Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	KLHL2 PRAMEF9 PRAMEF15 PRAMEF27 PRAMEF11	3.10e-05	82	88	5	GO:1990756
GeneOntologyMolecularFunction	palmitoyl-CoA ligase activity	ACSL3 ACSL4	5.74e-05	3	88	2	GO:0090433
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	KLHL2 PRAMEF9 PRAMEF15 PRAMEF27 PRAMEF11	6.29e-05	95	88	5	GO:0140767
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	ZYG11A PRAMEF9 PRAMEF15 PRAMEF27 PRAMEF11	1.86e-06	47	91	5	GO:0031462
GeneOntologyCellularComponent	protein phosphatase type 2A complex	PPP2R2B PPP2R2C PPP2R2D	6.21e-05	18	91	3	GO:0000159
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	ZYG11A KLHL2 PRAMEF9 PRAMEF15 PRAMEF27 PRAMEF11	3.30e-04	212	91	6	GO:0031461
Domain	PP2A_PR55	PPP2R2B PPP2R2C PPP2R2D	4.03e-07	4	88	3	IPR000009
Domain	PP2A_PR55_CS	PPP2R2B PPP2R2C PPP2R2D	4.03e-07	4	88	3	IPR018067
Domain	PR55_2	PPP2R2B PPP2R2C PPP2R2D	4.03e-07	4	88	3	PS01025
Domain	PR55_1	PPP2R2B PPP2R2C PPP2R2D	4.03e-07	4	88	3	PS01024
Domain	ARM-type_fold	ZYG11A URB1 USP9X NBEAL2 AP3B2 TOGARAM2 INTS4 USP9Y AP3B1 KPNB1	4.38e-06	339	88	10	IPR016024
Domain	ARM-like	ZYG11A USP9X NBEAL2 AP3B2 TOGARAM2 INTS4 USP9Y AP3B1 KPNB1	5.09e-06	270	88	9	IPR011989
Domain	AP3_beta	AP3B2 AP3B1	2.19e-05	2	88	2	IPR026740
Domain	AP3B_C	AP3B2 AP3B1	2.19e-05	2	88	2	IPR029390
Domain	AP3B1_C	AP3B2 AP3B1	2.19e-05	2	88	2	PF14796
Domain	AP3B1_C	AP3B2 AP3B1	2.19e-05	2	88	2	SM01355
Domain	SH3_9	TNK2 NEB ARHGEF26 DNMBP ARHGEF16	3.33e-05	78	88	5	PF14604
Domain	-	ZYG11A USP9X AP3B2 TOGARAM2 INTS4 AP3B1 KPNB1	8.56e-05	222	88	7	1.25.10.10
Domain	PRAME_family	PRAMEF25 PRAMEF15 PRAMEF27	9.27e-05	19	88	3	IPR026271
Domain	SH3_1	TNK2 PLCG2 NEB ARHGEF26 DNMBP ARHGEF16	1.25e-04	164	88	6	PF00018
Domain	AP_beta	AP3B2 AP3B1	2.17e-04	5	88	2	IPR026739
Domain	Na-dicarboxylate_symporter	SLC1A1 SLC1A4	4.54e-04	7	88	2	IPR001991
Domain	NA_DICARBOXYL_SYMP_1	SLC1A1 SLC1A4	4.54e-04	7	88	2	PS00713
Domain	NA_DICARBOXYL_SYMP_2	SLC1A1 SLC1A4	4.54e-04	7	88	2	PS00714
Domain	Na-dicarboxylate_symporter_CS	SLC1A1 SLC1A4	4.54e-04	7	88	2	IPR018107
Domain	SDF	SLC1A1 SLC1A4	4.54e-04	7	88	2	PF00375
Domain	-	SLC1A1 SLC1A4	4.54e-04	7	88	2	1.10.3860.10
Domain	SH3	TNK2 PLCG2 NEB ARHGEF26 DNMBP ARHGEF16	5.50e-04	216	88	6	SM00326
Domain	SH3	TNK2 PLCG2 NEB ARHGEF26 DNMBP ARHGEF16	5.50e-04	216	88	6	PS50002
Domain	SH3_domain	TNK2 PLCG2 NEB ARHGEF26 DNMBP ARHGEF16	6.05e-04	220	88	6	IPR001452
Domain	DEAH_ATP_HELICASE	DHX16 DHX38 WRN	7.57e-04	38	88	3	PS00690
Domain	-	ZYG11A LRRC66 PRAMEF25 CARMIL1 LRRC20 PRAMEF15 PRAMEF27	8.01e-04	321	88	7	3.80.10.10
Domain	L_dom-like	ZYG11A LRRC66 PRAMEF25 CARMIL1 LRRC20 PRAMEF15 PRAMEF27	9.09e-04	328	88	7	IPR032675
Domain	ABC_A	ABCA3 ABCA13	1.40e-03	12	88	2	IPR026082
Domain	Clathrin/coatomer_adapt-like_N	AP3B2 AP3B1	2.21e-03	15	88	2	IPR002553
Domain	Adaptin_N	AP3B2 AP3B1	2.21e-03	15	88	2	PF01602
Domain	DUF1605	DHX16 DHX38	2.85e-03	17	88	2	IPR011709
Domain	OB_NTP_bind	DHX16 DHX38	2.85e-03	17	88	2	PF07717
Domain	HA2	DHX16 DHX38	3.20e-03	18	88	2	SM00847
Domain	HA2	DHX16 DHX38	3.20e-03	18	88	2	PF04408
Domain	Helicase-assoc_dom	DHX16 DHX38	3.20e-03	18	88	2	IPR007502
Domain	DH_1	ARHGEF26 DNMBP ARHGEF16	3.27e-03	63	88	3	PS00741
Domain	RhoGEF	ARHGEF26 DNMBP ARHGEF16	4.06e-03	68	88	3	SM00325
Domain	RhoGEF	ARHGEF26 DNMBP ARHGEF16	4.41e-03	70	88	3	PF00621
Domain	DH_2	ARHGEF26 DNMBP ARHGEF16	4.41e-03	70	88	3	PS50010
Domain	DH-domain	ARHGEF26 DNMBP ARHGEF16	4.59e-03	71	88	3	IPR000219
Domain	-	ARHGEF26 DNMBP ARHGEF16	4.59e-03	71	88	3	1.20.900.10
Domain	DEAD/DEAH_box_helicase_dom	DHX16 DHX38 WRN	4.96e-03	73	88	3	IPR011545
Domain	DEAD	DHX16 DHX38 WRN	4.96e-03	73	88	3	PF00270
Domain	AMP-binding_CS	ACSL3 ACSL4	6.63e-03	26	88	2	IPR020845
Domain	WD40	PPP2R2B PPP2R2C PPP2R2D NBEAL2 DMXL1	7.60e-03	259	88	5	PF00400
Domain	AMP_BINDING	ACSL3 ACSL4	7.66e-03	28	88	2	PS00455
Domain	WD40	PPP2R2B PPP2R2C PPP2R2D NBEAL2 DMXL1	8.73e-03	268	88	5	SM00320
Domain	AMP-binding	ACSL3 ACSL4	8.76e-03	30	88	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSL3 ACSL4	8.76e-03	30	88	2	IPR000873
Domain	WD40_repeat	PPP2R2B PPP2R2C PPP2R2D NBEAL2 DMXL1	9.27e-03	272	88	5	IPR001680
Pathway	KEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY	PPP2R2B PPP2R2C PPP2R2D	6.77e-05	19	60	3	M47525
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY	PPP2R2B PPP2R2C PPP2R2D	1.07e-04	22	60	3	M47919
Pubmed	Defining the membrane proteome of NK cells.	PKMYT1 ACSL3 ACSL4 DPY19L1 USP9X NBEAL2 MARCHF5 DHX38 PSMC5 TNK2 AP3B1 PIGU ALG6 SLC1A4 KPNB1	4.15e-07	1168	92	15	19946888
Pubmed	HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.	PPP2R2B PPP2R2C PPP2R2D	6.22e-07	7	92	3	25816751
Pubmed	Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.	PPP2R2B PPP2R2C PPP2R2D	1.49e-06	9	92	3	19762425
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	6.92e-06	2	92	2	12925892
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	6.92e-06	2	92	2	12895410
Pubmed	Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.	ACSL3 ACSL4	6.92e-06	2	92	2	32286604
Pubmed	Functional significance of N- and C-terminus of the amino acid transporters EAAC1 and ASCT1: characterization of chimeric transporters.	SLC1A1 SLC1A4	6.92e-06	2	92	2	11030592
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9X USP9Y	6.92e-06	2	92	2	8922996
Pubmed	Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion.	ACSL3 ACSL4	6.92e-06	2	92	2	28193492
Pubmed	The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.	ACSL3 ACSL4	6.92e-06	2	92	2	29450800
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	DHX16 ACSL3 USP9X DHX38 SRPK2 AP3B1 GFPT1 SCAF4 KPNB1 PTCD3	9.20e-06	653	92	10	33742100
Pubmed	Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.	PPP2R2B PPP2R2C PPP2R2D	1.68e-05	19	92	3	32582689
Pubmed	Identification of novel spartin-interactors shows spartin is a multifunctional protein.	ACSL3 ACSL4 KPNB1	1.68e-05	19	92	3	19765186
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF15 PRAMEF27 PRAMEF11	1.98e-05	20	92	3	26694250
Pubmed	The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform.	AP3B2 AP3B1	2.07e-05	3	92	2	10930456
Pubmed	Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits.	PPP2R2B PPP2R2C	2.07e-05	3	92	2	9514514
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	ACSL3 PPP2R2B PPP2R2C PPP2R2D DHX38 SCO1 INTS4 PSMC5 KPNB1	2.17e-05	573	92	9	28330616
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PITPNM2 ATP6V0C PPP2R2C SACS USP9X CARMIL1 AP3B2 NIPSNAP2 SRPK2 AP3B1 SLC1A4 UNC13A KPNB1 PTCD3	2.34e-05	1431	92	14	37142655
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF15 PRAMEF27 PRAMEF11	2.66e-05	22	92	3	31729367
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF15 PRAMEF27 PRAMEF11	3.95e-05	25	92	3	37451217
Pubmed	Regulation of large dense-core vesicle volume and neurotransmitter content mediated by adaptor protein 3.	AP3B2 AP3B1	4.14e-05	4	92	2	16788073
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	ACSL3 PPP2R2B SACS USP9X AP3B2 DHX38 AP3B1 GFPT1	5.43e-05	498	92	8	36634849
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF15 PRAMEF27 PRAMEF11	5.59e-05	28	92	3	25089626
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX16 ACSL3 URB1 USP9X DHX38 PSMC5 GFPT1 KPNB1 PTCD3	5.97e-05	653	92	9	22586326
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	ACSL3 SERPINE2 SCO1 NIPSNAP2 SRPK2	6.69e-05	159	92	5	30581152
Pubmed	Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.	AP3B2 AP3B1	6.89e-05	5	92	2	37812725
Pubmed	Association analysis between schizophrenia and the AP-3 complex genes.	AP3B2 AP3B1	6.89e-05	5	92	2	19481122
Pubmed	Activation of protein phosphatase-2A1 by HIV-1 Vpr cell death causing peptide in intact CD(4+) T cells and in vitro.	PPP2R2B PPP2R2C	6.89e-05	5	92	2	15578586
Pubmed	Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.	ACSL3 ACSL4	6.89e-05	5	92	2	15292367
Pubmed	The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.	ACSL3 ACSL4	6.89e-05	5	92	2	22633490
Pubmed	Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation.	NBEAL2 PLCG2	6.89e-05	5	92	2	32929010
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	ACSL3 ZYG11A SFXN5 PPP2R2C TMEM9 CGREF1 TNK2 PBX2 WLS SLC1A1 KPNB1	8.13e-05	1021	92	11	26760575
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	USP9X AP3B2 SCO1 NIPSNAP2 PSMC5 SRPK2 AP3B1 SCAF4 KPNB1 PTCD3	8.29e-05	847	92	10	35235311
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	PPP2R2B PPP2R2D USP9Y KPNB1	8.63e-05	87	92	4	17148452
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ATP6V0C ABCA3 SACS SLC2A6 MFSD4A WLS PIGU RGR SLC1A4	9.79e-05	697	92	9	28298427
Pubmed	Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome.	AURKAIP1 PTCD3	1.03e-04	6	92	2	23908630
Pubmed	Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.	AP3B2 AP3B1	1.03e-04	6	92	2	15537701
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF15 PRAMEF27 PRAMEF11	1.10e-04	35	92	3	19389355
Pubmed	Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.	PPP2R2B PPP2R2C KPNB1	1.20e-04	36	92	3	22422068
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	TLK2 ACSL3 ACSL4 SULT1B1 USP9X CAPN6 SRPK2 GFPT1 DMXL1	1.39e-04	730	92	9	34857952
Pubmed	Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15.	PPP2R2B PPP2R2D	1.44e-04	7	92	2	23135275
Pubmed	Characterization of the adaptor-related protein complex, AP-3.	AP3B2 AP3B1	1.44e-04	7	92	2	9151686
Pubmed	Ontogeny of mRNA expression and activity of long-chain acyl-CoA synthetase (ACSL) isoforms in Mus musculus heart.	ACSL3 ACSL4	1.44e-04	7	92	2	17197235
Pubmed	An integrated workflow for charting the human interaction proteome: insights into the PP2A system.	PPP2R2B PPP2R2C PPP2R2D KPNB1	1.79e-04	105	92	4	19156129
Pubmed	Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.	PPP2R2B PPP2R2C	1.92e-04	8	92	2	12912990
Pubmed	The role of Vpr in HIV-1 pathogenesis.	PPP2R2B PPP2R2C	1.92e-04	8	92	2	15638722
Pubmed	Association of the AP-3 adaptor complex with clathrin.	AP3B2 AP3B1	1.92e-04	8	92	2	9545220
Pubmed	A HECT domain E3 enzyme assembles novel polyubiquitin chains.	USP9X PSMC5	1.92e-04	8	92	2	11278995
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ACSL3 URB1 TMEM9 USP9X PSMC5 OCLN WLS AP3B1 GFPT1 KPNB1	1.97e-04	942	92	10	31073040
Pubmed	AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes.	AP3B2 AP3B1	2.46e-04	9	92	2	23144738
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PPP2R2C PRAMEF15 PRAMEF11	2.50e-04	46	92	3	17287250
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	SLC1A1 GFPT1 SLC4A11 GSR SCAF4	2.57e-04	212	92	5	19521566
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	KLHL2 SERPINE2 ADCK5 USP9X NIPSNAP2 PSMC5 TNK2	2.95e-04	481	92	7	28190767
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ACSL4 PPP2R2B USP9X POTEJ NEB AP3B1 PIGU GFPT1	2.96e-04	638	92	8	31182584
Pubmed	Regulation of arrestin-3 phosphorylation by casein kinase II.	AP3B2 AP3B1	3.07e-04	10	92	2	11877451
Pubmed	HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.	AP3B2 AP3B1	3.07e-04	10	92	2	18076669
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	USP9X USP9Y	3.07e-04	10	92	2	9384609
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	ACSL3 ACSL4 PPP2R2B PPP2R2D PSMC5 GFPT1 KPNB1 PTCD3	3.24e-04	647	92	8	26618866
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	USP9X NBEAL2 CARMIL1 TOGARAM2 NEB USP9Y SCAF4	3.59e-04	497	92	7	36774506
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	DHX16 PPP2R2C DHX38 PSMC5 GSR KPNB1	3.81e-04	357	92	6	37059091
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PKMYT1 ACSL4 ATG2A OCLN PIGU SLC1A1 DMXL1	3.90e-04	504	92	7	34432599
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ACSL3 ACSL4 OR13D1 SACS NIPSNAP2 DLEC1 POTEJ NEB MINDY2 SLC4A11 GSR KPNB1	4.18e-04	1442	92	12	35575683
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	SETMAR ABCA13 AP3B2 NEB MINDY2 SLC1A4 KPNB1	4.34e-04	513	92	7	25798074
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ACSL4 PPP2R2B SETMAR TMEM9 NBEAL2 MARCHF5 CARMIL1 PRAMEF15 SCO1 SLC1A4 PRAMEF11	4.40e-04	1242	92	11	30973865
Pubmed	The shieldin complex mediates 53BP1-dependent DNA repair.	ACSL3 TMEM9 DNMBP	4.49e-04	56	92	3	30022168
Pubmed	Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.	USP9X USP9Y	4.49e-04	12	92	2	23861879
Pubmed	Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.	AP3B2 AP3B1	4.49e-04	12	92	2	19144828
Pubmed	Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad.	SERPINE2 WRN KPNB1	4.73e-04	57	92	3	14595844
Pubmed	Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).	TGFBI ACSL3 SERPINE2 PSMC5 GFPT1	5.16e-04	247	92	5	39238192
Pubmed	Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes.	ACSL3 SERPINE2	5.30e-04	13	92	2	11700028
Pubmed	Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.	PPP2R2B PPP2R2C	5.30e-04	13	92	2	18971272
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PKMYT1 ACSL3 URB1 SACS SCO1 SRPK2 OCLN AP3B1 PIGU GSR DMXL1 PTCD3	5.49e-04	1487	92	12	33957083
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	USP9X CARMIL1 PSMC5 OCLN AP3B1 ARHGEF26 GFPT1 KPNB1	5.88e-04	708	92	8	39231216
Pubmed	Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.	PPP2R2B PPP2R2C	6.17e-04	14	92	2	9013886
Pubmed	Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.	PPP2R2B PPP2R2C	6.17e-04	14	92	2	9400615
Pubmed	Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.	PPP2R2B PPP2R2C	6.17e-04	14	92	2	16048649
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	ACSL3 ACSL4 ATP6V0C USP9X NIPSNAP2 WLS	6.23e-04	392	92	6	33144569
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP9X USP9Y	7.11e-04	15	92	2	9827704
Pubmed	IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.	USP9X PSMC5	7.11e-04	15	92	2	18303054
Pubmed	Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.	PPP2R2B PPP2R2C	7.11e-04	15	92	2	16041367
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	USP9X USP9Y	7.11e-04	15	92	2	14762062
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	ACSL3 INTS4 OCLN AP3B1 SCAF4 KPNB1 PTCD3	7.28e-04	560	92	7	35241646
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TLK2 ACSL3 PPP2R2D CARMIL1 WRN SCO1 PSMC5 AP3B1 PIGU SLC1A1 KPNB1	7.33e-04	1321	92	11	27173435
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	KLHL2 LRRC66 URB1 SERPINE2 USP9X NIPSNAP2 PSMC5 SCAF4 KPNB1	7.58e-04	922	92	9	27609421
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	PKMYT1 TLK2 ACSL3 BTBD7 USP9X MARCHF5 LRRC20 DHX38 ALG6 GFPT1 GSR	7.60e-04	1327	92	11	32694731
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	NBEAL2 CARMIL1 OCLN WLS ARHGEF26 ARHGEF16 SLC1A4	7.99e-04	569	92	7	30639242
Pubmed	CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase.	USP9X PSMC5	8.11e-04	16	92	2	29979702
Pubmed	Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles.	AP3B2 AP3B1	8.11e-04	16	92	2	23247405
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	ACSL4 SFXN5 ADCK5 CYP11B2 MARCHF5 SCO1 NIPSNAP2 AURKAIP1 GSR PTCD3	8.49e-04	1136	92	10	34800366
Pubmed	Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.	ACSL4 MARCHF5 PSMC5	8.99e-04	71	92	3	23503661
Pubmed	Regulation of HIV-1 transcription by protein phosphatase 1.	PPP2R2B PPP2R2C	9.17e-04	17	92	2	17266553
Pubmed	[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].	PPP2R2B PPP2R2C	9.17e-04	17	92	2	21351466
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP9X USP9Y	9.17e-04	17	92	2	23287719
Pubmed	Identification of casein kinase Ialpha interacting protein partners.	AP3B1 KPNB1	9.17e-04	17	92	2	12062430
Pubmed	Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7.	ACSL3 ACSL4	9.17e-04	17	92	2	14741744
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF15 PRAMEF11	9.17e-04	17	92	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF15 PRAMEF11	9.17e-04	17	92	2	37781892
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	ATP6V0C CGREF1 PSMC5 DMXL1 KPNB1	9.51e-04	283	92	5	18854154
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PKMYT1 DHX16 TLK2 KLHL2 URB1 PPP2R2D CARMIL1 DHX38 KPNB1 PTCD3	9.63e-04	1155	92	10	20360068
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	AP3B2 TNK2 OCLN AP3B1 DMXL1	9.81e-04	285	92	5	34369648
Cytoband	1p36.21	PRAMEF25 PRAMEF9 PRAMEF15 PRAMEF11	8.22e-06	63	92	4	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	PRAMEF25 PRAMEF9 PRAMEF15 AURKAIP1 ARHGEF16 PRAMEF27 PRAMEF11	4.52e-04	681	92	7	chr1p36
GeneFamily	PRAME family	PRAMEF25 PRAMEF9 PRAMEF15 PRAMEF27 PRAMEF11	1.76e-08	24	63	5	686
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R2B PPP2R2C PPP2R2D	1.78e-05	15	63	3	696
GeneFamily	ATP binding cassette subfamily A	ABCA3 ABCA13	1.06e-03	14	63	2	805
GeneFamily	DEAH-box helicases	DHX16 DHX38	1.39e-03	16	63	2	500
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF26 DNMBP ARHGEF16	1.58e-03	66	63	3	722
GeneFamily	WD repeat domain containing	PPP2R2B PPP2R2C PPP2R2D NBEAL2 DMXL1	2.18e-03	262	63	5	362
GeneFamily	Olfactory receptors, family 13	OR13D1 OR13F1	2.88e-03	23	63	2	162
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PKMYT1 SACS CASP2 OCLN	3.65e-03	181	63	4	694
GeneFamily	Acyl-CoA synthetase family	ACSL3 ACSL4	3.68e-03	26	63	2	40
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL3 PPP2R2B ABCA13 CAPN6 NIPSNAP2 MFSD4A	2.52e-06	189	91	6	e127e3be626bc513e151d41812f0b7adb89d5da6
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL3 PPP2R2B ABCA13 CAPN6 NIPSNAP2 MFSD4A	2.52e-06	189	91	6	ff637ae0afdb1fdc67451be7e1e4fe575fbcfff4
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ABCA13 NIPSNAP2 MFSD4A OCLN SLC4A11	2.59e-06	190	91	6	68ba1934b2b3f0cec8efd229fe1db6e8be8a26b0
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ABCA13 NIPSNAP2 MFSD4A OCLN SLC4A11	2.59e-06	190	91	6	010d7d13a3c16e614c36720ef690a505b9f3f7aa
ToppCell	Mesenchymal_cells-Fibro/Chondro_p.\|World / Lineage and Cell class	SERPINE2 CGREF1 CAPN6 PROSER2 SLC1A1 SLC1A4	3.10e-06	196	91	6	ddc168849e0e97005a111be004463bb72d433853
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFXN5 SERPINE2 NBEAL2 CARMIL1 FAM227A	9.50e-06	138	91	5	6b83c434895d82eaf3c222eef27acec76f9c0a77
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PPP2R2B ABCA13 NEB USP9Y USH2A	2.06e-05	162	91	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TGFBI ATP6V0C CAPN6 SLC1A4 PTCD3	2.60e-05	170	91	5	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	facs-BAT-Fat-24m-Myeloid-granulocyte\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI KLHL2 SFXN5 SLC2A6 GSR	2.60e-05	170	91	5	53916d85f0d6c7e5ef3d900d6ead946f75e32567
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SETMAR SACS CAPN6 PROSER2 GFPT1	2.98e-05	175	91	5	a5db428b078938627e61b7e944c1e0c1d61ac2da
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SETMAR SACS CAPN6 PROSER2 GFPT1	2.98e-05	175	91	5	8b498eea1ec1c1f27b171025c3d08adf3687bafc
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	URB1 ABCA13 MFSD4A PLCG2 SLC4A11	3.32e-05	179	91	5	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	NBEAL2 MFSD4A ARHGEF26 SLC1A1 TMEM139	3.32e-05	179	91	5	d5763912a4ce7188535675e338799b856edb9dda
ToppCell	COVID-19-lung-AT1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ABCA3 NBEAL2 OCLN ARHGEF26 SLC1A1	3.69e-05	183	91	5	7b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ABCA13 MFSD4A OCLN SLC4A11	3.89e-05	185	91	5	af86e75096c1812ae27a78405355957ee8043d84
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL3 SFXN5 SERPINE2 ARHGEF26 SLC1A4	3.99e-05	186	91	5	ac7a84b11b4550c4ac01eab370dc8ab88e4fb72b
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP2R2B ABCA13 CAPN6 NIPSNAP2 MFSD4A	4.20e-05	188	91	5	d2d2b6c49448da24f457cedcd213f68841834a99
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ABCA13 MFSD4A OCLN SLC4A11	4.20e-05	188	91	5	14e120b20e76baa07b6510a94f0c2dcdfdd52357
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ABCA13 MFSD4A OCLN SLC4A11	4.31e-05	189	91	5	443359d90fafae0c1de6bdcce9e8c95df6ea4de8
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KLHL2 SACS DNMBP SLC1A4 DMXL1	4.41e-05	190	91	5	ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ABCA13 NIPSNAP2 MFSD4A OCLN	4.41e-05	190	91	5	c247562df3e1aa3173c9f01a74d5831f0764a1b2
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ABCA13 NIPSNAP2 MFSD4A OCLN	4.41e-05	190	91	5	5cea8298c8336c136ba009630c9e48d4bc832cb2
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ABCA13 NIPSNAP2 MFSD4A OCLN	4.53e-05	191	91	5	5a5b5402a077b3189ca156f2bac5f47ad780aebf
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL3 SFXN5 SERPINE2 ARHGEF26 SLC1A4	4.53e-05	191	91	5	fd345837bfc40d85256b9a7e4fd3343bcbfe0ae5
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL3 SFXN5 SERPINE2 ARHGEF26 SLC1A4	4.64e-05	192	91	5	d2161842a38146261847fc9061ba9322e0f087e0
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL3 SFXN5 SERPINE2 ARHGEF26 SLC1A4	4.64e-05	192	91	5	261211a86e6f63b09c2ddce1d2d9257d311f1770
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ABCA13 NIPSNAP2 MFSD4A OCLN	4.64e-05	192	91	5	e19e3e8edcc08e4a67873bfb6e46489ca6c8756a
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ABCA13 NIPSNAP2 MFSD4A OCLN	4.64e-05	192	91	5	61c2caf6c838132ed5faa8791c288f2149eba2c8
ToppCell	AT1_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	NBEAL2 CAPN6 ARHGEF26 SLC1A1 TMEM139	4.64e-05	192	91	5	0444f9e9cef7403e220e862b5a787443d3f5c9ac
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP2R2B ABCA13 CAPN6 NIPSNAP2 MFSD4A	4.76e-05	193	91	5	b397c14ac1e34c6be3f25d4417d200bc518d3048
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP2R2B ABCA13 CAPN6 NIPSNAP2 MFSD4A	4.76e-05	193	91	5	241a60d1f0d5832638fb3e1e4b7afa7387ea3c75
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL4 ABCA13 CAPN6 NIPSNAP2 MFSD4A	4.76e-05	193	91	5	fa8bcf2a5ab7b08fae98a1466a936995142b4309
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 TOGARAM2 FAM227A DLEC1 PLCG2	4.87e-05	194	91	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	Mesenchymal_cells-Fibro/Chondro_p.\|Mesenchymal_cells / Lineage and Cell class	CGREF1 CAPN6 PROSER2 SLC1A1 SLC1A4	4.99e-05	195	91	5	b95a631d54c6cf85e48e1e638703206aaaebc073
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NBEAL2 OCLN ARHGEF26 SLC1A1 TMEM139	4.99e-05	195	91	5	68f4cc84b5ae7f4159b780c78e4b66c94211779a
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZYG11A KLHL2 LRRC20 OCLN SLC1A4	4.99e-05	195	91	5	1e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NBEAL2 OCLN ARHGEF26 SLC1A1 TMEM139	4.99e-05	195	91	5	2a1863f4b9fe73c30b0b1acf9b12fc98ef65040f
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NBEAL2 OCLN ARHGEF26 SLC1A1 TMEM139	5.12e-05	196	91	5	eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar-AT1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA3 OCLN ARHGEF26 SLC1A1 TMEM139	5.37e-05	198	91	5	54228dd9a50616d2022712d162a419ed0327cabd
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ACSL3 PPP2R2B NIPSNAP2 PLCG2 ARHGEF26	5.37e-05	198	91	5	81c4c5377d0901ee9594424f08b0e4101686c850
ToppCell	Epithelial_cells-AT1-AT2_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	NBEAL2 ARHGEF26 MINDY2 SLC1A1 TMEM139	5.37e-05	198	91	5	fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCell	Biopsy_Other_PF-Epithelial-Transitional_AT2\|Biopsy_Other_PF / Sample group, Lineage and Cell type	ABCA3 OCLN ARHGEF26 SLC1A1 TMEM139	5.63e-05	200	91	5	1ba6327851aa61e9a1f1fe1671bc27929d93ac74
Drug	Niridazole [61-57-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A	PPP2R2B SERPINE2 BTBD7 CASP2 PLCG2 NEB AP3B1 ARHGEF16	1.06e-06	197	89	8	5682_DN
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	PPP2R2B PPP2R2C PPP2R2D	4.98e-06	12	85	3	DOID:1441 (implicated_via_orthology)
Disease	non-syndromic X-linked intellectual disability 63 (implicated_via_orthology)	ACSL3 ACSL4	8.20e-06	2	85	2	DOID:0112050 (implicated_via_orthology)
Disease	glycocholenate sulfate measurement	ADCK5 DNMBP	1.22e-04	6	85	2	EFO_0800276
Disease	episodic ataxia type 6 (implicated_via_orthology)	SLC1A1 SLC1A4	1.22e-04	6	85	2	DOID:0050994 (implicated_via_orthology)
Disease	Sjogren-Larsson syndrome (implicated_via_orthology)	ACSL3 ACSL4	1.22e-04	6	85	2	DOID:14501 (implicated_via_orthology)
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	ACSL3 ACSL4	2.91e-04	9	85	2	DOID:0050776 (implicated_via_orthology)
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B2 DNMBP	4.44e-04	11	85	2	EFO_0021862
Disease	Pathological accumulation of air in tissues	PPP2R2C ABCA3	5.31e-04	12	85	2	C0013990
Disease	neutrophil collagenase measurement	ABCA13 DNMBP	9.59e-04	16	85	2	EFO_0008248
Disease	stem Cell Factor measurement	PPP2R2C SERPINE2 PLCG2	9.67e-04	67	85	3	EFO_0008291
Disease	epilepsy (implicated_via_orthology)	ATP6V0C SLC1A1 SLC1A4 UNC13A	1.28e-03	163	85	4	DOID:1826 (implicated_via_orthology)
Disease	obsessive-compulsive disorder, autism spectrum disorder	LRRC20 DLEC1	1.36e-03	19	85	2	EFO_0003756, EFO_0004242
Disease	progression free survival, ovarian serous carcinoma	ABCA13 SLC1A1	1.82e-03	22	85	2	EFO_0004920, EFO_1001516
Disease	alanine measurement	ACSL3 SLC1A4 SCAF4	1.99e-03	86	85	3	EFO_0009765
Disease	apolipoprotein L1 measurement	CYP11B2 DHX38	2.36e-03	25	85	2	EFO_0021854
Disease	Brain Diseases	SCO1 SLC1A1	2.36e-03	25	85	2	C0006111
Disease	macular telangiectasia type 2	NIPSNAP2 SLC1A4	2.55e-03	26	85	2	EFO_1002009
Disease	mean platelet volume	PITPNM2 ACSL3 ACSL4 LRRC66 SERPINE2 CARMIL1 INTS4 PLCG2 PROSER2	2.67e-03	1020	85	9	EFO_0004584
Disease	Encephalopathies	SCO1 SLC1A1	2.75e-03	27	85	2	C0085584

Protein segments in the cluster

Peptide	Gene	Start	Entry
ILPNKVDPLVSLMMV	PSMC5	126	P62195
LVMNTMEKTIVLPPL	UNC13A	1381	Q9UPW8
RVLTPPMGTVMDVLK	TGFBI	496	Q15582
LKPTLMAAVPEIMDR	ACSL4	366	O60488
KMEVINLTTLPMIPV	FAM227A	6	F5H4B4
TTLRVPVLRPMDLMV	PPP2R2B	146	Q00005
TSLQVPVLKPMDLMV	PPP2R2C	146	Q9Y2T4
PVLKPMDLMVEVSPR	PPP2R2C	151	Q9Y2T4
SMLPLLLKDELLMPS	ALG6	376	Q9Y672
RLPVMTMIPDVDCLL	GSR	316	P00390
ILPMQRVTRLPLLMD	ARHGEF16	421	Q5VV41
LMVTIMRIPAVKLEE	ABCA3	1226	Q99758
VLKPLLEMSGTLVML	ABCA13	2491	Q86UQ4
TALRVPILKPMDLMV	PPP2R2D	156	Q66LE6
PILKPMDLMVEASPR	PPP2R2D	161	Q66LE6
KPVQRVMRYPLLLME	DNMBP	921	Q6XZF7
VMAVLRELPRPMLLV	ADCK5	466	Q3MIX3
ILPMQRVTRLPLLMD	ARHGEF26	576	Q96DR7
MLPLTMTVLILLLLP	CGREF1	1	Q99674
AELPVDPMLSKMILA	DHX16	816	O60231
PMLALEVLSKMPKVI	DMXL1	1871	Q9Y485
PLLDTMRPDSLLKMT	ATG2A	416	Q2TAZ0
VLTPPMKMVTELAPL	TNK2	196	Q07912
SIRVPIIVPIMMLAI	AP3B1	141	O00203
SIRVPIIVPIMMLAI	AP3B2	136	Q13367
VPLIQEMESRIMIPL	NIPSNAP2	266	O75323
EMESRIMIPLKTSPL	NIPSNAP2	271	O75323
LDLMPRLMTSKPAEV	INTS4	781	Q96HW7
PPGVIRILSMLIIVM	OCLN	61	Q16625
ILMLMARDKHPPELQ	PTCD3	531	Q96EY7
VMVPKMLVDLVSPRK	OR10A7	76	Q8NGE5
RPVAPKEMERMVSII	PBX2	201	P40425
LPVPMAVLMLLSKER	MFSD4A	231	Q8N468
MPTMASVKLSALRPI	DPY19L1	556	Q2PZI1
MKMSIRTPPRLLELA	PRAMEF15	1	P0DUQ1
LPTIPVMLILGKMIR	MARCHF5	146	Q9NX47
MSIMVPKRVQVILPK	SERPINE2	281	P07093
MPPESQRKILMTLTV	PLCG2	1051	P16885
RVIAPPLIKFDMLMS	LRRC20	161	Q8TCA0
LMANVLLLVPPLMKP	OR51A2	276	Q8NGJ7
MIIKEYRIPLPMTVE	PITPNM2	1	Q9BZ72
RKKALESVPVMMLPD	NIM1K	396	Q8IY84
EAPVLIMILLLSFMP	SLC2A6	201	Q9UGQ3
LIRTPMEMRYIPLKV	PIGU	126	Q9H490
LITILPMMIIALEFP	LRRC66	231	Q68CR7
LQMVPALIAKMVPTI	RGR	246	P47804
PVIKPIMLPLLRTMS	CEFIP	866	Q711Q0
RVVLPIEAPIRMMIT	MT-CO2	141	P00403
IPVPRLLIMKDMVRR	BTBD7	646	Q9P203
VIQAMPTLIELMKDP	KPNB1	406	Q14974
LSPVRIMKKVSMEPS	CARMIL1	121	Q5VZK9
PRMVCVMLPEDVEKL	CYP11B2	86	P19099
PVQLRELTLDMPKMS	CAPN6	491	Q9Y6Q1
MPPALLKTVRMQEHL	DLEC1	1151	Q9Y238
DMKPPISRAKMILIT	SCAF4	16	O95104
MAMLVLVPGRVMRPL	SCO1	1	O75880
PLPSAVLQIMEKMPL	SACS	871	Q9NZJ4
EKLPKMRLPTRSDMI	CASP2	351	P42575
RMLKLIILPLIISSM	SLC1A1	61	P43005
MLKLIVPTIMLLPLT	MT-ND4	1	P03905
PPMLIIFMSERKSIS	OR13D1	111	Q8NGV5
QLIMLVISVLLLPMP	OR13F1	196	Q8NGS4
VISVLLLPMPMLLIC	OR13F1	201	Q8NGS4
TIMLVVSILLLPIPM	OR2K2	196	Q8NGT1
VKLPPMMEIITAEQL	MINDY2	281	Q8NBR6
VVPPILLDVKSRMML	USH2A	2536	O75445
RVLMKLMPPDSTTIE	USP9X	1041	Q93008
MIAMIPIRYILLPRI	SLC4A11	846	Q8NBS3
AKMIPLLRESLHPML	TOGARAM2	831	Q6ZUX3
GPLALVDKLMPVIMI	GFPT1	596	Q06210
VPTPLVMAQKISERM	PROSER2	191	Q86WR7
VRPPDCIKRSLLEMM	NBEAL2	1486	Q6ZNJ1
MKMSIRTPPRLLELA	PRAMEF25	1	A6NGN4
AALAPSMMKIRIIAP	POTEJ	981	P0CG39
LMIPVRIDSMVPKLA	SETMAR	231	Q53H47
MKMSIRTPPRLLELA	PRAMEF27	1	A3QJZ7
MPLKSIAESRILPLM	WRN	1271	Q14191
FIPLPRLLAMVMVTT	URB1	416	O60287
TEKVPMLEMTLPGLR	SULT1B1	76	O43704
LPTLMSVMLAKPRLD	TLK2	146	Q86UE8
EEMLVPRKMSVSPLE	AURKAIP1	61	Q9NWT8
KPTLMAAVPEIMDRI	ACSL3	376	O95573
MAFLMLVDPLIRKPD	TMEM9	106	Q9P0T7
VMRPEQIMKSIIPVV	ATP6V0C	46	P27449
ELRSVLVMMLEPDPK	PKMYT1	331	Q99640
LVMMLEPDPKLRATA	PKMYT1	336	Q99640
MLLRMLRMIILPLVV	SLC1A4	81	P43007
MKMSIRTPPRLLELA	PRAMEF9	1	P0DUQ2
DFLIPMLEMVPEKRA	SRPK2	661	P78362
MKMSIRIPPRLLELA	PRAMEF11	1	O60813
MVEFPLDPALSKMLI	DHX38	946	Q92620
IIEVRTTMPLEMPEK	SH2B2	256	O14492
ARVLMKLMPPDRTAV	USP9Y	1041	O00507
ITMMSRPPVLLEKVI	WLS	256	Q5T9L3
LPPIVMSMLEKTALL	SFXN5	266	Q8TD22
VTMPAILKLVAIGMR	ZYG11A	376	Q6WRX3
IMPKPIMVIPTLASL	ZNF438	436	Q7Z4V0
MVPMHLLGRLEKPLL	TMEM139	1	Q8IV31
RTRLRTPMNLPKLMV	KLHL2	296	O95198
MPDTPEIMLAKLNRI	NEB	3466	P20929