Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	symbiont cell surface	CFH CFHR4	2.63e-04	8	65	2	GO:0106139
GeneOntologyCellularComponent	other organism part	CFH CFHR4	3.38e-04	9	65	2	GO:0044217
MousePheno	white pupil	CFH CFHR4	1.15e-05	2	48	2	MP:0006242
MousePheno	decreased serum complement activity	CFH CFHR4	1.15e-05	2	48	2	MP:0012553
MousePheno	artery occlusion	CFH CFHR4	1.15e-05	2	48	2	MP:0006134
MousePheno	decreased complement C5 level	CFH CFHR4	1.15e-05	2	48	2	MP:0012609
MousePheno	abnormal complement C5 level	CFH CFHR4	1.15e-05	2	48	2	MP:0012608
MousePheno	abnormal hepatic portal vein thrombosis	CFH CFHR4	1.15e-05	2	48	2	MP:0031159
MousePheno	increased susceptilbility to retina ischemic injury	CFH CFHR4	3.46e-05	3	48	2	MP:0012049
MousePheno	abnormal kidney venous thrombosis	CFH CFHR4	3.46e-05	3	48	2	MP:0031161
MousePheno	abnormal response to retina ischemic injury	CFH CFHR4	6.90e-05	4	48	2	MP:0012048
MousePheno	increased susceptibility to type III hypersensitivity reaction	CFH CFHR4	6.90e-05	4	48	2	MP:0005615
MousePheno	decreased circulating complement protein level	CFH CFHR4	6.90e-05	4	48	2	MP:0020216
MousePheno	mesangial cell interposition	CFH CFHR4	6.90e-05	4	48	2	MP:0011512
MousePheno	abnormal brain thrombosis	CFH CFHR4	6.90e-05	4	48	2	MP:0031168
MousePheno	increased creatine level	CFH CFHR4	6.90e-05	4	48	2	MP:0010061
MousePheno	abnormal venous thrombosis	CFH CFHR4	1.15e-04	5	48	2	MP:0031158
MousePheno	abnormal lung thrombosis	CFH CFHR4	1.15e-04	5	48	2	MP:0031167
MousePheno	increased mesangial cell number	CFH NFE2L2 CFHR4	1.30e-04	29	48	3	MP:0011427
MousePheno	abnormal circulating complement protein level	CFH CFHR4	1.72e-04	6	48	2	MP:0010215
MousePheno	abnormal glomerular capillary thrombosis	CFH CFHR4	2.40e-04	7	48	2	MP:0011508
MousePheno	abnormal capillary morphology	CFH COL15A1 NFE2L2 CFHR4	2.86e-04	93	48	4	MP:0003658
MousePheno	abnormal mesangial cell morphology	CFH NFE2L2 CFHR4	2.95e-04	38	48	3	MP:0005327
MousePheno	brain ischemia	CFH CFHR4	3.19e-04	8	48	2	MP:0006080
MousePheno	abnormal complement protein level	CFH CFHR4	4.09e-04	9	48	2	MP:0011566
MousePheno	abnormal creatine level	CFH CFHR4	4.09e-04	9	48	2	MP:0010060
MousePheno	abnormal type III hypersensitivity reaction	CFH CFHR4	5.11e-04	10	48	2	MP:0002533
MousePheno	abnormal kidney thrombosis	CFH CFHR4	5.11e-04	10	48	2	MP:0011507
MousePheno	abnormal glomerular capillary morphology	CFH NFE2L2 CFHR4	5.54e-04	47	48	3	MP:0011320
MousePheno	abnormal kidney capillary morphology	CFH NFE2L2 CFHR4	5.90e-04	48	48	3	MP:0011310
MousePheno	increased number of Howell-Jolly bodies	SIN3B NFE2L2	6.23e-04	11	48	2	MP:0010178
MousePheno	circling	CFH NFE2L2 KCNQ1 CFHR4	6.83e-04	117	48	4	MP:0001394
MousePheno	increased susceptibility to injury	CFH RNLS NFE2L2 NEB CFHR4	7.08e-04	208	48	5	MP:0005165
MousePheno	abnormal visual acuity	CFH CFHR4	8.79e-04	13	48	2	MP:0011832
MousePheno	decreased visual acuity	CFH CFHR4	8.79e-04	13	48	2	MP:0006149
MousePheno	abnormal Bruch membrane morphology	CFH CFHR4	1.02e-03	14	48	2	MP:0005239
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	IKZF2 BBX CTCF NFE2L2 ZNF207 FOXJ3 ZC3H6 MNT PLXNA2 ZNF687	2.45e-06	808	65	10	20412781
Pubmed	Absence of complement factor H reduces physical performance in C57BL6 mice.	CFH CFHR4	3.44e-06	2	65	2	32962822
Pubmed	Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.	CFH CFHR4	3.44e-06	2	65	2	20538999
Pubmed	Inheritance, hormonal regulation and properties of polymorphic murine antigens Mud1 and Mud2.	CFH CFHR4	3.44e-06	2	65	2	4992636
Pubmed	Retinal changes precede visual dysfunction in the complement factor H knockout mouse.	CFH CFHR4	3.44e-06	2	65	2	23844226
Pubmed	Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy.	CFH CFHR4	3.44e-06	2	65	2	26374608
Pubmed	A gene locus concerned with an antigenic serum substance in Mus musculus.	CFH CFHR4	3.44e-06	2	65	2	4955525
Pubmed	Analysis of complement factor H mRNA expression: dexamethasone and IFN-gamma increase the level of H in L cells.	CFH CFHR4	3.44e-06	2	65	2	2533512
Pubmed	Complement factor H: spatial and temporal expression and localization in the eye.	CFH CFHR4	3.44e-06	2	65	2	16936129
Pubmed	Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration.	CFH CFHR4	3.44e-06	2	65	2	33558624
Pubmed	Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.	CFH CFHR4	3.44e-06	2	65	2	37940659
Pubmed	Comparative analysis of the properties and ligand binding characteristics of CspZ, a factor H binding protein, derived from Borrelia burgdorferi isolates of human origin.	CFH CFHR4	3.44e-06	2	65	2	19620346
Pubmed	Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.	CFH CFHR4	3.44e-06	2	65	2	30705315
Pubmed	A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in C. elegans cilia.	CFH CFHR4	3.44e-06	2	65	2	33859044
Pubmed	Regulation of age-related macular degeneration-like pathology by complement factor H.	CFH CFHR4	3.44e-06	2	65	2	25991857
Pubmed	Serological survey of complement factor H in common laboratory and wild mice: a new third allotype.	CFH CFHR4	3.44e-06	2	65	2	2522412
Pubmed	Absence of complement factor H alters bone architecture and dynamics.	CFH CFHR4	3.44e-06	2	65	2	30107932
Pubmed	Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice.	CFH CFHR4	3.44e-06	2	65	2	34054871
Pubmed	Factor H binding to PspC of Streptococcus pneumoniae increases adherence to human cell lines in vitro and enhances invasion of mouse lungs in vivo.	CFH CFHR4	3.44e-06	2	65	2	17562771
Pubmed	Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.	CFH CFHR4	3.44e-06	2	65	2	27397653
Pubmed	Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration.	CFH CFHR4	3.44e-06	2	65	2	29392311
Pubmed	The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.	CFH CFHR4	3.44e-06	2	65	2	22174452
Pubmed	Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.	CFH CFHR4	3.44e-06	2	65	2	22875704
Pubmed	Local complement factor H protects kidney endothelial cell structure and function.	CFH CFHR4	3.44e-06	2	65	2	34139209
Pubmed	Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.	CFH CFHR4	3.44e-06	2	65	2	32849636
Pubmed	Complement factor h is critical in the maintenance of retinal perfusion.	CFH CFHR4	3.44e-06	2	65	2	19541934
Pubmed	Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.	CFH CFHR4	3.44e-06	2	65	2	17921253
Pubmed	The role of complement dysregulation in AMD mouse models.	CFH CFHR4	3.44e-06	2	65	2	24664701
Pubmed	Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.	CFH CFHR4	3.44e-06	2	65	2	26149919
Pubmed	Murine protein H is comprised of 20 repeating units, 61 amino acids in length.	CFH CFHR4	3.44e-06	2	65	2	2940596
Pubmed	A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.	CFH CFHR4	3.44e-06	2	65	2	32165615
Pubmed	Death by color: differential cone loss in the aging mouse retina.	CFH CFHR4	3.44e-06	2	65	2	24929970
Pubmed	Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.	CFH CFHR4	3.44e-06	2	65	2	23436934
Pubmed	Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model.	CFH CFHR4	3.44e-06	2	65	2	23469078
Pubmed	Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness.	CFH CFHR4	3.44e-06	2	65	2	15574507
Pubmed	Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules.	CFH CFHR4	3.44e-06	2	65	2	23133374
Pubmed	Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding.	CFH CFHR4	3.44e-06	2	65	2	1486806
Pubmed	Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.	CFH CFHR4	3.44e-06	2	65	2	17517971
Pubmed	Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice.	CFH CFHR4	3.44e-06	2	65	2	20445496
Pubmed	High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.	CFH CFHR4	3.44e-06	2	65	2	32737203
Pubmed	Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease.	CFH CFHR4	3.44e-06	2	65	2	16597679
Pubmed	Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.	CFH CFHR4	3.44e-06	2	65	2	25447048
Pubmed	Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.	CFH CFHR4	3.44e-06	2	65	2	31354740
Pubmed	Prediction from sequence comparisons of residues of factor H involved in the interaction with complement component C3b.	CFH CFHR4	3.44e-06	2	65	2	8615824
Pubmed	Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site.	CFH CFHR4	3.44e-06	2	65	2	30642982
Pubmed	Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.	CFH CFHR4	3.44e-06	2	65	2	29398083
Pubmed	Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.	CFH CFHR4	3.44e-06	2	65	2	29288229
Pubmed	Tumour extracellular vesicle-derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement-dependent cytotoxicity of tumour cells.	CFH CFHR4	3.44e-06	2	65	2	33708358
Pubmed	Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration.	CFH CFHR4	3.44e-06	2	65	2	28819420
Pubmed	Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.	CFH CFHR4	3.44e-06	2	65	2	23799019
Pubmed	Intron-less processed Pcdhalpha genes in the central nervous system.	PCDHA8 PCDHA6	3.44e-06	2	65	2	14697259
Pubmed	Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice.	CFH CFHR4	3.44e-06	2	65	2	24370827
Pubmed	Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation.	FLNB SBF2	3.44e-06	2	65	2	19039035
Pubmed	Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.	CFH CFHR4	3.44e-06	2	65	2	25921262
Pubmed	Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice.	CFH CFHR4	3.44e-06	2	65	2	30808757
Pubmed	Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury.	CFH CFHR4	3.44e-06	2	65	2	21544060
Pubmed	Single nucleotide polymorphisms in Renalase and KCNQ1 genes and female infertility: A cross-sectional study in Pakistan.	RNLS KCNQ1	3.44e-06	2	65	2	31579970
Pubmed	Role of ocular complement factor H in a murine model of choroidal neovascularization.	CFH CFHR4	3.44e-06	2	65	2	20813971
Pubmed	A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice.	CFH CFHR4	3.44e-06	2	65	2	26030099
Pubmed	Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits.	CFH CFHR4	3.44e-06	2	65	2	31133737
Pubmed	AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model.	CFH CFHR4	3.44e-06	2	65	2	37471073
Pubmed	Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease.	CFH CFHR4	3.44e-06	2	65	2	26802141
Pubmed	Structure of the murine complement factor H gene.	CFH CFHR4	3.44e-06	2	65	2	2972715
Pubmed	Complement factor H deficiency combined with smoking promotes retinal degeneration in a novel mouse model.	CFH CFHR4	3.44e-06	2	65	2	34775843
Pubmed	Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H.	CFH CFHR4	1.03e-05	3	65	2	12091909
Pubmed	Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis.	CFH CFHR4	1.03e-05	3	65	2	29070671
Pubmed	Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency.	CFH CFHR4	1.03e-05	3	65	2	23184055
Pubmed	Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21.	GATD3 TRAPPC10	1.03e-05	3	65	2	9205129
Pubmed	Interaction of iron status with single nucleotide polymorphisms on incidence of type 2 diabetes.	KCNQ1 JMJD1C	1.03e-05	3	65	2	28406950
Pubmed	Complement factor H-deficient mice develop spontaneous hepatic tumors.	CFH CFHR4	1.03e-05	3	65	2	32369457
Pubmed	Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice.	CFH CFHR4	1.03e-05	3	65	2	16769899
Pubmed	Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells.	CFH CFHR4	1.03e-05	3	65	2	19084272
Pubmed	Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM.	CFH CFHR4	1.03e-05	3	65	2	29389016
Pubmed	Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily.	CFH CFHR4	1.03e-05	3	65	2	29895552
Pubmed	Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.	CFH CFHR4	1.03e-05	3	65	2	19828624
Pubmed	Structural polymorphism of murine complement factor H controlled by a locus located between the Hc and the beta 2M locus on the second chromosome of the mouse.	CFH CFHR4	1.03e-05	3	65	2	3156187
Pubmed	Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model.	CFH CFHR4	1.03e-05	3	65	2	20854881
Pubmed	TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing.	TET2 CTCF	1.03e-05	3	65	2	26711177
Pubmed	Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.	CFH CFHR4	1.03e-05	3	65	2	18202746
Pubmed	Blocking Properdin Prevents Complement-Mediated Hemolytic Uremic Syndrome and Systemic Thrombophilia.	CFH CFHR4	1.03e-05	3	65	2	29858280
Pubmed	Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration.	CFH CFHR4	1.03e-05	3	65	2	23747511
Pubmed	Isolation of cDNA for a novel human protein KNP-I that is homologous to the E. coli SCRP-27A protein from the autoimmune polyglandular disease type I (APECED) region of chromosome 21q22.3.	GATD3 TRAPPC10	1.03e-05	3	65	2	8753807
Pubmed	Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection.	CFH CFHR4	1.03e-05	3	65	2	17420242
Pubmed	Altered expression patterns of complement factor H and miR-146a genes in acute-chronic phases in experimental autoimmune encephalomyelitis mouse.	CFH CFHR4	1.03e-05	3	65	2	30972735
Pubmed	Retinal Basal Laminar Deposits in Complement fH/fP Mouse Model of Dense Deposit Disease.	CFH CFHR4	1.03e-05	3	65	2	30025090
Pubmed	Comparison of surface recognition and C3b binding properties of mouse and human complement factor H.	CFH CFHR4	1.03e-05	3	65	2	16023208
Pubmed	Location of theSas-1 locus on mouse chromosome 1.	CFH CFHR4	1.03e-05	3	65	2	21302086
Pubmed	Mesangial immune complex glomerulonephritis due to complement factor D deficiency.	CFH CFHR4	1.03e-05	3	65	2	17410102
Pubmed	An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region.	CTCF KCNQ1	1.03e-05	3	65	2	15340049
Pubmed	C3(H2O) prevents rescue of complement-mediated C3 glomerulopathy in Cfh-/- Cfd-/- mice.	CFH CFHR4	1.03e-05	3	65	2	32376801
Pubmed	VEGF regulates local inhibitory complement proteins in the eye and kidney.	CFH CFHR4	1.03e-05	3	65	2	27918307
Pubmed	Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes.	CFH CFHR4	1.03e-05	3	65	2	20702729
Pubmed	Changes in complement alternative pathway components, factor B and factor H during dengue virus infection in the AG129 mouse.	CFH CFHR4	1.03e-05	3	65	2	33410734
Pubmed	Incorporating prior knowledge to facilitate discoveries in a genome-wide association study on age-related macular degeneration.	CFH CFHR4	1.03e-05	3	65	2	20181037
Pubmed	Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.	CNKSR2 JMJD1C	1.03e-05	3	65	2	33591602
Pubmed	Complement factor H deficiency accelerates development of lupus nephritis.	CFH CFHR4	1.03e-05	3	65	2	21148254
Pubmed	Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy.	CFH CFHR4	1.03e-05	3	65	2	31409673
Pubmed	Two factor H-related proteins from the mouse: expression analysis and functional characterization.	CFH CFHR4	1.03e-05	3	65	2	17028856
Pubmed	Localization of complement factor H gene expression and protein distribution in the mouse outer retina.	CFH CFHR4	1.03e-05	3	65	2	25684976
Pubmed	Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes.	CFH CFHR4	1.03e-05	3	65	2	26768663
Interaction	HDAC1 interactions	TET2 FLNB SIN3B IKZF2 BBX CTCF ZNF273 NFE2L2 ZGRF1 JMJD1C MNT ZNF687 TRAK1 EFTUD2	7.68e-06	1108	64	14	int:HDAC1
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	CFAP52 RNLS ZNF273 KLHL32 HYDIN	6.96e-06	182	65	5	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFH COL15A1 IGFBP4 HMGCLL1 EPHA5	6.96e-06	182	65	5	0e52ba34e179d9bfaac7b49920b44c710b2b8dad
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 CNKSR2 NEB HYDIN EPHA5	7.33e-06	184	65	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 CNKSR2 NEB HYDIN EPHA5	7.33e-06	184	65	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 CNKSR2 NEB HYDIN EPHA5	7.33e-06	184	65	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP52 RNLS USP54 KLHL32 HYDIN	9.72e-06	195	65	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP52 RNLS USP54 KLHL32 HYDIN	9.72e-06	195	65	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ATP13A4 PLB1 ABCA3 RRP9 USP54	1.02e-05	197	65	5	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ATP13A4 ABCA3 RRP9 ALAS1 USP54	1.05e-05	198	65	5	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	ATP13A4 ABCA3 RRP9 ALAS1 USP54	1.10e-05	200	65	5	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	LPS_only-Epithelial_alveolar-AT_1\|LPS_only / Treatment groups by lineage, cell group, cell type	ATP13A4 ABCA3 RRP9 ALAS1 USP54	1.10e-05	200	65	5	9a6ae40f3e17cd44ee5fd73260713b920aa2ea15
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-5\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	ATP13A4 IKZF2 NFE2L2 C8orf74	5.85e-05	144	65	4	76c0e551864c4faab7528c4ecf1a40d7ea60569f
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CFAP52 CNKSR2 SLC24A1 SLC30A3	6.51e-05	148	65	4	223d6a640f3c34e73646a615593b9c0b4a4cbd6f
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 ABCA3 RRP9 USP54	7.41e-05	153	65	4	e7a074ea8232bacf924be78a244a8507c7e1ebc8
ToppCell	COVID-CD4-antiviral_CD4\|COVID / Condition, Cell_class and T cell subcluster	CFH IGFBP4 TLR9 SLC24A1	7.79e-05	155	65	4	7e5ae034036fe85915d38a24195501e6d3bcbfb0
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IKZF2 NUP210L FSD2 NEB	9.24e-05	162	65	4	adf545cf9357556e2ce7affed01c2f6a24b0581d
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CFH FSD2 PCDHA8 ADAMTS8	9.46e-05	163	65	4	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 IGFBP4 RRP9 ALAS1	9.92e-05	165	65	4	cca3ba9d7d30404e3e683b8cfd500c348a4974b9
ToppCell	facs-Heart-LA-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 FSD2 CNKSR2 KLHL32	1.02e-04	166	65	4	c43aec09578975df8984886993d15b42a10190c8
ToppCell	facs-Heart-LA-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 FSD2 CNKSR2 KLHL32	1.02e-04	166	65	4	829a8998ce68739a58202851afd73e049ab0f84f
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	SIN3B BBX FOXJ3 TRAK1	1.02e-04	166	65	4	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH RADIL COL15A1 HMGCLL1	1.14e-04	171	65	4	2a34685f7d83d1cf9a88d304173cbca868c5f9fd
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH RADIL VASH2 OVCH1	1.16e-04	172	65	4	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	MS-CD8-proli_CD4\|MS / Condition, Cell_class and T cell subcluster	ZNF567 FLNB TRAPPC10 USP54	1.16e-04	172	65	4	0b6dd257110b3f17fa71ab18a165b091a9d5ae9a
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF567 ZGRF1 HMGCLL1 ZNF730	1.19e-04	173	65	4	20889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF567 ZGRF1 HMGCLL1 ZNF730	1.19e-04	173	65	4	46e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	CFH PLB1 IGFBP4 PLXNA2	1.22e-04	174	65	4	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	IKZF2 CMIP NFE2L2 PLXNA2	1.24e-04	175	65	4	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH COL15A1 TNKS JMJD1C	1.27e-04	176	65	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	3'_v3-Lung-Myeloid_Monocytic-Cycling_mono\|Lung / Manually curated celltypes from each tissue	ZNF567 USP54 RFX8 MAP10	1.33e-04	178	65	4	67aa17b17da3121c199af45e747c23e2626a9bb2
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH COL15A1 IGFBP4 ADAMTS8	1.42e-04	181	65	4	269b39ac65790061d54eab47a8eeb024403f0348
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH COL15A1 IGFBP4 ADAMTS8	1.42e-04	181	65	4	cd4f744b6b64ba6c22ec07afd1d3058a2546909d
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH COL15A1 IGFBP4 ADAMTS8	1.42e-04	181	65	4	c8395ae872aa80b3ae1ab7c53e57b3ca15aeb0e2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH TGFBR2 FLNB GBP7	1.45e-04	182	65	4	ccc313ecc0bfd8e2c6bb83a565b427b2310485ec
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH TGFBR2 FLNB GBP7	1.45e-04	182	65	4	e6a734fb29105093d4cbfc3d0619a825b66da034
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH TGFBR2 FLNB GBP7	1.45e-04	182	65	4	b9f758961fb4a586ae86fa0b25edb8ce4616d644
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFE2L2 KCNQ1 ALAS1 TRAK1	1.48e-04	183	65	4	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	COVID-19-Epithelial_cells-ECM-high_epithelial\|COVID-19 / group, cell type (main and fine annotations)	FLNB ATP13A4 ABCA3 PLXNA2	1.48e-04	183	65	4	dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 ABCA3 RRP9 USP54	1.51e-04	184	65	4	42ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 ABCA3 RRP9 USP54	1.51e-04	184	65	4	7cc5796557379c3d1db078c1aeda40659c6e401c
ToppCell	5'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL15A1 IGFBP4 KCNQ1 KLHL32	1.51e-04	184	65	4	97e97de52daaff8840f4ee76a94ba5e3f79de7ce
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 ABCA3 RRP9 USP54	1.54e-04	185	65	4	0c247a3f394c42e2a6f67fee3d9cf33096fecd13
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT1-AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 ABCA3 RRP9 USP54	1.54e-04	185	65	4	68f428e169cfb77de970bdfdeea9b9f16f68d2ba
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	CFAP52 ZNF273 KLHL32 HYDIN	1.54e-04	185	65	4	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	BAL-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLNB IGFBP4 VASH2 TLR9	1.54e-04	185	65	4	f4588468e8654363f48adbe427dff10f16f1c7fe
ToppCell	Mesenchymal_cells-Osteo-CAR\|World / Lineage and Cell class	CFH PLB1 IGFBP4 PLXNA2	1.54e-04	185	65	4	16f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCell	BAL-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLNB IGFBP4 VASH2 TLR9	1.54e-04	185	65	4	3cb816fc9541c04b4436e21d984216cfbbacff98
ToppCell	BAL-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLNB IGFBP4 VASH2 TLR9	1.54e-04	185	65	4	c2e70405969616c28fb6379ee318e17bbcef7b49
ToppCell	BAL-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FLNB IGFBP4 VASH2 TLR9	1.57e-04	186	65	4	d2fbf53aac905c9896272ec5c2db28ee1a60f4be
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 ABCA3 RRP9 USP54	1.57e-04	186	65	4	e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCell	Mild-Lymphoid-pDC\|Mild / Condition, Lineage, Cell class and cell subclass	FLNB IGFBP4 VASH2 TLR9	1.57e-04	186	65	4	7fa82972c726025d6402e5eb7bf0db3b699eba4c
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 ABCA3 IKZF2 USP54	1.57e-04	186	65	4	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	Mild-Lymphoid-pDC-\|Mild / Condition, Lineage, Cell class and cell subclass	FLNB IGFBP4 VASH2 TLR9	1.57e-04	186	65	4	1d05e73ae2ec0cc27f79e4fa40d6b21790059f80
ToppCell	BAL-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLNB IGFBP4 VASH2 TLR9	1.57e-04	186	65	4	79aedd5aed72509a4925e9f6cb43bc0c798c86f5
ToppCell	BAL-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FLNB IGFBP4 VASH2 TLR9	1.57e-04	186	65	4	b031f4e6867b6200b85f43276a34749bf5f4603f
ToppCell	LPS_only-Epithelial_alveolar-AT_1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 ABCA3 RRP9 USP54	1.60e-04	187	65	4	ff26a533d310126521efe1d05cf8b9d32e524550
ToppCell	Mild_COVID-19-Myeloid-pDC\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FLNB IGFBP4 VASH2 TLR9	1.60e-04	187	65	4	99c3c4a7b9179dce7982dc6516d561c952abc80e
ToppCell	LPS-antiTNF-Epithelial_alveolar\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 ABCA3 RRP9 USP54	1.60e-04	187	65	4	201ff693e4756ee3e44762885b3a303a77eb535b
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 ABCA3 RRP9 USP54	1.64e-04	188	65	4	43a0508d2524a5b310e89e9422843dcaab999bc3
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	CFH FLNB CMIP PLXNA2	1.67e-04	189	65	4	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP52 RNLS KLHL32 HYDIN	1.67e-04	189	65	4	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR2 RADIL SLC24A1 SLC30A3	1.71e-04	190	65	4	b2bd2cb384bb8a5662064ed1aee68e905e1f780d
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR2 RADIL SLC24A1 SLC30A3	1.71e-04	190	65	4	32400c62cb9de4c2b24af4206c21a0215ab12212
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH IGFBP4 ADAMTS8 EPHA5	1.71e-04	190	65	4	97772e69e6f51ebffbb5433ca7b40f1048723220
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH COL15A1 CNKSR2 HMGCLL1	1.71e-04	190	65	4	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	droplet-Lung-nan-18m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH IGFBP4 ADAMTS8 EPHA5	1.71e-04	190	65	4	72c2b824acdc43139e6635785df3ed3feb58ec46
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP52 RNLS KLHL32 HYDIN	1.74e-04	191	65	4	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 ABCA3 USP54 PLXNA2	1.74e-04	191	65	4	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP52 RNLS KLHL32 HYDIN	1.74e-04	191	65	4	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP52 RNLS KLHL32 HYDIN	1.74e-04	191	65	4	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFBR2 RADIL IGFBP4 SLC24A1	1.78e-04	192	65	4	291df12b4b5ff11fbaa43033692b8f4b5cdf65a1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH COL15A1 CNKSR2 HMGCLL1	1.78e-04	192	65	4	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFBR2 RADIL IGFBP4 SLC24A1	1.78e-04	192	65	4	35ffe7aa9ffab85eac3326651e901c39d0119650
ToppCell	IPF-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	CFAP52 RNLS KLHL32 HYDIN	1.78e-04	192	65	4	d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCell	COPD-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	CFAP52 RNLS KLHL32 HYDIN	1.78e-04	192	65	4	eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	CFAP52 RNLS KLHL32 HYDIN	1.78e-04	192	65	4	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	CFH FLNB CMIP PLXNA2	1.81e-04	193	65	4	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP52 RNLS KLHL32 HYDIN	1.81e-04	193	65	4	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 CFAP52 USP54 HYDIN	1.81e-04	193	65	4	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFBR2 RADIL IGFBP4 SLC24A1	1.81e-04	193	65	4	040f6bb42aa41d0921371fdda1cc0912c4fe1930
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP52 RNLS KLHL32 HYDIN	1.81e-04	193	65	4	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFBR2 RADIL IGFBP4 SLC24A1	1.81e-04	193	65	4	e468287c8b30c56d1de65e8347ade233ba6cf584
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFH COL15A1 IGFBP4 PLXNA2	1.88e-04	195	65	4	4658fb197657d7692ee344ae76b11b0210c418ba
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	CFAP52 RNLS KLHL32 HYDIN	1.88e-04	195	65	4	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH COL15A1 ADAMTS8 HMGCLL1	1.92e-04	196	65	4	42e9828222a9663525d571633e8a454c30bfa7f8
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	CFAP52 USP54 KLHL32 HYDIN	1.92e-04	196	65	4	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	ABCA3 RRP9 ALAS1 USP54	1.96e-04	197	65	4	1a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	ABCA3 RRP9 VASH2 PLXNA2	1.96e-04	197	65	4	6b6504c47c309bac4f790e2f372d454bbdea49e8
ToppCell	distal-Endothelial-Bronchial_Vessel_1-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TGFBR2 CMIP COL15A1 IGFBP4	1.96e-04	197	65	4	0d1afd1ad7489c071db08b3dfff598423097d7e0
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ABCA3 RRP9 ALAS1 USP54	1.96e-04	197	65	4	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ABCA3 RRP9 ALAS1 USP54	2.00e-04	198	65	4	aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	COL15A1 CNKSR2 ADAMTS8 ZNF687	2.00e-04	198	65	4	cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / Treatment groups by lineage, cell group, cell type	ABCA3 RRP9 ALAS1 USP54	2.00e-04	198	65	4	655df75b9692d815c7f6910275e1f684ac63bf62
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH COL15A1 ADAMTS8 NEB	2.00e-04	198	65	4	55e583321f60c95898d93cd0d2615c6692db52ec
ToppCell	facs-Trachea-nan-3m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH TGFBR2 COL15A1 IGFBP4	2.00e-04	198	65	4	0dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCell	Biopsy_Other_PF-Endothelial-Lymphatic_Endothelial_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	RADIL IGFBP4 SLC24A1 SLC30A3	2.04e-04	199	65	4	aa80c77fe4f6a141c780c7d8ecfff5d5a1c3b845
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH COL15A1 ADAMTS8 NEB	2.04e-04	199	65	4	e19b296d583f8bad3b66ee998a8153634d6fe09e
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH COL15A1 ADAMTS8 NEB	2.04e-04	199	65	4	801887db51ac5dc5b068808ff75e3a46643398e9
ToppCell	ILEUM-inflamed-(8)_Fibroblast-(8)_Fibroblasts\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CFH FLNB CMIP COL15A1	2.04e-04	199	65	4	615f20bf136dfef53b072667cf0e4df6a1017e05
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast-(8)_Fibroblasts\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CFH FLNB COL15A1 IGFBP4	2.04e-04	199	65	4	56d72da6a5fab9cbb2975fe6f87a631debaba6a8
Disease	c3d:C3 ratio	CFH CFHR4	4.63e-06	2	64	2	EFO_0008543
Disease	ephrin type-a receptor 5 measurement	CFH EPHA5	1.39e-05	3	64	2	EFO_0020353
Disease	calnexin measurement	CFH CFHR4	1.39e-05	3	64	2	EFO_0801444
Disease	complement factor H-related protein 4A measurement	CFH CFHR4	1.39e-05	3	64	2	EFO_0600057
Disease	histone-lysine N-methyltransferase 2D measurement	CFH CFHR4	1.39e-05	3	64	2	EFO_0801683
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFH CFHR4	2.77e-05	4	64	2	EFO_0803292
Disease	kallikrein-5 measurement	CFH CFHR4	2.77e-05	4	64	2	EFO_0020515
Disease	tumor necrosis factor ligand superfamily member 18 measurement	CFH KCNQ1	6.91e-05	6	64	2	EFO_0020795
Disease	complement C1s subcomponent measurement	CFH CFHR4	6.91e-05	6	64	2	EFO_0008091
Disease	Atypical hemolytic-uremic syndrome	CFH CFHR4	1.65e-04	9	64	2	cv:C2931788
Disease	Hemolytic-uremic syndrome	CFH CFHR4	1.65e-04	9	64	2	cv:C0019061
Disease	leukocyte immunoglobulin-like receptor subfamily A member 5 measurement	CFH CFHR4	1.65e-04	9	64	2	EFO_0801766
Disease	complement factor H-related protein 4 measurement	CFH CNKSR2 CFHR4	1.67e-04	49	64	3	EFO_0600091
Disease	neutrophil count	TET2 FLNB CMIP BBX NUP210L SBF2 VASH2 PCDHA8 PCDHA6 JMJD1C HYDIN	1.73e-04	1382	64	11	EFO_0004833
Disease	pulse pressure measurement	CFH TET2 FLNB COL15A1 NFE2L2 SBF2 PCDHA8 PCDHA6 ADAMTS8 HYDIN TRAK1	1.84e-04	1392	64	11	EFO_0005763
Disease	response to carboplatin, response to antineoplastic agent	FLNB CMIP	2.06e-04	10	64	2	GO_0097327, GO_0097328
Disease	membranoproliferative glomerulonephritis (implicated_via_orthology)	CFH TGFBR2	2.06e-04	10	64	2	DOID:2920 (implicated_via_orthology)
Disease	gastrin-releasing peptide measurement	CFH JMJD1C	2.52e-04	11	64	2	EFO_0022000
Disease	hemopexin measurement	CFH CFHR4	2.52e-04	11	64	2	EFO_0008149
Disease	Pathological accumulation of air in tissues	ABCA3 NFE2L2	3.01e-04	12	64	2	C0013990
Disease	vascular endothelial growth factor A measurement	CFH JMJD1C	3.01e-04	12	64	2	EFO_0010804
Disease	total blood protein measurement	CFH BBX RNLS SBF2 RFX8 HYDIN	4.27e-04	449	64	6	EFO_0004536
Disease	pulse pressure measurement, alcohol drinking	TNKS ADAMTS8 TRAK1	4.80e-04	70	64	3	EFO_0004329, EFO_0005763
Disease	hepatocellular carcinoma (is_implicated_in)	TET2 NFE2L2 TLR9 EFTUD2	6.53e-04	181	64	4	DOID:684 (is_implicated_in)
Disease	lupus nephritis (is_implicated_in)	CFH TLR9	6.93e-04	18	64	2	DOID:0080162 (is_implicated_in)
Disease	squamous cell carcinoma (is_marker_for)	CFH TLR9	7.73e-04	19	64	2	DOID:1749 (is_marker_for)
Disease	coagulation factor measurement	CFH CFHR4	8.58e-04	20	64	2	EFO_0004634
Disease	visceral adipose tissue measurement, body mass index	PCDHA8 PCDHA6 CNKSR2	9.06e-04	87	64	3	EFO_0004340, EFO_0004765
Disease	cardiovascular system disease (is_implicated_in)	CFH TLR9	9.47e-04	21	64	2	DOID:1287 (is_implicated_in)
Disease	eosinophil percentage of leukocytes	PLB1 IKZF2 CMIP CTCF SBF2 PCDHA6 JMJD1C	1.14e-03	746	64	7	EFO_0007991
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	CMIP TNKS JMJD1C	1.17e-03	95	64	3	EFO_0004529, EFO_0008317, EFO_0008596
Disease	chylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement	CMIP TNKS JMJD1C	1.20e-03	96	64	3	EFO_0004530, EFO_0008317, EFO_0008596
Disease	FEV/FEC ratio	TET2 ABCA3 COL15A1 RNLS CTCF SBF2 CNKSR2 NEB JMJD1C	1.28e-03	1228	64	9	EFO_0004713
Disease	neuroticism measurement, cognitive function measurement	TET2 BBX NUP210L PCDHA8 PCDHA6 JMJD1C	1.42e-03	566	64	6	EFO_0007660, EFO_0008354
Disease	neutrophil count, basophil count	TET2 PCDHA8 PCDHA6 JMJD1C	1.44e-03	224	64	4	EFO_0004833, EFO_0005090
Disease	L lactate dehydrogenase measurement	CFH KCNQ1	1.46e-03	26	64	2	EFO_0004808
Disease	sleep duration, triglyceride measurement	ZNF273 TNKS JMJD1C	1.52e-03	104	64	3	EFO_0004530, EFO_0005271
Disease	macular degeneration (is_implicated_in)	CFH NFE2L2	1.57e-03	27	64	2	DOID:4448 (is_implicated_in)
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement	CMIP TNKS JMJD1C	1.60e-03	106	64	3	EFO_0008317, EFO_0008596
Disease	chronic kidney disease (biomarker_via_orthology)	RNLS NFE2L2	1.69e-03	28	64	2	DOID:784 (biomarker_via_orthology)
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipid measurement	CMIP TNKS JMJD1C	1.73e-03	109	64	3	EFO_0004639, EFO_0008317, EFO_0008596
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	CMIP TNKS JMJD1C	1.78e-03	110	64	3	EFO_0008317, EFO_0008596, EFO_0010351
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	CMIP TNKS JMJD1C	1.78e-03	110	64	3	EFO_0008317, EFO_0008591, EFO_0008596
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	CMIP TNKS JMJD1C	1.78e-03	110	64	3	EFO_0004574, EFO_0008317, EFO_0008596
Disease	complement factor H-related protein 2 measurement	CFH CFHR4	1.81e-03	29	64	2	EFO_0600055
Disease	1,5 anhydroglucitol measurement	PCDHA8 PCDHA6	1.81e-03	29	64	2	EFO_0008009
Disease	type 1 diabetes mellitus	GATD3 PLB1 RNLS KCNQ1	1.91e-03	242	64	4	MONDO_0005147
Disease	Age related macular degeneration	CFH CFHR4	1.94e-03	30	64	2	C0242383

Protein segments in the cluster

Peptide	Gene	Start	Entry
DLTVAHLEVCMPPHP	C8orf74	136	Q6P047
DVPSRKDHMCHPHGI	BBX	421	Q8WY36
HTGTRPHKCPDCDMA	CTCF	316	P49711
GVPAHAMVVKPCRTA	ATP13A4	571	Q4VNC1
GHVLSMPHDDSKPCT	ADAMTS8	366	Q9UP79
SVTDEPPKMHCSAEG	EPHA5	266	P54756
KFIQSMHGPTGHCPH	CMIP	306	Q8IY22
AGYHMTLVKEPHCNP	ABCA3	756	Q99758
CKSPPEISHGVVAHM	CFH	931	P08603
DATDKGHPPMAGHCT	PCDHA6	321	Q9UN73
GHPPMAGHCTVLVRI	PCDHA6	326	Q9UN73
ASQPVCPEGMHHVVL	RADIL	826	Q96JH8
DATDKGHPPMAGHCT	PCDHA8	321	Q9Y5H6
GHPPMAGHCTVLVRI	PCDHA8	326	Q9Y5H6
VTPGEKMLTVPHITC	KCNQ1	431	P51787
CLKHPSSAAHEHPPM	MAP10	351	Q9P2G4
VHHCVVVKPTPAMLT	SLC24A1	391	O60721
MDAGLPVVHCPSHII	ALAS1	516	P13196
GVTQDHIKSLHCMIP	SBF2	831	Q86WG5
CVKGQPHDHKHLMPT	JMJD1C	1891	Q15652
CHPNKMIHDTGIPAE	KIAA1109	611	Q2LD37
APDVPQMHVIDHTKG	GATD3B	81	A0A0B4J2D5
VPTGLKCHPDQEHMI	CFAP52	26	Q8N1V2
DPVPLSIHHMPICVS	EXOSC9	181	Q06265
GPTTPCEEVSMKHVG	FLNB	2551	O75369
CEPPNLTGQHKVMVH	PLXNA2	1201	O75051
AVFHMPSPDACHKAL	OR52B4	226	Q8NGK2
SIPSMEKEVGNCSPH	NFE2L2	231	Q16236
VMAKPAVGAQVVHHP	MNT	541	Q99583
HMPGPVCLTENTKGH	GBP7	6	Q8N8V2
GQVMSHHVPPMEDCK	IKZF2	231	Q9UKS7
PQMGHLHPGCAKDIV	HYDIN	3696	Q4G0P3
NVCHGAMHPTKPSQH	FOXJ3	531	Q9UPW0
ISMKPCEFPEIQHGH	CFHR4	266	Q92496
APDVPQMHVIDHTKG	GATD3	81	P0DPI2
VRPHCKMPVDTAHPG	COL15A1	961	P39059
PGPMHCSSTHIAAKS	NUP210L	611	Q5VU65
LVSHIPKQMSTPCHP	PRR14L	1586	Q5THK1
LMNECIGHVIGKPHS	MAP3K4	1121	Q9Y6R4
VMKEIPPGALAVHCH	HMGCLL1	266	Q8TB92
FPMKPTTFVCHGHLR	OVCH1	1026	Q7RTY7
PGCLKVHNGISMPKH	FSD2	731	A1L4K1
MVPCKTLCETVHVHG	SIN3B	1131	O75182
LHSDHTPCGRPKMPI	TGFBR2	361	P37173
PKHMEVGGCTFIHPD	SPATA31E1	346	Q6ZUB1
VEKPLHTLMHGQGVC	IGFBP4	86	P22692
VPMPVCHTGKRVIPH	PLB1	121	Q6P1J6
PCEDLRGHMVGKPVH	CNKSR2	371	Q8WXI2
PETSAHHPGKCMSQT	TRAK1	651	Q9UPV9
HLISVGCHMTKPDVI	ZNF567	41	Q8N184
HAMVAKPPVVCSHFA	ZNF273	101	Q14593
FPGHVMKVPRENHCS	ZC3H6	556	P61129
VGLSPMHFPCHMTIE	TLR9	101	Q9NR96
AEGKPPGHSSHVLCM	RRP9	191	O43818
PGQMTLHHKPFLACG	RNLS	301	Q5VYX0
ATCEDHSPMKTDPVG	RFX8	136	Q6ZV50
CHGKSAVDMAPTPEL	TNKS	466	O95271
MTGSAADTHRCPHPK	VASH2	1	Q86V25
KTHDMVAKPPVICSH	ZNF730	66	Q6ZMV8
LPEESKPVEMPFHHC	SLC30A3	41	Q99726
TGPGLAIHCMQVHKE	ZNF207	46	O43670
VPSCHHSQPAKLVMV	ZGRF1	1346	Q86YA3
ICPMAFKSGPSAHAH	ZNF687	796	Q8N1G0
HSACSSEHKGLPMPR	TRAPPC10	1211	P48553
VDMCVQHIPSPKVGA	EFTUD2	431	Q15029
IKVEPGCKPHACMHT	TET2	981	Q6N021
TCHPIMPVASSFVLH	USP54	1071	Q70EL1
PMPVGRSHHCVAVMG	KLHL32	331	Q96NJ5
HVKERGTCHAVPDTP	NEB	5621	P20929