Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsyntaxin-1 binding

UNC13B DAPK1 SYT1 UNC13C

7.91e-06241084GO:0017075
GeneOntologyMolecularFunctionphorbol ester receptor activity

UNC13B UNC13C

2.90e-0521082GO:0001565
GeneOntologyMolecularFunctionnon-kinase phorbol ester receptor activity

UNC13B UNC13C

2.90e-0521082GO:0001566
GeneOntologyMolecularFunctioncytoskeletal protein binding

CACNB2 MYH11 MID2 GIT1 NEIL2 SPTA1 SPTB CAPN3 ARPC2 SPTBN5 S100A8 LLGL2 MACO1 KCNMA1 DIXDC1 FERMT2 MLPH

8.26e-05109910817GO:0008092
GeneOntologyMolecularFunction11-cis-retinol dehydrogenase activity

RDH12 RDH11

8.66e-0531082GO:0102354
GeneOntologyMolecularFunctionactin filament binding

CACNB2 MYH11 SPTA1 SPTB ARPC2 SPTBN5 FERMT2

2.36e-042271087GO:0051015
GeneOntologyMolecularFunctionactin binding

CACNB2 MYH11 SPTA1 SPTB ARPC2 SPTBN5 KCNMA1 DIXDC1 FERMT2 MLPH

2.73e-0447910810GO:0003779
GeneOntologyMolecularFunctioncalcium ion sensor activity

EFHB SYT1

5.98e-0471082GO:0061891
GeneOntologyMolecularFunctioncAMP-dependent protein kinase activity

PRKX PRKY

5.98e-0471082GO:0004691
GeneOntologyMolecularFunctionphospholipid binding

UNC13B GGA2 APOB ZFYVE1 GGA3 SYT1 UNC13C FERMT2 GGA1 RPE65

7.79e-0454810810GO:0005543
GeneOntologyMolecularFunctionmetal ion sensor activity

EFHB SYT1

7.94e-0481082GO:0140784
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor binding

APOB SACS SYT1

8.15e-04341083GO:0050750
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

GPD2 RDH12 IDH1 FASN RDH11

9.24e-041381085GO:0016614
GeneOntologyMolecularFunctioncyclic nucleotide-dependent protein kinase activity

PRKX PRKY

1.02e-0391082GO:0004690
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNB2 RIMBP2

1.02e-0391082GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNB2 RIMBP2

1.02e-0391082GO:0099626
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

APOB SACS SYT1

1.22e-03391083GO:0070325
GeneOntologyMolecularFunctionsyntaxin binding

UNC13B DAPK1 SYT1 UNC13C

1.28e-03871084GO:0019905
GeneOntologyMolecularFunctionstructural constituent of synapse

GIT1 SHANK2 RIMBP2

1.52e-03421083GO:0098918
GeneOntologyMolecularFunctionsmall GTPase binding

UNC13B GGA2 GIT1 CDC42BPB GGA3 GGA1 MLPH

1.81e-033211087GO:0031267
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNB2 RIMBP2 CACNA2D3

1.97e-03461083GO:0005245
GeneOntologyMolecularFunctionstructural constituent of postsynaptic specialization

GIT1 SHANK2

2.17e-03131082GO:0098879
GeneOntologyMolecularFunctionmagnesium ion binding

ATP8B3 IDH1 CDC42BPB ADCY2 PRIM1 TSSK1B

2.26e-032471086GO:0000287
GeneOntologyBiologicalProcessestablishment or maintenance of polarity of embryonic epithelium

WNT7B PALS1 LLGL2

1.25e-0731043GO:0016332
GeneOntologyCellularComponentneuron projection terminus

UNC13B GIT1 ARPC2 MACO1 KCNMA1 SYT1 RIMBP2 UNC13C DIXDC1 AP3D1

3.33e-0723310710GO:0044306
GeneOntologyCellularComponentspectrin

SPTA1 SPTB SPTBN5

1.07e-0591073GO:0008091
GeneOntologyCellularComponentaxon terminus

UNC13B GIT1 ARPC2 KCNMA1 RIMBP2 UNC13C DIXDC1 AP3D1

1.26e-052101078GO:0043679
GeneOntologyCellularComponentcell cortex

UNC13B SPTA1 SPTB SPTBN5 LLGL2 RIMBP2 UNC13C FERMT2 GPSM1 MLPH

2.10e-0537110710GO:0005938
GeneOntologyCellularComponentcalyx of Held

UNC13B GIT1 RIMBP2 UNC13C

3.37e-05361074GO:0044305
GeneOntologyCellularComponentcell cortex region

UNC13B SPTBN5 RIMBP2 UNC13C

8.22e-05451074GO:0099738
GeneOntologyCellularComponentpresynaptic active zone

UNC13B SHANK2 KCNMA1 RIMBP2 UNC13C CACNA2D3

8.75e-051411076GO:0048786
GeneOntologyCellularComponentcortical actin cytoskeleton

SPTA1 SPTB SPTBN5 LLGL2 MLPH

1.16e-04931075GO:0030864
GeneOntologyCellularComponentactin cytoskeleton

MYH11 SPTA1 SPTB DAPK1 CDC42BPB ARPC2 SPTBN5 LLGL2 DIXDC1 FERMT2 MLPH

1.79e-0457610711GO:0015629
GeneOntologyCellularComponentaxon

UNC13B GIT1 SPTA1 ARPC2 PALS1 SHANK2 SACS MACO1 KCNMA1 SYT1 RIMBP2 UNC13C DIXDC1 AP3D1

1.80e-0489110714GO:0030424
GeneOntologyCellularComponentpresynaptic active zone cytoplasmic component

UNC13B RIMBP2 UNC13C

2.14e-04231073GO:0098831
GeneOntologyCellularComponentglutamatergic synapse

UNC13B GIT1 SPTB DAPK1 GPC6 SLC1A6 ARPC2 SHANK2 KCNMA1 SYT1 RIMBP2 DIXDC1 AP3D1

2.76e-0481710713GO:0098978
GeneOntologyCellularComponentactomyosin

MYH11 CDC42BPB DIXDC1 FERMT2 MLPH

3.40e-041171075GO:0042641
GeneOntologyCellularComponentATP-binding cassette (ABC) transporter complex

ABCA2 ABCD4

3.84e-0461072GO:0043190
GeneOntologyCellularComponentdistal axon

UNC13B GIT1 ARPC2 SHANK2 KCNMA1 RIMBP2 UNC13C DIXDC1 AP3D1

4.00e-044351079GO:0150034
GeneOntologyCellularComponentcortical cytoskeleton

SPTA1 SPTB SPTBN5 LLGL2 MLPH

5.32e-041291075GO:0030863
GeneOntologyCellularComponentpresynapse

UNC13B CACNB2 GIT1 SLC1A6 ARPC2 SHANK2 KCNMA1 SYT1 RIMBP2 UNC13C DIXDC1 AP3D1 CACNA2D3

5.95e-0488610713GO:0098793
GeneOntologyCellularComponentphotoreceptor cell cilium

SPTBN5 EYS SHANK2 RDH11 IFT122

7.47e-041391075GO:0097733
GeneOntologyCellularComponentspectrin-associated cytoskeleton

SPTA1 SPTB

9.13e-0491072GO:0014731
GeneOntologyCellularComponent9+0 non-motile cilium

SPTBN5 EYS SHANK2 RDH11 IFT122

1.15e-031531075GO:0097731
GeneOntologyCellularComponentterminal bouton

UNC13B KCNMA1 UNC13C AP3D1

1.50e-03961074GO:0043195
GeneOntologyCellularComponentGolgi apparatus subcompartment

ATP8B3 UXS1 GGA2 ZFYVE1 GGA3 COG6 GGA1 AP3D1

2.00e-034431078GO:0098791
GeneOntologyCellularComponentcontractile actin filament bundle

MYH11 DIXDC1 FERMT2 MLPH

2.24e-031071074GO:0097517
GeneOntologyCellularComponentexcitatory synapse

GIT1 SLC1A6 SYT1 UNC13C

2.24e-031071074GO:0060076
GeneOntologyCellularComponentstress fiber

MYH11 DIXDC1 FERMT2 MLPH

2.24e-031071074GO:0001725
GeneOntologyCellularComponentGolgi lumen

WNT7B GPC6 F8 BGN

2.39e-031091074GO:0005796
GeneOntologyCellularComponentphotoreceptor outer segment

SPTBN5 EYS SHANK2 RDH11

2.55e-031111074GO:0001750
GeneOntologyCellularComponentcytoplasmic vesicle membrane

UNC13B ATP8B3 LPCAT1 ABCA2 GGA2 WNT7B APOB GGA3 ARPC2 SERPINB12 SYT1 UNC13C KIR2DL3 GGA1 AP3D1

2.67e-03130710715GO:0030659
GeneOntologyCellularComponentmelanosome

MYH11 PDIA4 FASN MLPH

2.72e-031131074GO:0042470
GeneOntologyCellularComponentpigment granule

MYH11 PDIA4 FASN MLPH

2.72e-031131074GO:0048770
GeneOntologyCellularComponentpresynaptic membrane

UNC13B SLC1A6 KCNMA1 SYT1 UNC13C CACNA2D3

3.03e-032771076GO:0042734
GeneOntologyCellularComponentvesicle membrane

UNC13B ATP8B3 LPCAT1 ABCA2 GGA2 WNT7B APOB GGA3 ARPC2 SERPINB12 SYT1 UNC13C KIR2DL3 GGA1 AP3D1

3.04e-03132510715GO:0012506
GeneOntologyCellularComponentactin filament bundle

MYH11 DIXDC1 FERMT2 MLPH

3.18e-031181074GO:0032432
GeneOntologyCellularComponentnon-motile cilium

SPTBN5 EYS SHANK2 RDH11 IFT122

3.38e-031961075GO:0097730
GeneOntologyCellularComponenttrans-Golgi network

ATP8B3 GGA2 GGA3 COG6 GGA1 AP3D1

4.92e-033061076GO:0005802
GeneOntologyCellularComponenthippocampal mossy fiber to CA3 synapse

UNC13B SHANK2 SYT1

4.93e-03671073GO:0098686
MousePhenodelayed dark adaptation

RDH12 RDH11 RPE65

3.10e-0510913MP:0003011
MousePhenocerebral infarct

SPTA1 SPTB

4.19e-052912MP:0021003
MousePhenolow mean erythrocyte cell number

RB1 SPTA1 SPTB

5.63e-0512913MP:0002594
DomainGAE

GGA2 GGA3 GGA1

1.76e-0651063PS50180
Domain-

GGA2 GGA3 GGA1

3.51e-06610632.60.40.1230
DomainGAT_dom

GGA2 GGA3 GGA1

3.51e-0661063IPR004152
Domain-

GGA2 GGA3 GGA1

3.51e-06610631.20.58.160
DomainClathrin_g-adaptin_app

GGA2 GGA3 GGA1

3.51e-0661063IPR008153
DomainGAT

GGA2 GGA3 GGA1

3.51e-0661063PS50909
DomainGAT

GGA2 GGA3 GGA1

3.51e-0661063PF03127
DomainAlpha_adaptinC2

GGA2 GGA3 GGA1

1.46e-0591063PF02883
DomainVHS

GGA2 GGA3 GGA1

1.46e-0591063PS50179
DomainClathrin_a/b/g-adaptin_app_Ig

GGA2 GGA3 GGA1

1.46e-0591063IPR008152
DomainVHS

GGA2 GGA3 GGA1

1.46e-0591063PF00790
DomainAlpha_adaptinC2

GGA2 GGA3 GGA1

1.46e-0591063SM00809
DomainVHS

GGA2 GGA3 GGA1

1.46e-0591063SM00288
DomainVHS_dom

GGA2 GGA3 GGA1

1.46e-0591063IPR002014
DomainSPEC

SPTA1 SPTB MCF2L2 SPTBN5

3.12e-05321064SM00150
DomainSpectrin/alpha-actinin

SPTA1 SPTB MCF2L2 SPTBN5

3.12e-05321064IPR018159
DomainCoatomer/clathrin_app_Ig-like

GGA2 GGA3 GGA1

3.77e-05121063IPR013041
DomainUnc-13

UNC13B UNC13C

9.54e-0531062IPR027080
DomainSpectrin

SPTA1 SPTB SPTBN5

2.90e-04231063PF00435
DomainMunc13_dom-2

UNC13B UNC13C

3.16e-0451062IPR014772
DomainMHD2

UNC13B UNC13C

3.16e-0451062PS51259
DomainMunc13_subgr_dom-2

UNC13B UNC13C

3.16e-0451062IPR019558
DomainMembr_traf_MHD

UNC13B UNC13C

3.16e-0451062PF10540
DomainDUF1041

UNC13B UNC13C

3.16e-0451062SM01145
Domain-

GGA2 GGA3 GGA1

4.20e-042610631.25.40.90
DomainENTH_VHS

GGA2 GGA3 GGA1

5.83e-04291063IPR008942
DomainSpectrin_repeat

SPTA1 SPTB SPTBN5

5.83e-04291063IPR002017
DomainMunc13_1

UNC13B UNC13C

6.58e-0471062IPR014770
DomainMHD1

UNC13B UNC13C

6.58e-0471062PS51258
DomainDUF1041

UNC13B UNC13C

6.58e-0471062PF06292
DomainCAPS_dom

UNC13B UNC13C

6.58e-0471062IPR010439
DomainEF_HAND_2

GPD2 LPCAT1 SPTA1 CAPN3 EFHB S100A8

2.05e-032311066PS50222
DomainEFh

GPD2 LPCAT1 SPTA1 CAPN3 EFHB

2.07e-031581065SM00054
DomainEF_hand_dom

GPD2 LPCAT1 SPTA1 CAPN3 EFHB S100A8

2.09e-032321066IPR002048
Domain-

UXS1 RDH12 FASN RDH11 KCNMA1

2.78e-0316910653.40.50.720
DomainNAD(P)-bd_dom

UXS1 RDH12 FASN RDH11 KCNMA1

3.07e-031731065IPR016040
DomainP-loop_NTPase

CACNB2 ABCA2 MYH11 NLRP7 DAPK1 ZFYVE1 DDX10 DMC1 PALS1 NLRP10 SULT6B1 ABCD4

3.11e-0384810612IPR027417
Domain-

GPD2 LPCAT1 SPTA1 CAPN3 EFHB S100A8

3.74e-0326110661.10.238.10
Domainadh_short

RDH12 FASN RDH11

3.76e-03551063PF00106
DomainC1_1

UNC13B CDC42BPB UNC13C

4.16e-03571063PF00130
DomainPH

MCF2L2 STAP2 CDC42BPB PLEKHG4B SPTBN5 FERMT2

5.08e-032781066SM00233
DomainPH_DOMAIN

MCF2L2 STAP2 CDC42BPB PLEKHG4B SPTBN5 FERMT2

5.17e-032791066PS50003
DomainPH_domain

MCF2L2 STAP2 CDC42BPB PLEKHG4B SPTBN5 FERMT2

5.26e-032801066IPR001849
Domain-

SACS TOP2B

5.67e-032010623.30.565.10
PathwayREACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

PANK3 SHMT1 APOB IDH1 GPC6 FASN RDH11 ABCD4

2.32e-05189888MM14772
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTA1 SPTB SPTBN5

2.73e-0510883MM15112
PathwayREACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

PANK3 SHMT1 APOB IDH1 GPC6 FASN RDH11 ABCD4

3.23e-05198888M18311
PathwayREACTOME_NEURONAL_SYSTEM

UNC13B CACNB2 GIT1 ADCY2 SLC1A6 SHANK2 KCNMA1 SYT1 PRKX CACNA2D3

2.36e-044118810M735
PathwayREACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION

RDH12 RDH11 RPE65

2.48e-0420883MM14888
PathwayREACTOME_VISUAL_PHOTOTRANSDUCTION

RDH12 APOB GPC6 RDH11 RPE65

2.71e-0492885MM14881
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

UNC13B CACNB2 GIT1 ADCY2 SLC1A6 SYT1 PRKX CACNA2D3

2.79e-04270888M15514
PathwayREACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION

RDH12 RDH11 RPE65

3.80e-0423883M27174
PathwayREACTOME_VISUAL_PHOTOTRANSDUCTION

RDH12 APOB GPC6 RDH11 RPE65

3.99e-04100885M27158
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SLC1A6 SYT1

4.33e-0424883MM14834
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SLC1A6 SYT1

4.33e-0424883M630
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

GPD2 CACNB2 MYH11 GIT1 SPTA1 SPTB DAPK1 CDC42BPB ARPC2 TARS3 FASN SHANK2 SACS UGP2 SYT1 RIMBP2 ALB FERMT2 AP3D1 CACNA2D3

1.57e-0814311082037142655
Pubmed

Mammalian GGAs act together to sort mannose 6-phosphate receptors.

GGA2 GGA3 GGA1

2.91e-083108314638859
Pubmed

Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor.

GGA2 GGA3 GGA1

2.91e-083108318638397
Pubmed

Defects in cellular sorting and retroviral assembly induced by GGA overexpression.

GGA2 GGA3 GGA1

2.91e-083108319788741
Pubmed

Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting.

GGA2 GGA3 GGA1

2.91e-083108333206455
Pubmed

Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.

GGA2 GGA3 GGA1

1.16e-074108327901063
Pubmed

Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors.

GGA2 GGA3 GGA1

1.16e-074108315345724
Pubmed

PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal.

GGA2 GGA3 GGA1

1.16e-074108317494868
Pubmed

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.

GGA2 GGA3 GGA1

1.16e-074108310747089
Pubmed

A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi.

GGA2 GGA3 GGA1

1.16e-074108310749927
Pubmed

Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress.

RDH12 RDH11 RPE65

1.16e-074108318326732
Pubmed

Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes.

SPTA1 SPTB IDH1

1.16e-07410836234993
Pubmed

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

GGA2 GGA3 GGA1

1.16e-074108315615712
Pubmed

Analysis of the interaction between GGA1 GAT domain and Rabaptin-5.

GGA2 GGA3 GGA1

1.16e-074108316473621
Pubmed

The GGAs promote ARF-dependent recruitment of clathrin to the TGN.

GGA2 GGA3 GGA1

2.90e-075108311301005
Pubmed

GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.

GGA2 GGA3 GGA1

2.90e-075108326446845
Pubmed

RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch.

GGA2 GGA3 GGA1

2.90e-075108325195858
Pubmed

Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.

GGA2 GGA3 GGA1

2.90e-075108314567678
Pubmed

Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains.

GGA2 GGA3 GGA1

2.90e-075108311859375
Pubmed

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).

GGA2 GGA3 GGA1

2.90e-075108326053850
Pubmed

Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.

GGA2 GGA3 GGA1

2.90e-075108324407285
Pubmed

Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development.

GGA2 GGA3 GGA1

2.90e-075108322291915
Pubmed

Sorting of mannose 6-phosphate receptors mediated by the GGAs.

GGA2 GGA3 GGA1

2.90e-075108311387475
Pubmed

GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth.

GGA2 GGA3 GGA1

2.90e-075108329358589
Pubmed

GGA and Arf proteins modulate retrovirus assembly and release.

GGA2 GGA3 GGA1

2.90e-075108318439901
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

UNC13B ABCA2 WNT7B AKNA JADE1 CDC42BPB REXO1 GGA3 JUND FASN LLGL2 SHANK2 KLHL36 INTS11 GGA1 AP3D1

3.18e-0711051081635748872
Pubmed

Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin.

GGA2 GGA3 GGA1

5.78e-076108310814529
Pubmed

Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability.

GGA2 GGA3 GGA1

5.78e-076108316996030
Pubmed

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.

GGA2 GGA3 GGA1

5.78e-076108312215646
Pubmed

Interactions of GGA3 with the ubiquitin sorting machinery.

GGA2 GGA3 GGA1

5.78e-076108315039775
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

MID2 CAMP SHMT1 IDH1 CDC42BPB BGN ARPC2 S100A8 PALS1 MELTF FASN EYS UGP2 ALB CCDC180

6.05e-0710161081519056867
Pubmed

Molecular genetics of successful smoking cessation: convergent genome-wide association study results.

TDRD5 CACNB2 DAPK1 ADCY2 UNC13C CACNA2D3

7.77e-07101108618519826
Pubmed

Human immunodeficiency virus type-1 gag and host vesicular trafficking pathways.

GGA2 GGA3 GGA1 AP3D1

8.91e-0724108420012524
Pubmed

Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes.

GGA2 GGA3 GGA1

1.01e-067108315047686
Pubmed

Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains.

GGA2 GGA3 GGA1

1.01e-067108311390366
Pubmed

GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.

GGA2 GGA3 GGA1

1.01e-067108311950392
Pubmed

Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex.

GGA2 GGA3 GGA1

1.01e-067108312505986
Pubmed

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

UNC13B SYT1 RIMBP2 UNC13C

1.25e-0626108417124501
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MYH11 NLRP7 SPTA1 RDH12 APOB ZNF318 ARPC2 PDIA4 FASN SHANK2 RDH11 SACS UGP2 IFT122 MLPH AP3D1 TOP2B

2.23e-0614421081735575683
Pubmed

Definition of the consensus motif recognized by gamma-adaptin ear domains.

GGA2 GGA3 GGA1

2.41e-069108314665628
Pubmed

Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse.

SPTA1 DAPK1 APOB PRIM1 ALB

4.08e-067610858288233
Pubmed

Molecular and functional architecture of striatal dopamine release sites.

UNC13B RIMBP2 UNC13C

4.72e-0611108334767769
Pubmed

A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.

GGA2 GGA3 GGA1

4.72e-0611108310747088
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

MYH11 CAMP SHMT1 APOB IDH1 BGN ARPC2 S100A8 PALS1 MELTF FASN UGP2 ALB MLPH

5.95e-0610701081423533145
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

GPD2 CACNB2 ABCA2 MYH11 SPTA1 DAPK1 IDH1 ARPC2 PDIA4 FASN LLGL2 AP3D1

8.18e-068071081230575818
Pubmed

Peptide selectivity discriminates NK cells from KIR2DL2- and KIR2DL3-positive individuals.

KIR2DL2 KIR2DL3

9.55e-062108225359276
Pubmed

Allelic polymorphism of KIR2DL2/2DL3 in a southern Chinese population.

KIR2DL2 KIR2DL3

9.55e-062108226423800
Pubmed

The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.

PRKX PRKY

9.55e-06210827633447
Pubmed

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C.

KIR2DL2 KIR2DL3

9.55e-062108233846289
Pubmed

Do GGA adaptors bind internal DXXLL motifs?

GGA2 GGA1

9.55e-062108222762444
Pubmed

A deletional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin Tokyo (beta 220/216).

SPTA1 SPTB

9.55e-06210821391962
Pubmed

Identification of four novel KIR2DL2 alleles and two novel KIR2DL3 alleles in an East African population.

KIR2DL2 KIR2DL3

9.55e-062108220875478
Pubmed

Chaperone activity and prodan binding at the self-associating domain of erythroid spectrin.

SPTA1 SPTB

9.55e-062108215492010
Pubmed

Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1.

SPTA1 SPTB

9.55e-06210828102379
Pubmed

Man to mouse--lessons learned from the distal end of the human X chromosome.

PRKX PRKY

9.55e-06210829414316
Pubmed

Beta-spectrin Promiss-ao: a translation initiation codon mutation of the beta-spectrin gene (ATG --> GTG) associated with hereditary spherocytosis and spectrin deficiency in a Brazilian family.

SPTA1 SPTB

9.55e-06210829414314
Pubmed

Profiles of PrKX expression in developmental mouse embryo and human tissues.

PRKX PRKY

9.55e-062108215879576
Pubmed

Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.

SPTA1 SPTB

9.55e-06210829005995
Pubmed

Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis.

SPTA1 SPTB

9.55e-06210827104494
Pubmed

Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth.

RB1 JUND

9.55e-062108212894219
Pubmed

A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis.

SPTA1 SPTB

9.55e-06210826215583
Pubmed

Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals.

KIR2DL2 KIR2DL3

9.55e-062108215248031
Pubmed

Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.

KIR2DL2 KIR2DL3

9.55e-062108223686481
Pubmed

Usefulness of immunohistochemical expression analysis of metabolic-related molecules in differentiating between intracranial neoplastic and non-neoplastic lesions.

IDH1 FASN

9.55e-062108223064941
Pubmed

Spectrin Nice (beta 220/216): a shortened beta-chain variant associated with an increase of the alpha I/74 fragment in a case of elliptocytosis.

SPTA1 SPTB

9.55e-06210823580577
Pubmed

Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.

SPTA1 SPTB

9.55e-06210827883966
Pubmed

Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.

RDH12 RDH11

9.55e-062108219686838
Pubmed

Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses.

UNC13B UNC13C

9.55e-062108222674279
Pubmed

Spectrin Cosenza: a novel beta chain variant associated with Sp alphaI/74 hereditary elliptocytosis.

SPTA1 SPTB

9.55e-06210829163587
Pubmed

No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's disease.

ABCA2 DAPK1

9.55e-062108218336955
Pubmed

Identification of three novel spectrin alpha I/74 mutations in hereditary elliptocytosis: further support for a triple-stranded folding unit model of the spectrin heterodimer contact site.

SPTA1 SPTB

9.55e-06210828018926
Pubmed

PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.

PRKX PRKY

9.55e-062108221684272
Pubmed

Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.

PRKX PRKY

9.55e-06210829302280
Pubmed

Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function.

RDH12 RPE65

9.55e-062108217130236
Pubmed

KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles.

KIR2DL2 KIR2DL3

9.55e-062108227030405
Pubmed

Erythrocyte spectrin is comprised of many homologous triple helical segments.

SPTA1 SPTB

9.55e-06210826472478
Pubmed

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses.

UNC13B RIMBP2

9.55e-062108231535974
Pubmed

Identification of the proteoglycan binding site in apolipoprotein B48.

APOB BGN

9.55e-062108212070165
Pubmed

An insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216).

SPTA1 SPTB

9.55e-06210822070088
Pubmed

Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis.

SPTA1 SPTB

9.55e-06210829373273
Pubmed

Novel mutations in SPTA1 and SPTB identified by whole exome sequencing in eight Thai families with hereditary pyropoikilocytosis presenting with severe fetal and neonatal anaemia.

SPTA1 SPTB

9.55e-062108230198572
Pubmed

Spectrin mutations in hereditary elliptocytosis and hereditary spherocytosis.

SPTA1 SPTB

9.55e-06210828844207
Pubmed

Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation.

SPTA1 SPTB

9.55e-06210822056132
Pubmed

Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis.

SPTA1 SPTB

9.55e-06210822346784
Pubmed

GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network.

GGA2 GGA3

9.55e-062108215039776
Pubmed

RDH12 and RPE65, visual cycle genes causing leber congenital amaurosis, differ in disease expression.

RDH12 RPE65

9.55e-062108217197551
Pubmed

Exome sequencing: an efficient diagnostic tool for complex neurodegenerative disorders.

APOB SACS

9.55e-062108223043354
Pubmed

Differential association of gene content polymorphisms of killer cell immunoglobulin-like receptors with placental malaria in HIV- and HIV+ mothers.

KIR2DL2 KIR2DL3

9.55e-062108222715396
Pubmed

Spectrin cagliari. an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer.

SPTA1 SPTB

9.55e-06210828226774
Pubmed

Properties of human red cell spectrin heterodimer (side-to-side) assembly and identification of an essential nucleation site.

SPTA1 SPTB

9.55e-06210821634521
Pubmed

Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis.

SPTA1 SPTB

9.55e-062108222164239
Pubmed

A novel murine PKA-related protein kinase involved in neuronal differentiation.

PRKX PRKY

9.55e-062108210729225
Pubmed

Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex.

SPTA1 SPTB

9.55e-062108220197550
Pubmed

A structural model of the erythrocyte spectrin heterodimer initiation site determined using homology modeling and chemical cross-linking.

SPTA1 SPTB

9.55e-062108217977835
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTA1 SPTB SPTBN5

2.30e-0518108312119179
Pubmed

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

AKNA SHMT1 IDH1 PDIA4 S100A8 FASN ALB CCDC180

2.67e-05382108837249651
Pubmed

The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.

GGA2 GGA1

2.86e-053108217596511
Pubmed

Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.

KIR2DL2 KIR2DL3

2.86e-053108230696053
Pubmed

Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12.

RDH12 RPE65

2.86e-053108222621924
Pubmed

The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding.

SPTA1 SPTB

2.86e-053108220585040
GeneFamilyGolgi associated, gamma adaptin ear containing, ARF binding proteins

GGA2 GGA3 GGA1

6.86e-0837531031
GeneFamilyEF-hand domain containing|Spectrins

SPTA1 SPTB SPTBN5

2.37e-0677531113
GeneFamilyUNC13 homologs

UNC13B UNC13C

1.01e-044752836
GeneFamilyShort chain dehydrogenase/reductase superfamily

UXS1 RDH12 FASN RDH11

2.80e-0476754743
GeneFamilyEF-hand domain containing

GPD2 LPCAT1 SPTA1 CAPN3 EFHB S100A8

2.96e-04219756863
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR2DL2 KIR2DL3

2.49e-0318752620
GeneFamilyNLR family

NLRP7 NLRP10

4.79e-0325752666
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP7 NLRP10

4.79e-0325752994
GeneFamilyCalcium voltage-gated channel subunits

CACNB2 CACNA2D3

5.17e-0326752253
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

CACNB2 PALS1

5.17e-0326752904
CoexpressionGSE6269_HEALTHY_VS_E_COLI_INF_PBMC_UP

GGA2 CAPN3 JADE1 NSUN5 LLGL2 ZNF45 INTS11 ABCD4

7.31e-071771088M5641
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#2_top-relative-expression-ranked_1000

TDRD5 ZNF318 JADE1 DDX10 PALS1

1.75e-05651055gudmap_developingGonad_e12.5_epididymis_k2_1000
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DAPK1 GPC6 PLEKHG4B LLGL2 SHANK2 SCNN1G CACNA2D3

2.58e-0717710879af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DAPK1 GPC6 PLEKHG4B LLGL2 SHANK2 SCNN1G CACNA2D3

3.01e-071811087b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DAPK1 GPC6 PLEKHG4B LLGL2 SHANK2 SCNN1G CACNA2D3

3.36e-07184108742ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DAPK1 GPC6 PLEKHG4B LLGL2 SHANK2 SCNN1G CACNA2D3

3.61e-0718610874e94158db52df41d71e67b02b9895a358eebee0f
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DAPK1 GPC6 PLEKHG4B LLGL2 SHANK2 SCNN1G CACNA2D3

3.61e-0718610873aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LPCAT1 DAPK1 GPC6 PLEKHG4B LLGL2 SHANK2 CACNA2D3

3.75e-07187108758d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellAdult|World / Lineage, Cell type, age group and donor

LPCAT1 FASN LLGL2 KCNMA1 GGA1 MLPH CACNA2D3

4.03e-0718910875cd285bfad973125d46d704fec18b21266a63379
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNB2 MYH11 ADCY2 SACS KCNMA1 PLXNB3 CACNA2D3

5.14e-0719610879830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCellLPS_only-Epithelial_airway-airway_epithelial|LPS_only / Treatment groups by lineage, cell group, cell type

TDRD5 WNT7B ZBBX CERS3 ALB CCDC180 TMEM40

5.51e-071981087e035380578c01b0243bfef29ca9b50cc17cce771
ToppCellLPS_only-Epithelial_airway|LPS_only / Treatment groups by lineage, cell group, cell type

TDRD5 WNT7B ZBBX CERS3 ALB CCDC180 TMEM40

5.51e-071981087ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

WNT7B EFHB ADCY2 ZBBX ALB CCDC180 TMEM40

5.89e-072001087da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

WNT7B EFHB ADCY2 ZBBX ALB CCDC180 TMEM40

5.89e-07200108772c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Club_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

WNT7B ADCY2 ZBBX SCNN1G ALB TMEM40

3.58e-0616910868c96e1baa38ec5e777e627ab9dbce025e771f2c0
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Club_cells-Airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

WNT7B ADCY2 ZBBX SCNN1G ALB TMEM40

3.58e-06169108686041be5d3aeab5b9269f7912791b944f325a1b4
ToppCellHealthy-Plasmablast|World / disease group, cell group and cell class

SHMT1 ZBBX PDIA4 KCNMA1 UNC13C ALB

4.24e-0617410866becb456d8f44a1224c6d42be78d4c8cdb51f199
ToppCellNS-moderate-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CACNB2 SPTB GPC6 KCNMA1 SCNN1G RIMBP2

4.38e-061751086a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCellControl-Epithelial_alveolar-AT_1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DAPK1 GPC6 PLEKHG4B LLGL2 SHANK2 CACNA2D3

4.83e-061781086aa7d43c655df493f1330a5001efaa484e4a19f69
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GPC6 PLEKHG4B LLGL2 SHANK2 SCNN1G CACNA2D3

4.99e-06179108604ce3673e46606f63d9c87bcba3a64c96817d812
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GPC6 PLEKHG4B LLGL2 SHANK2 SCNN1G CACNA2D3

6.02e-061851086c82eab551f65ecebe6db908eda9f9eb3414693c7
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 MYH11 GPC6 KCNMA1 SYT1 DIXDC1

6.21e-0618610866add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

UNC13B LPCAT1 FASN LLGL2 SHANK2 MLPH

6.60e-061881086c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellfacs-Skin-Anagen|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GGA2 IDH1 GPC6 BGN PDIA4 ALB

6.81e-061891086adbfc723130079b4caf551f66d2aee86fab1903c
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B WNT7B PLEKHG4B LLGL2 SHANK2 RIMBP2

7.01e-061901086625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 MYH11 GPC6 ADCY2 KCNMA1 FERMT2

7.01e-061901086562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCellfacs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 ADCY2 KCNMA1 SYT1 DIXDC1 CACNA2D3

7.01e-061901086c7bd087f36321cec61b98657433b4d19d135791f
ToppCellfacs-Skin-Anagen-3m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GGA2 IDH1 GPC6 BGN PDIA4 ALB

7.01e-061901086888ded899f0513d41bf655896d59ae8ef74e0978
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 MYH11 GPC6 ADCY2 KCNMA1 FERMT2

7.01e-061901086f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCellfacs-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 ADCY2 KCNMA1 SYT1 DIXDC1 CACNA2D3

7.01e-061901086834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCellfacs-Skin-Anagen-3m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GGA2 IDH1 GPC6 BGN PDIA4 ALB

7.01e-0619010863466cebab16964e94da130d0673fa32e7d90b5ed
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

WNT7B ADCY2 PLEKHG4B SHANK2 SCNN1G MLPH

7.01e-06190108651ca9ef4df3220487152fcf684147730637c7cc1
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH11 ADCY2 BGN KCNMA1 SYT1 CACNA2D3

7.23e-061911086fd8331c7abdd999f55ba43d307945c6abfccbf84
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B LPCAT1 DAPK1 LLGL2 SHANK2 MLPH

7.23e-061911086ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B LPCAT1 DAPK1 LLGL2 SHANK2 MLPH

7.45e-06192108629f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|390C / Donor, Lineage, Cell class and subclass (all cells)

WNT7B ZFYVE1 IFIT2 CDC42BPB UBE2Q2

7.60e-061111085dfbdeadad321392d359e6fb7112b28b043a4b874
ToppCell3'_v3-bone_marrow-Lymphocytic_NK|bone_marrow / Manually curated celltypes from each tissue

LPCAT1 AKNA ARPC2 LLGL2 KIR2DL3 PRKX

7.67e-061931086e790ab76c12f74a13936c231076f1e397283efb3
ToppCell3'_v3-bone_marrow-Lymphocytic_NK-NK_CD16|bone_marrow / Manually curated celltypes from each tissue

LPCAT1 AKNA ARPC2 LLGL2 KIR2DL3 PRKX

7.90e-0619410867773501e076d470158dbc1d7f10c67152b326eb7
ToppCell10x5'-blood-Lymphocytic_NK|blood / Manually curated celltypes from each tissue

LPCAT1 AKNA JUND LLGL2 KIR2DL3 PRKX

8.14e-061951086c1db871e8e8e8b8d6a5798bc43eaf54e102b75eb
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH11 ADCY2 BGN KCNMA1 SYT1 CACNA2D3

8.14e-061951086c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH11 ADCY2 BGN KCNMA1 SYT1 CACNA2D3

8.14e-061951086ea89f80d3d7e9f737442f7c1aa1791d277ffc90c
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LPCAT1 DAPK1 GPC6 LLGL2 SHANK2 MLPH

8.62e-0619710863d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B LPCAT1 DAPK1 LLGL2 SHANK2 MLPH

9.13e-061991086725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B LPCAT1 DAPK1 LLGL2 SHANK2 MLPH

9.13e-0619910868587bd98de7767a575088afbea07a1feb4516b9b
ToppCellCOVID_non-vent-Lymphocytic-ILC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

LPCAT1 ABCA2 AKNA LLGL2 KIR2DL2 KIR2DL3

9.13e-061991086df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B LPCAT1 DAPK1 LLGL2 SHANK2 MLPH

9.13e-0619910865cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCellCOVID_non-vent-Lymphocytic-ILC-NK_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

LPCAT1 ABCA2 AKNA LLGL2 KIR2DL2 KIR2DL3

9.13e-061991086ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

WNT7B ADCY2 ZBBX ALB CCDC180 TMEM40

9.13e-06199108660919c2af31d39a2d36d7bc432e43dab2a4e05fb
ToppCellControl_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets|Control_saline / Treatment groups by lineage, cell group, cell type

GPD2 PANK3 RDH12 NARF SHANK2 TMEM40

9.13e-06199108686d4e5dd3bcc6bafa48fd0211dad39a2456b53be
ToppCellLPS_anti-TNF-Epithelial_airway|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

WNT7B ADCY2 ZBBX ALB CCDC180 TMEM40

9.13e-0619910866aca164bbbb961f34b1e6f1857f91ade5c059405
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

CACNB2 MYH11 BGN KCNMA1 SYT1 DIXDC1

9.40e-062001086c5e051f1aac8dda376c342a9932785a23450e073
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ADCY2 ZBBX CERS3 ALB CCDC180 TMEM40

9.40e-062001086cf191104484bfb2b9f87de416b9453135f8833c1
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / Treatment groups by lineage, cell group, cell type

LPCAT1 DAPK1 LLGL2 SHANK2 SCNN1G CACNA2D3

9.40e-0620010862dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DPY19L3 PLEKHG4B LLGL2 SHANK2 KCNMA1 MLPH

9.40e-062001086c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

CACNB2 MYH11 BGN KCNMA1 SYT1 DIXDC1

9.40e-0620010869d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CACNB2 MYH11 BGN KCNMA1 SYT1 DIXDC1

9.40e-06200108687827041663013f5e7273168dc8709d69840e7ce
ToppCellLPS_IL1RA-Epithelial_airway|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ADCY2 ZBBX CERS3 ALB CCDC180 TMEM40

9.40e-062001086a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LPCAT1 DAPK1 LLGL2 SHANK2 SCNN1G CACNA2D3

9.40e-0620010868683445ad5b70748c4a1f12eb77d47623085147e
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CACNB2 MYH11 BGN KCNMA1 SYT1 DIXDC1

9.40e-0620010868988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCellLPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SPTA1 SPTB RDH12 NARF MACO1 TMEM40

9.40e-062001086f99e214eb680fd82a33f2b1524fbfca265d1cc42
ToppCellLPS_IL1RA-Hematopoietic_Erythro-Megakary|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SPTA1 SPTB RDH12 NARF MACO1 TMEM40

9.40e-062001086d85074b362b11e5a523a5325d203a61aa2759a7a
ToppCellLPS_only-Epithelial_alveolar-AT_1|LPS_only / Treatment groups by lineage, cell group, cell type

LPCAT1 STAP2 DAPK1 LLGL2 SCNN1G CACNA2D3

9.40e-0620010869a6ae40f3e17cd44ee5fd73260713b920aa2ea15
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DPY19L3 DAPK1 LLGL2 SHANK2 KCNMA1 MLPH

9.40e-0620010860eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCellfacs-Liver-Non-hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 SPTB APOB ALB TMEM40

3.05e-0514810855c853637f6058f78608ba0e76cda72a548d40710
ToppCellfacs-Liver-Non-hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 SPTB APOB ALB TMEM40

3.05e-051481085763c598826445bf627989220cd7acd71c4f1ea36
ToppCellfacs-Liver-Non-hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 SPTB APOB ALB TMEM40

3.05e-051481085d3f224128593251b72429a1cd52e82f77df8e386
ToppCelldroplet-Heart-nan-18m-Myeloid|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMP RDH12 S100A8 CCDC180 TMEM40

4.17e-05158108581a5a73090804d41429d297ba2462a842f39d380
ToppCelldroplet-Heart-nan-18m-Myeloid-cardiac_mast_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMP RDH12 S100A8 CCDC180 TMEM40

4.17e-0515810859596b7b0f6f5157a43d67d2e67fb75a2624a6bb9
ToppCelldroplet-Heart-nan-18m-Myeloid-mast_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMP RDH12 S100A8 CCDC180 TMEM40

4.17e-0515810857ebc8b778c97c0faa79e2d80c98b887fa635f901
ToppCellControl-Epithelial_airway|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

WNT7B ADCY2 ZBBX ALB TMEM40

4.17e-05158108535aee1c3b92169e73569331022833cb44ab7e7e8
ToppCelldroplet-Lung-1m-Hematologic-myeloid-neutrophil-neutrophil|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CAMP RDH12 S100A8 CCDC180 TMEM40

4.30e-051591085be54b910ccb73e37eb81945bbad9a89d2bcec34b
ToppCelldroplet-Lung-1m-Hematologic-myeloid-neutrophil|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CAMP RDH12 S100A8 CCDC180 TMEM40

4.30e-051591085178678173b005cb8225472306657f0d8289b133b
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 ADCY2 KCNMA1 RIMBP2 CACNA2D3

4.43e-051601085c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 ADCY2 KCNMA1 RIMBP2 CACNA2D3

4.43e-05160108525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GPC6 LLGL2 SHANK2 SCNN1G CACNA2D3

4.57e-0516110851e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCelldroplet-Lung-21m-Hematologic-myeloid-neutrophil|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CAMP RDH12 S100A8 CCDC180 TMEM40

4.70e-051621085f24eb596653180040bfdefad9c246fc42cbfaac8
ToppCelldroplet-Lung-21m-Hematologic-myeloid-neutrophil-neutrophil|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CAMP RDH12 S100A8 CCDC180 TMEM40

4.70e-0516210851a953e165b7e469815294728350ec13d27c9bd9d
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD5 CAMP S100A8 MLPH CACNA2D3

4.84e-05163108557f02f2b9ce940a2962bb57cd8d02eb67b6f44a3
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD5 CAMP S100A8 MLPH CACNA2D3

4.84e-051631085155ac52a34e0d55545aab8a3e4162fc4c387e697
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD5 CAMP S100A8 MLPH CACNA2D3

4.84e-051631085c132fb5b56186a10d33ae5ce17b2a7e670d52f79
ToppCellLPS-antiTNF-Epithelial_airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADCY2 ZBBX SCNN1G ALB CCDC180

5.28e-051661085eb942ed68677e55c46cb039046f45686d4062d7c
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMP RDH12 ARPC2 S100A8 TMEM40

5.28e-051661085a1211afc1197d078eb3db0d0f788ecaf4419aa5b
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|343B / Donor, Lineage, Cell class and subclass (all cells)

CAMP CHEK1 DMC1 ZNF45 KCNMA1

5.43e-0516710857efa0081e79f22b219eac64ffcaedb2179cde299
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

CACNB2 MYH11 SPTB GPC6 CERS3

5.43e-051671085c4e321bb87512ea839f324c92c0f1afea891483f
ToppCellControl|World / group, cell type (main and fine annotations)

UNC13B SHANK2 SYT1 MLPH CACNA2D3

5.59e-051681085a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellnormal_Lung-Fibroblasts-Pericytes|Fibroblasts / Location, Cell class and cell subclass

UXS1 MYH11 BGN SCNN1G PRKX

5.91e-051701085d69c0ea4cb6b204f19d0a5d2164afb42184779ac
ToppCelldroplet-Spleen-nan-3m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMP STAP2 S100A8 DMC1 TMEM40

5.91e-051701085dbd6c9c7be824a1ff1b31af791064127cafbd194
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNB2 MYH11 SACS KCNMA1 CACNA2D3

6.42e-051731085cb6389536195443633adb06e5f1b7483530773d1
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYH11 ADCY2 FERMT2 RPE65 PLXNB3

6.42e-051731085f8e3dded726bb3a6c24bfedf8c6732bb46262308
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMP AKNA CHEK1 S100A8 CCDC180

6.60e-051741085723848d2f8ae9cf4f15d4b4a130f9a64dab443c7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 MYH11 GPC6 KCNMA1 RPE65

6.78e-051751085d52794426f2703a80e91ae0a8ff2d8e0ce4aa4a8
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNB2 ZBBX EYS SYT1 RIMBP2

6.78e-051751085182e45f5c02214d6b9f317ff5dc43af8b42de978
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 MYH11 GPC6 KCNMA1 RPE65

6.78e-051751085454f03e6109d65f5db08dbb41ecc19ffb6bbc4e0
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

ARPC2 S100A8 CERS3 PRKY TMEM40

6.96e-0517610858513c2a05a34453a16bbcf1c11cb34c580133e47
ToppCellLPS-IL1RA+antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 IDH1 GPC6 SHANK2 CACNA2D3

7.15e-051771085b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYH11 ADCY2 FERMT2 RPE65 PLXNB3

7.15e-051771085e65c0568dc5852108e9802273499bc7cf88fafab
ToppCellnormal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ|normal_Lymph_Node / Location, Cell class and cell subclass

GGA2 CAMP ARPC2 SHANK2 KCNMA1

7.35e-051781085d75057e7463558a0d3cebde3c30befbf4704dd9a
ToppCellwk_15-18-Hematologic-Meg-ery-Definitive_erythroblast|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SPTA1 SPTB ZFYVE1 NARF MACO1

8.16e-05182108593841f730ca1a735eaaf5f2ccbe5c45ab0e029d1
ToppCellfacs-Tongue-nan-24m-Epithelial-keratinocyte|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAP2 RDH12 SERPINB12 CERS3 TMEM40

8.16e-05182108541f1749e2368397bca49143786da0423792f03bd
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-AT1-AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STAP2 GPC6 LLGL2 SHANK2 CACNA2D3

8.16e-051821085cc79e0cc21e2fdc4ef77f052818d27b9f707aec1
ToppCellNS-critical-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GPC6 KCNMA1 SCNN1G RIMBP2 UNC13C

8.37e-051831085ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCellCOVID-19-Epithelial_cells-ECM-high_epithelial|COVID-19 / group, cell type (main and fine annotations)

UNC13B LPCAT1 GPC6 SHANK2 MLPH

8.37e-051831085dc1d380bf7564f290256cb7108063d1bd2da732b
DrugSulpiride [15676-16-1]; Up 200; 11.8uM; HL60; HG-U133A

GGA2 MID2 CAPN3 CHEK1 BGN OSGEPL1 DIXDC1 IFT122 AP3D1

4.05e-0719610891967_UP
Drugprodan

SPTA1 SPTB ALB

4.14e-0741083ctd:C038517
Drugverapamil

CACNB2 ABCA2 MYH11 APOB ADCY2 ABCD4 KCNMA1 SCNN1G DIXDC1 ALB TOP2B CACNA2D3

3.71e-0649010812CID000002520
DrugTalampicillin hydrochloride [39878-70-1]; Up 200; 7.8uM; HL60; HT_HG-U133A

ABCA2 GIT1 SPTB PAPOLG SPTBN5 DMC1 SHANK2 GGA1

4.58e-0619710882954_UP
DrugGuanidine

SPTA1 SPTB ALB

5.71e-0681083ctd:D019791
Drugethanol

GPD2 CACNB2 SPTA1 SPTB APOB ADCY2 DDX10 PDIA4 SPTBN5 JUND KCNMA1 SCNN1G SYT1 ALB GPSM1

9.69e-0683710815CID000000702
DiseaseLeber congenital amaurosis (implicated_via_orthology)

RDH12 PALS1 RDH11

1.22e-05131053DOID:14791 (implicated_via_orthology)
Diseaselysosomal storage disease (implicated_via_orthology)

GGA2 GGA3 GGA1

2.37e-05161053DOID:3211 (implicated_via_orthology)
Diseasesevere acute respiratory syndrome, COVID-19

ATP8B3 ZFYVE1 REXO1 ARPC2 EYS KCNMA1 RIMBP2 UNC13C CACNA2D3

3.23e-054471059EFO_0000694, MONDO_0100096
DiseaseHereditary elliptocytosis

SPTA1 SPTB

7.49e-0541052cv:C0013902
Diseasehereditary spherocytosis (is_implicated_in)

SPTA1 SPTB

1.25e-0451052DOID:12971 (is_implicated_in)
DiseaseHereditary spherocytosis

SPTA1 SPTB

1.25e-0451052cv:C0037889
DiseaseAnemia, hereditary spherocytic hemolytic

SPTA1 SPTB

1.25e-0451052C0221409
Diseaseneurodegenerative disease (implicated_via_orthology)

GGA2 SLC1A6 GGA3 SCNN1G GGA1

1.74e-041451055DOID:1289 (implicated_via_orthology)
DiseaseRespiratory Tract Diseases

DAPK1 ALB

1.86e-0461052C0035242
DiseaseElliptocytosis, Hereditary

SPTA1 SPTB

1.86e-0461052C0013902
Diseaseobsolete_red blood cell distribution width

DPY19L3 IRF2BP1 SPTA1 SPTB SHMT1 ARMH1 APOB ZFYVE1 F8 REXO1 ARPC2 PRIM1 GPSM1 TMEM40

3.01e-04134710514EFO_0005192
DiseaseHereditary spherocytosis

SPTA1 SPTB

3.46e-0481052C0037889
DiseaseRetinal Dystrophies

RDH12 RPE65

3.46e-0481052C0854723
Diseasecancer (implicated_via_orthology)

RB1 IDH1 LLGL2 UGP2 GPSM1 TOP2B

4.03e-042681056DOID:162 (implicated_via_orthology)
Diseasepyoderma gangrenosum

ARPC2 SERPINB12

4.44e-0491052EFO_0006835
Diseasemetabolic rate measurement

CACNB2 ARPC2

6.76e-04111052EFO_0005115
Diseaseinflammatory biomarker measurement, YKL40 measurement

CACNB2 MYH11 ZNF45

8.05e-04511053EFO_0004869, EFO_0004872
DiseaseAcute Myeloid Leukemia, M1

MYH11 DAPK1 IDH1 S100A8

1.05e-031251054C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

MYH11 DAPK1 IDH1 S100A8

1.05e-031251054C1879321
DiseaseLeber congenital amaurosis

RDH12 RPE65

1.46e-03161052cv:C0339527
DiseaseMalignant neoplasm of breast

RB1 MCF2L2 SHMT1 ZNF318 CHEK1 BGN GGA3 DDX10 FASN LLGL2 GGA1

1.55e-03107410511C0006142
DiseaseManic Disorder

ADCY2 SHANK2 DIXDC1

2.10e-03711053C0024713
DiseaseRetinitis pigmentosa

RDH12 EYS RPE65

2.36e-03741053cv:C0035334
DiseaseRetinal Degeneration

RDH12 RPE65

2.52e-03211052C0035304
DiseaseManic

ADCY2 SHANK2 DIXDC1

2.74e-03781053C0338831
DiseaseLeber Congenital Amaurosis

RDH12 RPE65

2.77e-03221052C0339527
Diseaseproprotein convertase subtilisin/kexin type 9 measurement

APOB DDX10

2.77e-03221052EFO_0009312
Diseaseepilepsy (implicated_via_orthology)

UNC13B SLC1A6 KCNMA1 UNC13C

2.78e-031631054DOID:1826 (implicated_via_orthology)
DiseaseDepression, Bipolar

ADCY2 SHANK2 DIXDC1

2.85e-03791053C0005587
DiseaseCoronary heart disease

APOB MACO1

3.29e-03241052C0010068
Diseaseglioblastoma (is_implicated_in)

RB1 IDH1

3.29e-03241052DOID:3068 (is_implicated_in)
DiseaseDyslipidemias

APOB MACO1

3.29e-03241052C0242339
DiseaseDyslipoproteinemias

APOB MACO1

3.29e-03241052C0598784
DiseaseLeukemia, Myelocytic, Acute

MYH11 DAPK1 IDH1 S100A8

3.44e-031731054C0023467
Diseasememory performance

UNC13B MYH11 GPC6 PLEKHG4B EYS UNC13C

3.48e-034091056EFO_0004874
Diseasesquamous cell lung carcinoma, family history of lung cancer

GPD2 SLC1A6 ZBBX

3.50e-03851053EFO_0000708, EFO_0006953

Protein segments in the cluster

PeptideGeneStartEntry
EEGLNKAIHYFRKEL

UXS1

381

Q8NBZ7
FRKGHQDLLVFDADK

TDRD5

356

Q8NAT2
DFGLAHKIDFGNEFK

DAPK1

161

P53355
VAHRFKDLGEENFKA

ALB

31

P02768
FRLSKGDGLEFKRHF

CHEK1

441

O14757
DNAGKVARSHILDKF

ARMH1

21

Q6PIY5
LKFYKELQAHGADEL

ARPC2

61

O15144
TLKDFKAAIDREGNH

DIXDC1

626

Q155Q3
EGKRFLELGKEEDFH

GIT1

611

Q9Y2X7
KFADGKLLFHNAALL

ATP8B3

536

O60423
DEHIFKFLKAKFGLG

DPY19L3

371

Q6ZPD9
KLVHQEKLEGDFRFK

ABCD4

211

O14678
ILEIKKQLRAGFFEH

CCDC180

871

Q9P1Z9
VAAKFHEEAGIFKLL

DMC1

206

Q14565
QKALFDFLKHRFEGR

CACNB2

301

Q08289
KNDEGATHEKLDFRL

AP3D1

1026

O14617
LKNKDLDARLFLDHD

RB1

326

P06400
QGKIFAFDLDAKRLA

NSUN5

251

Q96P11
RAFAEGFLAEEKQLH

RDH12

106

Q96NR8
EHLAKQGNRFHFDIK

OSGEPL1

226

Q9H4B0
EEKGKITFADFHRFA

LPCAT1

466

Q8NF37
EHFLLHREGKFKDTL

KIR2DL2

56

P43627
KRLDAFIDGFILNHF

KLHL36

161

Q8N4N3
RFHKFDADQKGFITI

GPD2

631

P43304
LFNEDFNKKHFRAGA

HSFY1

206

Q96LI6
DRFEEAQKAFHKAGR

IFT122

876

Q9HBG6
NKEFFIIDEARHGKN

EYS

2316

Q5T1H1
VSNFLKDFLHKDRDD

KCNMA1

421

Q12791
LKRDLFQFNKTVEHG

LLGL2

16

Q6P1M3
QVHGKKLFLRFDLDE

NEIL2

46

Q969S2
EFKHIKAFDRAFADN

INTS11

301

Q5TA45
QHFLLHREGKFKDTL

KIR2DL3

56

P43628
FLFEEAELRKHNLDG

NLRP10

426

Q86W26
FHKERLAIAKEFGDK

GPSM1

231

Q86YR5
FAEGFVKALEDLHKQ

JUND

136

P17535
AAIRFKDLKNFHVDL

MACO1

136

Q8N5G2
DILGKSLEFHRQLDK

MCF2L2

421

Q86YR7
KYLFDLLDELAEKHG

PLXNB3

1726

Q9ULL4
DISELRKDDFKGLQH

BGN

101

P21810
FHDEVGKFRFLNELI

GGA1

81

Q9UJY5
KFHSEVAKFRFLNEL

GGA2

96

Q9UJY4
HNEVGKFRFLNELIK

GGA3

81

Q9NZ52
LHKFILLFAVFDEGK

F8

211

P00451
NGIEDFKKHAFFEGL

CDC42BPB

331

Q9Y5S2
FEKDFRTIGNLHLHK

PANK3

121

Q9H999
AAGKFIEHGEFEKNL

PALS1

541

Q8N3R9
IIDRALKEDFGFKHR

PRIM1

141

P49642
EHFLENLDKSRKGEL

PRIM1

396

P49642
SFFEKLKHQDGIRNL

PAPOLG

131

Q9BWT3
DFFKALGRVKQIHND

COG6

181

Q9Y2V7
FAFALVGKLDAINKH

ADCY2

976

Q08462
REHNAKFSLDGKAAL

APOB

1691

P04114
LGFDVKRKDFLAHII

CERS3

196

Q8IU89
AHRAKLDNNKELAFF

IDH1

341

O75874
RHKKFDEFFRELLEN

GPC6

101

Q9Y625
EFRAHVAKKLGALLD

CUSTOS

81

Q96C57
EHFREHLDKLFAKGI

CACNA2D3

321

Q8IZS8
FLKAGDKENIFNADH

CACNA2D3

751

Q8IZS8
EAAKKGAFERLFQHL

ABCA2

1281

Q9BZC7
KGFQRLKAAHAALEE

AKNA

596

Q7Z591
KHKGRVLRDFFDSLN

SLC1A6

286

P48664
DKDNKRFALLGDFFR

CAMP

126

P49913
AHLKKADEANDNLFR

IFIT2

321

P09913
DFKEKFQHKLGRVLD

EFHB

486

Q8N7U6
EDADFLKVKRHNVFG

DDX10

631

Q13206
FRSGQGKDLDFHKLE

CCDC168

1836

Q8NDH2
THFIARFQGGKKEEL

FERMT2

571

Q96AC1
KKDHRDNLEFFLAGI

FASN

786

P49327
FHAFDKDGDGIIKLN

CAPN3

796

P20807
LIFDQDEKGKARDFF

SCNN1G

161

P51170
DHLNEGKDSFRALKF

SACS

1261

Q9NZJ4
FKKDHGLVGRVFAFD

IRF2BP1

246

Q8IU81
KKRLLSVHDFDFEGD

MLPH

186

Q9BV36
RGLLEKDFQKVAHFI

SHMT1

411

P34896
DFDRFSKHDIIGEFK

SYT1

231

P21579
DHRKIGKEQELFFFH

TARS3

401

A2RTX5
LKKRALSHADLFGDE

REXO1

511

Q8N1G1
SIRAFAKGFLAEEKH

RDH11

106

Q8TC12
RDLEKFRQHAGKIDL

RIMBP2

56

O15034
FDGQALLHKFDFKEG

RPE65

61

Q16518
DFQHVEKLNLGAFEK

STAP2

56

Q9UGK3
KHLDGDNVKFILYED

SULT6B1

191

Q6IMI4
LIKGNFHAVYRDDLK

S100A8

21

P05109
EKLAQAEAAGLHKVF

TOP2B

996

Q02880
LLDKAQDLFGDDHNK

MELTF

641

P08582
DRDGHIKLTDFGFAK

PRKY

181

O43930
FLFGLANEKRAKELE

NLRP7

521

Q8WX94
KFEGGDRDLEHLSKF

PDIA4

616

P13667
DNRFHCDLIKGDLKD

JADE1

661

Q6IE81
FQEIGKDDRHKNIFF

SERPINB12

16

Q96P63
FQHKAALRESFLKDA

SPTBN5

431

Q9NRC6
ALKNGGAHLDFRAKD

SHANK2

216

Q9UPX8
LKRKLEGDASDFHEQ

MYH11

1056

P35749
FREVGHLLKEKYNAA

WNT7B

221

P56706
HEFEHTKKDLDGFRK

UGP2

46

Q16851
DGFRKLFHRFLQEKG

UGP2

56

Q16851
KFLASIFDKNHERFR

UBE2Q2

11

Q8WVN8
RVKQHFKKESDDFLG

UNC13C

1296

Q8NB66
HGNAFFKDKQRELGD

PLEKHG4B

911

Q96PX9
RLNIKKDDEFFHFVL

TMEM40

151

Q8WWA1
NLFRDFFLKHKIALD

ZBED8

221

Q8IZ13
LVDGFENKEFKIHLA

ZBED8

361

Q8IZ13
NFGKERFVKLLDQLH

UNC13B

851

O14795
QRKHKAFEDELRGLD

SPTB

676

P11277
EEAAGALLKKHEAFL

SPTA1

931

P02549
DRDGHIKLTDFGFAK

PRKX

181

P51817
DGKAHFLQLRKDFDQ

RIOX2

116

Q8IUF8
RLHNDLFKFLGDASE

ZFYVE1

271

Q9HBF4
GALHEDEARKKFHQL

TSSK1B

106

Q9BXA7
NFALDFSREKKLLEG

MID2

381

Q9UJV3
LREKFGSFLCHKDNL

ZNF318

466

Q5VUA4
QLEKRDDLHYKDEGF

ZNF45

131

Q02386
HVFDKGKRDFLNLCL

ZBBX

446

A8MT70
EKGEFHKLADAKIFL

NARF

36

Q9UHQ1