Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	translation elongation factor binding	SERBP1 HABP4	3.16e-07	3	7	2	GO:0061770
GeneOntologyMolecularFunction	SUMO binding	SERBP1 HABP4	1.80e-05	19	7	2	GO:0032183
GeneOntologyMolecularFunction	ribosome binding	SERBP1 HABP4	7.37e-04	120	7	2	GO:0043022
GeneOntologyMolecularFunction	ubiquitin-like protein binding	SERBP1 HABP4	8.38e-04	128	7	2	GO:0032182
GeneOntologyMolecularFunction	mRNA binding	CHTOP SERBP1 FUS	1.32e-03	694	7	3	GO:0003729
GeneOntologyMolecularFunction	ribonucleoprotein complex binding	SERBP1 HABP4	2.15e-03	206	7	2	GO:0043021
GeneOntologyMolecularFunction	mRNA 3'-UTR binding	SERBP1 FUS	3.82e-03	276	7	2	GO:0003730
GeneOntologyMolecularFunction	transcription coregulator activity	EWSR1 FUS	1.51e-02	562	7	2	GO:0003712
GeneOntologyMolecularFunction	chromatin binding	FUS ZC3H4	2.54e-02	739	7	2	GO:0003682
GeneOntologyBiologicalProcess	ribosome hibernation	SERBP1 HABP4	2.96e-07	3	7	2	GO:0141014
GeneOntologyBiologicalProcess	PML body organization	SERBP1 HABP4	3.55e-06	9	7	2	GO:0030578
GeneOntologyBiologicalProcess	RNA catabolic process	SERBP1 FUS ZC3H4 LSM4	6.32e-06	432	7	4	GO:0006401
GeneOntologyBiologicalProcess	nucleic acid catabolic process	SERBP1 FUS ZC3H4 LSM4	8.39e-06	464	7	4	GO:0141188
GeneOntologyBiologicalProcess	nuclear body organization	SERBP1 HABP4	2.27e-05	22	7	2	GO:0030575
GeneOntologyBiologicalProcess	nucleobase-containing compound catabolic process	SERBP1 FUS ZC3H4 LSM4	4.15e-05	696	7	4	GO:0034655
GeneOntologyBiologicalProcess	mRNA metabolic process	SERBP1 FUS LSM4 HABP4	1.22e-04	917	7	4	GO:0016071
GeneOntologyBiologicalProcess	mRNA catabolic process	SERBP1 FUS LSM4	1.95e-04	373	7	3	GO:0006402
GeneOntologyBiologicalProcess	RNA splicing	FUS LSM4 HABP4	4.66e-04	502	7	3	GO:0008380
GeneOntologyBiologicalProcess	nucleus organization	SERBP1 HABP4	1.38e-03	170	7	2	GO:0006997
GeneOntologyBiologicalProcess	regulation of RNA splicing	FUS HABP4	2.04e-03	207	7	2	GO:0043484
GeneOntologyBiologicalProcess	negative regulation of translation	SERBP1 HABP4	2.51e-03	230	7	2	GO:0017148
GeneOntologyBiologicalProcess	regulation of mRNA stability	SERBP1 FUS	4.00e-03	292	7	2	GO:0043488
GeneOntologyBiologicalProcess	regulation of RNA stability	SERBP1 FUS	4.44e-03	308	7	2	GO:0043487
GeneOntologyBiologicalProcess	regulation of mRNA catabolic process	SERBP1 FUS	4.47e-03	309	7	2	GO:0061013
GeneOntologyBiologicalProcess	post-transcriptional regulation of gene expression	SERBP1 FUS HABP4	5.14e-03	1153	7	3	GO:0010608
GeneOntologyBiologicalProcess	regulation of mRNA metabolic process	SERBP1 FUS	9.00e-03	443	7	2	GO:1903311
GeneOntologyBiologicalProcess	RNA processing	FUS LSM4 HABP4	1.08e-02	1500	7	3	GO:0006396
GeneOntologyBiologicalProcess	regulation of translation	SERBP1 HABP4	1.11e-02	494	7	2	GO:0006417
GeneOntologyCellularComponent	Cajal body	EWSR1 HABP4	3.31e-04	84	7	2	GO:0015030
GeneOntologyCellularComponent	nuclear body	CHTOP EWSR1 HABP4	2.47e-03	903	7	3	GO:0016604
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	LSM4 HABP4	3.32e-03	269	7	2	GO:0036464
GeneOntologyCellularComponent	ribonucleoprotein granule	LSM4 HABP4	3.77e-03	287	7	2	GO:0035770
GeneOntologyCellularComponent	nuclear speck	CHTOP HABP4	8.32e-03	431	7	2	GO:0016607
MousePheno	increased mortality induced by gamma-irradiation	EWSR1 FUS	1.02e-04	37	6	2	MP:0001658
MousePheno	increased mortality induced by ionizing radiation	EWSR1 FUS	1.94e-04	51	6	2	MP:0003992
MousePheno	abnormal mortality induced by ionizing radiation	EWSR1 FUS	2.26e-04	55	6	2	MP:0020149
MousePheno	abnormal response to radiation	EWSR1 FUS	2.42e-04	57	6	2	MP:0012734
MousePheno	spleen hypoplasia	CHTOP EWSR1	1.22e-03	128	6	2	MP:0000694
MousePheno	abnormal hypodermis morphology	CHTOP EWSR1	2.42e-03	181	6	2	MP:0003705
MousePheno	abnormal cell nucleus morphology	EWSR1 FUS	2.50e-03	184	6	2	MP:0003111
MousePheno	abnormal male meiosis	EWSR1 FUS	2.80e-03	195	6	2	MP:0005169
MousePheno	open neural tube	CHTOP ZC3H4	3.74e-03	226	6	2	MP:0000929
MousePheno	abnormal meiosis	EWSR1 FUS	4.24e-03	241	6	2	MP:0001930
MousePheno	abnormal female reproductive system physiology	EWSR1 FUS ZC3H4	4.25e-03	876	6	3	MP:0003699
Domain	IHABP4_N	SERBP1 HABP4	1.20e-07	2	7	2	PF16174
Domain	HABP4_PAI-RBP1	SERBP1 HABP4	1.20e-07	2	7	2	SM01233
Domain	IHABP4_N	SERBP1 HABP4	1.20e-07	2	7	2	IPR032381
Domain	-	EWSR1 FUS	5.41e-06	10	7	2	4.10.1060.10
Domain	HABP4_PAIRBP1-bd	SERBP1 HABP4	1.44e-05	16	7	2	IPR006861
Domain	HABP4_PAI-RBP1	SERBP1 HABP4	1.44e-05	16	7	2	PF04774
Domain	zf-RanBP	EWSR1 FUS	2.77e-05	22	7	2	PF00641
Domain	ZnF_RBZ	EWSR1 FUS	3.03e-05	23	7	2	SM00547
Domain	ZF_RANBP2_2	EWSR1 FUS	3.03e-05	23	7	2	PS50199
Domain	ZF_RANBP2_1	EWSR1 FUS	3.31e-05	24	7	2	PS01358
Domain	Znf_RanBP2	EWSR1 FUS	3.60e-05	25	7	2	IPR001876
Domain	RRM_1	EWSR1 FUS	2.50e-03	208	7	2	PF00076
Domain	RRM	EWSR1 FUS	2.72e-03	217	7	2	SM00360
Domain	RRM_dom	EWSR1 FUS	2.97e-03	227	7	2	IPR000504
Domain	RRM	EWSR1 FUS	3.04e-03	230	7	2	PS50102
Domain	-	EWSR1 FUS	3.42e-03	244	7	2	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	EWSR1 FUS	3.81e-03	258	7	2	IPR012677
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	CHTOP FUS LSM4	1.44e-04	277	6	3	MM15414
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	CHTOP FUS LSM4	1.53e-04	283	6	3	M13087
Pathway	WP_MRNA_PROCESSING	EWSR1 FUS LSM4	6.05e-04	451	6	3	MM15946
Pathway	REACTOME_METABOLISM_OF_RNA	CHTOP FUS LSM4	1.48e-03	612	6	3	MM15547
Pathway	REACTOME_METABOLISM_OF_RNA	CHTOP FUS LSM4	2.40e-03	724	6	3	M16843
Pathway	REACTOME_MRNA_SPLICING	FUS LSM4	2.92e-03	201	6	2	MM15411
Pathway	REACTOME_MRNA_SPLICING	FUS LSM4	3.24e-03	212	6	2	M14033
Pubmed	TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.	EWSR1 SERBP1 FUS	5.99e-10	10	7	3	18632687
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CHTOP EWSR1 SERBP1 FUS ZC3H4 LSM4	1.05e-09	807	7	6	22681889
Pubmed	Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation.	EWSR1 SERBP1 HABP4	2.27e-09	15	7	3	16879614
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	EWSR1 SERBP1 FUS ZC3H4 LSM4	3.99e-09	399	7	5	35987950
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	CHTOP EWSR1 SERBP1 FUS ZC3H4	2.01e-08	551	7	5	34728620
Pubmed	A morphologic and molecular reappraisal of myoepithelial tumors of soft tissue, bone, and viscera with EWSR1 and FUS gene rearrangements.	EWSR1 FUS	3.47e-08	2	7	2	31994243
Pubmed	Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.	EWSR1 FUS	3.47e-08	2	7	2	8921363
Pubmed	EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.	EWSR1 FUS	3.47e-08	2	7	2	26573619
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	CHTOP EWSR1 SERBP1 FUS ZC3H4	4.75e-08	655	7	5	35819319
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	CHTOP EWSR1 SERBP1 FUS	7.12e-08	236	7	4	36339263
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	CHTOP EWSR1 SERBP1 FUS LSM4	7.15e-08	711	7	5	33022573
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	CHTOP SERBP1 FUS ZC3H4 LSM4	7.25e-08	713	7	5	29802200
Pubmed	ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center.	EWSR1 SERBP1 FUS	7.55e-08	46	7	3	20890123
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	CHTOP EWSR1 FUS ZC3H4 LSM4	8.21e-08	731	7	5	29298432
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	EWSR1 SERBP1 FUS HABP4	1.02e-07	258	7	4	37794589
Pubmed	The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome.	EWSR1 SERBP1 FUS	1.04e-07	51	7	3	26269332
Pubmed	Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors.	EWSR1 FUS	1.04e-07	3	7	2	25706482
Pubmed	The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response.	EWSR1 FUS	1.04e-07	3	7	2	18620564
Pubmed	Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3.	SERBP1 HABP4	1.04e-07	3	7	2	12505151
Pubmed	O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry.	EWSR1 FUS	1.04e-07	3	7	2	27903134
Pubmed	mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.	EWSR1 FUS	1.04e-07	3	7	2	21344536
Pubmed	A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins.	EWSR1 FUS	1.04e-07	3	7	2	23975937
Pubmed	A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions.	EWSR1 FUS	1.04e-07	3	7	2	28505004
Pubmed	FUS-NFATC2 or EWSR1-NFATC2 Fusions Are Present in a Large Proportion of Simple Bone Cysts.	EWSR1 FUS	1.04e-07	3	7	2	32991339
Pubmed	Ewing sarcoma with ERG gene rearrangements: A molecular study focusing on the prevalence of FUS-ERG and common pitfalls in detecting EWSR1-ERG fusions by FISH.	EWSR1 FUS	1.04e-07	3	7	2	26690869
Pubmed	Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions.	EWSR1 FUS	1.04e-07	3	7	2	23049996
Pubmed	Characterization of a new brain-specific isoform of the EWS oncoprotein.	EWSR1 FUS	1.04e-07	3	7	2	11422378
Pubmed	Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.	EWSR1 FUS	1.04e-07	3	7	2	27311318
Pubmed	FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.	EWSR1 FUS	1.04e-07	3	7	2	21856723
Pubmed	Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.	EWSR1 FUS	1.04e-07	3	7	2	38168093
Pubmed	Unclassified low grade spindle cell sarcoma with storiform pattern characterized by recurrent novel EWSR1/FUS-NACC1 fusions.	EWSR1 FUS	1.04e-07	3	7	2	33859361
Pubmed	Role of FET proteins in neurodegenerative disorders.	EWSR1 FUS	1.04e-07	3	7	2	27415968
Pubmed	Cytokeratin-positive Malignant Tumor in the Abdomen With EWSR1/FUS-CREB Fusion: A Clinicopathologic Study of 8 Cases.	EWSR1 FUS	1.04e-07	3	7	2	34049318
Pubmed	Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.	EWSR1 SERBP1 FUS LSM4	1.05e-07	260	7	4	36199071
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	EWSR1 SERBP1 FUS LSM4	1.54e-07	286	7	4	32041737
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	CHTOP EWSR1 SERBP1 FUS ZC3H4	1.71e-07	847	7	5	35850772
Pubmed	Characterization of TFG in mus musculus and Caenorhabditis elegans.	EWSR1 FUS	2.08e-07	4	7	2	10092511
Pubmed	Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation.	EWSR1 FUS	2.08e-07	4	7	2	28453628
Pubmed	The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex.	EWSR1 FUS	2.08e-07	4	7	2	30398641
Pubmed	The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.	EWSR1 FUS	2.08e-07	4	7	2	9660765
Pubmed	Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.	CHTOP EWSR1 SERBP1 FUS	2.79e-07	332	7	4	30595499
Pubmed	IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.	EWSR1 FUS	3.47e-07	5	7	2	18648544
Pubmed	Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.	EWSR1 FUS	5.21e-07	6	7	2	18509338
Pubmed	The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.	EWSR1 FUS	5.21e-07	6	7	2	30354839
Pubmed	A tudor domain protein SPINDLIN1 interacts with the mRNA-binding protein SERBP1 and is involved in mouse oocyte meiotic resumption.	SERBP1 HABP4	7.29e-07	7	7	2	23894536
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	CHTOP EWSR1 SERBP1 FUS LSM4	7.89e-07	1153	7	5	29845934
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CHTOP SERBP1 FUS ZC3H4 LSM4	7.95e-07	1155	7	5	20360068
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	EWSR1 FUS ZC3H4 LSM4	9.64e-07	453	7	4	29656893
Pubmed	Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.	CHTOP SERBP1	1.25e-06	9	7	2	19858291
Pubmed	UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.	CHTOP SERBP1 LSM4 HABP4	1.33e-06	491	7	4	36273042
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	CHTOP SERBP1 FUS ZC3H4	1.50e-06	506	7	4	30890647
Pubmed	Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics.	EWSR1 FUS	1.56e-06	10	7	2	21956701
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	CHTOP EWSR1 SERBP1 FUS LSM4	1.63e-06	1335	7	5	29229926
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	EWSR1 SERBP1 FUS ZC3H4 LSM4	2.17e-06	1415	7	5	28515276
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	SERBP1 FUS LSM4	2.56e-06	147	7	3	28977470
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	CHTOP EWSR1 SERBP1 FUS	3.04e-06	605	7	4	28977666
Pubmed	RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.	SERBP1 FUS ZC3H4	3.06e-06	156	7	3	26170170
Pubmed	Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins.	SERBP1 HABP4	3.16e-06	14	7	2	16455055
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	CHTOP EWSR1 FUS ZC3H4	4.12e-06	653	7	4	33742100
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	CHTOP EWSR1 SERBP1 FUS	5.46e-06	701	7	4	30196744
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	EWSR1 SERBP1 FUS HABP4	5.55e-06	704	7	4	32994395
Pubmed	A functional reference map of the RNF8 interactome in cancer.	EWSR1 SERBP1 FUS	8.35e-06	218	7	3	35831895
Pubmed	Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.	EWSR1 FUS	8.77e-06	23	7	2	18320585
Pubmed	FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.	EWSR1 FUS	8.77e-06	23	7	2	30962207
Pubmed	GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.	EWSR1 SERBP1 FUS	8.93e-06	223	7	3	33731348
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	CHTOP EWSR1 SERBP1 FUS	9.52e-06	807	7	4	30575818
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	CHTOP EWSR1 SERBP1 FUS	9.62e-06	809	7	4	32129710
Pubmed	Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.	EWSR1 FUS	1.51e-05	30	7	2	15782174
Pubmed	Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.	EWSR1 SERBP1 FUS	1.57e-05	269	7	3	30442662
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	EWSR1 FUS ZC3H4	1.82e-05	283	7	3	30585729
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EWSR1 SERBP1 FUS ZC3H4	1.84e-05	954	7	4	36373674
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	SERBP1 FUS ZC3H4 LSM4	1.98e-05	971	7	4	33306668
Pubmed	Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.	EWSR1 SERBP1 FUS	2.06e-05	295	7	3	26209609
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CHTOP EWSR1 FUS ZC3H4	2.44e-05	1024	7	4	24711643
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	EWSR1 SERBP1 FUS	2.65e-05	321	7	3	32098917
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	SERBP1 FUS HABP4	2.85e-05	329	7	3	34316702
Pubmed	ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.	EWSR1 SERBP1 FUS	3.04e-05	336	7	3	31253590
Pubmed	A Y2H-seq approach defines the human protein methyltransferase interactome.	EWSR1 SERBP1 FUS	3.20e-05	342	7	3	23455924
Pubmed	hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.	EWSR1 SERBP1 FUS	3.32e-05	346	7	3	25324306
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	EWSR1 FUS LSM4	3.35e-05	347	7	3	16033648
Pubmed	SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.	CHTOP SERBP1 FUS	3.52e-05	353	7	3	27545878
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	EWSR1 SERBP1 FUS ZC3H4	3.83e-05	1149	7	4	35446349
Pubmed	The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.	EWSR1 FUS	4.94e-05	54	7	2	18495661
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	CHTOP EWSR1 FUS	5.11e-05	400	7	3	35013556
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	CHTOP EWSR1 FUS	5.14e-05	401	7	3	25852190
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CHTOP EWSR1 SERBP1 FUS	5.28e-05	1247	7	4	27684187
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	EWSR1 SERBP1 FUS LSM4	5.45e-05	1257	7	4	37317656
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CHTOP EWSR1 SERBP1 FUS	5.45e-05	1257	7	4	36526897
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	EWSR1 SERBP1 FUS LSM4	5.92e-05	1284	7	4	17353931
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	EWSR1 SERBP1 FUS	5.95e-05	421	7	3	34650049
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CHTOP EWSR1 FUS LSM4	6.10e-05	1294	7	4	30804502
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	CHTOP EWSR1 FUS	6.33e-05	430	7	3	38172120
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CHTOP EWSR1 SERBP1 HABP4	7.65e-05	1371	7	4	36244648
Pubmed	Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.	EWSR1 FUS	8.09e-05	69	7	2	32238831
Pubmed	CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.	SERBP1 LSM4 HABP4	8.14e-05	468	7	3	36042349
Pubmed	LINKIN, a new transmembrane protein necessary for cell adhesion.	EWSR1 SERBP1 FUS	8.77e-05	480	7	3	25437307
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	EWSR1 SERBP1 ZC3H4	9.10e-05	486	7	3	30940648
Pubmed	The SARS-CoV-2 RNA interactome.	EWSR1 SERBP1	9.31e-05	74	7	2	33989516
Pubmed	Luzp4 defines a new mRNA export pathway in cancer cells.	CHTOP FUS	1.09e-04	80	7	2	25662211
Pubmed	Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.	SERBP1 FUS	1.20e-04	84	7	2	19135240
Interaction	SNRPC interactions	CHTOP EWSR1 SERBP1 FUS LSM4 HABP4	7.20e-10	440	7	6	int:SNRPC
Interaction	MYCN interactions	CHTOP EWSR1 SERBP1 FUS ZC3H4 LSM4 HABP4	6.72e-09	1373	7	7	int:MYCN
Interaction	BMI1 interactions	CHTOP EWSR1 SERBP1 FUS ZC3H4 HABP4	8.14e-09	659	7	6	int:BMI1
Interaction	PRMT8 interactions	CHTOP EWSR1 SERBP1 FUS	2.31e-08	104	7	4	int:PRMT8
Interaction	SNRPF interactions	CHTOP EWSR1 SERBP1 FUS LSM4	5.05e-08	385	7	5	int:SNRPF
Interaction	PRMT1 interactions	CHTOP EWSR1 SERBP1 FUS ZC3H4 HABP4	6.35e-08	929	7	6	int:PRMT1
Interaction	SNRNP70 interactions	CHTOP EWSR1 SERBP1 FUS ZC3H4 LSM4	8.96e-08	984	7	6	int:SNRNP70
Interaction	TOE1 interactions	EWSR1 SERBP1 FUS LSM4	9.10e-08	146	7	4	int:TOE1
Interaction	PRMT5 interactions	CHTOP EWSR1 SERBP1 FUS LSM4	1.38e-07	471	7	5	int:PRMT5
Interaction	SNRPA interactions	CHTOP EWSR1 FUS ZC3H4 LSM4	1.55e-07	482	7	5	int:SNRPA
Interaction	LARP7 interactions	CHTOP EWSR1 SERBP1 FUS LSM4 HABP4	1.87e-07	1113	7	6	int:LARP7
Interaction	SNRPB interactions	CHTOP EWSR1 FUS ZC3H4 LSM4	2.19e-07	517	7	5	int:SNRPB
Interaction	CPSF6 interactions	CHTOP EWSR1 FUS ZC3H4 LSM4	2.39e-07	526	7	5	int:CPSF6
Interaction	TDRD3 interactions	EWSR1 SERBP1 FUS LSM4	4.06e-07	212	7	4	int:TDRD3
Interaction	SNRPB2 interactions	EWSR1 SERBP1 FUS LSM4	8.51e-07	255	7	4	int:SNRPB2
Interaction	RNF113A interactions	CHTOP EWSR1 SERBP1 FUS ZC3H4	9.33e-07	692	7	5	int:RNF113A
Interaction	SYNCRIP interactions	EWSR1 SERBP1 FUS LSM4 HABP4	1.14e-06	721	7	5	int:SYNCRIP
Interaction	PRPF3 interactions	SERBP1 FUS LSM4 HABP4	1.44e-06	291	7	4	int:PRPF3
Interaction	COPRS interactions	CHTOP EWSR1 LSM4	1.45e-06	71	7	3	int:COPRS
Interaction	FUS interactions	EWSR1 SERBP1 FUS ZC3H4 LSM4	1.46e-06	757	7	5	int:FUS
Interaction	CHD3 interactions	CHTOP EWSR1 SERBP1 FUS HABP4	1.46e-06	757	7	5	int:CHD3
Interaction	GEMIN6 interactions	CHTOP FUS LSM4	1.51e-06	72	7	3	int:GEMIN6
Interaction	SMN1 interactions	CHTOP EWSR1 FUS LSM4	1.60e-06	299	7	4	int:SMN1
Interaction	PRP4K interactions	CHTOP SERBP1 LSM4 HABP4	2.35e-06	329	7	4	int:PRP4K
Interaction	ZFYVE21 interactions	EWSR1 SERBP1 FUS	2.42e-06	84	7	3	int:ZFYVE21
Interaction	MEPCE interactions	CHTOP EWSR1 SERBP1 FUS LSM4	2.72e-06	859	7	5	int:MEPCE
Interaction	TFE3 interactions	CHTOP EWSR1 SERBP1 FUS	2.80e-06	344	7	4	int:TFE3
Interaction	FBP1 interactions	EWSR1 SERBP1 FUS LSM4	2.94e-06	348	7	4	int:FBP1
Interaction	ZC3H18 interactions	CHTOP EWSR1 FUS ZC3H4 LSM4	3.01e-06	877	7	5	int:ZC3H18
Interaction	WDR77 interactions	CHTOP SERBP1 FUS LSM4	3.40e-06	361	7	4	int:WDR77
Interaction	HEXIM1 interactions	CHTOP EWSR1 SERBP1 FUS LSM4	3.67e-06	913	7	5	int:HEXIM1
Interaction	WBP4 interactions	EWSR1 FUS LSM4	5.30e-06	109	7	3	int:WBP4
Interaction	ALYREF interactions	CHTOP EWSR1 FUS LSM4	5.96e-06	416	7	4	int:ALYREF
Interaction	RNF8 interactions	CHTOP EWSR1 SERBP1 FUS	6.25e-06	421	7	4	int:RNF8
Interaction	SMNDC1 interactions	EWSR1 SERBP1 HABP4	6.40e-06	116	7	3	int:SMNDC1
Interaction	HPRT1 interactions	EWSR1 SERBP1 FUS	8.01e-06	125	7	3	int:HPRT1
Interaction	KHDRBS2 interactions	CHTOP EWSR1 SERBP1	8.80e-06	129	7	3	int:KHDRBS2
Interaction	WDR5 interactions	CHTOP EWSR1 SERBP1 FUS LSM4	9.24e-06	1101	7	5	int:WDR5
Interaction	PPIL1 interactions	EWSR1 FUS LSM4	1.30e-05	147	7	3	int:PPIL1
Interaction	SAE1 interactions	EWSR1 SERBP1 FUS	1.53e-05	155	7	3	int:SAE1
Interaction	TP53BP1 interactions	EWSR1 FUS ZC3H4 LSM4	1.59e-05	533	7	4	int:TP53BP1
Interaction	HNRNPR interactions	EWSR1 SERBP1 FUS LSM4	1.62e-05	536	7	4	int:HNRNPR
Interaction	FMR1 interactions	CHTOP EWSR1 SERBP1 HABP4	1.62e-05	536	7	4	int:FMR1
Interaction	GOT2 interactions	EWSR1 SERBP1 FUS	1.71e-05	161	7	3	int:GOT2
Interaction	CAPN13 interactions	EWSR1 ZC3H4	1.76e-05	19	7	2	int:CAPN13
Interaction	POLR3A interactions	EWSR1 SERBP1 HABP4	1.78e-05	163	7	3	int:POLR3A
Interaction	METTL14 interactions	EWSR1 SERBP1 FUS LSM4	1.90e-05	558	7	4	int:METTL14
Interaction	SF3B3 interactions	EWSR1 SERBP1 FUS LSM4	1.90e-05	558	7	4	int:SF3B3
Interaction	SARNP interactions	CHTOP EWSR1 FUS	1.94e-05	168	7	3	int:SARNP
Interaction	DDX55 interactions	SERBP1 ZC3H4 HABP4	1.98e-05	169	7	3	int:DDX55
Interaction	SF3B1 interactions	EWSR1 SERBP1 FUS LSM4	2.09e-05	571	7	4	int:SF3B1
Interaction	RNU1-1 interactions	EWSR1 FUS	2.16e-05	21	7	2	int:RNU1-1
Interaction	DIDO1 interactions	SERBP1 FUS HABP4	2.23e-05	176	7	3	int:DIDO1
Interaction	APOBEC3C interactions	CHTOP SERBP1 HABP4	2.68e-05	187	7	3	int:APOBEC3C
Interaction	HSF1 interactions	CHTOP EWSR1 SERBP1 FUS	2.69e-05	609	7	4	int:HSF1
Interaction	RECQL4 interactions	CHTOP EWSR1 SERBP1 FUS LSM4	3.12e-05	1412	7	5	int:RECQL4
Interaction	PWP1 interactions	EWSR1 SERBP1 HABP4	3.18e-05	198	7	3	int:PWP1
Interaction	SNRNP40 interactions	EWSR1 FUS ZC3H4 LSM4	3.21e-05	637	7	4	int:SNRNP40
Interaction	SOX2 interactions	CHTOP EWSR1 SERBP1 FUS LSM4	3.23e-05	1422	7	5	int:SOX2
Interaction	PSIP1 interactions	EWSR1 SERBP1 HABP4	3.52e-05	205	7	3	int:PSIP1
Interaction	EFTUD2 interactions	EWSR1 SERBP1 FUS ZC3H4 LSM4	3.55e-05	1449	7	5	int:EFTUD2
Interaction	TCERG1 interactions	SERBP1 FUS LSM4	3.63e-05	207	7	3	int:TCERG1
Interaction	RBM45 interactions	EWSR1 FUS ZC3H4	3.63e-05	207	7	3	int:RBM45
Interaction	PAF1 interactions	SERBP1 FUS ZC3H4	4.00e-05	214	7	3	int:PAF1
Interaction	RC3H1 interactions	EWSR1 SERBP1 FUS ZC3H4	4.07e-05	677	7	4	int:RC3H1
Interaction	SEC13 interactions	EWSR1 SERBP1 FUS	4.12e-05	216	7	3	int:SEC13
Interaction	SELENOI interactions	EWSR1 SERBP1	4.48e-05	30	7	2	int:SELENOI
Interaction	ACTC1 interactions	CHTOP SERBP1 FUS ZC3H4	4.49e-05	694	7	4	int:ACTC1
Interaction	SRSF9 interactions	EWSR1 FUS HABP4	4.59e-05	224	7	3	int:SRSF9
Interaction	DDX20 interactions	EWSR1 FUS LSM4	4.59e-05	224	7	3	int:DDX20
Interaction	ACAT1 interactions	EWSR1 SERBP1 FUS	5.09e-05	232	7	3	int:ACAT1
Interaction	RPRD1B interactions	EWSR1 SERBP1 FUS	5.16e-05	233	7	3	int:RPRD1B
Interaction	KIF2A interactions	EWSR1 SERBP1 HABP4	5.78e-05	242	7	3	int:KIF2A
Interaction	YBX1 interactions	EWSR1 SERBP1 FUS HABP4	6.15e-05	752	7	4	int:YBX1
Interaction	GAGE2E interactions	ZC3H4 HABP4	6.48e-05	36	7	2	int:GAGE2E
Interaction	BTRC interactions	EWSR1 SERBP1 FUS LSM4	6.92e-05	775	7	4	int:BTRC
Interaction	RPS6KB2 interactions	EWSR1 SERBP1 FUS	7.23e-05	261	7	3	int:RPS6KB2
Interaction	PICALM interactions	EWSR1 SERBP1 FUS	7.40e-05	263	7	3	int:PICALM
Interaction	UBE2O interactions	CHTOP SERBP1 LSM4 HABP4	7.46e-05	790	7	4	int:UBE2O
Interaction	NKD2 interactions	EWSR1 FUS	8.02e-05	40	7	2	int:NKD2
Interaction	CBR3 interactions	EWSR1 SERBP1	8.02e-05	40	7	2	int:CBR3
Interaction	METTL3 interactions	EWSR1 FUS LSM4	9.59e-05	287	7	3	int:METTL3
Interaction	CELF1 interactions	EWSR1 FUS ZC3H4	9.69e-05	288	7	3	int:CELF1
Interaction	AHCY interactions	EWSR1 SERBP1 FUS	1.02e-04	293	7	3	int:AHCY
Interaction	DNAJC9 interactions	SERBP1 LSM4 HABP4	1.05e-04	296	7	3	int:DNAJC9
Interaction	FUBP3 interactions	SERBP1 FUS LSM4	1.06e-04	297	7	3	int:FUBP3
Interaction	UBAP2L interactions	EWSR1 SERBP1 FUS	1.07e-04	298	7	3	int:UBAP2L
Interaction	SRSF4 interactions	EWSR1 SERBP1 FUS	1.09e-04	300	7	3	int:SRSF4
Interaction	EIF4ENIF1 interactions	EWSR1 SERBP1 LSM4	1.09e-04	300	7	3	int:EIF4ENIF1
Interaction	C1orf35 interactions	EWSR1 SERBP1 HABP4	1.14e-04	304	7	3	int:C1orf35
Interaction	SNRPE interactions	EWSR1 FUS LSM4	1.15e-04	305	7	3	int:SNRPE
Interaction	PPIA interactions	EWSR1 SERBP1 FUS ZC3H4	1.18e-04	888	7	4	int:PPIA
Interaction	AMOT interactions	EWSR1 SERBP1 FUS	1.23e-04	312	7	3	int:AMOT
Interaction	ARIH2 interactions	EWSR1 SERBP1 FUS	1.25e-04	314	7	3	int:ARIH2
Interaction	OBSL1 interactions	CHTOP EWSR1 FUS ZC3H4	1.25e-04	902	7	4	int:OBSL1
Interaction	XRCC6 interactions	EWSR1 SERBP1 FUS ZC3H4	1.40e-04	928	7	4	int:XRCC6
Interaction	LDHB interactions	EWSR1 SERBP1 FUS	1.41e-04	327	7	3	int:LDHB
Interaction	AGR2 interactions	CHTOP EWSR1 SERBP1 FUS	1.43e-04	934	7	4	int:AGR2
Interaction	CHD4 interactions	CHTOP EWSR1 SERBP1 FUS	1.46e-04	938	7	4	int:CHD4
Interaction	HNRNPA1 interactions	CHTOP EWSR1 FUS ZC3H4	1.50e-04	945	7	4	int:HNRNPA1
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	EWSR1 FUS	3.85e-06	21	3	2	89
GeneFamily	RNA binding motif containing	EWSR1 FUS	4.11e-04	213	3	2	725
Coexpression	TABULA_MURIS_SENIS_SPLEEN_PROERYTHROBLAST_AGEING	CHTOP EWSR1 SERBP1 FUS LSM4	3.06e-06	1144	7	5	MM3843
Coexpression	TABULA_MURIS_SENIS_LARGE_INTESTINE_SECRETORY_CELL_AGEING	CHTOP EWSR1 SERBP1 FUS	2.00e-05	734	7	4	MM3740
Coexpression	MUELLER_PLURINET	EWSR1 FUS LSM4	4.97e-05	299	7	3	M123
Coexpression	PUJANA_ATM_PCC_NETWORK	EWSR1 SERBP1 FUS ZC3H4	2.45e-04	1394	7	4	M9585
Coexpression	TIEN_INTESTINE_PROBIOTICS_24HR_UP	CHTOP FUS LSM4	3.20e-04	561	7	3	M1463
Coexpression	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	FUS LSM4	3.81e-04	113	7	2	M5922
Coexpression	CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN	CHTOP SERBP1 FUS	5.37e-04	669	7	3	M18635
Coexpression	TABULA_MURIS_SENIS_MESENTERIC_ADIPOSE_TISSUE_MESENCHYMAL_STEM_CELL_OF_ADIPOSE_AGEING	EWSR1 SERBP1 FUS	5.75e-04	685	7	3	MM3782
Coexpression	GAUTAM_EYE_CHOROID_SCLERA_CHOROID_ENDOTHELIAL_CELLS	FUS LSM4	5.93e-04	141	7	2	M43612
Coexpression	ZHANG_UTERUS_C7_EPITHELIAL2_CELL	EWSR1 SERBP1 LSM4	9.01e-04	799	7	3	MM16613
Coexpression	GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN	CHTOP EWSR1	1.01e-03	184	7	2	M19988
Coexpression	GSE3982_MAC_VS_NEUTROPHIL_DN	CHTOP EWSR1	1.13e-03	195	7	2	M5492
Coexpression	GSE17721_0.5H_VS_8H_LPS_BMDC_UP	LSM4 HABP4	1.17e-03	199	7	2	M4074
Coexpression	GSE14308_TH17_VS_NAIVE_CD4_TCELL_DN	EWSR1 FUS	1.17e-03	199	7	2	M3384
Coexpression	GSE37301_LYMPHOID_PRIMED_MPP_VS_RAG2_KO_NK_CELL_UP	SERBP1 FUS	1.17e-03	199	7	2	M8863
Coexpression	GSE12845_IGD_NEG_BLOOD_VS_DARKZONE_GC_TONSIL_BCELL_DN	CHTOP SERBP1	1.17e-03	199	7	2	M3197
Coexpression	GSE22432_CONVENTIONAL_CDC_VS_PLASMACYTOID_PDC_UP	SERBP1 FUS	1.17e-03	199	7	2	M7811
Coexpression	GSE1460_CORD_VS_ADULT_BLOOD_NAIVE_CD4_TCELL_DN	FUS HABP4	1.17e-03	199	7	2	M3481
Coexpression	JOHNSTONE_PARVB_TARGETS_3_DN	CHTOP EWSR1 ZC3H4	1.18e-03	877	7	3	M2241
Coexpression	GSE27786_BCELL_VS_NKCELL_UP	FUS LSM4	1.19e-03	200	7	2	M4805
Coexpression	GSE21927_SPLEEN_C57BL6_VS_EL4_TUMOR_BALBC_MONOCYTES_DN	SERBP1 LSM4	1.19e-03	200	7	2	M7599
Coexpression	GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_DN	CHTOP EWSR1	1.19e-03	200	7	2	M8106
Coexpression	GSE22140_GERMFREE_VS_SPF_MOUSE_CD4_TCELL_DN	EWSR1 FUS	1.19e-03	200	7	2	M7644
Coexpression	GSE17721_12H_VS_24H_CPG_BMDC_DN	SERBP1 HABP4	1.19e-03	200	7	2	M4133
Coexpression	GSE2405_0H_VS_9H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_DN	CHTOP SERBP1	1.19e-03	200	7	2	M6202
Coexpression	GSE21546_WT_VS_SAP1A_KO_ANTI_CD3_STIM_DP_THYMOCYTES_DN	FUS ZC3H4	1.19e-03	200	7	2	M7532
Coexpression	GSE21670_UNTREATED_VS_IL6_TREATED_CD4_TCELL_DN	CHTOP HABP4	1.19e-03	200	7	2	M7441
Coexpression	GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN	EWSR1 FUS	1.19e-03	200	7	2	M6587
Coexpression	GSE5589_LPS_VS_LPS_AND_IL6_STIM_MACROPHAGE_45MIN_UP	EWSR1 ZC3H4	1.19e-03	200	7	2	M6611
Coexpression	FISCHER_DREAM_TARGETS	EWSR1 FUS LSM4	1.58e-03	969	7	3	M149
Coexpression	TABULA_MURIS_SENIS_BROWN_ADIPOSE_TISSUE_MYELOID_CELL_AGEING	SERBP1 FUS	1.70e-03	240	7	2	MM3678
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5\|Striatum / BrainAtlas - Mouse McCarroll V32	EWSR1 FUS LSM4	2.29e-06	183	7	3	f20b0d71f857ac35868fd80531050ad8b6091716
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EWSR1 FUS	1.89e-04	136	7	2	0185486c39700dd2f72d79be6d283494dd8379c9
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EWSR1 FUS	1.89e-04	136	7	2	3e13dc0634f3b05e9f9e6c3193f843f62e603b78
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	CHTOP FUS	2.45e-04	155	7	2	9d53caee196b5c2bbc90c4f54f693b64d4086065
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EWSR1 FUS	3.30e-04	180	7	2	44988c34861df359a68376500c42a64fbcc4b431
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FUS HABP4	3.45e-04	184	7	2	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	facs-Thymus-Flowthrough-24m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERBP1 LSM4	3.56e-04	187	7	2	376a95ac1e38f61f8db5d23d9a905f8dae8c40b6
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CHTOP EWSR1	3.60e-04	188	7	2	8bd6f2cd1aadbd6f9ed31b160f59c1eff144e1dc
ToppCell	ASK428-Immune-NK_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	EWSR1 FUS	3.67e-04	190	7	2	d649f7e17c4227787465dfc02037f791ff85378b
ToppCell	E15.5\|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SERBP1 LSM4	3.75e-04	192	7	2	4a0fb4ef8a9281489ffb0881421c9d691c52019c
ToppCell	droplet-Marrow-BM-1m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EWSR1 FUS	3.87e-04	195	7	2	637b06ef3967b03f7165d102d316e8b7161a817d
ToppCell	10x_3'_v3\|World / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SERBP1 FUS	3.99e-04	198	7	2	aabb8e9b162ae4cb26ea860c99decdbb51e379e1
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	EWSR1 FUS	3.99e-04	198	7	2	61ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCell	C_03\|World / shred on cell type and cluster	SERBP1 LSM4	4.03e-04	199	7	2	1ae1c7152a49a5484e715a1e084f6e02bdbcaca3
ToppCell	3'-Adult-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SERBP1 LSM4	4.03e-04	199	7	2	0649a2c5b8b1f01bb4c4d1eb114cf78a32f8ccd8
ToppCell	Enterocyte_Progenitors\|World / shred on cell type and cluster	SERBP1 FUS	4.03e-04	199	7	2	776bcc887927dea9ebd76ec4338ce2225c319c2c
ToppCell	lymphoid-T_cell-CD8+_Naive_T_cell\|T_cell / Lineage, cell class and subclass	SERBP1 LSM4	4.03e-04	199	7	2	9ee40563e840a7fe97e7592539d42e19db438c64
ToppCell	10x5'v1-week_12-13-Lymphocytic_B-B_lineage-pre_pro_B_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	EWSR1 FUS	4.03e-04	199	7	2	5478b78349b5d8d57f30bb650dcbd5fdb84283d6
ToppCell	3'-Adult-LargeIntestine-Epithelial-epithelial_progenitor_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SERBP1 LSM4	4.03e-04	199	7	2	e3e28981783b922027cee7fe8863386b02c7c758
ToppCell	lymphoid-T_cell-CD8+_Naive_T_cell\|lymphoid / Lineage, cell class and subclass	SERBP1 LSM4	4.03e-04	199	7	2	22926327c93ede9f3408c99a0d56e373a33240ef
ToppCell	HSPCs\|World / Lineage and Cell class	EWSR1 SERBP1	4.03e-04	199	7	2	df1ffc416c6946f1ba182f242a50ee41a571d565
ToppCell	lymphoid-T_cell-CD8+_Naive_T_cell\|World / Lineage, cell class and subclass	SERBP1 LSM4	4.03e-04	199	7	2	4de81f29c4d79868fd6254ceb81b4ddad22ae7d0
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Radial_glial\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	SERBP1 LSM4	4.07e-04	200	7	2	9069e8d3bcc5f44baa00f2abb6cffd87586c3eab
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Radial_glial-RG\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	SERBP1 LSM4	4.07e-04	200	7	2	b3775715b66aee18cff469bf3dbe9c305671c6d6
ToppCell	Megakaryocytic-erythropoietic-Megakaryo-cells-Megakaryocyte\|Megakaryo-cells / Lineage, cell class and subclass	FUS LSM4	4.07e-04	200	7	2	f36023bb369d17b8ec8724616737738e3df01987
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma\|TCGA-Liver / Sample_Type by Project: Shred V9	CHTOP LSM4	4.07e-04	200	7	2	9cff8be6e566f342fc8b45e93106d033b14759ee
ToppCell	TCGA-Liver-Primary_Tumor\|TCGA-Liver / Sample_Type by Project: Shred V9	CHTOP LSM4	4.07e-04	200	7	2	b667168081393433597f6ca8baeddba1d1906d40
Computational	Neighborhood of FBL	SERBP1 FUS LSM4	4.20e-05	140	6	3	MORF_FBL
Computational	Neighborhood of CSNK1A1	CHTOP SERBP1	1.62e-04	36	6	2	GCM_CSNK1A1
Computational	Neighborhood of EIF3S2	SERBP1 FUS LSM4	2.25e-04	246	6	3	MORF_EIF3S2
Computational	Neighborhood of BUB3	SERBP1 FUS LSM4	3.20e-04	277	6	3	MORF_BUB3
Computational	Genes in the cancer module 14.	EWSR1 SERBP1 LSM4	6.74e-04	357	6	3	MODULE_15
Computational	Neighborhood of PA2G4	SERBP1 LSM4	7.85e-04	79	6	2	GNF2_PA2G4
Computational	Neighborhood of RAN	SERBP1 LSM4	9.29e-04	86	6	2	GNF2_RAN
Computational	Neighborhood of APEX1	SERBP1 FUS	1.06e-03	92	6	2	GNF2_APEX1
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	CHTOP FUS LSM4	2.08e-05	194	7	3	5017_DN
Drug	2d41	EWSR1 FUS	2.83e-05	27	7	2	CID009543496
Drug	2H1H	EWSR1 FUS	3.05e-05	28	7	2	CID011527397
Drug	A-skin	EWSR1 FUS	4.00e-05	32	7	2	CID000208772
Drug	EMCs	EWSR1 FUS	4.52e-05	34	7	2	CID005091655
Drug	Nor 3	EWSR1 FUS	9.86e-05	50	7	2	CID009578441
Drug	DAPH2	EWSR1 FUS	1.33e-04	58	7	2	CID006711154
Drug	methyl red	FUS LSM4	2.93e-04	86	7	2	CID000010303
Drug	NSC648766	EWSR1 FUS	3.42e-04	93	7	2	CID000003199
Drug	bromfenacoum	EWSR1 SERBP1 HABP4	7.24e-04	644	7	3	ctd:C013418
Drug	cyclohexylammonium	EWSR1 FUS	8.51e-04	147	7	2	CID000007965
Drug	AC1L1AUZ	EWSR1 FUS	9.70e-04	157	7	2	CID000001160
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	CHTOP ZC3H4	1.04e-03	163	7	2	7453_DN
Drug	P-NE	EWSR1 FUS	1.12e-03	169	7	2	CID000446755
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	CHTOP ZC3H4	1.14e-03	170	7	2	3791_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA	CHTOP ZC3H4	1.16e-03	172	7	2	1072_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	CHTOP ZC3H4	1.19e-03	174	7	2	7105_DN
Drug	AC1NRA5C	EWSR1 FUS	1.19e-03	174	7	2	CID005287709
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	CHTOP ZC3H4	1.19e-03	174	7	2	5745_DN
Drug	14-deoxy-11,12-didehydroandrographolide	EWSR1 FUS	1.20e-03	175	7	2	ctd:C495626
Drug	SAHA; Down 200; 10uM; MCF7; HT_HG-U133A	CHTOP ZC3H4	1.22e-03	176	7	2	6980_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	CHTOP ZC3H4	1.22e-03	176	7	2	4632_DN
Drug	trichostatin A ; Down 200; 1uM; MCF7; HT_HG-U133A_EA	CHTOP ZC3H4	1.22e-03	176	7	2	981_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	CHTOP ZC3H4	1.23e-03	177	7	2	6340_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	CHTOP ZC3H4	1.24e-03	178	7	2	1112_DN
Drug	scriptaid; Down 200; 10uM; MCF7; HT_HG-U133A	CHTOP ZC3H4	1.26e-03	179	7	2	6901_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	ZC3H4 LSM4	1.26e-03	179	7	2	6910_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	CHTOP ZC3H4	1.29e-03	181	7	2	7005_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HG-U133A	CHTOP ZC3H4	1.30e-03	182	7	2	1951_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	ZC3H4 LSM4	1.33e-03	184	7	2	6916_DN
Drug	Metoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; HL60; HT_HG-U133A	CHTOP FUS	1.36e-03	186	7	2	2353_DN
Drug	AG-1478; Down 200; 31.6uM; MCF7; HT_HG-U133A_EA	CHTOP FUS	1.37e-03	187	7	2	1141_DN
Drug	Ethotoin [86-35-1]; Down 200; 19.6uM; PC3; HT_HG-U133A	CHTOP FUS	1.39e-03	188	7	2	4545_DN
Drug	AG-012559 [369370-06-9]; Down 200; 10uM; PC3; HT_HG-U133A	FUS LSM4	1.40e-03	189	7	2	6920_DN
Drug	Deptropine citrate [2169-75-7]; Down 200; 7.6uM; HL60; HT_HG-U133A	FUS LSM4	1.42e-03	190	7	2	3144_DN
Drug	Prostaglandin E1; Up 200; 10uM; PC3; HT_HG-U133A	FUS LSM4	1.42e-03	190	7	2	6571_UP
Drug	Pyrimethamine [58-14-0]; Down 200; 16uM; HL60; HG-U133A	FUS LSM4	1.42e-03	190	7	2	1974_DN
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; MCF7; HT_HG-U133A	FUS LSM4	1.42e-03	190	7	2	6912_DN
Drug	2-propylpentanoic acid; Down 200; 200uM; HL60; HT_HG-U133A	FUS LSM4	1.43e-03	191	7	2	6173_DN
Drug	PNU-0293363 [326823-19-2]; Up 200; 10uM; MCF7; HT_HG-U133A	FUS LSM4	1.44e-03	192	7	2	6573_UP
Drug	Fusaric acid [536-69-6]; Down 200; 22.4uM; MCF7; HT_HG-U133A	FUS HABP4	1.44e-03	192	7	2	3245_DN
Drug	Metanephrine hydrochloride DL [881-95-8]; Down 200; 17.2uM; HL60; HG-U133A	FUS LSM4	1.46e-03	193	7	2	2015_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A	FUS HABP4	1.46e-03	193	7	2	3841_DN
Drug	Bendroflumethiazide [73-48-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	FUS HABP4	1.47e-03	194	7	2	3840_DN
Drug	Domperidone maleate; Down 200; 7.4uM; MCF7; HT_HG-U133A	FUS LSM4	1.47e-03	194	7	2	2655_DN
Drug	Captopril [62571-86-2]; Down 200; 17.2uM; HL60; HG-U133A	FUS LSM4	1.47e-03	194	7	2	1988_DN
Drug	Procainamide hydrochloride [614-39-1]; Down 200; 14.8uM; PC3; HT_HG-U133A	CHTOP FUS	1.47e-03	194	7	2	4602_DN
Drug	Amprolium hydrochloride [137-88-2]; Down 200; 12.6uM; HL60; HG-U133A	FUS LSM4	1.49e-03	195	7	2	1979_DN
Drug	PHA-00665752 [477575-56-7]; Down 200; 10uM; MCF7; HT_HG-U133A	FUS LSM4	1.49e-03	195	7	2	6578_DN
Drug	STOCK1N-28457; Down 200; 20uM; MCF7; HT_HG-U133A	FUS LSM4	1.49e-03	195	7	2	6906_DN
Drug	Famprofazone [22881-35-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A	CHTOP FUS	1.49e-03	195	7	2	3834_DN
Drug	Tolazoline hydrochloride [59-97-2]; Down 200; 20.4uM; HL60; HG-U133A	EWSR1 FUS	1.49e-03	195	7	2	2000_DN
Drug	PHA-00767505E [723337-45-9]; Up 200; 10uM; PC3; HT_HG-U133A	FUS LSM4	1.50e-03	196	7	2	6591_UP
Drug	PNU-0293363 [326823-19-2]; Up 200; 10uM; PC3; HT_HG-U133A	CHTOP LSM4	1.50e-03	196	7	2	6568_UP
Drug	Hydrochlorothiazide [58-93-5]; Down 200; 13.4uM; PC3; HG-U133A	CHTOP FUS	1.50e-03	196	7	2	1906_DN
Drug	16, 16-dimethylprostaglandin E2 methyl acetate solution; Down 200; 10uM; PC3; HT_HG-U133A	FUS LSM4	1.50e-03	196	7	2	6562_DN
Drug	Berberine chloride [633-65-8]; Down 200; 10.8uM; MCF7; HT_HG-U133A	CHTOP HABP4	1.50e-03	196	7	2	2770_DN
Drug	benserazide hydrochloride; Down 200; 10uM; SKMEL5; HG-U133A	FUS HABP4	1.50e-03	196	7	2	631_DN
Drug	Gly-His-Lys acetate salt; Up 200; 1uM; PC3; HT_HG-U133A	FUS LSM4	1.50e-03	196	7	2	6570_UP
Drug	Naproxen [22204-53-1]; Down 200; 17.4uM; PC3; HT_HG-U133A	FUS LSM4	1.52e-03	197	7	2	1828_DN
Drug	fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A_EA	EWSR1 FUS	1.52e-03	197	7	2	1075_DN
Drug	0175029-0000 [211245-78-2]; Down 200; 1uM; PC3; HT_HG-U133A	ZC3H4 HABP4	1.52e-03	197	7	2	3694_DN
Drug	NS-398; Down 200; 10uM; MCF7; HT_HG-U133A	FUS LSM4	1.52e-03	197	7	2	6911_DN
Drug	Metergoline [17692-51-2]; Down 200; 10uM; MCF7; HT_HG-U133A	FUS LSM4	1.52e-03	197	7	2	5344_DN
Drug	Vincamine [1617-90-9]; Down 200; 11.2uM; MCF7; HT_HG-U133A	CHTOP FUS	1.52e-03	197	7	2	3865_DN
Drug	STOCK1N-28457; Down 200; 20uM; PC3; HT_HG-U133A	FUS HABP4	1.54e-03	198	7	2	6864_DN
Drug	Carcinine [56897-53-1]; Down 200; 22uM; MCF7; HT_HG-U133A	FUS LSM4	1.54e-03	198	7	2	4809_DN
Drug	Saquinavir mesylate [149845-06-7]; Down 200; 5.2uM; MCF7; HT_HG-U133A	FUS LSM4	1.54e-03	198	7	2	6246_DN
Drug	S-adenosyl-D-homocysteine	EWSR1 LSM4	1.92e-03	222	7	2	CID000000193
Drug	12 p	EWSR1 FUS	2.91e-03	274	7	2	CID000081248
Disease	amyotrophic lateral sclerosis type 6 (implicated_via_orthology)	EWSR1 FUS	1.45e-07	3	7	2	DOID:0060198 (implicated_via_orthology)
Disease	frontotemporal dementia (implicated_via_orthology)	EWSR1 FUS	3.18e-06	12	7	2	DOID:9255 (implicated_via_orthology)
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	EWSR1 FUS	2.09e-05	30	7	2	DOID:332 (implicated_via_orthology)
Disease	Amyotrophic Lateral Sclerosis	EWSR1 FUS	7.92e-05	58	7	2	C0002736
Disease	body surface area	ZC3H4 LSM4 HABP4	3.38e-04	643	7	3	EFO_0022196
Disease	smoking behavior, body mass index	ZC3H4 LSM4	3.57e-04	123	7	2	EFO_0004318, EFO_0004340
Disease	platelet component distribution width	EWSR1 LSM4 HABP4	5.41e-04	755	7	3	EFO_0007984
Disease	red blood cell density measurement	ZC3H4 LSM4	1.69e-02	880	7	2	EFO_0007978
Disease	platelet crit	CHTOP HABP4	1.96e-02	952	7	2	EFO_0007985
Disease	reticulocyte count	ZC3H4 LSM4	2.34e-02	1045	7	2	EFO_0007986

Protein segments in the cluster

Peptide	Gene	Start	Entry
GFDRGGMSRGGRGGG	EWSR1	306	Q01844
GMSRGGRGGGRGGMG	EWSR1	311	Q01844
GRGGGRGGMGSAGER	EWSR1	316	Q01844
GGPMGRMGGRGGDRG	EWSR1	481	Q01844
GDRGRGGPGGMRGGR	EWSR1	561	Q01844
MRGGRGGLMDRGGPG	EWSR1	571	Q01844
RGGPGGMFRGGRGGD	EWSR1	581	Q01844
GMFRGGRGGDRGGFR	EWSR1	586	Q01844
GRGGDRGGFRGGRGM	EWSR1	591	Q01844
RGGFRGGRGMDRGGF	EWSR1	596	Q01844
GGRGMDRGGFGGGRR	EWSR1	601	Q01844
GGLGRGRGGRGRGMG	SERBP1	166	Q8NC51
GRGGRGRGMGRGDGF	SERBP1	171	Q8NC51
PRGRGGGRGGRGGMG	FUS	241	P35637
GGRGGRGGMGGSDRG	FUS	246	P35637
NGRGGRGRGGPMGRG	FUS	381	P35637
RGRGGPMGRGGYGGG	FUS	386	P35637
GGPRGGMRGRGRGGP	HABP4	186	Q5JVS0
GRGMGGAGRGVFGGR	LSM4	101	Q9Y4Z0
GPGRGGLGRGAMGRG	CHTOP	161	Q9Y3Y2
GLGRGAMGRGGIGGR	CHTOP	166	Q9Y3Y2
GIGGRGRGMIGRGRG	CHTOP	176	Q9Y3Y2
GRGMIGRGRGGFGGR	CHTOP	181	Q9Y3Y2
GKGMGRGRGRGGSRG	ZC3H4	336	Q9UPT8