450ef076417ffe2dd1cbc2c3d1e35c7f8522af143b
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARL4D PER2 NCOA7 PLEKHA5 ATF3

2.05e-041931245739fb2a57772a800a2e94bdd6c71285bb2c162a7
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-secretory_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL2 CREM QSOX1 CHST4 MUC4

2.05e-041931245aaa5042388dc451bff384c6bb237348f08280a08
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MUC16 CFAP65 CFAP57 MUC4 CDHR4

2.10e-041941245756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCellPBMC-Severe-cDC_5|Severe / Compartment, Disease Groups and Clusters

RANBP2 ATP5PO KDM6B CREM ATF3

2.10e-041941245b903e23eb75733ca516770727097fe74a9f8c1d1
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DACH1 SUSD3 PTCH1 AOPEP DLEU7

2.10e-041941245735eee6ef25589f935fa922788ebbdbfef61249e
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

APCDD1 DACH1 PTCH1 HOXB3 TLE1

2.10e-041941245fb80a0271ccb1cb3f954ebcf2c5945cb6adb6b8c
ToppCell368C-Myeloid-Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ZFYVE16 EIF4A3 KDM6B CREM ATF3

2.10e-041941245f9b9cbd1a418a7cbd151c2425fda6b864db9aa82
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DHRS3 DACH1 SALL4 DENND2B GLI2

2.10e-04194124590efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DHRS3 DACH1 SALL4 DENND2B GLI2

2.10e-041941245df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CEL MUC16 ASXL3 UNC79 UNC80

2.10e-0419412452dcc3b99dbedaf8a6916891c85091ddb79d7ee31
ToppCellCOVID-19-Epithelial-Ciliated_cells|COVID-19 / Condition, Lineage and Cell class

MUC16 CFAP65 CFAP57 MUC4 CDHR4

2.10e-04194124543be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TSHZ3 DACH1 SALL4 PTCH1 HOXB3

2.15e-041951245c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 PTCH1 GLI2

2.15e-041951245d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell343B-Myeloid-Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ZFYVE16 EIF4A3 KDM6B CREM ATF3

2.15e-041951245ff87a33f9a48765bfa9408f686985feefeff2adf
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KDM6B MS4A7 CREM ARHGAP25 ATF3

2.15e-041951245562e4c0e4e81f6303e57b846da71d1667fc35963
ToppCell368C-Myeloid-Monocyte-CD14+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ZFYVE16 EIF4A3 KDM6B CREM ATF3

2.15e-0419512458da933942e9033e18e25ab47831c269747b1c0b2
ToppCellPBMC-Control-cDC_7|Control / Compartment, Disease Groups and Clusters

ATP5PO KDM6B CREM ATF3 ZNF85

2.15e-041951245c8f9f2911c2f963b5d1336fbb5567bfc7f3e737b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 PTCH1 GLI2

2.21e-041961245a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCelltumor_Lymph_Node_/_Brain|World / Location, Cell class and cell subclass

APCDD1 MUC16 AOPEP ATF3 MUC4

2.21e-041961245b39f938cbef54f08c53035738b97c76e7295733a
ToppCellkidney_cells-Adult_normal_reference|kidney_cells / Celltypes from Cells and Nuclei per compartment and clinical group

DHRS3 CREM NEDD9 FAM151A ATF3

2.21e-041961245902965bfc5726ca0f1f0a1f6fe3f6d701cc91e6b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 DHRS3 DACH1 PTCH1 GLI2

2.21e-0419612453e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-myocytic|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

APCDD1 PTCH1 DENND2B ARL4D AOPEP

2.21e-04196124520dc9b25ecc23b6e6e52bbab8b5a404f3245ca37
ToppCellMild/Remission-B_intermediate-6|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

DPYSL2 MS4A7 ARL4D SYK ARHGAP25

2.26e-0419712455370dda4a25e3a53d6fe2c887b7dabd7a58462b4
ToppCell10x3'2.3-week_17-19|World / cell types per 3 fetal stages;per 3',per 5'

EIF4A3 KDM6B ARL4D ATF3 ADAM17

2.26e-041971245f5cfad0b42d0f817e22cc78b9bfb2b4b7e4330ed
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

EIF4A3 KDM6B CREM ARL4D ATF3

2.26e-041971245cd54e6ad175529327fa0372033016b3b978dd452
Diseaseage at menarche

DLGAP2 SMARCAD1 RB1CC1 ZFHX4 CELF1 TRPM3 PAN3 UNC79 MMD UNC80

1.41e-0459411810EFO_0004703
DiseaseBasal Cell Nevus Syndrome

PTCH1 GLI2

1.57e-0451182C0004779
DiseaseAutistic behavior

TRPM3 MED13

4.37e-0481182C0856975
Diseaselevel of Sterol ester (27:1/16:1) in blood serum

HNF1A ATF3

5.60e-0491182OBA_2045190
Diseasehair colour measurement, eye colour measurement, skin pigmentation measurement

RAB11FIP2 HERC2

6.99e-04101182EFO_0007009, EFO_0007822, EFO_0009764
DiseaseHoloprosencephaly sequence

PTCH1 GLI2

6.99e-04101182cv:C0079541
Diseasepancreatic cancer (is_marker_for)

EIF4A3 MUC16 PTCH1 MUC4

7.36e-041011184DOID:1793 (is_marker_for)
Diseaseatopic dermatitis (implicated_via_orthology)

TRAF3IP2 ADAM17

8.52e-04111182DOID:3310 (implicated_via_orthology)
Diseasemotor neuron disease (implicated_via_orthology)

VAPB DCTN1

1.02e-03121182DOID:231 (implicated_via_orthology)
Diseasesusceptibility to rubella infection measurement

OTC TRPM3 AOPEP

1.19e-03521183EFO_0008418
DiseaseMaturity onset diabetes mellitus in young

HNF1A CEL

1.40e-03141182C0342276
Diseaseserum metabolite measurement

CACNA1E HNF1A DPYSL2 RAE1 RAB11FIP2 SGPP2 NUP58 CELF1 OTUD4 NCOA7 OPLAH

1.46e-0394511811EFO_0005653
DiseaseAlobar Holoprosencephaly

PTCH1 GLI2

1.61e-03151182C0431363
Diseasehepcidin:transferrin saturation ratio

MUC16 PAN3

1.61e-03151182EFO_0007902
DiseaseLobar Holoprosencephaly

PTCH1 GLI2

1.83e-03161182C0431362
DiseaseSemilobar Holoprosencephaly

PTCH1 GLI2

1.83e-03161182C0751617
DiseaseHoloprosencephaly

PTCH1 GLI2

2.07e-03171182C0079541
DiseaseAmyotrophic lateral sclerosis

VAPB DCTN1

2.07e-03171182cv:C0002736
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

RFX7 MED13

2.07e-03171182DOID:0060307 (is_implicated_in)
Diseasesynophrys measurement

PTCH1 ZFHX4 HERC2

2.59e-03681183EFO_0007906
Diseaselevel of Sphingomyelin (d38:2) in blood serum

HNF1A ADAMTS3

2.59e-03191182OBA_2045179
Diseaseneurodegenerative disease (implicated_via_orthology)

VAPB DVL2 PTCH1 TBC1D24

2.78e-031451184DOID:1289 (implicated_via_orthology)
Diseaseasthma, age at onset

EMSY BRAP OTULINL

2.81e-03701183EFO_0004847, MONDO_0004979
Diseasered blood cell density measurement

HNF1A DHRS3 ATR RAB11FIP2 KDM6B RFX7 DENND2B TRPM3 OTUD4 MUC4

2.85e-0388011810EFO_0007978
Diseasemyocardial infarction

HNF1A CEL EIF4A3 DENND2B BRAP SLC15A1

2.89e-033501186EFO_0000612
DiseaseCleft palate

DACH1 PTCH1 SLC15A1

2.92e-03711183HP_0000175
DiseaseHIV-1 infection, Susceptibility to viral and mycobacterial infections

NEDD9 ADAM17

3.17e-03211182EFO_0000180, Orphanet_391311
Diseasereticulocyte measurement

ATR EIF4A3 KDM6B DENND2B BRAP CELF1 DLEU7 NCOA7 TMEM131 ARHGAP25 MED12

3.36e-03105311811EFO_0010700
DiseaseMental Depression

DPYSL2 PER2 TLE1 ATF3 MED12

3.61e-032541185C0011570

Protein segments in the cluster

PeptideGeneStartEntry
PSNKCMAIHSPVMSS

SYNPR

161

Q8TBG9
MAIHSPVMSSLNTSV

SYNPR

166

Q8TBG9
AMTSHDLMKFVAPFN

BRAP

171

Q7Z569
TQIHPLMSQMSGSVT

CDY1

201

Q9Y6F8
MGNHLTEMAPTASSF

ARL4D

1

P49703
MAALHYPSTTALQEM

NEDD9

796

Q14511
AMVPHSSMFIFSTTN

CACNA1E

1126

Q15878
ANRHMSLLTAFMPDS

DCTN1

581

Q14203
AIPKSFMISADMAHA

DNPEP

346

Q9ULA0
KAMHQAQTMEGCSSP

CELF1

166

Q92879
MMPVVLGDHVSSSTF

DLGAP2

146

Q9P1A6
LGMASPHIMFLSQSI

AOPEP

451

Q8N6M6
TNNMDGHIFASIDMP

CEL

336

P19835
MTMTANKNSSITHGA

DENND2B

1

P78524
PPASVTMAMSQMNHL

DACH1

446

Q9UI36
MSQAPSSVMSLHFDG

CDHR4

751

A6H8M9
PPELTASRQSFHMAM

DVL2

711

O14641
ASRQSFHMAMGNPSE

DVL2

716

O14641
SLVAHPTVAMFTGNM

ASXL3

1406

Q9C0F0
SAFSTMMSVHRGEVP

ATP5PO

126

P48047
PLSSVAQKIMSAMHS

POLN

16

Q7Z5Q5
SMFGSATTDNHNPMK

RAE1

16

P78406
MHTPPVQSSSACMFS

RANBP2

921

P49792
AHFPMQTEASVNGQM

OTUD4

766

Q01804
FEQMAAASMHRVGSP

QSOX1

456

O00391
LMMPAVFHTVASRTQ

RB1CC1

106

Q8TDY2
HTSKATSPMGITFAM

MUC16

5741

Q8WXI7
TISQGFSHSQMSTLM

MUC16

7936

Q8WXI7
MMTSTLFSSPSVHNV

MUC4

96

Q99102
TNKMDPHSMNSRVFI

HNRNPCL1

6

O60812
MMSFAPNASHSPVFL

OR1B1

1

Q8NGR6
MGIMAFAHQPTFSRI

LIM2

81

P55344
PAMNTHSSRQNFMGL

MGAM2

1676

Q2M2H8
MASPAPLVASISHQM

DLEU7

1

Q6UYE1
MFQRNVNSVHMPTKA

LIPM

26

Q5VYY2
DVHTRFQMPDQGMTS

DPYSL2

71

Q16555
NIHPTAMMFTSTINL

HERC2

1956

O95714
MASSGMADSANHLPF

SYK

1

P43405
TNKMDPHSMNSRVFI

HNRNPCL3

6

B7ZW38
PSYEQMVAASSHSQM

CFAP57

266

Q96MR6
SHSQMSMPQVFAIAA

CFAP57

276

Q96MR6
ISAQPASSMDTQMHS

CFAP65

116

Q6ZU64
NFTVSSMHGDMPQKE

EIF4A3

301

P38919
PAFMRVTSTGNMLSH

KDM6B

1351

O15054
TAMGSFSSHMTEFPR

ARNTL2

36

Q8WYA1
MHVSQMAISFLTTLA

CAND1

706

Q86VP6
MLLQSQTMGVSHSFT

MS4A7

1

Q9GZW8
QSPDTFSLMMAKSEH

PER2

76

O15055
FSLMMAKSEHNPSTS

PER2

81

O15055
SSSHSMDTDKMAPVF

OR5B3

261

Q8NH48
MSAAKFGMHLQAATP

OTC

206

P00480
FAAMLMPHQKATTAD

COPS4

281

Q9BT78
QKHSAGNSMLIPSMS

FKBP15

541

Q5T1M5
NMAHASAQTLVSMPL

HMX2

216

A2RU54
MAPHSMAVVSTATPQ

MED15

136

Q96RN5
STTMGPKDHMVTSSF

PINLYP

86

A6NC86
QSHVTQSPFMATMAQ

HNF1A

481

P20823
FSHQTLQQTPMISTM

MED12

2016

Q93074
SMNLSSHFGFSQMPT

GABRA5

21

P31644
ARATGHAMAAMPSSQ

GLI2

1396

P10070
TNKMDPHSMNSRVFI

HNRNPCL4

6

P0DMR1
PTSATGNHMTMSVLR

PRSS54

171

Q6PEW0
PSHMTSTNSVKLEMQ

IKZF2

41

Q9UKS7
MGFSPALVVTSMNNT

MMD

161

Q15546
TSSDPLSFMMNHLNS

OTULINL

276

Q9NUU6
MSAFSQVFSHPSMGS

PAN3

311

Q58A45
HPDTGISSKAMSIMN

H2BC1

51

Q96A08
MKSSPLMFVNVSGSH

ATR

76

Q13535
MGSVMAPLVQAAFHR

ADAMTS3

421

O15072
NPMHKEISQRSTATM

KLHL23

261

Q8NBE8
MLGFTNHINPAMDFT

ELMO2

351

Q96JJ3
QPVSFQMQAMLLGHS

FAM151A

506

Q8WW52
STAGFMNALHSMTPS

HOXB3

271

P14651
VNHMKVTPMDAATAS

APCDD1

366

Q8J025
MMLQHPGQVSASEVS

ATF3

1

P18847
LALFPHMATTAFMQP

HEPHL1

676

Q6MZM0
STVHSSVADMQNMPA

CEP192

1231

Q8TEP8
SLPSTHMVVAGMANS

EMSY

1186

Q7Z589
FHMQSESLIGPLMQT

DNAAF5

201

Q86Y56
SHMAAATGDMPTYQI

CREM

241

Q03060
NTATSAMMVPIAHAV

SLC13A2

141

Q13183
MGHPSFVMSNSFTNQ

AHCY

351

P23526
VTLGPMSQTNAFMTF

SLC15A1

416

P46059
HSASPTLGFAMMASL

SALL4

716

Q9UJQ4
TVLPFHTSTEMFQGM

DHRS3

216

O75911
STMPNAAAVAMAATL

NUP58

456

Q9BVL2
FNSAMTPAMALADSA

IRS4

1021

O14654
MAGRMSTSNHTQFHP

OR52E8

1

Q6IFG1
SSKTMHLMGDFSAPA

SYPL2

101

Q5VXT5
GSSSSPQAQVMVHMA

SUSD3

216

Q96L08
GHKNPSAMAVESFMA

TMEM43

166

Q9BTV4
LNFVMPHMFSSSTSE

SMARCAD1

671

Q9H4L7
PMRKSFATHTAAMVQ

NCOA7

666

Q8NI08
LGFTHVSLSSEAMPM

OPLAH

211

O14841
SAHALQTMFQLMTPK

PTCH1

356

Q13635
HPTAMMFTSTINLLQ

HERC2P3

686

Q9BVR0
VAKTPQMHGTEMANS

MED13

516

Q9UHV7
GMPSTHAMAATAIAF

SGPP2

161

Q8IWX5
LMMNDLLPATSTSSH

HTR3D

276

Q70Z44
SLFHPSNVEMLSSMD

ADAM17

706

P78536
HAMAKSPDFMNSFRI

CIB4

166

A0PJX0
MAPNSLSAPTMLHNS

TRAF3IP2

51

O43734
MYSHNISSLSMKAQP

CHST4

26

Q8NCG5
DAMPRTNFHSSVAFM

C15orf39

636

Q6ZRI6
PEHQRATANMLATMS

SLC49A3

156

Q6UXD7
RHFNLPSKTESMFMA

TBC1D24

486

Q9ULP9
YASLHNMSPQMSAAA

TLE1

391

Q04724
LTVQQPGMMDSSSLH

ZFHX4

3031

Q86UP3
SHVSSMSVPQAEVGM

UNC80

3001

Q8N2C7
MMAAVKSTEAHPSSN

ZSCAN32

1

Q9NX65
FIAMMHPTGVAAQTQ

MPDZ

1891

O75970
MMSGPIASSPQDSFH

MINDY4

211

Q4G0A6
QSTQVMAASMSAFDP

TFG

156

Q92734
SNPMSKLTVLNSMHS

TRPM3

276

Q9HCF6
VMTGEQMAAFHPSST

ARHGAP25

26

P42331
FTLLFMPSTSSMHID

TMEM131

501

Q92545
VLSARNSMMFGHLSP

nan

31

A8MX80
PASHMSSLNVVKMTT

RFX7

366

Q2KHR2
KFRASNIMPSSSFHM

RAB11FIP2

411

Q7L804
SFLQFSAMKMAHSPP

TNKS2

1106

Q9H2K2
SSQTSPMPKTNFHAM

TSHZ3

596

Q63HK5
MVAKPTVMCSHFAQD

ZNF85

71

Q03923
HKFMVQSMFAPTDTS

VAPB

86

O95292
MAQPLAGITMSHTTT

ZC3H10

401

Q96K80
SPKTMVNISDQTMHS

PLEKHA5

526

Q9HAU0
LSARNSMMFGHLSPV

nan

31

A6NL46
SPNSFSHMSEGILMK

ZFYVE9

306

O95405
ERMMSPTGSNLKSNH

ZFYVE16

811

Q7Z3T8
LRKTSLFNHMASMGP

TMEM39B

211

Q9GZU3
LFNHMASMGPREAVS

TMEM39B

216

Q9GZU3
QVPASHDSELMAFMT

UBXN11

66

Q5T124
PAHVNLSASSMLMIA

UNC79

216

Q9P2D8
FTSVPDSMGMVLAQH

NEB

1481

P20929