Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear receptor binding	PRAMEF33 HIF1A PRAMEF1 AR GTF2B MECR PRAMEF14 TAF7	1.60e-04	187	164	8	GO:0016922
GeneOntologyMolecularFunction	iron-responsive element binding	ACO1 IREB2	2.00e-04	3	164	2	GO:0030350
GeneOntologyMolecularFunction	aconitate hydratase activity	ACO1 IREB2	2.00e-04	3	164	2	GO:0003994
GeneOntologyMolecularFunction	insulin receptor substrate binding	JAK2 PIK3CA WDR6	2.30e-04	15	164	3	GO:0043560
Domain	Aconitase/IRP2	ACO1 IREB2	7.57e-05	2	163	2	IPR006249
Domain	Ser-Thr/Tyr_kinase_cat_dom	DDR1 AXL NEK7 JAK2 FGFR4 LYN PRKY	2.11e-04	138	163	7	IPR001245
Domain	AconitaseA/IPMdHydase_ssu_swvl	ACO1 IREB2	2.26e-04	3	163	2	IPR000573
Domain	Aconitase_C	ACO1 IREB2	2.26e-04	3	163	2	PF00694
Domain	-	ACO1 IREB2	2.26e-04	3	163	2	3.30.499.10
Domain	Acoase/IPM_deHydtase_lsu_aba	ACO1 IREB2	2.26e-04	3	163	2	IPR001030
Domain	-	ACO1 IREB2	2.26e-04	3	163	2	3.40.1060.10
Domain	-	ACO1 IREB2	2.26e-04	3	163	2	3.20.19.10
Domain	Acoase/IPM_deHydtase	ACO1 IREB2	2.26e-04	3	163	2	IPR015937
Domain	Acnase/IPM_dHydase_lsu_aba_1/3	ACO1 IREB2	2.26e-04	3	163	2	IPR015931
Domain	Aconitase/IPMdHydase_lsu_aba_2	ACO1 IREB2	2.26e-04	3	163	2	IPR015932
Domain	ACONITASE_1	ACO1 IREB2	2.26e-04	3	163	2	PS00450
Domain	Aconitase/3IPM_dehydase_swvl	ACO1 IREB2	2.26e-04	3	163	2	IPR015928
Domain	Aconitase	ACO1 IREB2	2.26e-04	3	163	2	PF00330
Domain	Aconitase_4Fe-4S_BS	ACO1 IREB2	2.26e-04	3	163	2	IPR018136
Domain	ACONITASE_2	ACO1 IREB2	2.26e-04	3	163	2	PS01244
Domain	Kinase-like_dom	DDR1 AXL NEK7 ACAD10 MAP3K6 RPS6KC1 JAK2 PIK3CA MTOR ALPK3 FGFR4 LYN MAP2K7 PRKY	2.93e-04	542	163	14	IPR011009
Domain	TF_T-box	TBX15 TBR1 TBX6	4.06e-04	17	163	3	IPR001699
Domain	TBOX	TBX15 TBR1 TBX6	4.06e-04	17	163	3	SM00425
Domain	TF_T-box_CS	TBX15 TBR1 TBX6	4.06e-04	17	163	3	IPR018186
Domain	-	TBX15 TBR1 TBX6	4.06e-04	17	163	3	2.60.40.820
Domain	TBOX_3	TBX15 TBR1 TBX6	4.06e-04	17	163	3	PS50252
Domain	T-box	TBX15 TBR1 TBX6	4.06e-04	17	163	3	PF00907
Domain	TBOX_1	TBX15 TBR1 TBX6	4.06e-04	17	163	3	PS01283
Domain	TBOX_2	TBX15 TBR1 TBX6	4.06e-04	17	163	3	PS01264
Domain	Terpenoid_cyclase/PrenylTrfase	CPAMD8 CD109 ASIC3	4.84e-04	18	163	3	IPR008930
Domain	Tyr_kinase_cat_dom	DDR1 AXL JAK2 FGFR4 LYN	1.04e-03	88	163	5	IPR020635
Domain	TyrKc	DDR1 AXL JAK2 FGFR4 LYN	1.04e-03	88	163	5	SM00219
Pathway	REACTOME_CDC42_GTPASE_CYCLE	STARD13 ARHGAP32 RASGRF2 DOCK11 ARHGAP10 PLEKHG3 PREX1	1.68e-05	94	122	7	MM15598
Pathway	REACTOME_RHO_GTPASE_CYCLE	STARD13 ARHGAP32 NCKAP1 DSG1 RASGRF2 DOCK11 ARHGAP10 SPTAN1 OCRL PIK3CA WDR6 PLEKHG3 FAM135A PREX1	2.61e-05	439	122	14	MM15595
Pathway	REACTOME_RHO_GTPASE_CYCLE	STARD13 ARHGAP32 NCKAP1 DSG1 RASGRF2 DOCK11 ARHGAP10 SPTAN1 OCRL PIK3CA WDR6 PLEKHG3 FAM135A PREX1	3.42e-05	450	122	14	M27078
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	STARD13 ARHGAP32 NCKAP1 DSG1 RASGRF2 DOCK11 ARHGAP10 AHCTF1 SPTAN1 OCRL AR PIK3CA WDR6 PLEKHG3 ZW10 FAM135A PREX1	4.26e-05	649	122	17	MM15690
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING	HIF1A VWF ITGA10 CASP9 LAMC1 ITGA2B JAK2 PIK3CA MTOR PHLPP1 FGFR4	6.18e-05	302	122	11	M39719
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY	HIF1A VWF ITGA10 CASP9 LAMC1 ITGA2B JAK2 PIK3CA MTOR PHLPP1 FGFR4	1.22e-04	326	122	11	MM15917
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K	JAK2 PIK3CA LYN	1.31e-04	12	122	3	M27905
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K	JAK2 PIK3CA LYN	1.31e-04	12	122	3	MM15623
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGAP32 NCKAP1 RASGRF2 DOCK11 ARHGAP10 PIK3CA PLEKHG3 PREX1	1.39e-04	175	122	8	MM15599
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	STARD13 ARHGAP32 NCKAP1 DSG1 RASGRF2 DOCK11 ARHGAP10 AHCTF1 SPTAN1 OCRL AR PIK3CA WDR6 PLEKHG3 ZW10 FAM135A PREX1	1.52e-04	720	122	17	M41838
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGAP32 NCKAP1 RASGRF2 DOCK11 ARHGAP10 PIK3CA PLEKHG3 PREX1	1.96e-04	184	122	8	M41809
Pathway	WP_MODULATION_OF_PI3KAKTMTOR_SIGNALING_BY_BIOACTIVE_SPHINGOLIPIDS	HIF1A PIK3CA MTOR	2.15e-04	14	122	3	M45553
Pathway	PID_IL5_PATHWAY	JAK2 PIK3CA LYN	2.15e-04	14	122	3	M135
Pathway	REACTOME_RHOJ_GTPASE_CYCLE	ARHGAP32 OCRL PREX1	3.26e-04	16	122	3	MM15605
Pathway	REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	VWF ITGA10 LYN	3.26e-04	16	122	3	M9450
Pathway	WP_TCA_CYCLE_AND_DEFICIENCY_OF_PYRUVATE_DEHYDROGENASE_COMPLEX_PDHC	ACO1 IDH3A SUCLG2	3.26e-04	16	122	3	M39489
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	JAK2 PIK3CA LYN	3.94e-04	17	122	3	MM15584
Pathway	REACTOME_CDC42_GTPASE_CYCLE	STARD13 ARHGAP32 RASGRF2 DOCK11 ARHGAP10 PLEKHG3 PREX1	3.95e-04	155	122	7	M41808
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	STARD13 DNAJC13 CCDC22 NCKAP1 DSG1 DHX40 AHCTF1 SPTAN1 NEK7 NOL10 FAM98A ACTL6A MCCC2 OCRL AGPS SUCLG2 BIRC6 GTF3C4 WDR47 WDR6 PLEKHG3 EIF2B5 INTS11 SNX27 SNRNP200	1.04e-08	1353	169	25	29467282
Pubmed	Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer.	AR PIK3CA MTOR	1.13e-07	3	169	3	26506516
Pubmed	The immune receptor Tim-3 mediates activation of PI3 kinase/mTOR and HIF-1 pathways in human myeloid leukaemia cells.	HIF1A PIK3CA MTOR	4.49e-07	4	169	3	25483439
Pubmed	Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice.	DOK2 ITGA2B LYN	4.49e-07	4	169	3	24385425
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	IPPK MXRA5 ANK1 DOCK11 TAS1R3 AGPS BIRC6 GSDMC RPS6KC1 JAK2 EBLN1 PITPNM3 TBR1 LYN SNRNP200	3.46e-06	736	169	15	29676528
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RAD52 DDR1 CPAMD8 HIF1A DNAJC13 FOLH1 ARHGAP10 TMPRSS6 FRMPD2 HECTD4 TMPRSS5 MCCC2 AR STT3A JAK2 KLHL9 PLEKHG3 LMLN ZFHX2 ZFHX3 SEMA6A PACRG	3.58e-06	1489	169	22	28611215
Pubmed	Putative tyrosine kinases expressed in K-562 human leukemia cells.	AXL FGFR4 LYN	3.89e-06	7	169	3	2247464
Pubmed	FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.	ACO1 IREB2 MTOR TBR1	6.28e-06	25	169	4	28069738
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	TBX15 SNHG12 SZT2 TAS1R3 CASP9 GBP3 PRAMEF1 RPS6KC1 GARIN4 GTF2B MECR ZNF684 MTOR PRAMEF14 INTS11 SNX27 IGSF21	1.24e-05	1031	169	17	16710414
Pubmed	Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.	JAK2 FGFR4 LYN	1.32e-05	10	169	3	12244095
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF33 PKD1L2 PRAMEF1 PRAMEF14	1.34e-05	30	169	4	38786026
Pubmed	Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.	HECTD4 ACAD10 PLCE1	1.81e-05	11	169	3	21642993
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	DSG1 DOCK11 STRBP SPTAN1 FAM98A ACAD10 RPS6KC1 WDR6 MIOS SNX27 TLN2	2.29e-05	475	169	11	31040226
Pubmed	A regulated RNA binding protein also possesses aconitase activity.	ACO1 IREB2	2.35e-05	2	169	2	1946430
Pubmed	Differential effects of inhibitors of the PI3K/mTOR pathway on the expansion and functionality of regulatory T cells.	PIK3CA MTOR	2.35e-05	2	169	2	27189717
Pubmed	AR imposes different effects on ZFHX3 transcription depending on androgen status in prostate cancer cells.	AR ZFHX3	2.35e-05	2	169	2	34953044
Pubmed	Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.	ACO1 IREB2	2.35e-05	2	169	2	14726953
Pubmed	Immunohistochemical analysis of the mechanistic target of rapamycin and hypoxia signalling pathways in basal cell carcinoma and trichoepithelioma.	HIF1A MTOR	2.35e-05	2	169	2	25181405
Pubmed	Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins.	ACO1 IREB2	2.35e-05	2	169	2	17200797
Pubmed	Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region.	HIF1A TMPRSS6	2.35e-05	2	169	2	22628316
Pubmed	In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.	ACO1 IREB2	2.35e-05	2	169	2	19533074
Pubmed	Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2.	ACO1 IREB2	2.35e-05	2	169	2	15831703
Pubmed	Prolonged androgen deprivation leads to downregulation of androgen receptor and prostate-specific membrane antigen in prostate cancer cells.	FOLH1 AR	2.35e-05	2	169	2	23041906
Pubmed	Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.	ACO1 IREB2	2.35e-05	2	169	2	25771171
Pubmed	Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.	ACO1 IREB2	2.35e-05	2	169	2	8262972
Pubmed	HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells.	HIF1A MTOR	2.35e-05	2	169	2	25349289
Pubmed	Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.	HIF1A MTOR	2.35e-05	2	169	2	12242281
Pubmed	Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.	ACO1 IREB2	2.35e-05	2	169	2	16503547
Pubmed	Self-association and ligand-induced conformational changes of iron regulatory proteins 1 and 2.	ACO1 IREB2	2.35e-05	2	169	2	15938636
Pubmed	Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma.	PIK3CA MTOR	2.35e-05	2	169	2	21372221
Pubmed	DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing HIF-1α Ubiquitination and Degradation.	DDR1 HIF1A	2.35e-05	2	169	2	39024501
Pubmed	PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer.	PIK3CA MTOR	2.35e-05	2	169	2	20479250
Pubmed	Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.	ACO1 IREB2	2.35e-05	2	169	2	2172968
Pubmed	[PI3K and mTOR pathway and molecular targeted agents].	PIK3CA MTOR	2.35e-05	2	169	2	26281684
Pubmed	Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.	HIF1A IDH3A	2.35e-05	2	169	2	25531325
Pubmed	Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved.	HIF1A ACO1	2.35e-05	2	169	2	21360641
Pubmed	Effect of Primary Letrozole Treatment on Tumor Expression of mTOR and HIF-1α and Relation to Clinical Response.	HIF1A MTOR	2.35e-05	2	169	2	26063890
Pubmed	Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor.	REL AR	2.35e-05	2	169	2	17011549
Pubmed	Structural insights of a PI3K/mTOR dual inhibitor with the morpholino-triazine scaffold.	PIK3CA MTOR	2.35e-05	2	169	2	26956874
Pubmed	Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes.	TRPC6 PLCE1	2.35e-05	2	169	2	25521631
Pubmed	Phosphorylated mTOR is associated to androgen receptor expression in early triple-negative breast cancer.	AR MTOR	2.35e-05	2	169	2	27350136
Pubmed	Muscle regulates mTOR dependent axonal local translation in motor neurons via CTRP3 secretion: implications for a neuromuscular disorder, spinal muscular atrophy.	MTOR C1QTNF3	2.35e-05	2	169	2	31615574
Pubmed	Asprosin promotes β-cell apoptosis by inhibiting the autophagy of β-cell via AMPK-mTOR pathway.	FBN1 MTOR	2.35e-05	2	169	2	32557691
Pubmed	Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels.	HIF1A AXL	2.35e-05	2	169	2	34266948
Pubmed	Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer.	HIF1A MTOR	2.35e-05	2	169	2	16341243
Pubmed	Ehrlichia Activation of Wnt-PI3K-mTOR Signaling Inhibits Autolysosome Generation and Autophagic Destruction by the Mononuclear Phagocyte.	PIK3CA MTOR	2.35e-05	2	169	2	28993455
Pubmed	Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1.	PIK3CA MTOR	2.35e-05	2	169	2	21071597
Pubmed	Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer.	PIK3CA MTOR	2.35e-05	2	169	2	25497009
Pubmed	Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia.	HIF1A SLC29A2	2.35e-05	2	169	2	19105964
Pubmed	Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues.	CLDN15 CLDN10	2.35e-05	2	169	2	35650657
Pubmed	SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation.	GPR17 SNX27	2.35e-05	2	169	2	27270750
Pubmed	Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC.	PIK3CA MTOR	2.35e-05	2	169	2	27507059
Pubmed	Crucial role of TRPC6 in maintaining the stability of HIF-1α in glioma cells under hypoxia.	HIF1A TRPC6	2.35e-05	2	169	2	26187851
Pubmed	HIF-1α-mediated LAMC1 overexpression is an unfavorable predictor of prognosis for glioma patients: evidence from pan-cancer analysis and validation experiments.	HIF1A LAMC1	2.35e-05	2	169	2	38678297
Pubmed	Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.	PIK3CA MTOR	2.35e-05	2	169	2	20857497
Pubmed	Modifying murine von Willebrand factor A1 domain for in vivo assessment of human platelet therapies.	VWF ITGA2B	2.35e-05	2	169	2	18084279
Pubmed	Brain oxygen tension controls the expansion of outer subventricular zone-like basal progenitors in the developing mouse brain.	HIF1A VWF	2.35e-05	2	169	2	26329599
Pubmed	Hypoxia: Turning vessels into vassals of cancer immunotolerance.	HIF1A MTOR	2.35e-05	2	169	2	32470491
Pubmed	Noninvasive measurement of androgen receptor signaling with a positron-emitting radiopharmaceutical that targets prostate-specific membrane antigen.	FOLH1 AR	2.35e-05	2	169	2	21606347
Pubmed	HIF-1α Activates Hypoxia-Induced MXRA5 Expression in the Progression of Ovarian Cancer.	HIF1A MXRA5	2.35e-05	2	169	2	39462449
Pubmed	Excess capacity of the iron regulatory protein system.	ACO1 IREB2	2.35e-05	2	169	2	17604281
Pubmed	Phosphatidylinositol-3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinase.	PIK3CA LYN	2.35e-05	2	169	2	22777522
Pubmed	Pro-Apoptotic Activity of Ruxolitinib Alone and in Combination with Hydroxyurea, Busulphan, and PI3K/mTOR Inhibitors in JAK2-Positive Human Cell Lines.	JAK2 MTOR	2.35e-05	2	169	2	25931349
Pubmed	Mutational analysis of PIK3CA, JAK2, BRAF, FOXL2, IDH1, AKT1 and EZH2 oncogenes in sarcomas.	JAK2 PIK3CA	2.35e-05	2	169	2	22779686
Pubmed	Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo.	ACO1 IREB2	2.35e-05	2	169	2	15604406
Pubmed	The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation.	HIF1A MTOR	2.35e-05	2	169	2	23872956
Pubmed	Subcellular localization of iron regulatory proteins to Golgi and ER membranes.	ACO1 IREB2	2.35e-05	2	169	2	16144863
Pubmed	Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism.	ACO1 IREB2	2.35e-05	2	169	2	15866737
Pubmed	Effect of HIF1α on the TRPC6 channel of glomerular podocytes under chronic hypoxia.	HIF1A TRPC6	2.35e-05	2	169	2	33450580
Pubmed	Aerobic Glycolysis Induced by mTOR/HIF-1α Promotes Early Brain Injury After Subarachnoid Hemorrhage via Activating M1 Microglia.	HIF1A MTOR	2.35e-05	2	169	2	36385451
Pubmed	Trihydrophobin 1 attenuates androgen signal transduction through promoting androgen receptor degradation.	NELFCD AR	2.35e-05	2	169	2	20069563
Pubmed	Antitumor effects of low-dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF-1α-expressing gastric cancer cells.	HIF1A MTOR	2.35e-05	2	169	2	33773069
Pubmed	mTOR regulates proteasomal degradation and Dp1/E2F1- mediated transcription of KPNA2 in lung cancer cells.	MTOR KPNA2	2.35e-05	2	169	2	27009856
Pubmed	Strong Expression of Hypoxia-Inducible Factor-1α (HIF-1α) Is Associated with Axl Expression and Features of Aggressive Tumors in African Breast Cancer.	HIF1A AXL	2.35e-05	2	169	2	26760782
Pubmed	mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells.	MTOR PHLPP1	2.35e-05	2	169	2	21177869
Pubmed	Helicobacter pylori promotes eukaryotic protein translation by activating phosphatidylinositol 3 kinase/mTOR.	PIK3CA MTOR	2.35e-05	2	169	2	25194338
Pubmed	Iron regulatory proteins secure mitochondrial iron sufficiency and function.	ACO1 IREB2	2.35e-05	2	169	2	20674864
Pubmed	Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13.	NELFCD CTSZ	2.35e-05	2	169	2	11030415
Pubmed	Novel targeting of phosphatidylinositol 3-kinase and mammalian target of rapamycin in renal cell carcinoma.	PIK3CA MTOR	2.35e-05	2	169	2	23867512
Pubmed	The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia.	HIF1A ACO1	2.35e-05	2	169	2	30415773
Pubmed	Dual inhibition of PI3K and mTOR signaling pathways decreases human pancreatic neuroendocrine tumor metastatic progression.	PIK3CA MTOR	2.35e-05	2	169	2	24263107
Pubmed	Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling.	HIF1A MTOR	2.35e-05	2	169	2	27314664
Pubmed	Lowe syndrome patient cells display mTOR- and RhoGTPase-dependent phenotypes alleviated by rapamycin and statins.	OCRL MTOR	2.35e-05	2	169	2	32391547
Pubmed	Gene Expression Studies to Identify Significant Genes in AR, MTOR, MAPK Pathways and their Overlapping Regulatory Role in Prostate Cancer.	AR MTOR	2.35e-05	2	169	2	31136301
Pubmed	A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway.	HIF1A MTOR	2.35e-05	2	169	2	33236147
Pubmed	The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.	ACO1 IREB2	2.35e-05	2	169	2	8041788
Pubmed	Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.	REL JAK2	2.35e-05	2	169	2	12478664
Pubmed	mTOR signaling disruption from myeloid-derived suppressive cells protects against immune-mediated hepatic injury through the HIF1α-dependent glycolytic pathway.	HIF1A MTOR	2.35e-05	2	169	2	27462101
Pubmed	[Change of HIF-1alpha protein expression in the placenta bed and concentration of vWF in maternal peripheral blood of pre-eclampsia].	HIF1A VWF	2.35e-05	2	169	2	20197612
Pubmed	Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.	ACO1 IREB2	2.35e-05	2	169	2	16283625
Pubmed	NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population.	NELFCD CTSZ	2.35e-05	2	169	2	29795304
Pubmed	Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis.	ACO1 IREB2	2.35e-05	2	169	2	38301068
Pubmed	Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis.	VWF ITGA2B	2.35e-05	2	169	2	1737795
Pubmed	A Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences.	HECTD4 ACAD10	2.35e-05	2	169	2	34828409
Pubmed	Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation.	HIF1A MTOR	2.35e-05	2	169	2	28747716
Pubmed	Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo.	ACO1 IREB2	2.35e-05	2	169	2	15208438
Pubmed	In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC.	PIK3CA MTOR	2.35e-05	2	169	2	27765909
Pubmed	Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.	ACO1 IREB2	2.35e-05	2	169	2	21566147
Pubmed	Phosphorylation of ankyrin down-regulates its cooperative interaction with spectrin and protein 3.	ANK1 SPTAN1	2.35e-05	2	169	2	2970468
Pubmed	Impact of Androgen Receptor Activity on Prostate-Specific Membrane Antigen Expression in Prostate Cancer Cells.	FOLH1 AR	2.35e-05	2	169	2	35162969
Cytoband	1p36.21	PRAMEF33 CASP9 PRAMEF1 PRAMEF14	8.91e-05	63	169	4	1p36.21
GeneFamily	T-boxes	TBX15 TBR1 TBX6	1.76e-04	18	112	3	766
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 FOLH1 FAT3 GRID1 CPS1 PKD1L2 TLN2 PLCE1	5.35e-07	184	169	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 FOLH1 FAT3 GRID1 CPS1 PKD1L2 TLN2 PLCE1	5.35e-07	184	169	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 FOLH1 FAT3 GRID1 CPS1 PKD1L2 TLN2 PLCE1	5.35e-07	184	169	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	DOCK11 ARHGAP10 AOAH CD109 REL LYN IGSF21 PREX1	7.09e-07	191	169	8	3b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCell	facs-Spleen-nan-18m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 AOAH DOK2 ZFHX3 ADAMTS14 PACRG PREX1	2.36e-06	157	169	7	a84377028c661f8f3ecae0f6082abdd859faf0c8
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell-SMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MUSTN1 TBX15 AXL PLEKHG3 ZFHX3 ADAMTS14 PLCE1	2.47e-06	158	169	7	5b3d30f92b619f14a7b48502170000fa5783358a
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MUSTN1 TBX15 AXL PLEKHG3 ZFHX3 ADAMTS14 PLCE1	2.47e-06	158	169	7	08806240228c5b780f5aef92ce2c278ae4d797cc
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MUSTN1 TBX15 AXL PLEKHG3 ZFHX3 ADAMTS14 PLCE1	2.47e-06	158	169	7	496b6988f7b3439968351840ae22f56ffa1643f1
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell-SMC\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MUSTN1 TBX15 AXL PLEKHG3 ZFHX3 ADAMTS14 PLCE1	3.16e-06	164	169	7	9eed945e9b0c1ee5fc62724ac2bbbed4267b0678
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MUSTN1 TBX15 AXL PLEKHG3 ZFHX3 ADAMTS14 PLCE1	3.16e-06	164	169	7	f510f20e37e31b486cdd0e3f597ce4ff00877c5d
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MUSTN1 TBX15 AXL PLEKHG3 ZFHX3 ADAMTS14 PLCE1	3.16e-06	164	169	7	5c932a462cbf81d029c8d11ec3aea3191529527b
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP10 IREB2 GTF2B MTOR ZFHX2 ADAMTS14	4.66e-06	113	169	6	357bc20edc5bc14eab8262d52260ed1686e9dc54
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP10 IREB2 GTF2B MTOR ZFHX2 ADAMTS14	4.66e-06	113	169	6	91e73e3b93be242fef0f14eddd8085a1f1c730ef
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF RASGRF2 SZT2 KIAA0586 SIT1 JAK2 CXCR6	5.42e-06	178	169	7	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZNF536 GPR17 RASGRF2 HS6ST2 PPM1E ST6GALNAC5 PREX1	6.04e-06	181	169	7	fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MUSTN1 ZNF536 ANK1 DOCK11 HS6ST2 ALPK3 PLCE1	6.73e-06	184	169	7	7d41784eac0935e77d6bc701f20c693adf998730
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZNF536 GPR17 RASGRF2 HS6ST2 PPM1E ST6GALNAC5 PREX1	6.97e-06	185	169	7	56c7a0dbf141728ac76b8c90af197719942ca67c
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZNF536 GPR17 RASGRF2 HS6ST2 PPM1E ST6GALNAC5 PREX1	6.97e-06	185	169	7	a8946379fc066903fe8f4bc9cbf693b7b424a0cd
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANK1 HS6ST2 ALPK3 TLN2 C1QTNF3 SEMA6A FGFR4	7.48e-06	187	169	7	69b47f00598d647e2a99427ebddf42c339428e47
ToppCell	facs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 ANK1 HS6ST2 TMPRSS5 C1QTNF3 FGFR4 IGSF21	7.75e-06	188	169	7	794fc1d9a726945c42f7eac221eed938309b47a9
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTS3 ARHGAP10 GBP3 JAK2 FBN1 C1R SEMA6A	8.30e-06	190	169	7	0fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK1 RASGRF2 DOCK11 TRPC6 ST6GALNAC5 SEMA6A NPAS1	8.89e-06	192	169	7	dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX15 AXL TMPRSS6 CD109 LAMC1 ITGA2B FBN1	9.19e-06	193	169	7	316ebdf15f75d88c348f909b643fcd315364ca84
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK1 RASGRF2 DOCK11 TRPC6 ST6GALNAC5 SEMA6A NPAS1	9.19e-06	193	169	7	3ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCell	droplet-Fat-Scat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX15 AXL TMPRSS6 CD109 LAMC1 ITGA2B FBN1	9.19e-06	193	169	7	8dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX15 AXL TMPRSS6 CD109 LAMC1 ITGA2B FBN1	9.19e-06	193	169	7	1afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUSTN1 TBX15 AXL TRPC6 ZFHX3 ADAMTS14 PLCE1	9.51e-06	194	169	7	bf34737ae2dc218f890fbb9201c308b324415749
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUSTN1 TBX15 AXL TMPRSS6 CLDN10 C1QTNF3 FGFR4	9.51e-06	194	169	7	c2990d6eda3954dc01913bf3910df79f06e0010a
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUSTN1 TBX15 AXL TMPRSS6 CLDN10 C1QTNF3 FGFR4	9.51e-06	194	169	7	0e315c63407fa00643722a7d6138b1502f79b10d
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUSTN1 TBX15 AXL TMPRSS6 CLDN10 C1QTNF3 FGFR4	9.51e-06	194	169	7	588c45dafa00547b2506e298a2434b1b5e15560d
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUSTN1 TBX15 AXL TRPC6 ZFHX3 ADAMTS14 PLCE1	9.51e-06	194	169	7	b35e33439b6d3b5d69147e617224d2c8fd056223
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUSTN1 TBX15 AXL TRPC6 ZFHX3 ADAMTS14 PLCE1	9.51e-06	194	169	7	4ebed7a6731b88c8359860072cbeba355a7e90ac
ToppCell	IIH-mono3-\|IIH / Condition, Cell_class and T cell subcluster	HIF1A AXL REL ALPK3 TLN2 IGSF21 CTSZ	9.83e-06	195	169	7	28a858b04a7b413916c07a8d880f5ea02e985461
ToppCell	IIH-mono3\|IIH / Condition, Cell_class and T cell subcluster	HIF1A AXL REL ALPK3 TLN2 IGSF21 CTSZ	9.83e-06	195	169	7	c6dd5af582d257be64b718e30f60220c1bf1738a
ToppCell	Mesenchymal_cells-Myofibroblasts\|World / Lineage and Cell class	ANK1 HS6ST2 TMPRSS6 TLN2 C1QTNF3 SEMA6A FGFR4	1.02e-05	196	169	7	2c0f429ae18c2df05c33ddf58dcc2c94b819b9a1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 DOCK11 AXL AOAH LYN IGSF21 PREX1	1.02e-05	196	169	7	cbc727b55b6433a701b1a331028a49960fcee6ee
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NOG AXL FAT3 ITGA10 SUCLG2 C1R TLN2	1.05e-05	197	169	7	d7cef7881abd807a679432766ced609a6efd1067
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NOG AXL FAT3 ITGA10 SUCLG2 C1R TLN2	1.05e-05	197	169	7	20a5958512bdb99daeb8f4d244df53e4f048f879
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF536 LAMC1 PKD1L2 GARIN4 ST6GALNAC5 C1R FGFR4	1.09e-05	198	169	7	7f728ca6d5317890c6fcde3ce6c10c0970d49a05
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF536 ANK1 RASGRF2 DOCK11 TRPC6 SEMA6A LYN	1.16e-05	200	169	7	f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF536 ANK1 RASGRF2 DOCK11 TRPC6 SEMA6A LYN	1.16e-05	200	169	7	70a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF536 ANK1 RASGRF2 DOCK11 TRPC6 PLCE1 NPAS1	1.16e-05	200	169	7	107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF536 ANK1 RASGRF2 DOCK11 TRPC6 SEMA6A LYN	1.16e-05	200	169	7	1639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	VWF NCKAP1 SPTAN1 CD109 CLDN10 FBN1 FAM135A	1.16e-05	200	169	7	77ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell	Lung_Parenchyma-Control-Hematopoietic\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IPPK ANK1 ACRBP ITGA2B GFOD2 PHLPP1	2.53e-05	152	169	6	71d5061aee7f744b2db3c3892d15c6919d07c0be
ToppCell	Lung_Parenchyma-Control-Hematopoietic-RBC-RBC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IPPK ANK1 ACRBP ITGA2B GFOD2 PHLPP1	2.53e-05	152	169	6	27f25c1e22a81fbdd6c39ca47eeb310939211362
ToppCell	Lung_Parenchyma-Control-Hematopoietic-RBC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IPPK ANK1 ACRBP ITGA2B GFOD2 PHLPP1	2.53e-05	152	169	6	df87b8333e3f54fab0d8b1e8690f1a36bcb7e9e3
ToppCell	Lung_Parenchyma-Control-Hematopoietic-RBC-RBC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IPPK ANK1 ACRBP ITGA2B GFOD2 PHLPP1	2.53e-05	152	169	6	98cdcf18daeb728974ab133b365b7352b08558a8
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Erythrocytes\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	IPPK ANK1 ACRBP ITGA2B GFOD2 PHLPP1	2.53e-05	152	169	6	bf07aafe2f36eda3a9cda93083ca7a081498e36e
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AXL PPM1E FAM98A SLC29A2 PLEKHG3 PLCE1	4.29e-05	167	169	6	784776d1fcc098f84d3c2eca58fa56cb9428f434
ToppCell	Tuft-tuft-1\|World / Class top	MUSTN1 ANK1 RASGRF2 EML6 FAM98A TBX6	4.44e-05	168	169	6	8ddc2ec483ed2c6c0fb2ae521c6861ceb6d32e34
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IPPK RAD52 ADAMTS3 ACAD10 AR LMLN	4.74e-05	170	169	6	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP32 AXL FAT3 TRPC6 HECTD4 GALNT9	4.74e-05	170	169	6	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	wk_20-22-Mesenchymal-Chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MXRA5 ITGA10 TMPRSS5 AR ZFHX3 IGSF21	4.90e-05	171	169	6	d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OR9A4 ANK1 AXL TMPRSS6 FBN1 TBR1	5.39e-05	174	169	6	68a6ed81e7e1f95b61f7ee20403980fa3a8db4d0
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TBX15 NOG AXL TMPRSS6 GRID1 FBN1	5.39e-05	174	169	6	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMTR1 FAM151A MTOR PITPNM3 ZFHX2 FAM135A	5.39e-05	174	169	6	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF TMPRSS6 TRPC6 NEK7 CLDN10 PXYLP1	5.57e-05	175	169	6	0992de1c7bffcb6890584357a7a0a8955927da6c
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TAS1R3 TMPRSS6 FAT3 ZFHX2 ZFHX3 FGFR4	6.12e-05	178	169	6	f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF536 ANK1 DOCK11 TRPC6 ALPK3 PLCE1	6.71e-05	181	169	6	af92b8b7f455210dab502ef6964f3a0162180759
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZNF536 GPR17 RASGRF2 HS6ST2 ST6GALNAC5 PREX1	6.92e-05	182	169	6	bfb725fff3d20066d8ac0a6ba2f88498fcbd876e
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZNF536 GPR17 RASGRF2 HS6ST2 ST6GALNAC5 PREX1	6.92e-05	182	169	6	b4fc5e4f5d8440a3c9ee0a6fd0da87b43cabc8c6
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZNF536 GPR17 RASGRF2 HS6ST2 ST6GALNAC5 PREX1	6.92e-05	182	169	6	f7f9be9c7ef8da9864d6aefe20043b26e1bb8697
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF536 NOG TMPRSS6 ITGA10 TMPRSS5 IGSF21	6.92e-05	182	169	6	a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZNF536 GPR17 RASGRF2 HS6ST2 ST6GALNAC5 PREX1	7.13e-05	183	169	6	f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZNF536 GPR17 RASGRF2 HS6ST2 PPM1E ST6GALNAC5	7.13e-05	183	169	6	e0854864d377e158a4793088d1cb6b3dbf2c805d
ToppCell	LPS-IL1RA\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HIF1A VWF GBP3 JAK2 SEMA6A LYN	7.35e-05	184	169	6	c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DDR1 ZNF536 FOLH1 PLEKHG3 ADAMTS14 PREX1	7.35e-05	184	169	6	a2191dd5546efd357b23e625beb3c5820476f243
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 SZT2 TMPRSS5 ITGA2B FGFR4 IGSF21	7.35e-05	184	169	6	e33bb572af9dfd11127105f1ac99bc958a7cafbb
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 HS6ST2 TLN2 C1QTNF3 FGFR4 TBR1	7.57e-05	185	169	6	5414a66169c39d09a67b1050aad5e61f46b3749a
ToppCell	LPS_only\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HIF1A GBP3 REL NOL10 JAK2 KPNA2	7.57e-05	185	169	6	a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCell	LPS_only-Unknown-Endothelial-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRPC6 PPM1E ITGA10 GALNT9 PLCE1	7.75e-05	115	169	5	c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCell	LPS_only-Unknown-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRPC6 PPM1E ITGA10 GALNT9 PLCE1	7.75e-05	115	169	5	ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCell	LPS_only-Unknown\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRPC6 PPM1E ITGA10 GALNT9 PLCE1	7.75e-05	115	169	5	7a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCell	NS-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP32 NCKAP1 SNHG12 GSDMC CLDN10 GARIN4	7.80e-05	186	169	6	c28f62524637c7eb9c43c9ec38fb12dfec6f5566
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF RASGRF2 CLDN15 FBN1 TLN2 FAM135A	7.80e-05	186	169	6	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 DOCK11 OCRL ST6GALNAC5 IGSF21 CTSZ	7.80e-05	186	169	6	4bb54043f944a979db91bde9a86dd66f498c7658
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF536 NOG SZT2 FAT3 TMPRSS5 TBR1	7.80e-05	186	169	6	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZNF536 GPR17 RASGRF2 HS6ST2 PPM1E ST6GALNAC5	7.80e-05	186	169	6	3113c85d0ac5fc46532c19b1bb71f34b985e1276
ToppCell	PCW_07-8.5-Neuronal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZNF536 GPR17 RASGRF2 HS6ST2 PPM1E ST6GALNAC5	7.80e-05	186	169	6	7a4bb42f3f6a27b463e48eafc587d9ab3386f2fb
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MXRA5 AXL ITGA10 LAMC1 C1R ADAMTS14	7.80e-05	186	169	6	d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF536 ANK1 RASGRF2 DOCK11 AR PLCE1	7.80e-05	186	169	6	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	(2)_5-FU-(2)_LEPR+_perivascular_cells_and_VE-Cad+_vascular_cells_(mixed)\|(2)_5-FU / Stress and Cell class	TMPRSS6 CLDN10 AR FBN1 TLN2 CTSZ	8.03e-05	187	169	6	6bbf0f7fe203274dae8d582652f35cd3187c0065
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 PPM1E ITGA10 PLEKHG3 PITPNM3 PLCE1	8.03e-05	187	169	6	9688141beef4f62613d7a810c5872ccb9afc1a71
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK1 RASGRF2 DOCK11 TRPC6 ST6GALNAC5 NPAS1	8.03e-05	187	169	6	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 PPM1E ITGA10 PLEKHG3 PITPNM3 PLCE1	8.03e-05	187	169	6	dba4924d914a7dcd4901142684ba920c2404860b
ToppCell	COPD-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	ITGA10 GRID1 MED13L AR ZFHX3 PREX1	8.27e-05	188	169	6	1aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 AXL TMPRSS6 LAMC1 FBN1 FGFR4	8.27e-05	188	169	6	7191087d8754f5e8700e3d744cd920ee26db1e57
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP10 AXL TRPC6 HACL1 ZFHX3 PLCE1	8.52e-05	189	169	6	975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCell	facs-Limb_Muscle\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX15 HS6ST2 TMPRSS6 TLN2 C1QTNF3 FGFR4	8.52e-05	189	169	6	21ec43859d21ffc565acbe36489da1d2d0f9877d
ToppCell	facs-Skin-nan-18m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX15 ZNF536 FBN1 C1QTNF3 FGFR4 DNAH6	8.52e-05	189	169	6	29287525120be2953b76881ba3cfc4379c265e7a
ToppCell	facs-Skin-nan-18m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX15 ZNF536 FBN1 C1QTNF3 FGFR4 DNAH6	8.52e-05	189	169	6	7150dad9a92a715487c2d8130fa01b752ea69663
ToppCell	facs-Skin-nan-18m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX15 ZNF536 FBN1 C1QTNF3 FGFR4 DNAH6	8.52e-05	189	169	6	6e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MUSTN1 NOG ANK1 NEK7 CPS1	8.75e-05	118	169	5	d7dcffc0476a6e471debd83904a6569c6f27a594
ToppCell	LPS-IL1RA-Unknown-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS3 GBP3 CLDN10 GALNT9 KPNA2	8.75e-05	118	169	5	aefad0b35aff980b6a2a98057735442e8a65ab04
ToppCell	LPS-IL1RA-Unknown\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS3 GBP3 CLDN10 GALNT9 KPNA2	8.75e-05	118	169	5	6cb4063b83f867b782080ce5b1199b51bb277f2a
ToppCell	15-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	MXRA5 DOCK11 FBN1 GALNT9 C1R C1QTNF3	8.77e-05	190	169	6	b47472dc9fe6ed99c2365203a3d8a59879e74a70
ToppCell	wk_08-11-Epithelial-PNS-Schwann_precursor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	STARD13 ZNF536 RASGRF2 HS6ST2 TMPRSS5 PREX1	8.77e-05	190	169	6	4a777d8aa19cadd3b61b023772df142421a89113
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF536 ANK1 RASGRF2 DOCK11 AR PLCE1	8.77e-05	190	169	6	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	ARHGAP10 AXL FAT3 TRPC6 FBN1 PLCE1	9.02e-05	191	169	6	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
Drug	2-hydroxyisonicotinate	ACO1 IREB2 AGPS	1.51e-06	4	166	3	CID000280756
Disease	lung non-small cell carcinoma (is_implicated_in)	RAD52 DDR1 HIF1A CASP9 JAK2 ZFHX3 FGFR4 MAP2K7	1.11e-06	139	163	8	DOID:3908 (is_implicated_in)
Disease	pulse pressure measurement	MXRA5 PCDHA9 NCKAP1 FOLH1 ANKUB1 FAT3 NEK7 UBAP1 ACAD10 MED13L GSDMC TRIM66 GTF2B FBN1 GALNT9 INTS11 PITPNM3 TLN2 ZFHX3 PLCE1	8.96e-05	1392	163	20	EFO_0005763
Disease	Adenocarcinoma of lung (disorder)	STRBP SUCLG2 RPS6KC1 PIK3CA EIF2B5 FGFR4 KPNA2	1.55e-04	206	163	7	C0152013
Disease	uric acid measurement	IPPK DNAJC13 HLA-DQB2 FAT3 HECTD4 ACAD10 CPS1 BIRC6 SLC29A2 CLDN10 AR GNAT2	1.57e-04	610	163	12	EFO_0004761
Disease	lung adenocarcinoma (is_implicated_in)	JAK2 ZFHX3 FGFR4 MAP2K7	1.57e-04	49	163	4	DOID:3910 (is_implicated_in)
Disease	mean platelet volume	ARHGAP32 VWF DOCK11 NELFCD FOLH1 EML6 DOK2 ITGA2B CPS1 JAK2 GALNT9 TAF7 LYN CTSZ PLCE1 TBX6	1.78e-04	1020	163	16	EFO_0004584
Disease	glycine measurement, amino acid measurement	CPS1 PKD1L2	1.81e-04	4	163	2	EFO_0005134, EFO_0009767
Disease	von Willebrand's disease 1 (is_implicated_in)	VWF ITGA2B	1.81e-04	4	163	2	DOID:0060573 (is_implicated_in)
Disease	Progressive cone dystrophy (without rod involvement)	GUCA1A GNAT2	1.81e-04	4	163	2	C0271092
Disease	nephrotic syndrome type 2 (is_implicated_in)	TRPC6 PLCE1	1.81e-04	4	163	2	DOID:0080379 (is_implicated_in)
Disease	body surface area	NOG ADAMTS3 GRID1 ACAD10 MED13L CPS1 TRIM66 FBN1 MTOR GPR156 ZFHX3 FGFR4	2.53e-04	643	163	12	EFO_0022196
Disease	hepatocellular carcinoma (is_marker_for)	RAD52 DDR1 HIF1A CPS1 JAK2 MTOR ZFHX3 FGFR4	2.83e-04	301	163	8	DOID:684 (is_marker_for)
Disease	porphyria (implicated_via_orthology)	ACO1 IREB2	3.00e-04	5	163	2	DOID:13268 (implicated_via_orthology)
Disease	Neoplasm of the genitourinary tract	AR PIK3CA ZFHX3	3.08e-04	24	163	3	cv:C0042065
Disease	colon adenocarcinoma (is_implicated_in)	JAK2 PIK3CA MAP2K7	3.92e-04	26	163	3	DOID:234 (is_implicated_in)
Disease	mean corpuscular hemoglobin concentration	RAD52 DNAJC13 ANK1 AXL TMPRSS6 HECTD4 IREB2 ACAD10 CPS1 SUCLG2 STT3A PIK3CA GALNT9 MAP2K7 PREX1 TBX6	4.32e-04	1105	163	16	EFO_0004528
Disease	parental longevity	ADAMTS3 HLA-DQB2 HECTD4 IREB2 LAMC1 CPS1 PKD1L2 PHLPP1 HACL1 ZW10	4.45e-04	494	163	10	EFO_0007796
Disease	Neonatal Alloimmune Thrombocytopenia	CD109 ITGA2B	4.48e-04	6	163	2	C3853779
Disease	FNAITP	CD109 ITGA2B	4.48e-04	6	163	2	C3854603
Disease	essential thrombocythemia (is_implicated_in)	VWF JAK2	4.48e-04	6	163	2	DOID:2224 (is_implicated_in)
Disease	Hemimegalencephaly	PIK3CA MTOR	4.48e-04	6	163	2	C0431391
Disease	varicocele (biomarker_via_orthology)	HIF1A CASP9	4.48e-04	6	163	2	DOID:12337 (biomarker_via_orthology)
Disease	prostate cancer (is_implicated_in)	HIF1A AR MTOR ZFHX3 FGFR4	4.92e-04	117	163	5	DOID:10283 (is_implicated_in)
Disease	Colorectal Carcinoma	CPAMD8 RASGRF2 FOLH1 FRMPD2 PPM1E CD109 LAMC1 GRID1 GTF2B PIK3CA IGSF21 SNRNP200	5.55e-04	702	163	12	C0009402
Disease	esophageal carcinoma	HECTD4 ACAD10 PLCE1	6.02e-04	30	163	3	EFO_0002916
Disease	neutrophil count	IPPK TBX15 CPAMD8 DNAJC13 PCDHA9 HLA-DQB2 EML6 HECTD4 NEK7 DOK2 CPS1 JAK2 SNX27 TLN2 PXYLP1 FGFR4 LYN PREX1	6.59e-04	1382	163	18	EFO_0004833
Disease	Prostatic Neoplasms	DDR1 HIF1A ACRBP FOLH1 CASP9 LAMC1 AR JAK2 PIK3CA ZFHX3 FGFR4	6.61e-04	616	163	11	C0033578
Disease	Malignant neoplasm of prostate	DDR1 HIF1A ACRBP FOLH1 CASP9 LAMC1 AR JAK2 PIK3CA ZFHX3 FGFR4	6.61e-04	616	163	11	C0376358
Disease	myeloid white cell count	IPPK TBX15 DNAJC13 TRPC6 EML6 HECTD4 ITGA10 CPS1 TLN2 ZFHX3 PXYLP1 LYN PREX1 PLCE1	7.34e-04	937	163	14	EFO_0007988
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	VWF FBN1	8.31e-04	8	163	2	DOID:4783 (biomarker_via_orthology)
Disease	carbohydrate intake measurement	HECTD4 ACAD10 ZFHX3	8.73e-04	34	163	3	EFO_0010811
Disease	retinal detachment, retinal break	CPAMD8 NOG FAT3	9.51e-04	35	163	3	EFO_0005773, EFO_0010698
Disease	Erythrocytosis familial, 1	HIF1A JAK2	1.06e-03	9	163	2	C4551637
Disease	alcoholic liver cirrhosis (is_marker_for)	DDR1 JAK2	1.06e-03	9	163	2	DOID:14018 (is_marker_for)
Disease	Marfan Syndrome, Type I	LAMC1 FBN1	1.06e-03	9	163	2	C4721845
Disease	Malignant tumor of prostate	AR ZFHX3	1.06e-03	9	163	2	cv:C0376358
Disease	facial depth measurement	NOG TRPC6	1.06e-03	9	163	2	EFO_0007857
Disease	Developmental delay (disorder)	SZT2 ACTL6A STT3A	1.12e-03	37	163	3	C0424605
Disease	proteinuria (biomarker_via_orthology)	HIF1A TRPC6	1.33e-03	10	163	2	DOID:576 (biomarker_via_orthology)
Disease	liver fibrosis measurement	VWF TMPRSS11E NOL10 HMGCR	1.34e-03	86	163	4	EFO_0010576
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	HIF1A NOG TRPC6 FBN1 MTOR	1.38e-03	147	163	5	DOID:9352 (biomarker_via_orthology)
Disease	Retinal Detachment	CPAMD8 CASP9	1.61e-03	11	163	2	C0035305
Disease	3-methylglutarylcarnitine (2) measurement	CPS1 SUCLG2	1.61e-03	11	163	2	EFO_0800074
Disease	Marfan Syndrome	LAMC1 FBN1	1.61e-03	11	163	2	C0024796
Disease	hypertension	ANK1 SZT2 FOLH1 TRPC6 EML6 HECTD4 PLCE1	1.65e-03	307	163	7	EFO_0000537
Disease	body weight	IPPK RAD52 ADAMTS3 NELFCD AOAH HECTD4 GRID1 CPS1 TRIM66 MTOR TLN2 ZFHX3 PXYLP1 FGFR4 ADAMTS14 GNAT2	1.73e-03	1261	163	16	EFO_0004338
Disease	nasopharynx carcinoma (is_marker_for)	RAD52 JAK2 FGFR4	1.74e-03	43	163	3	DOID:9261 (is_marker_for)
Disease	Non-Small Cell Lung Carcinoma	HIF1A MXRA5 AXL PIK3CA MTOR	1.79e-03	156	163	5	C0007131
Disease	Thyroid carcinoma	HIF1A PIK3CA MTOR	1.86e-03	44	163	3	C0549473
Disease	platelet measurement	VWF HLA-DQB2 EML6 ACAD10 ITGA2B CPS1 CTSZ	1.91e-03	315	163	7	EFO_0005036
Disease	bronchopulmonary dysplasia (biomarker_via_orthology)	HIF1A CASP9	1.93e-03	12	163	2	DOID:11650 (biomarker_via_orthology)
Disease	reticulocyte measurement	RAD52 VWF ANK1 HLA-DQB2 TMPRSS6 ACTR10 EML6 HECTD4 UBAP1 BIRC6 AR PIK3CA TLN2 PREX1	2.19e-03	1053	163	14	EFO_0010700
Disease	skin melanoma (is_marker_for)	DDR1 HIF1A	2.27e-03	13	163	2	DOID:8923 (is_marker_for)
Disease	blood cobalt measurement	AOAH GSDMC ST6GALNAC5 ADAMTS14	2.42e-03	101	163	4	EFO_0007577
Disease	urinary metabolite measurement	FOLH1 TMPRSS11E IREB2 CPS1 SUCLG2 GTF2B	2.48e-03	245	163	6	EFO_0005116
Disease	Malignant neoplasm of breast	HIF1A VWF ANK1 RASGRF2 STRBP TMPRSS6 SPTAN1 PPM1E CD109 MAP3K6 AR PIK3CA MTOR MAP2K7	2.62e-03	1074	163	14	C0006142
Disease	Malformations of Cortical Development	PIK3CA MTOR	2.64e-03	14	163	2	C1955869
Disease	C-C motif chemokine 19 measurement	DNAJC13 HLA-DQB2	2.64e-03	14	163	2	EFO_0008047
Disease	Cortical Dysplasia	PIK3CA MTOR	2.64e-03	14	163	2	C0431380
Disease	type 2 diabetes mellitus (is_implicated_in)	HIF1A AXL CASP9 HMGCR MTOR	2.66e-03	171	163	5	DOID:9352 (is_implicated_in)
Disease	infant head circumference	STRBP PREX1	3.04e-03	15	163	2	EFO_0004577
Disease	hepcidin:transferrin saturation ratio	TMPRSS6 EML6	3.04e-03	15	163	2	EFO_0007902
Disease	lymphocyte count	IPPK ANK1 STRBP HLA-DQB2 EML6 HECTD4 ACAD10 DOK2 MED13L CPS1 CC2D2B GTF2B FBN1 PHLPP1 PREX1 CTSZ PLCE1	3.13e-03	1464	163	17	EFO_0004587
Disease	platelet component distribution width	VWF NELFCD HLA-DQB2 TMPRSS6 DOK2 ITGA2B CPS1 PLEKHG3 LYN PREX1 CTSZ	3.28e-03	755	163	11	EFO_0007984
Disease	diabetic retinopathy (is_marker_for)	HIF1A VWF CASP9	3.34e-03	54	163	3	DOID:8947 (is_marker_for)
Disease	focal segmental glomerulosclerosis	FGFR4 DNAH6	3.46e-03	16	163	2	EFO_0004236
Disease	preeclampsia, hypertension, pregnancy-induced	PREX1 PLCE1	3.46e-03	16	163	2	EFO_0000668, MONDO_0024664
Disease	succinylcarnitine measurement	ZNF536 SUCLG2	3.46e-03	16	163	2	EFO_0020020
Disease	creatinine measurement	HIF1A DNAJC13 NOG DHX40 CASP9 ACAD10 CPS1 BIRC6 AR GTF2B ZFHX3 FGFR4 IGSF21	3.64e-03	995	163	13	EFO_0004518
Disease	Neoplasm Invasiveness	TBX15 HIF1A AXL ACO1 IREB2	3.64e-03	184	163	5	C0027626
Disease	heart failure	HLA-DQB2 HECTD4 ACAD10 OCRL ZFHX3	3.73e-03	185	163	5	EFO_0003144
Disease	heart disease (biomarker_via_orthology)	CASP9 JAK2	3.91e-03	17	163	2	DOID:114 (biomarker_via_orthology)
Disease	high altitude adaptation	HLA-DQB2 NEK7	3.91e-03	17	163	2	EFO_0009105
Disease	Carcinoma, Granular Cell	DDR1 PIK3CA MTOR PLCE1	3.98e-03	116	163	4	C0205644
Disease	Adenocarcinoma, Tubular	DDR1 PIK3CA MTOR PLCE1	3.98e-03	116	163	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	DDR1 PIK3CA MTOR PLCE1	3.98e-03	116	163	4	C0205642
Disease	Carcinoma, Cribriform	DDR1 PIK3CA MTOR PLCE1	3.98e-03	116	163	4	C0205643
Disease	Adenocarcinoma, Basal Cell	DDR1 PIK3CA MTOR PLCE1	3.98e-03	116	163	4	C0205641
Disease	Adenocarcinoma	DDR1 PIK3CA MTOR PLCE1	3.98e-03	116	163	4	C0001418
Disease	Abnormality of refraction	ARHGAP32 DNAJC13 PCDHA9 NOG FAT3 FRMPD2 BIRC6 FBN1 ZFHX3 KPNA2	4.35e-03	673	163	10	HP_0000539
Disease	serum hepcidin measurement	TMPRSS6 EML6	4.38e-03	18	163	2	EFO_0004504
Disease	smoking behavior, BMI-adjusted waist circumference	TBX15 ADAMTS3 FGFR4 PREX1	4.76e-03	122	163	4	EFO_0004318, EFO_0007789
Disease	prion disease	PXYLP1 ADAMTS14	4.88e-03	19	163	2	EFO_0004720
Disease	portal hypertension (implicated_via_orthology)	JAK2 MTOR	4.88e-03	19	163	2	DOID:10762 (implicated_via_orthology)
Disease	polycystic kidney disease (biomarker_via_orthology)	HIF1A MTOR	4.88e-03	19	163	2	DOID:0080322 (biomarker_via_orthology)
Disease	factor VIII measurement, Ischemic stroke	VWF HECTD4	4.88e-03	19	163	2	EFO_0004630, HP_0002140
Disease	transient cerebral ischemia (implicated_via_orthology)	VWF TRPC6 JAK2	5.39e-03	64	163	3	DOID:224 (implicated_via_orthology)
Disease	susceptibility to hepatitis B infection measurement	HLA-DQB2 EML6 PREX1	5.39e-03	64	163	3	EFO_0008405
Disease	body fat distribution	ADAMTS3 AOAH FGFR4 ADAMTS14 PLCE1	5.39e-03	202	163	5	EFO_0004341
Disease	end stage renal disease (implicated_via_orthology)	HMGCR MTOR	5.40e-03	20	163	2	DOID:783 (implicated_via_orthology)
Disease	neoplasm of mature B-cells	HLA-DQB2 PHLPP1	5.40e-03	20	163	2	EFO_0000096

Protein segments in the cluster

Peptide	Gene	Start	Entry
ADRDMECLSQYPSLS	PRAMEF33	306	A0A0G2JMD5
PGIRSIMSSAIAYLC	TMEM62	241	Q0P6H9
ADRATIANMCPEYGA	ACO1	291	P21399
QSCLIPAMSSYLRND	BIRC6	4366	Q9NR09
MVTEAIAYLRACLNP	CXCR6	271	O00574
PISCGIMATERLANY	CTSZ	211	Q9UBR2
RMRCLQNETYSALSP	ACRBP	506	Q8NEB7
MSRLCQDYDTIGPEG	ANK1	1066	P16157
CRYALGMQDRTIPDS	DDR1	31	Q08345
EMVGYCAARSEGLLP	GSDMC	246	Q9BYG8
SCLTSLNGALDPIMY	GPR17	311	Q13304
MESVVPSDRGTYTCL	FGFR4	211	P22455
TSVGMCDIDIRPGLY	ACTL6A	331	O96019
TYICDAMELGPQRAL	ALPK3	496	Q96L96
CSAPDTGNMELLVRY	ACAD10	756	Q6JQN1
GNCRSLLFVMDASDP	ARL16	96	Q0P5N6
LAQACMDLGYPLELG	CCDC22	71	O60826
FPSMLALDGYIQACR	CLDN10	66	P78369
GYPTSFMSLRCLLSD	PDSS2	61	Q86YH6
ICLPDNDTFYDLGLM	C1R	576	P00736
YCSMLRNVDARSVPG	CC2D2B	646	Q6DHV5
AMVLDCGYRESLVLP	ACTR10	136	Q9NZ32
LPGINYSMDEQCRFD	ADAMTS14	471	Q8WXS8
YCDMTESNPLERRLP	CRISP1	81	P54107
LLYTVLRCSAMPTEG	PCDHA9	716	Q9Y5H5
SYSLPRLECSGAIMA	PACRG	206	Q96M98
EEARYNSCRPNMALG	RAD52	201	P43351
DTLSGYAMCLPNLTR	IPPK	106	Q9H8X2
VDRTTIANMCPEYGA	IREB2	366	P48200
GSVEMCRYDPLQDNT	JAK2	861	O60674
SGMEVETICRYNLPI	HACL1	461	Q9UJ83
MDLGPSELVGRSCYQ	NPAS1	326	Q99742
TVQASMERLCSYLPE	AOAH	61	P28039
MGLQPLEFSDCYLDS	ARHGAP10	1	A1A4S6
YQVMRECEQAGSAAP	MUSTN1	41	Q8IVN3
AAMAYDRAVAISCPL	OR1A2	116	Q9Y585
GKQSRPCMEENELYS	DOK2	126	O60496
LPLMAEVSETALYCG	MED13L	606	Q71F56
MQNRLPCIYLVDSGG	MCCC2	161	Q9HCC0
AASYPRACQALGAML	NELFCD	286	Q8IXH7
LRVNCYMPANGETVT	INTS11	431	Q5TA45
DAIERMYCAPEVGAI	RPS6KC1	961	Q96S38
DRAILYPCHGMSSQL	GALNT9	486	Q9HCQ5
MLLARPATGCEEYAG	GARIN4	86	Q8IYT1
SMDESGLPQLTSYDC	HIF1A	786	Q16665
MEASGPTNEDLYISC	HMGCR	781	P04035
IEGNYTLRVDCTPLM	FOLH1	456	Q04609
GRQMLSPYCDTLRSN	LMLN	411	Q96KR4
MLEITPQRGDIYTCQ	HLA-DQB2	191	P05538
QQMDSPLDSSRYCAL	EIF2B5	606	Q13144
LVQLEGSVAPDLYCM	MAP3K6	341	O95382
DYLRDGINMPTVCTS	FAM135A	1136	Q9P2D6
RSAGCAAYMAPERID	MAP2K7	276	O14733
SLGCLLYEMAALQSP	NEK7	221	Q8TDX7
GELATVECYNPRMNE	KLHL9	411	Q9P2J3
LTYINAISRGDLPCM	GBP3	296	Q9H0R5
EQLRGDCMYAPLLGV	AR	261	P10275
SLDDMLLDCRFRGQP	ASIC3	156	Q9UHC3
NDVCLYPNSGMLLTA	NOL10	316	Q9BSC4
YSFRGAPMLLAENCS	ODF3	51	Q96PU9
ACSMLRILYNGPEIT	HECTD4	786	Q9Y4D8
AGSPDSRYIRVETCM	HECTD4	3951	Q9Y4D8
GEMLGNRCNSYDNLP	ARHGAP32	741	A7KAX9
YCRALNSMGQDLERP	DSG1	126	Q02413
NQGLDLRMLPYGCLS	PIK3CA	826	P42336
MNVYELSSAAGLPCE	NCKAP1	956	Q9Y2A7
NGCRAPYSLDAEDMA	PKD1L2	2051	Q7Z442
AMTTQCRSSYLPGEL	KCNJ14	311	Q9UNX9
GEQIYRMQSLSPVCS	PPM1E	636	Q8WY54
ALLAVPDMSSLACGY	KPNA2	211	P52292
PDMSSLACGYLRNLT	KPNA2	216	P52292
LCQDEYMESPQTGGL	C1QTNF3	21	Q9BXJ4
RMFLDQCVDGSTALP	EBLN1	241	P0CF75
CLLRPSYVLSGSAMN	CPS1	1126	P31327
LPGINYSMDEQCRFD	ADAMTS3	471	O15072
LASLIRMPYGCGEQN	CD109	911	Q6YHK3
VITPLTDRCYLCLMG	DNAH6	1446	Q9C0G6
MPNLYGDILSDLCAG	IDH3A	251	P50213
RVPAELNGSMYRCTA	IGSF21	401	Q96ID5
LAGRDTLYSCAAMPN	DOCK11	1181	Q5JSL3
CSPDADMLDYLLSLG	FAM151A	46	Q8WW52
GFALMPDQRSCTDID	FBN1	1226	P35555
TGASREMAPFLRCQE	GAS2L2	351	Q8NHY3
VCDIMRLGRYSFSSP	FRMPD2	1286	Q68DX3
RGNADLAYILSMEPC	CASP9	146	P55211
ESAAPLAMDPYSCAL	CPAMD8	1301	Q8IZJ3
GDMQCVSYEASRRPF	FAT3	3806	Q8TDW7
MICDARIYSGSLLSP	GFOD2	146	Q3B7J2
PSMLALSGYIQACRA	CLDN15	66	P56746
LITMCGYFPSRDQDN	DNAJC13	1051	O75165
MTECPSGQLTLYEFR	GUCA1A	26	P43080
LSQGYRMPRVENCPD	LYN	456	P07948
RCPTYMDVVIVLDGS	ITGA10	161	O75578
LMSAECTYDLPEGAA	GPR156	386	Q8NFN8
ISSLLCDPQEGYLQM	GRID1	301	Q9ULK0
DLTLVGCYNLSVMPE	HS6ST2	396	Q96MM7
CEMCLSGYRRETPNL	LAMC1	701	P11047
AATLGVNPCTAYRML	MECR	161	Q9BV79
QMPDSLRSGEYLHNC	AHCTF1	411	Q8WYP5
ARCAAYSPDGEMVAI	EML6	1731	Q6ZMW3
DGLLILPCYGSMTTD	DHX40	311	Q8IX18
LPCYGSMTTDQQRRI	DHX40	316	Q8IX18
YGGLERLCRDMQSIL	RUBCN	51	Q92622
RPVFDYRCMVSGSEQ	CMTR1	586	Q8N1G2
MERCPSLGVTLYALV	NOG	1	Q13253
LMCRDLELAVPGTYD	MTOR	2131	P42345
ICQMLVSTVDGDLYP	TAF7	91	Q15545
PRDAACIGSMLSFEY	SZT2	941	Q5T011
DESCAPRGYLAATMQ	SZT2	2016	Q5T011
RAVVMDSQYLIEPCG	STARD13	1046	Q9Y3M8
SNGYLVSLTMCLAPR	SLC29A2	406	Q14542
DTIYTGCDMDRLTPS	TBR1	396	Q16650
VLICDYGPMELGQSL	SNHG12	36	Q9BXW3
LEEDMKCLSQYPSLG	PRAMEF14	306	Q5SWL7
SGLMKLCPRYNSQEE	PLCE1	721	Q9P212
NYPNSVAALTECMRD	PLEKHG3	186	A1L390
YEANPACEGRMLETF	RASGRF2	366	O14827
QLEVSGLLGEMNCPY	FAM98A	76	Q8NCA5
RAMTTLGIDYAEPSC	GNAT2	86	P19087
APAYRLQDCDALVTM	PRKY	41	O43930
LSDYPPCARSNMAAL	TBX15	396	Q96SF7
PISSELCYRLGACQM	PREX1	1566	Q8TCU6
VDREGSPVLLNCLMY	STT3A	626	P46977
LDACRVAPYVNMGAL	SHOX	191	O15266
ALELCDRINVYGMVP	ST6GALNAC5	241	Q9BVH7
PCERDPTDALSYMTI	STRBP	286	Q96SI9
LEEDMKCLSQYPSLG	PRAMEF1	306	O95521
LYCNIPSVAERSMEG	PXYLP1	66	Q8TE99
DLLVGAPLYMESRAD	ITGA2B	336	P08514
RLSCTDPSINELMIY	OR5K4	186	A6NMS3
GDLNYRLCMPDANEV	OCRL	421	Q01968
GAMAVDRYVAVCNPL	OR9A4	116	Q8NGU2
VSYGLMCPADETRTI	AGPS	241	O00116
TPRGLEMYDCNTLKD	ANKUB1	131	A6NFN9
QAYNDAITPRMLCAG	TMPRSS11E	346	Q9UL52
DAYMTRSLNPALDGL	WDR47	306	O94967
ETYLAILMDRSCNGP	SUCLG2	151	Q96I99
VMLENYRNLISVGCP	ZNF684	36	Q5T5D7
GCGIMFPRDYILDSE	SPRYD3	326	Q8NCJ5
NPSRYCSMLIEEGGL	ZYG11B	681	Q9C0D3
APLCLSQQLRMKGDY	TAS1R3	21	Q7RTX0
AYSELQMLSPSERQC	UBAP1	381	Q9NZ09
AYRTPTMQECEVLGE	ZFHX2	2086	Q9C0A1
PALLEYARTCAQEGM	VWF	266	P04275
SYCMLQGSPLDVLKD	MIOS	676	Q9NXC5
AILVEDYRAGDMICP	GTF2B	21	Q00403
SIPGSAVCAYDMLDI	SEMA6A	321	Q9H2E6
CLRSLGYDLPMVEEG	SPTAN1	2351	Q13813
LYCQKGLSMTVEADP	TEX101	26	Q9BY14
PADCLDGLYALMSRC	AXL	771	P30530
SGALTPRMLCAGYLD	TMPRSS5	381	Q9H3S3
NMLRTCEGYNEIIFP	SNX27	416	Q96L92
LDCFLSGMEAAPRTL	TBX6	46	O95947
DLYGISDPNMLSNCS	REL	481	Q04864
SIPTRGLCNFLMSDE	GTF3C4	706	Q9UKN8
RYMSLAVCELDQPGL	WDR6	861	Q9NNW5
DQTCAMSYLTVLPRG	PITPNM3	721	Q9BZ71
DGAIPAMYLDCISDL	ZNF862	271	O60290
LRDRSLGSAMKDCPY	ZNF536	741	O15090
SSEGRCVYITPMEAL	SNRNP200	1371	O75643
EPIGRYDQATDTIMC	TLN2	796	Q9Y4G6
CYHEMSGPQEALSRL	ZKSCAN7	61	Q9P0L1
GDRNVEVPYLLQCTM	PHLPP1	1211	O60346
QSLYRRMEGCSGPVL	TLDC2	91	A0PJX2
YLLMDSELGEDGCPQ	TRPC6	31	Q9Y210
RVDNALSTEMTPCYI	TRIM64C	286	A6NLI5
CTLCRSLTQPEMEYD	TRIM66	1011	O15016
GPARAAEEVMCYTSL	SIT1	116	Q9Y3P8
DMDRTQIELNPYLTC	KIAA0586	1466	Q9BVV6
AECRDRLAMYDVAGP	TMPRSS6	266	Q8IU80
RLYSLCKTVMDEGPQ	ZW10	681	O43264
NDYRTPTMLECEVLG	ZFHX3	2966	Q15911
LESEECRMSGEYPNS	KRT72	431	Q14CN4
RIKSMEPSDSGLYQC	MXRA5	541	Q9NR99